TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (Chine)
BEIJING CAS MICRONEEDLE TECHNOLOGY LTD. (Chine)
Inventeur(s)
Gao, Yunhua
Cheng, Aguo
Liu, Han
Zhang, Suohui
Abrégé
A method for nanocrystallizing cannabidiol, a nanocrystallized cannabidiol suspension prepared by the method and the use of nanocrystallized cannabidiol suspension. The method for nanocrystallizing cannabidiol comprises the following steps: dissolving cannabidiol in a good solvent to obtain a cannabidiol-good solvent solution; adding the cannabidiol-good solvent solution into an aqueous solution of a stabilizer; and performing ultrasonic treatment, and then performing rotary evaporation to remove the good solvent so as to obtain the nanocrystallized cannabidiol suspension, wherein the stabilizer is selected from one or more of poloxamer, Tween, polyoxyethylene alkyl ether, polyvinylpyrrolidone, hydroxypropyl methylcellulose and chitosan. According to the nanocrystallization method, by means of the technique of nanocrystallizing insoluble drugs, the particle size of insoluble drug cannabidiol is reduced, and the cannabidiol nanosuspension is obtained. In addition, the suspension has a high solid content of nanocrystallized cannabidiol, which realizes the solubilizing effect on cannabidiol.
A61K 47/26 - Hydrates de carbone, p. ex. polyols ou sucres alcoolisés, sucres aminés, acides nucléiques, mono-, di- ou oligosaccharidesLeurs dérivés, p. ex. polysorbates, esters d’acide gras de sorbitan ou glycyrrhizine
A61K 47/34 - Composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. polyesters, acides polyaminés, polysiloxanes, polyphosphazines, copolymères de polyalkylène glycol ou de poloxamères
A61K 47/32 - Composés macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. carbomères
A61K 47/36 - PolysaccharidesLeurs dérivés, p. ex. gommes, amidon, alginate, dextrine, acide hyaluronique, chitosane, inuline, agar-agar ou pectine
TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (Chine)
Beijing CAS Microneedle Technology Ltd. (Chine)
Inventeur(s)
Gao, Yunhua
Xing, Mengzhen
Abrégé
A hydrogel microneedle patch based on a three-dimensional framework structure is provided and includes a hydrogel microneedle. A raw material of the hydrogel microneedle includes polyvinyl alcohol and aqueous dispersion of acrylic resin. the hydrogel microneedle is obtained by uniformly mixing and molding of the aqueous dispersion of acrylic resin and the polyvinyl alcohol. The hydrogel microneedle patch has good strength, excellent swelling property and puncture property. In addition, a preparation method and an application of hydrogel microneedle patch are also provided.
A61M 37/00 - Autres appareils pour introduire des agents dans le corpsPercutanisation, c.-à-d. introduction de médicaments dans le corps par diffusion à travers la peau
TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (Chine)
BEIJING CAS MICRONEEDLE TECHNOLOGY LTD. (Chine)
Inventeur(s)
Gao, Yunhua
Wang, Baorui
Abrégé
Disclosed is a method for preparing a microneedle loaded with a drug microcrystal. The method comprises the following steps: providing a drug microcrystal with a particle size of 0.5-5 μm; dispersing the drug microcrystal in an aqueous solution of a microneedle matrix material, and removing bubbles to obtain a suspension; injecting the suspension onto a microneedle mold, making the suspension enter a pinhole unit by means of negative pressure, drying and demolding to obtain the microneedle loaded with the drug microcrystal. The method improves the stability of an insoluble drug in the microneedle and the like; meanwhile, the preparation method is simpler and easy for large-scale production and application. The method features good drug stability in the preparation process; the microneedle prepared using the method has a high drug loading capacity, and the microneedle can effectively pierce the stratum corneum of the skin, so that the drug microcrystal directly penetrates through the stratum corneum and is delivered to the subcutaneous tissue. Further disclosed is a microneedle loaded with a drug microcrystal prepared using the preparation method.
A61M 37/00 - Autres appareils pour introduire des agents dans le corpsPercutanisation, c.-à-d. introduction de médicaments dans le corps par diffusion à travers la peau
4.
HYDROGEL MICRONEEDLE PATCH BASED ON THREE-DIMENSIONAL SCAFFOLD STRUCTURE, PREPARATION METHOD THEREFOR, AND USE THEREOF
TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (Chine)
BEIJING CAS MICRONEEDLE TECHNOLOGY LTD. (Chine)
Inventeur(s)
Gao, Yunhua
Xing, Mengzhen
Abrégé
A hydrogel microneedle patch based on a three-dimensional scaffold structure, a preparation method for a microneedle patch, and a use thereof. The microneedle patch comprises microneedles; raw materials of the microneedles comprise polyvinyl alcohol and an aqueous acrylic resin dispersion; and the aqueous acrylic resin dispersion is evenly blended with polyvinyl alcohol and shaped to obtain the microneedles. The hydrogel microneedle patch has good strength and also has excellent swelling and penetration properties.
A61M 37/00 - Autres appareils pour introduire des agents dans le corpsPercutanisation, c.-à-d. introduction de médicaments dans le corps par diffusion à travers la peau
5.
METHOD FOR PREPARING GLYCOLATE BY ELECTROCATALYSIS OF ETHYLENE GLYCOL OR ELECTROCATALYTIC REFORMING OF WASTE PLASTIC PET
TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (Chine)
Inventeur(s)
Shi, Rui
Chen, Yong
Abrégé
Disclosed is a method for preparing glycolate by electrocatalysis of ethylene glycol or electrocatalytic reforming of waste plastic PET. The method for preparing glycolate by electrocatalytic reforming of waste plastic PET comprises the following steps: 1) dissolving waste plastic PET in an alkaline solution, carrying out a hydrolysis reaction, carrying out solid-liquid separation, and obtaining an alkaline electrolyte containing ethylene glycol; and 2) assembling an anode catalyst, a cathode catalyst, and the alkaline electrolyte containing ethylene glycol to form an electrolytic cell, applying a voltage for electrocatalytic reaction, the ethylene glycol being oxidized at an anode to generate glycolate, and water being reduced at a cathode to generate hydrogen. The present invention introduces, for the first time in the field, converting waste plastic PET into glycolate by means of electrocatalysis. The described method achieves the resource utilization and energy recovery of waste plastic PET, while also providing a novel approach for low-cost, large-scale production of glycolic acid.
TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (Chine)
Inventeur(s)
Gao, Yunhua
Zhou, Zequan
Zhang, Suohui
Abrégé
The present application discloses a coated microneedle with a multilayer structure, including a base, a needle tip on the base, and a functional coating. The functional coating includes a content including a water-soluble polymer material and an active ingredient, and a sustained-release layer wrapping the content. The sustained-release layer covers the needle tip. The coated microneedle can prevent a drug-containing matrix from being quickly dissolved and dispersed, prevent the active ingredient from exuding along with tissues at an action site, and increase the drug intake. The present application further discloses a method for preparing the coated microneedle and a microneedle patch including the coated microneedle.
A61M 37/00 - Autres appareils pour introduire des agents dans le corpsPercutanisation, c.-à-d. introduction de médicaments dans le corps par diffusion à travers la peau
B05D 7/00 - Procédés, autres que le flocage, spécialement adaptés pour appliquer des liquides ou d'autres matériaux fluides, à des surfaces particulières, ou pour appliquer des liquides ou d'autres matériaux fluides particuliers
7.
HEAT-RESISTANT IMPLANTABLE POLYMER MICRONEEDLE AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (Chine)
Inventeur(s)
Gao, Yunhua
Zhao, Xiaoyu
Zhang, Suohui
Abrégé
Disclosed are a heat-resistant implantable polymer microneedle and a preparation method therefor and an application thereof. The microneedle comprises a needle tip, a needle body, and a base, wherein the needle tip comprises a homogeneous system formed by mixing a biodegradable macromolecular material which has a glass transition temperature of 35-65° C. and is difficultly soluble in water and a macromolecular material having a glass transition temperature higher than that of the biodegradable macromolecular material. The microneedle has good heat resistance and puncture property.
A61M 37/00 - Autres appareils pour introduire des agents dans le corpsPercutanisation, c.-à-d. introduction de médicaments dans le corps par diffusion à travers la peau
C08L 39/06 - Homopolymères ou copolymères des N-vinylpyrrolidones
TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (Chine)
Inventeur(s)
Wang, Jingxia
Meng, Weihao
Gao, Yingtao
Jiang, Lei
Abrégé
Disclosed are a smart window foil capable of adapting to light intensity, a preparation, and a use. The smart window foil contains polymethyl methacrylate and tungsten trioxide, the tungsten trioxide comprising two states: a transparent oxidation state and a colored reduction state. After the tungsten trioxide absorbs sunlight, a transition from a colorless oxidation state to a blue reduction state is achieved, thus the smart window foil is adaptive to the intensity of sunlight to present a light color or dark color. After doping with lithium iodide, the recovery rate of the tungsten trioxide can be affected, which further affects the sensitivity of the adaptability of the smart window foil to light. The described smart window foil is transparent in both the oxidation state and blue reduction state, and can be attached to existing window glass without replacing the existing window. Moreover, said foil is easy to use, has the advantages of flexibility, self-support, low costs, no scattering, saving more energy and being environmentally friendly, etc., and has broad application prospects.
TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (Chine)
Inventeur(s)
Wu, Min
Huang, Yong
Liu, Jinfeng
Abrégé
Disclosed are an aqueous coating having water-proof and oil-proof properties, a preparation method therefor and an application thereof. The aqueous coating comprises the following components: a hydrophobic component selected from an oil-in-water Pickering emulsion; and an oil-proof component selected from one or more of natural polysaccharide substances and polyvinyl alcohol. The present invention solves the problems of the unavailability of a water-proof and oil-proof coating which is hydrophobic, waterproof, oil-proof, green, environment-friendly, safe, and applicable in a large scale.
TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (Chine)
Inventeur(s)
Wang, Shutao
Ma, Lulin
Meng, Jingxin
Zhang, Shudong
Wang, Binshuai
Bao, Han
Abrégé
A system for early diagnosis of prostate cancer, comprising: multiple medical devices used for testing a patient to obtain test data related to one or more of prostate cancer diseases; and a computer device used for analyzing patient data obtained from the multiple medical devices and analyzing the test data by using a corresponding machine learning-based analysis technique to generate a diagnosis result, the diagnosis result being used for determining whether the patient suffers from prostate cancer. According to the present invention, early diagnosis of prostate cancer is performed on a patient by means of a machine learning method in combination with an approach of detecting the number of circulating tumor cells (CTCs) and prostate-specific antibody PSA-related parameters PSA, F/T-PSA, and PSAD in the blood; in particular, early diagnosis is performed on patients whose T-PSA content is in a gray area of 4-10 ng/mL, such that the accuracy of early diagnosis and specificity are improved, non-invasive diagnosis is achieved, and overtest and overtreatment are avoided to a great extent.
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
11.
