Provided herein are systems for a wireless, battery-free acoustic sensor having a subharmonic tag (SubHT) and an acoustic transducer, wherein the acoustic transducer is integrated with the SubHT, such that an acoustic signal received by the acoustic transducer modulates an electrical output of the SubHT when the SubHT is interrogated by a radiofrequency input signal of a reader device, resulting in conversion of the acoustic signal into information transmitted by the sensor via a radiofrequency output signal without the use of battery power.
G01H 11/08 - Measuring mechanical vibrations or ultrasonic, sonic or infrasonic waves by detecting changes in electric or magnetic properties by electric means using piezoelectric devices
H01Q 1/22 - SupportsMounting means by structural association with other equipment or articles
Subharmonic tags for passive far-field sensing are provided having at least one antenna configured to receive an interrogation signal having a plurality of interrogation frequencies, a passive LTI network in electrical communication with the at least one antenna, and two or more resonators, each resonator having a different resonant frequency and a corresponding trigger frequency different than the resonant frequency, wherein the passive LTI network is configured such that the tag only produces a response signal for trigger frequencies that are different from any of the resonant frequencies of the resonators, each resonator of the subharmonic tag configured to produce a response signal having a different frequency than the trigger frequency, the subharmonic tag configured to produce an output signal responding to the interrogation signal, the output signal including one or more of the response signals.
G06K 19/07 - Record carriers with conductive marks, printed circuits or semiconductor circuit elements, e.g. credit or identity cards with integrated circuit chips
Provided herein are methods and systems for quasi-harmonic tags (qHT) including an electromagnetic resonator, an input mesh including an input notch filter having a resonant frequency of ωinput, an output mesh including an output notch filter having a resonant frequency of ωoutput; and an antenna, wherein the qHT is configured to emit a comb output signal responsive to an input signal having an input frequency (op twice a resonance frequency of at least one of the electromagnetic resonators.
G01S 5/02 - Position-fixing by co-ordinating two or more direction or position-line determinationsPosition-fixing by co-ordinating two or more distance determinations using radio waves
G01S 5/14 - Determining absolute distances from a plurality of spaced points of known location
G06K 19/07 - Record carriers with conductive marks, printed circuits or semiconductor circuit elements, e.g. credit or identity cards with integrated circuit chips
4.
Methods for Detecting, Evaluating, and Mitigating Conflicts in Open RAN Systems
Provided herein are methods and systems for detecting, evaluating, and mitigating conflicts in an open radio access network (open RAN) including a profiler for generating an application profile for each of a plurality of applications deployable on the open RAN by simulating a behavior of each application with respect to a corresponding parameter set under a predefined plurality of operational condition sets, a conflict detection component configured to determine a predicted existence of a conflict between a requested application and one or more currently instantiated applications, a conflict evaluation component configured to determine a predicted frequency and a predicted severity of the conflict, and a conflict mitigation component configured to develop a conflict mitigation scheme and, according to the conflict mitigation scheme, at least one of block instantiation of the requested application, instantiate the requested application, or uninstantiate at least one of the currently instantiated applications.
H04L 41/0873 - Checking configuration conflicts between network elements
H04L 41/5009 - Determining service level performance parameters or violations of service level contracts, e.g. violations of agreed response time or mean time between failures [MTBF]
5.
Microfluidic Device with On-Demand Droplet Trapping and Release for Single Cell Analysis
Microfluidic devices and methods are provided for single-cell analysis, isolation, and preparation for immunotherapy. The technology allows functional phenotyping by observing cell-cell interactions and then cells with desirable features or probing the underlying biology. A droplet-based microfluidic device is capable of trapping droplets and releasing them selectively using microvalves. Each droplet can encapsulate effector cells, such as natural killer cells (NK cells) and target cells, such as tumor cells, for real-time monitoring of burst kinetics and spatial coordination during killing of tumor cells by individual NK cells. The technology also allows for interrogating interactions and real-time monitoring of kinetics and then recovering live cells on demand for single-cell genomic or proteomic analysis.
A wireless communications network transmits beamformed signals via compressed beamforming feedback. A transmitter generates beamformed signals and omnidirectional signals. A receiver, communicatively coupled to the transmitter via a wireless channel, generates channel state information (CSI) based on a received signal from the transmitter; generates, via a first neural network (NN), a compressed representation of beamforming feedback as a function of the CSI; and transmits the compressed representation to the transmitter via the wireless channel. The transmitter then determines, via a second NN, the beamforming matrix as a function of the compressed representation; and generates a subsequent beamformed signal toward the receiver as a function of the beamforming matrix.
Achieving high energy density and fast charging of lithium-ion batteries can accelerate the adoption of electric vehicles. However, the increased mass and poor charge transfer properties of existing electrodes impede the electrochemical reaction kinetics and limit the battery charging speed. Herein is demonstrated a novel stamping process to create channels in electrode material that accelerate ion transport and increase rate performance of the electrode. Pressure applied during the stamping process improved the mechanical stability of the electrode and its contact with the current collector. The stamped low-tortuosity LiFePO4 electrode demonstrated a higher discharge capacity compared to a conventional electrode with the same thickness of 155 μm at high rate (101 mAh/g and 16 mAh/g, respectively, at a rate of 3 C) and superior stability. The stamping method offers unparalleled possibilities for industrial applications, owing to its simplicity, scalability, low cost and solvent consumption, and waste reduction.
H01M 4/58 - Selection of substances as active materials, active masses, active liquids of inorganic compounds other than oxides or hydroxides, e.g. sulfides, selenides, tellurides, halogenides or LiCoFySelection of substances as active materials, active masses, active liquids of polyanionic structures, e.g. phosphates, silicates or borates
H01M 4/02 - Electrodes composed of, or comprising, active material
Provided herein are methods of labeling nuclear RNA, including methods comprising: (a) isolating a nucleus of a cell, the nucleus comprising nuclear RNA; (b) contacting the nucleus with a fixative, thereby producing a fixed nucleus; (c) contacting the fixed nucleus with a surfactant; and (d) hybridizing a primary probe to the nuclear RNA, thereby forming a primary sample comprising labeled nuclear RNA.
A bipedal robot having a legged assembly and an aerial assembly is described. The legged assembly includes two legs, each leg having a hip frontal joint, a hip sagittal joint, and a knee joint. The aerial assembly includes two thrusters mounted on a carbon fiber-aluminum composite mount. Actuators for the joints include 3D printed housings with embedded components. A controller generates walking trajectories and controls the thrusters to assist with stabilization and obstacle traversal. The robot is capable of dynamic multimodal locomotion, combining legged movement with thruster-assisted stabilization and jumping to navigate challenging terrain.
B60F 5/02 - Other vehicles capable of travelling in or on different media convertible into aircraft
B62D 57/032 - Vehicles characterised by having other propulsion or other ground-engaging means than wheels or endless track, alone or in addition to wheels or endless track with ground-engaging propulsion means, e.g. walking members with alternately or sequentially lifted supporting base and legVehicles characterised by having other propulsion or other ground-engaging means than wheels or endless track, alone or in addition to wheels or endless track with ground-engaging propulsion means, e.g. walking members with alternately or sequentially lifted feet or skid
A system for generating design concepts includes a generative adversarial network (GAN) with a generator, a plurality of inspectors evaluating generated samples based on respective criteria, and a processor executing instructions. The processor generates design samples using the GAN generator, evaluates the generated samples using the plurality of inspectors, and adjusts parameters of the GAN based on feedback from the plurality of inspectors to produce diverse and novel design concepts. The plurality of inspectors may include a novelty inspector, a diversity inspector, and a desirability inspector. The system enables the generation of design concepts that are both innovative and aligned with user preferences.
Systems and methods for determining properties of an object are disclosed. A system includes a gripping element and at least one waveguide coupled to the gripping element. The waveguide is configured to transport a light signal through the gripping element and to transmit the light signal, at least a portion of the light signal illuminating the object. A detector is configured to detect at least a portion of the light signal and sense a curvature of the gripping element. A probe element coupled to the gripping element is configured to collect light reflected from the object. A spectrometer is configured to generate spectral data using the reflected light collected. A processor is configured to calibrate the spectral data based on the curvature and to determine properties of the object based on the curvature and the spectral data. The system enables recognition and profiling of objects based on spectroscopy and curvature.
G01N 21/27 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection
G01B 11/255 - Measuring arrangements characterised by the use of optical techniques for measuring contours or curvatures for measuring radius of curvature
G01N 21/25 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
12.
