A wearable ultrasound device may include an array of ultrasound transducers, wherein each ultrasound transducer comprises: a matching layer on a top side, an active layer adjacent the matching layer, a first backing layer adjacent the active layer, a second backing layer adjacent the first backing layer; and an epoxy bonding material interspaced between each of the matching layer, the active layer, the first backing layer, and the second backing layer, wherein the array of ultrasound transducers is surrounded by a PDMS filling, whereby the active layer is configured to communicate a signal in response to mechanical deformation.
The present disclosure provides compositions and methods related to opioid detection. In particular, the present disclosure provides aptamer-based colorimetric assays for the visualization and identification of specific opioids (natural, semi-synthetic, synthetic and the derivatives and analogs thereof) in a manner that is rapid, specific, and sensitive.
C12N 15/115 - Aptamères, c.-à-d. acides nucléiques liant spécifiquement une molécule cible avec une haute affinité sans s'y hybrider
G01N 33/58 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des substances marquées
G01N 33/94 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des narcotiques
3.
Ceramic Substrate Windings for Permanent Magnet Machines
Various examples are provided related to ceramic substrate windings and their application. In one example, a ceramic substrate coil includes a ceramic substrate and at least one coil trace disposed on a first surface of the ceramic substrate, the at least one coil trace forming at least a partial loop about the ceramic substrate surface. In another example, a permanent magnet machine includes a rotor and a stator including ceramic coils. Each of the ceramic coils include a ceramic substrate and at least one coil trace disposed on a first surface of the ceramic substrate. The ceramic coils are positioned, and the coil traces are connected to form a stator winding of the permanent magnet machine.
H02K 3/26 - Enroulements caractérisés par la configuration, la forme ou le genre de construction du conducteur, p. ex. avec des conducteurs en barre constitués par des conducteurs imprimés
H02K 3/02 - Enroulements caractérisés par le matériau constituant le conducteur
H02K 9/19 - Dispositions de refroidissement ou de ventilation pour machines avec enveloppe fermée et circuit fermé de refroidissement utilisant un agent de refroidissement liquide, p. ex. de l'huile
H02K 9/22 - Dispositions de refroidissement ou de ventilation par un matériau solide conducteur de la chaleur s'encastrant dans, ou mis en contact avec, le stator ou le rotor, p. ex. des ponts de chaleur
4.
CLEAN LABEL ACCELERATED AGING PROCESS FOR DISTILLED SPIRITS
Disclosed herein is a method for accelerating aging of a beverage, the method comprising exposing the beverage to wood in a water bath at a temperature from 125°F-141°F for 14 to 28 days. Also disclosed is a kit for accelerating aging of a beverage, wherein the kit comprises wood designed for flavoring beverages and a kettle comprising a water bath. Further disclosed is an alcoholic beverage, wherein said beverage has been aged for less than 60 days, and wherein said beverage has a concentration of isoamyl alcohol of less than 200,000 µg/L, a concentration of ethyl decanoate of greater than 2,000 µg/L, and a concentration of syringol between 100 and 1,000 µg/L.
C12G 3/07 - Aromatisation avec des extraits de bois, p. ex. obtenue par le contact avec le boisPrétraitement du bois utilisé à cet effet
C12G 3/08 - Préparation d'autres boissons alcoolisées par des procédés de modification de la composition des solutions fermentées ou des boissons alcoolisées non prévues dans les groupes
C12H 1/18 - Pasteurisation, stérilisation, conservation, purification, clarification ou vieillissement des boissons alcoolisées sans précipitation par des moyens physiques, p. ex. irradiation par chauffage
5.
ATOMIC LAYER ETCHING OF METALS USING NOVEL CO-REACTANTS AS HALOGENATING AGENTS
The disclosed and claimed subject matter relates to thermal atomic layer etch (ALE) processing of metals and alloys thereof (e.g., cobalt and cobalt alloys) using thionyl chloride (SOCl2) or a combination of thionyl chloride and pyridine.
The present disclosure is directed to a multi-variant control system for an industrial facility. In one form of a method, a processor monitors a behavior of a distributed control system with respect to at least a set of uncontrolled variables, a set of controlled variables, and a set of monitored variables; trains a model based on the monitored behavior utilizing at least one of artificial intelligence or machine learning; and identifies, based on the model, a subset of controlled variables for optimization. Further, the processor monitors a behavior of the industrial facility without the use of the distributed control system; optimizes, based on the monitored behavior, the subset of controlled variables to obtain a target result and restrict variation of values of the set of monitored values; and executes a control system for the industrial facility based on the optimization of the subset of controlled variables.
G05B 13/04 - Systèmes de commande adaptatifs, c.-à-d. systèmes se réglant eux-mêmes automatiquement pour obtenir un rendement optimal suivant un critère prédéterminé électriques impliquant l'usage de modèles ou de simulateurs
G05B 13/02 - Systèmes de commande adaptatifs, c.-à-d. systèmes se réglant eux-mêmes automatiquement pour obtenir un rendement optimal suivant un critère prédéterminé électriques
The present disclosure provides compositions, methods, and systems related to programmable base editing. In particular, the present disclosure provides novel genome modification technology involving introducing a chemical modification (e.g., a replication-blocking lesion) at a specific target site that blocks DNA replication and results in a site-specific nucleotide mutation. The compositions, methods, and systems described herein facilitate efficient site-specific genome modification of a DNA target, while minimizing the unintended edits and cellular toxicity associated with current genome editing approaches.
C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
The present disclosure provides compositions, systems, and methods related to cellular transduction. In particular, the present disclosure provides compositions, systems, and methods for generating a dry scaffold that facilitates rapid and highly efficient cellular transduction.
C12N 15/87 - Introduction de matériel génétique étranger utilisant des procédés non prévus ailleurs, p. ex. co-transformation
C12N 5/02 - Propagation de cellules individuelles ou de cellules en suspensionLeur conservationMilieux de culture à cet effet
C12N 5/0783 - Cellules TCellules NKProgéniteurs de cellules T ou NK
C12M 3/02 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus comportant des moyens fournissant des suspensions
C12N 15/02 - Préparation de cellules hybrides par fusion de plusieurs cellules, p. ex. fusion de protoplastes
C12N 15/62 - Séquences d'ADN codant pour des protéines de fusion
C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
9.
CHROMATOGRAPHY MEDIUM FOR PURIFYING TARGET BIOLOGICS
The present disclosure provides materials and methods related to the purification of a biologic. The present disclosure provides materials and methods related to the purification of a biologic. In particular, the present disclosure provides a multifunctional chromatography medium comprising porous beads or particles having a defined pore diameter distribution and one or more ligands conjugated to the surface of the pores capable of removing process-related impurities and product-related impurities from a target biologic.
B01J 20/283 - Absorbants ou adsorbants poreux à base de silice
B01D 15/32 - Chromatographie en phase liée, p. ex. avec une phase normale liée, une phase inverse ou une interaction hydrophobe
B01D 15/36 - Adsorption sélective, p. ex. chromatographie caractérisée par le mécanisme de séparation impliquant une interaction ionique, p. ex. échange d'ions, paire d'ions, suppression d'ions ou exclusion d'ions
B01D 15/38 - Adsorption sélective, p. ex. chromatographie caractérisée par le mécanisme de séparation impliquant une interaction spécifique non couverte par un ou plusieurs des groupes , p. ex. chromatographie d'affinité, chromatographie d'échange par ligand ou chromatographie chirale
B01J 20/28 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtrationAbsorbants ou adsorbants pour la chromatographieProcédés pour leur préparation, régénération ou réactivation caractérisées par leur forme ou leurs propriétés physiques
The present disclosure provides methods related to the purification of a biologic. In particular, the present disclosure methods for purifying a biologic using a multifunctional chromatography medium comprising porous beads or particles having a defined pore diameter distribution and one or more ligands conjugated to the surface of the pores capable of removing process-related impurities and product-related impurities from a target biologic.
C07K 1/16 - ExtractionSéparationPurification par chromatographie
B01D 15/34 - Séparation par sélection en fonction de la taille, p. ex. chromatographie d'exclusion de tailleFiltration sur gelPerméation
B01D 15/36 - Adsorption sélective, p. ex. chromatographie caractérisée par le mécanisme de séparation impliquant une interaction ionique, p. ex. échange d'ions, paire d'ions, suppression d'ions ou exclusion d'ions
The subject matter described herein is directed to cross-linked chitosan hydrogels having desired properties and methods for their preparation and use.
A61K 47/62 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant une protéine, un peptide ou un acide polyaminé
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
12.
COMPOSITIONS AND METHODS RELATING TO ENZYMATIC DNA SYNTHESIS
The present disclosure provides compositions and methods related to enzymatic nucleic acid synthesis. In particular, the present disclosure provides novel compositions and methods for generating a plurality of modified nucleic acid oligos using a nucleic acid template molecule.
C12Q 1/6848 - Réactions d’amplification d’acides nucléiques caracterisées par les moyens d’empêcher la contamination ou d’augmenter la spécificité ou la sensibilité d’une réaction d’amplification
C12Q 1/6853 - Réactions d’amplification d’acides nucléiques utilisant des amorces ou des matrices modifiées
13.
