Abrégé

The present invention relates to a novel anti-PTK7, protein tyrosine kinase 7, antibody and derivatives thereof. The antibody and/or derivatives can be used for therapy and/or imaging, diagnosis and/or immunostaining.

Classes IPC  ?

• C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
• A61K 47/68 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un anticorps, une immunoglobuline ou son fragment, p. ex. un fragment Fc
• A61K 51/10 - Anticorps ou immunoglobulinesLeurs fragments
• C07K 16/44 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel non prévu ailleurs
• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps

Abrégé

The present invention relates to pharmaceutical compositions comprising a therapeutically relevant amount of alpha emitting radionuclides, for use in the treatment of cancer, and specifically where the individual has received cytoreductive surgery of one or more peritoneal tumor(s) prior to the administration of the pharmaceutical composition.

Classes IPC  ?

• A61K 51/12 - Préparations contenant des substances radioactives utilisées pour la thérapie ou pour l'examen in vivo caractérisées par un aspect physique particulier, p. ex. émulsion, microcapsules, liposomes
• A61P 35/00 - Agents anticancéreux
• A61K 51/02 - Préparations contenant des substances radioactives utilisées pour la thérapie ou pour l'examen in vivo caractérisées par le support

Abrégé

The present disclosure relates to a particle comprising a degradable compound, a radionuclide, and a phosphorus containing additive. Phosphorus containing additives, such as phosphonates, have the unique ability to control the size of particles for medical applications. The applications allow for use of the particles as medicaments and for imaging, especially within the field of cancer.

Classes IPC  ?

• A61K 51/12 - Préparations contenant des substances radioactives utilisées pour la thérapie ou pour l'examen in vivo caractérisées par un aspect physique particulier, p. ex. émulsion, microcapsules, liposomes
• A61K 51/04 - Composés organiques

Abrégé

The present invention related to a combination of radium-224 (224Ra) and/or progeny of 224Ra, and a DNA repair inhibitor for use in the treatment of cancer. The DNA repair inhibitor can for example be a poly (ADP-ribose) polymerase inhibitor (PARPi), a MGMT inhibitor, a DNA-dependent protein kinase inhibitor (DNA-PK inhibitor), an ataxia telangiectasia and Rad3-related (ATR) kinase inhibitor, an ataxia telangiectasia mutated (ATM) kinase inhibitor, a Wee1 kinase inhibitor, or a checkpoint kinase 1 and 2 (CHK 1/2) inhibitor. The radium-224 (224Ra) and/or progeny of 224Ra can be comprised in nano- and/or micro sized particles.

Classes IPC  ?

• A61K 51/12 - Préparations contenant des substances radioactives utilisées pour la thérapie ou pour l'examen in vivo caractérisées par un aspect physique particulier, p. ex. émulsion, microcapsules, liposomes
• A61K 33/24 - Métaux lourdsLeurs composés
• A61K 31/5025 - PyridazinesPyridazines hydrogénées condensées en ortho ou en péri avec des systèmes hétérocycliques
• A61K 31/502 - PyridazinesPyridazines hydrogénées condensées en ortho ou en péri avec des systèmes carbocycliques, p. ex. cinnoline, phtalazine
• A61K 31/454 - Pipéridines non condensées, p. ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un cycle à cinq chaînons avec l'azote comme hétéro-atome du cycle, p. ex. pimozide, dompéridone
• A61K 31/55 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à sept chaînons, p. ex. azélastine, pentylènetétrazole
• A61P 35/00 - Agents anticancéreux

Abrégé

The present disclosure relates to a particle comprising a degradable compound, a radionuclide, and a phosphorus containing additive. Phosphorus containing additives, such as phosphonates, have the unique ability to control the size of particles for medical applications. The applications allow for use of the particles as medicaments and for imaging, especially within the field of cancer.

Classes IPC  ?

