The invention relates to a modular device for the controlled culture of biofilms and the application of mechanical stress to the biofilms, which comprises: a culture chamber comprising a culture dish having a plurality of cylindrical forms, at least one inlet gas port and gas outlet port and at least one fluid inlet port and one fluid outlet port; at least one sensor of an atmospheric variable, positioned inside the culture chamber and which includes at least a temperature sensor; temperature control means; and a control module operatively connected to the sensor and to the control means. The device also comprises agitation means with a guide positioned inside the culture chamber, and an agitation element for applying mechanical stress to the biofilms.
C12M 1/02 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens d'agitationAppareillage pour l'enzymologie ou la microbiologie avec des moyens d'échange de chaleur
C12M 1/04 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens d'introduction de gaz
C12M 1/06 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens d'introduction de gaz avec agitateur, p. ex. avec agitateur à turbine
C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies
C12Q 1/04 - Détermination de la présence ou du type de micro-organismeEmploi de milieux sélectifs pour tester des antibiotiques ou des bactéricidesCompositions à cet effet contenant un indicateur chimique
C12Q 1/18 - Test de l'activité antimicrobienne d'un matériau
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
2.
PHARMACEUTICAL COMBINATION AND USE THEREOF FOR THE TREATMENT OF CANCER AND/OR CHEMORESISTANT CANCER
The present invention relates to an alternative for treating cancer and/or chemoresistant cancer associated with chronic inflammation of an individual who has said disease and it is carried out through combination therapy or the use of a pharmaceutical combination comprising an antineoplastic agent, an antiviral agent and an extract from the Buddleja globosa Hope plant.
A61K 36/00 - Préparations médicinales de constitution indéterminée contenant du matériel provenant d'algues, de lichens, de champignons, ou de plantes, ou leurs dérivés, p. ex. médicaments traditionnels à base de plantes
The present invention discloses a bilayer membrane that promotes bone regeneration and prevents post-operative complications. Said membrane is resorbable, has an antibacterial effect, and is formed by an outer layer and an inner layer that is in contact with the outer layer and in contact with the area to be treated. The outer layer of the membrane comprises a polyhydroxybutyrate (PHB)-based polymer and silver nanoparticles (AgNP), and the inner layer of the membrane comprises calcitriol-loaded polycaprolactone (PCL).
A61F 2/00 - Filtres implantables dans les vaisseaux sanguinsProthèses, c.-à-d. éléments de substitution ou de remplacement pour des parties du corpsAppareils pour les assujettir au corpsDispositifs maintenant le passage ou évitant l'affaissement de structures corporelles tubulaires, p. ex. stents
A61L 27/44 - Matériaux composites, c.-à-d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent comportant une matrice macromoléculaire
4.
DEVICE WITH INCREASED AREA OF IMPACT THAT ALLOWS FOR THE BURNING OR DESTRUCTION OF BIOLOGICAL MATERIAL IN A GASEOUS FLUID
The invention relates to a device (1000) with an increased area of impact which allows for the burning or destruction of biological material in aerosols, in the air or in a gaseous fluid, and which comprises an external casing (1) with a suction unit (100), a unit for the expansion and outlet of gases (400), a sterilising using (300) located inside the external casing between the suction unit and the unit for the expansion and outlet of gases, with the sterilising unit having a sterilising chamber (2) with one or more heating means (40) and a metal sponge (3) which fills the sterilising chamber and is heated by the one or more heating means, and a supply and control unit (300) that is operatively connected to the one or more heating means.
A61L 2/02 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet utilisant des phénomènes physiques
A61L 2/04 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet utilisant des phénomènes physiques de la chaleur
A61L 9/00 - Désinfection, stérilisation ou désodorisation de l'air
A61L 9/16 - Désinfection, stérilisation ou désodorisation de l'air utilisant des phénomènes physiques
A system for detecting, obtaining images and treating or eliminating tumours, diseases or other anomalies, excited by X-rays biomarked with metallic nanoparticles having an external support with a shield having a confocal system with a shielded external structure containing a convergent scan X-ray, a detection system, a second convergent treatment device connected to the confocal structure, and a supporting structure that contains the convergent scan X-ray device, the detection system and the second convergent treatment device; a controlled 3D scanning structure that moves a bed and/or focal point; an electronic control system with programmable electronics allowing operation of the convergent beam device, of the sensors and the movements of the 3D scanning system; and a computed tomography (CT) device with collimators, an X-ray tube and sensors.
A61B 6/00 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations
A61B 6/10 - Moyens de sécurité spécialement adaptés à cet effet
A61B 6/40 - Agencements pour générer des radiations spécialement adaptés au diagnostic par radiations
A61N 5/10 - RadiothérapieTraitement aux rayons gammaTraitement par irradiation de particules
8.
