Abstract

A computer-implemented method for predicting customer sentiment for a product is provided. Customer data is received for multiple products and a vector of customer sentiments is generated that is associated with different aspects of the products. Images are received for multiple products and a latent vector for the images are generated using a pre-trained image processing model. Textual description for products is received and a latent vector for the textual description is generated using a pre-trained natural language processing model. A deep multimodal design evaluation (DMDE) model is designed to integrate the latent vectors of the images and the textual descriptions to predict customer sentiment for new product designs based on their images and textual descriptions. A new product design is provided to the trained DMDE model to obtain predicted customer sentiments for one or more attributes or a new product design is generated with favorable predicted customer sentiments.

IPC Classes  ?

• G06Q 30/0202 - Market predictions or forecasting for commercial activities
• G06Q 30/0203 - Market surveysMarket polls
• G06Q 30/0282 - Rating or review of business operators or products

Abstract

The present disclosure provides a robotic system for safe human-robot interaction. The system includes a robot body, a plurality of tactile sensors disposed on the robot body to detect contact, and a control system operatively connected to the tactile sensors. The control system receives tactile data from the tactile sensors, determines a safety action based on the tactile data, and controls the robot body to perform the safety action in response to detected contact. The safety action may comprise retracting the robot body away from a detected contact point. The control system can determine a contact force based on the tactile data and adjust a magnitude of the safety action based on the determined contact force. The system enables adaptive and responsive robot behavior to enhance safety during human-robot interactions.

IPC Classes  ?

• B25J 19/06 - Safety devices
• B25J 13/08 - Controls for manipulators by means of sensing devices, e.g. viewing or touching devices

Abstract

Methods, systems, and computer products are presented herein for generating a clock signal using an on-chip ultra-low power (ULP) RC oscillator. An on-chip ultra-low power (ULP) RC oscillator comprises a first comparator, a second comparator, and a flip flop. The first comparator comprises a first input electrically coupled to a first bias voltage generation circuit and a second input electrically coupled to a first capacitor circuit. Each of the first bias voltage and the second bias voltage directly varies with a thermal voltage. A flip-flop is electrically coupled to the first comparator and the second comparator. The flip-flop is configured to generate a clock signal based on the first and the second comparator output signals.

IPC Classes  ?

• H03B 5/04 - Modifications of generator to compensate for variations in physical values, e.g. power supply, load, temperature
• H03B 5/24 - Generation of oscillations using amplifier with regenerative feedback from output to input with frequency-determining element comprising resistance and either capacitance or inductance, e.g. phase-shift oscillator active element in amplifier being semiconductor device
• H03K 3/037 - Bistable circuits

Abstract

An apparatus and method for producing oriented polymer films are disclosed. The apparatus includes a curved enclosure configured to rotate and a flow obstacle. The curved enclosure has an interior volume with an opening at one end. The flow obstacle extends through the opening and interior volume, with one end rigidly coupled to a mounting plate. The flow obstacle's position is adjustable to contact the interior surface of the curved enclosure, defining a gap between them. The method involves introducing a material into the curved enclosure, adjusting the flow obstacle's position, and rotating the curved enclosure to generate an extensional flow within the material. The apparatus and method may be used for producing two-dimensional polymer films and can incorporate features such as inert gas flushing, heating systems, and various blade configurations for the flow obstacle.

IPC Classes  ?

• B29C 48/08 - Flat, e.g. panels flexible, e.g. films
• B29C 48/14 - Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired formApparatus therefor characterised by the particular extruding conditions, e.g. in a modified atmosphere or by using vibration
• B29C 48/30 - Extrusion nozzles or dies
• B29L 7/00 - Flat articles, e.g. films or sheets

Abstract

Disclosed are adhesive materials comprising a polymer and a filler; wherein a) if the temperature of the adhesive material is equal to or below a reference temperature, then the adhesive material adheres to an adherend; and b) if the temperature of the adhesive material is above the reference temperature, then the adhesive does not adhere to an adherend. Further disclosed are methods of making the adhesive materials.

IPC Classes  ?

• C09J 7/38 - Pressure-sensitive adhesives [PSA]
• C09J 5/06 - Adhesive processes in generalAdhesive processes not provided for elsewhere, e.g. relating to primers involving heating of the applied adhesive
• C09J 11/04 - Non-macromolecular additives inorganic

Abstract

Methods, systems, and computer program products are presented herein for circuit timing using ultra-low power (ULP) timing circuit systems. A ULP timing circuit system comprises a receiver circuit, phase lock loop (PLL) circuit, crystal oscillator (XO) circuit, temperature sensing and calibration circuit, and temperature compensation circuit. The receiver circuit is configured to receive a reference clock signal. The XO circuit is configured to produce an output clock signal. The PLL circuit is configured to produce a control signal based on the reference clock signal and output clock signal. The temperature compensation circuit is configured to produce a compensation signal based on an operating temperature. The temperature sensing and calibration circuit is configured to sense the operating temperature and to calibrate the XO circuit based on the operating temperature, control signal, and compensation signal to lock a frequency of the output clock signal to the reference clock signal.

IPC Classes  ?

• H03K 3/011 - Modifications of generator to compensate for variations in physical values, e.g. voltage, temperature
• H03K 5/135 - Arrangements having a single output and transforming input signals into pulses delivered at desired time intervals by the use of time reference signals, e.g. clock signals
• H03L 7/099 - Details of the phase-locked loop concerning mainly the controlled oscillator of the loop

Abstract

Methods, systems, and computer products are presented herein for determining temperature using ultra-low power temperature sensing systems. An ultra-low power (ULP) temperature sensing system comprises a proportional to absolute temperature (PTAT) current source, a switched-capacitor converter electrically coupled to the PTAT current source, and a ULP analog-to-digital converter (ADC) electrically coupled to the PTAT current source and the switched-capacitor converter. The PTAT current source is configured to generate a PTAT current that varies with an operating temperature. The switched-capacitor converter is configured to generate an analog voltage signal based on the PTAT current. The ULP ADC is configured to output a digital voltage value corresponding to the analog voltage signal.

IPC Classes  ?

• H03L 1/02 - Stabilisation of generator output against variations of physical values, e.g. power supply against variations of temperature only
• G05F 3/30 - Regulators using the difference between the base-emitter voltages of two bipolar transistors operating at different current densities
• H03M 1/46 - Analogue value compared with reference values sequentially only, e.g. successive approximation type with digital/analogue converter for supplying reference values to converter

Abstract

A high-throughput microfluidics-based fluorescence activated droplet sorting (FADS) system provides activation, sorting, and feeder cell-free expansion of NK cells that are enriched for killing activity. The NK cells are activated and identified based on their ability to kill target cells, such as tumor cells, without prior sensitization. The diversity of endogenous NK cells can be overcome to allow selection of a highly effective population of cells for therapeutic use, such as in the treatment of cancer.

IPC Classes  ?

• C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells
• G01N 15/149 - Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties
• C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus
• B01F 25/00 - Flow mixersMixers for falling materials, e.g. solid particles

Abstract

Provided herein are methods and systems for radio access network (RAN) control including receiving, at a base station controller deployed at a base station of the RAN, a data input corresponding to a real-time operational status of the base station; determining a locally optimal signal configuration of the base station; controlling the base station to change a configuration of a signaling component to implement the locally optimal signal configuration; receiving, at an edge controller deployed at an edge of the RAN, a plurality of the locally optimal signal configurations corresponding to a plurality of the base stations within the RAN; determining a coordinated optimal signal configuration of each base station; and instructing, by the edge controller, the base station controller to change a configuration of the signaling component of the base station from the locally optimal signal configuration to the coordinated optimal signal configuration.

IPC Classes  ?

• H04W 72/044 - Wireless resource allocation based on the type of the allocated resource
• H04W 24/02 - Arrangements for optimising operational condition

Abstract

Systems, computer program products, and methods are disclosed for predicting a location of a target device. A method comprises sending a short message service (SMS) to a target device, via a short message service center (SMSC); receiving, from the target device and through the SMSC, a delivery report; providing the delivery report as an input to a pretrained machine learning model; deriving one or more fingerprints from the delivery report, thereby creating a target data model based on the one or more fingerprints; predicting, based on the target data model, a location of the target device.

IPC Classes  ?

• H04W 4/14 - Short messaging services, e.g. short message service [SMS] or unstructured supplementary service data [USSD]
• H04W 24/02 - Arrangements for optimising operational condition
• H04W 64/00 - Locating users or terminals for network management purposes, e.g. mobility management

Abstract

Provided herein are programmable intelligent surfaces (PIS) for transmitting power and/or signals to a device positioned on or proximate the surface including at least one resonant unit including a power distribution layer having at least one transmitter coil configured to be energized by a power source and generate an electromagnetic field sized to electrically interact with at least one meta-cell coil of a meta-resonance layer, and the meta-resonance layer extending over the power distribution layer and comprising an array of configurable meta-cells, each including at least one of the meta-cell coils configured to selectively amplify, block, modify, or pass unchanged the electromagnetic field generated by the transmitter coil.

IPC Classes  ?

• H02J 50/12 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling of the resonant type
• H02J 50/00 - Circuit arrangements or systems for wireless supply or distribution of electric power
• H02J 50/40 - Circuit arrangements or systems for wireless supply or distribution of electric power using two or more transmitting or receiving devices
• H02J 50/90 - Circuit arrangements or systems for wireless supply or distribution of electric power involving detection or optimisation of position, e.g. alignment

Abstract

Devices, systems, and methods can be used for the automated production of dendritic cells (DC) from dendritic cell progenitors, such as monocytes obtained from peripheral blood. The invention makes it possible to obtain sufficient quantities of a subject's own DC for use in preparing and characterizing vaccines, for activating and characterizing the activation state of the subject's immune response, and to aid in preventing and/or treating cancer or infectious disease.

IPC Classes  ?

