The present invention relates to modifications of berberine bridge enzyme-like nucleic acids and their use in modulation of nicotine biosynthesis in plants.
The present disclosure provides compositions and methods related to tobacco plants. In particular, the present disclosure provides novel methods for producing tobacco plants, and any related tobacco products, having low nicotinic alkaloid content. Tobacco plants produced according to the methods of the present disclosure exhibit reduced levels of nicotinic alkaloids (e.g., nicotine) compared to both naturally-occurring and transgenic tobacco plants, and thus represent a commercially valuable alternative to currently available tobacco varieties.
The present disclosure provides compositions and methods related to aptamers and aptamer-based sensors. In particular, the present disclosure provides methods to discover high-affinity aptamers with slow off-rate binding kinetics as well as aptamer-based sensors, and related detection assays, that are capable of detecting a target analyte (and derivatives and analogs thereof) at clinically relevant concentrations in biological fluids in a manner that is rapid, specific, and sensitive.
14 - Precious metals and their alloys; jewelry; time-keeping instruments
16 - Paper, cardboard and goods made from these materials
21 - HouseHold or kitchen utensils, containers and materials; glassware; porcelain; earthenware
36 - Financial, insurance and real estate services
41 - Education, entertainment, sporting and cultural services
Goods & Services
Shirts; Shorts; Pants; Clothing jackets; Sweatshirts; Sweatpants; Socks; Visors being headwear; Jerseys being clothing; Vests; Hats Pins being jewelry Decals; Stickers; Paper stationery Beverageware; Drinkware; Cups Fundraising services by means of organizing, arranging and conducting fundraising programs for the benefit of university
investments and scholarships Educating at universities or colleges; Education services in the nature of courses at the university level; Providing classroom instruction at the university level; Providing courses of instruction at the university level; Providing online courses of instruction at the university level; Arranging and conducting college athletic events; Arranging and conducting college athletic competitions; Organizing and conducting college sport competitions and athletic events
5.
AMPHIPHILIC POLYMERS WITH MULTIPLE CHROMOPHORES, COMPOSITIONS COMPRISING THE SAME, AND METHODS OF PREPARING AND USING THE SAME
Provided herein are compounds (e.g., polymers) that include a polymer backbone comprising one or more hydrophobic unit(s) and one or more hydrophilic unit(s) and one or more dye(s) and/or biomolecule(s) attached to a hydrophobic unit and/or hydrophilic unit. Compositions including such compounds, methods of making such compounds, and methods of using such compounds are also provided.
Disclosed herein is a novel Cas9 protein. Further described herein are fusion proteins, compositions, and methods comprising the same. The novel Cas9 protein may be used, for example, in compositions and methods for modulating expression of a gene, for correcting a mutant gene, and for treating a disease.
C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
C12N 15/11 - DNA or RNA fragmentsModified forms thereof
C12N 15/90 - Stable introduction of foreign DNA into chromosome
7.
Side-Channel Aware Training for Commercial Machine Learning Accelerators
Various examples are provided related to side-channel awareness. In one example, a method for side-channel awareness training includes generating trained models by stochastically training neural network models using a common training dataset; generating an inference model based upon random selection of parameters from one or more of the trained models; and training the inference model with the selected parameters. The trained inference model can be executed on an edge Tensor Processing Unit (TPU). The models can be trained offline. An input signal can be processed using the trained inference model to generate an output signal for transmission.
A system, method, and device for retaining an implanted medical device is disclosed, the device including: a sleeve body extending circumferentially around a first longitudinal axis. The sleeve body defines a first aperture on a first end of the sleeve body and a second aperture on a second end of the sleeve body. The second end is spaced apart longitudinally from the first end of the sleeve body. The device further includes a sheath coupled to an inner surface of the sleeve body and extending circumferentially around a second longitudinal axis. The sheath defines a third aperture on a first end of the sheath and a fourth aperture on a second end of the sheath. The second end of the sheath is spaced apart from the first end of the sheath.
The present technology provides methods of combining mutations in N-methylputrescine oxidase (MPO) gene isoforms with mutations in the three major berberine bridge enzyme-like (BBL) genes to produce low-nicotine tobacco plants and which prevent the accumulation of anatabine in the tobacco plants. Also provided are methods of combining these mutations to produce tobacco plants, tobacco cells, and tobacco products having reduced nicotine content and which avoid the unwanted consequence of elevated anatabine levels in the tobacco plants, cells, and products.
A system, method, and device for retaining an implanted medical device is disclosed, the device including: a sleeve body extending circumferentially around a first longitudinal axis. The sleeve body defines a first aperture on a first end of the sleeve body and a second aperture on a second end of the sleeve body. The second end is spaced apart longitudinally from the first end of the sleeve body. The device further includes a sheath coupled to an inner surface of the sleeve body and extending circumferentially around a second longitudinal axis. The sheath defines a third aperture on a first end of the sheath and a fourth aperture on a second end of the sheath. The second end of the sheath is spaced apart from the first end of the sheath.
A polymer solar cell ink for organic solar cell (OSC) devices is provided. The polymer solar cell ink includes at least one solid state additive. The polymer solar cell ink further includes a donor polymer. The polymer solar cell ink further includes a nonfullerene acceptor (NFA).
The present disclosure relates to a photoreactor and method of use thereof. In an aspect, the photoreactor can be configured as a solar panel comprising a channel containing a heterogeneous photocatalyst. When water or another hydrogen-containing liquid is pumped through the photoreactor, it contacts the photocatalyst in the presence of UV or visible irradiation, simultaneously releasing hydrogen and separating the hydrogen via a gas-permeable membrane. In an aspect, the photoreactor can be used in a method for continuous production of high-purity H2 gas, the method comprising dehydrogenating tetrahydroquinoline (THQ) to form quinoline under visible light using a Rh/TiO2 heterogeneous photocatalyst. In another aspect, the catalyst includes Rh particles photodeposited on TiO2 microparticles. In a further aspect, the method can include regenerating THQ from quinoline using a water gas shift (WGS) reaction.
B01J 19/12 - Processes employing the direct application of electric or wave energy, or particle radiationApparatus therefor employing electromagnetic waves
B01J 8/06 - Chemical or physical processes in general, conducted in the presence of fluids and solid particlesApparatus for such processes with stationary particles, e.g. in fixed beds in tube reactorsChemical or physical processes in general, conducted in the presence of fluids and solid particlesApparatus for such processes with stationary particles, e.g. in fixed beds the solid particles being arranged in tubes
B01J 19/24 - Stationary reactors without moving elements inside
C01B 3/26 - Production of hydrogen or of gaseous mixtures containing hydrogen by decomposition of gaseous or liquid organic compounds of hydrocarbons using catalysts
15.
