A method for the synthesis of alkyl ω-carboxy(hydroxyethyl) polysaccharides is described. The method includes methylating or ethylating a polysaccharide or providing a methylated or ethylated polysaccharide, hydroxyethylating the methylated or ethylated polysaccharide, and oxidizing the hydroxyethylated polysaccharide to form the ω-carboxy(hydroxyethyl) polysaccharide. A method for the synthesis of oxidized polysaccharides is also described. The method includes hydroxypropylating a polysaccharide and oxidizing the hydroxypropylated polysaccharides. A method for the production of a solid capable of forming a hydrogel is also described. The method includes combining a first solution comprising an oxidized oligo(hydroxypropyl) polysaccharide bearing one or more ketone groups with a second solution comprising an amine substituted polysaccharide to form a third solution, and removing solvent from the third solution to form the solid, or adding an additional solvent to the third solution to precipitate the solid. Novel polysaccharides and hydrogels prepared according to these methods are also described.
Power converters with integrated transformers and resonant inductors are described. An example integrated transformer can be electrically coupled between a primary-side converter stage and a secondary-side converter stage in a power converter. The integrated transformer can include a magnetic core with plurality of core legs, a primary winding extending around each of the plurality of core legs, and a secondary winding extending around each of the plurality of core legs. A winding direction of the primary winding is alternated between adjacent core legs among the plurality of core legs, and a winding direction of the secondary winding is alternated between adjacent core legs among the plurality of core legs. Additionally, a number of winding turns of the primary winding and a number of winding turns of the secondary winding on a first core leg is different than on a second core leg among the plurality of core legs.
H01F 27/30 - Fixation ou serrage de bobines, d'enroulements ou de parties de ceux-ci entre euxFixation ou montage des bobines ou enroulements sur le noyau, dans l'enveloppe ou sur un autre support
H02M 3/335 - Transformation d'une puissance d'entrée en courant continu en une puissance de sortie en courant continu avec transformation intermédiaire en courant alternatif par convertisseurs statiques utilisant des tubes à décharge avec électrode de commande ou des dispositifs à semi-conducteurs avec électrodes de commande pour produire le courant alternatif intermédiaire utilisant des dispositifs du type triode ou transistor exigeant l'application continue d'un signal de commande utilisant uniquement des dispositifs à semi-conducteurs
Various examples are provided related to a sensor (e.g., biosensor) for selective ion-detection in a sample. In one example, a potentiometric sensor includes a base; a working electrode (WE) set into the base; and a reference electrode (RE) set into the base adjacent to the working electrode. The working electrode includes a WE well filled with a WE solid-state material and the reference electrode includes a RE well, adjacent to the WE well, filled with a RE solid-state material. An example of a method for measuring a concentration of ions in a sample using the potentiometric sensor includes obtaining a biological sample; bringing the biological sample into contact with both the WE well and the RE well; and measuring the open circuit potential between the working electrode and the reference electrode. Also disclosed is a system comprising the disclosed sensor and a microfluidic device in fluid communication with the sensor.
G01N 27/27 - Association de plusieurs systèmes ou cellules de mesure, chacun mesurant un paramètre différent, dans laquelle les résultats des mesures peuvent être, soit utilisès indépendamment, les systèmes ou les cellules étant physiquement associés, soit combinés pour produire une valeur représentative d'un autre paramètre
5.
HYBRID DEVICE AND NETWORK ENTITY FOR A WIRELESS SYSTEM
The present disclosure is directed to a Hybrid Device and Network (HDN) entity for a wireless system. One general aspect includes an HDN entity that includes a processing unit configured to perform functions conventionally associated with a user equipment and to execute scheduling functions conventionally associated with a base station, where the scheduling functions may include allocating radio resources to one or more communication devices within a target coverage area of the HDN entity. The HDN entity also includes a control channel interface operably coupled to the processing unit. The control channel interface is configured to transmit and receive control signals used for managing the allocated radio resources for the one or more communication devices.
Embodiments of interplanar interconnects, intraplanar interconnects, and methods for forming the same in rigid, flexible, and stretchable substrates are described. In one example, a method for forming interplanar interconnects in a substrate includes injecting a solution into a mold cavity of a molding structure. The solution includes a polymer matrix and liquid metal elements. The method further includes performing a curing process on the solution to form an interplanar interconnect in the polymer matrix. The curing process includes exposing different regions of the solution to light while the molding structure is positioned in different orientations to cause selective sedimentation of the liquid metal elements in the solution.
Embodiments of a liquid metal paste for coupling conductive components of circuits formed in or on rigid, flexible, and stretchable substrates are described. In one example, a liquid metal paste includes liquid metal. The liquid metal paste further includes copper elements mixed with the liquid metal to form a conductive mixture. In another example, the liquid metal paste further includes an elastomer material mixed with the liquid metal to form a conductive and adhesive mixture.