High Capacity, Shallow Draft, Ocean-Borne Wind Turbine
A high capacity, shallow draft, ocean-borne wind turbine is described, featuring a floating structure with at least three floats and a turbine rotor coupled to a generator with a power capacity of at least 3 MW. The turbine includes multiple blades, each with a length, and an operational draft less than about one-sixth of the blade length. Variations include configurations with round surface piercing floats and specific arrangements of four floats in a square formation. The design ensures a draft in operation of less than 1 meter per MW of rated capacity, providing an efficient and stable platform for offshore wind energy generation.
Provided are engineered living materials including engineered fibers and engineered microbial cells. The engineered fibers include a first Curli protein fused to a first binding peptide and a second Curli protein fused to a second binding peptide, wherein the first binding peptide is covalently linked to the second binding peptide, crosslinking the first Curli protein with the second Curli protein.
A system for calorimetry includes a plurality of wells disposed upon a well plate, an input feature to deposit a sample within each well, and light sources configurable to irradiate each of the wells in the well plate, and their samples, with incident light. A photonic sensor chip at a bottom of each well includes a plural nanohole array sensor on a substrate. A light detector positioned below the well is configured to measure the transmission of light through the sensors, obtaining a series of optical transmission measurements. A heater is in thermal contact with each of the wells, applying a transient thermal increase to each well, and the sample therein, at a known heat rate. A processor is configured to calculate a measurement for each well as a function of the series of optical transmission measurements and the transient thermal increase, the measurement being indicative of the sample within the well undergoing a change in response to the transient thermal increase, the change relating to a property of the sample.
Systems, methods, and computer program products for training models to generate images are described herein. The method may comprise providing an input vector of a latent space of the generative model to a generator of a generative model; reading at least one sample generated by the generator based on the input vector; providing the at least one sample and at least one corresponding example to a plurality of inspectors of the generative model; reading vectors generated by the plurality of inspectors; determining a generator loss value characterizing performance of the generator based on the vectors generated by the plurality of inspectors; and training the generator based on the generator loss value.
Provided herein are, in various embodiments, methods and kits for assaying one or more virions. In certain embodiments, the methods and kits of the disclosure provide for the calculation of virion titer and/or virion infectivity. In still further embodiments, the disclosure provides for methods and kits for enhancing assaying of viruses such as SARS-CoV-2.
A shelter including a support frame (15). A flexible exterior shelter layer (32) can cover the support frame. The exterior shelter layer can form exterior shelter layer roof and sidewall portions of the shelter. A flexible waterproof floor (22) can be included having a floor bottom portion and a floor sidewall portion. The floor sidewall portion can extend upwardly above the floor bottom portion. The floor sidewall portion can be removably securable to the exterior shelter layer sidewall portion above the floor bottom portion.
Provided herein are, in various embodiments, methods and compositions for treating muscular dystrophy in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a composition comprising a bottlebrush polymer-oligonucleotide conjugate. Also provided herein are methods of making bottlebrush polymer-oligonucleotide conjugates.
The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization (Israel)
Northeastern University (USA)
Inventor
Shemesh, Moshe
Lima Angelini, Leticia Mara
Chai, Yunrong
Abstract
A composition of matter comprising genetically modified bacteria of the Bacillus genus which over-express cyclodipeptide synthase (YvmC) and/or cytochrome P450 oxidase (CypX) is disclosed. The bacteria synthesize at least twice the amount of pulcherriminic acid as compared to the amount synthesized in a non-genetically modified bacteria of a corresponding strain.
Described herein is an all-solid-state battery comprising two or more mono cells connected in series, wherein: each mono cell comprises a lithium-based cathode, a sulfide solid electrolyte, and an anode; and adjacent mono cells are connected through a single, shared current collector in contact with a cathode and an anode of adjacent mono cells. The all-solid-state battery can be fabricated by stacking freestanding layers of the lithium-based cathode, the sulfide solid electrolyte, the anode, and the current collector in a bipolar design, and pressing the layers together to form the all-solid-state battery. The lithium-ion battery -can be incorporated into portable electronics and electric vehicles.
H01M 4/134 - Electrodes based on metals, Si or alloys
H01M 4/1391 - Processes of manufacture of electrodes based on mixed oxides or hydroxides, or on mixtures of oxides or hydroxides, e.g. LiCoOx
H01M 4/36 - Selection of substances as active materials, active masses, active liquids
H01M 4/38 - Selection of substances as active materials, active masses, active liquids of elements or alloys
H01M 4/525 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of nickel, cobalt or iron of mixed oxides or hydroxides containing iron, cobalt or nickel for inserting or intercalating light metals, e.g. LiNiO2, LiCoO2 or LiCoOxFy
H01M 4/62 - Selection of inactive substances as ingredients for active masses, e.g. binders, fillers
H01M 10/0585 - Construction or manufacture of accumulators having only flat construction elements, i.e. flat positive electrodes, flat negative electrodes and flat separators
21.
AN OLIGONUCLEOTIDE-BASED STRATEGY FOR CAPTURE, DETECTION, ADAPTATION, AND SEQUENCING OF TRNA USING NANOPORE TECHNOLOGY
Disclosed are methods of preparing a sequencing library to quantify tRNA abundance and tRNA modifications in an RNA sample that comprises contacting RNA with oligonucleotides in the presence of a ligating agent and performing nanopore direct sequencing. It also discloses a kit to perform said method.
C12Q 1/6874 - Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation [SBH]
C12Q 1/25 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving enzymes not classifiable in groups
Provided herein are hexavalent, fully-functionalized benzene derivatives comprising two types of functional groups, wherein each functional group type alternates around the benzene ring, so no identical functional groups are positioned next to one another. In certain embodiments, the first functional group is selected from an aldehyde (CO), imine (CNH), or iminium, and the second functional group is selected from a primary amine (NH2) or ammonium (NH3+). The hexavalent, fully-functionalized benzene derivatives of the invention as useful as monomers in the formation of planar, two-dimensional polymer networks. Also provided are covalent organic frameworks comprising the hexavalent, fully-functionalized benzene derivatives of the invention. Also provided herein are synthetic fibers comprising such two-dimensional polymers. Further provided are methods of making the hexavalent, fully-functionalized benzene derivatives.
C08G 69/32 - Polyamides derived from amino carboxylic acids or from polyamines and polycarboxylic acids derived from polyamines and polycarboxylic acids from aromatic diamines and aromatic dicarboxylic acids with both amino and carboxylic groups aromatically bound
C07C 225/22 - Compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly-bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
Disclosed are polymers, methods of making polymers, and compositions, focused on cross-linking heterocycles comprising a moiety of Formula I with thiols and thiolates.
A61K 8/49 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
A61K 8/58 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
A61K 8/65 - CollagenGelatinKeratinDerivatives or degradation products thereof
A61K 47/22 - Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
C08F 283/06 - Macromolecular compounds obtained by polymerising monomers on to polymers provided for in subclass on to polyethers, polyoxymethylenes or polyacetals
C08F 289/00 - Macromolecular compounds obtained by polymerising monomers on to macromolecular compounds not provided for in groups
C08G 75/06 - Polythioethers from cyclic thioethers
C09D 1/00 - Coating compositions, e.g. paints, varnishes or lacquers, based on inorganic substances
Provided herein are, in various embodiments, methods and compositions comprising polyethylene glycol (PEG)-conjugated oligonucleotides (e.g., anti-sense oligonucleotides) for treatment of cancer. In certain embodiments, the disclosure provides for methods and compositions for enhancing efficacy of anti-sense oligonucleotides. In still further embodiments, the disclosure provides methods and compositions for treatment of non-small cell lung cancer.
A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
A system for positioning and monitoring an animal during microscopy may include a base supporting the animal, a head holder attached to the base and securing the animal's head, a body holder attached to the base and restraining the animal's body, at least one sensor measuring a physiological parameter of the animal, and a controller receiving and processing data from the at least one sensor. The base may comprise a scissor lifting jack for height adjustment. The head holder may include a ball joint for angular adjustment. The body holder may comprise a swaddle. Sensors may include an accelerometer to detect motion and a thermocouple to measure cranial window temperature. The system may also include a camera to capture images during microscopy.
A system, method, and means for manipulating deformable objects are provided. The system may comprise a baseplate and at least one appendage actuation module configured to mount on the baseplate. The at least one appendage actuation module may include an appendage of rigid and elongate construction, a platform, and at least one actuation device. The at least one actuation device may be in coupled arrangement with the appendage and the platform to cause the appendage to move in at least three degrees-of-freedom, at least including an axis of linear translation and an axis of rotation, with respect to the baseplate. The at least one appendage actuation module may be capable of actuating the appendage with sufficient force to manipulate the deformable objects along a plurality of degrees of motion, at least including three axes of rotation. Embodiments may be useful for robotic automation in food processing or assistive technologies.