COMPOSITIONS AND METHODS RELATED TO SOMATIC EMBRYOGENESIS IN ROSE PLANTS
The present disclosure provides compositions and methods for producing a rose plant using somatic embryogenesis. In particular, the present disclosure provides novel methods and media for rose callus induction, embryoid suspension, and embryo regeneration. Unlike currently available techniques, the novel compositions and methods provided herein produce high yields of competent cells and high frequencies of rose somatic embryogenesis.
The present disclosure provides compositions and methods related to the culturing of trophoblast stem cells (TSCs). In particular, the present disclosure provides novel formulations and methods for inducing and maintaining trophoblast stem cells obtained from cytotrophoblasts (CTBs) obtained from a placenta at birth. The compositions and methods described herein allow for the development of in vitro models of early human placental development and establish a platform for therapeutic discoveries.
The present disclosure provides materials and methods related to increasing viral resistance of plants. In particular, the present disclosure provides antiviral hairpin constructs having a stem region, wherein the stem region includes one or more polynucleotide sequences, wherein each of the one or more polynucleotide sequences individually have at least 70% identity or complementarity to a sequence from a target virus. Also provided are methods of increasing virus resistance or preventing viral infection in a plant comprising providing an antiviral hairpin construct or a nucleic acid encoding an antiviral hairpin construct to the plant.
‘NCCH3’ is a new cultivar of flowering dogwood with a unique combination of traits including large white bracts, large glossy leaves, a fast growth rate, and showy fall color.
The present disclosure provides compositions and methods related to opioid detection. In particular, the present disclosure provides aptamer-based colorimetric assays for the visualization and identification of specific opioids (natural, semi-synthetic, synthetic and the derivatives and analogs thereof) in a manner that is rapid, specific, and sensitive.
A wearable ultrasound device may include an array of ultrasound transducers, wherein each ultrasound transducer comprises: a matching layer on a top side, an active layer adjacent the matching layer, a first backing layer adjacent the active layer, a second backing layer adjacent the first backing layer; and an epoxy bonding material interspaced between each of the matching layer, the active layer, the first backing layer, and the second backing layer, wherein the array of ultrasound transducers is surrounded by a PDMS filling, whereby the active layer is configured to communicate a signal in response to mechanical deformation.
Various examples are provided related to ceramic substrate windings and their application. In one example, a ceramic substrate coil includes a ceramic substrate and at least one coil trace disposed on a first surface of the ceramic substrate, the at least one coil trace forming at least a partial loop about the ceramic substrate surface. In another example, a permanent magnet machine includes a rotor and a stator including ceramic coils. Each of the ceramic coils include a ceramic substrate and at least one coil trace disposed on a first surface of the ceramic substrate. The ceramic coils are positioned, and the coil traces are connected to form a stator winding of the permanent magnet machine.
H02K 3/26 - Windings characterised by the conductor shape, form or construction, e.g. with bar conductors consisting of printed conductors
H02K 1/12 - Stationary parts of the magnetic circuit
H02K 3/02 - Windings characterised by the conductor material
H02K 9/19 - Arrangements for cooling or ventilating for machines with closed casing and closed-circuit cooling using a liquid cooling medium, e.g. oil
H02K 9/22 - Arrangements for cooling or ventilating by solid heat conducting material embedded in, or arranged in contact with, the stator or rotor, e.g. heat bridges
22.
CLEAN LABEL ACCELERATED AGING PROCESS FOR DISTILLED SPIRITS
Disclosed herein is a method for accelerating aging of a beverage, the method comprising exposing the beverage to wood in a water bath at a temperature from 125°F-141°F for 14 to 28 days. Also disclosed is a kit for accelerating aging of a beverage, wherein the kit comprises wood designed for flavoring beverages and a kettle comprising a water bath. Further disclosed is an alcoholic beverage, wherein said beverage has been aged for less than 60 days, and wherein said beverage has a concentration of isoamyl alcohol of less than 200,000 µg/L, a concentration of ethyl decanoate of greater than 2,000 µg/L, and a concentration of syringol between 100 and 1,000 µg/L.
C12G 3/07 - Flavouring with wood extracts, e.g. generated by contact with woodWood pretreatment therefor
C12G 3/08 - Preparation of other alcoholic beverages by methods for altering the composition of fermented solutions or alcoholic beverages not provided for in groups
C12H 1/18 - Pasteurisation, sterilisation, preservation, purification, clarification, or ageing of alcoholic beverages without precipitation by physical means, e.g. irradiation by heating
23.
ATOMIC LAYER ETCHING OF METALS USING NOVEL CO-REACTANTS AS HALOGENATING AGENTS
The disclosed and claimed subject matter relates to thermal atomic layer etch (ALE) processing of metals and alloys thereof (e.g., cobalt and cobalt alloys) using thionyl chloride (SOCl2) or a combination of thionyl chloride and pyridine.
The present disclosure is directed to a multi-variant control system for an industrial facility. In one form of a method, a processor monitors a behavior of a distributed control system with respect to at least a set of uncontrolled variables, a set of controlled variables, and a set of monitored variables; trains a model based on the monitored behavior utilizing at least one of artificial intelligence or machine learning; and identifies, based on the model, a subset of controlled variables for optimization. Further, the processor monitors a behavior of the industrial facility without the use of the distributed control system; optimizes, based on the monitored behavior, the subset of controlled variables to obtain a target result and restrict variation of values of the set of monitored values; and executes a control system for the industrial facility based on the optimization of the subset of controlled variables.
G05B 13/04 - Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion electric involving the use of models or simulators
G05B 13/02 - Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion electric
The present disclosure provides compositions, methods, and systems related to programmable base editing. In particular, the present disclosure provides novel genome modification technology involving introducing a chemical modification (e.g., a replication-blocking lesion) at a specific target site that blocks DNA replication and results in a site-specific nucleotide mutation. The compositions, methods, and systems described herein facilitate efficient site-specific genome modification of a DNA target, while minimizing the unintended edits and cellular toxicity associated with current genome editing approaches.
The present disclosure provides compositions, systems, and methods related to cellular transduction. In particular, the present disclosure provides compositions, systems, and methods for generating a dry scaffold that facilitates rapid and highly efficient cellular transduction.
The present disclosure provides materials and methods related to the purification of a biologic. The present disclosure provides materials and methods related to the purification of a biologic. In particular, the present disclosure provides a multifunctional chromatography medium comprising porous beads or particles having a defined pore diameter distribution and one or more ligands conjugated to the surface of the pores capable of removing process-related impurities and product-related impurities from a target biologic.
B01D 15/32 - Bonded phase chromatography, e.g. with normal bonded phase, reversed phase or hydrophobic interaction
B01D 15/36 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
The present disclosure provides methods related to the purification of a biologic. In particular, the present disclosure methods for purifying a biologic using a multifunctional chromatography medium comprising porous beads or particles having a defined pore diameter distribution and one or more ligands conjugated to the surface of the pores capable of removing process-related impurities and product-related impurities from a target biologic.
