The United States of America, as represented by the Secretary, Department of Health and Human Services

United States of America

 
Total IP 2,838
Total IP Rank # 428
IP Activity Score 3.8/5.0    1,476
IP Activity Rank # 491

Patents

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Last Patent 2025 - Kinase inhibitors
First Patent 1982 - Method for reducing toxic effect...

Latest Inventions, Goods, Services

2024 Invention Codon-optimized human npc1 genes for the treatment of niemann-pick type c1 deficiency and related...
Invention Dopamine d3 receptor selective antagonists/partial agonists and uses thereof. Disclosed herein a...
Invention Identification of novel sequences of the ervmer34-1 human endogenous retroviral sequence family, ...
Invention Kinase inhibitors. Disclosed is a class of kinase inhibitors of formula (I) or formula (II). Rela...
Invention 2b serotonin receptor antagonists, pharmaceutical compositions thereof, and methods of use thereo...
Invention Fully human monoclonal antibodies and chimeric antigen receptors against cd276 for the treatment ...
Invention Humanized 40h3 antibody. e.ge.g., humanized monoclonal antibodies and antigen binding fragments) ...
Invention Uses of iron chelators for treating stuttering. Provided herein are uses of iron chelators to tre...
Invention Potent and selective dopamine d3 receptor antagonists. 33 receptor modulators, inclusive of antag...
Invention Shipping container for system supporting live cells. A shipping container for the support and shi...
Invention Genetically detoxified mutant of neisseria and outer membrane vesicle (omv) vaccine. Disclosed ar...
Invention Novel malaria vaccine comprising ama1 and ron2 antigens. Plasmodium yoeliiPlasmodium falciparumPl...
Invention T cell receptors targeting ras with g12d, g12r, or g12v mutation. Disclosed are isolated or purif...
Invention Epidithiodiketopiperazine analogs and methods of use. Epidithiodiketopiperazine (ETP) analogs and...
Invention Method and apparatus for cryogenic-electron microscopy sample preparation. An apparatus for prepa...
Invention Formulations and methods for the prevention and treatment of tumor metastasis and tumorigenesis. ...
Invention Vaccine for cats to block toxoplasma oocyst shedding and transmission. Apicomplexa or EuglenozoaT...
Invention Hiv-1 envelope triple tandem trimers and their use. Immunogens comprising a recombinant HIV-1 Env...
Invention Copiparvovirus genetic vector platform. In a first aspect, the invention provides a genetic vecto...
Invention Tyrosinase gene therapy for oculocutaneous albinism type 1a. TyrosinaseBESTROPHINVMD2TyrosinaseTy...
Invention Human monoclonal antibodies that target the rh5 complex of blood-stage plasmodium falciparum. P. ...
Invention Recombinant murine pneumonia virus expressing severe acute respiratory syndrome coronavirus 2 (sa...
Invention Single domain antibodies that specifically bind the s2 subunit of sars-cov-2 spike protein and co...
Invention Treatment of hypoparathyroidism using triphenyl calcilytic compounds. The present disclosure prov...
Invention Systems and methods for multichannel individualized stimulation therapy. Methods and systems are ...
Invention Synthetic mmab genes and aav vectors to treat cobalamin b deficiency. synMMABsynMMABsynMMAB polyn...
Invention Systems and methods for patterned multi-slice excitation in magnetic resonance imaging. Various m...
Invention Methods of preparing an isolated population of dendritic cells and methods of treating cancer usi...
Invention 1-thioxo-2,4-dihydrothieno[2,3-e][1,2,4]triazolo[4,3-a]pyrimidin-5(1 h)-one derivatives as allost...
Invention Methods for enhancing the immunogenicity of cellular vaccines. The present disclosure provides en...
Invention Enzymatic radiosynthesis of deoxy-[18f]fluorocellobiose and deoxy-[18f]fluorocellotriose. Enzymat...
Invention T cell receptors targeting y220c or r175h mutation in p53. Disclosed are isolated or purified T c...
Invention Methods for treatment of age-related macular degeneration. Methods are disclosed for treating or ...
Invention Methods for producing stable human chondroctyes and their use for promoting cartillage growth and...
Invention Devices and methods. The present invention provides devices and methods for electroporation. Embo...
Invention System and protocol for monitoring pregnancy health. The disclosure provides systems and a protoc...
Invention Detection of hepatitis c virus ribonucleic acid from whole blood using reverse transcription loop...
Invention Dual-target mu opioid and dopamine d3 receptors ligands preparation and use thereof. 3333R antago...
Invention Composition for preventing or treating systemic capillary leak syndrome. The present invention pe...
Invention Mutant ara h 2 and ara h 6 proteins and uses thereof. Provided herein are hypoallergenic mutant A...
Invention Recombinant adeno-associated virus vectors lacking an immunodominant t cell epitope and use there...
Invention Systems and methods for introducing samples to open port interface. A method of processing a sam...
Invention Methods of preparing anti-human papillomavirus antigen t cells. Disclosed are methods of prepari...
Invention Systems and methods for deep learning to detect retinal vasculitis on color fundus photographs of...
Invention Epstein-barr virus glycoprotein 42 immunogens for vaccination and antibody discovery. Modified Ep...
2023 Invention Fluorinated mu-opioid receptor agonists. The invention provides a fluorinated compound of Formula...
2022 Invention Aqp1 gene therapy to prevent radiation induced salivary hypofunction. Administration of aquapori...
2021 Invention Antibody-guided pcsk9-mimicking immunogens lacking 9-residue sequence overlap with human proteins...
Invention Exo vii inhibitor and quinolone antibiotic combination useful for treating bacterial infection. ...
Invention Therapeutics for the treatment of neurodegenerative disorders. Antisense oligonucleotides (ASOs)...