POLYMERIC FLUOROPHORES, COMPOSITIONS COMPRISING THE SAME, AND METHODS OF PREPARING AND USING THE SAME
Described herein are polymeric fluorophores that include a dye, a polymer, and optionally a bioconjugate group. A polymeric fluorophore may have a structure represented by: A-B-C or C-A-B, wherein A is a dye; B is a polymer comprising one or more hydrophobic unit(s) and one or more hydrophilic unit(s); and optionally C, wherein C, when present, comprises a bioconjugate group. Also described herein are compositions comprising the polymeric fluorophores and methods of preparing and using the same.
C08F 293/00 - Composés macromoléculaires obtenus par polymérisation sur une macromolécule contenant des groupes capables d'amorcer la formation de nouvelles chaînes polymères rattachées exclusivement à une ou aux deux extrémités de la macromolécule de départ
C08L 33/08 - Homopolymères ou copolymères des esters de l'acide acrylique
14.
ULTRASOUND TRANSDUCER AND ARRAY FOR INTRAVASCULAR THROMBOLYSIS
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (USA)
Inventeur(s)
Jiang, Xiaoning
Kim, Jinwook
Ma, Jianguo
Dai, Xuming
Abrégé
A catheter-implemented transducer device for intravascular thrombolysis, is described herein. Such a transducer device includes a catheter defining a longitudinal axis and having opposed proximal and distal ends. At least one ultrasonic transducer arrangement is disposed about the distal end. The ultrasonic transducer arrangement is oriented with acoustic waves propagating parallel or perpendicular to the longitudinal axis. Optionally, the ultrasonic transducer arrangement is configured as a multi-layer stacked structure of ultrasonic transducer elements. Optionally, the ultrasonic transducer arrangement is a laser ultrasonic transducer arrangement. Optionally, the ultrasonic transducer arrangement is configured to operate in a lateral mode.
A61B 17/22 - Instruments pour comprimer les ulcères ou similaires placés sur les organes internes du corpsInstruments pour curer les cavités des organes du corps, p. ex. des osInstruments, dispositifs ou procédés chirurgicaux pour l'élimination ou la destruction invasives des calculs utilisant des vibrations mécaniquesInstruments, dispositifs ou procédés chirurgicaux pour l'élimination non prévue ailleurs des obstructions dans les vaisseaux sanguins
A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
A61B 18/22 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par application de radiations électromagnétiques, p. ex. de micro-ondes en utilisant des lasers le faisceau étant dirigé le long, ou à l'intérieur d'un conduit flexible, p. ex. d'une fibre optiquePièces à main à cet effet
A61B 18/26 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par application de radiations électromagnétiques, p. ex. de micro-ondes en utilisant des lasers le faisceau étant dirigé le long, ou à l'intérieur d'un conduit flexible, p. ex. d'une fibre optiquePièces à main à cet effet pour produire une onde de choc, p. ex. lithotritie par laser
15.
PARALLELING POWER SEMICONDUCTORS WITH DIFFERENT SWITCHING FREQUENCIES
Various examples are provided related to operation of parallel semiconductors with different switching frequencies. In one example, a method of reducing conduction and switching losses in a high current switching circuit includes controlling two hybrid switches to conduct concurrently or alternately, each of the hybrid switches include a wide bandgap device and a silicon power device. Controlling of the silicon power device is at a first gate switching frequency and controlling of the wide bandgap device is at a second gate switching frequency, where the first gate switching frequency is lower than the second gate switching frequency. The silicon power device can be switched at a frequency of about 50 or 60 Hertz. The wide bandgap device can be switched at a frequency greater than 1 kHz.
H02M 1/00 - Détails d'appareils pour transformation
H02M 7/537 - Transformation d'une puissance d'entrée en courant continu en une puissance de sortie en courant alternatif sans possibilité de réversibilité par convertisseurs statiques utilisant des tubes à décharge avec électrode de commande ou des dispositifs à semi-conducteurs avec électrode de commande utilisant des dispositifs du type triode ou transistor exigeant l'application continue d'un signal de commande utilisant uniquement des dispositifs à semi-conducteurs, p. ex. onduleurs à impulsions à un seul commutateur
A cargo container system, comprising: a vehicle with a cargo compartment; a cargo container configured to fit within the cargo compartment; and, a weight balance adjustment mechanism, comprising at least one of a load sensor and a position sensor, configured to adjust the position of the cargo container within the cargo compartment using data received from the at least one of a load sensor and a position sensor
G05D 3/20 - Commande de la position ou de la direction utilisant la contre-réaction utilisant un dispositif de comparaison numérique
B62D 33/10 - Carrosseries pour véhicules à marchandises caractérisées par l'assemblage entre la carrosserie et le châssis de véhicule comportant des moyens de suspension de la carrosserie sur le châssis
B64D 9/00 - Appareillage pour manutention du fretAppareillage pour faciliter l'embarquement des passagers ou autres
B65D 88/14 - Grands réceptacles rigides spécialement conçus pour le transport par air
17.
METHODS FOR MANUFACTURING METAL OXIDE INFUSED CONFORMAL COATING MATERIAL AND METAL OXIDE INFUSED CONFORMAL COATING MATERIAL MADE USING SAME
A method for manufacturing and applying a metal oxide coating for shielding an object from particle radiation includes heating a quantity of a resin of a polyurethane system and mixing a metal oxide with the quantity of the resin of the polyurethane system to form a mixture. The method further includes mixing a quantity of a hardener of the polyurethane system with the mixture to form a metal oxide infused conformal coating (MOICC). The method further includes applying the MOICC to an object to shield the object from particle radiation and curing the MOICC.
Various examples are provided related to operation of parallel semiconductors with different switching frequencies. In one example, a method of reducing conduction and switching losses in a high current switching circuit includes controlling two hybrid switches to conduct concurrently or alternately, each of the hybrid switches include a wide bandgap device and a silicon power device. Controlling of the silicon power device is at a first gate switching frequency and controlling of the wide bandgap device is at a second gate switching frequency, where the first gate switching frequency is lower than the second gate switching frequency. The silicon power device can be switched at a frequency of about 50 or 60 Hertz. The wide bandgap device can be switched at a frequency greater than 1 kHz.
H03K 17/567 - Circuits caractérisés par l'utilisation d'au moins deux types de dispositifs à semi-conducteurs, p. ex. BIMOS, dispositifs composites tels que IGBT
H03K 17/12 - Modifications pour augmenter le courant commuté maximal admissible
H03K 17/16 - Modifications pour éliminer les tensions ou courants parasites
The present invention relates to tobacco products from plants comprising mutated berberine bridge enzyme-like nucleic acids and the recessive nic1 and/or nic2 alleles and methods of making the same.
A cargo container system, comprising: a vehicle with a cargo compartment; a cargo container configured to fit within the cargo compartment; and, a weight balance adjustment mechanism, comprising at least one of a load sensor and a position sensor, configured to adjust the position of the cargo container within the cargo compartment using data received from the at least one of a load sensor and a position sensor.
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
Educational services, namely, providing career counseling and workforce training for graduate students; educational services, namely providing career placement and preparedness seminars and training for graduate students
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
Educational services, namely, providing career counseling for graduate students; educational services, namely providing career placement and preparedness seminars for graduate students
Methods and systems for rapid detection of volatile organic compounds (VOCs) from plants, such as onions and other fruits and vegetables, are described. The systems include one or more colorimetric sensing elements and a cell-damaging component that can damage one or more cells in a plant sample to induce VOC release. In an exemplary system, a colorimetric dye array is combined with one or more needles on a single sensor body. Use of the system for classifying onion bulbs based on tearing intensity and/or pungency is described.
G01N 21/78 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé en observant l'effet sur un réactif chimique produisant un changement de couleur
G01N 1/22 - Dispositifs pour prélever des échantillons à l'état gazeux
25.
COMPOSITIONS AND METHODS FOR PURIFYING LENTIVIRUS PARTICLES
The present disclosure provides materials and methods related to the purification of viral vectors. In particular, the present disclosure provides peptides, compositions, adsorbents, and related methods, capable of removing process-related impurities (e.g., host cell proteins, nucleic acids, and media components) and product-related impurities (e.g., product fragments, product aggregates, and inactive forms derived from product degradation by or association with other species in the cell culture harvest) from samples during the production and purification of lentivirus particles.
The present disclosure is directed to a multi-variant control system for an industrial facility. In one form of a method, a processor monitors a behavior of a distributed control system with respect to at least a set of uncontrolled variables, a set of controlled variables, and a set of monitored variables; trains a model based on the monitored behavior utilizing at least one of artificial intelligence or machine learning; and identifies, based on the model, a subset of controlled variables for optimization. Further, the processor monitors a behavior of the industrial facility without the use of the distributed control system; optimizes, based on the monitored behavior, the subset of controlled variables to obtain a target result and restrict variation of values of the set of monitored values; and executes a control system for the industrial facility based on the optimization of the subset of controlled variables.