GRANULATED ADDITIVE BASED ON TEXTILE FIBRES FROM END-OF-LIFE TYRES (ELT), TYRE POWDER AND ASPHALT BINDER AND METHOD FOR OBTAINING THE PRODUCT AND USE
A solution to the two major problems that exist today, on the one hand, by recovering the textile fibers extracted from the recycling and Processing of ELTs and, on the other hand, by providing the asphalt paving industry with an alternative mixture with superior performance to that of existing conventional mixtures. More specifically, a granulated additive based on textile fibers and rubber powder from end-of-life tires, having (a) 20% to 30% of textile fiber composed mainly of polyamide or polyester fibers, which together are of the order of 10% by weight of an ELT, (b) 20% to 50% of asphalt binder, (c) 25% to 45% of rubber powder from end-of-life tires in a fraction smaller than 0.5 mm, and (d) 3% to 10% of rubber powder from end-of-life tires in a fraction smaller than 0.18 mm. In addition, the method for obtaining same and its use in asphalt mixtures.
Composition for photodynamic therapy comprising a photosensitiser in combination with ethylenediaminetetraacetic acid (EDTA) and epigallocatechin galate (EGCG), in pharmacologically acceptable carriers and/or excipients. The photosensitising compounds are selected from protoporphyrin IX (PpIX) precursors, such as methyl aminolevulinate (MAL) or aminolevulinic acid (ALA). These new formulations show an enhancing effect of the effect of the photosensitising compounds, MAL or ALA for example, which ensures a greater efficiency of photodynamic therapy, in the treatment of skin or mucous membranes. In one application, the invention is useful in the resolution of long-term preneoplastic or neoplastic dermatological lesions, decreasing the recurrence rates of these lesions.
AcinetobacterSerratiaBacillusBacillus sp.; a method for preparing same; and a use and method applying same, to inhibit the development of diseases caused by plant pathogens and to promote plant growth.
A01N 63/00 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des micro-organismes, des virus, des champignons microscopiques, des animaux ou des substances produites par, ou obtenues à partir de micro-organismes, de virus, de champignons microscopiques ou d'animaux, p. ex. enzymes ou produits de fermentation
A01N 63/20 - BactériesSubstances produites par des bactéries ou obtenues à partir de celles-ci
A method for growing and isolating lactic acid bacteria (LAB) from complex samples, comprising four steps: a) Fermentation; b) Inoculation of an MRS agar medium supplemented with calcium carbonate (CaCO3) and sorbic acid with an aliquot obtained in a); c) Culturing the plates inoculated in step b) under microaerophilia conditions; and d) Selecting colonies by visual inspection and seeding on MRS agar by streaking under microaerophilia conditions.
A device for concentrating ionizing radiation fluence is disclosed having a coupling structure linking the external radiotherapy device with linear accelerator to an external structure, whose central axis is hollow with an input window through which electrons enter attaching to the rotation device; a rotation system linking the coupling structure with a coupling flange rotating an inner structure; a deflection system in the inner structure, wherein the deflection system has first and second magnetic deflection devices; a system for controlling the focal point, which is in the electron deflection system, having an electronic control system controlling a set of motors that produce coordinated movements of the second magnetic deflection device, a correction element and a collimator, which change the position of the focal point; and at least two laser diodes on the edge of the collimator (25) pointing towards the focal point determining the position of the electron beam generated.
G21K 1/093 - Déviation, concentration ou focalisation du faisceau par des moyens électriques ou magnétiques par des moyens magnétiques
G21K 1/02 - Dispositions pour manipuler des particules ou des rayonnements ionisants, p. ex. pour focaliser ou pour modérer utilisant des diaphragmes, des collimateurs
A method for human sperm vitrification is disclosed, which includes providing liquefied human sperm; having a vitrification medium, where the vitrification medium has (a) a sperm buffer, and (b) a cryoprotectant mixture including a permeable cryoprotectant and a non-permeable cryoprotectant; mixing the liquefied sperm with the vitrification medium; providing a sperm straw and loading the straw with 0.25 to 0.5 mL of the obtained mixture; sealing the straw with heat; and placing the straw vertically in a container with liquid nitrogen to vitrify the mixture. A portable kit is also disclosed, which makes it easy to implement the method. The kit includes a vitrification medium, some straws, a container, usage instructions, among others.
The present invention discloses a stable anti-oxidant pigment extract enriched with anthocyanins and hydroxycinnamic acid derivatives (HCAD) obtained from dyed potato pulp. The extract comprises 20-35 mg/L of petunidin-3-caffeoyl rutinoside-5-glucoside, 140-165 mg/L of petunidin-3-coumaroyl rutinoside-5-glucoside, 5-15 mg/L of petunidin-3-ferruloyl rutinoside-5-glucoside and 5 – 15 mg/L of pentunidin derivative among the anthocyanins and 10-20 mg/L of 3-caffeoylquinic acid and 180-210 mg/L of 5-caffeoylquinic acid among the hydroxycinnamic acid derivatives (HCAD). Compositions comprising said extracts for use as a functional additive and/or dye in processed foods are also provided.
