Abrégé

The present invention relates to an antibody binding to an intestinal bacterium, an antigen-binding fragment thereof, and uses thereof. In addition, the present invention discloses a nucleic acid encoding the antibody or the antigen-binding fragment thereof, an expression vector comprising the nucleic acid, a cell comprising the nucleic acid or the expression vector, a pharmaceutical composition comprising the antibody or the antigen-binding fragment thereof, a method for producing the antibody, and a method for treating an inflammatory disease by administering the antibody or the antigen-binding fragment thereof.

Classes IPC  ?

• C07K 16/12 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant de bactéries
• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
• A61P 31/04 - Agents antibactériens
• C12N 5/16 - Cellules animales

Abrégé

An information processing apparatus selects a target sequence variation possessed by a subject and having a risk of being harmful. The information processing apparatus includes a filtering unit that classifies one or more sequence variations specified by sequencing a nucleic acid included in the subject into different categories according to a degree of risk of being harmful on the basis of one or more classification criteria, and a control unit that classifies a base sequence including a sequence variation of which a category to which the sequence variation is to belong is known into each of the categories according to the degree of risk of being harmful on the basis of at least one of the classification criteria, and compares a classification result with the category to which the sequence variation is to belong, an information processing method, and an information processing program.

Classes IPC  ?

• G16B 40/00 - TIC spécialement adaptées aux biostatistiquesTIC spécialement adaptées à l’apprentissage automatique ou à l’exploration de données liées à la bio-informatique, p. ex. extraction de connaissances ou détection de motifs
• G16B 30/00 - TIC spécialement adaptées à l’analyse de séquences impliquant des nucléotides ou des aminoacides

Abrégé

The purpose of the present invention is to provide a composition that is superior for practical use with regard to a ligand for activating NKT cells. A liposome agent according to the present invention is characterized by containing a PEGylated liposome, and is also characterized in that: the PEGylated liposome contains an NKT cell ligand and a liposome-constituting lipid; the NKT cell ligand is an α-galactosylceramide, or an analog thereof, that is specifically recognized by an NKT cell receptor on an NKT cell; and the liposome-constituting lipid contains a choline-containing phospholipid, a PEGylated phospholipid, and a cholesterol-based lipid.

Classes IPC  ?

• A61K 31/7032 - Composés ayant des radicaux saccharide liés à des composés non-saccharide par des liaisons glycosidiques liés à un polyol, c.-à-d. composés ayant plusieurs groupes hydroxyle, libres ou estérifiés, y compris le groupe hydroxyle impliqué dans la liaison glycosidique, p. ex. monoglucosyl-diacylglycérides, acide lactobionique, gangliosides
• A61K 9/1271 - Liposomes non conventionnels, p. ex. liposomes modifiés par un PEG ou liposomes enduits de ou greffés avec des polymères
• A61K 47/14 - Esters d’acides carboxyliques, p. ex. acides gras monoglycérides, triglycérides à chaine moyenne, parabènes ou esters d’acide gras de PEG
• A61K 47/18 - AminesAmidesUréesComposés d’ammonium quaternaireAcides aminésOligopeptides ayant jusqu’à cinq acides aminés
• A61K 47/24 - Composés organiques, p. ex. hydrocarbures naturels ou synthétiques, polyoléfines, huile minérale, gelée de pétrole ou ozocérite contenant des atomes autres que des atomes de carbone, d'hydrogène, d'oxygène, d'halogènes, d'azote ou de soufre, p. ex. cyclométhicone ou phospholipides
• A61K 47/28 - Stéroïdes, p. ex. cholestérol, acides biliaires ou acide glycyrrhétinique
• A61P 35/00 - Agents anticancéreux

Abrégé

The present invention provides a production method for an aryl compound that contains a thio group that is substituted with at least one fluorine atom. The present invention is a production method for a fluorinated thio group–containing aryl compound that involves synthesizing a fluorinated thio group–containing aryl compound in which at least one fluorine atom has been introduced into a thio group from a thio group–containing aryl compound represented by general formula (1) (in which A1is a substituted or unsubstituted aryl group or a substituted or unsubstituted heteroaryl group, and R1 is a trityl group, a methoxymethyl group, or a benzoyl group) by means of an oxidation fluorination reaction that uses trichloroisocyanuric acid, an alkali metal fluoride, and potassium bis(trifluoromethanesulfonyl)imide, methanol, or trifluoroacetic acid.

Classes IPC  ?

• C07C 381/00 - Composés contenant du carbone et du soufre et comportant des groupes fonctionnels non couverts par les groupes
• C07C 303/16 - Préparation d'esters ou d'amides d'acides sulfuriquesPréparation d'acides sulfoniques ou de leurs esters, halogénures, anhydrides ou amides d'acides sulfoniques ou de leurs halogénures par oxydation de thiols, de sulfures, d'hydropolysulfures ou de polysulfures, avec formation de groupes sulfo ou halogénosulfonyle
• C07C 309/86 - Halogénures d'acides sulfoniques ayant des groupes halogénosulfonyle liés à des atomes de carbone de cycles aromatiques à six chaînons d'un squelette carboné
• C07C 313/02 - Acides sulfiniquesLeurs dérivés
• C07D 213/70 - Atomes de soufre
• C07D 239/38 - Un atome de soufre
• C07D 239/94 - Atomes d'azote
• C07D 307/85 - Atomes de carbone comportant trois liaisons à des hétéro-atomes avec au plus une liaison à un halogène liés en position 2
• C07D 487/04 - Systèmes condensés en ortho

Abrégé

The present invention addresses the problem of providing a male fish individual having low aggressiveness. The present invention also address the problem of providing a male fish individual having higher growth efficiency. The present invention provides a male fish individual having suppressed functional expression of CYP19a1b (cytochrome P450, family 19, subfamily A, polypeptide 1b).

Classes IPC  ?

• A01K 67/0276 - Vertébrés knock-out
• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
• C12N 15/12 - Gènes codant pour des protéines animales

Abrégé

The present invention provides a polymeric complex comprising a cytokine and a block copolymer represented by the following formula (1). The present invention provides a polymeric complex comprising a cytokine and a block copolymer represented by the following formula (1).

Classes IPC  ?

• A61K 47/64 - Conjugués médicament-peptide, médicament-protéine ou médicament-acide polyaminé, c.-à-d. l’agent de modification étant un peptide, une protéine ou un acide polyaminé lié par covalence ou complexé à un agent thérapeutiquement actif
• A61K 9/107 - Émulsions
• A61K 38/20 - Interleukines
• A61P 35/00 - Agents anticancéreux

Abrégé

A wireless communication device includes: a temperature sensor measuring temperature of concrete within sheathing boards contacting therewith, and transmits signals of the temperature sensor by radio; a flange including a bottom surface flushing with a contact surface of an opening being formed in the sheathing boards; an insertion portion in a tapered conical shape protruding to an inside of a formwork from the flange, and holding the temperature sensor; a head portion with a diameter less than that of the flange exposing to an outside of the formwork from the flange, the wireless communication device is integrated with the concrete whereby: the head portion is fixed by means of a fixing tool until the formwork has not been separated; and the insertion portion is held by hardened and contracted concrete after the formwork has been separated.

Classes IPC  ?

• G01K 1/14 - SupportsDispositifs de fixationDispositions pour le montage de thermomètres en des endroits particuliers
• G01K 1/024 - Moyens d’indication ou d’enregistrement spécialement adaptés aux thermomètres pour l’indication à distance
• G01N 33/38 - BétonChauxMortierPlâtreBriquesProduits céramiquesVerre
• H04L 67/12 - Protocoles spécialement adaptés aux environnements propriétaires ou de mise en réseau pour un usage spécial, p. ex. les réseaux médicaux, les réseaux de capteurs, les réseaux dans les véhicules ou les réseaux de mesure à distance

Abrégé

The present invention is a copolymer having a structure represented by a general formula (1) [in the formula, R1 is a fluorine atom, or a perfluoroalkyl group or perfluoroalkoxy group having 1 to 10 carbon atoms which may have —O— between carbon atoms; R2 and R3 each independently represent a hydrogen atom, a halogen atom, an aliphatic hydrocarbon group having 1 to 30 carbon atoms which may have a substituent, or an aryl group which may have a substituent; the R2 and R3 may be linked with each other to form a ring; the aliphatic hydrocarbon group may contain one or more selected from the group consisting of —O—, —Si(CH3)2—, —CO—, and —NH— between carbon atoms; x and y are positive numbers satisfying a relationship of x+y=1; and a filled circle represents a bond]. The present invention is a copolymer having a structure represented by a general formula (1) [in the formula, R1 is a fluorine atom, or a perfluoroalkyl group or perfluoroalkoxy group having 1 to 10 carbon atoms which may have —O— between carbon atoms; R2 and R3 each independently represent a hydrogen atom, a halogen atom, an aliphatic hydrocarbon group having 1 to 30 carbon atoms which may have a substituent, or an aryl group which may have a substituent; the R2 and R3 may be linked with each other to form a ring; the aliphatic hydrocarbon group may contain one or more selected from the group consisting of —O—, —Si(CH3)2—, —CO—, and —NH— between carbon atoms; x and y are positive numbers satisfying a relationship of x+y=1; and a filled circle represents a bond].

Classes IPC  ?

• C08F 214/18 - Monomères contenant du fluor
• C08F 2/48 - Polymérisation amorcée par énergie ondulatoire ou par rayonnement corpusculaire par la lumière ultraviolette ou visible

Abrégé

Provided are: an acquisition method for information pertaining to the size of a nucleic acid included in a virus-derived capsid by using a nanopore device; and a nanopore device and an acquisition device used for said acquisition method.　The nanopore device includes: a substrate that has a first surface and a second surface; a nanopore that penetrates from the first surface toward the second surface and through which the capsid passes; a first chamber member; and a second chamber member. The first chamber member forms, using the first surface, a first chamber filled with a first electrolytic solution. The second chamber member forms, using the second surface, a second chamber filled with a second electrolytic solution.　The acquisition method includes: a capsid passing step for causing the capsid, which is included in the first electrolytic solution or the second electrolytic solution, to pass through the nanopore; and an ion current measurement step for measuring the change in an ion current when the capsid passes through the nanopore.

Classes IPC  ?

• G01N 27/00 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques
• C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies
• C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
• G01N 27/02 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant l'impédance
• G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique

Abrégé

Provided is a novel material for forming an X-ray structure analysis sample of an organic compound.　A material for forming an X-ray structure analysis sample according to the present disclosure contains the metal complex crystal described below. Metal complex crystal: A metal complex crystal which is composed of a metal ion and a ligand that is coordinated to the metal ion. The metal complex crystal has a three-dimensional network structure that has regularly arranged vacancies, and the ligand includes a carboxylic acid-based ligand (c) and a pyridine-based ligand (p) in a combination of [I] or [II] described below. [I] A compound represented by formula (c1) and a compound represented by formula (p1) [II] A compound represented by formula (c2) and a compound represented by formula (p2)

Classes IPC  ?

• G01N 23/20008 - Détails de construction des appareils d’analyse, p. ex. caractérisés par la source de rayons X, le détecteur ou le système optique à rayons XLeurs accessoiresPréparation d’échantillons à cet effet
• C07C 63/28 - Ses sels
• C07D 213/75 - Radicaux amino ou imino, acylés par un acide carboxylique, par l'acide carbonique ou par leurs analogues du soufre ou de l'azote, p. ex. des carbamates
• G01N 23/207 - Diffractométrie, p. ex. en utilisant une sonde en position centrale et un ou plusieurs détecteurs déplaçables en positions circonférentielles

Abrégé

The problem addressed by this invention is to provide a nuclear battery which is lighter in weight and thinner.　Said problem is solved by a nuclear battery that includes a thermoelectric conversion element including: a thermoelectric conversion part demonstrating non-reciprocal conduction based on breakage of space inversion symmetry; and a pair of electrodes provided apart from each other in the thermoelectric conversion part and serving to extract a non-reciprocal thermoelectric signal, wherein at least one of the constituents of the nuclear battery includes a radioactive isotope.

Classes IPC  ?