• C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• C07K 14/525 - Tumour necrosis factor [TNF]
• C07K 14/535 - Granulocyte CSFGranulocyte-macrophage CSF
• C07K 14/54 - Interleukins [IL]
• C07K 14/545 - IL-1
• C12M 1/00 - Apparatus for enzymology or microbiology
• C12M 1/22 - Petri dishes
• C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus
• C12M 3/06 - Tissue, human, animal or plant cell, or virus culture apparatus with filtration, ultrafiltration, inverse osmosis or dialysis means
• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
• C12N 5/0784 - Dendritic cellsProgenitors thereof

Abstract

Provided herein are, in various embodiments, are bottlebrush polymer-oligonucleotides conjugates. In certain embodiments, the conjugates are potent in vivo, have improved biopharmaceutical properties, enhanced transfection efficiency, and/or an unconventional biodistribution profile. Also provided herein are pharmaceutical compositions, methods of treatment, and methods of making bottlebrush polymer-oligonucleotide conjugates.

IPC Classes  ?

• A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• C12N 15/115 - Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith

Abstract

A system and method for joint dynamic interest request forwarding and dynamic cache placement and eviction and provided within the context of the Named Data Networking (NDN) architecture. The system and method employ a virtual control plane that operates on the user demand rate for data objects in the network, and an actual plane that handles Interest Packets and Data Packets. Distributed algorithms within the virtual plane achieve network load balancing through dynamic forwarding and caching, thereby maximizing the user demand rate that the NDN network can satisfy. A method of congestion control is also provided to achieve optimal network fairness using the VIP framework.

IPC Classes  ?

• H04L 67/568 - Storing data temporarily at an intermediate stage, e.g. caching
• H04L 45/02 - Topology update or discovery
• H04L 45/586 - Association of routers of virtual routers
• H04L 45/64 - Routing or path finding of packets in data switching networks using an overlay routing layer
• H04L 47/27 - Evaluation or update of window size, e.g. using information derived from acknowledged [ACK] packets

Abstract

A method of determining an extent of visual spatial neglect of a patient includes providing a software-based test to the patient via a presentation apparatus positioned on the head of the patient and having a display device positioned close and in front of the eyes of the patient. EEG information is collected from the patient during the test via an EEG apparatus positioned on the head of the patient. Portions of the EEG information collected during the test are used to determine the extent of the visual spatial neglect of the patient. An indication of the extent of the visual spatial neglect of the patient is provided.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/378 - Visual stimuli

Abstract

Provided herein are methods and systems for a computer implemented method for designing and optimizing a fabrication process characterized by one or more process parameters. The outcome of the fabrication process is characterized by a quality metric used to optimize the fabrication process. The method uses a classification model in conjunction with a regression model, both using artificial intelligence and trained using experimental results, to iteratively recommend process parameter values for performing real world fabrication experiments. The experimental results are used to continuously train the models. The outcome is a set of process parameters that yield an optimal fabrication process with less time and effort than using conventional design of experiment methods.

IPC Classes  ?

• G06F 30/27 - Design optimisation, verification or simulation using machine learning, e.g. artificial intelligence, neural networks, support vector machines [SVM] or training a model
• G06F 18/2415 - Classification techniques relating to the classification model, e.g. parametric or non-parametric approaches based on parametric or probabilistic models, e.g. based on likelihood ratio or false acceptance rate versus a false rejection rate

Abstract

A hierarchical hydroxyapatite inorganic radiative cooling (HIRC) metapaper achieves efficient radiative cooling and enhanced thermal dissipation to accelerate heat release.

IPC Classes  ?

• D21H 17/68 - Water-insoluble compounds, e.g. fillers or pigments siliceous, e.g. clays
• D21H 11/18 - Highly hydrated, swollen or fibrillatable fibres
• D21H 21/52 - Additives of definite length or shape
• D21H 25/04 - Physical treatment, e.g. heating or irradiating

Abstract

A quantitative, ultrashort time to echo, contrast-enhanced magnetic resonance imaging technique is provided. The technique can be used to accurately measure contrast agent concentration in the blood, to provide clear, high-definition angiograms, and to measure absolute quantities of cerebral blood volume on a voxel-by-voxel basis.

IPC Classes  ?

• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• G01R 33/48 - NMR imaging systems
• G01R 33/56 - Image enhancement or correction, e.g. subtraction or averaging techniques
• G01R 33/563 - Image enhancement or correction, e.g. subtraction or averaging techniques of moving material, e.g. flow-contrast angiography

Abstract

Systems and methods for high throughput microdroplet-based single cell assays in microdroplets are provided. The system and methods use parallel devices and switches to enable simultaneous analysis of different cells or cell combinations, or different assay conditions, on a single microfluidic chip. Interconnections between the inlets of individual devices on a common chip enable simultaneous screening of the effect of different combinations of drugs on single cells. The use of an oil inlet and microchannels with matched total flow resistance allows the synchronous generation of droplets with the same dimensions and/or volumes.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Abstract

A composition of an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate encapsulated in an oil-in-water nanoemulsion (NE) drug delivery system. A method of treating cancer by administering an effective amount of a pharmaceutical composition including a PUFA-taxoid conjugate encapsulated in an oil-in-water NE drug delivery system to a subject in need of treatment, and treating cancer. A method of overcoming multidrug resistance by exposing a multidrug resistant cell to an effective amount of a pharmaceutical composition including an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate encapsulated in an oil-in-water NE drug delivery system, and inducing the death of the multidrug resistant cell. A method of eliminating a cancer stem cell. Methods of reducing stemness of a cancer stem cell, retaining drug in the body, and providing a slower release profile.

IPC Classes  ?

• A61K 9/107 - Emulsions
• A61K 9/51 - Nanocapsules
• A61K 31/337 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
• A61K 47/12 - Carboxylic acidsSalts or anhydrides thereof
• A61K 47/44 - Oils, fats or waxes according to two or more groups of Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
• A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit

Abstract

Methods, systems, and computer program products are presented herein for obfuscating analog circuits using switched phase circuits. In particular, methods, systems, and computer program products using a Switch Mode Time Domain Locking (SMDL) scheme, presented herein, may be used to protect analog circuits. A first input signal to an analog circuit is generated. The first input signal comprises a reference phase. The analog circuit is adapted to perform a predetermined function. A second input signal to the analog circuit is generated. The second input signal comprises a provided phase. Enablement of the predetermined function of the analog circuit is toggled based on alignment of the reference phase and the provided phase.

IPC Classes  ?

• G06F 21/70 - Protecting specific internal or peripheral components, in which the protection of a component leads to protection of the entire computer

Abstract

A method of delivering a therapeutic agent into the central nervous system through the blood-brain barrier includes implanting an implant within the submucosal space of the olfactory epithelium. The implant can provide sustained drug delivery to the brain. The implant can be placed using a minimally invasive surgical approach.

IPC Classes  ?

• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers

Abstract

High capacity, low cost devices for use in growing monocultures of novel, previously unknown microbial species contain adhesive layers with wells covered by nanoporous membranes. The devices are placed in natural environments for cultivation of unknown microbial species.

IPC Classes  ?

• C12M 1/00 - Apparatus for enzymology or microbiology
• C12M 1/04 - Apparatus for enzymology or microbiology with gas introduction means
• C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means

Abstract

Compounds able to modulate the endocannabinoid system, their preparation and method of use in the treatment and prevention of diseases in which modulation of the receptor is beneficial are described. Also described are pharmaceutically acceptable compositions comprising the disclosed compounds and methods of using said compositions in the treatment of various disorders, diseases, or conditions, in which modulation of the endocannabinoid system is beneficial.

IPC Classes  ?

• C07D 209/10 - IndolesHydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
• C07D 209/14 - Radicals substituted by nitrogen atoms, not forming part of a nitro radical
• C07D 409/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• A61P 25/00 - Drugs for disorders of the nervous system
• A61K 31/404 - Indoles, e.g. pindolol

Abstract

The invention relates to a device for magnetic pose estimation of an object in a measurement volume to which a reference magnetic field is applied, comprising: at least four electrically activatable magnetic-field generators having various predetermined poses in the edge region of the measurement volume; at least one magnetic-field sensor rigidly connected to the object; a control unit for predeterminable electrical activation of the magnetic-field generators; and an evaluation unit for receiving and evaluating the electrical output signal from the at least one magnetic-field sensor; a. the at least one magnetic-field sensor being in the form of a magnetoelectric bending-beam sensor having a known mechanical resonant frequency for simultaneously measuring three linearly independent components of the reference magnetic field; and b. the control unit being designed to perform the electrical activation of the magnetic-field generators in a band-limited manner close to the mechanical resonant frequency of the magnetic field sensor; and c. the evaluation unit being designed to estimate from the output signal from the at least one magnetic-field sensor, using predetermined and tabulated matched filters, the pose of the object in the measurement volume; d. at least four of the magnetic-field generators being in the form of magnetoelectric transmitters.

IPC Classes  ?

• A61B 34/20 - Surgical navigation systemsDevices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
• G01R 33/02 - Measuring direction or magnitude of magnetic fields or magnetic flux
• A61B 17/00 - Surgical instruments, devices or methods
• G01B 7/004 - Measuring arrangements characterised by the use of electric or magnetic techniques for measuring coordinates of points
• G01B 7/30 - Measuring arrangements characterised by the use of electric or magnetic techniques for measuring angles or tapersMeasuring arrangements characterised by the use of electric or magnetic techniques for testing the alignment of axes

Abstract

Embodiments disclose a pore sensing fluidic device. The pore sensing fluidic device includes a structure defining a common inflow channel, shared channel with a plurality of apertures, a plurality of recording chambers, a common return channel, and a plurality of control channels arranged to support a fluid flow within the structure. The plurality of control channels connects the common inflow channel to the shared channel and the plurality of recording chambers. The fluidic device includes a sealer configured to isolate the plurality of recording chambers from the plurality of control channels. A membrane is formed and coupled to each of the plurality of apertures, and a pore is inserted into each membrane. A sensor, coupled to each of the plurality of apertures, is configured to produce a representation of flow through each of the plurality of membrane pores.