A23L 5/43 - Adjonction de colorants ou de pigments, p. ex. en combinaison avec des azurants optiques en utilisant des colorants ou des pigments organiques d'origine naturelle, leurs doublons artificiels ou leurs dérivés
A23L 19/12 - Produits à base de fruits ou de légumesLeur préparation ou leur traitement de tubercules ou d'autres racines contenant de l'amidon de pommes de terre
A23L 33/105 - Extraits de plantes, leurs doublons artificiels ou leurs dérivés
C09B 61/00 - Colorants naturels préparés à partir de sources naturelles
15.
INTEGRAL SYSTEM OF ORTHOVOLTAGE SOURCES THAT INDUCE IONISING RADIATION
The invention relates to a system for detecting, obtaining images and treating or eliminating tumours, diseases or other anomalies, which is excited by means of X-rays biomarked with metallic nanoparticles and which comprises an external support structure (600) with a shield, which comprises: a confocal system (1000) comprising a shielded external structure (67, 75) that contains a convergent scan X-ray device (100), a detection system (200) for X-ray photons with collimators that are solidly connected to and confocal with the first device, a second convergent treatment device (300) solidly connected to the confocal structure (100 and 200), and a supporting structure (400) that contains the convergent scan X-ray device (100), the detection system (200) and the second convergent treatment device (300), which project to a single focal point, and which ensures that same are confocal; a controlled 3D scanning structure (500) that moves a bed and/or focal point onto which ionising radiation is concentrated; an electronic control system comprising programmable electronics (700) that allow the operation of the convergent beam device, the operation of the sensors (2) and the movements of the 3D scanning system; and a computed tomography (CT) device (2000) comprising collimators, an X-ray tube and sensors and which is incorporated into the structure (600). The invention further relates to an associated method.
G01N 23/00 - Recherche ou analyse des matériaux par l'utilisation de rayonnement [ondes ou particules], p. ex. rayons X ou neutrons, non couvertes par les groupes , ou
G01N 23/02 - Recherche ou analyse des matériaux par l'utilisation de rayonnement [ondes ou particules], p. ex. rayons X ou neutrons, non couvertes par les groupes , ou en transmettant la radiation à travers le matériau
G01N 23/04 - Recherche ou analyse des matériaux par l'utilisation de rayonnement [ondes ou particules], p. ex. rayons X ou neutrons, non couvertes par les groupes , ou en transmettant la radiation à travers le matériau et formant des images des matériaux
G01N 23/041 - Imagerie en contraste de phase, p. ex. en utilisant des interféromètres à réseau
G01N 23/044 - Recherche ou analyse des matériaux par l'utilisation de rayonnement [ondes ou particules], p. ex. rayons X ou neutrons, non couvertes par les groupes , ou en transmettant la radiation à travers le matériau et formant des images des matériaux en utilisant la laminographie ou la tomosynthèse
G01N 23/046 - Recherche ou analyse des matériaux par l'utilisation de rayonnement [ondes ou particules], p. ex. rayons X ou neutrons, non couvertes par les groupes , ou en transmettant la radiation à travers le matériau et formant des images des matériaux en utilisant la tomographie, p. ex. la tomographie informatisée
G01N 23/22 - Recherche ou analyse des matériaux par l'utilisation de rayonnement [ondes ou particules], p. ex. rayons X ou neutrons, non couvertes par les groupes , ou en mesurant l'émission secondaire de matériaux
G01N 23/223 - Recherche ou analyse des matériaux par l'utilisation de rayonnement [ondes ou particules], p. ex. rayons X ou neutrons, non couvertes par les groupes , ou en mesurant l'émission secondaire de matériaux en irradiant l'échantillon avec des rayons X ou des rayons gamma et en mesurant la fluorescence X
16.
GRANULATED ADDITIVE BASED ON TEXTILE FIBRES FROM END-OF-LIFE TYRES (ELT), TYRE POWDER AND ASPHALT BINDER AND METHOD FOR OBTAINING THE PRODUCT AND USE
The present invention provides a solution to the two major problems that exist today, on the one hand, by recovering the textile fibres extracted from the recycling and processing of ELTs and, on the other hand, by providing the asphalt paving industry with an alternative mixture with superior performance to that of existing conventional mixtures. More specifically, the invention discloses a granulated additive based on textile fibres and rubber powder from end-of-life tyres, which comprises: (a) 20% to 30% of textile fibre composed mainly of polyamide or polyester fibres, which together are of the order of 10% by weight of an ELT, (b) 20% to 50% of asphalt binder, (c) 25% to 45% of rubber powder from end-of-life tyres in a fraction smaller than 0.5 mm, and (d) 3% to 10% of rubber powder from end-of-life tyres in a fraction smaller than 0.18 mm. In addition, the method for obtaining same and its use in asphalt mixtures are disclosed.
A composition for photodynamic therapy which comprises a photosensitiser in combination with ethylenediaminetetraacetic acid (EDTA) and epigallocatechin galate (EGCG), in pharmacologically acceptable carriers and/or excipients. The photosensitising compounds are chosen from protoporphyrin IX (PpIX) precursors, such as methyl aminolevulinate (MAL) or aminolevulinic acid (ALA). These new formulations show an enhancing effect of the effect of the photosensitising compounds, for example MAL or ALA, thereby ensuring the greater effectiveness of photodynamic therapy in the treatment of skin or mucous membranes. In one application, the invention is useful in the resolution of long-term preneoplastic or neoplastic skin lesions, reducing the rate of recurrence of these lesions.