G05B 13/02 - Systèmes de commande adaptatifs, c.-à-d. systèmes se réglant eux-mêmes automatiquement pour obtenir un rendement optimal suivant un critère prédéterminé électriques
27.
SYSTEMS AND METHODS FOR DETERMINING SLEEP PATTERNS AND CIRCADIAN RHYTHMS
Systems and methods for monitoring sleep are disclosed. According to an aspect, a method includes emitting light into tissue. The method also includes detecting light backscattered from the tissue. Further, the method includes determining a sleep pattern based on the backscattered light.
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 5/0205 - Évaluation simultanée de l'état cardio-vasculaire et de l'état d'autres parties du corps, p. ex. de l'état cardiaque et respiratoire
A61B 5/022 - Mesure de la pression dans le cœur ou dans les vaisseaux sanguins par application d'une pression pour fermer les vaisseaux sanguins, p. ex. contre la peauOphtalmodynamomètres
A61B 5/024 - Mesure du pouls ou des pulsations cardiaques
A61B 5/08 - Dispositifs de mesure pour examiner les organes respiratoires
A61B 5/1455 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang en utilisant des capteurs optiques, p. ex. des oxymètres à photométrie spectrale
A61M 21/00 - Autres dispositifs ou méthodes pour amener un changement dans l'état de conscienceDispositifs pour provoquer ou arrêter le sommeil par des moyens mécaniques, optiques ou acoustiques, p. ex. pour mettre en état d'hypnose
28.
BIOSENSOR AND METHODS OF IN-SITU MEASURING OF NUTRIENT CONTENT OF A CROP CULTIVATION SUBSTRATE
The subject matter described herein is directed to systems, detection devices and enzyme sensors for real-time determination of the concentration levels of nutrients in a crop cultivation substrate using thermal signals and change in enthalpy per unit of enzyme. Methods of using the systems, detection devices and enzyme sensors for agricultural applications are described.
C12N 11/14 - Enzymes ou cellules microbiennes immobilisées sur ou dans un support inorganique
C12Q 1/00 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions
C12Q 1/26 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une oxydoréductase
C12Q 1/58 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir l'urée ou une uréase
G01K 7/02 - Mesure de la température basée sur l'utilisation d'éléments électriques ou magnétiques directement sensibles à la chaleur utilisant des éléments thermo-électriques, p. ex. des thermocouples
G01K 7/16 - Mesure de la température basée sur l'utilisation d'éléments électriques ou magnétiques directement sensibles à la chaleur utilisant des éléments résistifs
29.
HYDROFORMYLATION PROCESS FOR PREPARING LINEAR AND BRANCHED ALDEHYDES
Described are processes for preparing linear and branched aldehydes, which comprises reacting an olefin with hydrogen and carbon monoxide in the presence of a catalyst solution comprising rhodium, a hydroformylation solvent, and a fluorophosphite ligand having the general formula (I).
Described are processes for preparing linear and branched aldehydes, which comprises reacting an olefin with hydrogen and carbon monoxide in the presence of a catalyst solution comprising rhodium, a hydroformylation solvent, and a fluorophosphite ligand having the general formula (I).
C07C 45/50 - Préparation de composés comportant des groupes C=O liés uniquement à des atomes de carbone ou d'hydrogènePréparation des chélates de ces composés par réaction avec le monoxyde de carbone par synthèse oxo
B01J 23/46 - Ruthénium, rhodium, osmium ou iridium
The present disclosure provides compositions, methods, and systems related to a dual-affinity ratiometric quenching bioassay. In particular, the present disclosure provides novel compositions and methods that combine selective biorecognition and quenching of fluoescence signals for rapid and sensitive quantification of proteins in complex samples.
G01N 33/542 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec formation d'un complexe immunologique en phase liquide avec inhibition stérique ou modification du signal, p. ex. extinction de fluorescence
G01N 33/569 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour micro-organismes, p. ex. protozoaires, bactéries, virus
G01N 33/58 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des substances marquées
31.
SEQUENCING AND STRATEGIES FOR ENHANCING INTRAVASCULAR THROMBUS DISRUPTION WITH PHASE-CHANGE CAVITATION ENHANCING AGENTS
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (USA)
THE REGENTS OF THE UNIVERSITY OF MICHIGAN (USA)
Inventeur(s)
Dayton, Paul Alexander
Kim, Jinwook
Jiang, Xiaoning
Zhang, Bohua
Wu, Huaiyu
Xu, Zhen
Abrégé
A method for disrupting a blood clot with ultrasound and at least one cavitation enhancing agent includes administering at least one cavitation enhancing agent into a blood vessel of a subject. The method further includes monitoring the at least one cavitation enhancing agent to determine when at least a portion of the at least one cavitation enhancing agent has reached a blood clot. The method further includes controlling application of ultrasound energy to the at least one cavitation enhancing agent within the blood vessel of the subject such that, during a first time period, cavitation-enhancing ultrasound energy is not applied to the at least one cavitation enhancing agent within the blood vessel and, during a second time period after the first time period, cavitation enhancing ultrasound energy is applied to the at least one cavitation enhancing agent within the blood vessel.
A61B 17/22 - Instruments pour comprimer les ulcères ou similaires placés sur les organes internes du corpsInstruments pour curer les cavités des organes du corps, p. ex. des osInstruments, dispositifs ou procédés chirurgicaux pour l'élimination ou la destruction invasives des calculs utilisant des vibrations mécaniquesInstruments, dispositifs ou procédés chirurgicaux pour l'élimination non prévue ailleurs des obstructions dans les vaisseaux sanguins
32.
PROTEIN DEGRADATION SYSTEM, COMPONENTS, AND METHODS
The present disclosure provides components and systems for targeted protein degradation in cells (e.g., in plant cells). In particular, the present disclosure provides a protein containing the Leucine-Rich Repeat (LRR) and novel E3 ligase (NEL) domains of SspH1 for use with Homology Region 1b (HR1b) domain of human PKN1 for degrading target proteins.
In one aspect, the disclosure relates to compositions including a collagen hydrogel and a flavonoid, wherein at least a portion of the collagen hydrogel is crosslinked by the flavonoid, methods of making the cosmetic and pharmaceutical compositions comprising the same, and methods of healing wounds using the same. The disclosed compositions are cytocompatible and can protect cells from oxidative damage through preventing damage from and/or reducing accumulation of reactive oxygen species (ROS). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
Compounds comprising a tetrapyrrole macrocycle that includes a radionuclide; a hydrogelator attached to the tetrapyrrole macrocycle; a water solubilizing group attached to the hydrogelator; and a cleavage site that is between the hydrogelator and the water solubilizing group are described herein along with their methods of use. Two or more compounds of the present invention may two or more compounds may self-assemble (e.g., aggregate), optionally in vivo.
A61K 51/12 - Préparations contenant des substances radioactives utilisées pour la thérapie ou pour l'examen in vivo caractérisées par un aspect physique particulier, p. ex. émulsion, microcapsules, liposomes
35.
ENCAPSULATION OF NUTRITIONAL AND/OR COMPOUNDS FOR CONTROLLED RELEASE AND ENHANCING THEIR BIOAVAILABILITY BY LIMITING CHEMICAL OR MICROBIAL EXPOSURE
A23K 40/30 - Mise en forme ou traitement des produits alimentaires pour animaux par encapsulationMise en forme ou traitement des produits alimentaires pour animaux par revêtement
Described herein are compounds that include a tetrapyrrole macrocycle and a water solubilizing group that is attached to the tetrapyrrole macrocycle along with methods of using the same.
C07D 405/14 - Composés hétérocycliques contenant à la fois un ou plusieurs hétérocycles comportant des atomes d'oxygène comme uniques hétéro-atomes du cycle et un ou plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle contenant au moins trois hétérocycles
C07D 487/22 - Composés hétérocycliques contenant des atomes d'azote comme uniques hétéro-atomes dans le système condensé, non prévus par les groupes dans lesquels le système condensé contient au moins quatre hétérocycles
37.
EFFICIENT RECYCLING OF E-WASTE BY ENERGY LANDSCAPE INVERSION
The present invention provides methods for recovering metals, including rare earth metals, from mixed metals. An example is the recovery of metals from electronic waste. The method of separation is based on the inversion and/or lowering of the thermodynamic energy barrier by using one or more stressors applied at appropriate ratios to create lower energy points in the thermodynamic energy landscape of the mixed metals. Example stressors include a) a chemical stress, b) a mechanical stress, c) a thermal stress, d) and electromagnetic radiation and/or light stress, an interfacial stress, and/or a magnetic flux gradient stress.
A non-shedding hybrid nonwoven web comprised of 99% by mass of functional material(s) co-mingled with the filaments. High level of particle retention within the fabric is provided without the aid of adhesives, binders, adhesive polymers, or post processes. This composite web has a multi-layered structure with a uniform distribution of sorptive particles and desired opposed color contrast on each side. The process includes providing two converging streams of blown polymeric filaments, passive feed of functional material(s) in between the filament streams, and collecting the hybrid webs.