Disclosed are polymers, methods of making polymers, and compositions, focused on cross-linking heterocycles comprising a moiety of Formula I with thiols and thiolates.
A61K 8/49 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
A61K 8/58 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
A61K 8/65 - CollagenGelatinKeratinDerivatives or degradation products thereof
A61K 47/22 - Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
C08F 283/06 - Macromolecular compounds obtained by polymerising monomers on to polymers provided for in subclass on to polyethers, polyoxymethylenes or polyacetals
C08F 289/00 - Macromolecular compounds obtained by polymerising monomers on to macromolecular compounds not provided for in groups
C08G 75/06 - Polythioethers from cyclic thioethers
C09D 1/00 - Coating compositions, e.g. paints, varnishes or lacquers, based on inorganic substances
Described herein is a lithium-ion battery comprising a cathode current collector, a cathode, a paper separator having a surface coated with an anti-shorting layer, an anode, and an anode current collector, wherein the cathode current collector is in contact with the cathode, the cathode is in contact with the paper separator, the paper separator is in contact with the anode, and the anode is in contact with the anode current collector. The lithium-ion battery can be fabricated by printing a cathode ink onto a first side of a paper separator having a surface coated with Al2O3, printing an anode ink onto a second side of said paper separator, printing a cathode current collector ink on the cathode, and printing an anode current collector ink on the anode.
H01M 4/131 - Electrodes based on mixed oxides or hydroxides, or on mixtures of oxides or hydroxides, e.g. LiCoOx
H01M 4/1391 - Processes of manufacture of electrodes based on mixed oxides or hydroxides, or on mixtures of oxides or hydroxides, e.g. LiCoOx
H01M 4/58 - Selection of substances as active materials, active masses, active liquids of inorganic compounds other than oxides or hydroxides, e.g. sulfides, selenides, tellurides, halogenides or LiCoFySelection of substances as active materials, active masses, active liquids of polyanionic structures, e.g. phosphates, silicates or borates
H01M 4/62 - Selection of inactive substances as ingredients for active masses, e.g. binders, fillers
H01M 10/0525 - Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodesLithium-ion batteries
H01M 50/11 - Primary casingsJackets or wrappings characterised by their shape or physical structure having a chip structure, e.g. micro-sized batteries integrated on chips
H01M 50/586 - Means for preventing undesired use or discharge for preventing incorrect connections inside or outside the batteries inside the batteries, e.g. incorrect connections of electrodes
30.
Smart and Real-time Digital Twins for Open, Programmable and Virtualized Wireless Network Systems
Embodiments disclose a computer-implemented system for representing a wireless communications network. The system includes a digital twinning platform including a real-world twin component and a virtual-world twin component representing at least a matching subset of layers of a full stack wireless communications network, and a communications module configured to enable bi-directional flow of data representing state information corresponding to the subset of layers of the real-world component and the virtual-world component.
G06F 30/18 - Network design, e.g. design based on topological or interconnect aspects of utility systems, piping, heating ventilation air conditioning [HVAC] or cabling
Error-corrected communication is provided. A base matrix is constructed. The base matrix comprises a plurality of columns. A plurality of permutations is applied to the base matrix to obtain a plurality of permuted matrices. A parity-check matrix is generated by concatenating the plurality of permuted matrices. A plurality of codewords is generated based on the parity-check matrix. A message is encoded according to the plurality of codewords. The encoded message is transmitted via a noisy channel.
H03M 13/11 - Error detection or forward error correction by redundancy in data representation, i.e. code words containing more digits than the source words using block codes, i.e. a predetermined number of check bits joined to a predetermined number of information bits using multiple parity bits
32.
Aqueous-Based High Nickel Electrodes Manufacturing Using Sustainable Cellulose Nanomaterials as Protector
Provided herein, in various embodiments, are methods for making a water-stable electrode by combining a mixture of cellulose nanofibers (CNF) and cellulose nanocrystals (CNC). Also described in embodiments herein are water-stables electrode comprising a mixture of CNF and CNC as a hybrid binder. Also described herein are batteries and devices. Also described herein are methods of protecting an electrode in water from delithiation.
H01M 4/02 - Electrodes composed of, or comprising, active material
H01M 4/131 - Electrodes based on mixed oxides or hydroxides, or on mixtures of oxides or hydroxides, e.g. LiCoOx
H01M 4/1391 - Processes of manufacture of electrodes based on mixed oxides or hydroxides, or on mixtures of oxides or hydroxides, e.g. LiCoOx
H01M 4/525 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of nickel, cobalt or iron of mixed oxides or hydroxides containing iron, cobalt or nickel for inserting or intercalating light metals, e.g. LiNiO2, LiCoO2 or LiCoOxFy
H01M 10/0525 - Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodesLithium-ion batteries
33.
SYSTEM AND METHOD FOR PROTEOMIC ANALYSIS OF LIMITED SAMPLES
Top-down proteomics analysis of limited biological samples as small as a single cell is provided using ultralow flow liquid chromatography with novel porous layer open tubular (PLOT) columns combined with mass spectrometry. The PLOT columns are fabricated such that the porous polymer stationary phase has uniform thickness and improved durability, run- to-run and column-to-column reproducibility, and resists clogging. As a result, the new PLOT columns are especially well-suited for all modes of proteomics analysis.
The present disclosure provides a unidirectional actuator with customizable series elasticity. The actuator includes a winch, a cable coupled to the winch, a spring-loaded idler engaged with the cable, and a cam coupled to the spring-loaded idler. The spring-loaded idler comprises an idler arm and a spring member. The cam is shaped to provide a nonlinear stiffness versus force characteristic for the spring-loaded idler. The actuator can be applied in various applications, such as an ankle exoskeleton.
The present disclosure provides methods of delivering a nucleic acid molecule to a large peritoneal macrophage (LPM), by contacting a nanoparticle encapsulating the nucleic acid molecule with the LPM, thereby delivering the nucleic acid molecule to the LPM, and compositions generated by these methods. The disclosure also provides methods of delivering an LPM comprising a nanoparticle encapsulating the nucleic acid molecule to an injured tissue in a subject in need thereof, and methods of treating a disease in the subject, e.g., an inflammatory disease, an infectious disease, an autoimmune disease, or a cancer using these LPMs.
C12N 15/88 - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using liposome vesicle
A61K 35/15 - Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cellsMyeloid precursor cellsAntigen-presenting cells, e.g. dendritic cells
C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
Government of the United States as Represented by the Secretary of the Air Force (USA)
Inventor
Rifat, Shahriar
Restuccia, Francesco
Ashdown, Jonathan
Turck, Kurt
Abstract
Adapters for Deep Neural Networks (DNNs) are described for use in the presence of corruption/noise affecting inputs. These adapters can proactively learn latent representations of different corruption types, each associated with a sub-network state tailored to correctly classify inputs affected by that corruption. After deployment, they adapt the DNN to previously unseen corruptions in an unsupervised fashion by (i) estimating the latent representation of the ongoing corruption; (ii) selecting the sub-network whose associated corruption is the closest in the latent space to the ongoing corruption; and (iii) adapting the DNN state, so that its representation matches the ongoing corruption. Resource-efficient and swift adaptation to new distributions caused by different corruptions can be achieved without requiring a large variety of input data.
G06V 10/98 - Detection or correction of errors, e.g. by rescanning the pattern or by human interventionEvaluation of the quality of the acquired patterns
G06V 10/74 - Image or video pattern matchingProximity measures in feature spaces
Provided herein are systems and methods for selecting a mm wave network sector for use by a vehicle operating within a network environment, the method including collecting data from a plurality of non-RF sensors on the vehicle, training, by the collected data in a deep learning inference (DL) engine, a locally trained model analyzing, using the trained model and the DL engine, the collected data to predict a sector of the mm wave network having a best alignment at a position of the vehicle; and probing the predicted sector of the mm wave network.
H04W 4/44 - Services specially adapted for particular environments, situations or purposes for vehicles, e.g. vehicle-to-pedestrians [V2P] for communication between vehicles and infrastructures, e.g. vehicle-to-cloud [V2C] or vehicle-to-home [V2H]
H04W 48/16 - DiscoveringProcessing access restriction or access information
38.
Analysis of Non-nutritive Sucking in Infants Using Computer Vision and Action Segmentation
Provided herein are methods and systems for detecting non-nutritive sucking (NNS) by an infant in a video recording and determining the start and end times of the NNS. The NNS detection method includes creating video segments from the video recording. For each video segment, action recognition is performed that includes determining a face bounding box for each frame of the video segment. The frames are cropped based on the bounding box. For each cropped frame, an optical flow frame is generated of the optical flow direction vectors for pixels of the cropped frame. Using a convolution network and the optical flow frames, a segment feature vector is determined from the pre-classification feature layer of the convolution network. The segment feature vector corresponding to each video segment is used as input to a dilated convolution network to predict an NNS action and determine the start and end time of the NNS.
