Abstract

The present invention relates to a novel anti-PTK7, protein tyrosine kinase 7, antibody and derivatives thereof. The antibody and/or derivatives can be used for therapy and/or imaging, diagnosis and/or immunostaining.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
• A61K 51/10 - Antibodies or immunoglobulinsFragments thereof
• C07K 16/44 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere
• A61K 39/00 - Medicinal preparations containing antigens or antibodies

Abstract

The present invention relates to pharmaceutical compositions comprising a therapeutically relevant amount of alpha emitting radionuclides, for use in the treatment of cancer, and specifically where the individual has received cytoreductive surgery of one or more peritoneal tumor(s) prior to the administration of the pharmaceutical composition.

IPC Classes  ?

• A61K 51/12 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes
• A61P 35/00 - Antineoplastic agents
• A61K 51/02 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier

Abstract

The present disclosure relates to a particle comprising a degradable compound, a radionuclide, and a phosphorus containing additive. Phosphorus containing additives, such as phosphonates, have the unique ability to control the size of particles for medical applications. The applications allow for use of the particles as medicaments and for imaging, especially within the field of cancer.

IPC Classes  ?

• A61K 51/12 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes
• A61K 51/04 - Organic compounds

Abstract

The present invention related to a combination of radium-224 (224Ra) and/or progeny of 224Ra, and a DNA repair inhibitor for use in the treatment of cancer. The DNA repair inhibitor can for example be a poly (ADP-ribose) polymerase inhibitor (PARPi), a MGMT inhibitor, a DNA-dependent protein kinase inhibitor (DNA-PK inhibitor), an ataxia telangiectasia and Rad3-related (ATR) kinase inhibitor, an ataxia telangiectasia mutated (ATM) kinase inhibitor, a Wee1 kinase inhibitor, or a checkpoint kinase 1 and 2 (CHK 1/2) inhibitor. The radium-224 (224Ra) and/or progeny of 224Ra can be comprised in nano- and/or micro sized particles.

IPC Classes  ?

• A61K 51/12 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes
• A61K 33/24 - Heavy metalsCompounds thereof
• A61K 31/5025 - PyridazinesHydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
• A61K 31/502 - PyridazinesHydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
• A61K 31/454 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
• A61K 31/55 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
• A61P 35/00 - Antineoplastic agents

Abstract

The present disclosure relates to a particle comprising a degradable compound, a radionuclide, and a phosphorus containing additive. Phosphorus containing additives, such as phosphonates, have the unique ability to control the size of particles for medical applications. The applications allow for use of the particles as medicaments and for imaging, especially within the field of cancer.

IPC Classes  ?

• A61K 51/12 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes
• A61K 51/02 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier
• A61P 35/00 - Antineoplastic agents

Abstract

The present invention related to a combination of radium-224 (224Ra) and/or progeny of 224Ra, and a DNA repair inhibitor for use in the treatment of cancer. The DNA repair inhibitor can for example be a poly (ADP-ribose) polymerase inhibitor (PARPi), a MGMT inhibitor, a DNA-dependent protein kinase inhibitor (DNA-PK inhibitor), an ataxia telangiectasia and Rad3-related (ATR) kinase inhibitor, an ataxia telangiectasia mutated (ATM) kinase inhibitor, a Wee1 kinase inhibitor, or a checkpoint kinase 1 and 2 (CHK1/2) inhibitor. The radium-224 (224Ra) and/or progeny of 224Ra can be comprised in nano- and/or micro sized particles.

IPC Classes  ?

• A61K 31/166 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon atom of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
• A61K 31/4184 - 1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
• A61K 31/454 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• A61K 31/501 - PyridazinesHydrogenated pyridazines not condensed and containing further heterocyclic rings
• A61K 31/502 - PyridazinesHydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
• A61K 31/5025 - PyridazinesHydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
• A61K 31/551 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogens as ring hetero atoms, e.g. clozapine, dilazep
• A61K 31/5517 - 1,4-Benzodiazepines, e.g. diazepam condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
• A61K 33/24 - Heavy metalsCompounds thereof
• A61P 35/00 - Antineoplastic agents
• A61K 51/00 - Preparations containing radioactive substances for use in therapy or testing in vivo

Abstract

The invention relates to chimeric antigen receptor (CAR) specific to p80 and CD146, vectors encoding the same, and recombinant T cells comprising the p80 or CD146 CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a p80 or CD146 binding domain.

IPC Classes  ?