D04H 1/407 - Non-tissés formés uniquement ou principalement de fibres coupées ou autres fibres similaires relativement courtes à partir de voiles ou couches composés de fibres ne possédant pas des propriétés cohésives réelles ou potentielles contenant des substances absorbantes, p. ex. du charbon actif
B01D 39/16 - Autres substances filtrantes autoportantes en substance organique, p. ex. fibres synthétiques
D04H 1/56 - Non-tissés formés uniquement ou principalement de fibres coupées ou autres fibres similaires relativement courtes à partir de voiles ou couches composés de fibres ne possédant pas des propriétés cohésives réelles ou potentielles par soudage des fibres ensembles, p. ex. par fusion partielle ou dissolution en association avec la formation de la fibre, p. ex. suivant immédiatement l'extrusion des fibres en brin
D04H 3/16 - Non-tissés formés uniquement ou principalement de fils ou de matériaux filamenteux similaires de bonne longueur caractérisés par la méthode de renforcement ou de consolidation avec liages produits par soudage entre fils thermoplastiques ou filaments avec liages entre filaments thermoplastiques produits en relation avec la formation des filaments, p. ex. suivant immédiatement l'extrusion
Methods of mineralizing hemp fiber to provide hemp fibers mineralized with calcium carbonate are described. Also described are mineralized hemp fibers and compositions including the mineralized hemp fibers. The mineralized hemp fibers can be hemp fibers with calcium carbonated deposited on the hemp fiber surface. The compositions including the mineralized hemp fibers can be cementitious or non-cementitious. Also described are methods of preparing “green” concrete comprising mineralized hemp.
The present disclosure provides compositions and methods related to tobacco plants. In particular, the present disclosure provides novel methods for producing tobacco plants, and any related tobacco products, having low nicotinic alkaloid content. Tobacco plants produced according to the methods of the present disclosure exhibit reduced levels of nicotinic alkaloids (e.g., nicotine) compared to both naturally-occurring and transgenic tobacco plants, and thus represent a commercially valuable alternative to currently available tobacco varieties.
A01H 5/00 - Angiospermes, c.-à-d. plantes à fleurs, caractérisées par leurs parties végétalesAngiospermes caractérisées autrement que par leur taxonomie botanique
A01H 6/00 - Angiospermes, c.-à-d. plantes à fleurs, caractérisées par leur taxonomie botanique
43.
MODIFIED ALGINATES AND METHODS OF MAKING AND USING THEREOF
The loss of cross-linking abilities in highly substituted alginate scaffolds is a significant problem affecting the use of alginate polymers in implants, cell delivery, and tissue engineering. Disclosed are modified alginate scaffolds that retain their gelation properties under high chemical modification, as well as methods of making and using thereof.
An exemplary left ventricular assist device (LVAD) and method that employs design and material designs to reduce the thrombosis risk of LVAD implant in a patient. One feature of the design includes a stented inlet member for the device that can reduce or fully eliminate a flow stasis that can trigger blood protein adsorption that can lead to chain reactions that then result in thrombosis. Other features of the design include (i) a flexible rotor and/or pump housing that can reduce blood damage, (ii) hydrophilic slippery coatings at high sheer components, such as the rotor to further reduce protein adsorption and thus thrombosis risk, (iii) magnetic-based drive and bearing components that can improve the hemocompatibility of the blood pump, and (iv) advanced controls and charging.
A61M 60/178 - Pompes ou dispositifs de pompage implantables, c.-à-d. que le sang est pompé à l’intérieur du corps du patient implantables dans ou sur le cœur, ou autour du cœur prélevant le sang d’un ventricule et renvoyant le sang vers le système artériel par une canule externe au ventricule, p. ex. dispositifs d’assistance pour ventricule gauche ou droit
A61M 60/216 - Pompes pour le sang à déplacement non positif comportant un élément rotatif agissant sur le sang, p. ex. un impulseur
A61M 60/861 - Connexions ou ancrages pour connecter ou ancrer les pompes ou dispositifs de pompage à des parties du corps du patient
45.
DISCOVERY OF DOUBLE HELIX AND IMPACT ON NANOSCALE TO MESOSCALE CRYSTALLINE STRUCTURES
Screw dislocations play a significant role in the growth of crystalline structures by providing a continuous source of surface steps, which represent available sites for crystal growth. Here we show that pure screw dislocations can become helical by the absorption of defects (e.g., vacancies), and develop attractive interaction with another helical dislocation to form a double helix of screw dislocations. These single and double helix of screw dislocations can result in the formation of interesting nanostructures with large Eshelby twists. Examples of the formation of a double helix during thermal annealing of screw dislocations in magnesium oxide are presented. These large effective Burgers also unravel the mechanism for the formation of nanopipes and micropipes with hollow cores and nanotubes with Eshelby twists in technologically important materials, such as SiC, GaN and ZnO that are utilized in a variety of advanced solid state devices.
This invention relates to methods for increasing phage resistance in Clostridium species through incorporation of novel recombinant Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) RNAs using endogenous CRISPR systems and/or recombinant nucleic acid constructs encoding clostridia Type I-B and Type I-C CASCADE complexes, and/or expression cassettes and vectors comprising the same.
In one aspect, the disclosure relates to catalytic phase transfer sorbents (PTS) for producing hydrogen-enriched syngas from a carbonaceous feedstock, the PTS comprising a formula selected from ABO3 and An+1BnO3n+1, wherein A comprises one or more alkali metals or alkaline earth metals, wherein B comprises one or more transition metals, and wherein X comprises an anion. Also disclosed is a system for hydrogen generation from carbonaceous feedstocks, the system comprising a gasifier unit for production of H2-rich syngas and a regenerator unit for regeneration of spent PTS. Further disclosed herein is a method for hydrogen generation from carbonaceous feedstocks using the disclosed systems. The disclosed systems can be operated isothermally through 10 or more cycles without degradation in performance, while the disclosed methods can yield 50% or more H2 relative to carbon-containing species. In some aspects, the methods produce little to no CO2.
B01J 8/26 - Procédés chimiques ou physiques en général, conduits en présence de fluides et de particules solidesAppareillage pour de tels procédés les particules étant fluidisées selon la technique du "lit fluidisé" comportant au moins deux lits fluidisés, p. ex. installations de réaction et de régénération
B01J 8/18 - Procédés chimiques ou physiques en général, conduits en présence de fluides et de particules solidesAppareillage pour de tels procédés les particules étant fluidisées
B01J 20/06 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtrationAbsorbants ou adsorbants pour la chromatographieProcédés pour leur préparation, régénération ou réactivation contenant une substance inorganique contenant des oxydes ou des hydroxydes des métaux non prévus dans le groupe
B01J 20/28 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtrationAbsorbants ou adsorbants pour la chromatographieProcédés pour leur préparation, régénération ou réactivation caractérisées par leur forme ou leurs propriétés physiques
B01J 23/92 - Régénération ou réactivation de catalyseurs contenant des métaux, oxydes ou hydroxydes prévus dans les groupes
B01J 35/40 - Catalyseurs caractérisés par leur forme ou leurs propriétés physiques, en général caractérisés par leurs dimensions, p. ex. granulométrie
B01J 38/30 - Traitement avec un gaz contenant de l'oxygène libre en suspension gazeuse, p. ex. lits fluidisés
C01B 3/44 - Production d'hydrogène ou de mélanges gazeux contenant de l'hydrogène par réaction de composés organiques gazeux ou liquides avec des agents gazéifiants, p. ex. de l'eau, du gaz carbonique, de l'air par réaction d'hydrocarbures avec des agents gazéifiants avec des catalyseurs avec des particules solides mobiles utilisant la technique du lit fluidisé
The disclosure relates to nonwoven fabric including a nonwoven material having a first surface and an opposing second surface, wherein the first surface has a first average surface charge and the second surface has a second average surface charge, the first average surface charge being different from the second average surface charge, wherein the nonwoven material includes a first plurality of fibers including a first polymer and a second plurality of fibers including a second polymer different from the first polymer. A method for imparting surface charge to a nonwoven N61824_1570Wabric is also provided.
D04H 1/492 - Non-tissés formés uniquement ou principalement de fibres coupées ou autres fibres similaires relativement courtes à partir de voiles ou couches composés de fibres ne possédant pas des propriétés cohésives réelles ou potentielles les voiles ou couches étant renforcées par des moyens mécaniques, p. ex. par roulage par aiguilletage ou opérations similaires pour provoquer l'enchevêtrement des fibres par jet de fluide
D04H 1/56 - Non-tissés formés uniquement ou principalement de fibres coupées ou autres fibres similaires relativement courtes à partir de voiles ou couches composés de fibres ne possédant pas des propriétés cohésives réelles ou potentielles par soudage des fibres ensembles, p. ex. par fusion partielle ou dissolution en association avec la formation de la fibre, p. ex. suivant immédiatement l'extrusion des fibres en brin
D04H 3/11 - Non-tissés formés uniquement ou principalement de fils ou de matériaux filamenteux similaires de bonne longueur caractérisés par la méthode de renforcement ou de consolidation avec liages faits mécaniquement entre fils et filaments par jet de fluide
D04H 3/16 - Non-tissés formés uniquement ou principalement de fils ou de matériaux filamenteux similaires de bonne longueur caractérisés par la méthode de renforcement ou de consolidation avec liages produits par soudage entre fils thermoplastiques ou filaments avec liages entre filaments thermoplastiques produits en relation avec la formation des filaments, p. ex. suivant immédiatement l'extrusion
49.