An implant system includes an electrode portion comprising plural electrodes to perform nerve stimulation and nerve sensing, an impedance controller configured to selectively connect the plural electrodes between a stimulator to perform nerve stimulation and a sensor to perform nerve sensing based on a control signal, and set an impedance of each of the plural electrodes, and a processor configured to control a contact impedance by the plural electrodes by generating the control signal to control at least one of plural switches connected respectively to the plural electrodes, or variable resistors connected respectively to the plural electrodes, based on at least one of a selectively set purpose of the plural electrodes or a position of an electrode to which nerve stimulation is to be provided.
Provided are microorganisms, systems and methods for modulating H2S. In certain aspects, the present disclosure provides genetically engineered microorganisms capable of consuming H2S, converting H2S to L-cysteine, L-cysteine to glutathione, or to persulfides, polysulfides, or sulfur clusters. In certain aspects, the present disclosure provides genetically engineered microorganisms capable of producing H2S, degrading glutathione to L-cysteine and H2S, or reducing sulfite to H2S. In certain aspects, the present disclosure provides genetically engineered microorganisms capable of sensing environmental cues associated with a disease states and turning on H2S consumption pathways.
A computer-implemented method for predicting customer sentiment for a product is provided. Customer data is received for multiple products and a vector of customer sentiments is generated that is associated with different aspects of the products. Images are received for multiple products and a latent vector for the images are generated using a pre-trained image processing model. Textual description for products is received and a latent vector for the textual description is generated using a pre-trained natural language processing model. A deep multimodal design evaluation (DMDE) model is designed to integrate the latent vectors of the images and the textual descriptions to predict customer sentiment for new product designs based on their images and textual descriptions. A new product design is provided to the trained DMDE model to obtain predicted customer sentiments for one or more attributes or a new product design is generated with favorable predicted customer sentiments.
The present disclosure provides a robotic system for safe human-robot interaction. The system includes a robot body, a plurality of tactile sensors disposed on the robot body to detect contact, and a control system operatively connected to the tactile sensors. The control system receives tactile data from the tactile sensors, determines a safety action based on the tactile data, and controls the robot body to perform the safety action in response to detected contact. The safety action may comprise retracting the robot body away from a detected contact point. The control system can determine a contact force based on the tactile data and adjust a magnitude of the safety action based on the determined contact force. The system enables adaptive and responsive robot behavior to enhance safety during human-robot interactions.
Methods, systems, and computer products are presented herein for generating a clock signal using an on-chip ultra-low power (ULP) RC oscillator. An on-chip ultra-low power (ULP) RC oscillator comprises a first comparator, a second comparator, and a flip flop. The first comparator comprises a first input electrically coupled to a first bias voltage generation circuit and a second input electrically coupled to a first capacitor circuit. Each of the first bias voltage and the second bias voltage directly varies with a thermal voltage. A flip-flop is electrically coupled to the first comparator and the second comparator. The flip-flop is configured to generate a clock signal based on the first and the second comparator output signals.
H03B 5/04 - Modifications of generator to compensate for variations in physical values, e.g. power supply, load, temperature
H03B 5/24 - Generation of oscillations using amplifier with regenerative feedback from output to input with frequency-determining element comprising resistance and either capacitance or inductance, e.g. phase-shift oscillator active element in amplifier being semiconductor device
An apparatus and method for producing oriented polymer films are disclosed. The apparatus includes a curved enclosure configured to rotate and a flow obstacle. The curved enclosure has an interior volume with an opening at one end. The flow obstacle extends through the opening and interior volume, with one end rigidly coupled to a mounting plate. The flow obstacle's position is adjustable to contact the interior surface of the curved enclosure, defining a gap between them. The method involves introducing a material into the curved enclosure, adjusting the flow obstacle's position, and rotating the curved enclosure to generate an extensional flow within the material. The apparatus and method may be used for producing two-dimensional polymer films and can incorporate features such as inert gas flushing, heating systems, and various blade configurations for the flow obstacle.
B29C 48/08 - Flat, e.g. panels flexible, e.g. films
B29C 48/14 - Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired formApparatus therefor characterised by the particular extruding conditions, e.g. in a modified atmosphere or by using vibration
Disclosed are adhesive materials comprising a polymer and a filler; wherein a) if the temperature of the adhesive material is equal to or below a reference temperature, then the adhesive material adheres to an adherend; and b) if the temperature of the adhesive material is above the reference temperature, then the adhesive does not adhere to an adherend. Further disclosed are methods of making the adhesive materials.
C09J 5/06 - Adhesive processes in generalAdhesive processes not provided for elsewhere, e.g. relating to primers involving heating of the applied adhesive
Methods, systems, and computer program products are presented herein for circuit timing using ultra-low power (ULP) timing circuit systems. A ULP timing circuit system comprises a receiver circuit, phase lock loop (PLL) circuit, crystal oscillator (XO) circuit, temperature sensing and calibration circuit, and temperature compensation circuit. The receiver circuit is configured to receive a reference clock signal. The XO circuit is configured to produce an output clock signal. The PLL circuit is configured to produce a control signal based on the reference clock signal and output clock signal. The temperature compensation circuit is configured to produce a compensation signal based on an operating temperature. The temperature sensing and calibration circuit is configured to sense the operating temperature and to calibrate the XO circuit based on the operating temperature, control signal, and compensation signal to lock a frequency of the output clock signal to the reference clock signal.
H03K 3/011 - Modifications of generator to compensate for variations in physical values, e.g. voltage, temperature
H03K 5/135 - Arrangements having a single output and transforming input signals into pulses delivered at desired time intervals by the use of time reference signals, e.g. clock signals
H03L 7/099 - Details of the phase-locked loop concerning mainly the controlled oscillator of the loop
Methods, systems, and computer products are presented herein for determining temperature using ultra-low power temperature sensing systems. An ultra-low power (ULP) temperature sensing system comprises a proportional to absolute temperature (PTAT) current source, a switched-capacitor converter electrically coupled to the PTAT current source, and a ULP analog-to-digital converter (ADC) electrically coupled to the PTAT current source and the switched-capacitor converter. The PTAT current source is configured to generate a PTAT current that varies with an operating temperature. The switched-capacitor converter is configured to generate an analog voltage signal based on the PTAT current. The ULP ADC is configured to output a digital voltage value corresponding to the analog voltage signal.
H03L 1/02 - Stabilisation of generator output against variations of physical values, e.g. power supply against variations of temperature only
G05F 3/30 - Regulators using the difference between the base-emitter voltages of two bipolar transistors operating at different current densities
H03M 1/46 - Analogue value compared with reference values sequentially only, e.g. successive approximation type with digital/analogue converter for supplying reference values to converter
48.
ISOLATION AND EXPANSION OF NATURAL KILLER CELLS USING FLUORESCENCE-ACTIVATED DROPLET SORTING
A high-throughput microfluidics-based fluorescence activated droplet sorting (FADS) system provides activation, sorting, and feeder cell-free expansion of NK cells that are enriched for killing activity. The NK cells are activated and identified based on their ability to kill target cells, such as tumor cells, without prior sensitization. The diversity of endogenous NK cells can be overcome to allow selection of a highly effective population of cells for therapeutic use, such as in the treatment of cancer.
Provided herein are methods and systems for radio access network (RAN) control including receiving, at a base station controller deployed at a base station of the RAN, a data input corresponding to a real-time operational status of the base station; determining a locally optimal signal configuration of the base station; controlling the base station to change a configuration of a signaling component to implement the locally optimal signal configuration; receiving, at an edge controller deployed at an edge of the RAN, a plurality of the locally optimal signal configurations corresponding to a plurality of the base stations within the RAN; determining a coordinated optimal signal configuration of each base station; and instructing, by the edge controller, the base station controller to change a configuration of the signaling component of the base station from the locally optimal signal configuration to the coordinated optimal signal configuration.
New York University in Abu Dhabi Corporation (United Arab Emirates)
Technical University of Dortmund (Germany)
Inventor
Bitsikas, Evangelos
Schnitzler, Theodor
Pöpper, Christina
Ranganathan, Aanjhan
Abstract
Systems, computer program products, and methods are disclosed for predicting a location of a target device. A method comprises sending a short message service (SMS) to a target device, via a short message service center (SMSC); receiving, from the target device and through the SMSC, a delivery report; providing the delivery report as an input to a pretrained machine learning model; deriving one or more fingerprints from the delivery report, thereby creating a target data model based on the one or more fingerprints; predicting, based on the target data model, a location of the target device.