IPC Classes  ?

• B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
• G01N 33/487 - Physical analysis of biological material of liquid biological material
• C12Q 1/6869 - Methods for sequencing

Abstract

Plasmodium falciparumPlasmodium falciparumPlasmodium Plasmodium species. In another aspect, the compounds are soluble in aqueous solutions at pH 7.4, making them suitable for oral administration to patients. Also disclosed are methods of making the compounds, pharmaceutical compositions comprising the same, and methods of treating or preventing malaria using the same. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Abstract

Plasmodium Plasmodium spp. in the parasite's various stages, such as, for example, the erythrocytic and exoerythrocytic stages, and pharmaceutical compositions comprising same. In one aspect, the compounds are tetrahydroacridinones having the structure I described herein. In another aspect, the compounds described herein can be used to treat or prevent malaria in a subject.

IPC Classes  ?

• C07D 219/10 - Nitrogen atoms attached in position 9
• A61K 31/473 - QuinolinesIsoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
• A61P 33/06 - Antimalarials

Abstract

An all solid-state Li metal microbattery is fabricated by directed assembly-based printing of nanoparticles on a substrate, which facilitates the fabrication of all battery components, including cathode, anode, and solid electrolyte at microscale dimensions and without the need for costly and complex fabrication techniques. The porous cathode material allows polymer electrolyte to be intercalated within the cathode, resulting in a cathode-supported electrolyte membrane which enhances battery performance through superior ionic transport, low interfacial resistance between the electrolyte and the cathode, and providing electronic pathways through the cathode framework.

IPC Classes  ?

• H01M 50/11 - Primary casingsJackets or wrappings characterised by their shape or physical structure having a chip structure, e.g. micro-sized batteries integrated on chips
• H01M 4/02 - Electrodes composed of, or comprising, active material
• H01M 4/04 - Processes of manufacture in general
• H01M 4/36 - Selection of substances as active materials, active masses, active liquids
• H01M 4/58 - Selection of substances as active materials, active masses, active liquids of inorganic compounds other than oxides or hydroxides, e.g. sulfides, selenides, tellurides, halogenides or LiCoFySelection of substances as active materials, active masses, active liquids of polyanionic structures, e.g. phosphates, silicates or borates
• H01M 4/587 - Carbonaceous material, e.g. graphite-intercalation compounds or CFx for inserting or intercalating light metals
• H01M 10/0565 - Polymeric materials, e.g. gel-type or solid-type
• H01M 10/058 - Construction or manufacture

Abstract

The invention provides cell culture chambers and methods of use thereof. In certain embodiments, the cell culture chambers and methods provide for an expansion and stimulation of T-cells using autologous antigen-presented cells to provide a therapeutic T-cell product that can mobilize a patient's own immune system in a manner that selectively targets a patient's tumor.

IPC Classes  ?

• C12M 1/00 - Apparatus for enzymology or microbiology
• C12M 1/04 - Apparatus for enzymology or microbiology with gas introduction means
• C12M 1/26 - Inoculator or sampler
• C12M 1/36 - Apparatus for enzymology or microbiology including condition or time responsive control, e.g. automatically controlled fermentors
• C12M 1/42 - Apparatus for the treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic wave

Abstract

A system and method for assessing properties of particles, the system comprising: a first structure defining an interior cavity, configured to contain an interior cavity fluid, and a barrier separating the interior cavity from an exterior cavity configured to contain an exterior cavity fluid, the barrier defining a nanopore therethrough fluidically coupling the interior and exterior cavities, the first structure further comprising at least one feature configured to interface with at least one complementary feature of a second structure that defines the exterior cavity; and electrodes configured to energize and apply a voltage gradient across the nanopore between the interior cavity and exterior cavity, the voltage gradient of sufficient magnitude to induce particles to migrate via the nanopore between the interior cavity and the exterior cavity and produce an electronic signature representative of at least one property of the particles.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters

Abstract

The present technology provides a genetically modified immune cell expressing a chimeric antigen receptor (CAR) and also expressing an elevated level of a ligand for a tumor necrosis factor (TNF) receptor. The genetically modified cell takes advantage of dual pathways for killing cancer cells, cellular pathogens, and cells infected with viruses. The CAR- mediated pathway promotes killing action by perforin and granzymes released by cytotoxic T lymphocytes and natural killer cells, as well as the TNF receptor (i.e., death domain) mediated target cell killing by these same cells. Further, the present technology, especially when combined with single cell image analysis, microfluidics based cell sorting, and transcriptomic analysis makes it possible to adapt genetic modifications to cells of a patient, in response to significant patient to patient variation in gene expression of T cells and NK cells.

IPC Classes  ?

• A61K 35/17 - LymphocytesB-cellsT-cellsNatural killer cellsInterferon-activated or cytokine-activated lymphocytes
• A61P 35/00 - Antineoplastic agents
• C07K 19/00 - Hybrid peptides
• C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells
• C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
• C07K 14/705 - ReceptorsCell surface antigensCell surface determinants

Abstract

In a process for manufacturing molded ceramic composite materials, a preform of a ceramic composite material is provided in which ceramic particles having a platelet configuration are formed within a ceramic matrix. The preform is thermoformed within a mold by heating to a temperature greater than a melting or softening temperature of the ceramic matrix and applying a load to deform the preform to form the molded ceramic composite material in a desired configuration. The process is used to fabricate precisely molded ceramic composite materials and devices containing them. The materials and devices can be used for thermal management, such as for electronic components and other heat generating structures.

IPC Classes  ?

• B28B 1/14 - Producing shaped articles from the material by simple casting, the material being neither forcibly fed nor positively compacted
• B28B 11/00 - Apparatus or processes for treating or working the shaped articles
• C04B 35/634 - Polymers
• C04B 35/638 - Removal thereof
• C04B 35/64 - Burning or sintering processes

Abstract

A method for broadband, high-efficiency spin wave transduction adopts a slow-wave structure to enhance the interaction of electromagnetic waves and spin waves.

IPC Classes  ?

• H01P 7/00 - Resonators of the waveguide type
• H01P 3/08 - MicrostripsStrip lines

Abstract

Provided herein are methods and systems for deployment and orchestration of network intelligence in an Open RAN including receiving requests at a request collector, selecting one, by an orchestration engine, or more ML/Al models applicable for satisfying the plurality of collected requests, assigning at least one Open RAN resource to execute each of the ML/Al models, automatically generating, by an orchestration engine, executable software components embedding at least one of the ML/Al models, dispatching each executable software component to the assigned Open RAN resource, and instantiating, at the Open RAN resource, at least one of the ML/AI models embedded in the executable software component to configure the Open RAN to satisfy the requests.

IPC Classes  ?

• G06N 20/00 - Machine learning

Abstract

An on-chip acoustic delay line (ADL) for operation in the radio frequency (RF) range uses a two-dimensional array of resonant rods and a piezoelectric layer having corrugated structure. The ADL has one or more programmable passband frequencies which are determined by the lithographically-defined artificial dispersive characteristics of acoustic metamaterials formed by forests of the locally resonant rods and selectable attached matching networks. The ADL devices offer exceptionally high fractional bandwidth and low insertion loss. The ADL can be used in self-interference cancellation networks to provide full duplex radio.

IPC Classes  ?

• H03H 9/40 - Frequency-dependent delay lines, e.g. dispersive delay lines
• H03H 3/02 - Apparatus or processes specially adapted for the manufacture of impedance networks, resonating circuits, resonators for the manufacture of electromechanical resonators or networks for the manufacture of piezoelectric or electrostrictive resonators or networks

Abstract

Systems and methods are provided for in-bed pose and posture determination and tracking for a human subject including an imaging device, the imaging device positioned proximate to a bed and oriented to capture images of the subject lying in the bed, and a processing unit operative to receive the captured images, the captured images including a plurality of image frames, the processing unit including a pose estimation module trained with a dataset of lying poses and operative to estimate poses of the subject lying in the bed based the image frames, and a posture classification module trained with the dataset of lying poses and operative to classify positions of the subject lying in the bed based on the image frames, the processing unit operative to determine a pose and posture of the subject lying in the bed.

IPC Classes  ?

• G06V 20/50 - Context or environment of the image
• G06V 10/50 - Extraction of image or video features by performing operations within image blocksExtraction of image or video features by using histograms, e.g. histogram of oriented gradients [HoG]Extraction of image or video features by summing image-intensity valuesProjection analysis
• G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
• G06V 10/94 - Hardware or software architectures specially adapted for image or video understanding
• G06V 40/10 - Human or animal bodies, e.g. vehicle occupants or pedestriansBody parts, e.g. hands

Abstract

In embodiments, a method includes the following operations. For each qubit gate of a quantum circuit within a qubit frontier of a circuit operation of qubit gates of the circuit, the method (a) determines a set of three-or-more-qubit blocks from the qubit frontier to an interior of the circuit, (b) determines a number of operations of a subset of blocks in the set of three-or-more-qubit blocks, (c) determines a family of blocks with a highest number of operations, (d) for each respective three-or-more-qubit block of the set, determines a block family with a highest number of available operations that starts with the respective three-or-more-qubit block and adheres to restriction zones of the blocks, and (e) adds a three-or-more-qubit block having a highest number of operations to a blocked circuit. Each qubit gate is a one-or-two-qubit gate of fewer bits than a number of bits of the three-or-more-qubit blocks.

IPC Classes  ?