BIOORTHOGONAL CATALYTIC PATCH AND METHODS OF USING THE SAME
A bioorthogonal catalytic patch integrates TiO2 nanosheets populated with metallic nanoparticles into polyvinyl alcohol-based microneedles arranged in an array. This bioorthogonal patch-based device is robust, removable and can effectively mediate the conversion of caged substrates into their active states once placed at the site of application. The capacity of the patch in executing bioorthogonal catalysis in high-level living systems was demonstrated by localized dealkylation of a caged doxorubicin prodrug at the melanoma tumor site and restoration of its pharmacological properties for cancer therapy. This in situ applied patch facilitated to enhance the local treatment efficacy and eliminate off-targeted prodrug activation or dose-dependent side effect towards healthy organs or tissues located away from the application site.
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 31/704 - Composés ayant des radicaux saccharide liés à des composés non-saccharide par des liaisons glycosidiques liés à un composé carbocyclique, p. ex. phloridzine liés à un système carbocyclique condensé, p. ex. sennosides, thiocolchicosides, escine, daunorubicine, digitoxine
A61K 47/32 - Composés macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. carbomères
A61M 37/00 - Autres appareils pour introduire des agents dans le corpsPercutanisation, c.-à-d. introduction de médicaments dans le corps par diffusion à travers la peau
50.
COMPOSITIONS AND METHODS FOR PURIFYING VIRAL VECTORS
The present disclosure provides materials and methods related to the purification of viral vectors. In particular, the present disclosure provides compositions, and related methods, comprising peptide ligands capable of removing process-related impurities (e.g., host cell proteins, nucleic acids, and media components) and product-related impurities (e.g., product fragments, product aggregates, and inactive forms derived from product degradation by or association with other species in the cell culture harvest) from biological fluids during the production and purification of adeno-associated viruses (AAVs).
Disclosed herein are thrombin-sensitive platelet like particles. The particles can be used to promote healing in a variety of wounds and can be used in drug delivery systems.
A61L 26/00 - Aspects chimiques des bandages liquides ou utilisation de matériaux pour les bandages liquides
A61P 17/02 - Médicaments pour le traitement des troubles dermatologiques pour traiter les blessures, les ulcères, les brûlures, les cicatrices, les cheloïdes, ou similaires
C07K 7/06 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 5 à 11 amino-acides
A61K 47/69 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament le conjugué étant caractérisé par sa forme physique ou sa forme galénique, p. ex. émulsion, particule, complexe d’inclusion, stent ou kit
C08L 33/26 - Homopolymères ou copolymères de l'acrylamide ou de la méthacrylamide
University of Pittsburgh - Of the Commonwealth System of Higher Education (USA)
North Carolina State University (USA)
Blatek Industries, Inc. (USA)
Inventeur(s)
Kang, Kim
Chen, Qiyang
Sheng, Zhiyu
Zhang, Bohua
Kim, Howuk
Wu, Huaiyu
Jiang, Xiaoning
Chen, Mengyue
Geng, Xuecang
Abrégé
Ultrasound systems and methods of use are provided for rapidly heating a target area of a subject. The ultrasound system can include at least one imaging transducer array for imaging the target area, and at least two spaced-apart heating transducer arrays for heating the target area. The heating transducer arrays can be separated by the imaging transducer array on an ultrasound probe.
This invention is directed to recombinant Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and recombinant nucleic acid constructs encoding clostridia Type I-B CASCADE complexes, expression cassettes and vectors comprising the same, and methods of use thereof for modifying genomes, altering expression, killing one or more cells in a population of cells, and screening or selecting for genomic variants of an organism.
‘XZ 14069’ is a medium to dark green perennial zoysiagrass cultivar with medium-fine texture low incidence of large patch disease and aggressive stoloniferous growth producing high density turf performance ideal for low-management landscaping. It is distinguishable from other cultivars by medium-fine texture, plant architecture and characteristics such as high drought tolerance, turf quality, disease resistance and aggressive establishment from minimal input. ‘XZ 14069’ shows persistence under an array of climates including warm-temperate, warm-humid and hot-arid. ‘XZ 14069’ is also genetically distinct from other zoysiagrass cultivars currently in the marketplace known to the Inventor. ‘XZ 14069’ exhibits very low fertility and no inflorescences have been observed.
Various examples are provided related to monitoring of various biomarkers in wound fluid to indicate a wound status. In one example, a wound sensing system includes a platform for examining a wound; and an array of sensors disposed on the platform. The array of sensors can include one or more fluorometric assay sensor, one or more colorimetric assay sensor, or both. Each of the fluorometric assay sensor can produce a fluorescence intensity proportional to a corresponding target concentration and each of the colorimetric sensor can produce a color change proportional to a corresponding target concentration. In another example, a method includes swiping a wound with an array of sensors of a wound sensing system; waiting for a predetermined amount of time; capturing an image of the of the array of sensors; and analyzing the image to determine one or more analyte concentration based upon fluorescence intensity, color intensity or both.
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 5/103 - Dispositifs de mesure pour le contrôle de la forme, du dessin, de la dimension ou du mouvement du corps ou de parties de celui-ci, à des fins de diagnostic
‘NCORNSP-031SHMG’ is a moderately compact and loosely upright variety with a moderate growth rate and is well branched. It is distinguishable from other ornamental sweetpotato cultivars by its dark red heart shaped leaves, a moderately-compact habit and semi-erect mounding plant architecture. The dark red leaves, uniform color, short internodes, and the plant architecture, which promotes good plant production in the greenhouse for wholesale distributors, distinguishes ‘NCORNSP-031SHMG’ amongst the current ornamental sweetpotatoes in the marketplace. In greenhouse and field trials, ‘NCORNSP-031SHMG’ is shown to be suitable for use as a landscape or containerized plant.
‘NCORNSP-032SCRHI’ is a moderately compact and loosely upright variety with a moderate growth rate and is well branched. It is distinguishable from other ornamental sweetpotato cultivars by its red to burgundy five lobed leaves, a moderately-compact habit and semi-erect mounding plant architecture. The burgundy leaves, uniform color, short internodes, and the plant architecture, which promotes good plant production in the greenhouse for wholesale distributors, distinguishes ‘NCORNSP-032SCRHI’ amongst the current ornamental sweetpotatoes in the marketplace. In greenhouse and field trials, ‘NCORNSP-032SCRHI’ is shown to be suitable for use as a landscape or containerized plant. The production of flowers by ‘NCORNSP-032SCRHI’ is not observed under short-day conditions.
An exemplary method for producing a strain sensor using crack propagation includes opening and blunting includes applying conductive nanowires to a substrate to form a conductive nanowire network on the substrate. The method also includes applying an elastomer to the nanowire network to form a composite layer on top of the conductive nanowire network. The method also includes removing the substrate from the conductive nanowire network, wherein removing the substrate at least partially exposes a surface of the conductive nanowire network. The method further includes cutting intervallic incisions in the surface of the conductive nanowire network, wherein the intervallic incisions extend alternatingly and inwardly from one of two opposing edges of the conductive nanowire network.
G01B 7/16 - Dispositions pour la mesure caractérisées par l'utilisation de techniques électriques ou magnétiques pour mesurer les déformations dans un solide, p. ex. au moyen d'une jauge de contrainte à résistance
Various examples are provided related to Q-silicon, Q-carbon and combinations thereof, and synthesis, properties and applications of Q-silicon and Q-carbon. In one example, a method includes forming a layer of amorphous silicon; melting at least a portion of the layer of amorphous silicon in an undercooled state; and forming Q-silicon by quenching the melted amorphous silicon from the undercooled state. In another example, a Q-silicon includes a random arrangement of tetrahedra, the tetrahedra including dangling bonds, unpaired spins or both. The atomic structure of the Q-silicon is based upon time in an undercooled state before quenching. In another example, a battery anode includes Q-silicon mixed with a polyvinylidene difluoride (PVDF) binder, the Q-silicon including a random arrangement of tetrahedra, the tetrahedra comprising dangling bonds, unpaired spins or both. The battery anode can include Q-carbon and Q-silicon mixed with the PVDF binder.
The present invention provides wearable plant sensors for continuous monitoring of plant physiology by tracking both biochemical and biophysical signals of the plant and its microenvironment. Sensors for detecting volatile organic compounds (VOC), temperature, and humidity are integrated into a single platform. The abaxial leaf attachment position is selected based on the stomata density to improve the sensor signal strength. This versatile platform enables various stress monitoring applications, ranging from tracking plant water loss to early detection of plant pathogens. A machine learning model was also developed to analyze multichannel sensor data for quantitative detection of tomato spotted wilt virus (TSWV) as early as four days after inoculation.