Various embodiments of a system and method for a smart work zone are described. In one example, the system includes smart cone devices configured to transmit smart cone device localization data, a wearable device comprising a processor configured to transmit worker localization data of a worker wearing the garment device and to receive an alert, and a base station. The base station includes an internal edge computing system configured to process the smart cone device localization data to define a virtual geofence boundary of a safe area, process the worker localization data, broadcast a location of the worker wearing the wearable device, and in response to a vehicle or the worker approaching the virtual geofence boundary, provide an alert to at least one of: the worker wearing the wearable device, a passing motorist, or a connected and automated vehicle (CAV).
G08B 7/06 - Systèmes de signalisation selon plus d'un des groupes Systèmes d'appel de personnes selon plus d'un des groupes utilisant une transmission électrique
G08B 21/02 - Alarmes pour assurer la sécurité des personnes
G08B 25/00 - Systèmes d'alarme dans lesquels l'emplacement du lieu où existe la condition déclenchant l'alarme est signalé à une station centrale, p. ex. systèmes télégraphiques d'incendie ou de police
G08B 25/01 - Systèmes d'alarme dans lesquels l'emplacement du lieu où existe la condition déclenchant l'alarme est signalé à une station centrale, p. ex. systèmes télégraphiques d'incendie ou de police caractérisés par le moyen de transmission
G08B 25/10 - Systèmes d'alarme dans lesquels l'emplacement du lieu où existe la condition déclenchant l'alarme est signalé à une station centrale, p. ex. systèmes télégraphiques d'incendie ou de police caractérisés par le moyen de transmission utilisant des systèmes de transmission sans fil
G08B 31/00 - Systèmes d'alarme à prédiction caractérisés par une extrapolation ou un autre type de calcul utilisant des données historiques mises à jour
H04W 4/02 - Services utilisant des informations de localisation
H04W 4/021 - Services concernant des domaines particuliers, p. ex. services de points d’intérêt, services sur place ou géorepères
H04W 4/44 - Services spécialement adaptés à des environnements, à des situations ou à des fins spécifiques pour les véhicules, p. ex. communication véhicule-piétons pour la communication entre véhicules et infrastructures, p. ex. véhicule à nuage ou véhicule à domicile
H04W 4/90 - Services pour gérer les situations d’urgence ou dangereuses, p. ex. systèmes d’alerte aux séismes et aux tsunamis
Disclosed are embodiments for a multi-device power consumption optimization framework that can conserve total power consumed across a collection of computing devices. In one embodiment, a method can include: obtaining power consumption characteristics data corresponding respectively to each of a plurality of computing devices associated with a user; generating a collective power saving strategy corresponding to the plurality of computing devices based on the power consumption characteristics data, the collective power saving strategy comprising one or more power saving operations that, when implemented, conserve a total amount of power used by the plurality of computing devices; and instructing one or more computing devices of the plurality of computing devices to perform at least one of the one or more power saving operations based on the user approval data.
Power converters with integrated controllable coupling inductors are described. An example power converter includes a number of converter stages and an integrated coupled inductor. The integrated coupled inductor includes a magnetic core having a first side leg, a first leg, a center leg, a second leg, and a second side leg. The integrated coupled inductor also includes a first and second windings for first and second converter stage among the converter stages. The first winding extends around the first leg, and the second winding extends around the second leg of the magnetic core. The integrated coupled inductor can also include a second magnetic core with third and fourth windings for additional converter stages and a coupling winding extending around center legs of the magnetic core and the second magnetic core. The integrated coupled inductor does not include a coupling inductor separate from the magnetic core and the second magnetic core.
H02M 1/00 - Détails d'appareils pour transformation
H01F 27/30 - Fixation ou serrage de bobines, d'enroulements ou de parties de ceux-ci entre euxFixation ou montage des bobines ou enroulements sur le noyau, dans l'enveloppe ou sur un autre support
H01F 27/38 - Organes de noyaux auxiliairesBobines ou enroulements auxiliaires
H02M 3/158 - Transformation d'une puissance d'entrée en courant continu en une puissance de sortie en courant continu sans transformation intermédiaire en courant alternatif par convertisseurs statiques utilisant des tubes à décharge avec électrode de commande ou des dispositifs à semi-conducteurs avec électrode de commande utilisant des dispositifs du type triode ou transistor exigeant l'application continue d'un signal de commande utilisant uniquement des dispositifs à semi-conducteurs avec commande automatique de la tension ou du courant de sortie, p. ex. régulateurs à commutation comprenant plusieurs dispositifs à semi-conducteurs comme dispositifs de commande finale pour une charge unique
11.
Learning approximate estimation networks for communication channel state information
Methods, systems, and apparatus, including computer programs encoded on computer storage media, for training and deploying machine-learning estimation networks in a communications system. One of the methods includes: processing first information with ground truth information to generate a first RF signal by altering the first information by channel impairment having at least one channel effect, using a receiver to process the first RF signal to generate second information, training a machine-learning estimation network based on a network architecture, the second information, and the ground truth information, receiving by the receiver a second RF signal transmitted through a communication channel including the at least one channel effect, inferring by the trained estimation network the receiver to estimate an offset of the second RF signal caused by the at least one channel effect, and correcting the offset of the RF signal with the estimated offset to obtain a recovered RF signal.