• G21H 1/10 - Cellules dans lesquelles le rayonnement chauffe une jonction thermo-électrique ou un convertisseur thermo-ionique
• H10N 15/20 - Dispositifs thermoélectriques utilisant le changement thermique de la perméabilité magnétique, p. ex. en opérant au-dessus et en-dessous du point de Curie

Abrégé

Provided is a converter that is capable of suppressing a spike current generated due to capacitors having a potential difference therebetween being connected to each other, thereby being able to reduce conduction loss of switching elements and noise generation.　The converter comprises an inductor L, a plurality of switching elements Q1-Q6, and a plurality of capacitors C1, C2, and Co connected via the switching elements Q1-Q6. A current path of an output current Io passing through the capacitors C1, C2, Co is formed by turn-on of the switching elements Q1-Q6 (complementary turn-on of the switching elements Q1, Q3, Q5 and the switching elements Q2, Q4, Q6). The converter also comprises a sub-inductor Lo inserted into the current path.

Classes IPC  ?

• H02M 3/155 - Transformation d'une puissance d'entrée en courant continu en une puissance de sortie en courant continu sans transformation intermédiaire en courant alternatif par convertisseurs statiques utilisant des tubes à décharge avec électrode de commande ou des dispositifs à semi-conducteurs avec électrode de commande utilisant des dispositifs du type triode ou transistor exigeant l'application continue d'un signal de commande utilisant uniquement des dispositifs à semi-conducteurs
• H02M 3/07 - Transformation d'une puissance d'entrée en courant continu en une puissance de sortie en courant continu sans transformation intermédiaire en courant alternatif par convertisseurs statiques utilisant des résistances ou des capacités, p. ex. diviseur de tension utilisant des capacités chargées et déchargées alternativement par des dispositifs à semi-conducteurs avec électrode de commande

Abrégé

The present invention provides a novel flame-retardant material and flame-retardant sheet including anionically modified pulp. A flame-retardant material and a flame-retardant sheet according to the embodiments include anionically modified pulp in which the counter ions of anionic groups include metal ions, wherein the anionically modified pulp contains anionic groups in the amount of 1.1-3.0 mmol/g as measured after converting all anionic groups to acid type.

Classes IPC  ?

• D21H 11/20 - Fibres modifiées chimiquement ou biochimiquement
• C08B 5/00 - Préparation d'esters cellulosiques d'acides inorganiques
• C08B 5/14 - Sulfate de cellulose
• C08B 11/12 - Alkyl ou cycloalkyléthers à radicaux hydrocarbonés substitués substitués par des radicaux acide substitués par des radicaux carboxyliques
• C08B 15/02 - OxycelluloseHydrocelluloseHydrate de cellulose
• C08B 15/04 - Carboxycellulose, p. ex. préparée par oxydation avec du peroxyde d'azote
• C08L 1/02 - CelluloseCellulose modifiée
• C08L 1/08 - Dérivés de la cellulose
• C09K 21/14 - Substances macromoléculaires
• D06M 13/00 - Traitement des fibres, fils, filés, tissus ou articles fibreux faits de ces matières, avec des composés organiques non macromoléculairesUn tel traitement combiné avec un traitement mécanique

Abrégé

Provided is a material for thermoforming that contains microfibrous cellulose exhibiting thermoformability. A material for thermoforming according to an embodiment of the present invention contains 50 mass % or more of an onium salt-type anion-modified microfibrous cellulose having a number average fiber width of 2-1000 nm.

Classes IPC  ?

• C08L 1/08 - Dérivés de la cellulose
• C08B 15/04 - Carboxycellulose, p. ex. préparée par oxydation avec du peroxyde d'azote
• D21H 11/18 - Fibres hautement hydratées, gonflées ou aptes à être fibrillées
• D21H 15/02 - Pâte ou papier comprenant des fibres ou des matériaux formant des nappes caractérisés autrement que par leur constitution chimique caractérisés par leur configuration

Abrégé

An example cathode electrode that can stably sustain a catalytic reaction producing an olefinic hydrocarbon such as ethylene and an alcohol such as ethanol by a reduction reaction of carbon dioxide over a long term; and a composite of a cathode electrode and a substrate. An example cathode electrode that electrically reduces carbon dioxide, including: copper; and at least one additive element selected from the group consisting of aluminum, boron, gallium, zinc, titanium, and silicon, wherein the copper contains: zerovalent copper; and monovalent copper and/or divalent copper.

Classes IPC  ?

• C25B 11/046 - Alliages
• C25B 1/23 - Oxyde de carbone ou gaz de synthèse

Abrégé

[Problem] To provide a technical improvement for solving or mitigating at least some of the problems of conventional techniques. [Solution] The invention of the present disclosure is based on an unprecedented novel idea of actively changing a charging current, thereby causing the charging current not only to transfer energy, but also to play a role of information transmission. The present disclosure is characterized by comprising an identifying unit that identifies, using second input information or second output information acquired by a second acquisition unit, the identification information of one electric vehicle indicating the second input information having a specific relationship with first output information acquired by a first acquisition unit or the identification information of one charging device indicating the second output information having a specific relationship with first input information. The first output information of a specific charging device or the first input information of a specific electric vehicle varies on the basis of control information for controlling the charging current. The control information causes the charging current to be modulated with a predetermined waveform pattern for a predetermined period.

Classes IPC  ?

• H02J 7/00 - Circuits pour la charge ou la dépolarisation des batteries ou pour alimenter des charges par des batteries
• B60L 53/65 - Surveillance et commande des stations de charge impliquant l'identification des véhicules ou de leurs types de batteries

Abrégé

[Problem] To provide a sheet or the like that has a less pronounced feeling of use when adhered to skin. [Solution] One aspect of the present invention provides a sheet having an adhesion surface that is used facing skin, said sheet including an elastomer and a light scattering material.

Classes IPC  ?

• C08L 21/00 - Compositions contenant des caoutchoucs non spécifiés
• A61B 5/25 - Électrodes bioélectriques à cet effet
• B32B 27/00 - Produits stratifiés composés essentiellement de résine synthétique
• B32B 27/18 - Produits stratifiés composés essentiellement de résine synthétique caractérisée par l'emploi d'additifs particuliers
• C08K 3/01 - Emploi de substances inorganiques en tant qu'adjuvants caractérisées par leur fonction
• C08K 3/22 - OxydesHydroxydes de métaux

Abrégé

The present invention provides a novel metal complex crystal which has regularly arranged vacancies and is capable of forming an X-ray structure analysis sample by fixing an organic compound in the vacancies.　A metal complex crystal according to the present disclosure is composed of a metal ion and a ligand, and the ligand includes a carboxylic acid-based ligand (c) and a pyridine-based ligand (p) in a combination selected from among [I]-[IV] described below. [I] compound (c1) and compound (p1) [II] compound (c1) and compound (p2) [III] compound (c2) and compound (p2) [IV] compound (c2) and compound (p3)

Classes IPC  ?

• C07C 63/333 - Acides diphényldicarboxyliques-4, 4'
• B82Y 35/00 - Procédés ou appareils pour la mesure ou l’analyse des nanostructures
• C07C 233/81 - Amides d'acides carboxyliques ayant des atomes de carbone de groupes carboxamide liés à des atomes de carbone de cycles aromatiques à six chaînons ayant l'atome d'azote d'au moins un des groupes carboxamide lié à un atome de carbone d'un radical hydrocarboné substitué par des groupes carboxyle
• C07D 213/38 - Radicaux substitués par des atomes d'azote liés par des liaisons simples comportant uniquement de l'hydrogène, ou des radicaux hydrocarbonés, liés à l'atome d'azote substituant
• C07D 213/75 - Radicaux amino ou imino, acylés par un acide carboxylique, par l'acide carbonique ou par leurs analogues du soufre ou de l'azote, p. ex. des carbamates
• C07F 3/06 - Composés du zinc
• G01N 23/20025 - Porte-échantillons ou leurs supports
• G01N 23/207 - Diffractométrie, p. ex. en utilisant une sonde en position centrale et un ou plusieurs détecteurs déplaçables en positions circonférentielles

Abrégé

The present invention provides a novel flame-retardant coating agent and flame-retardant sheet including anionically modified fine fibrous cellulose. A flame-retardant coating agent and a flame-retardant sheet according to the embodiments include anionically modified fine fibrous cellulose having a number-average fiber width of 2 to 1,000 nm, wherein counter ions of anionic groups in the anionically modified fine fibrous cellulose include metal ions.

Classes IPC  ?

• C09D 101/02 - CelluloseCellulose modifiée
• C08B 5/00 - Préparation d'esters cellulosiques d'acides inorganiques
• C08B 5/14 - Sulfate de cellulose
• C08B 15/04 - Carboxycellulose, p. ex. préparée par oxydation avec du peroxyde d'azote
• C08L 1/08 - Dérivés de la cellulose

Abrégé

Provided are a fibrous material for thermoforming that contains an anion-modified pulp exhibiting thermoformability, and a composite material for thermoforming. A fibrous material for thermoforming according to an embodiment of the present invention includes an anion-modified pulp in which 45 mol % or more of the anionic group is an onium salt. The composite material for thermoforming according to said embodiment contains an anion-modified pulp in which 45 mol % or more of the anionic group is an onium salt, and a thermoplastic resin.

Classes IPC  ?

• D21H 11/20 - Fibres modifiées chimiquement ou biochimiquement
• C08L 1/08 - Dérivés de la cellulose
• C08L 101/00 - Compositions contenant des composés macromoléculaires non spécifiés

Abrégé

A classification model that outputs identification information indicating whether or not a particle has specific morphological characteristics when waveform data is input is generated by training using training data including first waveform data that is obtained by irradiating light to particles contained in a first sample and having specific morphological characteristics and indicates morphological characteristics of the particles, information indicating that the first waveform data has been obtained from particles contained in the first sample, second waveform data indicating morphological characteristics of unspecified particles contained in a second sample, information indicating that the second waveform data has been obtained from particles contained in the second sample, and a positive rate that is the proportion of particles having the specific morphological characteristics.

Classes IPC  ?

• G01N 15/1429 - Traitement du signal

Abrégé

To provide an antibody that specifically binds to an extracellular domain of human LPA1, wherein the antibody does not specifically bind to an extracellular domain of human LPA2 and does not specifically bind to an extracellular domain of human LPA3. Preferably, the antibody includes an activity of blocking an LPA1-dependent cell function. Also, a nucleic acid encoding the antibody, a cell including the nucleic acid, and a medicament including the antibody as an active ingredient are provided.

Classes IPC  ?

• C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
• A61K 47/68 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un anticorps, une immunoglobuline ou son fragment, p. ex. un fragment Fc

Abrégé

[Problem] [Problem] The present invention provides a dressing material for puncture that allows puncture while observing a blood vessel of a puncture site and a puncture needle with an ultrasound examination device, and allows a puncture device to be directly fixed. Consequently, the present invention provides a dressing material for puncture that avoids entering of air between an adhesive and a skin when the dressing material for puncture is attached and improves not only an ultrasonic transparency but also a moisture permeability. [Problem] The present invention provides a dressing material for puncture that allows puncture while observing a blood vessel of a puncture site and a puncture needle with an ultrasound examination device, and allows a puncture device to be directly fixed. Consequently, the present invention provides a dressing material for puncture that avoids entering of air between an adhesive and a skin when the dressing material for puncture is attached and improves not only an ultrasonic transparency but also a moisture permeability. [Solution] [Problem] The present invention provides a dressing material for puncture that allows puncture while observing a blood vessel of a puncture site and a puncture needle with an ultrasound examination device, and allows a puncture device to be directly fixed. Consequently, the present invention provides a dressing material for puncture that avoids entering of air between an adhesive and a skin when the dressing material for puncture is attached and improves not only an ultrasonic transparency but also a moisture permeability. [Solution] A dressing material for puncture of the present invention includes a support film, a frame sheet, and a release liner, which are laminated from an upper side in this order. An adhesive is used to bond the support film and the frame sheet, and bond the frame sheet and the release liner. The support film is a base material having a thickness of from 10 μm to 80 μm. The adhesive has a mass per unit area of from 30 g/m2 to 80 g/m2.

Classes IPC  ?

• A61F 13/0246 - Bandages ou pansements adhésifs caractérisés par la couche adhérant à la peau
• A61F 13/00 - Bandages ou pansementsGarnitures absorbantes
• A61F 13/02 - Bandages ou pansements adhésifs
• A61M 25/01 - Introduction, guidage, avance, mise en place ou maintien en position des cathéters
• A61M 25/02 - Dispositifs de maintien en position, p. ex. sur le corps

Abrégé

A method of treating systemic sclerosis in a patient administers an IL-23 specific antibody, e.g., guselkumab, at an initial dose and subsequent doses in order for the patient to respond to the antibody and meet one or more of the clinical endpoints.