• C07K 16/30 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells

Goods & Services

Pharmaceuticals and veterinary preparations; sanitary preparations for medical purposes; dietetic food and substances adapted for medical or veterinary use, food for babies; dietary supplements for humans and animals; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides; preparations for treatment of cancer; preparations for treatment of tumours; therapeutic preparations for treatment of micrometastases; anti-cancer preparations for injections; radioactive preparations for radiation treatment; radioactive medicines; diagnostic preparations. Surgical, medical, dental and veterinary apparatus and instruments; artificial limbs, eyes and teeth; orthopaedic articles; suture materials; apparatus and instruments for injection of pharmaceuticals; apparatus and instruments for dosing of pharmaceuticals; parts and accesories for all the aforementioned goods. Scientific and technological services and research and design relating thereto; industrial analysis and research services; design and development of computer hardware and software; research and development of pharmaceuticals, preparations for cancer treatment, preparations for treatment of tumours, therapeutic preparations for treatment of micrometastases, anti-cancer preparations for injection, radioactive preparations for radiation treatment, readioactive pharmaceuticals and diagnostic preparations; design and development of diagnostical equipment; research and development within diagnostic preparations; design and development of medical technique; research and development for the pharmaceutical industry; consultancy and information related to the aforesaid services. Medical services; veterinary services.

Goods & Services

Pharmaceutical and veterinary preparations; sanitary preparations for medical purposes; dietetic food and substances adapted for medical or veterinary use, food for babies; dietary supplements for humans and animals; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides; preparations for treatment of cancer; preparations for treatment of tumours; therapeutic preparations for treatment of micrometastases; anti-cancer preparations for injections; radioactive preparations for radiation treatment; radioactive medicines; diagnostic preparations. Surgical, medical, dental and veterinary apparatus and instruments; artificial limbs, eyes and teeth; orthopaedic articles; suture materials; apparatus and instruments for injection of pharmaceuticals; apparatus and instruments for dosing of pharmaceuticals; parts and accessories for all the aforementioned goods.

Goods & Services

(1) Pharmaceutical and veterinary preparations for the treatment of cancer; pharmaceutical and veterinary preparations for suppressing tumours; pharmaceutical and veterinary antibodies; pharmaceutical and veterinary immune- and radio immunotherapeutic preparations; plasters, namely, medical plasters and surgical plasters; materials for dressings, namely, gauze for dressings, bandages for dressings; material for stopping teeth, dental wax; all-purpose disinfectants; preparations for destroying vermin; fungicides, herbicides; therapeutic preparations for the treatment for metastatic cancer; pharmaceutical preparations for injections for the purpose of cancer treatment; pharmaceutical preparations and medicines for use in radiation therapy; diagnostic preparations for medical laboratory use, diagnostic preparations for the detection of cancer, diagnostic reagents for veterinary purposes (2) Surgical instruments, medical instruments, dental instruments, and veterinary instruments for use in cancer treatment and radiological equipment for medical purposes; artificial limbs, eyes and teeth; suture materials; instruments for injection of pharmaceuticals; medical devices for dosimetry purposes of pharmaceuticals in the field of radiotherapy (1) Treatment of materials for use in production of pharmaceutical preparations; production and custom manufacturing of pharmaceuticals; production and custom manufacturing of preparations for cancer treatment, preparations for treatment of tumours, therapeutic preparations for treatment of micrometastases, anti-cancer preparations for injection, radioactive preparations for radiation treatment, radioactive pharmaceuticals and diagnostical preparations (2) Scientific research in the field of cancer treatment; research on the subject of pharmaceuticals; medical research services; design and development of computer hardware and software; research and development of pharmaceuticals, preparations for cancer treatment, preparations for treatment of tumours, therapeutic preparations for treatment of micrometastases, anti-cancer preparations for injection, radioactive preparations for radiation treatment, radioactive pharmaceuticals and diagnostic preparations; design and development of medical diagnostic apparatus for cancer screening, diagnosis and treatment; research and development of diagnostic preparations for medical purposes for cancer screening, diagnosis and treatment; design and development of medical technique; research and development for the pharmaceutical industry; providing medical and scientific research information in the field of cancer screening, diagnosis and treatment (3) Medical analysis services for the diagnosis of cancer; medical diagnostic services; medical services in the field of oncology; veterinary services; consultancy relating to cancer screening, diagnosis and treatment