In one aspect, the disclosure relates to a variety of crystalline materials that have a 2D crystal structure and an in-plane anisotropy. The crystalline materials can include metals having a partially filled d shell and that undergo a Jahn-Teller distortion. The crystalline materials can include incorporating two organic spacers in the same repeating layers to induced additional out-of-plane heterogeneity. The crystalline materials can exhibit broad wavelength optical retardation. The materials can be used in lenses such as in an achromatic quarter waveplate (A-QWP).
Described in several exemplary embodiments herein are serum replacement compositions, cell culture media containing said serum replacement compositions, and uses thereof.
C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p. ex. lignées cellulairesTissusLeur culture ou conservationMilieux de culture à cet effet
C07K 14/39 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de champignons provenant de levures
C07K 14/405 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'algues
C07K 14/415 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de végétaux
C07K 14/435 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
C12N 9/54 - Protéinases provenant de bactéries les bactéries étant du genre Bacillus
14.
LEARNING RADIO SIGNALS USING RADIO SIGNAL TRANSFORMERS
Methods, systems, and apparatus, including computer programs encoded on a storage medium, for processing radio signals. In once aspect, a system is disclosed that includes a processor and a storage device storing computer code that includes operations. The operations may include obtaining first output data generated by a first neural network based on the first neural network processing a received radio signal, receiving, by a signal transformer, a second set of input data that includes (i) the received radio signal and (ii) the first output data, generating, by the signal transformer, data representing a transformed radio signal by applying one or more transforms to the received radio signal, providing the data representing the transformed radio signal to a second neural network, obtaining second output data generated by the second neural network, and determining based on the second output data a set of information describing the received radio signal.
H04B 1/00 - Détails des systèmes de transmission, non couverts par l'un des groupes Détails des systèmes de transmission non caractérisés par le milieu utilisé pour la transmission
H04B 17/309 - Mesure ou estimation des paramètres de qualité d’un canal
Power converters with integrated transformers and resonant inductors are described. An example power converter includes a primary-side converter stage, a number of secondary-side converter stages, and an integrated transformer and resonant inductor coupled between the primary-side and secondary-side converter stages. The integrated transformer includes a magnetic core having a first leg, an auxiliary leg, and a second leg. The integrated transformer also includes a first transformer having a first primary winding, a first secondary winding, and a first shield winding on the first leg, and a second transformer having a second primary winding, a second secondary winding, and a second shield winding on the second leg. The first shield winding is electrically coupled to provide an extension of the first primary winding for the first transformer, and an end of the first shield winding or the second shield winding is electrically coupled to a primary-side ground of the power converter.
H01F 27/26 - Fixation des parties du noyau entre ellesFixation ou montage du noyau dans l'enveloppe ou sur un support
H02M 1/00 - Détails d'appareils pour transformation
H02M 3/335 - Transformation d'une puissance d'entrée en courant continu en une puissance de sortie en courant continu avec transformation intermédiaire en courant alternatif par convertisseurs statiques utilisant des tubes à décharge avec électrode de commande ou des dispositifs à semi-conducteurs avec électrodes de commande pour produire le courant alternatif intermédiaire utilisant des dispositifs du type triode ou transistor exigeant l'application continue d'un signal de commande utilisant uniquement des dispositifs à semi-conducteurs
16.
TRAPEZOIDAL CURRENT CONTROL IN ELECTRONIC TRANSFORMERS
Power converters including electronic-embedded transformers for current sharing and load-independent voltage gain are described. An example power converter system includes an input, an output, a power converter between the input and output, and a controller. The converter includes a first bridge, a second bridge, and an electronic-embedded transformer (EET) between the first and second bridge. The EET includes a capacitor and a capacitance coupling switch bridge. The controller generates phasing drive control signals for trapezoidal current modulation control of the capacitance coupling switch bridge of the EET. The controller is configured to generate the phasing drive control signals based on a phase shift coefficient, k, to set a duty cycle of a voltage from the capacitance coupling switch bridge. The controller is also configured to vary k from between 0 to 0.5 based on a load applied to the power converter system or other operating aspects of the power converter.
H02M 3/335 - Transformation d'une puissance d'entrée en courant continu en une puissance de sortie en courant continu avec transformation intermédiaire en courant alternatif par convertisseurs statiques utilisant des tubes à décharge avec électrode de commande ou des dispositifs à semi-conducteurs avec électrodes de commande pour produire le courant alternatif intermédiaire utilisant des dispositifs du type triode ou transistor exigeant l'application continue d'un signal de commande utilisant uniquement des dispositifs à semi-conducteurs
H02M 1/00 - Détails d'appareils pour transformation
17.
RESONANT COMMUTATION AND QUASI-TRAPEZOIDAL CURRENT CONTROL IN ELECTRONIC TRANSFORMERS
Power converters including electronic-embedded transformers for current sharing and load-independent voltage gain are described. An example power converter system includes an input, an output, a power converter between the input and output, and a controller. The converter includes a first bridge, a second bridge, and an electronic-embedded transformer between the first and second bridge. The electronic-embedded transformer includes a bidirectional coupling switch bridge. The controller generates drive control signals for quasi-trapezoidal current modulation control of the bidirectional coupling switch bridge. The controller is configured to generate the drive control signals based on a commutation coefficient k and a switching frequency for the power converter. The commutation coefficient k can be set based on an inductance in the electronic-embedded transformer, a capacitance in the bidirectional coupling switch bridge, and a margin for resonant current commutation.