• A61K 51/12 - Préparations contenant des substances radioactives utilisées pour la thérapie ou pour l'examen in vivo caractérisées par un aspect physique particulier, p. ex. émulsion, microcapsules, liposomes
• A61K 51/02 - Préparations contenant des substances radioactives utilisées pour la thérapie ou pour l'examen in vivo caractérisées par le support
• A61P 35/00 - Agents anticancéreux

Abrégé

The present invention related to a combination of radium-224 (224Ra) and/or progeny of 224Ra, and a DNA repair inhibitor for use in the treatment of cancer. The DNA repair inhibitor can for example be a poly (ADP-ribose) polymerase inhibitor (PARPi), a MGMT inhibitor, a DNA-dependent protein kinase inhibitor (DNA-PK inhibitor), an ataxia telangiectasia and Rad3-related (ATR) kinase inhibitor, an ataxia telangiectasia mutated (ATM) kinase inhibitor, a Wee1 kinase inhibitor, or a checkpoint kinase 1 and 2 (CHK1/2) inhibitor. The radium-224 (224Ra) and/or progeny of 224Ra can be comprised in nano- and/or micro sized particles.

Classes IPC  ?

• A61K 31/166 - Amides, p. ex. acides hydroxamiques ayant des cycles aromatiques, p. ex. colchicine, aténolol, progabide ayant l'atome de carbone d'un groupe carboxamide lié directement au cycle aromatique, p. ex. procaïnamide, procarbazine, métoclopramide, labétalol
• A61K 31/4184 - 1,3-Diazoles condensés avec des carbocycles, p. ex. benzimidazoles
• A61K 31/454 - Pipéridines non condensées, p. ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un cycle à cinq chaînons avec l'azote comme hétéro-atome du cycle, p. ex. pimozide, dompéridone
• A61K 31/496 - Pipérazines non condensées contenant d'autres hétérocycles, p. ex. rifampine, thiothixène ou sparfloxacine
• A61K 31/501 - PyridazinesPyridazines hydrogénées non condensées et contenant d'autres hétérocycles
• A61K 31/502 - PyridazinesPyridazines hydrogénées condensées en ortho ou en péri avec des systèmes carbocycliques, p. ex. cinnoline, phtalazine
• A61K 31/5025 - PyridazinesPyridazines hydrogénées condensées en ortho ou en péri avec des systèmes hétérocycliques
• A61K 31/551 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à sept chaînons, p. ex. azélastine, pentylènetétrazole ayant deux atomes d'azote comme hétéro-atomes d'un cycle, p. ex. clozapine, dilazèpe
• A61K 31/5517 - 1,4-Benzodiazépines, p. ex. diazépam condensées avec des cycles à cinq chaînons ayant l'azote comme hétéro-atome d'un cycle, p. ex. imidazobenzodiazépines, triazolam
• A61K 33/24 - Métaux lourdsLeurs composés
• A61P 35/00 - Agents anticancéreux
• A61K 51/00 - Préparations contenant des substances radioactives utilisées pour la thérapie ou pour l'examen in vivo

Abrégé

The invention relates to chimeric antigen receptor (CAR) specific to p80 and CD146, vectors encoding the same, and recombinant T cells comprising the p80 or CD146 CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a p80 or CD146 binding domain.

Classes IPC  ?

• C07K 16/30 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire provenant de cellules de tumeurs

Produits et services

Pharmaceuticals and veterinary preparations; sanitary preparations for medical purposes; dietetic food and substances adapted for medical or veterinary use, food for babies; dietary supplements for humans and animals; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides; preparations for treatment of cancer; preparations for treatment of tumours; therapeutic preparations for treatment of micrometastases; anti-cancer preparations for injections; radioactive preparations for radiation treatment; radioactive medicines; diagnostic preparations. Surgical, medical, dental and veterinary apparatus and instruments; artificial limbs, eyes and teeth; orthopaedic articles; suture materials; apparatus and instruments for injection of pharmaceuticals; apparatus and instruments for dosing of pharmaceuticals; parts and accesories for all the aforementioned goods. Scientific and technological services and research and design relating thereto; industrial analysis and research services; design and development of computer hardware and software; research and development of pharmaceuticals, preparations for cancer treatment, preparations for treatment of tumours, therapeutic preparations for treatment of micrometastases, anti-cancer preparations for injection, radioactive preparations for radiation treatment, readioactive pharmaceuticals and diagnostic preparations; design and development of diagnostical equipment; research and development within diagnostic preparations; design and development of medical technique; research and development for the pharmaceutical industry; consultancy and information related to the aforesaid services. Medical services; veterinary services.