• G06N 10/40 - Physical realisations or architectures of quantum processors or components for manipulating qubits, e.g. qubit coupling or qubit control

Abstract

A computer-based system and corresponding computer-implemented method for training a user via an emulated real-world building environment are provided. Based on an initial training input from a trainer user, a building simulation model is implemented. The building simulation model is configured to produce an emulated real-world building environment. For an iteration of the building simulation model, a value of at least one forcing function is determined. The at least one forcing function is associated with the emulated real-world building environment. Based on the value of the at least one forcing function determined and at least one building operation input received from a trainee user via a building training interface, a current state of the building simulation model is transformed into an updated state of the building simulation model. Based on the updated state and the initial training input, at least one building training item is generated for the trainee user.

IPC Classes  ?

• G09B 9/00 - Simulators for teaching or training purposes
• G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer

Abstract

The present disclosure generally relates to mixtures and compositions comprising sulforaphane, or analogue thereof, and at least one amino acid, or analogue thereof. In particular, the disclosure relates the use of the mixtures and compositions for treating or preventing oxidative stress.

IPC Classes  ?

• A61K 31/26 - Cyanate or isocyanate estersThiocyanate or isothiocyanate esters
• A61K 31/198 - Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
• A61P 39/06 - Free radical scavengers or antioxidants

Abstract

Provided herein are methods and systems for a hard drive failure prediction system to determine a predicted hard drive failure within a time-in-advance determined time period. The system includes a machine-learning model, such as an XGBoost model, trained using historical hard drive operational data from a data center. The historical hard drive operation data corresponds to SMART attributes. Statistical analysis is performed to determine a set of SMART attributes most indicative of hard drive failure. The model is trained using the historical hard drive operational data corresponding to the set of SMART attributes. The accuracy results of the model are used to determine a time-in-advance value that balances accuracy with failure lead time. A signal length of operational data for a particular hard drive is provided as input to the trained model and an output indicates if the hard drive will fail within the time period of the time-in-advance value.

IPC Classes  ?

• G06F 3/06 - Digital input from, or digital output to, record carriers

Abstract

Embodiments disclosed herein may be implemented in the form of a method or corresponding apparatus for receiving or transmitting network communications carried at acoustic wavelengths via an acoustic medium. The corresponding method or apparatus may include a gate-level digital hardware module communicatively coupled to a communications module and define therein logic blocks configured to perform respective primitive processing functions, sequences of the logic blocks being capable of processing data units in accordance with any of the multiple communications protocols on a data unit-by-data unit basis without reconfiguring. According to some embodiments, the gate-level digital hardware module may be configured to process a data unit in accordance with a first communications protocol by directing the data unit through a first sequence of logic blocks, and process a subsequent data unit in accordance with a second communications protocol by directing the subsequent data unit through a second of sequence logic blocks.

IPC Classes  ?

• H04B 11/00 - Transmission systems employing ultrasonic, sonic or infrasonic waves
• H04B 13/02 - Transmission systems in which the medium consists of the earth or a large mass of water thereon, e.g. earth telegraphy
• H04B 14/04 - Transmission systems not characterised by the medium used for transmission characterised by the use of pulse modulation using pulse code modulation

Abstract

Voltage-gated sodium (NaV) channels are densely expressed in most excitable cells and activate in response to depolarization, causing a rapid influx of Na+ ions that initiates the action potential. The voltage-dependent activation of NaV channels is followed almost instantaneously by fast inactivation, setting the refractory period of excitable tissues. The gating cycle of NaV channels is subject to tight regulation, with perturbations leading to a range of pathophysiological states. The gating properties of most ion channels are regulated by the membrane phospholipid, phosphatidylinositol (4,5) bisphosphate (PI(4,5)P2). However, it is not known whether PI(4,5)P2 modulates the activity of NaV channels. Here, we utilize optogenetics to activate specific, membrane-associated phosphoinositide (PI)-phosphatases that dephosphorylate PI(4,5)P2 while simultaneously recording NaV1.4 channel currents. We show that dephosphorylating PI(4,5)P2 left-shifts the voltage-dependent gating of NaV1.4 to more hyperpolarized membrane potentials, augments the late current that persists after fast inactivation, and speeds the rate at which channels recover from fast inactivation. These effects are opposed by exogenous diC8PI(4,5)P2. We provide evidence that PI(4,5)P2 is a negative regulator that tunes the gating behavior of NaV1.4 channels.

IPC Classes  ?

• A61K 31/683 - Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
• A61K 31/10 - SulfidesSulfoxidesSulfones
• A61K 31/132 - Amines, e.g. amantadine having two or more amino groups, e.g. spermidine, putrescine
• A61K 31/137 - Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine
• A61K 31/235 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
• A61K 31/265 - Esters, e.g. nitroglycerine, selenocyanates of carbonic, thiocarbonic or thiocarboxylic acids, e.g. thioacetic acid, xanthogenic acid, trithiocarbonic acid
• A61K 31/27 - Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, e.g. meprobamate, carbachol, neostigmine
• A61K 31/365 - Lactones
• A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
• A61K 31/685 - Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
• A61K 31/7036 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
• A61P 9/06 - Antiarrhythmics
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Abstract

Disclosed are methods of treating or preventing a cardiovascular disease. The method may comprise administering to a subject in need thereof an effective amount of a compound. The compound may be a SUMOylation inhibitor, an analogue of Phosphatidylinositol 4,5-bisphosphate (PIP2); PIP2; or a compound that increases endogenous PIP2.

IPC Classes  ?

• A61K 31/7034 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
• A61P 9/12 - Antihypertensives

Abstract

Hybrid nanopores, comprising a protein pore supported within a solid-state membrane, which combine the robust nature of solid-state membranes with the easily tunable and precise engineering of protein nanopores. In an embodiment, a lipid-free hybrid nanopore comprises a water soluble and stable, modified portal protein of the Thermus thermophilus bacteriophage G20c, electrokinetically inserted into a larger nanopore in a solid-state membrane. The hybrid pore is stable and easy to fabricate, and exhibits low peripheral leakage, allowing sensing and discrimination among different types of biomolecules.

IPC Classes  ?

• G01N 33/487 - Physical analysis of biological material of liquid biological material
• B81B 1/00 - Devices without movable or flexible elements, e.g. microcapillary devices
• B82Y 15/00 - Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
• C07K 14/005 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from viruses
• C12Q 1/6869 - Methods for sequencing

Abstract

Provided herein are methods and systems for recognizing an infant action in a recorded video. The infant action recognition technique includes performing pose estimation for each frame of the video, where pose corresponds to skeletal joint locations and joint angles. A posture classifier uses the pose estimations to classify each pose estimation as one of five postures and a probability value for the posture. The infant action recognition technique further includes using the identified postures for each frame and the probability values to determine a period of uncertainty that corresponds to a transition segment. The infant action recognition technique further includes using the first and last frames of the transition segment to distinguish start and end stable postures. The technique further includes performing filtering and majority voting to remove outlier posture classifications and determine an infant action label for the video based on the start and end stable postures.

IPC Classes  ?

• A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

Disclosed are methods of culturing cells. The methods may comprise providing the cells and a culture incubator comprising a cell culture container; and an inflow of gas, wherein the cells are contained in the cell culture container. The methods may further comprise providing a continuous inflow of a cell culture gas to the culture incubator, incubating the cells in the culture incubator, monitoring the pericellular oxygen concentration of the cells in the cell culture container, and adjusting the inflow of the cell culture gas, thereby adjusting the pericellular oxygen concentration to a target oxygen concentration. Disclosed are culture incubators, comprising a cell culture container; and an inflow of gas, wherein cells are contained in the cell culture container.

IPC Classes  ?

• C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
• C12M 1/00 - Apparatus for enzymology or microbiology

Abstract

The present technology provides solidly-mounted, bi-dimensional mode acoustic resonators for use in high frequency electronic applications. The resonator devices are designed to constrain acoustic energy in the piezoelectric layer and electrodes. By concentration of the acoustic waves on the surface and reducing substrate leakage, the quality factor of the system is maintained, even at high frequencies where other resonators fail. The resonance frequency of the devices can be tuned in the 1-27 GHz range. Fabrication of the devices is simplified and cost reduced compared to similar technologies, because the piezoelectric layer is solidly supported and does not have to be released from the substrate.

IPC Classes  ?

• H03H 9/25 - Constructional features of resonators using surface acoustic waves
• H03H 9/02 - Networks comprising electromechanical or electro-acoustic elementsElectromechanical resonators Details

Abstract

A biosensor that is configured to be implanted into a living being includes a light source configured to generate source light with a source light spectrum. The biosensor also includes plasmonic nano-antenna optically coupled to the light source to receive the source light and to emit light therefrom exhibiting a spectral signature of the plasmonic nano¬antenna. A bio-functionalized element joined to the plasmonic nano-antenna can receive a biomarker if available and effect a change in the spectral signature as a function of receipt or nonreceipt of the biomarker. A combination of the light source and nano-antenna can encode an optical communication signal into the emitted light and transmit the signal to a separate communication node. An optional detector can detect the emitted light and provide output indicative of receipt or nonreceipt of the biomarker, which can in turn be encoded into the communication signal for reporting to another node.

IPC Classes  ?

• A61B 5/1459 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

Described herein is a sensor comprising a porous substrate comprising xanthommatin or a salt or a crosslinked derivative thereof. The sensor can be fabricated by distributing xanthommatin or a salt thereof throughout the porous substrate, and optionally crosslinking the distributed xanthommatin or a salt thereof. The sensors can be incorporated into microfluidic devices and/or used as wearable or mountable solar radiometers and/or UVC radiation detectors.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

Abstract

Provided herein are methods and systems for identifying one or more unused or underused portions of a wireless radio frequency (RF) spectrum including providing a multi-label multi-class machine learning classifier trained using a set of RF transmission data, receiving, by a receiver, wireless RF signals in an environment suspected of containing unused or underused portions of said RF spectrum, classifying the received wireless RF signals using the classifier; and identifying unused or underused portions of said RF spectrum.

IPC Classes  ?