Classes IPC  ?

• C07K 16/24 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des cytokines, des lymphokines ou des interférons
• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps

Abrégé

The present invention relates to an inflammatory reaction inhibitor that contains sialyllactose or a salt thereof as an active ingredient and suppresses an inflammatory cytokine-induced inflammatory reaction.

Classes IPC  ?

• A61K 31/702 - Oligosaccharides, c.-à-d. ayant trois à cinq radicaux saccharide liés les uns aux autres par des liaisons glycosidiques
• A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]
• A61P 43/00 - Médicaments pour des utilisations spécifiques, non prévus dans les groupes

Abrégé

The present invention addresses the problem of providing a relatively low-molecular compound capable of controlling necroptosis. Provided is an agent for treating a disease or condition that is improved by controlling necroptosis, the agent containing a compound represented by formula I or formula II or a pharmacologically acceptable salt thereof. (In formula I and formula II, each of R1, R2, and R31-61-6 alkyl, and X is H or COR4, R 41-622C=CH-.)

Classes IPC  ?

• A61K 38/05 - Dipeptides
• A61P 43/00 - Médicaments pour des utilisations spécifiques, non prévus dans les groupes
• C12N 5/079 - Cellules neurales
• C12Q 1/06 - Détermination quantitative

Abrégé

This invention provides an antibody that binds specifically to sulfated glycosaminoglycan (sGAG) in a pH-dependent manner. The antibody that binds specifically to sulfated glycosaminoglycan is at least one antibody selected from the group consisting of (1) to (3): (1) an antibody comprising a heavy chain that comprises CDR1 consisting of the amino acid sequence represented by SEQ ID NO: 1, CDR2 consisting of the amino acid sequence represented by SEQ ID NO: 2, and CDR3 consisting of the amino acid sequence represented by SEQ ID NO: 3 and a light chain that comprises CDR1 consisting of the amino acid sequence represented by SEQ ID NO: 4, CDR2 consisting of the amino acid sequence represented by LGS, and CDR3 consisting of the amino acid sequence represented by SEQ ID NO: 6; (2) an antibody comprising a heavy chain that comprises CDR1 consisting of the amino acid sequence represented by SEQ ID NO: 7, CDR2 consisting of the amino acid sequence represented by SEQ ID NO: 8, and CDR3 consisting of the amino acid sequence represented by SEQ ID NO: 9 and a light chain that comprises CDR1 consisting of the amino acid sequence represented by SEQ ID NO: 10, CDR2 consisting of the amino acid sequence represented by AAS, and CDR3 consisting of the amino acid sequence represented by SEQ ID NO: 12; and (3) an antibody comprising a heavy chain that comprises CDR1 consisting of the amino acid sequence represented by SEQ ID NO: 13, CDR2 consisting of the amino acid sequence represented by SEQ ID NO: 14, and CDR3 consisting of the amino acid sequence represented by SEQ ID NO: 15 and a light chain that comprises CDR1 consisting of the amino acid sequence represented by SEQ ID NO: 16, CDR2 consisting of the amino acid sequence represented by WAS, and CDR3 consisting of the amino acid sequence represented by SEQ ID NO: 18.

Classes IPC  ?

• C07K 16/30 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire provenant de cellules de tumeurs
• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
• A61K 47/68 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un anticorps, une immunoglobuline ou son fragment, p. ex. un fragment Fc
• A61P 35/00 - Agents anticancéreux

Abrégé

This microneedle structure comprises needle-shaped sections to be inserted into an object. The needle-shaped sections have a porous structure. The porous structure includes openings in the side surfaces of the needle-shaped sections, and holes through which a liquid to be injected into the object or a liquid received from the object flows. The side-surface opening count, which is the number of openings per 10,000 μm2 in the side surfaces of the needle-shaped sections, is 30 or greater.

Classes IPC  ?

• A61B 5/15 - Dispositifs de prélèvement d'échantillons de sang
• A61M 37/00 - Autres appareils pour introduire des agents dans le corpsPercutanisation, c.-à-d. introduction de médicaments dans le corps par diffusion à travers la peau
• B29C 67/20 - Techniques de façonnage non couvertes par les groupes , ou pour la fabrication d'objets poreux ou cellulaires, p. ex. des mousses plastiques, des mousses alvéolaires
• C08J 9/26 - Mise en œuvre de substances macromoléculaires pour produire des matériaux ou objets poreux ou alvéolairesLeur post-traitement par élimination d'une phase solide d'un objet ou d'une composition macromoléculaire, p. ex. par lessivage

Abrégé

A zinc recovery method includes an alkali fusion step (102) of, at a temperature equal to or higher than a melting point of sodium hydroxide, bringing a material (1) and molten sodium hydroxide being sodium hydroxide (5) or (14) in a molten state into contact with each other to decompose the zinc ferrite contained in the material (1) into zinc oxide components and iron oxide components in the molten sodium hydroxide, a water leaching step (103) of, at a temperature lower than a boiling point of water, bringing water into contact with sodium hydroxide being the molten sodium hydroxide with a decreased temperature, the zinc oxide components, and the iron oxide components and leaching the zinc oxide components in a sodium hydroxide aqueous solution.

Classes IPC  ?

• C25C 1/16 - Production, récupération ou affinage électrolytique des métaux par électrolyse de solutions du zinc, du cadmium ou du mercure
• C22B 3/12 - Extraction de composés métalliques par voie humide à partir de minerais ou de concentrés par lixiviation dans des solutions inorganiques alcalines
• C22B 3/22 - Traitement ou purification de solutions, p. ex. de solutions obtenues par lixiviation par des procédés physiques, p. ex. par filtration, par des moyens magnétiques
• C22B 3/44 - Traitement ou purification de solutions, p. ex. de solutions obtenues par lixiviation par des procédés chimiques
• C25C 7/06 - Conduite ou entretien

Abrégé

The purpose of the present invention is to provide a therapeutic agent and a treatment method that exhibit an excellent therapeutic effect on acute encephalopathy for which no effective treatment method has been found.　The present invention is a therapeutic agent for acute encephalopathy that contains umbilical cord-derived mesenchymal cells. Also, the therapeutic agent for acute encephalopathy is preferably for intravenous administration. Furthermore, the umbilical cord-derived mesenchymal cells are preferably cells prepared from umbilical cord tissue including amniotic membrane, blood vessels, perivascular tissues, and Wharton's jelly.

Classes IPC  ?

• A61K 35/51 - Cordon ombilicalSang de cordon ombilicalCellules souches ombilicales
• A61P 25/00 - Médicaments pour le traitement des troubles du système nerveux

Abrégé

This optical measuring device comprises a light source, an ultrasound wave source, a detector, a control device, and an analysis device. The control device acquires a first speckle image and a second speckle image on the basis of outputs of a detector acquired in a first imaging period and a second imaging period, causes laser light to be emitted in the first imaging period and the second imaging period, and causes oscillation of ultrasound waves from the ultrasound wave source such that the ultrasound waves reach a measuring position. The analysis device calculates a first variation component indicating an amount of variation of speckle in a first region and a second variation component indicating an amount of variation of speckle in a second region between the first speckle image and the second speckle image, and extracts a modulated signal component from the first variation component and the second variation component.

Classes IPC  ?

• G01N 21/17 - Systèmes dans lesquels la lumière incidente est modifiée suivant les propriétés du matériau examiné
• A61B 8/00 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores
• A61B 10/00 - Instruments pour le prélèvement d'échantillons corporels à des fins de diagnostic Autres procédés ou instruments pour le diagnostic, p. ex. pour le diagnostic de vaccination ou la détermination du sexe ou de la période d'ovulationInstruments pour gratter la gorge
• G01N 29/06 - Visualisation de l'intérieur, p. ex. microscopie acoustique
• G01N 29/24 - Sondes

Abrégé

This optical measurement device comprises a light source, an ultrasonic wave source, an imaging device, a control device, and an analysis device. The control device causes the imaging device to image, during first to third imaging periods, signals of laser light that has passed through a region in a light scattering body, and controls imaging timings such that the interval between the first imaging period and the second imaging period and the interval between the second imaging period and the third imaging period are equal. The control device causes first laser light, second laser light, and third laser light to be respectively emitted from the light source during the first imaging period, the second imaging period, and the third imaging period, and causes ultrasonic waves to be generated from the ultrasonic wave source at the emission timing of the third laser light such that the ultrasonic waves arrive at a measurement location. The analysis device extracts modulated signal components by using a signal of the first laser light, a signal of the second laser light, and a signal of the third laser light, which have passed through the region in the light scattering body.

Classes IPC  ?

• G01N 21/17 - Systèmes dans lesquels la lumière incidente est modifiée suivant les propriétés du matériau examiné
• A61B 8/00 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores
• A61B 10/00 - Instruments pour le prélèvement d'échantillons corporels à des fins de diagnostic Autres procédés ou instruments pour le diagnostic, p. ex. pour le diagnostic de vaccination ou la détermination du sexe ou de la période d'ovulationInstruments pour gratter la gorge
• G01N 29/06 - Visualisation de l'intérieur, p. ex. microscopie acoustique
• G01N 29/24 - Sondes

Abrégé

The purpose of the present invention is to improve the efficiency and convenience of analyzing the degree of likelihood that a mutation is one that affects the development or progression of a disease. A common filter unit of an analysis device for selecting a cancer driver mutation in a subject classifies, on the basis of a first classification criteria, each of a plurality of sequence mutations identified by sequencing nucleic acids included in the subject into a rank from among rank MYC1 for which the likelihood of being selected as a target sequence mutation is the highest and ranks MYC2 to MYC4 for which the above likelihood is lower than that for MYC1. A parameter-setting reception unit sets, as a second classification criteria, a classification criteria of having been registered in a database or a list, the second classification criteria being different from the first classification criteria for carrying out classification into rank MYC1. A seed gene filter reclassifies, into rank MYC1, a sequence mutation that satisfies the second classification criteria from among the sequence mutations classified into ranks MYC2 to MYC4. The problem is thereby solved.

Classes IPC  ?

• G16B 20/20 - Détection d’allèles ou de variantes, p. ex. détection de polymorphisme d’un seul nucléotide
• G16B 30/00 - TIC spécialement adaptées à l’analyse de séquences impliquant des nucléotides ou des aminoacides
• G16B 40/20 - Analyse de données supervisée

Abrégé

Provided is a novel compound that is promising as a probe for nuclear medical examination. The compound is represented by the following general formula (I) or a salt thereof. Provided is a novel compound that is promising as a probe for nuclear medical examination. The compound is represented by the following general formula (I) or a salt thereof.

Classes IPC  ?

• A61K 51/04 - Composés organiques
• C07C 233/05 - Amides d'acides carboxyliques ayant des atomes de carbone de groupes carboxamide liés à des atomes d'hydrogène ou à des atomes de carbone acycliques ayant les atomes d'azote des groupes carboxamide liés à des atomes d'hydrogène ou à des atomes de carbone de radicaux hydrocarbonés non substitués avec des atomes de carbone de groupes carboxamide liés à des atomes de carbone d'un squelette carboné saturé acyclique ayant les atomes d'azote des groupes carboxamide liés à des atomes d'hydrogène ou à des atomes de carbone acycliques
• C07D 207/16 - Atomes de carbone comportant trois liaisons à des hétéro-atomes, avec au plus une liaison à un halogène, p. ex. radicaux ester ou nitrile
• C07H 3/02 - Monosaccharides
• C07H 15/04 - Radicaux acycliques non substitués par des structures cycliques liés à un atome d'oxygène d'un radical saccharide

Abrégé

A robot system includes an end effector configured to hold a workpiece, an operation device connected to the end effector and configured to operate the end effector, and a control device configured to control an operation of the operation device. The control device controls: a step of assembling the workpiece in a form in which a pressing-target object is sandwiched by arranging the pressing-target object on a first plate jig arranged at a set position and thereafter placing a second plate jig on the first plate jig through operating the end effector; and a step of conveying the workpiece to press position at which the pressing-target object is pressed by holding the pressing-target object, the first plate jig, and the second plate jig altogether as the workpiece with the end effector.