C07K 1/16 - ExtractionSeparationPurification by chromatography
B01D 15/34 - Size-selective separation, e.g. size-exclusion chromatographyGel filtrationPermeation
B01D 15/36 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
The subject matter described herein is directed to cross-linked chitosan hydrogels having desired properties and methods for their preparation and use.
A61K 47/62 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
30.
COMPOSITIONS AND METHODS RELATING TO ENZYMATIC DNA SYNTHESIS
The present disclosure provides compositions and methods related to enzymatic nucleic acid synthesis. In particular, the present disclosure provides novel compositions and methods for generating a plurality of modified nucleic acid oligos using a nucleic acid template molecule.
C12Q 1/6848 - Nucleic acid amplification reactions characterised by the means for preventing contamination or increasing the specificity or sensitivity of an amplification reaction
C12Q 1/6853 - Nucleic acid amplification reactions using modified primers or templates
31.
POLYMERIC FLUOROPHORES, COMPOSITIONS COMPRISING THE SAME, AND METHODS OF PREPARING AND USING THE SAME
Described herein are polymeric fluorophores that include a dye, a polymer, and optionally a bioconjugate group. A polymeric fluorophore may have a structure represented by: A-B-C or C-A-B, wherein A is a dye; B is a polymer comprising one or more hydrophobic unit(s) and one or more hydrophilic unit(s); and optionally C, wherein C, when present, comprises a bioconjugate group. Also described herein are compositions comprising the polymeric fluorophores and methods of preparing and using the same.
C08F 293/00 - Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule
C08L 33/08 - Homopolymers or copolymers of acrylic acid esters
32.
ULTRASOUND TRANSDUCER AND ARRAY FOR INTRAVASCULAR THROMBOLYSIS
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (USA)
Inventor
Jiang, Xiaoning
Kim, Jinwook
Ma, Jianguo
Dai, Xuming
Abstract
A catheter-implemented transducer device for intravascular thrombolysis, is described herein. Such a transducer device includes a catheter defining a longitudinal axis and having opposed proximal and distal ends. At least one ultrasonic transducer arrangement is disposed about the distal end. The ultrasonic transducer arrangement is oriented with acoustic waves propagating parallel or perpendicular to the longitudinal axis. Optionally, the ultrasonic transducer arrangement is configured as a multi-layer stacked structure of ultrasonic transducer elements. Optionally, the ultrasonic transducer arrangement is a laser ultrasonic transducer arrangement. Optionally, the ultrasonic transducer arrangement is configured to operate in a lateral mode.
A61B 17/22 - Implements for squeezing-off ulcers or the like on inner organs of the bodyImplements for scraping-out cavities of body organs, e.g. bonesSurgical instruments, devices or methods for invasive removal or destruction of calculus using mechanical vibrationsSurgical instruments, devices or methods for removing obstructions in blood vessels, not otherwise provided for
A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
A61B 18/22 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibreHand-pieces therefor
A61B 18/26 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibreHand-pieces therefor for producing a shock wave, e.g. laser lithotripsy
33.
PARALLELING POWER SEMICONDUCTORS WITH DIFFERENT SWITCHING FREQUENCIES
Various examples are provided related to operation of parallel semiconductors with different switching frequencies. In one example, a method of reducing conduction and switching losses in a high current switching circuit includes controlling two hybrid switches to conduct concurrently or alternately, each of the hybrid switches include a wide bandgap device and a silicon power device. Controlling of the silicon power device is at a first gate switching frequency and controlling of the wide bandgap device is at a second gate switching frequency, where the first gate switching frequency is lower than the second gate switching frequency. The silicon power device can be switched at a frequency of about 50 or 60 Hertz. The wide bandgap device can be switched at a frequency greater than 1 kHz.
H02M 7/537 - Conversion of DC power input into AC power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only, e.g. single switched pulse inverters
A cargo container system, comprising: a vehicle with a cargo compartment; a cargo container configured to fit within the cargo compartment; and, a weight balance adjustment mechanism, comprising at least one of a load sensor and a position sensor, configured to adjust the position of the cargo container within the cargo compartment using data received from the at least one of a load sensor and a position sensor
G05D 3/20 - Control of position or direction using feedback using a digital comparing device
B62D 33/10 - Superstructures for load-carrying vehicles characterised by the connection of the superstructure to the vehicle frame comprising means for the suspension of the superstructure on the frame
B64D 9/00 - Equipment for handling freightEquipment for facilitating passenger embarkation or the like
B65D 88/14 - Large containers rigid specially adapted for transport by air
35.
METHODS FOR MANUFACTURING METAL OXIDE INFUSED CONFORMAL COATING MATERIAL AND METAL OXIDE INFUSED CONFORMAL COATING MATERIAL MADE USING SAME
A method for manufacturing and applying a metal oxide coating for shielding an object from particle radiation includes heating a quantity of a resin of a polyurethane system and mixing a metal oxide with the quantity of the resin of the polyurethane system to form a mixture. The method further includes mixing a quantity of a hardener of the polyurethane system with the mixture to form a metal oxide infused conformal coating (MOICC). The method further includes applying the MOICC to an object to shield the object from particle radiation and curing the MOICC.
Various examples are provided related to operation of parallel semiconductors with different switching frequencies. In one example, a method of reducing conduction and switching losses in a high current switching circuit includes controlling two hybrid switches to conduct concurrently or alternately, each of the hybrid switches include a wide bandgap device and a silicon power device. Controlling of the silicon power device is at a first gate switching frequency and controlling of the wide bandgap device is at a second gate switching frequency, where the first gate switching frequency is lower than the second gate switching frequency. The silicon power device can be switched at a frequency of about 50 or 60 Hertz. The wide bandgap device can be switched at a frequency greater than 1 kHz.
The present invention relates to tobacco products from plants comprising mutated berberine bridge enzyme-like nucleic acids and the recessive nic1 and/or nic2 alleles and methods of making the same.
A cargo container system, comprising: a vehicle with a cargo compartment; a cargo container configured to fit within the cargo compartment; and, a weight balance adjustment mechanism, comprising at least one of a load sensor and a position sensor, configured to adjust the position of the cargo container within the cargo compartment using data received from the at least one of a load sensor and a position sensor.