COATED MICRONEEDLE HAVING MULTI-LAYER STRUCTURE, PREPARATION METHOD THEREFOR, AND MICRONEEDLE PATCH COMPRISING COATED MICRONEEDLE
TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (Chine)
Inventeur(s)
Gao, Yunhua
Zhou, Zequan
Zhang, Suohui
Abrégé
Disclosed in the present invention are a coated microneedle having a multi-layer structure, comprising: a base, a needle tip located on the base, and a functional coating; the functional coating comprises a content containing a water-soluble polymer material and an active ingredient, and a sustained-release layer wrapping the content; and the needle tip is enveloped by the sustained-release layer. The coated microneedle can prevent rapid dissolution of a drug-containing matrix, prevent active ingredients from exuding along with tissues of a site of action, and increase a drug intake amount. Also disclosed in the present invention are a preparation method for the coated microneedle and a microneedle patch comprising the coated microneedle.
A61M 37/00 - Autres appareils pour introduire des agents dans le corpsPercutanisation, c.-à-d. introduction de médicaments dans le corps par diffusion à travers la peau
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (Chine)
Inventeur(s)
Gao, Yunhua
Zhao, Xiaoyu
Zhang, Suohui
Abrégé
A heat-resistant implantable polymer microneedle and a preparation method therefor and an application thereof. The microneedle comprises a needle tip, a needle body, and a base; the needle tip contains a homogeneous system formed by mixing a biodegradable macromolecular material which has a glass transition temperature of 35-65°C and is difficultly soluble in water and a macromolecular material having a glass transition temperature higher than the biodegradable macromolecular material. The microneedle has good heat resistance and puncture properties.
A61M 37/00 - Autres appareils pour introduire des agents dans le corpsPercutanisation, c.-à-d. introduction de médicaments dans le corps par diffusion à travers la peau
A61K 47/34 - Composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. polyesters, acides polyaminés, polysiloxanes, polyphosphazines, copolymères de polyalkylène glycol ou de poloxamères
A61K 47/22 - Composés hétérocycliques, p. ex. acide ascorbique, tocophérol ou pyrrolidones
TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (Chine)
Inventeur(s)
Yao, Jiyong
Guo, Yangwu
Li, Zhuang
Xing, Wenhao
Luo, Xiaoyu
Abrégé
4, M being selected from Ba or Sr. The nonlinear optical crystal has no symmetrical center, belongs to an orthorhombic crystal system, and has a space group Ama2. The nonlinear optical crystal is an infrared nonlinear optical crystal, and has the advantages of great nonlinear optical effect, wide light transmitting band, high hardness, good mechanical properties, breakage resistance, deliquescence resistance, easiness in processing and preserving, etc. Also disclosed in the present invention are a method for preparing the nonlinear optical crystal and application thereof.
C30B 11/02 - Croissance des monocristaux par simple solidification ou dans un gradient de température, p. ex. méthode de Bridgman-Stockbarger sans solvants
G02F 1/355 - Optique non linéaire caractérisée par les matériaux utilisés
14.
Hypocrellin derivative substituted both in a peri-position and in 2-position by amino, preparation method, and application thereof
TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (Chine)
Inventeur(s)
Wang, Pengfei
Wu, Jiasheng
Liu, Weimin
Zheng, Xiuli
Gu, Ying
Abrégé
The present invention discloses a hypocrellin derivative substituted both in a pen-position and in a 2-position by an amino, and a preparation method and use thereof. A general structural formula of the derivative is as represented by formulas I-a to I-d:
−1. Compared with unmodified hypocrellin or hypocrellin having only a 2-position modified, an absorption spectrum of the derivative is significantly red-shifted and the molar extinction coefficient is greatly improved, and the derivative can efficiently produce reactive oxygen species such as singlet oxygen in a photosensitive condition. In the same condition, the hypocrellin derivative substituted both in a pen-position and in a 2-position by an amino involved in the present invention, when used as a photosensitizer, has a stronger ability to photo-dynamically inactivate tumor cells than the first and second generation commercial photosensitizers.
A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
A61K 41/00 - Préparations médicinales obtenues par traitement de substances par énergie ondulatoire ou par rayonnement corpusculaire
C07C 221/00 - Préparation de composés contenant des groupes amino et des atomes d'oxygène, liés par des liaisons doubles, liés au même squelette carboné
C07C 225/32 - Composés contenant des groupes amino et des atomes d'oxygène, liés par des liaisons doubles, liés au même squelette carboné, au moins un des atomes d'oxygène, liés par des liaisons doubles, ne faisant pas partie d'un groupe —CHO, p. ex. aminocétones le squelette carboné contenant des atomes de carbone de cycles quinoniques ayant des groupes amino liés à des atomes de carbone de cycles quinoniques ou de systèmes cycliques condensés contenant des cycles quinoniques de systèmes cycliques quinoniques condensés formés par au moins trois cycles
C07C 227/28 - Préparation de composés contenant des groupes amino et carboxyle liés au même squelette carboné à partir de produits naturels
C07C 229/16 - Composés contenant des groupes amino et carboxyle liés au même squelette carboné ayant des groupes amino et carboxyle liés à des atomes de carbone acycliques du même squelette carboné le squelette carboné étant acyclique et saturé ayant un seul groupe amino et un seul groupe carboxyle liés au squelette carboné l'atome d'azote du groupe amino étant lié de plus à des atomes de carbone acycliques ou à des atomes de carbone de cycles autres que des cycles aromatiques à six chaînons à des atomes de carbone de radicaux hydrocarbonés substitués par des groupes amino ou carboxyle, p. ex. acide éthylènediaminetétra-acétique, acides iminodiacétiques
C07C 229/28 - Composés contenant des groupes amino et carboxyle liés au même squelette carboné ayant des groupes amino et carboxyle liés à des atomes de carbone acycliques du même squelette carboné le squelette carboné étant saturé et contenant des cycles
C07C 243/20 - Hydrazines ayant des atomes d'azote de groupes hydrazine liés à des atomes de carbone de cycles autres que des cycles aromatiques à six chaînons
C07C 323/30 - Thiols, sulfures, hydropolysulfures ou polysulfures substitués par des halogènes, des atomes d'oxygène ou d'azote ou par des atomes de soufre ne faisant pas partie de groupes thio contenant des groupes thio et des atomes d'azote, ne faisant pas partie de groupes nitro ou nitroso, liés au même squelette carboné ayant l'atome de soufre d'au moins un des groupes thio lié à un atome de carbone d'un cycle autre qu'un cycle aromatique à six chaînons du squelette carboné
C07C 323/38 - Thiols, sulfures, hydropolysulfures ou polysulfures substitués par des halogènes, des atomes d'oxygène ou d'azote ou par des atomes de soufre ne faisant pas partie de groupes thio contenant des groupes thio et des atomes d'azote, ne faisant pas partie de groupes nitro ou nitroso, liés au même squelette carboné ayant l'atome de soufre d'au moins un des groupes thio lié à un atome de carbone d'un cycle aromatique à six chaînons du squelette carboné avec l'atome de soufre du groupe thio lié à un atome de carbone d'un cycle aromatique à six chaînons faisant partie d'un système cyclique condensé
C07D 295/13 - Composés hétérocycliques contenant des cycles polyméthylène imine d'au moins cinq chaînons, des cycles aza-3 bicyclo [3.2.2] nonane, piperazine, morpholine ou thiomorpholine, ne comportant que des atomes d'hydrogène liés directement aux atomes de carbone du cycle avec des radicaux hydrocarbonés substitués liés aux atomes d'azote du cycle substitués par des atomes d'azote liés par des liaisons simples ou doubles avec les atomes d'azote du cycle et les atomes d'azote substituants liés à la même chaîne carbonée, qui n'est pas interrompue par des cycles carbocycliques à une chaîne acyclique saturée
C07D 295/205 - Radicaux dérivés de l'acide carbonique
C07D 401/12 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 403/12 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 519/00 - Composés hétérocycliques contenant plusieurs systèmes de plusieurs hétérocycles déterminants condensés entre eux ou condensés avec un système carbocyclique commun non prévus dans les groupes ou
15.
ANTIMICROBIAL POLYAMINO ACID DERIVATIVE OR COPOLYMER HAVING ALTERNATING STRUCTURE AND PREPARATION METHOD THEREFOR
TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (Chine)
Inventeur(s)
Zhang, Wei
Liu, Fuqiang
Qu, Wei
Abrégé
Disclosed are an anti-microbial polyamino acid derivative or copolymer having an alternating structure and a preparation method therefor. The polyamino acid derivative or copolymer has alternating structural units and the same conformation. One of the alternating and repeating structural units is an alkaline amino acid or a derivative thereof, and the other is another amino acid, which can be altered to obtain anti-microbial polyamino acid materials that differ in hydrophilicity or hydrophobicity, material strength, degradation rate, and antimicrobial activity. In addition, the polyamino acid derivative or copolymer prepared by the method of the present invention degrades in the body into small molecule fragments which have the same conformation and still have the alternating and repeating structural units, and which are finally degraded by the body into amino acid small molecules. Such structural features ensure the structural definiteness and controllability as well as the biocompatibility and degradability of said materials, and facilitates studies on biological activity and antimicrobial mechanism.
C08G 69/08 - Polyamides dérivés, soit des acides amino-carboxyliques, soit de polyamines et d'acides polycarboxyliques dérivés d'acides aminocarboxyliques
TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (Chine)
BAOTOU DONGBAO BIO-TECH., LTD. (Chine)
Inventeur(s)
Guo, Yanchuan
Wang, Jianing
Liu, Junli
Zhang, Bing
Wang, Furong
Liu, Fang
Abrégé
Provided are active peptides for promoting osteoblast proliferation, and a use thereof. The amino acid sequences of the active peptides are as shown in SEQ ID NO: 1 to SEQ ID NO: 5. The active peptides can promote osteoblast proliferation. These active peptides can further be developed into medicines, food products or health products.
TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (Chine)
Inventeur(s)
Guo, Yanchuan
Wang, Jianing
Zhang, Bing
Abrégé
Disclosed are an antitumor active peptide and an application thereof. The amino acid sequence of the active peptide of the present invention is shown in SEQ. ID NO.:1 - SEQ. ID NO.:5. The active peptide provided by the present invention has good antitumor activity, and in particular, can significantly inhibit the proliferation of ovarian cancer cells, and can be used for the development of antitumor drugs and health care products.
TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (Chine)
Inventeur(s)
Wang, Gexia
Ji, Junhui
Huang, Dan
Abrégé
Disclosed is a hydrolyzable copolyester. The molecular segment of the copolyester contains a segment of a difficultly hydrolyzable polyester and a segment of an easily hydrolyzable polyester, and the copolyester is a random copolymer or block copolymer composed of the segment of the difficultly hydrolyzable polyester and the segment of the easily hydrolyzable polyester. The copolyester has good strength and toughness, is biodegradable, and can degrade quickly when placed in a natural water environment. Further disclosed is a preparation method for the copolyester, and an application thereof.