Classes IPC  ?

• B23P 21/00 - Machines pour l'assemblage de nombreuses pièces différentes destinées à composer des ensembles, avec ou sans usinage de ces pièces avant ou après leur assemblage, p. ex. à commande programmée
• B25J 13/06 - Postes de commande, p. ex. pupitres, tableaux de contrôle

Abrégé

psbApsbA gene sequence of the plant, a base substitution that mutates the 219th valine of the D1 protein to another amino acid.

Classes IPC  ?

• C12N 15/82 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules végétales
• A01H 1/00 - Procédés de modification des génotypes
• A01H 5/00 - Angiospermes, c.-à-d. plantes à fleurs, caractérisées par leurs parties végétalesAngiospermes caractérisées autrement que par leur taxonomie botanique

Abrégé

This training device comprises: a first acquisition unit that acquires feed composition information indicating the composition of nutrients in feed; a second acquisition unit that acquires blood amino acid composition information indicating the composition of the blood amino acid of an animal that was given the feed; and a training unit that generates a trained model that has been trained with the corresponding relationship between the composition of nutrients in the feed indicated by the feed composition information and the composition of the blood amino acid indicated by the blood amino acid composition information.

Classes IPC  ?

• G16B 40/20 - Analyse de données supervisée

Abrégé

To accurately perform movement control of a moving body, a machine tool includes a feed driver that moves a moving body in the machine tool, a feedback controller that feedback-controls the feed driver in accordance with a state variable, a friction compensator that, to compensate for rolling friction that occurs in the feed driver, adds, in advance, a friction compensation value obtained from measurement data of rolling friction or a friction compensation value calculated using a rolling friction model to a command value to be input to the feed driver, and a reverse response reducer that reduces, using the state variable of the feedback controller, a reverse response that occurs due to addition of the friction compensation value.

Classes IPC  ?

• B23Q 5/12 - Entraînement mécanique avec des moyens permettant de faire varier les rapports de vitesses

Abrégé

[Problem] To provide an additional use of a polysaccharide derivative such as a tissue adhesive material [Problem] To provide an additional use of a polysaccharide derivative such as a tissue adhesive material [Solution] According to some embodiments, a tissue adhesive material is provided, which is intended to be used for a hard and thick tissue and/or a connective tissue and comprises a polysaccharide derivative having such a structure that a group represented by formula (A) is introduced in an acidic, basic or amphoteric polysaccharide. According to some embodiments, a crosslinked structure and a tissue adhesive material comprising the crosslinked structure are provided, in which the crosslinked structure comprises (a) a polysaccharide derivative having such a structure that a group represented by formula (A) is introduced into an acidic, basic or amphoteric polysaccharide and (b) at least one of an amino-group-containing polymer and an amino-group-containing low-molecular-weight compound each containing at least two primary amino groups, hydrazide groups or aminooxy groups and a group represented by formula (x1), and the crosslinking is achieved by the covalent bonding between a primary amino group, a hydrazide group or an aminooxy group contained in the amino-group-containing polymer and the amino-group-containing low-molecular-weight compound and the group represented by formula (A) contained in the polysaccharide derivative through a Schiff base. According to some embodiments, a tissue adhesive material having a gel-like form is provided, which comprises a polysaccharide derivative having such a structure that a group represented by formula (A-2) is introduced into a polysaccharide containing an amino group, in which the group represented by formula (A-2) is introduced into the polysaccharide by substituting for a hydrogen atom in the amino group in the polysaccharide to form an amide bond.

Classes IPC  ?

• A61L 26/00 - Aspects chimiques des bandages liquides ou utilisation de matériaux pour les bandages liquides
• A61L 24/00 - Adhésifs ou ciments chirurgicauxAdhésifs pour dispositifs de colostomie
• A61L 24/08 - Polysaccharides

Abrégé

The present invention pertains to: a transplantation device capable of encapsulating cells therein; a cell medicine obtained by loading, in advance, a transplantation material containing cells into the transplantation device; a method for producing the cell medicine; etc. More specifically, the present invention pertains to a transplantation device comprising an inner tube and an outer tube. The inner tube is a tubular structural object provided with: a microtube made of a semipermeable membrane that can encapsulate therein a transplantation material containing cells; and an injection part having an injection opening through which cells are supplied into the microtube. The outer tube is an injection needle or cannula provided with a needle tube part having an inner diameter in which the microtube can be accommodated. The inner tube is attached to the outer tube and used. The present invention also pertains to: a cell medicine obtained by loading, in advance, a transplantation material containing cells into the transplantation device; a method for producing the cell medicine; etc.

Classes IPC  ?

• A61F 9/007 - Procédés ou dispositifs pour la chirurgie de l'œil
• A61K 35/30 - NerfsCerveauYeuxCellules cornéennesLiquide céphalorachidienCellules souches neuronalesCellules précurseurs neuronalesCellules glialesOligodendrocytesCellules de SchwannAstrogliesAstrocytesPlexus choroïdeTissu de moelle épinière
• A61P 27/02 - Agents ophtalmiques
• C12M 3/00 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus
• C12N 5/071 - Cellules ou tissus de vertébrés, p. ex. cellules humaines ou tissus humains

Abrégé

A flow path device (1) is provided with: a base (4) having a first surface (4a) and a second surface (4b) that face away from each other; and a pair of first electrode (10) and second electrode (11). The base (4) has a flow path (7) that extends along the first surface (4a) and the second surface (4b), and the pair of first electrode (10) and second electrode (11) form an electric field that intersects the flow path (7) along a direction in which the first surface (4a) and the second surface (4b) face away.

Classes IPC  ?

• B81B 1/00 - Dispositifs sans éléments mobiles ou flexibles, p. ex. dispositifs capillaires microscopiques
• B81C 1/00 - Fabrication ou traitement de dispositifs ou de systèmes dans ou sur un substrat
• G01N 1/10 - Dispositifs pour prélever des échantillons à l'état liquide ou fluide
• G01N 33/48 - Matériau biologique, p. ex. sang, urineHémocytomètres

Abrégé

An ultrasonic generator (10) includes an ultrasonic wave generation source (11), an ultrasonic wave converging portion (12), and a waveguide (13). The waveguide (13) includes a first shaft portion (21), a second shaft portion (22), and a jutting out portion (30). The first shaft portion (21) extends from the ultrasonic wave converging portion (12) to one side in a predetermined direction. The second shaft portion (22) is disposed on the one side in the predetermined direction relative to the first shaft portion (21) and extends in the predetermined direction. The jutting out portion (30) is provided between the first shaft portion (21) and the second shaft portion (22) in the predetermined direction. The jutting out portion (30) juts out more outward than the outer circumferential surfaces of the first shaft portion (21) and the second shaft portion (22) in a plane direction orthogonal to the predetermined direction.

Classes IPC  ?

• G10K 11/28 - Procédés ou dispositifs pour transmettre, conduire ou diriger le son pour focaliser ou pour diriger le son, p. ex. balayage utilisant la réflexion, p. ex. réflecteurs paraboliques

Abrégé

This ion sensor is placed in soil in which measured ions and non-measured ions having the opposite charge to the charge of the measured ions are present, and measures the measured ions. The ion sensor comprises: a substrate; a sensitive film that includes holes, which are ionophores corresponding to the ionic radius of the measured ions; measurement electrodes that are disposed between a substrate main surface and the sensitive film to detect the potential of the sensitive film; and repulsion electrodes that are disposed near the measurement electrodes between the substrate main surface and the sensitive film, to form, on the sensitive film, a repulsive electric field that causes a force repelling the non-measured ions to act.

Classes IPC  ?

• G01N 27/414 - Transistors à effet de champ sensibles aux ions ou chimiques, c.-à-d. ISFETS ou CHEMFETS
• G01N 33/24 - Matériaux de la terre

Abrégé

An ultrasonic wave generation device (10) comprises an ultrasonic wave generation source (11), an ultrasonic wave focusing part (12), and a waveguide (13). The ultrasonic wave focusing part (12) has a first reflection surface (21) that reflects ultrasonic waves generated by the ultrasonic wave generation source (11), and a second reflection surface (22) that reflects the ultrasonic waves reflected by the first reflection surface (21). The ultrasonic wave generation source (11) generates ultrasonic waves of longitudinal waves. The ultrasonic wave generation device (10) is configured such that the ultrasonic waves of longitudinal waves generated from the ultrasonic wave generation source (11) are converted into transverse waves after reflected by the first reflection surface (21) and go to a focus (F). The second reflection surface (22) is located on a path through which the ultrasonic waves reflected by the first reflection surface (21) go to the focus (F). The ultrasonic wave generation device (10) is configured such that the ultrasonic waves reflected by the second reflection surface (22) are converted into longitudinal waves and go to the waveguide (13).

Classes IPC  ?

• H04R 1/34 - Dispositions pour obtenir la fréquence désirée ou les caractéristiques directionnelles pour obtenir la caractéristique directionnelle désirée uniquement en utilisant un seul transducteur avec des moyens réfléchissant, diffractant, dirigeant ou guidant des sons
• H04R 17/00 - Transducteurs piézo-électriquesTransducteurs électrostrictifs

Abrégé

This surface acoustic wave device (10) comprises an ultrasonic wave generation source (11), a reflection unit (12), and a surface wave generation unit (13). The reflection unit (12) comprises a reflection surface (20) formed to generate transverse waves by reflecting an ultrasonic wave generated from the ultrasonic wave generation source (11). The surface wave generation unit (13) generates a surface acoustic wave on a target surface (30) in accordance with introduction of the transverse waves generated on the reflection surface (20). The reflection surface (20) is curved so that the transverse waves generated on the reflection surface (20) converge at a focal point. When a flat region in a base end portion of the targe surface (30) in the propagation direction of the surface acoustic wave is defined as a base end surface (31), the reflection surface (20) and the base end surface (31) are arranged in a positional relationship that falls within a range of angles of 0° or more and less than 90° between a traveling direction (TD1) where the surface acoustic wave travels along the base end surface (31) and directions where at least some of the transverse waves generated on the reflection surface (20) are directed.

Classes IPC  ?

• H04R 17/00 - Transducteurs piézo-électriquesTransducteurs électrostrictifs
• G01N 29/24 - Sondes
• G01N 29/34 - Génération des ondes ultrasonores, sonores ou infrasonores
• G10K 11/30 - Procédés ou dispositifs pour transmettre, conduire ou diriger le son pour focaliser ou pour diriger le son, p. ex. balayage utilisant la réfraction, p. ex. lentilles acoustiques
• G10K 11/36 - Dispositifs pour transformer les ondes acoustiques de surface
• H03H 9/25 - Détails de réalisation de résonateurs utilisant des ondes acoustiques de surface

Abrégé

The present invention addresses the problem of providing a new production method with which it is possible to prepare, with a simpler approach, a hydrogel material having a µm-scale porous structure through which substances such as cells can pass.　It has been found that a biocompatible hydrogel having a µm-scale porous structure can be produced by adopting a freezing-thawing process as a trigger for forming the porous structure, with respect to an initial hydrogel having a non-porous structure generated temporarily, while setting, within a prescribed range, the total concentration of a raw material polymer in a solution.

Classes IPC  ?

• C08J 9/28 - Mise en œuvre de substances macromoléculaires pour produire des matériaux ou objets poreux ou alvéolairesLeur post-traitement par élimination d'une phase liquide d'un objet ou d'une composition macromoléculaire, p. ex. par séchage du coagulum
• A61L 27/18 - Matériaux macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone
• A61L 27/50 - Matériaux caractérisés par leur fonction ou leurs propriétés physiques
• A61L 27/52 - Hydrogels ou hydrocolloïdes
• A61L 27/56 - Matériaux poreux ou cellulaires
• C08G 65/08 - Oxiranes saturés
• C08G 65/333 - Polymères modifiés par post-traitement chimique avec des composés organiques contenant de l'azote
• C08G 65/334 - Polymères modifiés par post-traitement chimique avec des composés organiques contenant du soufre
• C08J 3/24 - Réticulation, p. ex. vulcanisation, de macromolécules
• C08J 3/075 - Gels macromoléculaires

Abrégé

According to an aspect, a detection device includes: a plurality of optical sensors arranged in a detection area; a light source configured to emit light to the optical sensors; an analog front-end (AFE) circuit configured to acquire a detection value of each of the optical sensors; and a signal processing circuit configured to acquire predefined biometric information based on first time-domain data obtained by acquiring the detection values in chronological order. The signal processing circuit is configured to: convert the first time-domain data into a time-domain matrix and perform singular value decomposition on the time-domain matrix, and inversely calculate second time-domain data based on a predetermined singular value among a plurality of singular values obtained as a result of the singular value decomposition; and acquire the biometric information that changes in chronological order as image information using the second time-domain data.