H02M 1/08 - Circuits spécialement adaptés à la production d'une tension de commande pour les dispositifs à semi-conducteurs incorporés dans des convertisseurs statiques
H02M 3/00 - Transformation d'une puissance d'entrée en courant continu en une puissance de sortie en courant continu
H02M 3/335 - Transformation d'une puissance d'entrée en courant continu en une puissance de sortie en courant continu avec transformation intermédiaire en courant alternatif par convertisseurs statiques utilisant des tubes à décharge avec électrode de commande ou des dispositifs à semi-conducteurs avec électrodes de commande pour produire le courant alternatif intermédiaire utilisant des dispositifs du type triode ou transistor exigeant l'application continue d'un signal de commande utilisant uniquement des dispositifs à semi-conducteurs
18.
DEEP LEARNING FOR SOUND SPEED IMAGING USING PULSE-ECHO ULTRASOUND
Provided are methods of creating a trained deep neural network, in embodiments the methods comprising: providing a number of natural images; converting each natural image into a speed of sound (SoS) map; for each of the SoS maps, deriving a theoretical time-shift map; and training a deep neural network based on time-shift and SoS map pairs, each of the pairs comprising one of the theoretical time-shift maps and its corresponding SoS map; wherein the deep neural network is capable of reconstructing a speed of sound (SoS) image from a measured time-shift map generated from ultrasound.
G06V 10/82 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant les réseaux neuronaux
Embodiments of a device and methodology for measuring friction coefficients of different irregularly shaped objects against different materials are described. One example device includes a sub-frame slidably coupled to a frame. The device further includes an object mount coupled to the sub-frame, a sliding surface under the object mount, and an instrumented sled on the sliding surface. The instrumented sled includes a support platform to support a material sample under the object mount. The device further includes a tension loadcell coupled to the instrumented sled and a tension load application coupled to the tension loadcell. The instrumented sled is configured to measure a normal force applied to the material sample by an irregularly shaped object coupled to the object mount during operation of the device. The tension load application is operable to apply a tangential force to the instrumented sled. The tension loadcell is operable to measure the tangential force.
G01L 5/00 - Appareils ou procédés pour la mesure des forces, du travail, de la puissance mécanique ou du couple, spécialement adaptés à des fins spécifiques
Disclosed are various embodiments for scattering array interferometers. In one embodiment, an optical medium comprises one or more scattering array interferometers in the optical medium. Each of the scattering array interferometers includes a respective array or other spatial distribution of scatterers/reflectors comprising at least two scatterers/reflectors that are uniformly sized and spaced according to a corresponding pitch. The respective array or other spatial distribution of scatterers/reflectors is configured to cause coherent light interference when a light source is applied to the optical medium.
G01N 21/45 - RéfringencePropriétés liées à la phase, p. ex. longueur du chemin optique en utilisant des méthodes interférométriquesRéfringencePropriétés liées à la phase, p. ex. longueur du chemin optique en utilisant les méthodes de Schlieren
21.
METHODS FOR PREVENTING OR REDUCING BACTERIAL INFECTION OF PLANT SEEDS
Described herein are methods preventing or reducing a bacterial infection on a plant seed. In one aspect, the method involves applying to the plant seed epigallocatechin-3 gallate, catechin, epicatechin, or any combination thereof. In one aspect, a mixture comprising epigallocatechin-3 gallate, catechin, and epicatechin is applied to the plant seed. In another aspect, green tea is applied to the plant seed. In other aspects, epigallocatechin-3 gallate, catechin, epicatechin, or any combination thereof is applied to plant seed in combination with an antibiotic, where a synergistic effect is observed. In other aspects, epigallocatechin-3 gallate, catechin, epicatechin, or any combination thereof is added to soil before and/or after the seed is planted in the soil.
A01N 43/16 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés hétérocycliques comportant des cycles avec un ou plusieurs atomes d'oxygène ou de soufre comme uniques hétéro-atomes du cycle avec un hétéro-atome des cycles à six chaînons avec l'oxygène comme hétéro-atome du cycle
A01N 43/40 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés hétérocycliques comportant des cycles avec un atome d'azote comme unique hétéro-atome du cycle des cycles à six chaînons
A01N 43/90 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés hétérocycliques comportant plusieurs hétérocycles déterminants condensés entre eux ou avec un système carbocyclique commun
Aspects of transcranial magnetic stimulation (TMS) devices are described. In one example, the TMS device includes a magnetic flux shutter that includes a multi-turn coil and a magnetic film. The magnetic film extends in a loop to encircle a region, and the multi-turn coil is continuously wound around the magnetic film. The TMS device also includes a magnet that is positioned in the region within a boundary of the magnetic film, with the magnet generating a magnetic flux. The TMS device also includes a current source coupled to the multi-turn coil. The current source is configured to deliver a current to the multi-turn coil, to vary a permeability of the magnetic film and a density of the magnetic flux extending outside the region of the magnetic flux shutter during operation.