• H04W 24/02 - Arrangements for optimising operational condition
• G06N 3/0464 - Convolutional networks [CNN, ConvNet]
• G06N 3/08 - Learning methods
• H04B 1/12 - Neutralising, balancing, or compensation arrangements

Abstract

4-phenyl-2-dimethylaminotetralin compounds, formulations, and methods are provided for selective modulation of serotonin 5-HT2A and 5-HT2C receptors without causing sedation at doses that are antipsychotic. Mechanisms for selective modulation are shown to involve inverse agonism at one or more of the 5-HT2A-2C receptors based on stereochemistry and substituents. The technology can be targeted to receptors inside or outside the central nervous system.

IPC Classes  ?

• C07D 213/38 - Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
• A61K 31/135 - Amines, e.g. amantadine having aromatic rings, e.g. methadone
• A61K 31/341 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
• A61K 31/381 - Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
• A61K 31/4409 - Non-condensed pyridinesHydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
• C07C 211/42 - Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems with six-membered aromatic rings being part of the condensed ring systems
• C07C 211/49 - Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring having at least two amino groups bound to the carbon skeleton
• C07D 307/52 - Radicals substituted by nitrogen atoms not forming part of a nitro radical
• C07D 333/20 - Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

Abstract

Systems and methods for controlled delivery of a specified quantity of particles. Systems involve a flow cell containing primary and secondary fluid chambers separated by a membrane, and a flow-producing module to induce particle translocation. Methods involve translocating particles between chambers through membrane activation, potentially for sorting and dispensing into target containers.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• G01N 15/10 - Investigating individual particles

Abstract

Described is a new family of fiber-reinforced composites/mechanical metamaterials with negative Poisson's ratio.

IPC Classes  ?

• C08K 7/02 - Fibres or whiskers
• B33Y 70/00 - Materials specially adapted for additive manufacturing
• B33Y 80/00 - Products made by additive manufacturing

Abstract

A compound having the following structure: A compound having the following structure: A compound having the following structure: R1 is a hydrocarbon group containing at least one aromatic or heteroaromatic ring or fused ring system, wherein the at least one aromatic or heteroaromatic ring or fused ring system is optionally substituted; R2 and R3 are independently selected from the group consisting of hydrogen (H), halogen atom, and hydrocarbon groups containing 1-6 carbon atoms and optionally substituted; R4 and R5 are independently selected from H, halogen atom, and hydrocarbon groups containing 1-6 carbon atoms and optionally substituted; R6 is H or a hydrocarbon group containing 1-12 carbon atoms and optionally containing one or more heteroatoms selected from O, N, S, and F; and Ra, Rb, Rc, and Rd are independently selected from H; halogen atom; hydrocarbon groups containing 1-3 carbon atoms; amine groups; amide groups; and —(CH2)p—T groups, wherein T is a hydrocarbon group with —NH— linkage; and pharmaceutically acceptable salts thereof.

IPC Classes  ?

• C07D 401/06 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
• A61K 31/235 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
• A61K 31/337 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
• A61K 31/427 - Thiazoles not condensed and containing further heterocyclic rings
• A61P 31/14 - Antivirals for RNA viruses
• C07C 241/04 - Preparation of hydrazides
• C07D 305/08 - Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring atoms
• C07D 409/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• C07D 417/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• C12N 9/99 - Enzyme inactivation by chemical treatment

Abstract

Wireless power transfer (WPT) efficiency is enhanced using an ultra-low power (ULP) distributed beamforming technique. A phase and frequency offset correction technique is used for beam-forming optimization, a backscattering communication technique is used to reduce power over-head, and a new rectifier and MPT method is used for high efficiency RF-to-DC conversion.

IPC Classes  ?

• H02J 50/20 - Circuit arrangements or systems for wireless supply or distribution of electric power using microwaves or radio frequency waves
• H01Q 3/22 - Arrangements for changing or varying the orientation or the shape of the directional pattern of the waves radiated from an antenna or antenna system varying the orientation in accordance with variation of frequency of radiated wave
• H02J 50/40 - Circuit arrangements or systems for wireless supply or distribution of electric power using two or more transmitting or receiving devices
• H02J 50/80 - Circuit arrangements or systems for wireless supply or distribution of electric power involving the exchange of data, concerning supply or distribution of electric power, between transmitting devices and receiving devices

Abstract

A robot comprises a body comprising a scalable joint module having a housing including an actuator within the housing powered by a voltage regulator on the housing and defining a female connector cavity of the housing; a first plurality of axial thrust roller bearings on the housing and a second plurality of axial thrust roller bearings on an opposite side of the housing, wherein each of the first and second plurality of axial thrust roller bearings are sandwiched between two washers; a male connector opposite from the female connector cavity; a head module coupled to the body, containing an onboard computing system controlling the movement of the lunar exploration robot, and an actuated latching mechanism; and a tail module coupled to the body, wherein the tail module defines a cavity configured for the actuated latching mechanism of the head module to enter, to thereby couple the head and tail modules.

IPC Classes  ?

• B62D 57/02 - Vehicles characterised by having other propulsion or other ground-engaging means than wheels or endless track, alone or in addition to wheels or endless track with ground-engaging propulsion means, e.g. walking members
• B64G 1/00 - Cosmonautic vehicles

Abstract

Provided is an ultra-large physical simulation facility for deep engineering disasters, including a long-time large-load loading system for a geological model, a 3D printing system of a deep oil, gas and water multiphase multi-component complex geological body model, a high-temperature-chemical-multiphase fluid collaborative injection, monitoring and control system, a robot excavation and monitoring system for a complex engineering structure in a model under deep geological environment, an intelligent ventilation system for a deep metal mine complex drilling, mining and transferring network, an intelligent filling system for a deep metal mine ultra-large stope, a deep-well enhanced geothermal safe intelligent mining system, an all-spatial-temporal intelligent high-precision monitoring system for an excavation and fracture process of a large-scale geological model, and an ultra-large multi-task intelligent collaborative main control and digital twin system for physical simulation tests.

IPC Classes  ?

• G01M 99/00 - Subject matter not provided for in other groups of this subclass
• E21F 17/00 - Methods or devices for use in mines or tunnels, not covered elsewhere

Goods & Services

Clothing, including, shirts; t-shirts; hats; toques, caps, scarves, bandanas, headbands; visors being headwear; sports jerseys; sweatshirts; hoodies; pants; shorts; socks; gloves; pullovers; jackets; tank tops; athletic tops; baby tops; bandeau tops; bikini tops; bra tops; crop tops; halter tops; knit tops; rugby tops; sweat tops; tennis tops; tube tops; underwear tops; vest tops; warm-up tops; woven tops; yoga tops; fleece tops; cloth bibs; sport bibs, bib overalls; bib shorts; bib tights; bibs for babies not of paper Paper goods and printed materials, including, stickers, decals, paper notebooks, printed notebooks, paper notepads, printed notepads, blank writing journals, pens and pencils, document portfolios; printed calendars; printed appointment planners Household goods, including beverage glassware; drinkware; mugs; tumblers for use as drinking bottles; non-electric portable coolers, coasters, bottle openers; insulated sleeve holders for bottles; and water bottles sold empty

Abstract

Provided herein are Ising tags for threshold sensing of a parameter of interest having a first parametric oscillator (PO), a second PO coupled to and power-combined with the first PO, and a sensor element for sensing a parameter of interest, the sensor element coupling the first and second POs.

IPC Classes  ?

• G02F 1/39 - Non-linear optics for parametric generation or amplification of light, infrared, or ultraviolet waves
• G01N 21/17 - Systems in which incident light is modified in accordance with the properties of the material investigated
• G01N 29/00 - Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic wavesVisualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
• H03B 17/00 - Generation of oscillations using a radiation source and a detector
• G01N 29/24 - Probes
• H01S 3/082 - Construction or shape of optical resonators or components thereof comprising three or more reflectors defining a plurality of resonators, e.g. for mode selection or suppression
• G01S 7/484 - Transmitters
• G01S 7/481 - Constructional features, e.g. arrangements of optical elements
• H01S 3/094 - Processes or apparatus for excitation, e.g. pumping using optical pumping by coherent light
• H03B 15/00 - Generation of oscillations using galvano-magnetic devices, e.g. Hall-effect devices, devices using spin transfer effects, devices using giant magnetoresistance, or using super-conductivity effects

Abstract

Described herein are photonic crystals comprising a plurality of substantially uniform zein particles. The photonic crystals can be fabricated by assembling the plurality of substantially uniform zein particles into one or more ordered and periodic structures that generate structural color. Also described herein are methods of using the photonic crystals described herein, e.g., as colorants in consumer products, such as food, drugs and/or cosmetics.

IPC Classes  ?

• G02B 1/00 - Optical elements characterised by the material of which they are madeOptical coatings for optical elements
• B82Y 20/00 - Nanooptics, e.g. quantum optics or photonic crystals
• C09B 19/00 - Oxazine dyes
• C09B 67/48 - Crystalline modifications of pigments or dyestuff
• G02B 1/118 - Anti-reflection coatings having sub-optical wavelength surface structures designed to provide an enhanced transmittance, e.g. moth-eye structures

Abstract

The present disclosure generally relates to methods of preparing nanocellulose, compositions comprising nanocellulose, methods of forming pulp-molded products, and devices for adhering sizing agents to compositions.

IPC Classes  ?

• C08B 15/00 - Preparation of other cellulose derivatives or modified cellulose
• C08L 1/02 - CelluloseModified cellulose
• D21C 5/00 - Other processes for obtaining cellulose, e.g. cooking cotton linters
• D21C 9/00 - After-treatment of cellulose pulp, e.g. of wood pulp, or cotton linters
• D21H 11/12 - Pulp from non-woody plants or crops, e.g. cotton, flax, straw or bagasse
• D21H 11/20 - Chemically or biochemically modified fibres
• D21H 17/17 - Ketenes, e.g. ketene dimers
• D21H 21/16 - Sizing or water-repelling agents

Abstract

The present invention directed to a novel macrocyclic depsipeptide compound, its derivatives, and their pharmaceutically acceptable salts, having selective antibacterial activity against M. tuberculosis.