A61K 31/197 - Acides carboxyliques, p. ex. acide valproïque ayant un groupe amino les groupes amino et carboxyle étant liés à la même chaîne carbone acyclique, p. ex. acide gamma-aminobutyrique [GABA], bêta-alanine, acide epsilon-aminocaproïque ou acide pantothénique
A61K 31/198 - Alpha-amino-acides, p. ex. alanine ou acide édétique [EDTA]
A61K 31/221 - Esters, p. ex. nitroglycérine, sélénocyanates d'acides carboxyliques d'acides acycliques, p. ex. pravastatine avec des composés ayant un groupe amino, p. ex. acétylcholine, acétylcarnitine
A61K 31/353 - 3,4-Dihydrobenzopyranes, p. ex. chromane, catéchine
A61K 41/00 - Préparations médicinales obtenues par traitement de substances par énergie ondulatoire ou par rayonnement corpusculaire
A61N 5/06 - Thérapie par radiations utilisant un rayonnement lumineux
A61P 17/12 - Kératolytiques, p. ex. préparations pour le traitement des verrues ou des cors
An in situ measuring instrument of the convergence angle (CA) of a dental preparation or stump in the field of dentistry, applied to humans or other species, having a movable bar, and a support bar arranged parallel to each other and coupled perpendicularly and slidable relative to a central bar by a first guiding hole at one end of the central bar and a second guiding hole at one end of the support bar which allow the relative vertical movement of the movable bar and horizontal movement of the support bar, allowing both bars to be adjusted to the base of the stump. This instrument allows measuring both natural and artificial teeth and implants, as well as fixed and mobile prostheses, just as if any device attached to the tooth (artificial or implant) is desired to be installed.
G01B 3/56 - Calibres pour mesurer des angles ou des conicités, p. ex. compas à calibrer conique
G01B 5/24 - Dispositions pour la mesure caractérisées par l'utilisation de techniques mécaniques pour mesurer des angles ou des cônesDispositions pour la mesure caractérisées par l'utilisation de techniques mécaniques pour tester l'alignement des axes
19.
DEVICE FOR CONCENTRATING IONISING RADIATION FLUENCE, WHICH FOCUSES ELECTRONS AND X-RAY PHOTONS AND IS ADAPTABLE
The invention relates to a device for concentrating ionising radiation fluence (500) with variable focal point, adaptable to a high-energy electron source of an external radiotherapy device with linear accelerator, in order to focus and guide the focal point in a continuous, less invasive manner, within a predetermined zone, which comprises: a coupling structure linking the external radiotherapy device with linear accelerator to an external structure (101), whose central axis (5) is hollow with an input window (6) through which electrons enter and anchoring means for attaching to the rotation device by means of fastening means (4); a rotation system which links to the coupling structure with a coupling flange (8) and rotates an inner structure (102); a deflection system (503) for deflecting electrons which is in the inner structure (102), wherein the deflection system (503) comprises first and second magnetic deflection devices (13, 14); a system for controlling the focal point, which is in the electron deflection system (503), comprising an electronic control system (31) that controls a set of motors (12, 22) that produce coordinated movements of the second magnetic deflection device (14), a correction element and a collimator (25), which make it possible to change the position of the focal point; and at least two laser diodes (74) located on the edge of the collimator (25) pointing towards the focal point, making it possible to determine the position of the electron beam generated.
G21K 1/00 - Dispositions pour manipuler des particules ou des rayonnements ionisants, p. ex. pour focaliser ou pour modérer
G21K 1/02 - Dispositions pour manipuler des particules ou des rayonnements ionisants, p. ex. pour focaliser ou pour modérer utilisant des diaphragmes, des collimateurs
H05G 2/00 - Appareils ou procédés spécialement adaptés à la production de rayons X, n'utilisant pas de tubes à rayons X, p. ex. utilisant la génération d'un plasma
The invention relates to a variable-focus device (100) for concentrating ionising radiation fluence, which can be adapted to a high-energy electron source of an external radiotherapy device having a linear accelerator, to focus and guide the focus continuously and less invasively, within a determined area, which comprises: a coupling structure that joins the external radiotherapy device having a linear accelerator to an exterior structure (101); a rotation system joined to the coupling structure using a coupling flange (8), which causes an interior structure (102) to rotate; an electron deflection system (103) in the interior structure (102), the deflection system (103) comprising a first magnetic deflection device (13) and a second magnetic deflection device (14); elements (104) for correcting an electron beam; a heat-dissipation disc (26) comprising a white ring (19), the electrons from the deflection system (103) hitting the perimeter of the ring, X-rays being generated there; a shield (20); a focus control system in the electron deflection system (103), which comprises an electronic control system (31) that controls a set of motors (12, 22) that generate coordinated movements of the second magnetic deflection device (14), a correction element and a collimator (25), which allow the position of the focal point to be changed; and at least one laser diode (74) located on the edge of the collimator (25), pointing to the focus, thereby allowing the position of the X-ray beam generated to be determined.