C08G 63/06 - Polyesters dérivés soit d'acides hydroxycarboxyliques, soit d'acides polycarboxyliques et de composés polyhydroxylés dérivés des acides hydroxycarboxyliques
C08G 63/16 - Acides dicarboxyliques et composés dihydroxylés
C08G 63/60 - Polyesters dérivés soit d'acides hydroxycarboxyliques, soit d'acides polycarboxyliques et de composés polyhydroxylés dérivés de la réaction d'un mélange d'acides hydroxycarboxyliques, d'acides polycarboxyliques et de composés polyhydroxylés
C08G 63/85 - Germanium, étain, plomb, arsenic, antimoine, bismuth, titane, zirconium, hafnium, vanadium, niobium, tantale ou leurs composés
THE TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (Chine)
Inventeur(s)
Tang, Mingsheng
Zou, Huiming
Tian, Changqing
Abrégé
A linear compressor, comprising: a linear motor, a hollow stepped shaft piston (10) and a stepped hole cylinder (12). A bearing hole of the linear motor is provided on the stepped hole cylinder (12); one end of the hollow stepped shaft piston (10) is provided at an inner part of the linear motor and is fixedly connected to a mover (5) of the linear motor; and the hollow stepped shaft piston (10) slides linearly along the axial direction of the bearing hole, and another end of the hollow stepped shaft piston (10) penetrates the linear motor by means of the bearing hole, and is inserted into the stepped hole cylinder (12) to form a compression space inside an inner part of the stepped hole cylinder (12). In the present compressor, a resonant spring is placed at the inner part of the linear motor, and may effectively use an inner space of the motor, thus reducing the external dimensions of the linear compressor. The stepped hole cylinder and the motor bearing hole are integrally molded by using the form of the stepped hole cylinder, which may effectively prevent the phenomenon in which the stepped hole cylinder is stuck after being externally mounted with the hollow stepped shaft piston.
F04B 35/04 - Pompes à piston spécialement adaptées aux fluides compressibles et caractérisées par les moyens d'entraînement de leurs organes de travail ou par leur combinaison avec les machines motrices ou moteurs qui les entraînent ou bien par leurs adaptations à cet effet, non prévues ailleurs les moyens étant électriques
F04B 39/00 - Parties constitutives, détails ou accessoires de pompes ou de systèmes de pompage spécialement adaptés aux fluides compressibles, non prévus dans les groupes ou présentant un intérêt autre que celui visé par ces groupes
20.
WATER-SOLUBLE NATURAL POLYSACCHARIDE ANTIBACTERIAL DERIVATIVE AND PREPARATION METHOD THEREFOR
TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (Chine)
Inventeur(s)
Yao, Jiyong
Guo, Yangwu
Li, Zhuang
Xing, Wenhao
Luo, Xiaoyu
Abrégé
44, M being selected from Ba or Sr. The nonlinear optical crystal has no symmetrical center, belongs to an orthorhombic crystal system, and has space group Ama2. The nonlinear optical crystal is a nonlinear optical crystal in infrared band, and has advantages of having a great nonlinear optical effect, a wide light transmitting band, a high hardness and good mechanical properties, being less brittle and less deliquescent, being easy to process and preserve, etc. Also disclosed in the present invention are a preparation method for the nonlinear optical crystal and use thereof.
TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (Chine)
Inventeur(s)
Huang, Guiwen
Xiao, Hongmei
Liu, Yu
Qu, Chengbing
Abrégé
A low carbon environmentally friendly cut tobacco low temperature expansion process, comprising the following steps: making cut tobacco raw material absorb water to obtain wet expanded cut tobacco; dispersing the wet expanded cut tobacco in a liquid medium and freezing; extracting the frozen cut tobacco and implementing freeze-drying; and rehydrating the dried cut tobacco to the required water content to obtain expanded cut tobacco. The process is characterised by: dispersing the cut tobacco after water absorption in a liquid medium and freezing can prevent clumping of cut tobacco with a high water content, such that the frozen cut tobacco is in a puffy dispersed state, greatly increasing the subsequent drying efficiency. The preparation method conditions are mild and environmentally friendly, industrial production is easy to implement, and the expanded cut tobacco obtained by means of said method has an adjustable fill rate and good dispersibility.
TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (Chine)
Inventeur(s)
Huang, Guiwen
Xiao, Hongmei
Qu, Chengbing
Liu, Yu
Abrégé
Disclosed is an efficient preparation method for expanded shag. The preparation method comprises the following steps: a raw shag material absorbing water to obtain swollen shag; the swollen shag making contact and mixing with a water soluble liquid medium; drying the shag after contact and mixing with the liquid medium; and re-hydrating the dried shag to achieve a required water content and obtaining the expanded shag. The features of the method of the present invention comprise the following: A mixed solution is formed by contact between a liquid medium and water in the shag, and changing the permeability of the shag by the mixed solution can eliminate or reduce drying shrinkage stress caused by water during the drying process thereof, so as to maintain the expansion volume of the shag. The process is fast and effective with mild reaction conditions. An expansion rate of the expanded shag prepared by the method is adjustable. The efficient method achieves continuous production of expanded shag.
TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (Chine)
Inventeur(s)
Zhou, Shuyun
Zou, Yingquan
Liu, Jinying
Xing, Fang
Xiao, Shizhuo
Chen, Ping
Zhao, Jian
Abrégé
Disclosed is a heat-sensitive processless planographic printing plate material containing a thermosensitive protection layer. The planographic printing plate material sequentially comprises a supporting body, a hydrophilic layer, a heat-sensitive layer and a thermosensitive protection layer from the bottom up. The thermosensitive protection layer therein can not only isolate oxygen and protect the heat-sensitive layer from oxygen inhibition, but can also sense heat and allow a polymerization reaction to take place. Thus the binding force between same and the next layer is improved, so that the precision of printing plate images is high, the development performance is good, and the pressrun is high.
TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (Chine)
Inventeur(s)
Niu, Zhongwei
Zhu, Meng
Jiang, Shidong
Abrégé
Disclosed in the present invention are a water-soluble chitosan antimicrobial derivative and a preparation method therefor. The water-soluble chitosan antimicrobial derivative comprises chitosan frameworks and dual-function groups for modifying amino groups on the chitosan frameworks, and the dual-function groups are guanidine groups and carbonyl methoxy polyethylene glycol. In the present invention, guanidine groups and short-chain polyethylene glycol are modified on side chains of the chitosan at the same time, and a good antimicrobial function and higher biological safety are brought to the chitosan. In the preparation method in the present invention, chitosan reacts with carbonyl methoxy polyethylene glycol first, so that the water solubility of the chitosan is fully improved, and the biological safety is greatly improved; then, a reaction with thiourea trioxide is carried out, so that graft guanidine groups in the first step are avoided, and amino groups participate in subsequence reactions, it is effectively ensured that guanidine groups have rich positive charges and the positive charge density in the water-soluble chitosan antimicrobial derivative is ensured, and accordingly, antimicrobial performance of the water-soluble chitosan antimicrobial derivative is better.
TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (Chine)
Inventeur(s)
Wang, Pengfei
Wu, Jiasheng
Liu, Weimin
Zheng, Xiuli
Gu, Ying
Abrégé
The present invention discloses a hypocrellin derivative substituted both in a peri-position and in a 2-position by an amino, and a preparation method and use thereof. A general structural formula of the derivative is as represented by formulas I-a to I-d: (see formula I-a)(see formula I-b)(see formula I-c)(see formula I-d) The hypocrellin derivative substituted both in a peri-position and in a 2- position by an amino prepared in the present invention has a maximum absorption wavelength of 600-650 nm and a molar extinction coefficient reaching about 20000-40000 M -1cm -1. Compared with unmodified hypocrellin or hypocrellin having only a 2-position modified, an absorption spectrum of the derivative is significantly red-shifted and the molar extinction coefficient is greatly improved, and the derivative can efficiently produce reactive oxygen species such as singlet oxygen in a photosensitive condition. In the same condition, the hypocrellin derivative substituted both in a peri-position and in a 2-position by an amino involved in the present invention, when used as a photosensitizer, has a stronger ability to photo- dynamically inactivate tumor cells than the first and second generation commercial photosensitizers.
C07C 221/00 - Préparation de composés contenant des groupes amino et des atomes d'oxygène, liés par des liaisons doubles, liés au même squelette carboné
A61K 41/00 - Préparations médicinales obtenues par traitement de substances par énergie ondulatoire ou par rayonnement corpusculaire
C07C 225/32 - Composés contenant des groupes amino et des atomes d'oxygène, liés par des liaisons doubles, liés au même squelette carboné, au moins un des atomes d'oxygène, liés par des liaisons doubles, ne faisant pas partie d'un groupe —CHO, p. ex. aminocétones le squelette carboné contenant des atomes de carbone de cycles quinoniques ayant des groupes amino liés à des atomes de carbone de cycles quinoniques ou de systèmes cycliques condensés contenant des cycles quinoniques de systèmes cycliques quinoniques condensés formés par au moins trois cycles
C07C 249/02 - Préparation de composés contenant des atomes d'azote, liés par des liaisons doubles à un squelette carboné de composés contenant des groupes imino
C07C 251/24 - Composés contenant des atomes d'azote, liés par des liaisons doubles à un squelette carboné contenant des groupes imino ayant des atomes de carbone de groupes imino liés à des atomes de carbone de cycles aromatiques à six chaînons
27.
DERIVATIVES OF HYPOCRELLIN WITH PERI-POSITION AND 2-POSITION SIMULTANEOUSLY SUBSTITUTED BY AMINO GROUPS
TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (Chine)
Inventeur(s)
Wang, Pengfei
Wu, Jiasheng
Liu, Weimin
Zheng, Xiuli
Gu, Ying
Abrégé
Derivatives of hypocrellin with peri-position and 2-position simultaneously substituted by amino groups and a preparation method and application thereof are disclosed. The structural formula of the derivatives is as shown in the formulae I-a to I-d. The prepared derivatives of hypocrellin with peri-position and 2-position simultaneously substituted by amino groups have a maximum absorption wavelength of 600-650nm, and a molar extinction coefficient of about 20000-40000M -1cm -1. Compared with unmodified hypocrellin or hypocrellin only modified at 2-position, the prepared derivatives of hypocrellin have a significantly red-shifted absorption spectrum and a greatly enhanced molar extinction coefficient, and can efficiently produce reactive oxygen species such as singlet oxygen under a photosensitive condition. Under the same condition, the derivatives of hypocrellin with peri-position and 2-position simultaneously substituted by amino groups act as photosensitizers, and have higher photodynamic inactivation of tumor cells than the first and second generations of commercial photosensitizers.
C07C 221/00 - Préparation de composés contenant des groupes amino et des atomes d'oxygène, liés par des liaisons doubles, liés au même squelette carboné
C07C 225/32 - Composés contenant des groupes amino et des atomes d'oxygène, liés par des liaisons doubles, liés au même squelette carboné, au moins un des atomes d'oxygène, liés par des liaisons doubles, ne faisant pas partie d'un groupe —CHO, p. ex. aminocétones le squelette carboné contenant des atomes de carbone de cycles quinoniques ayant des groupes amino liés à des atomes de carbone de cycles quinoniques ou de systèmes cycliques condensés contenant des cycles quinoniques de systèmes cycliques quinoniques condensés formés par au moins trois cycles
C07C 249/02 - Préparation de composés contenant des atomes d'azote, liés par des liaisons doubles à un squelette carboné de composés contenant des groupes imino
C07C 251/24 - Composés contenant des atomes d'azote, liés par des liaisons doubles à un squelette carboné contenant des groupes imino ayant des atomes de carbone de groupes imino liés à des atomes de carbone de cycles aromatiques à six chaînons
A61K 41/00 - Préparations médicinales obtenues par traitement de substances par énergie ondulatoire ou par rayonnement corpusculaire
TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (Chine)
Inventeur(s)
Niu, Zhongwei
Jiang, Shidong
Abrégé
Disclosed is a new type water-soluble natural polysaccharide antibacterial material. The molecules of the new type water-soluble natural polysaccharide antibacterial material not only contain guanidyl, but also contain amino acid groups, so that the biosafety of the same is taken into consideration while the antibacterial property of chitosan is improved, and the new type water-soluble natural polysaccharide antibacterial material has a low cytotoxicity and is a green antibacterial product. Also disclosed is a method for preparing the above-mentioned material, comprising the steps of: 1) dissolving chitosan in a diluted acid solution to obtain a diluted acid aqueous solution of chitosan; 2) adding cyanamide or dicyandiamide into the diluted acid aqueous solution of chitosan obtained in step 1) for reaction; 3) adding an amino acid activation solution into the reaction system in the step 2) for amidation; 4) adding hydroxylamine hydrochloride to terminate the reaction; and 5) filtering the reaction solution and then dialyzing same with deionized water, and microwave vacuum-drying to obtain the new type water-soluble natural polysaccharide antibacterial material. The new type water-soluble natural polysaccharide antibacterial material can be prepared in a reaction kettle by a primary reaction by means of the method, and the used primary raw materials are rich in sources and low in price and are suitable for industrial production.