Classes IPC  ?

• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• A61B 5/1455 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang en utilisant des capteurs optiques, p. ex. des oxymètres à photométrie spectrale

Abrégé

[Object] To suppress a decrease in the adsorption performance of an adsorbent containing diatomaceous earth and a basic compound. [Object] To suppress a decrease in the adsorption performance of an adsorbent containing diatomaceous earth and a basic compound. [Solution] An adsorbent for adsorbing an acid gas contains diatomaceous earth, a basic compound, and a saccharide.

Classes IPC  ?

• B01J 20/24 - Composés macromoléculaires d'origine naturelle, p. ex. acides humiques ou leurs dérivés
• B01D 53/50 - Oxydes de soufre
• B01D 53/52 - Sulfure d'hydrogène
• B01J 20/04 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtrationAbsorbants ou adsorbants pour la chromatographieProcédés pour leur préparation, régénération ou réactivation contenant une substance inorganique contenant des composés des métaux alcalins, des métaux alcalino-terreux ou du magnésium
• B01J 20/32 - Imprégnation ou revêtement

Abrégé

The virus of the present disclosure is a multiple mutant virus in which two or more genes of herpes simplex virus type 1 (HSV-1) are modified, and the modification of the gene involves a loss or reduction in gene function.

Classes IPC  ?

• C12N 7/01 - Virus, p. ex. bactériophages, modifiés par l'introduction de matériel génétique étranger
• A61K 39/145 - Orthomyxoviridae, p. ex. virus de l'influenza
• A61K 39/225 - Virus de la gastro-entérite transmissible du porc
• A61K 39/245 - Herpetoviridae, p. ex. virus de l'Herpès simplex
• A61P 31/14 - Antiviraux pour le traitement des virus ARN
• A61P 31/16 - Antiviraux pour le traitement des virus ARN de la grippe ou des rhinovirus
• A61P 31/22 - Antiviraux pour le traitement des virus ADN des virus de l'herpès
• C12N 15/38 - Herpétoviridae, p. ex. virus de l'herpès simplex, herpesvirus varicellae, virus Epstein-Barr, cytomégalovirus, virus de la pseudorage
• C12N 15/44 - Orthomyxoviridae, p. ex. virus de l'influenza
• C12N 15/50 - Coronaviridae, p. ex. virus de la bronchite infectieuse, virus de la gastro-entérite transmissible

Abrégé

The present disclosure addresses the problem of providing: a hydrogen boride-containing sheet production method with which it is possible to obtain a hydrogen boride-containing sheet larger than conventional products; and a hydrogen boride-containing sheet.　The hydrogen boride-containing sheet production method according to an embodiment of the present disclosure comprises: bringing a metal boride into contact with an ion exchange material to obtain hydrogen boride; and heating a mixed liquid containing the obtained hydrogen boride and a liquid medium on a substrate to form a hydrogen boride-containing sheet on the substrate.　The hydrogen boride-containing sheet according to an embodiment of the present disclosure has a length of at least 100 μm in at least one direction.

Classes IPC  ?

• C01B 35/02 - BoreBorures

Abrégé

The purpose of the present invention is to provide a novel non-replicating bovine infectious lymphoma virus (BLV) vaccine. The present invention provides a bovine infectious lymphoma virus (BLV) vaccine in which at least part of the function of the pol gene is deficient. The present invention also provides a method for producing a BLV vaccine, the method including a step for culturing cells that produce non-replicating bovine infectious lymphoma virus (BLV), wherein the non-replicating-BLV-producing cells contain genes of the bovine infectious lymphoma virus (BLV) in which at least a part of the function of the pol gene is deficient. The present invention is advantageous in making it possible to provide a BLV vaccine having high immunogenicity and high safety such that replication does not occur in an infected subject.

Classes IPC  ?

• A61K 39/21 - Retroviridae, p. ex. virus de l'anémie infectieuse équine
• A61P 31/12 - Antiviraux
• A61P 37/04 - Immunostimulants
• C12N 15/48 - Rétroviridae, p. ex. virus de la leucémie bovine, virus de la leucémie féline

Abrégé

dmaenbcabcabcdees are each independently an amino acid or an analog thereof, Z may or may not be present, Z is a peptide including 1-100 amino acids and/or an analog thereof when Z is present, m is an integer selected from 0 to 39, n is an integer selected from 0 to 39, the sum of m and n is an integer selected from 1 to 39, the ring A is a nitrogen-containing six-membered ring which may have a substituent, B1is an oxygen atom, a sulfur atom, or an NH group, R1aabcc, and Z includes at least one amino acid having a prenyl group.

Classes IPC  ?

• C12P 21/04 - Peptides ou polypeptides cycliques ou pontés, p. ex. bacitracine
• C07K 7/54 - Peptides cycliques contenant au moins une liaison peptidique anormale comportant au moins une liaison peptidique anormale dans le cycle
• C07K 14/00 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés
• C12N 9/90 - Isomérases (5.)
• C40B 40/10 - Bibliothèques comprenant des peptides ou des polypeptides ou leurs dérivés

Abrégé

A virus according to the present disclosure is a multiple mutant virus in which not fewer than 2 genes of herpes simplex virus type 2 (HSV-2) are modified, and the modification of said genes causes a loss or reduction of gene function.

Classes IPC  ?

• C12N 7/01 - Virus, p. ex. bactériophages, modifiés par l'introduction de matériel génétique étranger
• A61K 39/245 - Herpetoviridae, p. ex. virus de l'Herpès simplex
• A61P 31/22 - Antiviraux pour le traitement des virus ADN des virus de l'herpès
• A61P 37/04 - Immunostimulants
• C07K 14/035 - Virus de l'herpès simplex I ou II
• C12N 15/38 - Herpétoviridae, p. ex. virus de l'herpès simplex, herpesvirus varicellae, virus Epstein-Barr, cytomégalovirus, virus de la pseudorage

Abrégé

This learning device comprises: a learning image acquisition unit that acquires at least one of a learning moving image, which is a moving image captured by a moving image capturing device for capturing an image in a predetermined frequency region with respect to a first exposed portion of the skin that is exposed of the body of a human serving as a subject, and a learning still image that is a still image captured by a still image capturing device for capturing an image in a predetermined frequency region with respect to a second exposed portion of the skin that is exposed; and a machine learning unit that generates a trained model obtained by performing machine learning of a correspondence relationship between at least one of a first feature quantity extracted on the basis of a temporal waveform corresponding to a pulse detected from the learning moving image acquired by the learning image acquisition unit or a second feature quantity indicating a frequency distribution at the second exposed portion indicated by the learning still image acquired by the learning image acquisition unit, and a feature of being diabetic.

Classes IPC  ?

• G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux

Abrégé

The present invention provides technology that, in a metastatic cancer patient having a peritoneal metastasis and having a separate tumor from the peritoneal metastasis, treats the separate tumor. Provided is a pharmaceutical composition for treating, in a metastatic cancer patient having a peritoneal metastasis and a first tumor at a site other than the peritoneum, the first tumor. The pharmaceutical composition comprises astatine-211 conjugated to a targeting moiety for a tumor-associated antigen expressed on peritoneal metastasis cell surfaces, is administered intraperitoneally, and is administered in combination with an immune checkpoint inhibitor.

Classes IPC  ?

• A61K 51/10 - Anticorps ou immunoglobulinesLeurs fragments
• A61K 33/24 - Métaux lourdsLeurs composés
• A61K 39/395 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire
• A61K 45/00 - Préparations médicinales contenant des ingrédients actifs non prévus dans les groupes
• A61K 47/68 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un anticorps, une immunoglobuline ou son fragment, p. ex. un fragment Fc
• A61P 35/04 - Agents anticancéreux spécifiques pour le traitement des métastases
• A61P 43/00 - Médicaments pour des utilisations spécifiques, non prévus dans les groupes
• C07K 1/107 - Procédés généraux de préparation de peptides par modification chimique de peptides précurseurs
• C07K 16/30 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire provenant de cellules de tumeurs

Abrégé

Provided are a catalyst, which enables the production of a high molecular weight olefin polymer having a polar group and being usable for various applications at a high catalytic activity, and a method for producing such an olefin polymer. Use is made of, as a polymerization catalyst for an olefin having a polar group, a metal complex represented by general formula (C1) [wherein: M represents an element in group 10 of the periodic table; X represents a phosphorus atom (P) or arsenic atom (As); R5 to R11 are as described in claims; at least one of R6 and R7 is an aralkyl group represented by general formula (2) (wherein R12 to R21 are as described in claims); L represents an electron-donating ligand; and q is 0, ½, 1 or 2]. Provided are a catalyst, which enables the production of a high molecular weight olefin polymer having a polar group and being usable for various applications at a high catalytic activity, and a method for producing such an olefin polymer. Use is made of, as a polymerization catalyst for an olefin having a polar group, a metal complex represented by general formula (C1) [wherein: M represents an element in group 10 of the periodic table; X represents a phosphorus atom (P) or arsenic atom (As); R5 to R11 are as described in claims; at least one of R6 and R7 is an aralkyl group represented by general formula (2) (wherein R12 to R21 are as described in claims); L represents an electron-donating ligand; and q is 0, ½, 1 or 2].

Classes IPC  ?

• C08F 10/02 - Éthylène

Abrégé

Disclosed are acid-sensing ion channel (ASIC) inhibitors and their use for treating or inhibiting the development of a condition in which inhibiting an ASIC stimulates or effects treatment or inhibition of the development of the condition. More particularly, this invention relates to proteinaceous ASIC inhibitors and their use for treating or inhibiting the development of a neurological condition, neuronal damage, ischaemia, pain, ischaemia-reperfusion injury, a cancer, chronic kidney disease, acute kidney injury and retinal detachment. The ASIC inhibitors are also useful for inhibiting damage to an organ during organ transplantation.

Classes IPC  ?

• C07K 7/08 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 12 à 20 amino-acides
• A61K 38/00 - Préparations médicinales contenant des peptides
• A61K 38/10 - Peptides ayant de 12 à 20 amino-acides
• A61K 38/12 - Peptides cycliques
• A61P 9/10 - Médicaments pour le traitement des troubles du système cardiovasculaire des maladies ischémiques ou athéroscléreuses, p. ex. médicaments antiangineux, vasodilatateurs coronariens, médicaments pour le traitement de l'infarctus du myocarde, de la rétinopathie, de l'insuffisance cérébro-vasculaire, de l'artériosclérose rénale
• A61P 13/12 - Médicaments pour le traitement des troubles du système urinaire des reins
• A61P 25/00 - Médicaments pour le traitement des troubles du système nerveux
• A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence

Abrégé

2mm-R1(in the formula, R12mm-R2(in the formula, R2s may be the same as or different from each other and are each a substituted or unsubstituted linear or branched hydrocarbon group, a substituted or unsubstituted cyclic hydrocarbon group or a substituted or unsubstituted heterocyclic group, and m is 0-6).

Classes IPC  ?

• C08B 37/00 - Préparation des polysaccharides non prévus dans les groupes Leurs dérivés
• C08L 5/00 - Compositions contenant des polysaccharides ou leurs dérivés non prévus dans les groupes ou

Abrégé

A biodegradable polymer composite material (1) comprises: a base material (10) containing a biodegradable polymer; an enzyme (12) that has the ability to degrade the biodegradable polymer supported on the base material (10); and a biodegradable polymer coating (20) provided on the base material (10).

Classes IPC  ?