A61N 2/02 - Magnétothérapie utilisant des champs magnétiques produits par des bobines, y compris par des boucles à spire unique ou par des électro-aimants
Disclosed herein are methods and systems for creating educational virtual reality environments. One or more cameras may capture 360-degree images of a medical environment. Each of the 360-degree images are captured with a camera being placed at a respective location. A computing device may create a virtual reality environment of the medical environment based on the 360-degree images, by, for each of the 360-degree images, placing a user viewpoint at the respective location of the respective camera that captured the respective 360-degree image, placing a graphical representation of a first class at each other respective location that is visible in the respective 360-degree image, and placing a graphical representation of a second class over each object visible in the respective 360-degree image that has particular educational content assigned to the object. The computing device may output, for interactive display at a virtual reality device, the virtual reality environment.
Methods of extracting rare earth elements (REEs) from low-grade REE sources composed of clayey materials. In one aspect, the REE sources are the waste materials generated in the coal and kaolin clay industries during the courses of upgrading mined coal and kaolinite. The methods described herein include the steps of pre-concentrating REE-bearing minerals using physical separation methods to prepare high-grade feedstocks for the chemical extraction of high-value REEs and critical materials while minimizing both the capital and operating costs.
C22B 59/00 - Obtention des métaux des terres rares
C22B 1/11 - Élimination du soufre, du phosphore ou de l'arsenic autrement que par grillage
C22B 3/14 - Extraction de composés métalliques par voie humide à partir de minerais ou de concentrés par lixiviation dans des solutions inorganiques alcalines contenant de l'ammoniaque ou des sels d'ammonium
C22B 3/18 - Extraction de composés métalliques par voie humide à partir de minerais ou de concentrés à l'aide de micro-organismes ou d'enzymes, p. ex. de bactéries ou d'algues
Described in certain example embodiments herein are engineered phages comprising one or more heterologous genes that encode one or more heterologous gene products and methods of using the engineered phages to deliver one or more heterologous gene products to a subject.
The present disclosure provides genetically modified microbes. A genetically modified microbe includes a lysogenic P22 phage and at least one exogenous coding region. The exogenous coding region can encode a Salmonella modification system methylase, a C2 protein, a C2-inhibiting protein, rfb gene cluster coding regions and a rfc coding region, or a combination thereof. Also provided are compositions that include the genetically modified microbe and methods of using the genetically modified microbe.
Metamaterial adhesives and metamaterial adhesive systems are described. The metamaterial adhesive systems simultaneously achieve strong and releasable adhesion with spatially selectable adhesion strength through programmed cut architectures. The programmed cut architectures define flap and interconnect regions on a metamaterial adhesive film or a substrate having the metamaterial adhesive film deposited on at least one side of the substrate, among other examples. An example metamaterial adhesive system includes a flexible strip having multiple flaps formed on the flexible strip and a metamaterial adhesive or film deposited on at least one side of one or more of the multiple flaps.
B32B 3/26 - Produits stratifiés comprenant une couche ayant des discontinuités ou des rugosités externes ou internes, ou une couche de forme non planeProduits stratifiés comprenant une couche ayant des particularités au niveau de sa forme caractérisés par une couche continue dont le périmètre de la section droite a une allure particulièreProduits stratifiés comprenant une couche ayant des discontinuités ou des rugosités externes ou internes, ou une couche de forme non planeProduits stratifiés comprenant une couche ayant des particularités au niveau de sa forme caractérisés par une couche comportant des cavités ou des vides internes
B32B 7/06 - Liaison entre couches permettant une séparation sans difficultés
B32B 25/08 - Produits stratifiés composés essentiellement de caoutchouc naturel ou synthétique comprenant du caoutchouc comme seul composant ou comme composant principal d'une couche adjacente à une autre couche d'une substance spécifique de résine synthétique
B32B 25/20 - Produits stratifiés composés essentiellement de caoutchouc naturel ou synthétique comprenant du caoutchouc au silicone
28.
HUMAN POWERED SOFT ROBOTICS FOR NEUROMUSCULAR DISORDERS
An apparatus may include at least one sensor bladder for positioning in relation to the foot of a user. An apparatus may also include at least one stimulation bladder corresponding to the respective at least one sensor bladder, the at least one stimulation bladder positioned on the body of the user remotely from the foot. An apparatus may include at least one conduit fluidly coupling the respective at least one sensor bladder with the respective at least one stimulation bladder, where the at least one sensor bladder is configured to compress responsive to movement of the foot of the user and drive fluid from the at least one sensor bladder to the respective at least one stimulation bladder via the respective at least one conduit.
29.