C08B 37/08 - ChitineSulfate de chondroïtineAcide hyaluroniqueLeurs dérivés
A01N 43/16 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés hétérocycliques comportant des cycles avec un ou plusieurs atomes d'oxygène ou de soufre comme uniques hétéro-atomes du cycle avec un hétéro-atome des cycles à six chaînons avec l'oxygène comme hétéro-atome du cycle
A01P 1/00 - DésinfectantsComposés antimicrobiens ou leurs mélanges
29.
INORGANIC SALT-CONTAINING LAYERED DISSOLVING MICRO-NEEDLE CONTAINING INORGANIC SALT
TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (Chine)
Inventeur(s)
Gao, Yunhua
Yang, Guozhong
He, Meilin
Zhao, Xiaoyu
Zhang, Suohui
Abrégé
An inorganic salt-containing layered dissolving micro-needle containing inorganic salt, and a preparation method therefor. The inorganic salt-containing layered dissolving micro-needle comprises a substrate, a needle body on the substrate, and a needle tip on the needle body. The needle tip is made by mixing an inorganic salt solution, a stabilizer, a film-forming water-soluble polymer material, and a bioactive component; the needle body and the substrate are made of the film-forming water-soluble polymer material, or the film-forming water-soluble polymer material and the stabilizer. The inorganic salt-containing layered dissolving micro-needle containing inorganic salt improves the formability of a needle tip of an inorganic salt-containing micro-needle and improves stability of a bioactive component.
TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (Chine)
Inventeur(s)
Wang, Pengfei
Wu, Jiasheng
Liu, Weimin
Gu, Ying
Ge, Jiechao
Zheng, Xiuli
Zhang, Hongyan
Abrégé
The invention discloses a monosubstituted or polysubstituted amphiphilic hypocrellin derivative, and a preparation method and application thereof. The amphiphilic hypocrellin derivative substituted by a group containing PEG, a quaternary ammonium salt or the like prepared according to the invention has an obvious red shift in its absorption spectrum and a significantly enhanced molar extinction coefficient, compared with the parent hypocrellin, can efficiently produce singlet state oxygen and other reactive oxygen species under photosensitive conditions; has different amphiphilicities and increased biocompatibility with cells or tissues by regulating its hydrophilicity and hydrophobicity; can meet the requirements of different clinical drugs, and solves the requirements of different drug delivery methods for different drug hydrophilicity and lipophilicity. Under identical conditions, the amphiphilic hypocrellin derivative photosensitizer according to the invention has higher ability to photodynamically inactivate tumor cells than the first and second generation commercial photosensitizers.
C07C 217/12 - Composés contenant des groupes amino et hydroxy éthérifiés liés au même squelette carboné ayant des groupes hydroxy éthérifiés et des groupes amino liés à des atomes de carbone acycliques du même squelette carboné le squelette carboné étant acyclique et saturé ayant un seul groupe hydroxy éthérifié et un seul groupe amino liés au squelette carboné, qui n'est pas substitué par ailleurs l'atome d'oxygène du groupe hydroxy éthérifié étant lié de plus à un atome de carbone d'un cycle autre qu'un cycle aromatique à six chaînons
C07C 221/00 - Préparation de composés contenant des groupes amino et des atomes d'oxygène, liés par des liaisons doubles, liés au même squelette carboné
C07C 225/22 - Composés contenant des groupes amino et des atomes d'oxygène, liés par des liaisons doubles, liés au même squelette carboné, au moins un des atomes d'oxygène, liés par des liaisons doubles, ne faisant pas partie d'un groupe —CHO, p. ex. aminocétones ayant des groupes amino liés à des atomes de carbone de cycles aromatiques à six chaînons du squelette carboné
C07C 225/32 - Composés contenant des groupes amino et des atomes d'oxygène, liés par des liaisons doubles, liés au même squelette carboné, au moins un des atomes d'oxygène, liés par des liaisons doubles, ne faisant pas partie d'un groupe —CHO, p. ex. aminocétones le squelette carboné contenant des atomes de carbone de cycles quinoniques ayant des groupes amino liés à des atomes de carbone de cycles quinoniques ou de systèmes cycliques condensés contenant des cycles quinoniques de systèmes cycliques quinoniques condensés formés par au moins trois cycles
C07C 229/18 - Composés contenant des groupes amino et carboxyle liés au même squelette carboné ayant des groupes amino et carboxyle liés à des atomes de carbone acycliques du même squelette carboné le squelette carboné étant acyclique et saturé ayant un seul groupe amino et un seul groupe carboxyle liés au squelette carboné l'atome d'azote du groupe amino étant lié de plus à des atomes de carbone de cycles aromatiques à six chaînons
C07C 237/08 - Amides d'acides carboxyliques, le squelette carboné de la partie acide étant substitué de plus par des groupes amino ayant les atomes de carbone des groupes carboxamide liés à des atomes de carbone acycliques du squelette carboné le squelette carboné étant acyclique et saturé ayant l'atome d'azote d'au moins un des groupes carboxamide lié à un atome de carbone acyclique d'un radical hydrocarboné substitué par des atomes d'oxygène liés par des liaisons simples
C07C 239/14 - Composés hydroxylaminés ou leurs éthers ou esters ayant des atomes d'azote de groupes hydroxylamino liés de plus à des atomes de carbone de radicaux hydrocarbonés substitués par des atomes d'oxygène liés par des liaisons doubles
C07C 243/22 - Hydrazines ayant des atomes d'azote de groupes hydrazine liés à des atomes de carbone de cycles aromatiques à six chaînons
C07C 249/02 - Préparation de composés contenant des atomes d'azote, liés par des liaisons doubles à un squelette carboné de composés contenant des groupes imino
C07C 251/24 - Composés contenant des atomes d'azote, liés par des liaisons doubles à un squelette carboné contenant des groupes imino ayant des atomes de carbone de groupes imino liés à des atomes de carbone de cycles aromatiques à six chaînons
C07C 251/56 - Oximes ayant des atomes d'oxygène de groupes oxyimino liés à des atomes de carbone de radicaux hydrocarbonés substitués de radicaux hydrocarbonés substitués par des atomes d'oxygène liés par des liaisons doubles
C07C 251/86 - Hydrazones ayant des atomes de carbone, liés par des liaisons doubles, de groupes hydrazone liés à des atomes de carbone de cycles aromatiques à six chaînons
C07C 309/69 - Esters d'acides sulfoniques ayant des atomes de soufre de groupes sulfo estérifiés liés à des atomes de carbone acycliques d'un squelette carboné substitué par des atomes d'azote ne faisant pas partie de groupes nitro ou nitroso
A61K 31/122 - Cétones ayant l'atome d'oxygène lié directement à un cycle, p. ex. quinones, vitamine K1, anthraline
A61K 31/135 - Amines, p. ex. amantadine ayant des cycles aromatiques, p. ex. méthadone
A61K 31/473 - QuinoléinesIsoquinoléines condensées en ortho ou en péri avec des systèmes carbocycliques, p. ex. acridines, phénantridines
A61K 41/00 - Préparations médicinales obtenues par traitement de substances par énergie ondulatoire ou par rayonnement corpusculaire
A61K 47/54 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique
A61K 47/60 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique macromoléculaire, p. ex. une molécule oligomérique, polymérique ou dendrimérique obtenu par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. polyurées ou polyuréthanes le composé organique macromoléculaire étant un oligomère, un polymère ou un dendrimère de polyoxyalkylène, p. ex. PEG, PPG, PEO ou polyglycérol
C07C 323/25 - Thiols, sulfures, hydropolysulfures ou polysulfures substitués par des halogènes, des atomes d'oxygène ou d'azote ou par des atomes de soufre ne faisant pas partie de groupes thio contenant des groupes thio et des atomes d'azote, ne faisant pas partie de groupes nitro ou nitroso, liés au même squelette carboné ayant les atomes de soufre des groupes thio liés à des atomes de carbone acycliques du squelette carboné le squelette carboné étant acyclique et saturé
C07C 319/18 - Préparation de thiols, de sulfures, d'hydropolysulfures ou de polysulfures de sulfures par addition de thiols à des composés non saturés
C07D 279/14 - Thiazines-1, 4Thiazines-1, 4 hydrogénées condensés avec des carbocycles ou avec des systèmes carbocycliques
C07D 241/38 - Composés hétérocycliques contenant des cycles diazine-1,4 ou diazine-1,4 hydrogéné condensés avec des carbocycles ou avec des systèmes carbocycliques avec uniquement des atomes d'hydrogène ou de carbone liés directement aux atomes d'azote du cycle
C07C 50/36 - Quinones contenant des groupes dont les atomes d'oxygène sont liés par liaison simple à des atomes de carbone la structure quinoïde faisant partie d'un système cyclique condensé d'au moins quatre cycles
C07D 221/02 - Composés hétérocycliques contenant des cycles à six chaînons ne comportant qu'un atome d'azote comme unique hétéro-atome du cycle, non prévus par les groupes condensés avec des carbocycles ou avec des systèmes carbocycliques
31.
METHOD FOR MAINTAINING MESENCHYMAL STEM CELL PLURIPOTENCY IN VITRO
TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (Chine)
Inventeur(s)
Niu, Zhongwei
Ren, Xiaoxue
Jiang, Shidong
Shi, Haigang
Abrégé
Provided is a method for maintaining mesenchymal stem cell pluripotency in vitro, comprising the following steps: (1) extraction, primary culturing and subculturing of mesenchymal stem cells; (2) by means of a method combining friction orientation and epitaxial crystallization, preparing a composite membrane culture medium the surface of which has an orientation microstructure; (3) culturing mesenchymal stem cells on the composite membrane culture medium prepared in step (2).