G01G 19/08 - Weighing apparatus or methods adapted for special purposes not provided for in groups for incorporation in vehicles
G01G 19/10 - Weighing apparatus or methods adapted for special purposes not provided for in groups for incorporation in vehicles having fluid weight-sensitive devices
G01G 19/12 - Weighing apparatus or methods adapted for special purposes not provided for in groups for incorporation in vehicles having electrical weight-sensitive devices
41 - Education, entertainment, sporting and cultural services
Goods & Services
Educational services, namely, providing career counseling and workforce training for graduate students; educational services, namely providing career placement and preparedness seminars and training for graduate students
41 - Education, entertainment, sporting and cultural services
Goods & Services
Educational services, namely, providing career counseling for graduate students; educational services, namely providing career placement and preparedness seminars for graduate students
Methods and systems for rapid detection of volatile organic compounds (VOCs) from plants, such as onions and other fruits and vegetables, are described. The systems include one or more colorimetric sensing elements and a cell-damaging component that can damage one or more cells in a plant sample to induce VOC release. In an exemplary system, a colorimetric dye array is combined with one or more needles on a single sensor body. Use of the system for classifying onion bulbs based on tearing intensity and/or pungency is described.
G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
G01N 1/22 - Devices for withdrawing samples in the gaseous state
43.
COMPOSITIONS AND METHODS FOR PURIFYING LENTIVIRUS PARTICLES
The present disclosure provides materials and methods related to the purification of viral vectors. In particular, the present disclosure provides peptides, compositions, adsorbents, and related methods, capable of removing process-related impurities (e.g., host cell proteins, nucleic acids, and media components) and product-related impurities (e.g., product fragments, product aggregates, and inactive forms derived from product degradation by or association with other species in the cell culture harvest) from samples during the production and purification of lentivirus particles.
The present disclosure is directed to a multi-variant control system for an industrial facility. In one form of a method, a processor monitors a behavior of a distributed control system with respect to at least a set of uncontrolled variables, a set of controlled variables, and a set of monitored variables; trains a model based on the monitored behavior utilizing at least one of artificial intelligence or machine learning; and identifies, based on the model, a subset of controlled variables for optimization. Further, the processor monitors a behavior of the industrial facility without the use of the distributed control system; optimizes, based on the monitored behavior, the subset of controlled variables to obtain a target result and restrict variation of values of the set of monitored values; and executes a control system for the industrial facility based on the optimization of the subset of controlled variables.
G05B 13/02 - Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion electric
45.
SYSTEMS AND METHODS FOR DETERMINING SLEEP PATTERNS AND CIRCADIAN RHYTHMS
Systems and methods for monitoring sleep are disclosed. According to an aspect, a method includes emitting light into tissue. The method also includes detecting light backscattered from the tissue. Further, the method includes determining a sleep pattern based on the backscattered light.
A61B 5/08 - Measuring devices for evaluating the respiratory organs
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
A61M 21/00 - Other devices or methods to cause a change in the state of consciousnessDevices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
46.
BIOSENSOR AND METHODS OF IN-SITU MEASURING OF NUTRIENT CONTENT OF A CROP CULTIVATION SUBSTRATE
The subject matter described herein is directed to systems, detection devices and enzyme sensors for real-time determination of the concentration levels of nutrients in a crop cultivation substrate using thermal signals and change in enthalpy per unit of enzyme. Methods of using the systems, detection devices and enzyme sensors for agricultural applications are described.
C12N 11/14 - Enzymes or microbial cells immobilised on or in an inorganic carrier
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
C12Q 1/26 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving oxidoreductase
C12Q 1/58 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving urea or urease
G01K 7/02 - Measuring temperature based on the use of electric or magnetic elements directly sensitive to heat using thermoelectric elements, e.g. thermocouples
G01K 7/16 - Measuring temperature based on the use of electric or magnetic elements directly sensitive to heat using resistive elements
47.
HYDROFORMYLATION PROCESS FOR PREPARING LINEAR AND BRANCHED ALDEHYDES
Described are processes for preparing linear and branched aldehydes, which comprises reacting an olefin with hydrogen and carbon monoxide in the presence of a catalyst solution comprising rhodium, a hydroformylation solvent, and a fluorophosphite ligand having the general formula (I).
Described are processes for preparing linear and branched aldehydes, which comprises reacting an olefin with hydrogen and carbon monoxide in the presence of a catalyst solution comprising rhodium, a hydroformylation solvent, and a fluorophosphite ligand having the general formula (I).
C07C 45/50 - Preparation of compounds having C=O groups bound only to carbon or hydrogen atomsPreparation of chelates of such compounds by reaction with carbon monoxide by oxo-reactions
B01J 23/46 - Ruthenium, rhodium, osmium or iridium
The present disclosure provides compositions, methods, and systems related to a dual-affinity ratiometric quenching bioassay. In particular, the present disclosure provides novel compositions and methods that combine selective biorecognition and quenching of fluoescence signals for rapid and sensitive quantification of proteins in complex samples.
G01N 33/542 - ImmunoassayBiospecific binding assayMaterials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses
G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances
49.
SEQUENCING AND STRATEGIES FOR ENHANCING INTRAVASCULAR THROMBUS DISRUPTION WITH PHASE-CHANGE CAVITATION ENHANCING AGENTS
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (USA)
THE REGENTS OF THE UNIVERSITY OF MICHIGAN (USA)
Inventor
Dayton, Paul Alexander
Kim, Jinwook
Jiang, Xiaoning
Zhang, Bohua
Wu, Huaiyu
Xu, Zhen
Abstract
A method for disrupting a blood clot with ultrasound and at least one cavitation enhancing agent includes administering at least one cavitation enhancing agent into a blood vessel of a subject. The method further includes monitoring the at least one cavitation enhancing agent to determine when at least a portion of the at least one cavitation enhancing agent has reached a blood clot. The method further includes controlling application of ultrasound energy to the at least one cavitation enhancing agent within the blood vessel of the subject such that, during a first time period, cavitation-enhancing ultrasound energy is not applied to the at least one cavitation enhancing agent within the blood vessel and, during a second time period after the first time period, cavitation enhancing ultrasound energy is applied to the at least one cavitation enhancing agent within the blood vessel.
A61B 17/22 - Implements for squeezing-off ulcers or the like on inner organs of the bodyImplements for scraping-out cavities of body organs, e.g. bonesSurgical instruments, devices or methods for invasive removal or destruction of calculus using mechanical vibrationsSurgical instruments, devices or methods for removing obstructions in blood vessels, not otherwise provided for
50.
PROTEIN DEGRADATION SYSTEM, COMPONENTS, AND METHODS
The present disclosure provides components and systems for targeted protein degradation in cells (e.g., in plant cells). In particular, the present disclosure provides a protein containing the Leucine-Rich Repeat (LRR) and novel E3 ligase (NEL) domains of SspH1 for use with Homology Region 1b (HR1b) domain of human PKN1 for degrading target proteins.