CASCADE DEGRADATION AND UPCYCLING OF POLYSTYRENE WASTE TO HIGH VALUE CHEMICALS
C08J 11/20 - Récupération ou traitement des résidus des polymères par coupure des chaînes moléculaires des polymères ou rupture des liaisons de réticulation par voie chimique, p. ex. dévulcanisation par traitement avec une substance organique par traitement avec des hydrocarbures ou des hydrocarbures halogénés
C08J 3/205 - Formation de mélanges de polymères avec des additifs, p. ex. coloration en présence d'une phase liquide
Methods and systems of single-cell bisulfite sequencing are provided. The single-cell bisulfite sequencing techniques of the disclosure involve single-cell DNA (scDNA) droplets, where the scDNA are fragmented within the scDNA droplets prior to bisulfite conversion. The methods and systems further include barcode droplets, and fusing the scDNA droplets with the barcode droplets to form barcoded scDNA droplets for bisulfite conversion. The bisulfite conversion beneficially occurs within the bisulfite droplets to reduce DNA degradation. The single-cell bisulfite sequencing method and systems provide for bisulfite sequenced nucleic acid libraries.
Embodiments of lower body exoskeletons having linear actuators are described. In one example, an exoskeleton includes an upper juncture assembly for positioning at least partly around a waist of a user. The exoskeleton further includes a linear actuator having a first end and a second end opposite the first end. The first end of the linear actuator is coupled to the upper juncture assembly. The exoskeleton further includes a lower juncture assembly coupled to the second end of the linear actuator. The lower juncture assembly is configured for positioning the second end of the linear actuator at a side of a foot of the user. The exoskeleton further includes a foot attachment interface for positioning at least partly around the foot of the user.
Degraded electrode material from a used battery can be recycled by subjecting to a thermal shock. The degraded electrode material can have impurities resulting from charge/discharge cycling of the battery. The thermal shock can have a temperature of at least 1000 K for a time period of 10 seconds or less, for example, less than or equal to 1 second. The thermal shock can also include a heating rate of at least 103 K/second preceding the time period and a cooling rate of at least 103 K/second following the time period. The subjecting to the thermal shock regenerate the electrode material, for example, by removing impurities from the electrode material and/or replenishing metal ions within the electrode material.
B09B 3/40 - Destruction de déchets solides ou transformation de déchets solides en quelque chose d'utile ou d'inoffensif impliquant un traitement thermique, p. ex. évaporation
Concepts directed to multi-modal bio-interfacing devices and methods for fabricating and implementing the same are described. In one example, a device for bio-interfacing applications includes a multi-modal bio-interfacing structure formed on a substrate. The multi-modal bio-interfacing structure includes a microelectrode pad formed on the substrate and a micropillar electrode extending from the microelectrode pad. The multi-modal bio-interfacing structure further includes a plurality of nanoantennas formed on the micropillar electrode.
B82Y 15/00 - Nanotechnologie pour l’interaction, la détection ou l'actionnement, p. ex. points quantiques comme marqueurs en dosages protéiques ou moteurs moléculaires
35.
B. BURGDORFERI PEPTIDOGLYCAN ANTIBODIES AND USES THEREOF
Described herein are compositions, assays, techniques, methods, for treating and/or detecting a Borrelia burgdorferi microorganism, the causative agent of Lyme disease.
In various aspects and embodiments provided are compositions containing extracellular vesicles (including modified extracellular vesicles), methods of making preparations of extracellular vesicles, methods of modifying extracellular vesicles and methods of using modified and/or unmodified extracellular vesicles.
A61K 9/127 - Vecteurs à bicouches synthétiques, p. ex. liposomes ou liposomes comportant du cholestérol en tant qu’unique agent tensioactif non phosphatidylique
C12N 15/85 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules animales
C12N 15/88 - Introduction de matériel génétique étranger utilisant des procédés non prévus ailleurs, p. ex. co-transformation utilisant la micro-encapsulation, p. ex. utilisant des vésicules liposomiques
B82Y 5/00 - Nanobiotechnologie ou nanomédecine, p. ex. génie protéique ou administration de médicaments
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
Multi-modal fiber probe devices and processes for fabricating the same are described. In one example, a multi-modal fiber probe device can include a flexible tapered fiber probe structure having a micro-scale tip region at a first end and a macro-scale connector region at a second end opposite the first end. The multi-modal fiber probe device can further include an optical waveguide positioned in and extending through the flexible tapered fiber probe structure from the micro-scale tip region to the macro-scale connector region. The multi-modal fiber probe device can further include a microfluidic channel formed in and extending through the flexible tapered fiber probe structure from the micro-scale tip region to the macro-scale connector region.
A61N 5/06 - Thérapie par radiations utilisant un rayonnement lumineux
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
Various examples are provided in relation to improved recovery and throughput of both fine and coarse particulate materials. In one example, a method includes injecting an aqueous suspension of a cloud of small air bubbles into an aqueous phase including fine particulate materials, wherein the fine particulate material is selectively hydrophobized and collected by small air bubbles; allowing the bubbles to rise in the aqueous phase; and collecting the air bubbles to obtain a concentrate of the fine particulate materials. In another example, a method includes adding a hydrophobizing agent to an aqueous phase to render coarse particulate material selectively hydrophobic; allowing air bubbles to attach to the coarse particulate material and changing the apparent specific gravity of the coarse particulate materials so a layer of one type of coarse particle is formed on top; allowing the one type of coarse particles to float and enter the forth phase.