Technical Institute of Physics and Chemistry of the Chinese Academy of Sciences (Chine)
Inventeur(s)
Duan, Xuanming
Dong, Xianzi
Zheng, Meiling
Abrégé
A maskless photolithoghrapic system includes a laser point-by-point scanning exposure unit, a plane-projection exposure unit, a mobile station and a calculation control unit that decomposes a pattern to be exposed, so that a pattern portion with a precision requirement below a pre-determined threshold is exposed by the laser point-by-point scanning exposure unit, and a pattern portion with a precision requirement greater than the pre-determined threshold is exposed by the plane-projection exposure unit; when conducting laser point-by-point scanning exposure on a sample on the mobile station, the light emitted by the laser point-by-point scanning exposure unit moves relative to the sample according to the pattern portion with a precision requirement below the pre-determined threshold; and when conducting plane-projection exposure on the sample, the plane-projection exposure unit emits light with a corresponding pattern shape onto the sample according to the graph with a precision requirement greater than the pre-determined threshold.
TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (Chine)
Inventeur(s)
Wang, Pengfei
Ge, Jiechao
Wu, Jiasheng
Zheng, Xiuli
Gu, Ying
Liu, Weimin
Zhang, Hongyan
Abrégé
A nanoassembly of a hypocrellin derivative, prepared by using a hypocrellin derivative and an amphiphile as precursors, and utilizing the self-assembly property between the amphiphile and the hypocrellin molecule to obtain the nanoassembly with a size of 20-200 nm and a maximum absorption wavelength range of 650-850 nm. The obtained nanoassembly can be used as a photosensitizer agent in photodynamic therapy for treating a tumor.
A61K 9/127 - Vecteurs à bicouches synthétiques, p. ex. liposomes ou liposomes comportant du cholestérol en tant qu’unique agent tensioactif non phosphatidylique
A61K 47/34 - Composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. polyesters, acides polyaminés, polysiloxanes, polyphosphazines, copolymères de polyalkylène glycol ou de poloxamères
A61K 47/32 - Composés macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. carbomères
TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (Chine)
Inventeur(s)
Zhou, Shuyun
Zou, Yingquan
Liu, Jinying
Xing, Fang
Xiao, Shizhuo
Chen, Ping
Zhao, Jian
Abrégé
Disclosed is a heat-sensitive processless planographic printing plate material containing a thermosensitive protection layer. The planographic printing plate material sequentially comprises a supporting body, a hydrophilic layer, a heat-sensitive layer and a thermosensitive protection layer from the bottom up. The thermosensitive protection layer therein can not only isolate oxygen and protect the heat-sensitive layer from oxygen inhibition, but can also sense heat and allow a polymerization reaction to take place. Thus the binding force between same and the next layer is improved, so that the precision of printing plate images is high, the development performance is good, and the pressrun is high.
TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (Chine)
Inventeur(s)
Lv, Zhendong
Niu, Zhongwei
Jiang, Shidong
Abrégé
Provided are a chitosan derivative-based disinfectant and a preparation method therefor. The disinfectant comprises 0.05 to 10 g of chitosan derivative and 100 ml of sterilized deionized water. The disinfectant can be used as a bactericidal disinfectant in medical treatment and can be used for disinfection of skin or mucous membranes and the like.
A01N 43/16 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés hétérocycliques comportant des cycles avec un ou plusieurs atomes d'oxygène ou de soufre comme uniques hétéro-atomes du cycle avec un hétéro-atome des cycles à six chaînons avec l'oxygène comme hétéro-atome du cycle
A01P 1/00 - DésinfectantsComposés antimicrobiens ou leurs mélanges
TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (Chine)
Inventeur(s)
Wu, Min
Huang, Yong
Zhao, Mengmeng
Abrégé
Disclosed is a preparation method for a hydrophobic inorganic powder material. The preparation method comprises the following steps: mixing and grinding an inorganic powder material and a hydrophobic material; and after grinding, uniformly coating the surface of the inorganic powder material with the hydrophobic material, and separating and removing the redundant hydrophobic material to obtain the hydrophobic inorganic powder material. The preparation method is simple, low in cost, and green and environmentally protective. Also disclosed is the hydrophobic inorganic powder material prepared and obtained by using this method, wherein the particle size of the material is 0.01-500 μm, the hydrophobic performance is excellent, and the contact angle with water can reach 150º.
C09C 3/04 - Traitement physique, p. ex. broyage, traitement par des vibrations ultrasoniques
C09C 3/00 - Traitement, en général, de substances inorganiques, autres que des charges fibreuses, pour améliorer leurs propriétés de pigmentation ou de charge
C09C 1/02 - Composés du magnésium ou des métaux alcalino-terreux
TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (Chine)
Inventeur(s)
Geng, Jianxin
Xu, Linli
Huang, Yong
Abrégé
Disclosed in the present invention are a highly effective non-halogen composite flame retardant and a preparation method therefor. The composite flame retardant is made up of the following raw material components by weight: 100 parts graphite-type material; 50-600 parts phosphorus-type flame retardant. Also disclosed is a preparation method for said composite flame retardant. The process of the technical solution of the present invention is simple, and the production period is short; graphite-type material is converted into a graphene-type material, realizing a composite of graphite-type material and phosphorus-type flame retardant; the composite flame retardant obtained is characterized by a high specific surface area, not agglomerating easily, being easily dispersed in ionic and non-ionic solvents, high flame retardant effectiveness, and good smoke suppression; the composite can be used as a flame retardant and enhancer in multiple types of saturated resin, unsaturated resin, hot melt adhesive, rubber and coating, and can also improve wear resistance of rubber and corrosion resistance of coatings.
TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (Chine)
Inventeur(s)
Xu, Zuyan
Bi, Yong
Liu, Ke
Peng, Qinjun
Gao, Weinan
Zong, Nan
Abrégé
A laser display system includes a red light semiconductor laser module (1), a green light semiconductor laser module (2), a blue light semiconductor laser module (3), a decoherence device (7, 8, 9), light valves (12, 13, 14), collimating and shaping devices (4, 5, 6), a heat dissipating modules (16-1, 16-2, 16-3), a temperature control module (17) and a semiconductor laser control module (18). The wavelength range output by the red light semiconductor laser module (1) is from 635 nm to 670 nm; the wavelength range output by the green light semiconductor laser module (2) is from 515 nm to 530 nm; the wavelength range output by the blue light semiconductor laser module (3) is from 440 nm to 460 nm.
G02B 27/20 - Systèmes ou appareils optiques non prévus dans aucun des groupes , pour projection optique, p. ex. combinaison de miroir, de condensateur et d'objectif pour donner une image d'objets minuscules, p. ex. indicateur lumineux
H04N 9/31 - Dispositifs de projection pour la présentation d'images en couleurs
G02B 27/10 - Systèmes divisant ou combinant des faisceaux
G02B 27/09 - Mise en forme du faisceau, p. ex. changement de la section transversale, non prévue ailleurs
G09G 3/34 - Dispositions ou circuits de commande présentant un intérêt uniquement pour l'affichage utilisant des moyens de visualisation autres que les tubes à rayons cathodiques pour la présentation d'un ensemble de plusieurs caractères, p. ex. d'une page, en composant l'ensemble par combinaison d'éléments individuels disposés en matrice en commandant la lumière provenant d'une source indépendante
G03B 21/00 - Projecteurs ou visionneuses du type par projectionLeurs accessoires
G03B 33/12 - Enregistrement ou projection simultanés faisant usage de systèmes à division des rayons ou à combinaison des rayons, p. ex. de miroirs dichroïques
39.
MONOSUBSTITUTED OR POLYSUBSTITUTED AMPHIPHILIC HYPOCRELLIN DERIVATIVE, PREPARATION METHOD THEREFOR, AND USES THEREOF
TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (Chine)
Inventeur(s)
Wang, Pengfei
Wu, Jiasheng
Liu, Weimin
Gu, Ying
Ge, Jiechao
Zheng, Xiuli
Zhang, Hongyan
Abrégé
The invention discloses a monosubstituted or polysubstituted amphiphilic hypocrellin derivative, and a preparation method and application thereof. The amphiphilic hypocrellin derivative substituted by a group containing PEG, a quaternary ammonium salt or the like prepared according to the invention has an obvious red shift in its absorption spectrum and a significantly enhanced molar extinction coefficient, compared with the parent hypocrellin, can efficiently produce singlet state oxygen and other reactive oxygen species under photosensitive conditions; has different amphiphilicities and increased biocompatibility with cells or tissues by regulating its hydrophilicity and hydrophobicity; can meet the requirements of different clinical drugs, and solves the requirements of different drug delivery methods for different drug hydrophilicity and lipophilicity. Under identical conditions, the amphiphilic hypocrellin derivative photosensitizer according to the invention has higher ability to photodynamically inactivate tumor cells than the first and second generation commercial photosensitizers.
C07C 309/69 - Esters d'acides sulfoniques ayant des atomes de soufre de groupes sulfo estérifiés liés à des atomes de carbone acycliques d'un squelette carboné substitué par des atomes d'azote ne faisant pas partie de groupes nitro ou nitroso
C07C 225/32 - Composés contenant des groupes amino et des atomes d'oxygène, liés par des liaisons doubles, liés au même squelette carboné, au moins un des atomes d'oxygène, liés par des liaisons doubles, ne faisant pas partie d'un groupe —CHO, p. ex. aminocétones le squelette carboné contenant des atomes de carbone de cycles quinoniques ayant des groupes amino liés à des atomes de carbone de cycles quinoniques ou de systèmes cycliques condensés contenant des cycles quinoniques de systèmes cycliques quinoniques condensés formés par au moins trois cycles
C07C 229/14 - Composés contenant des groupes amino et carboxyle liés au même squelette carboné ayant des groupes amino et carboxyle liés à des atomes de carbone acycliques du même squelette carboné le squelette carboné étant acyclique et saturé ayant un seul groupe amino et un seul groupe carboxyle liés au squelette carboné l'atome d'azote du groupe amino étant lié de plus à des atomes de carbone acycliques ou à des atomes de carbone de cycles autres que des cycles aromatiques à six chaînons à des atomes de carbone de squelettes carbonés contenant des cycles
C07C 237/08 - Amides d'acides carboxyliques, le squelette carboné de la partie acide étant substitué de plus par des groupes amino ayant les atomes de carbone des groupes carboxamide liés à des atomes de carbone acycliques du squelette carboné le squelette carboné étant acyclique et saturé ayant l'atome d'azote d'au moins un des groupes carboxamide lié à un atome de carbone acyclique d'un radical hydrocarboné substitué par des atomes d'oxygène liés par des liaisons simples
C07C 249/02 - Préparation de composés contenant des atomes d'azote, liés par des liaisons doubles à un squelette carboné de composés contenant des groupes imino
C07C 251/24 - Composés contenant des atomes d'azote, liés par des liaisons doubles à un squelette carboné contenant des groupes imino ayant des atomes de carbone de groupes imino liés à des atomes de carbone de cycles aromatiques à six chaînons
C07C 319/18 - Préparation de thiols, de sulfures, d'hydropolysulfures ou de polysulfures de sulfures par addition de thiols à des composés non saturés
C07C 323/45 - Thiols, sulfures, hydropolysulfures ou polysulfures substitués par des halogènes, des atomes d'oxygène ou d'azote ou par des atomes de soufre ne faisant pas partie de groupes thio contenant des groupes thio et des atomes d'azote, ne faisant pas partie de groupes nitro ou nitroso, liés au même squelette carboné ayant au moins un des atomes d'azote lié par une liaison double au squelette carboné
40.