In one aspect, the disclosure relates to compositions including a collagen hydrogel and a flavonoid, wherein at least a portion of the collagen hydrogel is crosslinked by the flavonoid, methods of making the cosmetic and pharmaceutical compositions comprising the same, and methods of healing wounds using the same. The disclosed compositions are cytocompatible and can protect cells from oxidative damage through preventing damage from and/or reducing accumulation of reactive oxygen species (ROS). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
Compounds comprising a tetrapyrrole macrocycle that includes a radionuclide; a hydrogelator attached to the tetrapyrrole macrocycle; a water solubilizing group attached to the hydrogelator; and a cleavage site that is between the hydrogelator and the water solubilizing group are described herein along with their methods of use. Two or more compounds of the present invention may two or more compounds may self-assemble (e.g., aggregate), optionally in vivo.
A61K 51/12 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes
53.
ENCAPSULATION OF NUTRITIONAL AND/OR COMPOUNDS FOR CONTROLLED RELEASE AND ENHANCING THEIR BIOAVAILABILITY BY LIMITING CHEMICAL OR MICROBIAL EXPOSURE
Described herein are compounds that include a tetrapyrrole macrocycle and a water solubilizing group that is attached to the tetrapyrrole macrocycle along with methods of using the same.
C07D 405/14 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
C07D 487/22 - Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups in which the condensed system contains four or more hetero rings
55.
EFFICIENT RECYCLING OF E-WASTE BY ENERGY LANDSCAPE INVERSION
The present invention provides methods for recovering metals, including rare earth metals, from mixed metals. An example is the recovery of metals from electronic waste. The method of separation is based on the inversion and/or lowering of the thermodynamic energy barrier by using one or more stressors applied at appropriate ratios to create lower energy points in the thermodynamic energy landscape of the mixed metals. Example stressors include a) a chemical stress, b) a mechanical stress, c) a thermal stress, d) and electromagnetic radiation and/or light stress, an interfacial stress, and/or a magnetic flux gradient stress.
A non-shedding hybrid nonwoven web comprised of 99% by mass of functional material(s) co-mingled with the filaments. High level of particle retention within the fabric is provided without the aid of adhesives, binders, adhesive polymers, or post processes. This composite web has a multi-layered structure with a uniform distribution of sorptive particles and desired opposed color contrast on each side. The process includes providing two converging streams of blown polymeric filaments, passive feed of functional material(s) in between the filament streams, and collecting the hybrid webs.
D04H 1/407 - Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties containing absorbing substances, e.g. activated carbon
B01D 39/16 - Other self-supporting filtering material of organic material, e.g. synthetic fibres
D04H 1/56 - Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties by welding together the fibres, e.g. by partially melting or dissolving in association with fibre formation, e.g. immediately following extrusion of staple fibres
D04H 3/16 - Non woven fabrics formed wholly or mainly of yarns or like filamentary material of substantial length characterised by the method of strengthening or consolidating with bonds between thermoplastic yarns or filaments produced by welding with bonds between thermoplastic filaments produced in association with filament formation, e.g. immediately following extrusion
Methods of mineralizing hemp fiber to provide hemp fibers mineralized with calcium carbonate are described. Also described are mineralized hemp fibers and compositions including the mineralized hemp fibers. The mineralized hemp fibers can be hemp fibers with calcium carbonated deposited on the hemp fiber surface. The compositions including the mineralized hemp fibers can be cementitious or non-cementitious. Also described are methods of preparing “green” concrete comprising mineralized hemp.
The present disclosure provides compositions and methods related to tobacco plants. In particular, the present disclosure provides novel methods for producing tobacco plants, and any related tobacco products, having low nicotinic alkaloid content. Tobacco plants produced according to the methods of the present disclosure exhibit reduced levels of nicotinic alkaloids (e.g., nicotine) compared to both naturally-occurring and transgenic tobacco plants, and thus represent a commercially valuable alternative to currently available tobacco varieties.
The loss of cross-linking abilities in highly substituted alginate scaffolds is a significant problem affecting the use of alginate polymers in implants, cell delivery, and tissue engineering. Disclosed are modified alginate scaffolds that retain their gelation properties under high chemical modification, as well as methods of making and using thereof.
An exemplary left ventricular assist device (LVAD) and method that employs design and material designs to reduce the thrombosis risk of LVAD implant in a patient. One feature of the design includes a stented inlet member for the device that can reduce or fully eliminate a flow stasis that can trigger blood protein adsorption that can lead to chain reactions that then result in thrombosis. Other features of the design include (i) a flexible rotor and/or pump housing that can reduce blood damage, (ii) hydrophilic slippery coatings at high sheer components, such as the rotor to further reduce protein adsorption and thus thrombosis risk, (iii) magnetic-based drive and bearing components that can improve the hemocompatibility of the blood pump, and (iv) advanced controls and charging.
A61M 60/178 - Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient’s body implantable in, on, or around the heart drawing blood from a ventricle and returning the blood to the arterial system via a cannula external to the ventricle, e.g. left or right ventricular assist devices
A61M 60/216 - Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller
A61M 60/861 - Connections or anchorings for connecting or anchoring pumps or pumping devices to parts of the patient’s body
63.
DISCOVERY OF DOUBLE HELIX AND IMPACT ON NANOSCALE TO MESOSCALE CRYSTALLINE STRUCTURES
Screw dislocations play a significant role in the growth of crystalline structures by providing a continuous source of surface steps, which represent available sites for crystal growth. Here we show that pure screw dislocations can become helical by the absorption of defects (e.g., vacancies), and develop attractive interaction with another helical dislocation to form a double helix of screw dislocations. These single and double helix of screw dislocations can result in the formation of interesting nanostructures with large Eshelby twists. Examples of the formation of a double helix during thermal annealing of screw dislocations in magnesium oxide are presented. These large effective Burgers also unravel the mechanism for the formation of nanopipes and micropipes with hollow cores and nanotubes with Eshelby twists in technologically important materials, such as SiC, GaN and ZnO that are utilized in a variety of advanced solid state devices.
This invention relates to methods for increasing phage resistance in Clostridium species through incorporation of novel recombinant Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) RNAs using endogenous CRISPR systems and/or recombinant nucleic acid constructs encoding clostridia Type I-B and Type I-C CASCADE complexes, and/or expression cassettes and vectors comprising the same.
In one aspect, the disclosure relates to catalytic phase transfer sorbents (PTS) for producing hydrogen-enriched syngas from a carbonaceous feedstock, the PTS comprising a formula selected from ABO3 and An+1BnO3n+1, wherein A comprises one or more alkali metals or alkaline earth metals, wherein B comprises one or more transition metals, and wherein X comprises an anion. Also disclosed is a system for hydrogen generation from carbonaceous feedstocks, the system comprising a gasifier unit for production of H2-rich syngas and a regenerator unit for regeneration of spent PTS. Further disclosed herein is a method for hydrogen generation from carbonaceous feedstocks using the disclosed systems. The disclosed systems can be operated isothermally through 10 or more cycles without degradation in performance, while the disclosed methods can yield 50% or more H2 relative to carbon-containing species. In some aspects, the methods produce little to no CO2.