IPC Classes  ?

• C07K 11/02 - Depsipeptides having up to 20 amino acids in a fully defined sequenceDerivatives thereof cyclic, e.g. valinomycins
• A01N 63/50 - Isolated enzymesIsolated proteins
• A61K 38/00 - Medicinal preparations containing peptides
• A61K 38/15 - DepsipeptidesDerivatives thereof
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 31/06 - Antibacterial agents for tuberculosis

Abstract

A MoS2@polyacrylonitrile-derived porous carbon fiber core-shell structure for use in all-solid-state lithium-sulfur batteries (ASSLSBs) is disclosed. The core-shell structure comprises a core comprising polyacrylonitrile-derived porous carbon fibers (PPCF) with surface layer pores; and a shell comprising a MoS2 nanosheet that is uniformly distributed on the surface of the core. Methods for making the core-shell structure are also disclosed, as well as methods of using the core-shell structure for ASSLSBs. The use of a MoS2@PPCF core-shell structure in an ASSLSB resulted in improved electrochemical performance with ultrahigh specific capacity, high cycling stability, and high-capacity retention.

IPC Classes  ?

• H01M 4/36 - Selection of substances as active materials, active masses, active liquids
• H01M 4/02 - Electrodes composed of, or comprising, active material
• H01M 4/58 - Selection of substances as active materials, active masses, active liquids of inorganic compounds other than oxides or hydroxides, e.g. sulfides, selenides, tellurides, halogenides or LiCoFySelection of substances as active materials, active masses, active liquids of polyanionic structures, e.g. phosphates, silicates or borates
• H01M 4/587 - Carbonaceous material, e.g. graphite-intercalation compounds or CFx for inserting or intercalating light metals
• H01M 10/0525 - Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodesLithium-ion batteries
• H01M 10/0562 - Solid materials

Abstract

Reduction in the tortuosity of electrodes is a favored strategy to enhance the fast-charging capability of lithium-ion batteries by optimizing the ion-transfer kinetics. A facile, low-cost, highly controllable, and high-output continual additive manufacturing roll-to-roll screen printing technology is disclosed herein to render customized vertical channels within electrodes. High-accuracy vertical channels were fabricated by applying as-developed inks, using LiNi0.6Mn0.2Co0.2O2, for example, as the cathode material. The optimized screen-printed electrode exhibited a seven-fold higher specific charge capacity (72 mAh/g) at a current rate of 6 C and superior stability compared with that of the conventional bar-coated electrode (10 mAh/g, 6 C) at a mass loading of 10 mg/cm2.

IPC Classes  ?

• H01M 4/04 - Processes of manufacture in general
• H01M 4/02 - Electrodes composed of, or comprising, active material
• H01M 4/131 - Electrodes based on mixed oxides or hydroxides, or on mixtures of oxides or hydroxides, e.g. LiCoOx
• H01M 4/1391 - Processes of manufacture of electrodes based on mixed oxides or hydroxides, or on mixtures of oxides or hydroxides, e.g. LiCoOx
• H01M 4/525 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of nickel, cobalt or iron of mixed oxides or hydroxides containing iron, cobalt or nickel for inserting or intercalating light metals, e.g. LiNiO2, LiCoO2 or LiCoOxFy

Abstract

A composition of an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate encapsulated in an oil-in-water nanoemulsion (NE) drug delivery system. A method of treating cancer by administering an effective amount of a pharmaceutical composition including a PUFA-taxoid conjugate encapsulated in an oil-in-water NE drug delivery system to a subject in need of treatment, and treating cancer. A method of overcoming multidrug resistance by exposing a multidrug resistant cell to an effective amount of a pharmaceutical composition including an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate encapsulated in an oil-in-water NE drug delivery system, and inducing the death of the multidrug resistant cell. A method of eliminating a cancer stem cell. Methods of reducing stemness of a cancer stem cell, retaining drug in the body, and providing a slower release profile.

IPC Classes  ?

• A61K 9/107 - Emulsions
• A61K 9/51 - Nanocapsules
• A61K 31/337 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
• A61K 47/12 - Carboxylic acidsSalts or anhydrides thereof
• A61K 47/44 - Oils, fats or waxes according to two or more groups of Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
• A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit

Abstract

A multiple-input-multiple-output (MIMO) radar system comprises two or more software-defined millimeter-wave (SDMMW) nodes, a host processing system that is electrically coupled to the two or more SDMMW nodes, and a MIMO aperture array coupled to the two or more SDMMW nodes. The MIMO radar system is configured to form a MIMO TX channel and a MIMO RX channel for each of the two or more SDMMW nodes. The MIMO radar system includes a millimeter wave (MMW) frequency-modulated continuous wave (FMCW) oscillator source configured to generate a MMW FMCW signal. For each of the two or more SDMMW nodes, the radar system includes an upconverter assembly and a downconverter assembly.

IPC Classes  ?

• G01S 13/48 - Indirect determination of position data using multiple beams at emission or reception
• G01S 13/89 - Radar or analogous systems, specially adapted for specific applications for mapping or imaging
• H04B 1/00 - Details of transmission systems, not covered by a single one of groups Details of transmission systems not characterised by the medium used for transmission
• H04B 7/0413 - MIMO systems

Abstract

Ligands that bind to and modulate (activate or deactivate) cannabinoid receptors having cannabinergic activity are described. These ligands are termed endocannabinoid analogs ("eCB analogs") because they possess structural similarities with the endogenously produced cannabinoids (or eCB lipids). The eCB analogs comprise advantageous and unique structural features when compared to currently known, naturally occurring eCBs, as well as synthetic eCB analogs.

IPC Classes  ?

• C07C 233/05 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
• C07C 233/09 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an acyclic unsaturated carbon skeleton
• A61K 31/164 - Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
• A61K 9/00 - Medicinal preparations characterised by special physical form

Abstract

Methods and devices for nanopore-based biomarker detection that utilize immunocapture, isothermal rolling circle amplification, and sequence-specific fragmentation of the product to release multiple DNA reporter molecules for nanopore detection. These DNA fragment reporters produce sets of nanopore signals that form distinctive fingerprints. This fingerprint signature therefore allows the identification and quantification of biomarker analytes.

IPC Classes  ?

• C12Q 1/682 - Signal amplification
• C12Q 1/6804 - Nucleic acid analysis using immunogens

Abstract

Embodiments define a method and apparatus for determining a geospatial location of an unlocated device communicatively coupled to a network while maintaining privacy. The unlocated device transmits a first encryption layer public enabling multiple other devices, including an assistant device, to employ the first encryption layer public key. The assistant device transmits a second encryption layer public key to the multiple other devices, and those devices return to the assistant device respective encrypted representations of geospatial locations encrypted by the first encryption layer public key and the second encryption layer public key. The assistant device decrypts the second layer encrypted representations of the geospatial locations with the second encryption layer secret key; and performs an averaging function on the representations of geospatial locations. The assistant device transmits the encrypted solution to the averaging function to the unlocated device, which decrypts the encrypted solution using the first encryption layer secret key.

IPC Classes  ?

• H04W 12/63 - Location-dependentProximity-dependent
• H04W 12/037 - Protecting confidentiality, e.g. by encryption of the control plane, e.g. signalling traffic

Abstract

Methods and systems are provided for analyzing the ability of immune cells to kill target cells based on the effectiveness of mitochondria of the immune cells. The systems and methods further can be used for transplanting healthy mitochondria into immune cells to increase their effectiveness against target cells. The methods described herein can be used in treatment of cancer, mitochondrial diseases, and certain metabolic diseases.

IPC Classes  ?

• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
• B01L 3/02 - BurettesPipettes
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• G01N 35/08 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• G01N 21/64 - FluorescencePhosphorescence

Abstract

A computer-implemented method and corresponding computer-based system detect sleep apnea. The computer-implemented method transforms electroencephalogram (EEG) data into features. The EEG data is produced from EEG signals output over a window of time while a patient is awake. The EEG signals are output by at least two EEG electrodes coupled to the patient. The computer-implemented method further detects sleep apnea in the patient by applying a prediction model to the features. The features represent electrodynamics of a brain of the patient as measured over the window of time via the at least two EEG electrodes while the patient is awake. Such a computer-implemented method and computer-based system obviate an overnight sleep study of the patient in order to diagnose the patient as having sleep apnea.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

Microfluidic devices for use with reagents bound to microspheres for determination of the concentration of an analyte in a liquid sample are provided. The devices include two sequential mixing channels that promote rapid binding of microsphere-bound reagents with reagents in solution and a means for detecting labeled microsphere-bound reaction products. Also provided are methods for using the devices with microsphere-bound reagents to determine the concentration of an analyte in a liquid sample and to measure the binding affinity of antibody for an antigen.

IPC Classes  ?

• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• B01F 25/433 - Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
• B01F 33/30 - Micromixers
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• G01N 21/64 - FluorescencePhosphorescence
• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor

Abstract

Systems and methods are provided for selecting a beam direction of mm wave transmission for use by a vehicle operating within a network environment. The systems and methods include collecting data from a plurality of sensors on the vehicle to detect obstructions and other changes to an environment of the vehicle and of a base station that communicates with the vehicle. The systems and methods further include a library of digital twins, which are a virtual representation of the real-world environment, to identify beam directions of varying signal-to-noise ratios. The systems and methods further include determining from the data collected from the plurality of sensors a preferred digital twin and using the beam direction data corresponding to the digital twin to determine a beam direction for a transmitter of the vehicle to communicate with a receiver of the base station.

IPC Classes  ?