• B32B 27/00 - Produits stratifiés composés essentiellement de résine synthétique
• B32B 27/18 - Produits stratifiés composés essentiellement de résine synthétique caractérisée par l'emploi d'additifs particuliers
• C08J 7/04 - Revêtement
• C08L 99/00 - Compositions contenant des composés macromoléculaires naturels ou leurs dérivés, non prévus dans les groupes ou
• C08L 101/00 - Compositions contenant des composés macromoléculaires non spécifiés
• C08L 101/16 - Compositions contenant des composés macromoléculaires non spécifiés les composés macromoléculaires étant biodégradables
• C12N 9/16 - Hydrolases (3.) agissant sur les liaisons esters (3.1)
• D06M 15/507 - Polyesters
• D06M 16/00 - Traitement biochimique des fibres, fils, filés, tissus ou articles fibreux faits de ces matières, p. ex. enzymatique

Abrégé

The present invention provides a novel enzyme. The present invention provides an enzyme or the like for transferring a sugar to queuosine modification in tRNA.

Classes IPC  ?

• C12N 9/10 - Transférases (2.)
• C12Q 1/48 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une transférase

Abrégé

Corvus moneduloidesAccipiter gentilisAccipiter gentilis (Eurasian goshawk) and referred to as R2Cm and R2Ag, respectively, exhibited excellent retrotransposition activities in human cells. These new retrotransposons, as well as engineered versions thereof, can be suitably used for targeted gene delivery.

Classes IPC  ?

• C12N 9/00 - Enzymes, p. ex. ligases (6.)ProenzymesCompositions les contenantProcédés pour préparer, activer, inhiber, séparer ou purifier des enzymes
• C12N 15/63 - Introduction de matériel génétique étranger utilisant des vecteursVecteurs Utilisation d'hôtes pour ceux-ciRégulation de l'expression
• C12N 15/90 - Introduction stable d'ADN étranger dans le chromosome

Abrégé

As one embodiment, the present application discloses a divalent molecule that can bind to both natural AAV capsid and a molecular target. As another embodiment, a method by which high gene transfer efficiency can be achieved in a receptor-dependent manner by using, as a vector, a complex with natural AAV capsid formed using the molecule as an engager is also disclosed. These embodiments contribute to simultaneously achieving two purposes: using natural AAV capsid that has not been modified at all, and dramatically increasing infectivity to target cells. These embodiments are useful, for example, in the field of gene therapy and the like.

Classes IPC  ?

• C07K 19/00 - Peptides hybrides
• C07K 7/50 - Peptides cycliques contenant au moins une liaison peptidique anormale
• C07K 14/015 - Parvoviridae, p. ex. virus de l'aleucémie féline, parvovirus humain
• C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
• C12N 15/864 - Vecteurs parvoviraux

Abrégé

The present invention provides a comprehensive assay capable of comprehensively measuring interactive factors for a variety of different types of proteins. In the present invention, provided is a system for detecting activation of a protein by integrating, with mediation of a plurality of factors, changes in the transcriptional regulatory region of a gene whose expression is changed by activation of the protein. The stimulation response ratio of transcription activity before and after stimulation by ligands possessed by individual transcriptional regulatory regions is synergistically integrated, so that a highly sensitive reporter assay system can be constructed.

Classes IPC  ?

• C12Q 1/06 - Détermination quantitative
• C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
• C12N 15/62 - Séquences d'ADN codant pour des protéines de fusion
• C12N 15/85 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules animales
• C12Q 1/66 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une luciférase

Abrégé

The present invention provides: a novel compound in which some of the eight fluorine atoms of perfluorocubane are substituted with a halogen atom other than a fluorine atom; and a production method for the compound. The present invention relates to: the halogenated cubane compound represented by general formula (1) or (1') [in the formulas, X is an iodine atom, a bromine atom, or a chlorine atom]; and a production method for a halogenated cubane compound in which the halogenated cubane compound represented by general formula (1) or (1') is produced by using a basic catalyst and the halogenation agent represented by general formula (2) [in the formula, X is an iodine atom, a bromine atom, or a chlorine atom and Ar1 is an aryl group which may have a substituent or a heteroaryl group which may have a substituent] to halogenate hexafluorocubane or heptafluorocubane.

Classes IPC  ?

• C07C 23/46 - Hydrocarbures halogénés polycycliques à cycles condensés dont aucun n'est aromatique à plus de trois cycles condensés
• C07B 61/00 - Autres procédés généraux
• C07C 17/10 - Préparation d'hydrocarbures halogénés par remplacement par des halogènes d'atomes d'hydrogène

Abrégé

A level of mouse Aβ1-40 and a level of mouse APP669-711 in a biological sample derived from an AD model mouse are measured by detection of markers including mouse Aβ1-40 and mouse APP669-711; an APP669-711/Aβ1-40 ratio which is a ratio of the level of mouse APP669-711 to the level of mouse Aβ1-40 is calculated; and when the ratio in the AD model mouse is higher than the same ratio in a reference mouse in which cerebral Aβ deposition is absent, it is judged that an amount of cerebral Aβ deposition in the AD model mouse is higher than an amount of cerebral Aβ deposition in the reference mouse.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

Provided is a musical instrument-use resin structure (1) which is used as a musical instrument constituent member or a musical instrument, the musical instrument-use resin structure comprising: a foam section (1b) formed of a foam body; and a covering section (1a) that covers the entire surface of the foam section (1b). Also provided are: a musical instrument constituent member comprising the musical instrument-use resin structure (1); and a musical instrument.

Classes IPC  ?

• G10D 9/08 - Matériaux pour la fabrication d'instruments de musique à ventTraitement des matériaux
• G10D 7/03 - Conception générale des instruments de musique à vent du type dans lequel l'air soufflé est dirigé vers une arête de rampe avec un canal pour diriger l’air soufflé vers le biseau ou le labium, p. ex. flûtes à bec
• G10D 9/035 - Anches

Abrégé

A people flow control evaluation apparatus (100) evaluates an effect of people flow control. A position obtaining unit (110) extracts a position of a target person chronologically from people flow information (20) and stores the position of the target person as chronological position information (41). A direction calculation unit (120) calculates a movement direction of the target person chronologically based on the chronological position information (41) and stores the movement direction of the target person as a chronological movement direction (42). An effect evaluation unit (130) calculates an angular difference between the movement direction of the target person and a direction towards a destination position from the position of the target person chronologically, and evaluates the effect of the people flow control using a chronological change of the angular difference calculated chronologically.

Classes IPC  ?

• G06T 7/73 - Détermination de la position ou de l'orientation des objets ou des caméras utilisant des procédés basés sur les caractéristiques
• G06T 7/246 - Analyse du mouvement utilisant des procédés basés sur les caractéristiques, p. ex. le suivi des coins ou des segments
• G06T 7/60 - Analyse des attributs géométriques
• G06V 20/52 - Activités de surveillance ou de suivi, p. ex. pour la reconnaissance d’objets suspects

Abrégé

Provision of a cell production method, in particular, a method in which carriers are suspended and oscillated in a culture fluid, which is capable of reducing physical stress imposed on animal cells or a transfection reagent and improving cell culture efficiency or transfection efficiency. Provision of a cell production method, in particular, a method in which carriers are suspended and oscillated in a culture fluid, which is capable of reducing physical stress imposed on animal cells or a transfection reagent and improving cell culture efficiency or transfection efficiency. The cell production method includes a culturing step for culturing cells in a culture vessel 2, which holds at least cells, a culture fluid, and a carrier C while the vessel is oscillated on an oscillation plate 102, in which the oscillation plate 102 is tilted only in one direction with respect to a horizontal state.

Classes IPC  ?

• C12M 3/06 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus avec des moyens de filtration, d'ultrafiltration, d'osmose inverse ou de dialyse
• C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
• C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies
• C12M 3/00 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus

Abrégé

Disclosed is a means capable of enhancing the efficiency of formation of a lipid bilayer membrane and the efficiency of introduction of a membrane protein to a lipid bilayer membrane compared with lipid bilayer membrane formation by a conventional droplet contact method. The partition wall for forming a lipid bilayer membrane has a through hole in which a planar lipid bilayer membrane is formed. The planar shape of the through hole has at least a linear portion, and the lipid bilayer membrane formed also has a linear portion. Also provided are: a lipid bilayer membrane formation device having the partition wall for forming a lipid bilayer membrane; a method for forming a lipid bilayer membrane using the device; and a lipid bilayer membrane formed in a through-hole portion of a partition wall, wherein the peripheral edge has a linear portion.

Classes IPC  ?

• B01J 19/00 - Procédés chimiques, physiques ou physico-chimiques en généralAppareils appropriés

Abrégé

Provided is a high-speed variant ChRmine protein having faster kinetic properties compared to a parent ChRmine protein, where the high-speed variant ChRmine protein has one or more amino acid substitutions compared to the parent ChRmine protein. Also provided is a red-shifted variant ChRmine protein having a red-shifted spectrum compared to a parent ChRmine protein, where the red-shifted variant ChRmine protein has one or more amino acid substitutions compared to the parent ChRmine protein. Further provided is a nucleic acid encoding for a variant ChRmine protein disclosed herein as well as a genetically modified cell comprising such nucleic acid. Additionally, provided is an optogenetic method that includes genetically modifying a subject to express in the subject's brain cells a variant ChRmine protein disclosed herein, applying stimulating light to the subject's brain, and imaging the subject's brain.

Classes IPC  ?

• C07K 14/705 - RécepteursAntigènes de surface cellulaireDéterminants de surface cellulaire
• A01K 67/0275 - Vertébrés modifiés génétiquement, p. ex. transgéniques
• C12N 15/86 - Vecteurs viraux
• G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique

Abrégé

It is an object of the present invention to provide an siRNA targeting RecQL1 helicase gene, based on a new target sequence that results in an excellent effect superior to that of conventional siRNAs. Provided is an siRNA targeting RecQL1 helicase gene, consisting of a sense strand comprising the base sequence of SEQ ID NO: 1 and an antisense strand comprising the base sequence of SEQ ID NO: 2.

Classes IPC  ?

• A61K 31/7105 - Acides ribonucléiques naturels, c.-à-d. contenant uniquement des riboses liés à l'adénine, la guanine, la cytosine ou l'uracile et ayant des liaisons 3'-5' phosphodiester
• A61K 31/712 - Acides nucléiques ou oligonucléotides ayant des sucres modifiés, c.-à-d. autres que le ribose ou le 2'-désoxyribose
• A61K 31/7125 - Acides nucléiques ou oligonucléotides ayant des liaisons internucléosides modifiées, c.-à-d. autres que des liaisons 3'-5' phosphodiester
• C12N 5/09 - Cellules tumorales
• C12N 5/10 - Cellules modifiées par l'introduction de matériel génétique étranger, p. ex. cellules transformées par des virus
• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens

Abrégé

The present invention relates to a compound represented by the following Formula (I) or a pharmaceutically acceptable salt thereof: The present invention relates to a compound represented by the following Formula (I) or a pharmaceutically acceptable salt thereof: wherein in Formula (I), definitions of R1, R2, L, m, and n are each shown in the specification.

Classes IPC  ?

• C07F 9/09 - Esters des acides phosphoriques
• A61K 31/685 - Diesters d'acide du phosphore avec deux composés hydroxyle, p. ex. phosphatidylinositols un des composés hydroxylés ayant des atomes d'azote, p. ex. phosphatidylsérine, lécithine
• A61P 1/16 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif des troubles de la vésicule biliaire ou du foie, p. ex. protecteurs hépatiques, cholagogues, cholélitholytiques

Abrégé

A method for isolating and concentrating an extracellular vesicle group derived from a cancer cell involves contacting a substance which has affinity towards a carbohydrate antigen CA19-9 with an extracellular vesicle group which has been isolated from blood derived from a patient, and isolating and concentrating an extracellular vesicle group.

Classes IPC  ?

• C12N 5/09 - Cellules tumorales
• C07K 16/30 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire provenant de cellules de tumeurs
• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer

Abrégé

[Problem] To provide a laminate and similar that have a wide application range. [Solution] One embodiment of the present invention provides a laminate. In this laminate, an electrode, an electrolyte membrane, and an ion transfer layer for transferring ions to and from the electrode are laminated in this order. The electrolyte membrane includes an elastomer and an ionic compound. The average film thickness of the electrolyte membrane is 15 μm or less.

Classes IPC  ?