Produits et services

Pharmaceutical and veterinary preparations; sanitary preparations for medical purposes; dietetic food and substances adapted for medical or veterinary use, food for babies; dietary supplements for humans and animals; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides; preparations for treatment of cancer; preparations for treatment of tumours; therapeutic preparations for treatment of micrometastases; anti-cancer preparations for injections; radioactive preparations for radiation treatment; radioactive medicines; diagnostic preparations. Surgical, medical, dental and veterinary apparatus and instruments; artificial limbs, eyes and teeth; orthopaedic articles; suture materials; apparatus and instruments for injection of pharmaceuticals; apparatus and instruments for dosing of pharmaceuticals; parts and accessories for all the aforementioned goods.

Produits et services

(1) Pharmaceutical and veterinary preparations for the treatment of cancer; pharmaceutical and veterinary preparations for suppressing tumours; pharmaceutical and veterinary antibodies; pharmaceutical and veterinary immune- and radio immunotherapeutic preparations; plasters, namely, medical plasters and surgical plasters; materials for dressings, namely, gauze for dressings, bandages for dressings; material for stopping teeth, dental wax; all-purpose disinfectants; preparations for destroying vermin; fungicides, herbicides; therapeutic preparations for the treatment for metastatic cancer; pharmaceutical preparations for injections for the purpose of cancer treatment; pharmaceutical preparations and medicines for use in radiation therapy; diagnostic preparations for medical laboratory use, diagnostic preparations for the detection of cancer, diagnostic reagents for veterinary purposes (2) Surgical instruments, medical instruments, dental instruments, and veterinary instruments for use in cancer treatment and radiological equipment for medical purposes; artificial limbs, eyes and teeth; suture materials; instruments for injection of pharmaceuticals; medical devices for dosimetry purposes of pharmaceuticals in the field of radiotherapy (1) Treatment of materials for use in production of pharmaceutical preparations; production and custom manufacturing of pharmaceuticals; production and custom manufacturing of preparations for cancer treatment, preparations for treatment of tumours, therapeutic preparations for treatment of micrometastases, anti-cancer preparations for injection, radioactive preparations for radiation treatment, radioactive pharmaceuticals and diagnostical preparations (2) Scientific research in the field of cancer treatment; research on the subject of pharmaceuticals; medical research services; design and development of computer hardware and software; research and development of pharmaceuticals, preparations for cancer treatment, preparations for treatment of tumours, therapeutic preparations for treatment of micrometastases, anti-cancer preparations for injection, radioactive preparations for radiation treatment, radioactive pharmaceuticals and diagnostic preparations; design and development of medical diagnostic apparatus for cancer screening, diagnosis and treatment; research and development of diagnostic preparations for medical purposes for cancer screening, diagnosis and treatment; design and development of medical technique; research and development for the pharmaceutical industry; providing medical and scientific research information in the field of cancer screening, diagnosis and treatment (3) Medical analysis services for the diagnosis of cancer; medical diagnostic services; medical services in the field of oncology; veterinary services; consultancy relating to cancer screening, diagnosis and treatment

Produits et services

(1) Pharmaceutical and veterinary preparations for the treatment of cancer and for suppressing tumours; sanitary preparations for medical purposes, namely, disinfecting preparations for hands, feet, skin and body; food for babies; dietary supplements for general health and well-being, vitamin and mineral dietary supplements for humans and animals; plasters, namely, medical plasters and surgical plasters; materials for dressings, namely, gauze for dressings, bandages for dressings; dental wax; all-purpose disinfectants; preparations for destroying vermin; fungicides, herbicides; anti-cancer preparations; pharmaceutical preparations for treating malignant tumours; therapeutic preparations for the treatment for metastatic cancer; anti-cancer preparations for injections; pharmaceutical preparations and medicines for use in radiation therapy treatment of cancer; diagnostic preparations for medical laboratory use, diagnostic reagents for medical diagnostic use, diagnostic preparations for medical purposes for detecting tumours (2) Surgical instruments, medical instruments, dental instruments, and veterinary instruments for use in cancer treatment and radiological equipment for medical purposes; artificial limbs, eyes and teeth; suture materials; instruments for injection of pharmaceuticals; apparatus and instruments for dosing of pharmaceuticals, namely, dosimeter