MONOSUBSTITUTED OR POLYSUBSTITUTED AMPHIPHILIC HYPOCRELLIN DERIVATIVE, PREPARATION METHOD THEREFOR, AND USES THEREOF
TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (Chine)
Inventeur(s)
Wang, Pengfei
Wu, Jiasheng
Liu, Weimin
Gu, Ying
Ge, Jiechao
Zheng, Xiuli
Zhang, Hongyan
Abrégé
Disclosed are a monosubstituted or polysubstituted amphiphilic hypocrellin derivative, preparation method therefor, and uses thereof. In the present invention, the amphiphilic hypocrellin derivative having substituted functional groups such as condensed ethylene glycol and quaternary ammonium salt shows in its absorption spectrum a substantial redshift and an enhanced molar extinction coefficient compared to hypocrellin precursor, and can highly effectively produce reactive oxygen species such as singlet state oxygen under light-sensitive conditions. By adjusting the hydrophobicity and hydrophilicity of said derivative, said derivative can have different amphiphilicity and enhanced biocompatibility with cells or tissues. The amphiphilic hypocrellin derivative can satisfy the requirements for different clinical medications and addresses the conflict between medicinal hydrophilicity and lipophilicity caused by different administration methods. Compared to the first and second generation commercial photosensitizer, under the same conditions, the amphiphilic hypocrellin derivative photosensitizer of the present invention has higher photodynamic capabilities in the eradication of live tumor cells.
C07C 221/00 - Préparation de composés contenant des groupes amino et des atomes d'oxygène, liés par des liaisons doubles, liés au même squelette carboné
C07C 225/32 - Composés contenant des groupes amino et des atomes d'oxygène, liés par des liaisons doubles, liés au même squelette carboné, au moins un des atomes d'oxygène, liés par des liaisons doubles, ne faisant pas partie d'un groupe —CHO, p. ex. aminocétones le squelette carboné contenant des atomes de carbone de cycles quinoniques ayant des groupes amino liés à des atomes de carbone de cycles quinoniques ou de systèmes cycliques condensés contenant des cycles quinoniques de systèmes cycliques quinoniques condensés formés par au moins trois cycles
C07C 249/02 - Préparation de composés contenant des atomes d'azote, liés par des liaisons doubles à un squelette carboné de composés contenant des groupes imino
C07C 251/24 - Composés contenant des atomes d'azote, liés par des liaisons doubles à un squelette carboné contenant des groupes imino ayant des atomes de carbone de groupes imino liés à des atomes de carbone de cycles aromatiques à six chaînons
C07C 319/18 - Préparation de thiols, de sulfures, d'hydropolysulfures ou de polysulfures de sulfures par addition de thiols à des composés non saturés
C07C 323/25 - Thiols, sulfures, hydropolysulfures ou polysulfures substitués par des halogènes, des atomes d'oxygène ou d'azote ou par des atomes de soufre ne faisant pas partie de groupes thio contenant des groupes thio et des atomes d'azote, ne faisant pas partie de groupes nitro ou nitroso, liés au même squelette carboné ayant les atomes de soufre des groupes thio liés à des atomes de carbone acycliques du squelette carboné le squelette carboné étant acyclique et saturé
C07C 213/06 - Préparation de composés contenant des groupes amino et hydroxy, amino et hydroxy éthérifiés ou amino et hydroxy estérifiés liés au même squelette carboné à partir d'hydroxyamines par des réactions impliquant l'éthérification ou l'estérification de groupes hydroxy
C07C 217/12 - Composés contenant des groupes amino et hydroxy éthérifiés liés au même squelette carboné ayant des groupes hydroxy éthérifiés et des groupes amino liés à des atomes de carbone acycliques du même squelette carboné le squelette carboné étant acyclique et saturé ayant un seul groupe hydroxy éthérifié et un seul groupe amino liés au squelette carboné, qui n'est pas substitué par ailleurs l'atome d'oxygène du groupe hydroxy éthérifié étant lié de plus à un atome de carbone d'un cycle autre qu'un cycle aromatique à six chaînons
A61K 41/00 - Préparations médicinales obtenues par traitement de substances par énergie ondulatoire ou par rayonnement corpusculaire
TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (Chine)
Inventeur(s)
Duan, Xuanming
Dong, Xianzi
Zheng, Meiling
Abrégé
A maskless photolithoghrapic system in a cooperative working mode for a cross-scale structure, comprising: a laser point-by-point scanning exposure unit, a plane-projection exposure unit, a mobile station (19) and a calculation control unit (20), wherein the calculation control unit (20) decomposes a graph to be exposed, so that a graph with a precision requirement below a pre-determined threshold is exposed by the laser point-by-point scanning exposure unit, and a graph with a precision requirement greater than the pre-determined threshold is exposed by the plane-projection exposure unit; when conducting laser point-by-point scanning exposure on a sample on the mobile station (19), the light emitted by the laser point-by-point scanning exposure unit moves relative to the sample according to the graph with a precision requirement below the pre-determined threshold, thereby realizing the laser point-by-point scanning exposure of the sample; and when conducting plane-projection exposure on the sample, the plane-projection exposure unit emits light with a corresponding graph shape onto the sample according to the graph with a precision requirement greater than the pre-determined threshold, thereby realizing the plane-projection exposure of the sample.
Technical Institute of Physics and Chemistry of the Chinese Academy of Sciences (Chine)
Inventeur(s)
Duan, Xuanming
Chen, Shu
Cao, Hongzhong
Dong, Xianzi
Zhao, Zhensheng
Abrégé
A laser micro/nano processing system (100, 200, 300, 400) comprises: a laser light source used to provide a first laser beam having a first wavelength and a second laser beam having a second wavelength different from the first wavelength, with the pulse width of the first laser beam being in the range from a nanosecond to a femtosecond; an optical focusing assembly used to focus the first laser beam and the second laser beam to the same focal point; and a micro mobile platform (21) controlled by a computer. Also disclosed are a method for micro/nano-processing photosensitive materials with a laser and a method for fabricating a device with a micro/nano structure using laser two-photon direct writing technology. In the system and methods, spatial and temporal overlapping of two laser beams is utilized, so as to obtain a micro/nano structure with a processing resolution higher than that of a single laser beam, using an average power lower than that of a single laser beam.
H01L 21/00 - Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de dispositifs à semi-conducteurs ou de dispositifs à l'état solide, ou bien de leurs parties constitutives
B23K 26/0622 - Mise en forme du faisceau laser, p. ex. à l’aide de masques ou de foyers multiples par commande directe du faisceau laser par impulsions de mise en forme
B23K 26/064 - Mise en forme du faisceau laser, p. ex. à l’aide de masques ou de foyers multiples au moyen d'éléments optiques, p. ex. lentilles, miroirs ou prismes
B23K 26/06 - Mise en forme du faisceau laser, p. ex. à l’aide de masques ou de foyers multiples
B23K 26/067 - Division du faisceau en faisceaux multiples, p. ex. foyers multiples
B81C 1/00 - Fabrication ou traitement de dispositifs ou de systèmes dans ou sur un substrat
H01L 21/02 - Fabrication ou traitement des dispositifs à semi-conducteurs ou de leurs parties constitutives
TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (Chine)
Inventeur(s)
Xu, Zuyan
Bi, Yong
Liu, Ke
Peng, Qinjun
Gao, Weinan
Zong, Nan
Abrégé
A laser display system. The laser display system comprises a red-light semiconductor laser module (1), a green-light semiconductor laser module (2), a blue-light semiconductor laser module (3), coherence eliminators (7, 8, 9), light valves (12, 13, 14), collimation shaping devices (4, 5, 6), heat dissipation modules (16-1, 16-2, 16-3), a temperature control module (17) and a semiconductor laser control module (18). The red-light semiconductor laser module (1) has an output wavelength range of 635 nm to 670 nm; the green-light semiconductor laser module (2) has an output wavelength range of 515 nm to 530 nm; and the blue-light semiconductor laser module (3) has an output wavelength range of 440 nm to 460 nm. The chroma triangular area can be as large as possible through adjustable wavelengths, and the display colors are richer and brighter. The laser display system has the common advantages of laser display and also has the advantages of electric excitation, high efficiency, long life, all solid states, miniaturization, low cost and adjustable color temperature, so that a larger color range coverage of laser display is realized, and the system can be used to satisfy special demands such as large-screen seamless splicing.
Technical Institute of Physics and Chemistry of the Chinese Academy of Sciences (Chine)
Inventeur(s)
Li, Yi
Hao, Qingshan
Chen, Jinping
Zeng, Yi
Yu, Tianjun
Abrégé
Disclosed is a molecular glass of a spirofluorene derivative having a molecular structure as follows: formula (I),
12 can be identical or different, but on the same benzene ring the substituents cannot all be hydrogen atoms. The molecular glass has a good solubility in various polar solvents, is suitable to be made into a film; meanwhile the molecular glass has a very high glass transition temperature and meets the requirements of the photolithography processing technology. Also disclosed is a preparation method of the above-mentioned molecular glass of a spirofluorene derivative. The synthetic process of the method is simple and suitable for industrialization. Further disclosed is the use of a photo-resist with the above-mentioned molecular glass as a main material in photo-etching, wherein the molecular glass of a spirofluorene derivative with hydroxyl groups (or partly with hydroxyl groups) on the periphery thereof can be used as a negative photo-resist, and the molecular glass with the hydroxyl groups on the periphery thereof protected (or partly protected) by an acid-sensitive substituent can be used as a positive photo-resist.
C07C 37/055 - Préparation de composés comportant des groupes hydroxyle ou O-métal liés à un atome de carbone d'un cycle aromatique à six chaînons par remplacement des groupes fonctionnels liés à un cycle aromatique à six chaînons par des groupes hydroxyle, p. ex. par hydrolyse par substitution d'un groupe lié au cycle par un oxygène, p. ex. d'un groupe éther
C07C 43/205 - Éthers une liaison sur l'oxygène de la fonction éther étant sur un atome de carbone d'un cycle aromatique à six chaînons le cycle aromatique n'étant pas condensé
C07C 39/23 - Composés comportant au moins un groupe hydroxyle ou O-métal lié à un atome de carbone d'un cycle aromatique à six chaînons polycycliques contenant des cycles aromatiques à six chaînons et d'autres cycles avec une insaturation autre que celle des cycles aromatiques
C07C 69/96 - Esters de l'acide carbonique ou de l'acide formique halogéné
C07C 41/30 - Préparation d'éthers par des réactions ne formant pas de liaisons sur l'oxygène de la fonction éther par augmentation du nombre d'atomes de carbone, p. ex. par oligomérisation
45.
ANTI-ULTRAVIOLET SHEET-LIKE CELLULOSE MATERIAL AND PREPARATION METHOD AND USE THEREOF
TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (Chine)
Inventeur(s)
Wu, Min
Huang, Yong
Zhao, Mengmeng
Abrégé
Provided is an anti-ultraviolet sheet-like cellulose material, characterized in that: the micro appearance of the cellulose material is sheet-like, the particle size thereof is 5-200 microns and the thickness is 0.01-10 microns, and the sheet-like cellulose material is able to block the transmission of ultraviolet light in the range of UVA (320-400 nm), and UVB (280-320 nm). At the same time, also provided are a method for preparing the sheet-like cellulose material and a use thereof.