• B32B 27/00 - Produits stratifiés composés essentiellement de résine synthétique
• B32B 25/14 - Produits stratifiés composés essentiellement de caoutchouc naturel ou synthétique comprenant des copolymères dans lesquels les composants en caoutchouc prédominent
• H01B 1/06 - Conducteurs ou corps conducteurs caractérisés par les matériaux conducteurs utilisésEmploi de matériaux spécifiés comme conducteurs composés principalement d'autres substances non métalliques
• H01M 4/02 - Électrodes composées d'un ou comprenant un matériau actif

Abrégé

Provided are a sepsis determination program, a sepsis determination device, a sepsis determination method, and a sepsis determination system that allow for quick auxiliary diagnosis of sepsis. An acceleration pulse wave of a subject person is acquired, information related to the magnitude of the amplitude of the acquired acceleration pulse wave is identified, whether or not the subject person has sepsis is determined on the basis of the identified information related to the magnitude of the amplitude, and the result of determination as to whether or not there is a possibility that the subject person has sepsis is output.

Classes IPC  ?

• A61B 10/00 - Instruments pour le prélèvement d'échantillons corporels à des fins de diagnostic Autres procédés ou instruments pour le diagnostic, p. ex. pour le diagnostic de vaccination ou la détermination du sexe ou de la période d'ovulationInstruments pour gratter la gorge
• A61B 5/02 - Détection, mesure ou enregistrement en vue de l'évaluation du système cardio-vasculaire, p. ex. mesure du pouls, du rythme cardiaque, de la pression sanguine ou du débit sanguin

Abrégé

33Sn) that has an antiferromagnetic magnetic structure having macroscopically broken time reversal symmetry; and a cap layer (16) which is stacked on the antiferromagnetic layer (14). In the heavy metal layer (12), when a current (I) flows in an in-plane direction, a spin current is generated in a direction perpendicular to the plane, and a spin-orbit torque generated by the spin current acts on the magnetic order of the first antiferromagnetic material of the antiferromagnetic layer (14), thereby controlling the magnetic order. The first antiferromagnetic material of the antiferromagnetic layer (14) has a read signal that responds linearly to a magnetic field within a predetermined magnetic field range including zero magnetic field.

Classes IPC  ?

• G01R 33/07 - Mesure de la direction ou de l'intensité de champs magnétiques ou de flux magnétiques en utilisant des dispositifs galvano-magnétiques des dispositifs à effet Hall
• H10N 52/00 - Dispositifs à effet Hall

Abrégé

[Problem] To improve the operation efficiency of a DC load in accordance with the DC load. [Solution] This power conversion system comprises: a DC/DC converter to which a DC power supply is connectable; a system interconnection inverter; and a DC link connecting the DC/DC converter and the system interconnection inverter. The voltage of the DC link is adjusted in accordance with a DC load connectable to the DC link within a half period of a system voltage on the AC side of the system interconnection inverter.

Classes IPC  ?

• H02M 3/155 - Transformation d'une puissance d'entrée en courant continu en une puissance de sortie en courant continu sans transformation intermédiaire en courant alternatif par convertisseurs statiques utilisant des tubes à décharge avec électrode de commande ou des dispositifs à semi-conducteurs avec électrode de commande utilisant des dispositifs du type triode ou transistor exigeant l'application continue d'un signal de commande utilisant uniquement des dispositifs à semi-conducteurs
• H02M 7/48 - Transformation d'une puissance d'entrée en courant continu en une puissance de sortie en courant alternatif sans possibilité de réversibilité par convertisseurs statiques utilisant des tubes à décharge avec électrode de commande ou des dispositifs à semi-conducteurs avec électrode de commande

Abrégé

This line tracing method uses a sub-driving device (12) that drives a tool (17) in a direction parallel to a processing surface of a workpiece (W) and a main driving device (11) that drives the sub-driving device in three orthogonal-axis directions XYZ for driving the tool (17) along a target trajectory (TT) by the sub-driving device while driving the sub-driving device along a basic trajectory (BT) by the main driving device. When the position of the tool (17) driven by the sub-driving device (12) is included in a limit region of a movable range of the tool in one of the X-axis direction and the Y-axis direction, and the driving direction of the tool driven by the sub-driving device is directed to the limit of the limit region, a driving command value to the sub-driving device with respect to the one of the X-axis direction and the Y-axis direction is reduced.

Classes IPC  ?

• G05B 19/4093 - Commande numérique [CN], c.-à-d. machines fonctionnant automatiquement, en particulier machines-outils, p. ex. dans un milieu de fabrication industriel, afin d'effectuer un positionnement, un mouvement ou des actions coordonnées au moyen de données d'un programme sous forme numérique caractérisée par la programmation de pièce, p. ex. introduction d'une information géométrique dérivée d'un dessin technique, combinaison de cette information avec l'information d'usinage et de matériau pour obtenir une information de commande, appelée programme de pièce, pour la machine à commande numérique [CN]
• G05B 19/19 - Commande numérique [CN], c.-à-d. machines fonctionnant automatiquement, en particulier machines-outils, p. ex. dans un milieu de fabrication industriel, afin d'effectuer un positionnement, un mouvement ou des actions coordonnées au moyen de données d'un programme sous forme numérique caractérisée par systèmes de commande de positionnement ou de commande de contournage, p. ex. pour commander la position à partir d'un point programmé vers un autre point ou pour commander un mouvement le long d'un parcours continu programmé

Abrégé

In a line tracing method that, using a sub-driving device (12) for driving a tool (17) in a direction parallel to a processing surface of a workpiece (W), and a main driving device (11) for driving the sub-driving device in three orthogonal-axis directions XYZ, drives the tool along a target trajectory (TT) by the sub-driving device while driving the sub-driving device along a basic trajectory (BT) by the main driving device, even if the position of the tool is driven in a direction toward a movable origin (12C) of the entire movable range for one of the X-axis direction and the Y-axis direction, the tool is driven in a direction toward the movable origin with respect to the one of the X-axis direction and the Y-axis direction when the processing accuracy by the tool is within a predetermined allowable range.

Classes IPC  ?

• G05B 19/4093 - Commande numérique [CN], c.-à-d. machines fonctionnant automatiquement, en particulier machines-outils, p. ex. dans un milieu de fabrication industriel, afin d'effectuer un positionnement, un mouvement ou des actions coordonnées au moyen de données d'un programme sous forme numérique caractérisée par la programmation de pièce, p. ex. introduction d'une information géométrique dérivée d'un dessin technique, combinaison de cette information avec l'information d'usinage et de matériau pour obtenir une information de commande, appelée programme de pièce, pour la machine à commande numérique [CN]
• G05B 19/19 - Commande numérique [CN], c.-à-d. machines fonctionnant automatiquement, en particulier machines-outils, p. ex. dans un milieu de fabrication industriel, afin d'effectuer un positionnement, un mouvement ou des actions coordonnées au moyen de données d'un programme sous forme numérique caractérisée par systèmes de commande de positionnement ou de commande de contournage, p. ex. pour commander la position à partir d'un point programmé vers un autre point ou pour commander un mouvement le long d'un parcours continu programmé

Abrégé

In this line tracing method, when a tool T is moved along a target trajectory P provided on a main surface of a workpiece W, a trajectory detection device S that moves together with the tool T is used, the trajectory detection device S defines detection areas A1, A2 through which the target trajectory P passes in at least two locations around the tool T, and a target position Pt of the tool T is determined on the basis of the positions P1, P2 of the target trajectory P detected in the detection areas A1, A2, whereby the trace accuracy can be improved even if the target trajectory P is obstructed by the tool T.

Classes IPC  ?

• B23Q 17/24 - Agencements sur les machines-outils pour indiquer ou mesurer utilisant des moyens optiques
• G05B 19/19 - Commande numérique [CN], c.-à-d. machines fonctionnant automatiquement, en particulier machines-outils, p. ex. dans un milieu de fabrication industriel, afin d'effectuer un positionnement, un mouvement ou des actions coordonnées au moyen de données d'un programme sous forme numérique caractérisée par systèmes de commande de positionnement ou de commande de contournage, p. ex. pour commander la position à partir d'un point programmé vers un autre point ou pour commander un mouvement le long d'un parcours continu programmé

Abrégé

The present invention provides a method for producing a highly-pure branched PEG compound, the method comprising: a step (1a) for mixing, in the presence of a solvent, a porous metal complex with a mixture containing a branched PEG compound and, as an impurity, a linear PEG compound to adsorb the linear PEG compound on the porous metal complex; a step (2a) for removing the porous metal complex having adsorbed the linear PEG compound from the mixture containing the branched PEG compound and the porous metal complex having adsorbed the linear PEG compound to obtain a solution containing the branched PEG compound; and a step (3) for recovering the branched PEG compound from the solution containing the branched PEG compound.

Classes IPC  ?

• C08G 65/30 - Traitement de post-polymérisation, p. ex. obtention, purification, séchage
• B01D 15/00 - Procédés de séparation comportant le traitement de liquides par des adsorbants ou des absorbants solidesAppareillages pour ces procédés
• B01J 20/22 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtrationAbsorbants ou adsorbants pour la chromatographieProcédés pour leur préparation, régénération ou réactivation contenant une substance organique

Abrégé

A polarization splitting device includes a substrate, and a polarization splitting layer having a structure element pattern including a plurality of structure elements each having two-fold rotational symmetry, and formed on an upper surface of the substrate. The polarization splitting layer splits first to sixth polarization components included in object light, and focuses respectively at first to sixth focal positions on a focal plane. The structure element pattern includes a first structure element pattern for focusing the first and second polarization components, a second structure element pattern for focusing the third and fourth polarization components, and a third structure element pattern for focusing the fifth and sixth polarization components, and a pattern constituted by a first structure element, a second structure element, and a third structure element is set as a unit pattern, and a plurality of unit patterns are two-dimensionally arranged.

Classes IPC  ?

• G02B 27/28 - Systèmes ou appareils optiques non prévus dans aucun des groupes , pour polariser
• G02B 5/30 - Éléments polarisants
• H04B 10/67 - Dispositions optiques dans le récepteur

Abrégé

[Problem] The present invention addresses the problem of providing a component analysis technique by which, by using a simpler configuration, a target substance, particularly a component contained in a foodstuff, can be efficiently detected through optical response. [Solution] It has been discovered that a multi-equilibrium self-assembled chemosensor system capable of patterning and discerning optical responses of respective target substances can be constructed by using a probe complex formed in a self-assembling manner via a non-covalent bond or a dynamic covalent bond by using three types of building blocks.

Classes IPC  ?

• G01N 21/75 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé
• G01N 21/59 - Transmissivité
• G01N 21/64 - FluorescencePhosphorescence
• G01N 33/02 - Nourriture

Abrégé

An air conditioning system (1) includes a carbon dioxide separation device (20) configured to separate some or all of carbon dioxide from air that contains carbon dioxide, an electrolytic reduction device (30) configured to generate a hydrocarbon and oxygen using the separated carbon dioxide as a raw material, and an oxygen supply amount control device (40) configured to supply some or all of the oxygen generated by the electrolytic reduction device (30) to a space to be processed (10).

Classes IPC  ?

• F24F 8/60 - Traitement, p. ex. purification, de l'air fourni aux locaux de résidence ou de travail des êtres humains autrement que par chauffage, refroidissement, humidification ou séchage en ajoutant de l'oxygène
• C25B 1/02 - Hydrogène ou oxygène
• C25B 3/01 - Produits
• C25B 3/26 - Réduction du dioxyde de carbone
• C25B 15/02 - Commande ou régulation des opérations
• C25B 15/08 - Alimentation ou vidange des réactifs ou des électrolytesRégénération des électrolytes
• F24F 8/10 - Traitement, p. ex. purification, de l'air fourni aux locaux de résidence ou de travail des êtres humains autrement que par chauffage, refroidissement, humidification ou séchage par séparation, p. ex. par filtrage

Abrégé

The present invention provides a method for detecting colorectal cancer in a subject, said method comprising a step for determining the methylation state of at least one of the FGD5 gene and the GPC6 gene in the subject.

Classes IPC  ?

• C12Q 1/686 - Réaction en chaine par polymérase [PCR]
• C12N 15/09 - Technologie d'ADN recombinant
• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer

Abrégé

The present invention addresses the problem of improving user-friendliness and efficiency in analyzing the extent of possibility that there is a mutation that affects the occurrence or progression of disease. A training unit of an information processing system including an analysis device for selecting cancer driver mutations of a test subject uses a plurality of training information sets to execute machine learning by using, as training information sets regarding a prescribed nucleic acid, information indicating known sequence mutations carrying adverse risks, and at least some clinically significant information regarding mutations from among a public database, a human gene polymorphism database, a database pertaining to drug-gene interactions and genome resources for new drug development, and a drug response database. When a prescribed sequence mutation is inputted, the training unit generates or updates an AI model for outputting a ranking of the degree of possibility that said sequence mutation is a target sequence mutation. A rescue filter unit reclassifies, to a higher rank, sequence mutations for which the degree of possibility output by the model is greater than or equal to a certain value. The abovementioned problem is solved through this configuration.