Provided herein are programmable intelligent surfaces (PIS) for transmitting power and/or signals to a device positioned on or proximate the surface including at least one resonant unit including a power distribution layer having at least one transmitter coil configured to be energized by a power source and generate an electromagnetic field sized to electrically interact with at least one meta-cell coil of a meta-resonance layer, and the meta-resonance layer extending over the power distribution layer and comprising an array of configurable meta-cells, each including at least one of the meta-cell coils configured to selectively amplify, block, modify, or pass unchanged the electromagnetic field generated by the transmitter coil.
H02J 50/12 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling of the resonant type
H02J 50/00 - Circuit arrangements or systems for wireless supply or distribution of electric power
H02J 50/40 - Circuit arrangements or systems for wireless supply or distribution of electric power using two or more transmitting or receiving devices
H02J 50/90 - Circuit arrangements or systems for wireless supply or distribution of electric power involving detection or optimisation of position, e.g. alignment
Devices, systems, and methods can be used for the automated production of dendritic cells (DC) from dendritic cell progenitors, such as monocytes obtained from peripheral blood. The invention makes it possible to obtain sufficient quantities of a subject's own DC for use in preparing and characterizing vaccines, for activating and characterizing the activation state of the subject's immune response, and to aid in preventing and/or treating cancer or infectious disease.
Provided herein are, in various embodiments, are bottlebrush polymer-oligonucleotides conjugates. In certain embodiments, the conjugates are potent in vivo, have improved biopharmaceutical properties, enhanced transfection efficiency, and/or an unconventional biodistribution profile. Also provided herein are pharmaceutical compositions, methods of treatment, and methods of making bottlebrush polymer-oligonucleotide conjugates.
A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
C12N 15/115 - Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith
54.
System And Method For Joint Dynamic Forwarding And Caching In Content Distribution Networks
A system and method for joint dynamic interest request forwarding and dynamic cache placement and eviction and provided within the context of the Named Data Networking (NDN) architecture. The system and method employ a virtual control plane that operates on the user demand rate for data objects in the network, and an actual plane that handles Interest Packets and Data Packets. Distributed algorithms within the virtual plane achieve network load balancing through dynamic forwarding and caching, thereby maximizing the user demand rate that the NDN network can satisfy. A method of congestion control is also provided to achieve optimal network fairness using the VIP framework.
UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (USA)
NORTHEASTERN UNIVERSITY (USA)
THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPT. OF VETERANS AFFAIRS (USA)
Inventor
Akcakaya, Murat
Kocanaogullari, Deniz
Grattan, Emily
Wittenberg, George F.
Mak, Jennifer
Ostadabbas, Sarah
Huang, Xiaofei
Abstract
A method of determining an extent of visual spatial neglect of a patient includes providing a software-based test to the patient via a presentation apparatus positioned on the head of the patient and having a display device positioned close and in front of the eyes of the patient. EEG information is collected from the patient during the test via an EEG apparatus positioned on the head of the patient. Portions of the EEG information collected during the test are used to determine the extent of the visual spatial neglect of the patient. An indication of the extent of the visual spatial neglect of the patient is provided.
Provided herein are methods and systems for a computer implemented method for designing and optimizing a fabrication process characterized by one or more process parameters. The outcome of the fabrication process is characterized by a quality metric used to optimize the fabrication process. The method uses a classification model in conjunction with a regression model, both using artificial intelligence and trained using experimental results, to iteratively recommend process parameter values for performing real world fabrication experiments. The experimental results are used to continuously train the models. The outcome is a set of process parameters that yield an optimal fabrication process with less time and effort than using conventional design of experiment methods.
G06F 30/27 - Design optimisation, verification or simulation using machine learning, e.g. artificial intelligence, neural networks, support vector machines [SVM] or training a model
G06F 18/2415 - Classification techniques relating to the classification model, e.g. parametric or non-parametric approaches based on parametric or probabilistic models, e.g. based on likelihood ratio or false acceptance rate versus a false rejection rate
57.
SUBAMBIENT DAYTIME COOLING ENABLED BY HIERARCHICALLY ARCHITECTED ALL-INORGANIC METAPAPER WITH ENHANCED THERMAL DISSIPATION
A quantitative, ultrashort time to echo, contrast-enhanced magnetic resonance imaging technique is provided. The technique can be used to accurately measure contrast agent concentration in the blood, to provide clear, high-definition angiograms, and to measure absolute quantities of cerebral blood volume on a voxel-by-voxel basis.
A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
Systems and methods for high throughput microdroplet-based single cell assays in microdroplets are provided. The system and methods use parallel devices and switches to enable simultaneous analysis of different cells or cell combinations, or different assay conditions, on a single microfluidic chip. Interconnections between the inlets of individual devices on a common chip enable simultaneous screening of the effect of different combinations of drugs on single cells. The use of an oil inlet and microchannels with matched total flow resistance allows the synchronous generation of droplets with the same dimensions and/or volumes.
Research Foundation for State University New York (USA)
Northeastern University (USA)
Inventor
Egan, James E.
Ojima, Iwao
Amiji, Mansoor M.
Botchkina, Galina Ivanovna
Abstract
A composition of an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate encapsulated in an oil-in-water nanoemulsion (NE) drug delivery system. A method of treating cancer by administering an effective amount of a pharmaceutical composition including a PUFA-taxoid conjugate encapsulated in an oil-in-water NE drug delivery system to a subject in need of treatment, and treating cancer. A method of overcoming multidrug resistance by exposing a multidrug resistant cell to an effective amount of a pharmaceutical composition including an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate encapsulated in an oil-in-water NE drug delivery system, and inducing the death of the multidrug resistant cell. A method of eliminating a cancer stem cell. Methods of reducing stemness of a cancer stem cell, retaining drug in the body, and providing a slower release profile.
A61K 31/337 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
A61K 47/12 - Carboxylic acidsSalts or anhydrides thereof
A61K 47/44 - Oils, fats or waxes according to two or more groups of Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
61.
OBFUSCATING ANALOG CIRCUITS USING SWITCHED PHASE CIRCUITS
Methods, systems, and computer program products are presented herein for obfuscating analog circuits using switched phase circuits. In particular, methods, systems, and computer program products using a Switch Mode Time Domain Locking (SMDL) scheme, presented herein, may be used to protect analog circuits. A first input signal to an analog circuit is generated. The first input signal comprises a reference phase. The analog circuit is adapted to perform a predetermined function. A second input signal to the analog circuit is generated. The second input signal comprises a provided phase. Enablement of the predetermined function of the analog circuit is toggled based on alignment of the reference phase and the provided phase.
A method of delivering a therapeutic agent into the central nervous system through the blood-brain barrier includes implanting an implant within the submucosal space of the olfactory epithelium. The implant can provide sustained drug delivery to the brain. The implant can be placed using a minimally invasive surgical approach.
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
63.
Device for High Throughput Isolation and Cultivation of Microbial Species
High capacity, low cost devices for use in growing monocultures of novel, previously unknown microbial species contain adhesive layers with wells covered by nanoporous membranes. The devices are placed in natural environments for cultivation of unknown microbial species.
Compounds able to modulate the endocannabinoid system, their preparation and method of use in the treatment and prevention of diseases in which modulation of the receptor is beneficial are described. Also described are pharmaceutically acceptable compositions comprising the disclosed compounds and methods of using said compositions in the treatment of various disorders, diseases, or conditions, in which modulation of the endocannabinoid system is beneficial.
C07D 209/10 - IndolesHydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
C07D 209/14 - Radicals substituted by nitrogen atoms, not forming part of a nitro radical
C07D 409/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
A61P 25/00 - Drugs for disorders of the nervous system
CHRISTIAN-ALBRECHTS-UNIVERSITÄT ZU KIEL, KÖRPERSCHAFT DES ÖFFENTLICHEN RECHTS (Germany)
NORTHEASTERN UNIVERSITY (USA)
Inventor
Bald, Christin
Bergholz, Robert
Klinkenbusch, Ludger
Quandt, Eckhard
Schmidt, Tobias
Schmidt, Gerhard
Sun, Nian
Abstract
The invention relates to a device for magnetic pose estimation of an object in a measurement volume to which a reference magnetic field is applied, comprising: at least four electrically activatable magnetic-field generators having various predetermined poses in the edge region of the measurement volume; at least one magnetic-field sensor rigidly connected to the object; a control unit for predeterminable electrical activation of the magnetic-field generators; and an evaluation unit for receiving and evaluating the electrical output signal from the at least one magnetic-field sensor; a. the at least one magnetic-field sensor being in the form of a magnetoelectric bending-beam sensor having a known mechanical resonant frequency for simultaneously measuring three linearly independent components of the reference magnetic field; and b. the control unit being designed to perform the electrical activation of the magnetic-field generators in a band-limited manner close to the mechanical resonant frequency of the magnetic field sensor; and c. the evaluation unit being designed to estimate from the output signal from the at least one magnetic-field sensor, using predetermined and tabulated matched filters, the pose of the object in the measurement volume; d. at least four of the magnetic-field generators being in the form of magnetoelectric transmitters.