B01J 8/26 - Chemical or physical processes in general, conducted in the presence of fluids and solid particlesApparatus for such processes with fluidised particles according to "fluidised-bed" technique with two or more fluidised beds, e.g. reactor and regeneration installations
B01J 8/18 - Chemical or physical processes in general, conducted in the presence of fluids and solid particlesApparatus for such processes with fluidised particles
B01J 20/06 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising oxides or hydroxides of metals not provided for in group
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
B01J 23/92 - Regeneration or reactivation of catalysts comprising metals, oxides or hydroxides provided for in groups
B01J 35/40 - Catalysts, in general, characterised by their form or physical properties characterised by dimensions, e.g. grain size
B01J 38/30 - Treating with free oxygen-containing gas in gaseous suspension, e.g. fluidised bed
C01B 3/44 - Production of hydrogen or of gaseous mixtures containing hydrogen by reaction of gaseous or liquid organic compounds with gasifying agents, e.g. water, carbon dioxide, air by reaction of hydrocarbons with gasifying agents using catalysts using moving solid particles using the fluidised bed technique
The disclosure relates to nonwoven fabric including a nonwoven material having a first surface and an opposing second surface, wherein the first surface has a first average surface charge and the second surface has a second average surface charge, the first average surface charge being different from the second average surface charge, wherein the nonwoven material includes a first plurality of fibers including a first polymer and a second plurality of fibers including a second polymer different from the first polymer. A method for imparting surface charge to a nonwoven N61824_1570Wabric is also provided.
D04H 1/492 - Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties the fleeces or layers being consolidated by mechanical means, e.g. by rolling by needling or like operations to cause entanglement of fibres by fluid jet
D04H 1/56 - Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties by welding together the fibres, e.g. by partially melting or dissolving in association with fibre formation, e.g. immediately following extrusion of staple fibres
D04H 3/11 - Non woven fabrics formed wholly or mainly of yarns or like filamentary material of substantial length characterised by the method of strengthening or consolidating with bonds between yarns or filaments made mechanically by fluid jet
D04H 3/16 - Non woven fabrics formed wholly or mainly of yarns or like filamentary material of substantial length characterised by the method of strengthening or consolidating with bonds between thermoplastic yarns or filaments produced by welding with bonds between thermoplastic filaments produced in association with filament formation, e.g. immediately following extrusion
67.
BIOORTHOGONAL CATALYTIC PATCH AND METHODS OF USING THE SAME
A bioorthogonal catalytic patch integrates TiO2 nanosheets populated with metallic nanoparticles into polyvinyl alcohol-based microneedles arranged in an array. This bioorthogonal patch-based device is robust, removable and can effectively mediate the conversion of caged substrates into their active states once placed at the site of application. The capacity of the patch in executing bioorthogonal catalysis in high-level living systems was demonstrated by localized dealkylation of a caged doxorubicin prodrug at the melanoma tumor site and restoration of its pharmacological properties for cancer therapy. This in situ applied patch facilitated to enhance the local treatment efficacy and eliminate off-targeted prodrug activation or dose-dependent side effect towards healthy organs or tissues located away from the application site.
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 31/704 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin, digitoxin
The present disclosure provides materials and methods related to the purification of viral vectors. In particular, the present disclosure provides compositions, and related methods, comprising peptide ligands capable of removing process-related impurities (e.g., host cell proteins, nucleic acids, and media components) and product-related impurities (e.g., product fragments, product aggregates, and inactive forms derived from product degradation by or association with other species in the cell culture harvest) from biological fluids during the production and purification of adeno-associated viruses (AAVs).
Disclosed herein are thrombin-sensitive platelet like particles. The particles can be used to promote healing in a variety of wounds and can be used in drug delivery systems.
A61L 26/00 - Chemical aspects of, or use of materials for, liquid bandages
A61P 17/02 - Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
C08L 33/26 - Homopolymers or copolymers of acrylamide or methacrylamide
University of Pittsburgh - Of the Commonwealth System of Higher Education (USA)
North Carolina State University (USA)
Blatek Industries, Inc. (USA)
Inventor
Kang, Kim
Chen, Qiyang
Sheng, Zhiyu
Zhang, Bohua
Kim, Howuk
Wu, Huaiyu
Jiang, Xiaoning
Chen, Mengyue
Geng, Xuecang
Abstract
Ultrasound systems and methods of use are provided for rapidly heating a target area of a subject. The ultrasound system can include at least one imaging transducer array for imaging the target area, and at least two spaced-apart heating transducer arrays for heating the target area. The heating transducer arrays can be separated by the imaging transducer array on an ultrasound probe.
This invention is directed to recombinant Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and recombinant nucleic acid constructs encoding clostridia Type I-B CASCADE complexes, expression cassettes and vectors comprising the same, and methods of use thereof for modifying genomes, altering expression, killing one or more cells in a population of cells, and screening or selecting for genomic variants of an organism.
‘XZ 14069’ is a medium to dark green perennial zoysiagrass cultivar with medium-fine texture low incidence of large patch disease and aggressive stoloniferous growth producing high density turf performance ideal for low-management landscaping. It is distinguishable from other cultivars by medium-fine texture, plant architecture and characteristics such as high drought tolerance, turf quality, disease resistance and aggressive establishment from minimal input. ‘XZ 14069’ shows persistence under an array of climates including warm-temperate, warm-humid and hot-arid. ‘XZ 14069’ is also genetically distinct from other zoysiagrass cultivars currently in the marketplace known to the Inventor. ‘XZ 14069’ exhibits very low fertility and no inflorescences have been observed.
Various examples are provided related to monitoring of various biomarkers in wound fluid to indicate a wound status. In one example, a wound sensing system includes a platform for examining a wound; and an array of sensors disposed on the platform. The array of sensors can include one or more fluorometric assay sensor, one or more colorimetric assay sensor, or both. Each of the fluorometric assay sensor can produce a fluorescence intensity proportional to a corresponding target concentration and each of the colorimetric sensor can produce a color change proportional to a corresponding target concentration. In another example, a method includes swiping a wound with an array of sensors of a wound sensing system; waiting for a predetermined amount of time; capturing an image of the of the array of sensors; and analyzing the image to determine one or more analyte concentration based upon fluorescence intensity, color intensity or both.