Goods & Services

(1) Pharmaceutical and veterinary preparations for the treatment of cancer and for suppressing tumours; sanitary preparations for medical purposes, namely, disinfecting preparations for hands, feet, skin and body; food for babies; dietary supplements for general health and well-being, vitamin and mineral dietary supplements for humans and animals; plasters, namely, medical plasters and surgical plasters; materials for dressings, namely, gauze for dressings, bandages for dressings; dental wax; all-purpose disinfectants; preparations for destroying vermin; fungicides, herbicides; anti-cancer preparations; pharmaceutical preparations for treating malignant tumours; therapeutic preparations for the treatment for metastatic cancer; anti-cancer preparations for injections; pharmaceutical preparations and medicines for use in radiation therapy treatment of cancer; diagnostic preparations for medical laboratory use, diagnostic reagents for medical diagnostic use, diagnostic preparations for medical purposes for detecting tumours (2) Surgical instruments, medical instruments, dental instruments, and veterinary instruments for use in cancer treatment and radiological equipment for medical purposes; artificial limbs, eyes and teeth; suture materials; instruments for injection of pharmaceuticals; apparatus and instruments for dosing of pharmaceuticals, namely, dosimeter

Goods & Services

Pharmaceutical and veterinary preparations for the treatment of cancer; sanitary preparations for medical purposes; dietary supplements for humans and animals; medial plasters, materials for dressings in the form of wound dressing and bandages for wound dressing; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides; preparations for treatment of cancer; preparations for treatment of tumours; therapeutic preparations for treatment of micrometastases; anti-cancer preparations for injections; radioactive preparations for radiation treatment; radioactive medicines for cancer treatment; diagnostic preparations for medical purposes [ Surgical instruments; medical apparatus and instruments for use in cancer treatment; artificial limbs, eyes and teeth; suture materials; apparatus and instruments for injection of pharmaceuticals; apparatus and instruments for dosing of pharmaceuticals ]

Goods & Services

Scientific and technological services, namely, research and design in the field of cancer treatment; Industrial research in the field of cancer treatment; [ design and development of computer hardware and software; ] research and development of pharmaceuticals, preparations for cancer treatment, preparations for treatment of tumors, therapeutic preparations for treatment of micro metastases, anti-cancer preparations for injection, radioactive preparations for radiation treatment, radioactive pharmaceuticals and diagnostic preparations [ ; design and development of medical diagnostical equipment; research and development of medical diagnostic preparations; design and development of medical technique; research and development for the pharmaceutical industry; consulting services in the field of pharmaceutical research and development ] [ Medical services; veterinary services ] Pharmaceutical and veterinary preparations for the treatment of cancer; [ sanitary preparations for medical purposes; dietary supplements for humans and animals; medical plasters, materials for dressings in the form of wound dressing and bandages for dressing; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides; ] preparations for treatment of cancer; preparations for treatment of tumors; therapeutic preparations for treatment of micro metastases; anti-cancer preparations for injections; radioactive preparations for radiation treatment; radioactive medicines for cancer treatment [ ; diagnostic preparations for medical purposes ] [ Surgical instruments, medical apparatus and instruments for use in cancer treatment; artificial limbs, eyes and teeth; suture materials; apparatus and instruments for injection of pharmaceuticals; apparatus and instruments for dosing of pharmaceuticals ]

Abstract

The present invention relates to a particle or pharmaceutical composition comprising one, more particles or a suspension of same or different particles comprising a degradable compound and an alpha emitting radionuclide and/or a radionuclide generating alpha emitting daughter. A particle comprising CaCO3, the alpha emitting radionuclide 224Ra, and a 224Ra radionuclide progeny is in particular disclosed. The particles are beneficial for use in the treatment of cancer.

IPC Classes  ?

• A61K 51/02 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier
• A61K 51/10 - Antibodies or immunoglobulinsFragments thereof
• A61K 51/12 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes
• A61P 35/00 - Antineoplastic agents
• A61K 103/00 - Radioactive metals

Abstract

The present invention relates to a particle or pharmaceutical composition comprising one, more particles or a suspension of same or different particles comprising a degradable compound and an alpha emitting radionuclide and/or a radionuclide generating alpha emitting daughter. The particles are beneficial for use in the treatment of cancer.

IPC Classes  ?

• A61K 51/02 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier
• A61K 51/12 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes
• A61K 51/10 - Antibodies or immunoglobulinsFragments thereof
• C01F 11/18 - Carbonates

Abstract

The present invention relates to a novel anti-CD146 antibody and derivatives thereof. The antibody and/or derivatives can be used for therapy and/or imaging, diagnosis and/or immunostaining.

IPC Classes  ?

• A61K 51/10 - Antibodies or immunoglobulinsFragments thereof
• C07K 16/30 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
• C07K 16/00 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies
• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61K 39/00 - Medicinal preparations containing antigens or antibodies

Abstract

The present invention relates to a novel anti-CD146 antibody and derivatives thereof. The antibody and/or derivatives can be used for therapy and/or imaging, diagnosis and/or immunostaining.

IPC Classes  ?

• A61K 51/10 - Antibodies or immunoglobulinsFragments thereof
• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• C07K 16/30 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
• A61P 35/00 - Antineoplastic agents