The United States of America, as represented by the Secretary, Department of Health and Human Services

United States of America

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Total IP 2,895
Total IP Rank # 432
IP Activity Score 3.8/5.0    1,307
IP Activity Rank # 550

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Last Patent 2025 - Corynebacterium mastitidis-deriv...
First Patent 1982 - Method for reducing toxic effect...

Latest Inventions, Goods, Services

2025 Invention Multidimensional mri signature for specific detection of traumatic brain injury in vivo. Multidi...
Invention Corynebacterium mastitidis-derived mycolates for treating barriers. The invention provides a comp...
Invention Antibodies against ev-d68. This disclosure provides antibodies that bind enteroviruses. In some a...
Invention Chimeric antigen receptors targeting fgfr4 and/or cd276 and use thereof for the treatment of canc...
Invention Modified piggybat transposition system and uses thereof. piggyBatpiggyBatpiggyBatpiggyBatpiggyBat...
Invention Multifunctional molecules binding to tcr and uses thereof. Provided herein are multifunctional mo...
Invention Acceleration of multidimensional magnetic resonance imaging (mri) acquisition via k-space partial...
Invention Potent fgfr4-targeted antibody-drug conjugates and their use for treating cancers expressing fgfr...
Invention S-hydroxychloroquine, optionally with tauroursodeoxycholic acid and/or 3,3'-diindolylmethane, for...
Invention Antigen binding polypeptides, polypeptide complexes and methods of use thereof. Disclosed are ant...
Invention Methods of detecting loss of heterozygosity and damaging mutations in immune-related genes in liq...
Invention Methods to identify and selectively expand tumor antigen-specific t cells. Disclosed are methods ...
Invention Radiolabeled glypican-3 (gpc3)-specific single domain antibody and use thereof as an imaging agen...
Invention Systems and methods for an augmented reality guidance system. Various embodiments of an augmented...
Invention Biomarkers for identifying cancer patients at high risk for chemotherapy-induced cardiotoxicity. ...
Invention Respiratory syncytial virus (rsv) g and f antibodies with high rsv-neutralizing potency. Highly p...
Invention T cell receptors targeting e545k or n345k mutation in pik3ca. Disclosed are isolated or purified ...
Invention Thermo-sensitive anti-fungal hydrogel compositions and methods of use. A hydrogel composition for...
Invention Self-assembling nanoparticles. The present disclosure relates to a vaccine comprising at least o...
Invention Single-domain antibodies and bispecific antibodies against hiv-1 and their use. Bispecific antibo...
Invention Systems for integrated imaging and multi-view augmented reality for surgical intervention. System...
Invention Treatment of cardiovascular disease with antxr1 antibodies. Disclosed herein are antibodies and a...
Invention Dynamic assessment of cellular metabolism through optical imaging and artificial intelligence tec...
Invention Monoclonal antibodies that bind the juxta-membrane region of mesothelin and uses thereof. Monoclo...
Invention Multi-well dialysis microplate. A sampling microplate or tray for conducting dialysis of a fluid ...
Invention Synthetic gba1 genes. coGBA1coGBA1GBA1GBA1 mutations, are also described.
Invention Predicting dna methylation and tumor types from histopathology. Disclosed herein are systems and ...
Invention Enhanced tumor reactivity of t cells lacking sit1, lax1, or trat1. SIT1, LAX1 TRAT1. TRAT1. Relat...
Invention Embolic microspheres. Functionalized embolic microspheres may be employed as a platform for radio...
Invention Novel compositions of matter comprising proteins that incorporate pfs230 or pvs230 domain 1 (pfs2...
Invention Use of lmo4 to bolster stemness and antitumor efficacy of t-cells. The present invention relates ...
2024 Invention Broadly neutralizing antibodies against sars-cov-2 and sars-cov variants. Disclosed are monoclona...
Invention N-methyltransferase and their therapeutic uses. NN-methyltransferase (NNMT) which have a triazolo...
Invention Oxabicycloheptanes for modulation of immune response. The present invention provides a method of...
Invention Rsv vaccine bearing a polynucleotide which is de-optimised and de-attenuated. Provided is a polyn...
Invention Systems and methods for clinical artificial intelligence with patient-reported multi-modal audio ...
Invention Quantitative optical coherence tomography angiography. By acquiring sequences of data associated ...
Invention Modified pigment epithelium-derived factor peptides and methods of use. Provided herein are compo...
Invention Broadly neutralizing influenza hemagglutinin stem-directed antibodies. Monoclonal antibodies and ...
Invention Development of broad-spectrum anti-opioid vaccines. Provided herein are vaccine compositions comp...
Invention Neutralizing and protective monoclonal antibodies against respiratory syncytial virus (rsv). Anti...
Invention Influenza neuraminidase active site proximity assay (naspa) for rapid profiling of inhibitory ant...
Invention Immunogenic compositions comprising full-length influenza virus neuraminidase protein subunits an...
Invention Dna methylation-based cancer diagnostics. Disclosed herein are methods for classifying a tumor us...
Invention Antibodies targeting cell surface deposited complement protein c3d and use thereof. Disclosed ar...
Invention Nanoparticle-hydrogel composite for nucleic acid molecule delivery. This disclosure provides nove...
2023 Invention Combination of angubindin-1 abd chemotherapy for the treatment of cns malignancies. The invention...
Invention Fused diazepines as agonists of the insulin-like 3 (insl3) peptide receptor rxfp2 and methods of ...
Invention Preparation of isotopically labeled ketoglutarates and methods of hyperpolarization through signa...
2017 Invention Compositions comprising pregnancy specific glycoproteins and methods of use thereof. The present ...