A01H 5/00 - Angiospermes, c.-à-d. plantes à fleurs, caractérisées par leurs parties végétalesAngiospermes caractérisées autrement que par leur taxonomie botanique
A01H 6/00 - Angiospermes, c.-à-d. plantes à fleurs, caractérisées par leur taxonomie botanique
Sustainable paper-based packaging materials, e.g., paper-based food packaging materials, are described. The packaging materials are based on paper formed from fiber derived from waste biomass, such as hemp hurds, mixes containing hemp hurds and hemp bast fibers, bagasse, and cocoa pod husks. Also described are methods of making the packaging materials. The methods can include environmentally friendly pulping and/or bleaching processes.
D21H 11/12 - Pâte obtenue à partir de végétaux ou de récoltes non ligneux, p. ex. coton, lin, paille ou bagasse
D21C 3/02 - Réduction en pâte des matières contenant de la cellulose avec des bases inorganiques ou des composés à réaction alcaline, p. ex. procédés au sulfate
D21C 9/14 - Blanchiment avec des halogènes ou des composés contenant des halogènes avec ClO2 ou des chlorites
D21F 11/02 - Procédés de fabrication de longueurs continues de papier ou de carton, ou de nappe humide pour la production de panneaux de fibres, sur des machines à papier du type Fourdrinier
D21H 17/00 - Matériaux non fibreux ajoutés à la pâte caractérisés par leur constitutionMatériaux d'imprégnation du papier caractérisés par leur constitution
D21H 17/15 - Acides polycarboxyliques, p. ex. acide maléique
A voice therapy device including a body having an internal passageway with a longitudinal axis that defines an airflow direction; a mouthpiece positioned at a proximal end of the body; and a resistance portion positioned at a distal end of the body, where the resistance portion is adjustable to vary an airflow resistance through the internal passageway. In some embodiments, the voice therapy device includes a sensor electrically coupled to a processor. A system for voice therapy includes the voice therapy device and a software application.
A transparent structure (40) for emitting light is described. The transparent structure comprises an emissive layer (EML) (44) positioned between first (46) and second (42) electrodes. The EML (44) is tuned such that luminance through the first electrode (46) is greater than luminance through the second electrode (42).
A transparent structure for emitting light is described. The transparent structure comprises an emissive layer (EML) positioned between first and second electrodes. The EML is tuned such that luminance through the first electrode is greater than luminance through the second electrode.
H10K 50/17 - Couches d'injection des porteurs de charge
H10K 50/816 - Multicouches, p. ex. multicouches transparentes
H10K 71/16 - Dépôt d'une matière active organique en utilisant un dépôt physique en phase vapeur [PVD], p. ex. un dépôt sous vide ou une pulvérisation cathodique
H10K 71/60 - Formation de régions ou de couches conductrices, p. ex. d’électrodes
H01L 29/66 - Types de dispositifs semi-conducteurs
H01L 21/18 - Fabrication ou traitement des dispositifs à semi-conducteurs ou de leurs parties constitutives les dispositifs ayant des barrières de potentiel, p. ex. une jonction PN, une région d'appauvrissement ou une région de concentration de porteurs de charges les dispositifs ayant des corps semi-conducteurs comprenant des éléments du groupe IV du tableau périodique, ou des composés AIIIBV, avec ou sans impuretés, p. ex. des matériaux de dopage
H01L 29/20 - Corps semi-conducteurs caractérisés par les matériaux dont ils sont constitués comprenant, à part les matériaux de dopage ou autres impuretés, uniquement des composés AIIIBV
H01L 29/205 - Corps semi-conducteurs caractérisés par les matériaux dont ils sont constitués comprenant, à part les matériaux de dopage ou autres impuretés, uniquement des composés AIIIBV comprenant plusieurs composés dans différentes régions semi-conductrices
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (USA)
Inventeur(s)
Gilger, Brian
Crabtree, Elizabeth
Hirsch, Matthew L.
Abrégé
The present disclosure provides compositions and methods related to the treatment of ocular diseases in equines. In particular, the present disclosure provides novel compositions and methods related to the administration of therapeutic compositions comprising AAV-equine IL-10 for the treatment and/or prevention of various ocular diseases (e.g., non-infectious uveitis).
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
The present disclosure provides compositions, methods, and kits related to DNA transformation in bacteria. In particular, the present disclosure provides novel compositions and methods for enhancing DNA transformation by replicating a DNA methylation pattern used in a bacterial host strain. The compositions, methods, and systems described herein utilize cell-free transcription-translation mixtures and DNA methylation complexes to increase transformation efficiency and efficacy for any bacterial host.
The present disclosure relates generally to test devices comprising a round window membrane and/or an oval window membrane separating two compartments and to the use of such devices in methods for identifying compounds and compositions suitable for use as therapeutics via intratympanic administration.
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
C12M 1/12 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens de stérilisation, filtration ou dialyse
C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies
C12M 3/00 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus
72.
COMPOSITIONS AND METHODS RELATED TO NUCLEIC ACID ANTICOAGULANTS AND ANTIDOTES
The present disclosure provides compositions and methods related to nucleic acid molecules having therapeutic activity. In particular, the present disclosure provides nucleic acid molecules comprising one or more aptamers having anticoagulant activity, as well as corresponding antidote nucleic acid molecules capable of modulating anticoagulant activity.
In one aspect, the disclosure relates to a method for removing a hyperpolarization catalyst from a solution comprising a hyperpolarized molecule, the method including at least the step of filtering the solution using a silica-based sorbent such as a normal phase, reverse phase, or ion exchange silica-based sorbent. In an aspect, the hyperpolarization catalyst includes a metal center such as Ir, Rh, Co, Fe, Ru, Pd, or Ni. In any of these aspects, the hyperpolarized molecule includes at least one hyperpolarized nucleus selected from 1H, 15N, 13C, or a combination thereof, wherein the nucleus has been hyperpolarized using signal amplification by reversible exchange. In another aspect, the filtration step separates the hyperpolarization catalyst from the hyperpolarized molecule based on at least one differing property. Also disclosed are biocompatible contrast agents containing the hyperpolarized molecules and methods of imaging using the same.
B01J 20/10 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtrationAbsorbants ou adsorbants pour la chromatographieProcédés pour leur préparation, régénération ou réactivation contenant une substance inorganique contenant de la silice ou un silicate
B01D 53/14 - Séparation de gaz ou de vapeursRécupération de vapeurs de solvants volatils dans les gazÉpuration chimique ou biologique des gaz résiduaires, p. ex. gaz d'échappement des moteurs à combustion, fumées, vapeurs, gaz de combustion ou aérosols par absorption
B01J 8/00 - Procédés chimiques ou physiques en général, conduits en présence de fluides et de particules solidesAppareillage pour de tels procédés
74.
MAGNETIC FIELD CONTROL OF SABRE HYPERPOLARIZED MOLECULES FOR PROCESSING AND ADMINISTRATION
In one aspect, the disclosure relates to a method for conserving hyperpolarization in a hyperpolarized molecule undergoing at least one processing step, the method including conducting the at least one processing step in a magnetic field having a magnetic field strength higher than the magnetic field strength of Earth. In an aspect, prior to the at least one processing step but following hyperpolarization, the molecule can be transferred into a processing magnetic field in an adiabatic manner. In still another aspect, following the processing step, the molecule can be transferred into a signal detection magnetic field in an adiabatic manner. Prior to performing the method, the hyperpolarized molecule can be produced using signal amplification by reversible exchange (SABRE). Also disclosed herein are hyperpolarized molecules prepared by the disclosed methods, contrast agents comprising the same, and methods for diagnosing a disease or monitoring the progress of disease treatment using the same.
A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiquesMesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p. ex. formation d'images par résonance magnétique
G01R 33/28 - Détails des appareils prévus dans les groupes
G01R 33/56 - Amélioration ou correction de l'image, p. ex. par des techniques de soustraction ou d'établissement de moyenne
75.
OXIDE-MOLTEN SALT COMPOSITES FOR HIGH-PERFORMANCE THERMAL ENERGY STORAGE
In one aspect, the disclosure relates to an oxide-molten salt (OMS) composite material offering excellent energy storage capacity at low cost. The OMS composite material can be provided in at least three forms, including a porous, perovskite-oxide particle as a matrix having pores filled with unary salt or salt mixtures; an external shell of perovskite-oxide particles and an internal core of salt or a salt mixture; and/or a porous, perovskite-oxide particle as a matrix filled with unary salt or salt mixtures, wherein the whole particle is enclosed with an oxide outer shell. Further in this aspect, the outer shell can be dense but either mixed ionic-electronically conductive or porous. In another aspect, the disclosed methods and systems can be used for grid-scale energy storage by retrofitting existing steam turbine-based power plants and concentrated solar plants. In a further aspect, the disclosed methods, systems, and materials are environmentally benign.