G21K 1/02 - Dispositions pour manipuler des particules ou des rayonnements ionisants, p. ex. pour focaliser ou pour modérer utilisant des diaphragmes, des collimateurs
Chlamydia trachomatis, Ureaplasma urealitycum, Mycoplasma hominis, Mycoplasma genitalium, and Human papillomavirus (HPV); a method for simultaneously detecting at least seven silent sexually transmitted diseases (SSTDs).
C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
C12Q 1/689 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les bactéries
C12Q 1/686 - Réaction en chaine par polymérase [PCR]
22.
NATURAL BLECHNUM CHILENSE EXTRACT, WITH IMMUNOSUPPRESIVE AND ANTI-INFLAMMATORY ACTIVITY FOR INHIBITING THE LYMPHOCYTE ACTIVATION ASSOCIATED WITH AUTO-IMMUNE AND INFLAMMATORY DISEASES AND THE REJECTION OF TISSUES IN TRANSPLANT PATIENTS
636366 and undetermined core terpenes, it has been determined that it has a potential immunomodulator effect like polidin, butanediol, limonene, 5 Cl-phenyl trimethyl and an antioxidant effect like gamma-glutamyl methionine. In addition, the results indicate that Blechnum chilense does not have a cytotoxic effect on CD3+ T lymphocytes, of both human and murine origins, which was determined by means of the analysis of the total extract in a dosage range of 0.1ug/ml to 500 ug/ml, and that the methanolic and aqueous extracts in a dosage range of 10 ug/ml to 100 ug/ml demonstrate a clear inhibiting of lymphocyte proliferation, with CD3+ T lymphocytes of both human and murine origins not affecting the lymphocyte viability (see attached figures). In this way, the invention proposes a natural plant extract of Blechnum chilense containing bioactive secondary metabolites with immunosuppressive activity which inhibits the activation of T lymphocytes.
The present invention describes a method for the vitrification of human semen, which comprises: providing liquid human semen; providing a vitrification medium, the vitrification medium comprising: (a) a semen buffer medium, and (b) a mixture of cryoprotectors comprising a permeable cryoprotector and a non-permeable cryoprotector; mixing the liquid semen with the vitrification medium; providing a semen straw and loading said straw with 0.25-0.5 mL of the obtained mixture; heat-sealing the straw; and inserting the straw in a vertical position into a receptacle with liquid nitrogen to vitrify the mixture. The present invention also provides a portable kit which simplifies the implementation of the method, the kit comprising, inter alia, a vitrification medium, straws, a receptacle, and use instructions.
The invention relates to an instrument for in situ measurement of the angle of convergence (AC) of a dental preparation or stump (20) in the field of dentistry, applied to human beings or another species, which comprises a movable bar (2) and a supporting bar (3) arranged parallel to one another and coupled perpendicular and slidable relative to a central bar (1) by means of a first guiding hole at one end of the central bar and a second guiding hole at one end of the supporting bar (3), which allow the relative vertical movement of the movable bar (2) and the relative horizontal movement of the supporting bar (3), allowing the two bars (2 and 3) to be adjusted to the base of the stump (20), in which the movable bar (2) is arranged so as to rest on the outer-mouth wall of the stump by means of a vertical movement relative to the central bar (1), a first screw (6) makes it possible to fix the position of the movable bar, the supporting bar (3) is arranged so as to be adjusted in contact with the base of the stump (20) by means of a horizontal movement relative to the central bar (1), a second screw (7) makes it possible to fix the position of the supporting bar, at the distal end of the supporting bar (3) is mounted a measurement rod (4) that is straight, thin and Y-shaped with parallel upper ends, and that can pivot about a pin (12), a double ruler (5) on either side of the supporting bar (3) is graded with angles, and the upper ends of the measurement rod (4) can pass over the ruler (5) allowing the reading of the AC from both sides, by simple parallax.
A61C 19/04 - Instruments de mesure spécialement adaptés à la technique dentaire
A61C 5/10 - Procédés ou dispositifs pour la fabrication des couronnes dentaires
G01B 3/00 - Instruments de mesure caractérisés par l'utilisation de techniques mécaniques
G01B 3/56 - Calibres pour mesurer des angles ou des conicités, p. ex. compas à calibrer conique
G01B 5/00 - Dispositions pour la mesure caractérisées par l'utilisation de techniques mécaniques
G01B 5/24 - Dispositions pour la mesure caractérisées par l'utilisation de techniques mécaniques pour mesurer des angles ou des cônesDispositions pour la mesure caractérisées par l'utilisation de techniques mécaniques pour tester l'alignement des axes
25.