‘NCORNSP-031SHMG’ is a moderately compact and loosely upright variety with a moderate growth rate and is well branched. It is distinguishable from other ornamental sweetpotato cultivars by its dark red heart shaped leaves, a moderately-compact habit and semi-erect mounding plant architecture. The dark red leaves, uniform color, short internodes, and the plant architecture, which promotes good plant production in the greenhouse for wholesale distributors, distinguishes ‘NCORNSP-031SHMG’ amongst the current ornamental sweetpotatoes in the marketplace. In greenhouse and field trials, ‘NCORNSP-031SHMG’ is shown to be suitable for use as a landscape or containerized plant.
‘NCORNSP-032SCRHI’ is a moderately compact and loosely upright variety with a moderate growth rate and is well branched. It is distinguishable from other ornamental sweetpotato cultivars by its red to burgundy five lobed leaves, a moderately-compact habit and semi-erect mounding plant architecture. The burgundy leaves, uniform color, short internodes, and the plant architecture, which promotes good plant production in the greenhouse for wholesale distributors, distinguishes ‘NCORNSP-032SCRHI’ amongst the current ornamental sweetpotatoes in the marketplace. In greenhouse and field trials, ‘NCORNSP-032SCRHI’ is shown to be suitable for use as a landscape or containerized plant. The production of flowers by ‘NCORNSP-032SCRHI’ is not observed under short-day conditions.
An exemplary method for producing a strain sensor using crack propagation includes opening and blunting includes applying conductive nanowires to a substrate to form a conductive nanowire network on the substrate. The method also includes applying an elastomer to the nanowire network to form a composite layer on top of the conductive nanowire network. The method also includes removing the substrate from the conductive nanowire network, wherein removing the substrate at least partially exposes a surface of the conductive nanowire network. The method further includes cutting intervallic incisions in the surface of the conductive nanowire network, wherein the intervallic incisions extend alternatingly and inwardly from one of two opposing edges of the conductive nanowire network.
G01B 7/16 - Measuring arrangements characterised by the use of electric or magnetic techniques for measuring the deformation in a solid, e.g. by resistance strain gauge
Various examples are provided related to Q-silicon, Q-carbon and combinations thereof, and synthesis, properties and applications of Q-silicon and Q-carbon. In one example, a method includes forming a layer of amorphous silicon; melting at least a portion of the layer of amorphous silicon in an undercooled state; and forming Q-silicon by quenching the melted amorphous silicon from the undercooled state. In another example, a Q-silicon includes a random arrangement of tetrahedra, the tetrahedra including dangling bonds, unpaired spins or both. The atomic structure of the Q-silicon is based upon time in an undercooled state before quenching. In another example, a battery anode includes Q-silicon mixed with a polyvinylidene difluoride (PVDF) binder, the Q-silicon including a random arrangement of tetrahedra, the tetrahedra comprising dangling bonds, unpaired spins or both. The battery anode can include Q-carbon and Q-silicon mixed with the PVDF binder.
The present invention provides wearable plant sensors for continuous monitoring of plant physiology by tracking both biochemical and biophysical signals of the plant and its microenvironment. Sensors for detecting volatile organic compounds (VOC), temperature, and humidity are integrated into a single platform. The abaxial leaf attachment position is selected based on the stomata density to improve the sensor signal strength. This versatile platform enables various stress monitoring applications, ranging from tracking plant water loss to early detection of plant pathogens. A machine learning model was also developed to analyze multichannel sensor data for quantitative detection of tomato spotted wilt virus (TSWV) as early as four days after inoculation.
Sustainable paper-based packaging materials, e.g., paper-based food packaging materials, are described. The packaging materials are based on paper formed from fiber derived from waste biomass, such as hemp hurds, mixes containing hemp hurds and hemp bast fibers, bagasse, and cocoa pod husks. Also described are methods of making the packaging materials. The methods can include environmentally friendly pulping and/or bleaching processes.
D21F 11/02 - Processes for making continuous lengths of paper, or of cardboard, or of wet web for fibreboard production, on paper-making machines of the Fourdrinier type
A voice therapy device including a body having an internal passageway with a longitudinal axis that defines an airflow direction; a mouthpiece positioned at a proximal end of the body; and a resistance portion positioned at a distal end of the body, where the resistance portion is adjustable to vary an airflow resistance through the internal passageway. In some embodiments, the voice therapy device includes a sensor electrically coupled to a processor. A system for voice therapy includes the voice therapy device and a software application.
A transparent structure (40) for emitting light is described. The transparent structure comprises an emissive layer (EML) (44) positioned between first (46) and second (42) electrodes. The EML (44) is tuned such that luminance through the first electrode (46) is greater than luminance through the second electrode (42).
H01L 21/18 - Manufacture or treatment of semiconductor devices or of parts thereof the devices having potential barriers, e.g. a PN junction, depletion layer or carrier concentration layer the devices having semiconductor bodies comprising elements of Group IV of the Periodic Table or AIIIBV compounds with or without impurities, e.g. doping materials
H01L 29/20 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only AIIIBV compounds
H01L 29/205 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only AIIIBV compounds including two or more compounds in different semiconductor regions
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (USA)
Inventor
Gilger, Brian
Crabtree, Elizabeth
Hirsch, Matthew L.
Abstract
The present disclosure provides compositions and methods related to the treatment of ocular diseases in equines. In particular, the present disclosure provides novel compositions and methods related to the administration of therapeutic compositions comprising AAV-equine IL-10 for the treatment and/or prevention of various ocular diseases (e.g., non-infectious uveitis).
A transparent structure for emitting light is described. The transparent structure comprises an emissive layer (EML) positioned between first and second electrodes. The EML is tuned such that luminance through the first electrode is greater than luminance through the second electrode.
The present disclosure provides compositions, methods, and kits related to DNA transformation in bacteria. In particular, the present disclosure provides novel compositions and methods for enhancing DNA transformation by replicating a DNA methylation pattern used in a bacterial host strain. The compositions, methods, and systems described herein utilize cell-free transcription-translation mixtures and DNA methylation complexes to increase transformation efficiency and efficacy for any bacterial host.
The present disclosure provides compositions and methods related to nucleic acid molecules having therapeutic activity. In particular, the present disclosure provides nucleic acid molecules comprising one or more aptamers having anticoagulant activity, as well as corresponding antidote nucleic acid molecules capable of modulating anticoagulant activity.
The present disclosure relates generally to test devices comprising a round window membrane and/or an oval window membrane separating two compartments and to the use of such devices in methods for identifying compounds and compositions suitable for use as therapeutics via intratympanic administration.