• B60W 60/00 - Drive control systems specially adapted for autonomous road vehicles
• H04W 4/44 - Services specially adapted for particular environments, situations or purposes for vehicles, e.g. vehicle-to-pedestrians [V2P] for communication between vehicles and infrastructures, e.g. vehicle-to-cloud [V2C] or vehicle-to-home [V2H]

Abstract

A computer-based system and corresponding computer-implemented method for validating a black-box model are provided. An initial question is transformed into at least one additional question by rephrasing the initial question based on an initial answer from the black-box model to the initial question. A consistency metric is produced based on consistency of the initial answer and respective additional answers received from the black-box model in response to the at least one additional question. The black-box model is validated based on the consistency metric produced.

IPC Classes  ?

• G06F 30/20 - Design optimisation, verification or simulation

Abstract

Physical identification tags are provided that contain patterns of magnetized and non-magnetized nanoparticles embedded in a matrix. The magnetic nanoparticles form a spatially unique magnetic field distribution that is detectable only with the use of a quantum scanning magnetometer with nanometer resolution. The invisible magnetic field pattern is randomly generated by the mixture of magnetic with nonmagnetic nanoparticles and is physically impossible to reproduce. The tags can be used for identification and authentication of articles of commerce, artworks, and subjects.

IPC Classes  ?

• G01R 33/02 - Measuring direction or magnitude of magnetic fields or magnetic flux
• G01R 33/12 - Measuring magnetic properties of articles or specimens of solids or fluids
• G01R 33/32 - Excitation or detection systems, e.g. using radiofrequency signals
• C09C 1/62 - Metallic pigments or fillers
• C09D 5/23 - Magnetisable or magnetic paints or lacquers
• C09D 7/62 - Additives non-macromolecular inorganic modified by treatment with other compounds
• B42D 25/369 - Magnetised or magnetisable materials
• B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites

Abstract

Provided herein are methods and systems for beyond line of sight control of autonomous vehicles including a wireless network having an Open RAN infrastructure in communication with a core network and a MEC infrastructure, a MEC orchestrator deployed in the Open RAN infrastructure and including MEC computing nodes and a ground control station, a catalog in communication with the orchestrator and including MEC function apps for operating the MEC infrastructure and/or the core network, and Open RAN apps for operating the Open RAN infrastructure, wherein the orchestrator is configured to process data from the MEC infrastructure, the core network, the open RAN infrastructure, or combinations thereof, and instantiate the MEC function apps in the MEC infrastructure and/or core network, instantiate the Open RAN apps in the Open RAN infrastructure, or combinations thereof to manage a plurality of vehicle functions and/or wireless network functions responsive to data from the vehicles.

IPC Classes  ?

• H04W 88/12 - Access point controller devices
• G05D 1/226 - Communication links with the remote-control arrangements
• H04L 41/16 - Arrangements for maintenance, administration or management of data switching networks, e.g. of packet switching networks using machine learning or artificial intelligence
• H04W 24/10 - Scheduling measurement reports
• H04W 28/084 - Load balancing or load distribution among network function virtualisation [NFV] entitiesLoad balancing or load distribution among edge computing entities, e.g. multi-access edge computing

Abstract

Scaffolds, including Nerve Guidance Scaffolds (NGSs), and methods of making and using scaffolds are provided. In some embodiments, an NGS is used for the connecting damaged nerves together through surgical repair, optionally aided by expression of proteins from adeno-associated viral (AAV) vectors. In some embodiments, NGSs bridge two or more nerve endings to fix damaged nerves using a singular scaffold; methods of making the NGSs are also provided.

IPC Classes  ?

• A61L 27/20 - Polysaccharides
• A61L 27/24 - Collagen
• A61L 27/54 - Biologically active materials, e.g. therapeutic substances
• A61L 27/56 - Porous or cellular materials
• A61L 31/04 - Macromolecular materials
• A61L 31/14 - Materials characterised by their function or physical properties
• A61L 31/16 - Biologically active materials, e.g. therapeutic substances
• A61L 27/50 - Materials characterised by their function or physical properties

Abstract

Provided herein are methods and systems for sharing spectrum, computing resources. and Radio Access Network (RAN) elements in a wireless communication network, the system including a centralized service management and orchestration (SMO) entity, the SMO including an optimization engine for determining one or more resource allocation policies responsive to one or more received tenant requests and based on network state information received from a radio access network (RAN) and deploying the determined resource allocation policies on the network, a plurality of edge datacenters configured to instantiate virtualized networking services in response to the deployed resource allocation policies from the optimization engine, and a plurality of cell sites, the cell sites operating the network in response to instructions from the edge datacenters consistent with the deployed resource allocation policies.

IPC Classes  ?

• H04W 16/14 - Spectrum sharing arrangements
• H04W 24/02 - Arrangements for optimising operational condition

Abstract

Melamine Formaldehyde (MF) photonic cooling bulk is disclosed for covering outer surfaces of a building. The MF photonic cooling bulk comprises a mass of hydraulically pressed MF microparticles that has been thermally annealed to form a fire and corrosion-resistant, cross-linked photonic cooling bulk configured to reflect incident solar irradiation and radiate heat from the building to the outer space.

IPC Classes  ?

• C08J 9/24 - Working-up of macromolecular substances to porous or cellular articles or materialsAfter-treatment thereof by surface fusion and bonding of particles to form voids, e.g. sintering
• C09K 5/14 - Solid materials, e.g. powdery or granular
• C09K 21/14 - Macromolecular materials

Abstract

Provided herein are open radio access network (Open RAN) adapters for using non-open RAN nodes in a wireless network having Open RAN infrastructure, the Open RAN adapters including one or more control application programming interfaces (Control APIs) for controlling the non-open RAN nodes, one or more Data Capture APIs for capturing operational data from the non-open RAN nodes, one or more Open RAN interfaces for communication between the Open RAN adapter and the Open RAN infrastructure and one or more software modules each configured to translate data received via the Data Capture APIs to Open RAN compatible data for use by the Open RAN infrastructure and/or translate Open RAN commands received via the Open RAN interfaces to non-open RAN compatible commands for instantiation at one or more of the non-open RAN nodes via the Control APIs.

IPC Classes  ?

• H04L 41/5009 - Determining service level performance parameters or violations of service level contracts, e.g. violations of agreed response time or mean time between failures [MTBF]
• H04L 41/06 - Management of faults, events, alarms or notifications

Abstract

A screen-printable electrode battery ink is described comprising a slurry of an active ingredient, conductive additive, a binder, and a solvent, the slurry having a solids content from about 40% by weight to about 70% by weight that is uniformly distributed in the solvent, wherein the ink has a thixotropic recovery rate from about 30 seconds to about 90 seconds, and wherein the binder has untwisted molecular chains. Methods for making the screen-printable electrode battery ink are also described. The screen-printable electrode battery inks can be used to screen print electrodes, for use in fast-charging battery. Fast-charging batteries can be incorporated into electronic devices, such as electric vehicles.

IPC Classes  ?

• H01M 4/04 - Processes of manufacture in general
• H01M 4/505 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of manganese of mixed oxides or hydroxides containing manganese for inserting or intercalating light metals, e.g. LiMn2O4 or LiMn2OxFy
• H01M 4/525 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of nickel, cobalt or iron of mixed oxides or hydroxides containing iron, cobalt or nickel for inserting or intercalating light metals, e.g. LiNiO2, LiCoO2 or LiCoOxFy
• H01M 4/62 - Selection of inactive substances as ingredients for active masses, e.g. binders, fillers

Abstract

Disclosed are a system and an in vivo assay for the physiological evaluation of water-soluble general anesthetics. The assay is based on the effects of anesthetics on the frequency of the pacemaker nucleus, an endogenous neural oscillator in the brainstem, of the weakly electric fish Apteronotus leptorhynchus.

IPC Classes  ?

• A61K 49/00 - Preparations for testing in vivo

Abstract

The disclosure provides methods of forming one or more single-cell proteomic samples, such as by: dispensing n droplets of lysis buffer onto a substantially planar solid surface, wherein n>2: dispensing a single cell into each of the n droplets of lysis buffer to produce n droplets with a lysed single cell: dispensing digestion buffer into each of the n droplets to digest proteins from each lysed single cell to produce n droplets comprising peptides: dispensing a chemical tag into at least a subset of the n droplets comprising the peptides to produce labeled peptides, thereby enabling the labeled peptides in a given droplet to be distinguishable from labeled peptides in at least one other droplet: and applying a fluid to merge at least a subset of the droplets into a combined droplet on the substantially planar surface, thereby combining the labeled peptides to form a single-cell proteomic sample.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• G01N 1/34 - PurifyingCleaning

Abstract

The present technology provides straightforward, reproducible, scalable, and efficient multimode chromatography-based methods for the effective isolation and/or purification of nanoparticulate biomaterials from mixtures of biomaterials. The methods can be used to isolate and purify extracellular vesicles and other nanoparticulate biomaterials from plasma and other sources to provide high purity products. The methods can be used to diagnose medical conditions and to prepare pharmaceutical products.

IPC Classes  ?

• B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
• B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Abstract

An integrated platform is provided for direct and unbiased label-free native analysis of N-glycans from single cells and biological samples as small as 1 nL or less. An in-capillary sample processing method is coupled with high-sensitivity label-free capillary electrophoresis and mass spectrometry. Direct, label-free characterization and quantification of single-cell surface N-glycomes can be performed with the detection of up to 100 N-glycans per single cell and up to 400 N-glycans per nL of blood. N-glycome alterations can be detected at the single-cell level for diagnosis of medical conditions. The platform also preserves cell integrity and therefore can be used for spatial glycomic and multiomic profiling at the single cell level.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• G01N 27/447 - Systems using electrophoresis

Abstract

A framework for joint computation, caching, and request forwarding in data-centric computing-based networks comprises a virtual control plane, which operates on request counters for computations and data, and an actual plane, which handles computation requests, data requests, data objects and computation results in the physical network. A throughput optimal policy, implemented in the virtual plane, provides a basis for adaptive and distributed computation, caching, and request forwarding in the actual plane. The framework provides superior performance in terms of request satisfaction delay as compared with several baseline policies over multiple network topologies.

IPC Classes  ?