KIT FOR DETECTING SILENT SEXUALLY TRANSMITTED DISEASES (SSTDS) IN A URINE SAMPLE
A diagnostic kit for detecting at least seven silent sexually transmitted diseases (SSTDs) simultaneously comprising: a diagnostic strip comprising detection zones with at least eight probes with sequences SEQ ID nos. 3, 6, 9, 12, 15, 18, 21, 24; at least 14 primers with sequences SEQ ID nos. 1, 2, 4, 5, 7, 8, 10, 11, 13, 14, 16, 17, 19, 20, 22, 23; an instruction manual; a set of nucleotide sequences for detecting at least seven silent sexually transmitted diseases (SSTDs) simultaneously; use of said kit to detect at least the following pathogens: herpes virus type 1, herpes virus type 2, Chlamydia trachomatis, Ureaplasma urealitycum, Mycoplasma hominis, Mycoplasma genitalium, and human papillomavirus (HPV); a method for detecting at least seven silent sexually transmitted diseases (SSTDs) simultaneously.
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
26.
SEEDLING GROWTH-PROMOTING COMPOSITION, A KIT, A METHOD FOR APPLYING THE FORMER, AND USE OF THE VOLATILE ORGANIC COMPOUNDS COMPRISING THE COMPOSITION
The present invention relates to plant growth-promoting compounds and, in particular, the use of volatile organic compounds, such as 2-nonanone, 2-undecanone, 2-tridecanone and 2-pentadecanone, hereinafter referred to as 2K-4, which exhibit growth-inducing activity. Said compounds are applied to crops prior to transplanting them into the field as they strengthen roots by inducing root growth (length of primary root, length of secondary roots, length and density of root hairs) and leaf growth (leaf weight), thereby decreasing stress in the crops due to the change of environment, in other words decreasing the probability of dependency of growth on soil type and change of environment.
A01N 63/02 - Substances produites par, ou obtenues à partir de micro-organismes ou d'animaux
A01P 21/00 - Régulateurs de croissance des végétaux
A01N 35/02 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés organiques comportant un atome de carbone possédant deux liaisons à des hétéro-atomes, avec au plus une liaison à un halogène, p. ex. un radical aldéhyde contenant des groupes aldéhyde ou cétone, ou leurs thio-analogues, liés aliphatiquementLeurs dérivés, p. ex. acétals
27.
POLYPEPTIDE SPERM STABILISER FOR SEMEN USED IN ARTIFICIAL INSEMINATION
The invention relates to: a polypeptide sperm bio-stabiliser FB-sp having the following sequence of amino acids: RPGLPVFSPL; the use of said polypeptide bio-stabiliser for preserving the gametes of animals; a composition comprising said polypeptide bio-stabiliser; a conventional or alternative method for artificial insemination involving the use of said composition in conjunction with extender means to be injected into the females of animal species for commercial use.
A61D 19/02 - Instruments ou procédés pour la reproduction ou la fertilisation pour l'insémination artificielle
28.
Bio-additive for heavy oils, which comprises rapeseed oil methyl esters, surfactants, diluents and metal oxides, and use thereof for reducing polluting emissions and as a combustion efficiency bio-enhancer for heavy oils
The present invention relates to a bioadditive for heavy oils that serves to reduce polluting emissions and bio-enhancer of the combustion performance for heavy oils, which comprises methyl esters of raps oil, also called raps biodiesel, in the range of up to 80% v/v, surfactants in the range of up to 80% v/v, diluents in the range of up to 20% v/v and metal oxides between 0.1-5 g/L.
C10L 10/08 - Utilisation d'additifs à des fins particulières dans les combustibles ou les feux pour améliorer le pouvoir lubrifiantUtilisation d'additifs à des fins particulières dans les combustibles ou les feux pour réduire l'usure
C10L 10/12 - Utilisation d'additifs à des fins particulières dans les combustibles ou les feux pour améliorer l'indice de cétane
C10L 1/10 - Combustibles carbonés liquides contenant des additifs
C10L 1/182 - Composés organiques contenant de l'oxygène contenant des groupes hydroxyleLeurs sels
The present invention relates to a method for determining the fatigue resistance of an asphalt mixture by optimally reproducing the stress state of a road surface, said determination being performed by obtaining a fatigue law for the asphalt mixture. The method comprises performing a stress sweep during uniaxial cyclical tension and compression testing on a cylindrical sample, a perimetral cut being made in the centre of the sample to create a fault plane. The invention also relates to a method for obtaining the sample.
G01N 3/00 - Recherche des propriétés mécaniques des matériaux solides par application d'une contrainte mécanique
G01N 3/08 - Recherche des propriétés mécaniques des matériaux solides par application d'une contrainte mécanique par application d'efforts permanents de traction ou de compression
G01N 3/38 - Recherche des propriétés mécaniques des matériaux solides par application d'une contrainte mécanique en appliquant des efforts répétés ou pulsatoires engendrés par des moyens électromagnétiques
30.