In one aspect, the disclosure relates to a method for removing a hyperpolarization catalyst from a solution comprising a hyperpolarized molecule, the method including at least the step of filtering the solution using a silica-based sorbent such as a normal phase, reverse phase, or ion exchange silica-based sorbent. In an aspect, the hyperpolarization catalyst includes a metal center such as Ir, Rh, Co, Fe, Ru, Pd, or Ni. In any of these aspects, the hyperpolarized molecule includes at least one hyperpolarized nucleus selected from 1H, 15N, 13C, or a combination thereof, wherein the nucleus has been hyperpolarized using signal amplification by reversible exchange. In another aspect, the filtration step separates the hyperpolarization catalyst from the hyperpolarized molecule based on at least one differing property. Also disclosed are biocompatible contrast agents containing the hyperpolarized molecules and methods of imaging using the same.
B01J 20/10 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate
B01D 53/14 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by absorption
B01J 8/00 - Chemical or physical processes in general, conducted in the presence of fluids and solid particlesApparatus for such processes
92.
MAGNETIC FIELD CONTROL OF SABRE HYPERPOLARIZED MOLECULES FOR PROCESSING AND ADMINISTRATION
In one aspect, the disclosure relates to a method for conserving hyperpolarization in a hyperpolarized molecule undergoing at least one processing step, the method including conducting the at least one processing step in a magnetic field having a magnetic field strength higher than the magnetic field strength of Earth. In an aspect, prior to the at least one processing step but following hyperpolarization, the molecule can be transferred into a processing magnetic field in an adiabatic manner. In still another aspect, following the processing step, the molecule can be transferred into a signal detection magnetic field in an adiabatic manner. Prior to performing the method, the hyperpolarized molecule can be produced using signal amplification by reversible exchange (SABRE). Also disclosed herein are hyperpolarized molecules prepared by the disclosed methods, contrast agents comprising the same, and methods for diagnosing a disease or monitoring the progress of disease treatment using the same.
A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
G01R 33/28 - Details of apparatus provided for in groups
G01R 33/56 - Image enhancement or correction, e.g. subtraction or averaging techniques
93.
OXIDE-MOLTEN SALT COMPOSITES FOR HIGH-PERFORMANCE THERMAL ENERGY STORAGE
In one aspect, the disclosure relates to an oxide-molten salt (OMS) composite material offering excellent energy storage capacity at low cost. The OMS composite material can be provided in at least three forms, including a porous, perovskite-oxide particle as a matrix having pores filled with unary salt or salt mixtures; an external shell of perovskite-oxide particles and an internal core of salt or a salt mixture; and/or a porous, perovskite-oxide particle as a matrix filled with unary salt or salt mixtures, wherein the whole particle is enclosed with an oxide outer shell. Further in this aspect, the outer shell can be dense but either mixed ionic-electronically conductive or porous. In another aspect, the disclosed methods and systems can be used for grid-scale energy storage by retrofitting existing steam turbine-based power plants and concentrated solar plants. In a further aspect, the disclosed methods, systems, and materials are environmentally benign.
Suspensions include an aqueous medium and a plurality of particles. The particles include polymeric carrier material dispersed throughout the particle and active ingredient dispersed throughout the particle. The polymeric carrier material can be biodegradable, and one example is a cellulose ester. Exemplary active ingredients include an insecticide, a fungicide, and a pesticide. In some instances, the plurality of particles have an average diameter of 25 nm to 5 μm. Exemplary suspensions may be applied to plant surfaces.
A01N 43/40 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
Exemplary catalysts may comprise a two-dimensional substrate and at least one organometallic compound bonded to the two-dimensional substrate. The at least one organometallic compound may comprise a carbonyl group. Exemplary methods of preparing a polymer product may comprise combining a catalyst with an alcohol and an ester in a solvent, thereby generating a mixture, and obtaining the polymer product from the mixture.
B01J 31/12 - Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing organo-metallic compounds or metal hydrides
Various examples are provided related to resonance tracking broadband energy harvesting. In one example, a resonance tracking energy harvester includes a pendulum adaptive frequency oscillator including an adjustable pendulum rod and control circuitry that can adjust a length of the adjustable pendulum rod in response to a sensed forcing frequency. In another example, a method of resonance tracking energy harvesting, includes sensing a forcing frequency applied to a pendulum adaptive frequency oscillator comprising an adjustable pendulum rod; and adjusting a length of the adjustable pendulum rod in response to the sensed forcing frequency. Oscillation and/or vibration of the pendulum adaptive frequency oscillator can be converted.
H02N 2/18 - Electric machines in general using piezoelectric effect, electrostriction or magnetostriction producing electrical output from mechanical input, e.g. generators
G05D 3/12 - Control of position or direction using feedback
97.
COMPOSITIONS AND METHODS FOR TREATING PAIN IN ANIMALS
The present disclosure provides compositions and methods related to the treatment and/or reduction of pain in an animal. In particular, the present disclosure provides novel compositions and methods for treating and/or reducing pain in an animal (e.g., a pig) by administering an analgesic intranasally. The composition and methods described herein provide a more convenient and effective means for treating and/or reducing pain in an animal (e.g., pain associated with industrial processing) in a manner that also improves the animal's health and welfare.
The present disclosure provides a nonwoven material including a blend of a first plurality of monocomponent fibers and a second plurality of segmented fibers having segments of a first polymer and segments of a second polymer different from the first polymer, wherein the nonwoven material includes about 75 to about 95% by weight of the monocomponent fibers, and about 5 to about 25% by weight of the segmented fibers, based on the total weight of the nonwoven material, and wherein the segmented fibers are at least partially fibrillated or split. An air filter including the nonwoven material is also provided.
B01D 29/03 - Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups Filtering elements therefor with flat filtering elements self-supporting
D01F 6/06 - Monocomponent man-made filaments or the like of synthetic polymersManufacture thereof from homopolymers obtained by reactions only involving carbon-to-carbon unsaturated bonds from polyolefins from polypropylene
D01F 8/14 - Conjugated, i.e. bi- or multicomponent, man-made filaments or the likeManufacture thereof from synthetic polymers with at least one polyester as constituent
99.
POPULATION GENETICS APPROACH TO BIOLOGICAL CONTROL OF MYCOTOXIN PRODUCTION
The invention relates to methods for controlling mycotoxin production in field populations of heterothallic and homothallic filamentous fungi through application of biocontrol compositions comprising selected strains of the heterothallic and homothallic filamentous fungi, the selected strains having a lineage of low mycotoxin production or no mycotoxin production and having opposite mating types (heterothallic) or both mating types (homothallic) (e.g., MAT1-1, MAT1-2).
A device can automatically count, speciate, and determine infectivity of eggs of parasites in food animals. The device can include a chamber that can receive a sample specimen. Additionally, the device can include a light source. The light source can illuminate a field of view of the sample specimen in the chamber. The device can further include a microscope objective to magnify the field of view of the sample specimen. The device can include a camera. The camera can image the field of view of the sample specimen. The camera can further produce an on-site dataset of images. Additionally, the camera can provide the on-site dataset of images to a trained machine-learning model for analysis of at least one species of parasites.
C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