F28D 20/00 - Appareils ou ensembles fonctionnels d'accumulation de chaleur en généralAppareils échangeurs de chaleur de régénération non couverts par les groupes ou
Suspensions include an aqueous medium and a plurality of particles. The particles include polymeric carrier material dispersed throughout the particle and active ingredient dispersed throughout the particle. The polymeric carrier material can be biodegradable, and one example is a cellulose ester. Exemplary active ingredients include an insecticide, a fungicide, and a pesticide. In some instances, the plurality of particles have an average diameter of 25 nm to 5 μm. Exemplary suspensions may be applied to plant surfaces.
A01N 43/40 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés hétérocycliques comportant des cycles avec un atome d'azote comme unique hétéro-atome du cycle des cycles à six chaînons
Exemplary catalysts may comprise a two-dimensional substrate and at least one organometallic compound bonded to the two-dimensional substrate. The at least one organometallic compound may comprise a carbonyl group. Exemplary methods of preparing a polymer product may comprise combining a catalyst with an alcohol and an ester in a solvent, thereby generating a mixture, and obtaining the polymer product from the mixture.
B01J 31/12 - Catalyseurs contenant des hydrures, des complexes de coordination ou des composés organiques contenant des composés organiques ou des hydrures métalliques contenant des composés organométalliques ou des hydrures métalliques
Various examples are provided related to resonance tracking broadband energy harvesting. In one example, a resonance tracking energy harvester includes a pendulum adaptive frequency oscillator including an adjustable pendulum rod and control circuitry that can adjust a length of the adjustable pendulum rod in response to a sensed forcing frequency. In another example, a method of resonance tracking energy harvesting, includes sensing a forcing frequency applied to a pendulum adaptive frequency oscillator comprising an adjustable pendulum rod; and adjusting a length of the adjustable pendulum rod in response to the sensed forcing frequency. Oscillation and/or vibration of the pendulum adaptive frequency oscillator can be converted.
H02N 2/18 - Machines électriques en général utilisant l'effet piézo-électrique, l'électrostriction ou la magnétostriction fournissant une sortie électrique à partir d'une entrée mécanique, p. ex. générateurs
G05D 3/12 - Commande de la position ou de la direction utilisant la contre-réaction
79.
COMPOSITIONS AND METHODS FOR TREATING PAIN IN ANIMALS
The present disclosure provides compositions and methods related to the treatment and/or reduction of pain in an animal. In particular, the present disclosure provides novel compositions and methods for treating and/or reducing pain in an animal (e.g., a pig) by administering an analgesic intranasally. The composition and methods described herein provide a more convenient and effective means for treating and/or reducing pain in an animal (e.g., pain associated with industrial processing) in a manner that also improves the animal's health and welfare.
A61K 31/44 - Pyridines non condenséesLeurs dérivés hydrogénés
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]
80.
NONWOVEN MATERIAL ADAPTED FOR HIGH EFFICIENCY AIR FILTRATION
The present disclosure provides a nonwoven material including a blend of a first plurality of monocomponent fibers and a second plurality of segmented fibers having segments of a first polymer and segments of a second polymer different from the first polymer, wherein the nonwoven material includes about 75 to about 95% by weight of the monocomponent fibers, and about 5 to about 25% by weight of the segmented fibers, based on the total weight of the nonwoven material, and wherein the segmented fibers are at least partially fibrillated or split. An air filter including the nonwoven material is also provided.
B01D 29/03 - Filtres à éléments filtrants stationnaires pendant la filtration, p. ex. filtres à aspiration ou à pression, non couverts par les groupes Leurs éléments filtrants avec des éléments filtrants plats autoportants
D01F 6/06 - Filaments, ou similaires, faits par l’homme, à un seul composant, formés de polymères synthétiquesLeur fabrication à partir d'homopolymères obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone à partir des polyoléfines à partir de polypropylène
D01F 8/14 - Filaments, ou similaires, faits par l’homme, conjugués, c.-à-d. à plusieurs composantsLeur fabrication à partir de polymères synthétiques avec au moins un polyester comme constituant
81.
POPULATION GENETICS APPROACH TO BIOLOGICAL CONTROL OF MYCOTOXIN PRODUCTION
The invention relates to methods for controlling mycotoxin production in field populations of heterothallic and homothallic filamentous fungi through application of biocontrol compositions comprising selected strains of the heterothallic and homothallic filamentous fungi, the selected strains having a lineage of low mycotoxin production or no mycotoxin production and having opposite mating types (heterothallic) or both mating types (homothallic) (e.g., MAT1-1, MAT1-2).
A device can automatically count, speciate, and determine infectivity of eggs of parasites in food animals. The device can include a chamber that can receive a sample specimen. Additionally, the device can include a light source. The light source can illuminate a field of view of the sample specimen in the chamber. The device can further include a microscope objective to magnify the field of view of the sample specimen. The device can include a camera. The camera can image the field of view of the sample specimen. The camera can further produce an on-site dataset of images. Additionally, the camera can provide the on-site dataset of images to a trained machine-learning model for analysis of at least one species of parasites.
C12Q 1/04 - Détermination de la présence ou du type de micro-organismeEmploi de milieux sélectifs pour tester des antibiotiques ou des bactéricidesCompositions à cet effet contenant un indicateur chimique
G16H 10/40 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données relatives aux analyses de laboratoire, p. ex. pour des analyses d’échantillon de patient
G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p. ex. l’édition
The present disclosure provides compositions and methods related to aptamer-based sensors. In particular, the present disclosure provides aptamer-based sensors, and related detection assays, that are capable of binding fentanyl (and derivatives and analogs thereof) at nanomolar concentrations in biological samples in a manner that is rapid and specific.
C12N 15/115 - Aptamères, c.-à-d. acides nucléiques liant spécifiquement une molécule cible avec une haute affinité sans s'y hybrider
G01N 33/94 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des narcotiques
C12Q 1/6811 - Méthodes de sélection pour la production ou l’élaboration d’oligonucléotides spécifiques cibles ou de molécules de liaison
84.
CONTACTLESS SOIL MOISTURE ESTIMATION USING RADIOFREQUENCY SIGNALS
A system for estimating moisture in soil includes a first antenna for transmitting RF signals, second antennas for receiving RF signals, and a controller configured to: emit, via the first antenna, RF signals at a plurality of frequency increments; determine a channel frequency response (CFR) based on amplitude attenuation and phase change of reflected RF signals detected by the second antennas; determine a power delay profile (PDP) for the second antennas based on the CFRs; extract a subset of the reflected RF signals using peak detection on the PDPs; and for each layer of the soil and for each of the subset of reflected RF signals, determine: i) a wavelength of the reflected RF signal in the layer, ii) an estimated depth of the layer, iii) a dielectric permittivity of the layer based on the wavelength, and iv) an estimated moisture content of the layer based on the dielectric permittivity.
Various examples are provided related to photovoltaic systems that utilize multiple current source inverters. In one example, a solar inverter system includes DC-DC current source converters coupled to a DC link and a grid-frequency inverter coupled to the DC link. The DC power can be converted from energy obtained from a photovoltaic (PV) panel coupled to the DC-DC current source converters and the grid-frequency inverter can generate AC power from the DC power provided to the DC link.
H02M 7/515 - Transformation d'une puissance d'entrée en courant continu en une puissance de sortie en courant alternatif sans possibilité de réversibilité par convertisseurs statiques utilisant des tubes à décharge avec électrode de commande ou des dispositifs à semi-conducteurs avec électrode de commande utilisant des dispositifs du type thyratron ou thyristor exigeant des moyens d'extinction utilisant uniquement des dispositifs à semi-conducteurs
H02J 3/38 - Dispositions pour l’alimentation en parallèle d’un seul réseau, par plusieurs générateurs, convertisseurs ou transformateurs
H02M 3/158 - Transformation d'une puissance d'entrée en courant continu en une puissance de sortie en courant continu sans transformation intermédiaire en courant alternatif par convertisseurs statiques utilisant des tubes à décharge avec électrode de commande ou des dispositifs à semi-conducteurs avec électrode de commande utilisant des dispositifs du type triode ou transistor exigeant l'application continue d'un signal de commande utilisant uniquement des dispositifs à semi-conducteurs avec commande automatique de la tension ou du courant de sortie, p. ex. régulateurs à commutation comprenant plusieurs dispositifs à semi-conducteurs comme dispositifs de commande finale pour une charge unique
H02M 7/537 - Transformation d'une puissance d'entrée en courant continu en une puissance de sortie en courant alternatif sans possibilité de réversibilité par convertisseurs statiques utilisant des tubes à décharge avec électrode de commande ou des dispositifs à semi-conducteurs avec électrode de commande utilisant des dispositifs du type triode ou transistor exigeant l'application continue d'un signal de commande utilisant uniquement des dispositifs à semi-conducteurs, p. ex. onduleurs à impulsions à un seul commutateur
86.