B27L 11/00 - Fabrication de copeaux, particules, poudre, ou produits similaires, à partir de boisOutils à cet effet
D21B 1/06 - Matières premières fibreuses ou leur traitement mécanique par division des matières premières en petites particules, p. ex. fibres par procédés à sec
TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (Chine)
Inventeur(s)
Zhi, Jinfang
Wu, Liangzhuan
Abrégé
Disclosed in the present invention is a chemical plating method for preparing a flexible oxide film comprising the following steps: 1) pre-treating a flexible substrate film: impregnating an organic flexible film into a pure solution of a monomer of π-conjugated structure molecules; 2) dissolving a metal hydroxide with an aqueous hydrogen peroxide solution, then diluting by adding water, then adding a catalyst or radiating with an ultraviolet lamp for several minutes, stirring at normal temperature to obtain an aqueous metal peroxide complex solution; 3) impregnating the flexible substrate material obtained in step 1) on which π-conjugated structure molecules are fixed into the solution prepared in step 2), to obtain a flexible function film material. The present method has low preparation costs, strong operability, can achieve the preparation of a crystal oxide film on a flexible substrate with a large area, is suitable for batch preparation, has the possibility of industrial production and has a wide application prospect.
C23C 18/00 - Revêtement chimique par décomposition soit de composés liquides, soit de solutions des composés constituant le revêtement, ne laissant pas de produits de réaction du matériau de la surface dans le revêtementDépôt par contact
47.
GRAPHENE NANOSHEET DISPERSION AND PREPARATION METHOD THEREFOR
TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (Chine)
Inventeur(s)
Wu, Min
Huang, Yong
Kuga, Shigenori
Sun, Peipei
Abrégé
Provided are a graphene nanosheet dispersion and a preparation method therefor. In the dispersion, the graphene nanosheet has a thickness of 0.35 - 7 nm, and is dispersed in a solvent in the form of a single layer or multiple layers. The preparation method comprises the following steps: (1) mixing graphite with a solid polymer proportionally, and grinding mechanically to obtain a mixed powder of graphene nanosheets/solid polymer; (2) adding the mixed powder of graphene nanosheets/solid polymer into a solvent capable of dissolving the polymer, so as to obtain an intermediate of graphene nanosheet dispersion; and (3) removing the solid polymer dissolved in the solvent from the obtained intermediate of the dispersion, so as to obtain the graphene nanosheet dispersion. The polymer is used as a dispersion phase in the method and promotes the stripping of graphite during grinding so as to effectively inhibit the obtained graphene nanosheets from reaggregation. The method is simple and has a low cost.
Technical Institute of Physics and Chemistry of the Chinese Academy of Sciences (Chine)
Inventeur(s)
Wu, Min
Huang, Yong
Kuga, Shigenori
Huang, Pei
Abrégé
A method for preparing stably dispersed cellulose nanofibers comprises the following steps: 1) mixing cellulose and an organic solvent, the percentage of the cellulose being 1% to 15% in weight; 2) adding an esterification agent into the resultant mixture of step 1), the molar ratio of the esterification agent to the cellulose being from 1:0.1 to 4; and 3) physically breaking the resultant mixture of step 2) until a suspension liquid with stably dispersed cellulose nanofibers of 2-1000 nm in diameter and 10-100 μm in length is obtained, an esterification reaction of hydroxyl group(s) on the surface of cellulose fibers occurring at the time of the breaking. Also disclosed are dispersed cellulose nanofibers with improved compatibility to the matrix than the untreated cellulose and an improved strength of the composite materials.
D01F 2/28 - Filaments, ou similaires, artificiels, à un seul composant, formés de cellulose ou de dérivés de la celluloseLeur fabrication à partir de dérivés de la cellulose à partir d'esters ou d'éthers organiques de cellulose, p. ex. à partir d'acétate de cellulose
TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (Chine)
Inventeur(s)
Li, Yi
Hao, Qingshan
Chen, Jinping
Zeng, Yi
Yu, Tianjun
Abrégé
Disclosed is a molecular glass of a spirofluorene derivative having a molecular structure as follows: formula (I), wherein each of R1-R12 is a hydrogen atom, a hydroxyl group, a methoxyl group or an acid-sensitive substituent; substituents R1-R12 can be identical or different, however, on the same benzene ring the substituents cannot all be hydrogen atoms. The molecular glass has good solubility in various polar solvents, is suitable to be made into a film; meanwhile, the molecular glass has a very high glass transition temperature and meets the requirements of photo-etching processing technology. Also disclosed is a preparation method for the above-mentioned molecular glass of a spirofluorene derivative. The synthetic process of the method is simple and suitable for industrialization. Further disclosed is the use of a photo-resist with the above-mentioned molecular glass as a main material in photo-etching, wherein the molecular glass of a spirofluorene derivative with hydroxyl groups (or partly with hydroxyl groups) on the periphery thereof can be used as a negative photo-resist, and the molecular glass with the hydroxyl groups on the periphery thereof protected (or partly protected) by an acid-sensitive substituent can be used as a positive photo-resist.
C07C 69/96 - Esters de l'acide carbonique ou de l'acide formique halogéné
C07C 69/712 - Éthers le groupe hydroxyle de l'ester étant éthérifié par un composé hydroxylé dont le groupe hydroxyle est lié à un atome de carbone d'un cycle aromatique à six chaînons
C07C 43/205 - Éthers une liaison sur l'oxygène de la fonction éther étant sur un atome de carbone d'un cycle aromatique à six chaînons le cycle aromatique n'étant pas condensé
C07C 43/23 - Éthers une liaison sur l'oxygène de la fonction éther étant sur un atome de carbone d'un cycle aromatique à six chaînons contenant des groupes hydroxyle ou O-métal
C07C 39/23 - Composés comportant au moins un groupe hydroxyle ou O-métal lié à un atome de carbone d'un cycle aromatique à six chaînons polycycliques contenant des cycles aromatiques à six chaînons et d'autres cycles avec une insaturation autre que celle des cycles aromatiques
50.
SURFACE PLASMON RESONANCE SENSOR CHIP, AND PREPARATION METHOD AND APPLICATION THEREOF
TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (Chine)
Inventeur(s)
Wang, Pengfei
Lan, Minhuan
Zhang, Hongyan
Abrégé
Disclosed is a surface plasmon resonance sensor chip, comprising a glass substrate layer, a metalized film layer, a probe molecule layer. The metalized film layer is disposed on the glass substrate layer, and the probe molecule layer is disposed on the metalized film layer. Also disclosed is a preparation method of a surface plasmon resonance sensor chip. By means of a surface plasmon resonance spectrum generated by the surface of the metalized film on the glass substrate, content of lipopolysaccharide in an aqueous solution is detected in a fast, convenient, quantitative, and ultra-sensitive way.
C03C 17/38 - Traitement de surface du verre, p. ex. du verre dévitrifié, autre que sous forme de fibres ou de filaments, par revêtement avec au moins deux revêtements ayant des compositions différentes un revêtement au moins étant un métal un revêtement au moins étant une substance organique
TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (Chine)
Inventeur(s)
Wang, Pengfei
Wang, Hui
Liu, Weimin
Wang, Ying
Abrégé
Disclosed is a 9H-thioxanthen-9-one oxide derivative, having a structural formula as represented by formula (1), (2), (3) or (4); in formulas (1) and (2), R1, R2, R3, R4, R5, R6, R7, and R8 are respectively selected from one of hydrogen atom, arylamine group, aryl, and aryl-heterocyclic group; and in formulas (3) and (4), L is one of null, aryl, arylamine group, heterocyclic aryl, and aryl-silane group. Also disclosed are a preparation method and uses of the 9H-thioxanthen-9-one oxide derivative. The 9H-thioxanthen-9-one oxide derivative can be used as the organic luminescent layer of an organic electroluminescent device.
C07D 335/16 - Atomes d'oxygène, p. ex. thioxanthones
C07D 409/04 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
C07D 409/14 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre comme uniques hétéro-atomes du cycle contenant au moins trois hétérocycles
C07D 409/10 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne carbonée contenant des cycles aromatiques
C09K 11/06 - Substances luminescentes, p. ex. électroluminescentes, chimiluminescentes contenant des substances organiques luminescentes
H01L 51/50 - Dispositifs à l'état solide qui utilisent des matériaux organiques comme partie active, ou qui utilisent comme partie active une combinaison de matériaux organiques et d'autres matériaux; Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de tels dispositifs ou de leurs parties constitutives spécialement adaptés pour l'émission de lumière, p.ex. diodes émettrices de lumière organiques (OLED) ou dispositifs émetteurs de lumière à base de polymères (PLED)
52.
PREPARATION METHOD OF HETEROATOM DOPED MULTIFUNCTIONAL CARBON QUANTUM DOT AND APPLICATION THEREOF
TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (Chine)
Inventeur(s)
Wang, Pengfei
Ge, Jiechao
Lan, Minhuan
Liu, Weimin
Abrégé
Disclosed are a preparation method of a heteroatom doped multifunctional carbon quantum dot, and application of the heteroatom doped multifunctional carbon quantum dot in fields of biomedicine, catalysts, and photoelectric devices. The heteroatom carbon quantum dot is prepared by using a conjugated polymer as a predecessor which is processed in a high temperature carbonization process. These carbon quantum dots comprise one or more of heteroatoms, such as N, S, Si, Se, P, As, Ge, Gd, B, Sub-box, and Te, whose absorption spectrum ranges from 300 to 850 nm, and the fluorescence emission wavelength is within a range of 350 to 1000 nm. The carbon quantum dot has a broad application prospect in serving as a new type photosensitizer, preparing photodynamic medicine for heating cancer and sterilization, photocatalytic degradation of organic pollutants, photocatalytic splitting decomposition of water for preparing hydrogen, organic polymer solar cell and quantum dot sensitization solar cell.
TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (Chine)
Inventeur(s)
Wu, Dayong
Sun, He
Wang, Weixi
Liang, Weihua
Abrégé
The present invention relates to a nanofibre lithium-ion battery separator with a composite structure and a preparation method therefor. The battery separator comprises a microporous film intermediate layer having thermal stability, and a first outer layer and a second outer layer which are located at the two sides of the intermediate layer, wherein the first outer layer and the second outer layer are electrospinning sprayed layers. The intermediate layer and the first outer layer and the second outer layer can be further combined through hot-pressing. The porosity of the battery separator is between 40% and 70%. The battery separator according to the present invention can be efficiently prepared in large quantities using large-flow electrospinning technology and equipment, and can be applied to small-sized and power lithium-ion batteries as a high-performance lithium-ion battery separator, to play the roles of increasing the security of batteries, reducing the internal resistance of batteries, prolonging the life cycle of batteries, improving the charging/discharging performance of batteries, etc.