C22B 3/22 - Traitement ou purification de solutions, p. ex. de solutions obtenues par lixiviation par des procédés physiques, p. ex. par filtration, par des moyens magnétiques
Described herein are methods for methods for extracting earth elements from rare earth element sources. In one aspect, the rare earth element source includes clayey materials present in coal and coal by-products, where one or more rare earth elements are adsorbed on the clayey materials. The methods involve admixing the rare earth element source with a base and an electrolyte composition. In one aspect, the electrolyte composition includes a chelating agent and/or a complexing agent. The extraction process is conducted at temperatures less than or equal to 100° C., which makes the process cost-effective and sustainable.
C22B 3/12 - Extraction de composés métalliques par voie humide à partir de minerais ou de concentrés par lixiviation dans des solutions inorganiques alcalines
C22B 3/22 - Traitement ou purification de solutions, p. ex. de solutions obtenues par lixiviation par des procédés physiques, p. ex. par filtration, par des moyens magnétiques
C22B 3/42 - Traitement ou purification de solutions, p. ex. de solutions obtenues par lixiviation par extraction utilisant l'échange d'ions
40.
UPCYCLING OF POLYETHYLENE AND POLYPROPYLENE AND THEIR MIXTURES TO HIGH-VALUE SURFACTANTS
Herein, a method for controlling the thermolysis products molar mass using a coolant fluid (e.g., water) to modulate the final products' condensation temperatures. With this strategy, the thermolysis of polyethylene (PE) and polypropylene (PP) is tailored to generate liquid oil, without any catalysts or additives. Subsequent addition of sulfuric acid across the alkenyl groups, followed by the neutralization with sodium hydroxide affords sulfate detergents with excellent foaming behavior.
C11C 3/00 - Graisses, huiles ou acides gras obtenus par transformation chimique des graisses, huiles ou acides gras, p. ex. ozonolyse
C07C 4/02 - Préparations d'hydrocarbures à partir d'hydrocarbures contenant un plus grand nombre d'atomes de carbone par craquage d'un hydrocarbure unique ou d'un mélange d'hydrocarbures individuellement définis ou d'une fraction d'hydrocarbures normalement gazeux
C10G 1/10 - Production de mélanges liquides d'hydrocarbures à partir de schiste bitumineux, de sable pétrolifère ou de matières carbonées solides non fusibles ou similaires, p. ex. bois, charbon à partir de caoutchouc ou de déchets de caoutchouc
41.
SYSTEMS AND METHODS FOR PROTECTING BYSTANDER VISUAL DATA IN AUGMENTED REALITY SYSTEMS
Embodiments of the present disclosure introduce approaches for protecting bystander privacy in a wearable augmented reality (AR) device. In one embodiment, a video frame is captured via a camera of the wearable AR device, and faces are detected in the video frame. A first face is classified as a subject based at least in part on eye gaze tracking of a user of the wearable AR device by an eye gaze sensor of the wearable AR device. A second face is classified as a bystander based at least in part on the eye gaze tracking of the user. The second face is obscured in the video frame in response to the second face being classified as the bystander.
G06T 7/70 - Détermination de la position ou de l'orientation des objets ou des caméras
G06V 10/22 - Prétraitement de l’image par la sélection d’une région spécifique contenant ou référençant une formeLocalisation ou traitement de régions spécifiques visant à guider la détection ou la reconnaissance
G06V 40/16 - Visages humains, p. ex. parties du visage, croquis ou expressions
A61B 3/113 - Appareils pour l'examen optique des yeuxAppareils pour l'examen clinique des yeux du type à mesure objective, c.-à-d. instruments pour l'examen des yeux indépendamment des perceptions ou des réactions du patient pour déterminer ou enregistrer le mouvement de l'œil
G10L 25/51 - Techniques d'analyse de la parole ou de la voix qui ne se limitent pas à un seul des groupes spécialement adaptées pour un usage particulier pour comparaison ou différentiation
H04W 12/63 - Sécurité dépendant du contexte dépendant de la localisationSécurité dépendant du contexte dépendant de la proximité
42.
INHIBITORS OF SPINSTER HOMOLOG 2 (SPNS2) FOR USE IN THERAPY
The present disclosure provides SPNS2 inhibitor compounds according to Formula I: where T, U, V, W, X, R1, R2, and m are defined herein. The present disclosure also provides pharmaceutically acceptable salts, and/or tautomers of Formula I compounds as described in the disclosure. Also provided are their methods of use in therapy, such as in diseases for which immunomodulation and/or anti-fibrotic activity is indicated.