BIO-ADDITIVE FOR HEAVY OILS, WHICH COMPRISES RAPESEED OIL METHYL ESTERS, SURFACTANTS, DILUENTS AND METAL OXIDES, AND USE THEREOF FOR REDUCING POLLUTING EMISSIONS AND AS A COMBUSTION EFFICIENCY BIO-ENHANCER FOR HEAVY OILS
The present invention relates to a bio-additive for heavy oils that reduces polluting emissions and acts as a combustion efficiency bio-enhancer for heavy oils, and which comprises: up to 80% v/v rapeseed oil methyl esters, also called rapeseed biodiesel; up to 80% v/v surfactants; up to 20% v/v diluents; and 0.1-5 g/l metal oxides.
C10L 1/10 - Combustibles carbonés liquides contenant des additifs
C10L 1/182 - Composés organiques contenant de l'oxygène contenant des groupes hydroxyleLeurs sels
C10L 10/08 - Utilisation d'additifs à des fins particulières dans les combustibles ou les feux pour améliorer le pouvoir lubrifiantUtilisation d'additifs à des fins particulières dans les combustibles ou les feux pour réduire l'usure
C10L 10/12 - Utilisation d'additifs à des fins particulières dans les combustibles ou les feux pour améliorer l'indice de cétane
A01N 31/04 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés organiques de l'oxygène ou du soufre l'atome d'oxygène ou de soufre étant lié à une chaîne latérale aliphatique d'un système cyclique carbocyclique
A01N 63/04 - Champignons microscopiques; Substances produites par, ou obtenues à partir de champignons microscopiques
32.
FUNGICIDAL COMPOSITION FOR CONTROLLING PHYTOPATHOGENIC DISEASES, COMPRISING A MIXTURE OF THE VOLATILE COMPOUNDS ETHANOL, 3-METHYLBUTANOL, ISOBUTYL ACETATE, ISOAMYL ACETATE AND ALPHA-BISABOLOL, AND THE USE THEREOF FOR INHIBITING THE GROWTH OF THE PATHOGENIC FUNGUS BOTRYTIS CINEREA
The invention relates to a fungicidal composition for controlling phytopathogenic diseases, comprising a mixture of volatile compounds: 14 - 17 % v/v ethanol, 28 - 33 % v/v 3-methylbutanol, 18 - 21 % v/v isobutyl acetate, 17 - 20 % v/v isoamyl acetate, and 13 - 16 % v/v alpha-bisabolol, in relation to the total volume of the composition. The invention also relates to the use of the fungicidal composition in order to inhibit the growth of the pathogenic fungus Botrytis cinerea.
A01N 31/00 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés organiques de l'oxygène ou du soufre
A01N 63/00 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des micro-organismes, des virus, des champignons microscopiques, des animaux ou des substances produites par, ou obtenues à partir de micro-organismes, de virus, de champignons microscopiques ou d'animaux, p. ex. enzymes ou produits de fermentation
33.
CONTROLLED-RELEASE NITROGEN FERTILIZER USING BIOCHAR AS A RENEWABLE SUPPORT MATRIX
This invention is directed to an ecofertilizer comprising a granular organic urea-based controlled release nitrogen fertilizer using biochar as a renewable support matrix. It also relates to a process for the production of a controlled-release nitrogen fertilizer, such as, the ecofertilizer of this invention. Biochar is obtained by low temperature pyrolysis at 300°C of agricultural wastes; and is used as a renewable matrix for nitrogen impregnation. Subsequently, urea impregnated onto biochar is encapsulated using a biodegradable polymer. The encapsulation was carried out by a precipitation method. The controlled-release nitrogen fertilizer developed exhibited substantially complete nitrogen availability as plant nutrient.
The invention relates to the use of a hydroalcoholic plant extract obtained from the Ruta graveolens species in order to prevent and/or treat arterial hypertension, as it exhibits a marked vasodilator effect in vitro and anti-hypertensive effect in vivo, the latter being verified by orally administering the extract to rats in which a hypertensive level has been induced. The extract is orally administered in a lyophilized manner, either in a capsule or directly dissolved in water, with a mainly preventive purpose, but also as a therapeutic agent for the hypertensive level, as there are currently no monotherapies that have an adequate cost-effectiveness ratio. Although there are various types of drugs that are usually used in the treatment of this disease, the efficiency thereof is not adequate and they normally have to be combined, potentially presenting undesirable side effects.
A piece of scientific/technological equipment is presented for the generation of a convergent photon beam for radiotherapy or other applications. This equipment consists of adequately modifying the trajectory of an electron beam from a linear accelerator (LINAC) by applying magnetic and/or electric fields. These electrons perpendicularly impact the surface of a curved material that has a particular curvature ratio (anode), thus generating X-rays. The interaction of the electrons with the atoms of the anode's material generate X-rays with a non-isotropic angular-spatial distribution, with a greater concentration in the focal direction, which is defined by the geometry of the anode. A curved collimator with an adequate curvature ratio is attached to the back of the anode. The collimator is made up of an array of a great number of small holes that point toward the focal point. This device transmits X-rays solely in the focal direction. The Summary Figure presents a typical configuration of the invention that has been presented.