Produits et services

Pharmaceutical and veterinary preparations for the treatment of cancer; sanitary preparations for medical purposes; dietary supplements for humans and animals; medial plasters, materials for dressings in the form of wound dressing and bandages for wound dressing; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides; preparations for treatment of cancer; preparations for treatment of tumours; therapeutic preparations for treatment of micrometastases; anti-cancer preparations for injections; radioactive preparations for radiation treatment; radioactive medicines for cancer treatment; diagnostic preparations for medical purposes [ Surgical instruments; medical apparatus and instruments for use in cancer treatment; artificial limbs, eyes and teeth; suture materials; apparatus and instruments for injection of pharmaceuticals; apparatus and instruments for dosing of pharmaceuticals ]

Produits et services

Scientific and technological services, namely, research and design in the field of cancer treatment; Industrial research in the field of cancer treatment; [ design and development of computer hardware and software; ] research and development of pharmaceuticals, preparations for cancer treatment, preparations for treatment of tumors, therapeutic preparations for treatment of micro metastases, anti-cancer preparations for injection, radioactive preparations for radiation treatment, radioactive pharmaceuticals and diagnostic preparations [ ; design and development of medical diagnostical equipment; research and development of medical diagnostic preparations; design and development of medical technique; research and development for the pharmaceutical industry; consulting services in the field of pharmaceutical research and development ] [ Medical services; veterinary services ] Pharmaceutical and veterinary preparations for the treatment of cancer; [ sanitary preparations for medical purposes; dietary supplements for humans and animals; medical plasters, materials for dressings in the form of wound dressing and bandages for dressing; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides; ] preparations for treatment of cancer; preparations for treatment of tumors; therapeutic preparations for treatment of micro metastases; anti-cancer preparations for injections; radioactive preparations for radiation treatment; radioactive medicines for cancer treatment [ ; diagnostic preparations for medical purposes ] [ Surgical instruments, medical apparatus and instruments for use in cancer treatment; artificial limbs, eyes and teeth; suture materials; apparatus and instruments for injection of pharmaceuticals; apparatus and instruments for dosing of pharmaceuticals ]

Abrégé

The present invention relates to a particle or pharmaceutical composition comprising one, more particles or a suspension of same or different particles comprising a degradable compound and an alpha emitting radionuclide and/or a radionuclide generating alpha emitting daughter. A particle comprising CaCO3, the alpha emitting radionuclide 224Ra, and a 224Ra radionuclide progeny is in particular disclosed. The particles are beneficial for use in the treatment of cancer.

Classes IPC  ?

• A61K 51/02 - Préparations contenant des substances radioactives utilisées pour la thérapie ou pour l'examen in vivo caractérisées par le support
• A61K 51/10 - Anticorps ou immunoglobulinesLeurs fragments
• A61K 51/12 - Préparations contenant des substances radioactives utilisées pour la thérapie ou pour l'examen in vivo caractérisées par un aspect physique particulier, p. ex. émulsion, microcapsules, liposomes
• A61P 35/00 - Agents anticancéreux
• A61K 103/00 - Métaux radioactifs

Abrégé

The present invention relates to a particle or pharmaceutical composition comprising one, more particles or a suspension of same or different particles comprising a degradable compound and an alpha emitting radionuclide and/or a radionuclide generating alpha emitting daughter. The particles are beneficial for use in the treatment of cancer.

Classes IPC  ?

• A61K 51/02 - Préparations contenant des substances radioactives utilisées pour la thérapie ou pour l'examen in vivo caractérisées par le support
• A61K 51/12 - Préparations contenant des substances radioactives utilisées pour la thérapie ou pour l'examen in vivo caractérisées par un aspect physique particulier, p. ex. émulsion, microcapsules, liposomes
• A61K 51/10 - Anticorps ou immunoglobulinesLeurs fragments
• C01F 11/18 - Carbonates

Abrégé

The present invention relates to a novel anti-CD146 antibody and derivatives thereof. The antibody and/or derivatives can be used for therapy and/or imaging, diagnosis and/or immunostaining.

Classes IPC  ?

• A61K 51/10 - Anticorps ou immunoglobulinesLeurs fragments
• C07K 16/30 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire provenant de cellules de tumeurs
• C07K 16/00 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux
• C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps

Abrégé

The present invention relates to a novel anti-CD146 antibody and derivatives thereof. The antibody and/or derivatives can be used for therapy and/or imaging, diagnosis and/or immunostaining.

Classes IPC  ?

• A61K 51/10 - Anticorps ou immunoglobulinesLeurs fragments
• C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
• C07K 16/30 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire provenant de cellules de tumeurs
• A61P 35/00 - Agents anticancéreux