A61B 34/20 - Surgical navigation systemsDevices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
G01R 33/02 - Measuring direction or magnitude of magnetic fields or magnetic flux
A61B 17/00 - Surgical instruments, devices or methods
G01B 7/004 - Measuring arrangements characterised by the use of electric or magnetic techniques for measuring coordinates of points
G01B 7/30 - Measuring arrangements characterised by the use of electric or magnetic techniques for measuring angles or tapersMeasuring arrangements characterised by the use of electric or magnetic techniques for testing the alignment of axes
66.
NANOPORE AND MEMBRANE PROTEIN MULTICHANNEL MEASUREMENT APPARATUS AND FABRICATION METHOD
Embodiments disclose a pore sensing fluidic device. The pore sensing fluidic device includes a structure defining a common inflow channel, shared channel with a plurality of apertures, a plurality of recording chambers, a common return channel, and a plurality of control channels arranged to support a fluid flow within the structure. The plurality of control channels connects the common inflow channel to the shared channel and the plurality of recording chambers. The fluidic device includes a sealer configured to isolate the plurality of recording chambers from the plurality of control channels. A membrane is formed and coupled to each of the plurality of apertures, and a pore is inserted into each membrane. A sensor, coupled to each of the plurality of apertures, is configured to produce a representation of flow through each of the plurality of membrane pores.
UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (USA)
NORTHEASTERN UNIVERSITY (USA)
Inventor
Wagner, Alicia N.
Trombley, Roger
Podgurski, Maris E.
Smith, Jacqueline R.
Cui, Meng
Marin, Adriana A.
Maher, Steven P.
Kyle, Dennis E.
Manetsch, Roman
Ruberto, Anthony A.
Abstract
Plasmodium falciparumPlasmodium falciparumPlasmodium Plasmodium species. In another aspect, the compounds are soluble in aqueous solutions at pH 7.4, making them suitable for oral administration to patients. Also disclosed are methods of making the compounds, pharmaceutical compositions comprising the same, and methods of treating or preventing malaria using the same. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
A61K 31/4418 - Non-condensed pyridinesHydrogenated derivatives thereof having a carbocyclic ring directly attached to the heterocyclic ring, e.g. cyproheptadine
UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (USA)
NORTHEASTERN UNIVERSITY (USA)
Inventor
Kyle, Dennis E.
Maher, Steven
Asakawa, Ami H.
Diagne, Khaly D.
Manetsch, Roman
Marin, Adriana A.
Marasciullo, Anthony
Consoli, Caroline E.
De Castro, Sagan Thomas
Mcwhorther, Olivia Isabelle
Cui, Meng
Abstract
Plasmodium Plasmodium spp. in the parasite's various stages, such as, for example, the erythrocytic and exoerythrocytic stages, and pharmaceutical compositions comprising same. In one aspect, the compounds are tetrahydroacridinones having the structure I described herein. In another aspect, the compounds described herein can be used to treat or prevent malaria in a subject.
An all solid-state Li metal microbattery is fabricated by directed assembly-based printing of nanoparticles on a substrate, which facilitates the fabrication of all battery components, including cathode, anode, and solid electrolyte at microscale dimensions and without the need for costly and complex fabrication techniques. The porous cathode material allows polymer electrolyte to be intercalated within the cathode, resulting in a cathode-supported electrolyte membrane which enhances battery performance through superior ionic transport, low interfacial resistance between the electrolyte and the cathode, and providing electronic pathways through the cathode framework.
H01M 50/11 - Primary casingsJackets or wrappings characterised by their shape or physical structure having a chip structure, e.g. micro-sized batteries integrated on chips
H01M 4/02 - Electrodes composed of, or comprising, active material
H01M 4/36 - Selection of substances as active materials, active masses, active liquids
H01M 4/58 - Selection of substances as active materials, active masses, active liquids of inorganic compounds other than oxides or hydroxides, e.g. sulfides, selenides, tellurides, halogenides or LiCoFySelection of substances as active materials, active masses, active liquids of polyanionic structures, e.g. phosphates, silicates or borates
H01M 4/587 - Carbonaceous material, e.g. graphite-intercalation compounds or CFx for inserting or intercalating light metals
H01M 10/0565 - Polymeric materials, e.g. gel-type or solid-type
The invention provides cell culture chambers and methods of use thereof. In certain embodiments, the cell culture chambers and methods provide for an expansion and stimulation of T-cells using autologous antigen-presented cells to provide a therapeutic T-cell product that can mobilize a patient's own immune system in a manner that selectively targets a patient's tumor.
A system and method for assessing properties of particles, the system comprising: a first structure defining an interior cavity, configured to contain an interior cavity fluid, and a barrier separating the interior cavity from an exterior cavity configured to contain an exterior cavity fluid, the barrier defining a nanopore therethrough fluidically coupling the interior and exterior cavities, the first structure further comprising at least one feature configured to interface with at least one complementary feature of a second structure that defines the exterior cavity; and electrodes configured to energize and apply a voltage gradient across the nanopore between the interior cavity and exterior cavity, the voltage gradient of sufficient magnitude to induce particles to migrate via the nanopore between the interior cavity and the exterior cavity and produce an electronic signature representative of at least one property of the particles.
The present technology provides a genetically modified immune cell expressing a chimeric antigen receptor (CAR) and also expressing an elevated level of a ligand for a tumor necrosis factor (TNF) receptor. The genetically modified cell takes advantage of dual pathways for killing cancer cells, cellular pathogens, and cells infected with viruses. The CAR- mediated pathway promotes killing action by perforin and granzymes released by cytotoxic T lymphocytes and natural killer cells, as well as the TNF receptor (i.e., death domain) mediated target cell killing by these same cells. Further, the present technology, especially when combined with single cell image analysis, microfluidics based cell sorting, and transcriptomic analysis makes it possible to adapt genetic modifications to cells of a patient, in response to significant patient to patient variation in gene expression of T cells and NK cells.
In a process for manufacturing molded ceramic composite materials, a preform of a ceramic composite material is provided in which ceramic particles having a platelet configuration are formed within a ceramic matrix. The preform is thermoformed within a mold by heating to a temperature greater than a melting or softening temperature of the ceramic matrix and applying a load to deform the preform to form the molded ceramic composite material in a desired configuration. The process is used to fabricate precisely molded ceramic composite materials and devices containing them. The materials and devices can be used for thermal management, such as for electronic components and other heat generating structures.
A method for broadband, high-efficiency spin wave transduction adopts a slow-wave structure to enhance the interaction of electromagnetic waves and spin waves.
Provided herein are methods and systems for deployment and orchestration of network intelligence in an Open RAN including receiving requests at a request collector, selecting one, by an orchestration engine, or more ML/Al models applicable for satisfying the plurality of collected requests, assigning at least one Open RAN resource to execute each of the ML/Al models, automatically generating, by an orchestration engine, executable software components embedding at least one of the ML/Al models, dispatching each executable software component to the assigned Open RAN resource, and instantiating, at the Open RAN resource, at least one of the ML/AI models embedded in the executable software component to configure the Open RAN to satisfy the requests.
An on-chip acoustic delay line (ADL) for operation in the radio frequency (RF) range uses a two-dimensional array of resonant rods and a piezoelectric layer having corrugated structure. The ADL has one or more programmable passband frequencies which are determined by the lithographically-defined artificial dispersive characteristics of acoustic metamaterials formed by forests of the locally resonant rods and selectable attached matching networks. The ADL devices offer exceptionally high fractional bandwidth and low insertion loss. The ADL can be used in self-interference cancellation networks to provide full duplex radio.