H01J 35/14 - Dispositifs de concentration, de focalisation ou d'orientation du rayon cathodique
H05G 1/58 - Dispositions de commutation permettant de passer d'un mode de fonctionnement à un autre, p. ex. de la radioscopie à la radiographie, de la radioscopie à irradiation
A61N 5/10 - RadiothérapieTraitement aux rayons gammaTraitement par irradiation de particules
G21K 1/02 - Dispositions pour manipuler des particules ou des rayonnements ionisants, p. ex. pour focaliser ou pour modérer utilisant des diaphragmes, des collimateurs
G21K 1/08 - Déviation, concentration ou focalisation du faisceau par des moyens électriques ou magnétiques
Method for cryopreservation of human spermatozoa free from seminal plasma using a fast and simple aseptic vitrification-devitrification process; portable kit for carrying out the method; and use of the same for treatment of disorders related to reproductive failures
2; and devitrifying the sample in a medium of the present invention. The present invention furthermore discloses a portable kit that makes easy to implement the method, said kit comprising vitrification and devitrification solutions in the volumes required to develop the method and the physical support to carry out the same, i.e. the straws. The use of this kit is also disclosed for the treatment of disorders related to reproductive failures.
The invention relates to scientific/technological equipment intended for the generation of a beam of converging photons for use in radiotherapy or other applications. The equipment is used for suitably forming, by means of the application of magnetic and/or electric fields, a beam of electrons originating from a linear accelerator (LINAC), which electrons perpendicularly intercept the surface of a curved material of a particular radius of curvature (anode), thereby generating X-rays. The interaction between the electrons and the atoms of the anode material generates X-rays with a non-isotropic angular distribution having a greater concentration in the focal direction and being defined by the geometry of the anode. A curved collimator is located at the rear part of the anode, said collimator having a suitable radius of curvature and being formed by an arrangement of a large number of small holes pointing towards the focal point. The device allows the transmission of X-rays only in the focal direction. A typical diagram of the invention is provided in the figure.
A61N 5/10 - RadiothérapieTraitement aux rayons gammaTraitement par irradiation de particules
A61B 6/08 - Moyens auxiliaires pour diriger le faisceau de radiations sur un point particulier, p. ex. en utilisant des faisceaux lumineux
38.
METHOD FOR CRYOPRESERVATION OF HUMAN SPERMATOZOA FREE FROM SEMINAL PLASMA USING A FAST AND SIMPLE ASEPTIC VITRIFICATION-DEVITRIFICATION PROCESS; PORTABLE KIT FOR CARRYING OUT THE METHOD; AND USE OF THE SAME FOR TREATMENT OF DISORDERS RELATED TO REPRODUCTIVE FAILURES
The present invention discloses a method for cryopreservation of human spermatozoa: the method comprises providing spermatozoa free from seminal liquid; mixing the spermatozoa with vitrification medium, wherein the main cryoprotectant agent is 0.1 -0.3 M sucrose; placing the sample inside straws and rapidly freezing them; refrigerating the straws with no need of liquid N2; and devitrifying the sample in a medium of the present invention. The present invention furthermore discloses a portable kit that makes easy to implement the method, said kit comprising vitrification and devitrification solutions in the volumes required to develop the method and the physical support to carry out the same, i.e. the straws. The use of this kit is also disclosed for the treatment of disorders related to reproductive failures.
The invention relates to a novel dentifrice composition having anticaries properties, including a combination of propolis, methylparaben, and propylparaben as an active principle. Of these three components, propolis is the main component, the effect thereof being strengthened by smaller amounts of methylparaben and propylparaben, resulting in a composition having high anticaries activity without harmful side effects. Said active components are present in the following percentages relative to the total weight of the dentifrice composition: 2 to 10% of propolis; 0.01 to 0.30% of methylparaben; and 0.01 to 0.15% of propylparaben, wherein the dentifrice composition further includes a fluoride compound and supplementary ingredients typical of such a formulation, such as abrasives, humectants, foaming agents, thickeners, sweeteners, flavorings, and deionized water.
The invention relates to an active agent having contraceptive properties. Said active agent is a molecular fraction of venom from the Latrodectus mirabilis spider. The active agent is a peptide having sequence SEQ ID NO 1 or sequences at least 85% similar, obtained by means of chemical synthesis or recombinant DNA technology. In a preferred embodiment, the active agent having contraceptive properties is a peptide having 10 to 30 amino acids, preferably 20 amino acids. Said preferred embodiment is illustrated by the sequence SEQ ID NO 2 or sequences that are at least 85% similar, obtained by means of chemical synthesis or recombinant DNA technology. The invention likewise relates to a method for obtaining the contraceptive peptide, which includes the cloning of the nucleotide sequence in a microorganism. The contraceptive pharmaceutical composition includes at least one peptide as per above and one or more pharmaceutically acceptable carriers. Lastly, the invention relates to the use of the peptide which can be used to prepare a drug suitable for use as a contraceptive agent and as a spermicidal agent.
C07K 14/435 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
C12N 15/12 - Gènes codant pour des protéines animales
A61K 38/10 - Peptides ayant de 12 à 20 amino-acides
A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