H01M 2/16 - Séparateurs; Membranes; Diaphragmes; Eléments d'espacement caractérisés par le matériau
B32B 3/12 - Produits stratifiés comprenant une couche ayant des discontinuités ou des rugosités externes ou internes, ou une couche de forme non planeProduits stratifiés comprenant une couche ayant des particularités au niveau de sa forme caractérisés par une couche discontinue, c.-à-d. soit continue et percée de trous, soit réellement constituée d'éléments individuels caractérisés par une couche d'alvéoles disposées régulièrement, soit formant corps unique dans un tout, soit structurées individuellement ou par assemblage de bandes indépendantes, p. ex. structures en nids d'abeilles
B32B 5/26 - Produits stratifiés caractérisés par l'hétérogénéité ou la structure physique d'une des couches caractérisés par la présence de plusieurs couches qui comportent des fibres, filaments, grains ou poudre, ou qui sont sous forme de mousse ou essentiellement poreuses une des couches étant fibreuse ou filamenteuse un autre couche également étant fibreuse ou filamenteuse
B32B 37/06 - Procédés ou dispositifs pour la stratification, p. ex. par polymérisation ou par liaison à l'aide d'ultrasons caractérisés par le procédé de chauffage
B32B 37/15 - Procédés ou dispositifs pour la stratification, p. ex. par polymérisation ou par liaison à l'aide d'ultrasons caractérisés par les propriétés des couches avec au moins une couche qui est fabriquée et immédiatement stratifiée avant d'atteindre un état stable, p. ex. dans lesquels une couche est extrudée et stratifiée à l'état semi-pâteux
54.
PREPARATION METHOD OF NEAR-INFRARED FLUORESCENT DYE AND APPLICATION THEREOF
TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (Chine)
Inventeur(s)
Wang, Pengfei
Liu, Weimin
Zhou, Bingjiang
Chen, Jianhong
Zhuang, Xiaoqing
Abrégé
Provided is the near-infrared fluorescent dye having structure (I), wherein Y is O, S or NR11; Z is NR7R8 or OR9; R1, R2, R7, R8, R9, R11, and R14 are independently hydrogen, alkyl, ether group, substituted alkyl, acyl, or aryl; R3, R5, R6, R10, R12, and R13 are independently hydrogen, lower alkyl, lower alkoxy, cyano, or halogen; R4 is hydrogen, lower alkyl, ether group, lower alkoxy, substituted alkyl, acyl, cyano, phenyl, substituted phenyl, or halogen; ΧΘ represents anion. Also provided is a preparation method of the said dye. This kind of dye possesses excellent biocompatibility and photo stability, lower toxicity, longer fluorescent emission and higher fluorescence quantum yield, and is used as covalent or noncovalent fluorescent mark of biomacromolecule.
C09B 11/02 - Colorants des diaryl- ou triarylméthanes dérivés de diarylméthanes
C09B 11/26 - Colorants du triarylméthane dans lesquels au moins un des noyaux aromatiques est un hétérocycle à caractère aromatique
G01N 33/533 - Production de composés immunochimiques marqués avec un marqueur fluorescent
G01N 33/58 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des substances marquées
55.
POLYMER MICRO-NEEDLE ARRAY CHIP, PREPARATION PROCESS AND USE THEREOF
TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (Chine)
Inventeur(s)
Wu, Feipeng
Miao, Yuanhua
Abrégé
Provided is a polymer micro-needle array chip comprising a micro-needle array and a substrate on which the micro-needle array is placed; a polyacrylamide polymer with a molecular weight of 1.0x104-2.0x105, Vickers hardness of 150-600 HV and impact strength of 5-30 J/m is used as the material of the micro-needle array. The polymer micro-needle array chip has high mechanical strength and a sharp needle tip; and it can easily be dissolved or can swell on contact with a water-containing environment, which helps the drug to be released slowly in the skin.
A61M 37/00 - Autres appareils pour introduire des agents dans le corpsPercutanisation, c.-à-d. introduction de médicaments dans le corps par diffusion à travers la peau
A61K 47/32 - Composés macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. carbomères
Technical Institute of Physics and Chemistry of the Chinese Academy of Sciences (Chine)
Inventeur(s)
Duan, Xuanming
Chen, Shu
Cao, Hongzhong
Dong, Xianzi
Zhao, Zhensheng
Abrégé
A laser micro/nano processing system (100, 200, 300, 400) comprises: a laser light source used to provide a first laser beam having a first wavelength and a second laser beam having a second wavelength different from the first wavelength, with the pulse width of the first laser beam being in the range from a nanosecond to a femtosecond; an optical focusing assembly used to focus the first laser beam and the second laser beam to the same focal point; and a micro mobile platform (21) controlled by a computer. Also disclosed are a method for micro/nano-processing photosensitive materials with a laser and a method for fabricating a device with a micro/nano structure using laser two-photon direct writing technology. In the system and methods, spatial and temporal overlapping of two laser beams is utilized, so as to obtain a micro/nano structure with a processing resolution higher than that of a single laser beam, using an average power lower than that of a single laser beam.
H01L 21/00 - Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de dispositifs à semi-conducteurs ou de dispositifs à l'état solide, ou bien de leurs parties constitutives
B81C 1/00 - Fabrication ou traitement de dispositifs ou de systèmes dans ou sur un substrat
B23K 26/06 - Mise en forme du faisceau laser, p. ex. à l’aide de masques ou de foyers multiples
B23K 26/067 - Division du faisceau en faisceaux multiples, p. ex. foyers multiples
B23K 26/08 - Dispositifs comportant un mouvement relatif entre le faisceau laser et la pièce
H01L 21/02 - Fabrication ou traitement des dispositifs à semi-conducteurs ou de leurs parties constitutives
TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (Chine)
Inventeur(s)
Wu, Min
Huang, Yong
Kuga, Shigenori
Huang, Pei
Abrégé
Disclosed is a method for preparing cellulose nanofiber capable of being stably dispersed, comprising the following steps: 1) mixing cellulose and an organic solvent, the solid content of the cellulose being 1% to 15%; 2) adding an esterification agent into the mixture in the step 1), the molar ratio of the esterification agent to the cellulose being from 1: 0.1 to 4; 3) performing physical breaking on all the reaction mixture, an esterification reaction occurring in the hydroxyl on the fibre surface of the cellulose at the same time of the breaking, until a suspension liquid containing stably dispersed cellulose nanofiber with the diameter being 2 to 1000 nm and the length being 100 to 100μm is obtained. Hydrophobization processing is performed, through an alkyl molecular chain, on the surface of the cellulose nanofiber with the surface being esterified obtained through the method of the present invention, so the disperse solvent may be DMF and may also be replaced with other solvents; in addition, during recombination with a synthetic resin, compared with unprocessed cellulose, better compatibility with the matrix is achieved, so the strength of the composite material is improved.
TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (Chine)
Inventeur(s)
Wu, Lizhu
Li, Zhijun
Li, Chengbo
Li, Xubing
Li, Jiaxin
Abrégé
A semiconductor photocatalyst for hydrogen production from biomass derivatives by photocatalytic reforming. The atomic composition ratio thereof is M~N-Ax, wherein M~N is II-VI group elements or III-V group elements, A is one or more of the following elements: cobalt, nickel, iron, copper, chromium, palladium, platinum, ruthenium, rhodium, iridium or silver, and 0.02% ≤ x ≤ 1.0%. The semiconductor photocatalyst is prepared in situ from quantum dots by a photoreaction method without calcination.
TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (Chine)
Inventeur(s)
Wu, Lizhu
Li, Zhijun
Li, Chengbo
Li, Xubing
Li, Jiaxin
Abrégé
Disclosed are a semiconductor photocatalyst for the photocatalytic reforming of biomass derivatives for hydrogen generation, and preparation and use thereof. The semiconductor photocatalyst has the atomic composition ratio of M~N-Ax; wherein M~N are IIB group elements to VIA group elements, or IIIA group elements to VA group elements, A being one element or more than two elements selected from the group consisting of cobalt, nickel, iron, copper, chromium, palladium, platinum, ruthenium, rhodium, iridium and silver; and 0.02% ≤ x ≤ 1.0%. The method of in-situ preparation of the highly effective semiconductor photocatalyst and catalytically reforming biomass derivatives for hydrogen generation by driving photoreaction with visible light via quantum dots is simple, fast, highly effective, inexpensive and practical. The in situ reaction can occur in sunlight without the need of harsh conditions such as calcination.
C01B 3/32 - Production d'hydrogène ou de mélanges gazeux contenant de l'hydrogène par réaction de composés organiques gazeux ou liquides avec des agents gazéifiants, p. ex. de l'eau, du gaz carbonique, de l'air
TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (Chine)
Inventeur(s)
Duan, Xuanming
Chen, Shu
Cao, Hongzhong
Dong, Xianzi
Zhao, Zhensheng
Abrégé
A laser micro/nano processing system (100, 200, 300, 400) comprises: a laser light source used to provide a first laser beam having a first wavelength and a second laser beam having a second wavelength different from the first wavelength, with the pulse width of the first laser beam being in the range from a nanosecond to a femtosecond; an optical focusing assembly used to focus the first laser beam and the second laser beam to the same focal point; and a micro mobile platform (21) controlled by a computer. Also disclosed are a method for micro/nano-processing photosensitive materials with a laser and a method for fabricating a device with a micro/nano structure using laser two-photon direct writing technology. In the system and methods, spatial and temporal overlapping of two laser beams is utilized, so as to obtain a micro/nano structure with a processing resolution higher than that of a single laser beam, using an average power lower than that of a single laser beam.
TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (Chine)
Inventeur(s)
Wu, Dayong
Wang, Haiyan
Cao, Jianhua
Abrégé
An electrospinning membrane machine in warp and weft directions comprises a control unit, a spinning unit and an auxiliary unit and the application process thereof are disclosed. A spinneret group in warp direction (5) and a spinneret group in weft direction (6) of the spinning unit are alternately arranged in longitudinal and transverse direction, reciprocatingly transfer, and spin fibers above the membrane collector. A high voltage electric field is applied between the spinneret groups and a stainless steel conveyer. The macromolecule polymer solution conveyed to the nozzles of the spinneret groups split into nano-jets, and then the nano-jets are collected on the conveyer under high voltage. The nano-jets form membrane on the conveyer and are transported. This machine could not only produce monolayer nano-fiber membrane, but also produce multilayer complex nano-fiber membrane.
TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (Chine)
Inventeur(s)
Gao, Yunhua
Abrégé
A micro-fluid sample boat with solution storage chamber and pump , including: a chamber channel layer, a chamber channel sealing layer, a printing circuit plate jointing with magnetic sensitive sensor chip, a fluid inlet ; A waste pool ,a reaction detection chamber, a solution storage chamber and a pump and micro-channel are provided in the chamber channel layer; the said solution storage chamber and pump includes a sample storage chamber and a reagent storage chamber, the said chamber channel sealing layer and the chamber channel layer are aligned with each other and sealed ,by which the whole waste pool, reaction detection chamber, sealable solution inlet solution storage chamber and pump and micro-channel are formed. Since elastic seals are provided in the solution storage chamber, solutions in the chamber are pushed by an outer pressure into the micro-channels. Thus, the sample boat is convenient for qualitative measurement and usage.
G01N 33/53 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet
G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
G01N 27/72 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant des variables magnétiques
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
63.
AN APPARATUS FOR AUTO-DETECTION OF MAGNETIC SENSITIVE BIOCHIP
TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (Chine)
Inventeur(s)
Gao, Yunhua
Abrégé
An apparatus for auto-detection of magnetic sensitive biochip , includes : a suppress device which applies the press to the sample closet on the biochip's sample boat directly or indirectly; a liquid injection system for injecting the liquid into the micro-fluid channels; the biochip in the micro-fluid channels , which integrates magnetic sensitive sensors ; the device produces the magnetic field ; the electron device for controlling the chip and selecting the information ; the microprocessor and the user interface.
G01N 33/48 - Matériau biologique, p. ex. sang, urineHémocytomètres
G01N 27/72 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant des variables magnétiques