H03H 9/40 - Frequency-dependent delay lines, e.g. dispersive delay lines
H03H 3/02 - Apparatus or processes specially adapted for the manufacture of impedance networks, resonating circuits, resonators for the manufacture of electromechanical resonators or networks for the manufacture of piezoelectric or electrostrictive resonators or networks
Systems and methods are provided for in-bed pose and posture determination and tracking for a human subject including an imaging device, the imaging device positioned proximate to a bed and oriented to capture images of the subject lying in the bed, and a processing unit operative to receive the captured images, the captured images including a plurality of image frames, the processing unit including a pose estimation module trained with a dataset of lying poses and operative to estimate poses of the subject lying in the bed based the image frames, and a posture classification module trained with the dataset of lying poses and operative to classify positions of the subject lying in the bed based on the image frames, the processing unit operative to determine a pose and posture of the subject lying in the bed.
G06V 10/50 - Extraction of image or video features by performing operations within image blocksExtraction of image or video features by using histograms, e.g. histogram of oriented gradients [HoG]Extraction of image or video features by summing image-intensity valuesProjection analysis
G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
G06V 10/94 - Hardware or software architectures specially adapted for image or video understanding
G06V 40/10 - Human or animal bodies, e.g. vehicle occupants or pedestriansBody parts, e.g. hands
In embodiments, a method includes the following operations. For each qubit gate of a quantum circuit within a qubit frontier of a circuit operation of qubit gates of the circuit, the method (a) determines a set of three-or-more-qubit blocks from the qubit frontier to an interior of the circuit, (b) determines a number of operations of a subset of blocks in the set of three-or-more-qubit blocks, (c) determines a family of blocks with a highest number of operations, (d) for each respective three-or-more-qubit block of the set, determines a block family with a highest number of available operations that starts with the respective three-or-more-qubit block and adheres to restriction zones of the blocks, and (e) adds a three-or-more-qubit block having a highest number of operations to a blocked circuit. Each qubit gate is a one-or-two-qubit gate of fewer bits than a number of bits of the three-or-more-qubit blocks.
A computer-based system and corresponding computer-implemented method for training a user via an emulated real-world building environment are provided. Based on an initial training input from a trainer user, a building simulation model is implemented. The building simulation model is configured to produce an emulated real-world building environment. For an iteration of the building simulation model, a value of at least one forcing function is determined. The at least one forcing function is associated with the emulated real-world building environment. Based on the value of the at least one forcing function determined and at least one building operation input received from a trainee user via a building training interface, a current state of the building simulation model is transformed into an updated state of the building simulation model. Based on the updated state and the initial training input, at least one building training item is generated for the trainee user.
The present disclosure generally relates to mixtures and compositions comprising sulforaphane, or analogue thereof, and at least one amino acid, or analogue thereof. In particular, the disclosure relates the use of the mixtures and compositions for treating or preventing oxidative stress.
Provided herein are methods and systems for a hard drive failure prediction system to determine a predicted hard drive failure within a time-in-advance determined time period. The system includes a machine-learning model, such as an XGBoost model, trained using historical hard drive operational data from a data center. The historical hard drive operation data corresponds to SMART attributes. Statistical analysis is performed to determine a set of SMART attributes most indicative of hard drive failure. The model is trained using the historical hard drive operational data corresponding to the set of SMART attributes. The accuracy results of the model are used to determine a time-in-advance value that balances accuracy with failure lead time. A signal length of operational data for a particular hard drive is provided as input to the trained model and an output indicates if the hard drive will fail within the time period of the time-in-advance value.
Embodiments disclosed herein may be implemented in the form of a method or corresponding apparatus for receiving or transmitting network communications carried at acoustic wavelengths via an acoustic medium. The corresponding method or apparatus may include a gate-level digital hardware module communicatively coupled to a communications module and define therein logic blocks configured to perform respective primitive processing functions, sequences of the logic blocks being capable of processing data units in accordance with any of the multiple communications protocols on a data unit-by-data unit basis without reconfiguring. According to some embodiments, the gate-level digital hardware module may be configured to process a data unit in accordance with a first communications protocol by directing the data unit through a first sequence of logic blocks, and process a subsequent data unit in accordance with a second communications protocol by directing the subsequent data unit through a second of sequence logic blocks.
H04B 11/00 - Transmission systems employing ultrasonic, sonic or infrasonic waves
H04B 13/02 - Transmission systems in which the medium consists of the earth or a large mass of water thereon, e.g. earth telegraphy
H04B 14/04 - Transmission systems not characterised by the medium used for transmission characterised by the use of pulse modulation using pulse code modulation
83.
Lipid-free anchoring of thermophilic bacteriophage G20c portal adapter into solid-state nanopores
Thermus thermophilus bacteriophage G20c, electrokinetically inserted into a larger nanopore in a solid-state membrane. The hybrid pore is stable and easy to fabricate, and exhibits low peripheral leakage, allowing sensing and discrimination among different types of biomolecules.
Voltage-gated sodium (NaV) channels are densely expressed in most excitable cells and activate in response to depolarization, causing a rapid influx of Na+ ions that initiates the action potential. The voltage-dependent activation of NaV channels is followed almost instantaneously by fast inactivation, setting the refractory period of excitable tissues. The gating cycle of NaV channels is subject to tight regulation, with perturbations leading to a range of pathophysiological states. The gating properties of most ion channels are regulated by the membrane phospholipid, phosphatidylinositol (4,5) bisphosphate (PI(4,5)P2). However, it is not known whether PI(4,5)P2 modulates the activity of NaV channels. Here, we utilize optogenetics to activate specific, membrane-associated phosphoinositide (PI)-phosphatases that dephosphorylate PI(4,5)P2 while simultaneously recording NaV1.4 channel currents. We show that dephosphorylating PI(4,5)P2 left-shifts the voltage-dependent gating of NaV1.4 to more hyperpolarized membrane potentials, augments the late current that persists after fast inactivation, and speeds the rate at which channels recover from fast inactivation. These effects are opposed by exogenous diC8PI(4,5)P2. We provide evidence that PI(4,5)P2 is a negative regulator that tunes the gating behavior of NaV1.4 channels.
A61K 31/132 - Amines, e.g. amantadine having two or more amino groups, e.g. spermidine, putrescine
A61K 31/137 - Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine
A61K 31/235 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
A61K 31/265 - Esters, e.g. nitroglycerine, selenocyanates of carbonic, thiocarbonic or thiocarboxylic acids, e.g. thioacetic acid, xanthogenic acid, trithiocarbonic acid
A61K 31/27 - Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, e.g. meprobamate, carbachol, neostigmine
A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
A61K 31/685 - Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
A61K 31/7036 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
Disclosed are methods of treating or preventing a cardiovascular disease. The method may comprise administering to a subject in need thereof an effective amount of a compound. The compound may be a SUMOylation inhibitor, an analogue of Phosphatidylinositol 4,5-bisphosphate (PIP2); PIP2; or a compound that increases endogenous PIP2.
A61K 31/7034 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
Provided herein are methods and systems for recognizing an infant action in a recorded video. The infant action recognition technique includes performing pose estimation for each frame of the video, where pose corresponds to skeletal joint locations and joint angles. A posture classifier uses the pose estimations to classify each pose estimation as one of five postures and a probability value for the posture. The infant action recognition technique further includes using the identified postures for each frame and the probability values to determine a period of uncertainty that corresponds to a transition segment. The infant action recognition technique further includes using the first and last frames of the transition segment to distinguish start and end stable postures. The technique further includes performing filtering and majority voting to remove outlier posture classifications and determine an infant action label for the video based on the start and end stable postures.
Disclosed are methods of culturing cells. The methods may comprise providing the cells and a culture incubator comprising a cell culture container; and an inflow of gas, wherein the cells are contained in the cell culture container. The methods may further comprise providing a continuous inflow of a cell culture gas to the culture incubator, incubating the cells in the culture incubator, monitoring the pericellular oxygen concentration of the cells in the cell culture container, and adjusting the inflow of the cell culture gas, thereby adjusting the pericellular oxygen concentration to a target oxygen concentration. Disclosed are culture incubators, comprising a cell culture container; and an inflow of gas, wherein cells are contained in the cell culture container.
The present technology provides solidly-mounted, bi-dimensional mode acoustic resonators for use in high frequency electronic applications. The resonator devices are designed to constrain acoustic energy in the piezoelectric layer and electrodes. By concentration of the acoustic waves on the surface and reducing substrate leakage, the quality factor of the system is maintained, even at high frequencies where other resonators fail. The resonance frequency of the devices can be tuned in the 1-27 GHz range. Fabrication of the devices is simplified and cost reduced compared to similar technologies, because the piezoelectric layer is solidly supported and does not have to be released from the substrate.