Classes IPC  ?

• G16B 20/20 - Détection d’allèles ou de variantes, p. ex. détection de polymorphisme d’un seul nucléotide
• G16B 30/00 - TIC spécialement adaptées à l’analyse de séquences impliquant des nucléotides ou des aminoacides

Abrégé

[Problem] Provided is an oxyethylene chain-containing polymer having excellent biocompatibility and still having excellent reactivity. [Problem] Provided is an oxyethylene chain-containing polymer having excellent biocompatibility and still having excellent reactivity. [Solution] An oxyethylene chain-containing polymer according to the present invention is represented by the following general formula (1): [Problem] Provided is an oxyethylene chain-containing polymer having excellent biocompatibility and still having excellent reactivity. [Solution] An oxyethylene chain-containing polymer according to the present invention is represented by the following general formula (1): [Problem] Provided is an oxyethylene chain-containing polymer having excellent biocompatibility and still having excellent reactivity. [Solution] An oxyethylene chain-containing polymer according to the present invention is represented by the following general formula (1): (wherein, in the general formula (1), R1 is —(CH2)p—SH, —(CH2)p—N3, (CH2)p—NH2, or —(CH2)p—COOH, and p is an integer of 1 to 5; R2 to R4 are each independently hydrogen or a C1-10 alkyl group; R5 is a C1-10 alkyl group; R6 is hydrogen or a C1-5 alkyl group; R7 is a C1-10 alkyl group; n is an integer of 5 to 1000; m is an integer of 1 to 10; and q is an integer of 0 to 5).

Classes IPC  ?

• C08F 8/34 - Introduction d'atomes de soufre ou de groupes contenant du soufre
• C08F 8/06 - Oxydation
• C08F 8/30 - Introduction d'atomes d'azote ou de groupes contenant de l'azote
• C08F 116/20 - Monomères contenant au moins trois atomes de carbone dans le radical aliphatique non saturé
• C08F 216/20 - Monomères contenant au moins trois atomes de carbone dans le radical aliphatique non saturé

Abrégé

The present invention provides cyclic peptides, as well as methods of using the same, such as for ameliorating or treating a K63Ub-related disease in a subject in need thereof.

Classes IPC  ?

• A61K 38/12 - Peptides cycliques
• C07K 7/64 - Peptides cycliques ne comportant que des liaisons peptidiques normales

Abrégé

Provided are a catalyst and a method that enable the production of an olefin-based polymer, which has a polar group and is usable for various applications, at high catalytic activity. A metal complex shown in general formula (C1) (in the formula, M represents a palladium atom or a nickel atom, X represents a phosphorus atom (P), R5-R9 are as set forth in the claims, L represents an electron donating ligand, and q is 0, ½, 1, or 2) is used as a catalyst for polymerization of an olefin having a polar group.

Classes IPC  ?

• C08F 4/80 - MétauxHydrures métalliquesComposés organiques de métalLeur utilisation comme précurseurs de catalyseurs choisis parmi les métaux non prévus dans le groupe choisis parmi les métaux du groupe du fer ou les métaux du groupe du platine
• C08F 110/02 - Éthylène
• C08F 210/02 - Éthylène

Abrégé

The present invention provides a set of Affibody and photoreceptor protein, wherein the Affibody and the photoreceptor protein form a complex in a manner dependent on light at a wavelength of 600 to 750 nm.

Classes IPC  ?

• C07K 14/195 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de bactéries
• C07K 14/31 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de bactéries provenant de Micrococcaceae (F) provenant de Staphylococcus (G)

Abrégé

The present invention provides a humanized antibody or an antigen-binding fragment thereof that binds to a HEG1 protein, in which the antibody is capable of binding to a human HEG1 protein expressed in mesothelioma cells.

Classes IPC  ?

• C07K 16/30 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire provenant de cellules de tumeurs

Abrégé

One aspect of the present invention provides a cryogenic heat switch. The cryogenic heat switch includes at least one switching portion, a first heat conducting portion, a second heat conducting portion, and a restricting portion. The at least one switching portion is configured to switch between a superconducting state and a normal conducting state upon application of a magnetic field equal to or greater than a critical magnetic field. The at least one switching portion in the normal conducting state has a higher thermal conductivity than the at least one switching unit in the superconducting state. The first heat conducting portion comprises a first base portion coupled to a first member and at least one first switching coupling portion. The at least one first switching coupling portion extends from the first base portion in a first direction and is coupled to a first end of the at least one switching portion. The at least one first switching coupling portion has a rigidity lower than that of the first base portion. The second heat conducting portion comprises a second base portion coupled to a second member and at least one second switching coupling portion. The at least one second switching coupling portion extends from the second base portion in a second direction and is coupled to a second end of the at least one switching portion. The at least one second switching coupling portion has a rigidity lower than that of the second base portion. The restricting portion is coupled to the first base portion and the second base portion without the at least one switching portion being interposed therebetween. The thermal conductivity of the restricting portion is lower than the thermal conductivity of the at least one switching portion in the superconducting state.

Classes IPC  ?

• F25B 9/00 - Machines, installations ou systèmes à compression dans lesquels le fluide frigorigène est l'air ou un autre gaz à point d'ébullition peu élevé
• H10N 60/30 - Dispositifs commutables entre les états supraconducteur et normal

Abrégé

[Problem] The problems addressed are to provide an NA-AP having excellent binding ability to BMP and to reduce the risk of ectopic ossification in bone regeneration treatment utilizing the same. [Solution] An NA-AP having specific binding ability to BMP and a bone regeneration inducing material of said NA-AP carried in a hydrogel were discovered.

Classes IPC  ?

• C12N 15/115 - Aptamères, c.-à-d. acides nucléiques liant spécifiquement une molécule cible avec une haute affinité sans s'y hybrider
• A61K 31/7088 - Composés ayant au moins trois nucléosides ou nucléotides
• A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
• A61L 27/18 - Matériaux macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone
• A61L 27/20 - Polysaccharides
• A61L 27/44 - Matériaux composites, c.-à-d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent comportant une matrice macromoléculaire
• A61L 27/52 - Hydrogels ou hydrocolloïdes
• A61L 27/54 - Matériaux biologiquement actifs, p. ex. substances thérapeutiques
• A61P 19/00 - Médicaments pour le traitement des troubles du squelette

Abrégé

An object of the present invention is to provide a method capable of detecting activity of an enzyme that strictly recognizes a substrate, such as acetylcholinesterase (AChE). There is provided a method for detecting activity of an enzyme in a biological sample using a microdevice, the method including a step of bringing the biological sample into contact with a substrate analog or a natural substrate, and a compound represented by General Formula (I) below or a salt thereof, wherein the substrate analog or the natural substrate generates a compound A having a thiol group (R—SH), a selenol group (R—SeH), or a poly sulfur atom (R—(S)n-H) (R is a hydrogen atom or an alkyl group, and n is 1 to 5) by a reaction with the enzyme, and fluorescence is observed or measured, the fluorescence being emitted or enhanced from a fluorescent product generated by the reaction of the compound represented by General Formula (I) or the salt thereof with the thiol group, the selenol group, or the poly sulfur atom.

Classes IPC  ?

• G01N 21/77 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé en observant l'effet sur un réactif chimique
• C07F 5/02 - Composés du bore
• C07F 7/08 - Composés comportant une ou plusieurs liaisons C—Si
• C12Q 1/34 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une hydrolase
• C12Q 1/46 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une hydrolase une estérase une cholinestérase

Abrégé

66]3-) and a hydrochloric acid solution of divalent copper ions (Cu2+ ions, copper (II) ions) is heated at 80°C for 24 hours to obtain a hydrochloric acid dispersion of the copper-substituted Prussian blue analog, and a step for drying the hydrochloric acid dispersion of the copper-substituted Prussian blue analog to obtain a powder of the copper-substituted Prussian blue analog, and have a particle size of 10-100 nm. In a state where a measurement target for Raman spectroscopy is adsorbed on the surface of the nanoparticles, Raman scattered light from the measurement target in light emitted from a light source is enhanced.

Classes IPC  ?

• G01N 21/65 - Diffusion de Raman

Abrégé

The present invention addresses the problem of providing a continuous long fiber that comprises an aliphatic copolymerized polyester, has excellent storage stability, and can solve a problem of unwinding defects, as well as a method for producing said continuous long fiber. This continuous long fiber comprises an aliphatic copolymerized polyester, wherein the aliphatic copolymerized polyester includes 3-hydroxybutyrate as a first monomer unit and includes 4-hydroxybutyrate or 3-hydroxyvalerate as a second monomer unit, the ratio of the second monomer unit to all monomer units is 1 mol% to 9 mol% when the second monomer unit is the 4-hydroxybutyrate unit, and the ratio of the second monomer unit to all monomer units is 1 mol% to 7.6 mol% when the second monomer unit is 3-hydroxyvalerate.

Classes IPC  ?

• D01F 6/84 - Filaments, ou similaires, faits par l’homme, à un seul composant, formés de polymères synthétiquesLeur fabrication à partir de produits de copolycondensation à partir de copolyesters

Abrégé

A pulsed current drive method according to the present invention involves applying a pulsed current to invert ferroelectric polarization generated by the order and imbalance of ions that have different valences.

Classes IPC  ?

• H10B 53/30 - Dispositifs RAM ferro-électrique [FeRAM] comprenant des condensateurs ferro-électriques de mémoire caractérisés par la région noyau de mémoire
• C04B 35/40 - Produits céramiques mis en forme, caractérisés par leur compositionCompositions céramiquesTraitement de poudres de composés inorganiques préalablement à la fabrication de produits céramiques à base d'oxydes à base de ferrites avec des oxydes de terres rares
• G11C 11/22 - Mémoires numériques caractérisées par l'utilisation d'éléments d'emmagasinage électriques ou magnétiques particuliersÉléments d'emmagasinage correspondants utilisant des éléments électriques utilisant des éléments ferro-électriques

Abrégé

An image processing algorithm evaluating apparatus includes: an image storage unit that stores a plurality of actual images captured from a vehicle; an image generating unit that acquires a target image, when receiving disturbance information representing a disturbance in the target image from among the plurality of actual images stored in the image storage unit, interprets the target image, and generates a composite image by manipulating the target image in such a manner that the disturbance is reflected to the target image based on the interpretation; and an image processing unit that evaluates performance of an image processing algorithm for determining a situation around the vehicle based on the generated composite image.

Classes IPC  ?

• G06V 10/776 - ValidationÉvaluation des performances
• G06V 10/774 - Génération d'ensembles de motifs de formationTraitement des caractéristiques d’images ou de vidéos dans les espaces de caractéristiquesDispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant l’intégration et la réduction de données, p. ex. analyse en composantes principales [PCA] ou analyse en composantes indépendantes [ ICA] ou cartes auto-organisatrices [SOM]Séparation aveugle de source méthodes de Bootstrap, p. ex. "bagging” ou “boosting”
• G06V 20/56 - Contexte ou environnement de l’image à l’extérieur d’un véhicule à partir de capteurs embarqués

Abrégé

Provided is a vertical diode in which a first electrode, an organic semiconductor layer, and a second electrode are laminated adjacently in the stated order, wherein low-molecular hydrophobic ions are attached to the surface of the first electrode adjacent to the organic semiconductor layer.

Classes IPC  ?

• H10K 10/20 - Diodes organiques
• H10D 8/01 - Fabrication ou traitement
• H10D 8/50 - Diodes PIN

Abrégé

This magnetic sensor includes: a topological semimetal; a ferromagnetic body which is joined to the topological semimetal; and a measurement device for measuring a magnetic field on the basis of a voltage due to an odd-parity magnetoresistance effect generated in the topological semimetal.

Classes IPC  ?

• H10N 52/80 - Détails de structure
• G01R 33/09 - Mesure de la direction ou de l'intensité de champs magnétiques ou de flux magnétiques en utilisant des dispositifs galvano-magnétiques des dispositifs magnéto-résistifs