• H04L 41/082 - Configuration setting characterised by the conditions triggering a change of settings the condition being updates or upgrades of network functionality
• G06F 9/54 - Interprogram communication
• H04L 67/10 - Protocols in which an application is distributed across nodes in the network
• H04L 67/568 - Storing data temporarily at an intermediate stage, e.g. caching
• H04L 69/00 - Network arrangements, protocols or services independent of the application payload and not provided for in the other groups of this subclass

Abstract

Provided herein are systems for controlling a network of distributed non-terrestrial nodes including a control framework operative to train and control a plurality of the non-terrestrial nodes, the control framework including a control interface in communication with a network operator to receive one or more specified control objectives, and a learning engine operative to train a virtual non-terrestrial network, wherein the control framework is further operative to transfer knowledge gained through the training of the virtual non-terrestrial network to the network of distributed non-terrestrial nodes as data-driven logic unit configurations tailored for the specified control objectives.

IPC Classes  ?

• H04L 41/122 - Discovery or management of network topologies of virtualised topologies e.g. software-defined networks [SDN] or network function virtualisation [NFV]
• H04W 84/06 - Airborne or Satellite Networks

Abstract

Selective small molecule regulators of GIRK potassium channels are provided, which are effective in treatment of post-traumatic stress disorder and other medical conditions.

IPC Classes  ?

• C07D 409/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
• A61K 31/415 - 1,2-Diazoles
• A61P 25/22 - Anxiolytics
• C07D 231/40 - Acylated on said nitrogen atom
• C07D 401/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 403/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 405/12 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 413/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 417/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

In accordance with one aspect of the disclosure, a system including a plurality of pedicle screws configured to engage a spine of a patient and each including an electrode, a power source coupled to the pedicle screws and configured to provide an electrical current to each electrode, and a controller is provided. The controller is configured to selectively supply power to the pedicle screws to cause a first electrical stimulation to be output in a first direction from a first pedicle screw to a second pedicle screw, and cause a second, electrical stimulation to be output in a second direction from the second pedicle screw to the first pedicle screw.

IPC Classes  ?

• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
• A61B 17/86 - Pins or screws
• A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
• A61N 1/375 - Constructional arrangements, e.g. casings
• A61N 1/378 - Electrical supply

Abstract

Methods are provided for estimating a pose of an infant using image analysis and artificial intelligence. A classifier is trained using a dataset containing hybrid synthetic and real infant pose data. Multi-stage invariant representation machine learning strategies are employed that transfer knowledge from adjacent domains of adult poses and synthetic infant images into a fine-tuned domain-adapted infant pose estimation model.

IPC Classes  ?

• G06T 7/73 - Determining position or orientation of objects or cameras using feature-based methods
• G06T 15/04 - Texture mapping

Abstract

Methods for making a site-specific modification of a glycoprotein are provided which preserve the charge and glycoform of the glycoprotein. One or more glycans are trimmed from the glycoprotein, while keeping a core glycan attached to the glycoprotein. The removal of the one or more glycans provides access to a targeted amino acid for a site-specific reaction. The attached core glycan can optionally be utilized for modulation of the glycoprotein, or one or more glycans or reagents can be attached to the core.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• C07K 1/107 - General processes for the preparation of peptides by chemical modification of precursor peptides
• C12N 9/10 - Transferases (2.)
• C12N 9/24 - Hydrolases (3.) acting on glycosyl compounds (3.2)

Abstract

Subjects and their activities are identified via a wireless network. A wireless transmitter device transmit a wireless signal through the environment, and a plurality of wireless receivers receive the wireless signal at a distinct location within the environment, and then generate a channel state information (CSI) packet indicating a state of a wireless communications channel associated with the wireless signal. A computing device processes the CSI packets from the plurality of wireless receivers to generate a CSI dataset as a function of the CSI packets. A subject classifier identifies a target subject of the plurality of subjects based on the CSI dataset via a subject machine learning (ML) model. An activity classifier identifies an activity exhibited by the target subject based on the CSI dataset via an activity ML model trained on a training dataset.

IPC Classes  ?

• H04W 64/00 - Locating users or terminals for network management purposes, e.g. mobility management
• H04B 7/06 - Diversity systemsMulti-antenna systems, i.e. transmission or reception using multiple antennas using two or more spaced independent antennas at the transmitting station

Abstract

The disclosed systems and methods provide a systematic approach to analyzing an individual's lifestyle factors (e.g., foods consumed by the individual) that contribute to the individual's current or potential for disease, and taking further action based on that analysis. One example embodiment is a machine learning system that includes a food composition layer, chemical compounds layer, and disease layer. The food composition layer provides representations of chemical compounds of foods consumed or to be consumed by the individual. The chemical compounds layer is coupled to the food composition layer by links and filters the representations of the chemical compounds based on genetic or metabolic information of the individual, resulting in representations of personalized filtered chemical compounds. The disease layer is coupled to the chemical compounds layer by links and associates a representation of a disease with representations of the personalized filtered chemical compounds based on a disease module for the disease.

IPC Classes  ?

• G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
• G06N 20/00 - Machine learning
• G16H 20/60 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to nutrition control, e.g. diets
• G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
• G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients

Abstract

Provided herein are acoustic material (AM) CMRs having an active region including a conductive plate suspended over a cavity in a substrate and anchored to the substrate by two y-anchors, a piezoelectric layer disposed on the conductive plate, and an interdigitated metal structure (IDT) to cause transduction for excitement of a longitudinal mode of vibration of the AM CMR; and a pair of AM reflectors (AMRs) forming lateral anchors anchored to the substrate and attached to opposite sides of the conductive plate along the direction of vibration of the AM CMR, the AMRs each including a conductive anchor plate suspended over the cavity in the substrate, and a piezoelectric layer disposed on the conductive plate, and a parallel array of rods disposed on the piezoelectric layer, wherein the AMRs are configured to generate an acoustic stopband for inhibiting lateral leakage of the excited longitudinal mode of vibration.

IPC Classes  ?

• H03H 9/145 - Driving means, e.g. electrodes, coils for networks using surface acoustic waves
• H03H 3/08 - Apparatus or processes specially adapted for the manufacture of impedance networks, resonating circuits, resonators for the manufacture of electromechanical resonators or networks for the manufacture of resonators or networks using surface acoustic waves
• H03H 9/02 - Networks comprising electromechanical or electro-acoustic elementsElectromechanical resonators Details
• H03H 9/25 - Constructional features of resonators using surface acoustic waves

Abstract

The disclosure herein provides, in example embodiments, a copper-catalyzed azide¬ alkyne cycloaddition (CuAAC)-accelerating ligand, methods of synthesizing the ligand, and methods of performing CuAAC with the ligand, e.g., methods of labeling biomolecules with CuAAC using the ligand.

IPC Classes  ?

• C07H 21/00 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
• C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay

Abstract

Embodiments disclose a fluidic device. Said device has first and second layers that are configured to be coupled together via magnetic attraction to form a cavity. An embodiment defines an apical layer and a basal layer and a membrane therebetween within the cavity. Another embodiment of the fluidic device comprises a port positioned in optical arrangement with the internal cavity for optical observation of fluids or activities therein. These embodiments provide improvements to organ-on-chip (OoC) scalability, assembly and disassembly as well as cell observation with low disturbance to the culture inside the cavity.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• G01N 21/03 - Cuvette constructions
• C12M 3/06 - Tissue, human, animal or plant cell, or virus culture apparatus with filtration, ultrafiltration, inverse osmosis or dialysis means

Abstract

Disclosed herein is a double-layer ion-selective membrane, method of production, applications of the double-layer ion-selective membrane as a redox flow cell, a fuel cell, and used for wastewater and air purification. The double-layer ion-selective membrane is comprised of a polyetherimide (PEI) layer and an ultrathin layer comprising porous boron nitride (PBN) flakes enmeshed by a NAFION™ resin. The double layer membrane exhibits ion-selectivity and ion-conductivity enabling the membrane to be used in a redox flow cell battery, a fuel cell battery, and to be used in wastewater and air purification applications.

IPC Classes  ?

• B01D 69/12 - Composite membranesUltra-thin membranes
• B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
• B01D 71/02 - Inorganic material
• B01D 71/64 - PolyimidesPolyamide-imidesPolyester-imidesPolyamide acids or similar polyimide precursors

Abstract

Provided herein are Ising machines having a resonant input mesh driven by a pump signal, a resonant output mesh coupled to the input mesh through a nonlinear component to form a parametric frequency divider (PFD), and the nonlinear component configured to passively activate, responsive to the pump signal exceeding a threshold power, a parametric oscillation between the input and output meshes having an oscillation frequency equal to half an angular input frequency of the pump signal, wherein an output signal of the PFD can be switched between an in-phase state and an out-of-phase state.

IPC Classes  ?

• H03K 5/00 - Manipulation of pulses not covered by one of the other main groups of this subclass
• H03K 17/92 - Electronic switching or gating, i.e. not by contact-making and -breaking characterised by the use of specified components by the use, as active elements, of superconductive devices
• H03K 21/08 - Output circuits

Abstract

A method of detecting auditory attention in a multiple speaker includes collecting a number of EEG signals while a listener is listening to a first sound source and a second sound source, creating a concatenated signal by concatenating together the EEG signals, a first speech envelope signal based on the first sound source and a second speech envelope signal based on the second sound source, providing the concatenated signal to a trained CNN that outputs a normalized convolution layer output, converting the normalized convolution layer output into a plurality of event based spikes, and providing the plurality of event based spikes to a trained SNN, wherein the SNN processes the plurality of event based spikes and classifies only one of the first sound source and the second sound source as an attended sound source of the listener.

IPC Classes  ?

• G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer
• G06N 3/02 - Neural networks
• A61B 5/369 - Electroencephalography [EEG]
• G06F 18/25 - Fusion techniques
• A61B 5/12 - Audiometering
• G06N 3/08 - Learning methods