A biosensor that is configured to be implanted into a living being includes a light source configured to generate source light with a source light spectrum. The biosensor also includes plasmonic nano-antenna optically coupled to the light source to receive the source light and to emit light therefrom exhibiting a spectral signature of the plasmonic nano¬antenna. A bio-functionalized element joined to the plasmonic nano-antenna can receive a biomarker if available and effect a change in the spectral signature as a function of receipt or nonreceipt of the biomarker. A combination of the light source and nano-antenna can encode an optical communication signal into the emitted light and transmit the signal to a separate communication node. An optional detector can detect the emitted light and provide output indicative of receipt or nonreceipt of the biomarker, which can in turn be encoded into the communication signal for reporting to another node.
A61B 5/1459 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
Described herein is a sensor comprising a porous substrate comprising xanthommatin or a salt or a crosslinked derivative thereof. The sensor can be fabricated by distributing xanthommatin or a salt thereof throughout the porous substrate, and optionally crosslinking the distributed xanthommatin or a salt thereof. The sensors can be incorporated into microfluidic devices and/or used as wearable or mountable solar radiometers and/or UVC radiation detectors.
Provided herein are methods and systems for identifying one or more unused or underused portions of a wireless radio frequency (RF) spectrum including providing a multi-label multi-class machine learning classifier trained using a set of RF transmission data, receiving, by a receiver, wireless RF signals in an environment suspected of containing unused or underused portions of said RF spectrum, classifying the received wireless RF signals using the classifier; and identifying unused or underused portions of said RF spectrum.
4-phenyl-2-dimethylaminotetralin compounds, formulations, and methods are provided for selective modulation of serotonin 5-HT2A and 5-HT2C receptors without causing sedation at doses that are antipsychotic. Mechanisms for selective modulation are shown to involve inverse agonism at one or more of the 5-HT2A-2C receptors based on stereochemistry and substituents. The technology can be targeted to receptors inside or outside the central nervous system.
C07D 213/38 - Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
A61K 31/135 - Amines, e.g. amantadine having aromatic rings, e.g. methadone
A61K 31/341 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
A61K 31/381 - Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
A61K 31/4409 - Non-condensed pyridinesHydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
C07C 211/42 - Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems with six-membered aromatic rings being part of the condensed ring systems
C07C 211/49 - Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring having at least two amino groups bound to the carbon skeleton
C07D 307/52 - Radicals substituted by nitrogen atoms not forming part of a nitro radical
C07D 333/20 - Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
93.
Apparatus for Measuring and Dispensing Particulates
Systems and methods for controlled delivery of a specified quantity of particles. Systems involve a flow cell containing primary and secondary fluid chambers separated by a membrane, and a flow-producing module to induce particle translocation. Methods involve translocating particles between chambers through membrane activation, potentially for sorting and dispensing into target containers.
A compound having the following structure:
A compound having the following structure:
A compound having the following structure:
R1 is a hydrocarbon group containing at least one aromatic or heteroaromatic ring or fused ring system, wherein the at least one aromatic or heteroaromatic ring or fused ring system is optionally substituted; R2 and R3 are independently selected from the group consisting of hydrogen (H), halogen atom, and hydrocarbon groups containing 1-6 carbon atoms and optionally substituted; R4 and R5 are independently selected from H, halogen atom, and hydrocarbon groups containing 1-6 carbon atoms and optionally substituted; R6 is H or a hydrocarbon group containing 1-12 carbon atoms and optionally containing one or more heteroatoms selected from O, N, S, and F; and Ra, Rb, Rc, and Rd are independently selected from H; halogen atom; hydrocarbon groups containing 1-3 carbon atoms; amine groups; amide groups; and —(CH2)p—T groups, wherein T is a hydrocarbon group with —NH— linkage; and pharmaceutically acceptable salts thereof.
C07D 401/06 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
A61K 31/235 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
A61K 31/337 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
A61K 31/427 - Thiazoles not condensed and containing further heterocyclic rings
C07D 305/08 - Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring atoms
C07D 409/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
C07D 417/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
C12N 9/99 - Enzyme inactivation by chemical treatment
96.
ULTRA-LOW POWER BEAMFORMING WIRELESS POWER TRANSFER SYSTEM
Wireless power transfer (WPT) efficiency is enhanced using an ultra-low power (ULP) distributed beamforming technique. A phase and frequency offset correction technique is used for beam-forming optimization, a backscattering communication technique is used to reduce power over-head, and a new rectifier and MPT method is used for high efficiency RF-to-DC conversion.
H02J 50/20 - Circuit arrangements or systems for wireless supply or distribution of electric power using microwaves or radio frequency waves
H01Q 3/22 - Arrangements for changing or varying the orientation or the shape of the directional pattern of the waves radiated from an antenna or antenna system varying the orientation in accordance with variation of frequency of radiated wave
H02J 50/40 - Circuit arrangements or systems for wireless supply or distribution of electric power using two or more transmitting or receiving devices
H02J 50/80 - Circuit arrangements or systems for wireless supply or distribution of electric power involving the exchange of data, concerning supply or distribution of electric power, between transmitting devices and receiving devices
A robot comprises a body comprising a scalable joint module having a housing including an actuator within the housing powered by a voltage regulator on the housing and defining a female connector cavity of the housing; a first plurality of axial thrust roller bearings on the housing and a second plurality of axial thrust roller bearings on an opposite side of the housing, wherein each of the first and second plurality of axial thrust roller bearings are sandwiched between two washers; a male connector opposite from the female connector cavity; a head module coupled to the body, containing an onboard computing system controlling the movement of the lunar exploration robot, and an actuated latching mechanism; and a tail module coupled to the body, wherein the tail module defines a cavity configured for the actuated latching mechanism of the head module to enter, to thereby couple the head and tail modules.
B62D 57/02 - Vehicles characterised by having other propulsion or other ground-engaging means than wheels or endless track, alone or in addition to wheels or endless track with ground-engaging propulsion means, e.g. walking members
16 - Paper, cardboard and goods made from these materials
21 - HouseHold or kitchen utensils, containers and materials; glassware; porcelain; earthenware
Goods & Services
Clothing, such as, shirts; t-shirts; hats; toques, headwear, scarves, bandanas, headbands; visors being headwear; sports jerseys; sweatshirts; hoodies; pants; shorts; socks; gloves; pullovers; jackets; tank tops; athletic tops; baby tops; bandeau tops; bikini tops; bra tops; crop tops; halter tops; knit tops; rugby tops; sweatshirts and tops of sweatshirt material; tennis tops; tube tops; underwear clothing tops; vests and vest clothing tops; warm-up clothing tops; woven tops; yoga tops; fleece tops; cloth bibs; athletic bibs, bib overalls; bib shorts; bib tights; bibs for babies not of paper Paper goods and printed materials, such as, stickers, decals, paper notebooks, printed notebooks, paper notepads, printed notepads, blank writing journals, pens and pencils, document portfolios; printed calendars; printed appointment planners; paper coasters Household goods, including beverage glassware; drinkware; mugs; tumblers for use as drinking bottles; non-electric portable coolers, coasters not of paper or textiles, bottle openers; insulated sleeve holders for bottles; and water bottles sold empty
99.
ISING TAG WITH MICROACOUSTIC RESONATOR FOR TEMPERATURE THRESHOLD SENSOR
Provided herein are Ising tags for threshold sensing of a parameter of interest having a first parametric oscillator (PO), a second PO coupled to and power-combined with the first PO, and a sensor element for sensing a parameter of interest, the sensor element coupling the first and second POs.
G02F 1/39 - Non-linear optics for parametric generation or amplification of light, infrared, or ultraviolet waves
G01N 21/17 - Systems in which incident light is modified in accordance with the properties of the material investigated
G01N 29/00 - Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic wavesVisualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
H03B 17/00 - Generation of oscillations using a radiation source and a detector
H01S 3/082 - Construction or shape of optical resonators or components thereof comprising three or more reflectors defining a plurality of resonators, e.g. for mode selection or suppression
G01S 7/481 - Constructional features, e.g. arrangements of optical elements
H01S 3/094 - Processes or apparatus for excitation, e.g. pumping using optical pumping by coherent light
H03B 15/00 - Generation of oscillations using galvano-magnetic devices, e.g. Hall-effect devices, devices using spin transfer effects, devices using giant magnetoresistance, or using super-conductivity effects
Described herein are photonic crystals comprising a plurality of substantially uniform zein particles. The photonic crystals can be fabricated by assembling the plurality of substantially uniform zein particles into one or more ordered and periodic structures that generate structural color. Also described herein are methods of using the photonic crystals described herein, e.g., as colorants in consumer products, such as food, drugs and/or cosmetics.
C09B 67/48 - Crystalline modifications of pigments or dyestuff
G02B 1/118 - Anti-reflection coatings having sub-optical wavelength surface structures designed to provide an enhanced transmittance, e.g. moth-eye structures