PORTABLE DEVICE FOR ENUMERATION AND SPECIATION OF FOOD ANIMAL PARASITES
A device can automatically count, speciate, and determine infectivity of eggs of parasites in food animals. The device can include a chamber that can receive a sample specimen. Additionally, the device can include a light source. The light source can illuminate a field of view of the sample specimen in the chamber. The device can further include a microscope objective to magnify the field of view of the sample specimen. The device can include a camera. The camera can image the field of view of the sample specimen. The camera can further produce an on-site dataset of images. Additionally, the camera can provide the on-site dataset of images to a trained machine-learning model for analysis of at least one species of parasites.
Provided are expression cassettes that can be used to express proteins in plants. In some embodiments, the expression cassettes include polynucleotides that encode polypeptides that are at least 96% identical to SEQ ID NO: 2 operably linked to a promoter and a transcription terminator and optionally a tag sequence. Also provided are recombinant vectors, cells, and transgenic plants, progeny, and seeds that include the presently disclosed expression cassettes, and methods for using the disclosed expression cassettes to alter geminivirus resistance and suppress virus-induced leaf chlorosis, leaf curling, or both in plants.
An implantable device is provided that includes a tubular body with at least one open end, defining an inner space, a cap closing the at least one open end and having an inner surface on one side and an outer surface on the other side, the inner surface facing the inner space, and a circuit board being placed in the inner space, having an active surface, a board electrode disposed on the active surface, and a wireless communication circuit to communicate outside of a body, biological information obtained via the board electrode. Moreover, a recess and an inner electrode are disposed on the inner surface of the cap, and the circuit board is disposed in the recess, and the inner electrode is electrically connected to the board electrode. An outer electrode is disposed on the outer surface of the cap and is electrically connected to the inner electrode.
A61B 5/29 - Électrodes bioélectriques à cet effet spécialement adaptées à des utilisations particulières pour l’électrocardiographie [ECG] invasives pour implantation permanente ou à long terme
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 5/024 - Mesure du pouls ou des pulsations cardiaques
89.
COMPOSITIONS AND METHODS FOR PURIFYING VIRAL VECTORS
The present disclosure provides materials and methods related to the purification of viral vectors. In particular, the present disclosure provides compositions, and related methods, comprising peptide ligands capable of removing process-related impurities (e.g., host cell proteins, nucleic acids, and media components) and product-related impurities (e.g., product fragments, product aggregates, and inactive forms derived from product degradation by or association with other species in the cell culture harvest) from biological fluids during the production and purification of adeno-associated viruses (AAVs).
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
C12N 7/00 - Virus, p. ex. bactériophagesCompositions les contenantLeur préparation ou purification
e.g.e.g.e.g., product fragments, product aggregates, and inactive forms derived from product degradation by or association with other species in the cell culture harvest) from biological fluids during the production of a biologic.
C07K 7/06 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 5 à 11 amino-acides
C07K 1/22 - Chromatographie d'affinité ou techniques analogues basées sur des procédés d'absorption sélective
C07K 5/11 - Tétrapeptides la chaîne latérale du premier amino-acide contenant plus de groupes amino que de groupes carboxyle, ou leurs dérivés, p. ex. Lys, Arg
C07K 5/113 - Tétrapeptides la chaîne latérale du premier amino-acide contenant plus de groupes carboxyle que de groupes amino, ou leurs dérivés, p. ex. Asp, Glu, Asn
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
91.
COMPOSITIONS AND METHODS RELATING TO INHALABLE THERAPEUTIC COMPOSITIONS
The present disclosure provides compositions and methods related to inhalable therapeutics. In particular, the present disclosure provides hydrogel-based inhalable bioadhesives that safely and effectively coat the airway to provide a barrier against pathogenic organisms, allergens, and environmental pollutants.
A61K 47/14 - Esters d’acides carboxyliques, p. ex. acides gras monoglycérides, triglycérides à chaine moyenne, parabènes ou esters d’acide gras de PEG
A61K 47/32 - Composés macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. carbomères
Board of Trustees of Southern Illinois University (USA)
Inventeur(s)
Theis, Thomas
Abdulmojeed, Mustapha
Lehmkuhl, Sören
Tomhon, Patrick
Mandzhieva, Iuliia
Chekmenev, Eduard Y.
Adelabu, Isaiah
Kabir, Mohammad
Nantogma, Shiraz
Ettedgui, Jessica
Swenson, Rolf Eric
Goodson, Boyd
Abrégé
In one aspect, the disclosure relates to hyperpolarized target molecules and contrast agents comprising the same, methods of making the same, and methods of imaging using same. In a further aspect, imaging performed using the hyperpolarized target molecules and contrast agent can enable real time monitoring and diagnosis of diseases including various cancers and metabolic disorders. The methods are cryogen-free and inexpensive and can be performed in a short time. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
Devices, systems, and methods for characterizing material samples. In one aspect, a device for characterizing a sample includes a substrate configured for receiving a sample thereon; an optical fiber probe comprising a first end positioned near the sample and a second end that is bifurcated to include one or more first fiber configured for connection to a first light emitting device and one or more second fiber configured for connection to a spectrometer; a reflectance module coupled to the substrate; and a second light emitting device positioned near the sample. The optical fiber probe is configured for selectively obtaining at the spectrometer both a reflectance absorbance measurement of the sample associated with the first light emitting device and a photoluminescence measurement of the sample associated with the second light emitting device.
Cercis plant, referred to by its cultivar name, ‘NC2017-113’, is disclosed. The new variety is characterized by its white-colored flowers. The new variety is also characterized by its small, thick, glossy, and green-colored foliage. A moderately slow growing and compact growth habit is displayed.
‘XSA 11377’ is a new St. Augustinegrass cultivar that is fast to establish, has good levels of shade and drought tolerances, and has superior turf quality. It is distinguishable from other cultivars by its medium-fine texture, aggressive stoloniferous growth, improved sod strength, and improved shade tolerance. ‘XSA 11377’ shows gray leaf spot and chinch bug tolerance, and maintains above average turf quality under normal management practices. ‘XSA-11377’ is also genetically distinct from other St. Augustinegrass cultivars currently in the marketplace known to the Inventor.
Various examples are provided related to DC microgrid control. In one example, a system includes a mesh DC microgrid network having at least 4 microgrid DC nodes. The mesh DC microgrid network can be organized as clusters of three node DC microgrid systems, where each cluster include three of the at least 4 microgrid DC nodes. In each cluster, one of DC microgrid nodes is a pivot node that links remaining clusters together within the mesh DC microgrid network. Each DC microgrid node of the mesh DC microgrid network is directly connected to the pivot node. In another example, a mesh DC microgrid network includes one or two remaining microgrid DC nodes directly connected to a pivot node by a tie-line including a tie-line current sensor. One or more converters at the remaining DC microgrid nodes can be controlled using feedforward control with droop control using tie-line current sensor information.
Cercis plant, referred to by its cultivar name, ‘NC2017-92’, is disclosed. The new variety is characterized by its light, purple-colored flowers. The new variety is also characterized by its small and gold-colored foliage. A moderately slow growing, highly branched and compact growth habit is displayed.
h The present disclosure provides compositions, methods, and systems related to template-mediated genome editing and modification. In particular, the present disclosure provides novel genome modification technology involving site-specific chemical modification of a nucleotide to introduce a replication-blocking lesion. The compositions, methods, and systems described herein facilitate efficient site-specific genome modification of a DNA target, while minimizing the unintended edits and cellular toxicity associated with current genome editing approaches.
Disclosed are fibrin-specific nanogels. The fibrin-specific nanogels can comprise a fibrin binding moiety conjugated to a polymeric matrix (e.g., a crosslinked polyacrylamide matrix). By varying the morphology of fibrin-specific nanogels (e.g., by varying the crosslinker density and/or the three-dimensional structure of the fibrin-specific nanogels), fibrin-specific materials which mimic the biophysical characteristics of platelets can be formed. The resulting materials can be used in a variety of biomedical applications (e.g., for drug delivery, to promote wound healing, to treat thrombotic events, and to treat coagulative disorders).
A61K 47/69 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament le conjugué étant caractérisé par sa forme physique ou sa forme galénique, p. ex. émulsion, particule, complexe d’inclusion, stent ou kit
A61K 47/68 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un anticorps, une immunoglobuline ou son fragment, p. ex. un fragment Fc
A61L 26/00 - Aspects chimiques des bandages liquides ou utilisation de matériaux pour les bandages liquides
A61P 9/10 - Médicaments pour le traitement des troubles du système cardiovasculaire des maladies ischémiques ou athéroscléreuses, p. ex. médicaments antiangineux, vasodilatateurs coronariens, médicaments pour le traitement de l'infarctus du myocarde, de la rétinopathie, de l'insuffisance cérébro-vasculaire, de l'artériosclérose rénale
Spin coating systems and methods. In one aspect, a spin coater assembly is provided. The spin coater assembly includes a spinner configured for receiving a substrate thereon, a plurality of material dispensers, an arm assembly configured to selectively position one of the plurality of material dispensers over the substrate, and a controller in communication with each of the spinner, the plurality of material dispensers, and the arm assembly.