C07D 213/65 - Un atome d'oxygène lié en position 3 ou 5
C07D 235/16 - Radicaux substitués par des atomes de carbone comportant trois liaisons à des hétéro-atomes, avec au plus une liaison à un halogène, p. ex. radicaux ester ou nitrile
C07D 413/12 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes d'azote et d'oxygène comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
Various examples are provided related to nanofiber networks that can mimic in vivo physiology. In one example, a scaffold includes a nanofiber membrane extending across a scaffold opening. The nanofiber membrane can include a stack of nanofiber layers that include nanofibers disposed with a controlled orientation or direction and a controlled spacing. The nanofibers are cross-linked with nanofibers of an adjacent nanofiber layer. The scaffold can be incorporated into a transwell insert or plate. In another example, a microfluidic chip can include a first channel layer with a first fluid channel; a second channel layer comprising a second fluid channel; and a scaffold including a nanofiber membrane disposed between the first and second channel layers. The first and second channels cross each other.
C12M 1/12 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens de stérilisation, filtration ou dialyse
C12M 3/06 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus avec des moyens de filtration, d'ultrafiltration, d'osmose inverse ou de dialyse
44.
PLANAR TRANSFORMER WITH FLEXIBLE TURN RATIO AND LEAKAGE INDUCTANCE INTEGRATION
An example power converter may include a planar transformer including a magnetic core, a primary winding, a first secondary winding interleaved with the primary winding, and a second secondary winding interleaved with the primary winding. The magnetic core may include a first core half, a second core half, multiple auxiliary legs formed by the first core half and the second core half, and multiple core legs formed by the first core half and the second core half. The multiple core legs may include a central core leg, and the primary winding may be wound around the central core leg among the two or more core legs. The planar transformer may be electrically coupled between a primary-side converter stage and a secondary-side converter stage.
H01F 27/38 - Organes de noyaux auxiliairesBobines ou enroulements auxiliaires
H02M 3/335 - Transformation d'une puissance d'entrée en courant continu en une puissance de sortie en courant continu avec transformation intermédiaire en courant alternatif par convertisseurs statiques utilisant des tubes à décharge avec électrode de commande ou des dispositifs à semi-conducteurs avec électrodes de commande pour produire le courant alternatif intermédiaire utilisant des dispositifs du type triode ou transistor exigeant l'application continue d'un signal de commande utilisant uniquement des dispositifs à semi-conducteurs
45.
RECHARGEABLE SOLID STATE LITHIUM BATTERIES WORKING OVER A WIDE TEMPERATURE RANGE
Composite electrolytes are provided that are useful as a solid-state electrolyte in alkali metal batteries. in particular in lithium metal batteries over a wide temperature range. In some aspects. the composite electrolyte includes an alkali metal salt of an aromatic polyimide polymer: and an ionic liquid: wherein the composite is a solid at 25° C. and at a temperature of about 200° C. For example. a molecular ionic composite electrolyte containing 10 wt % PBDT and 90 wt % 1-ethyl-3-methylimidazolium trifluoromethane-sulfonate (EMImTfO) shows an E′ of ≈0.4 GPa and an ionic conductivity of ≈ 3.2 mS cm− at room temperature. In various aspects. batteries are also provided containing a composite electrolyte described herein. The electrolytes enable batteries that are more stable and exhibit less risk of fire or thermal runaway, even when operated at elevated temperatures. In some instances. the alkali metal is lithium and the alkali metal anode is a lithium anode.
H01M 10/0565 - Matériaux polymères, p. ex. du type gel ou du type solide
H01M 10/0525 - Batteries du type "rocking chair" ou "fauteuil à bascule", p. ex. batteries à insertion ou intercalation de lithium dans les deux électrodesBatteries à l'ion lithium
46.
SECURITY SIGNATURES IN BINDING AGENT JETTING PARTS
Embodiments are described for forming regions of varying porosity within an additive manufacturing (AM) object through selective deposition of a binding agent during fabrication. Upon sintering, the selectively applied binding agent forms stochastic regions of porosity within the object that are not externally visible. In some implementations, embedded porous regions are selectively generated to form an identifier region that can be used as a unique part identification tag identifiable through non-destructive evaluation. The identifier tag may be useful in anti-counterfeiting security for parts fabricated through binding agent jetting (BT) and other additive manufacturing techniques.
Perception quality assessment concepts for an object detection system are described. An example method can include identifying true positive and/or false negative object detection data in object detection data generated by an object detection system based on an image. The method can also include generating a saliency map based on the image. The saliency map can include saliency intensity data corresponding to the image. The method can also include identifying true positive and/or false negative saliency intensity data in the saliency map based on the true positive and/or false negative object detection data, respectively. The method can also include calculating a perception quality metric (PQM) based on the true positive and/or false negative saliency intensity data. The PQM can be indicative of a degree of perception quality of the object detection system with respect to the image. The method can also include performing an operation based on the PQM.
G06V 10/70 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique
G06V 10/25 - Détermination d’une région d’intérêt [ROI] ou d’un volume d’intérêt [VOI]
G06V 20/58 - Reconnaissance d’objets en mouvement ou d’obstacles, p. ex. véhicules ou piétonsReconnaissance des objets de la circulation, p. ex. signalisation routière, feux de signalisation ou routes
An example feedback control system includes a laser powder bed fusion (L-PBF) platform including a laser. The L-BPF platform is configured to print a target object with the laser. The feedback control system includes a sensing system configured to measure an operative thermal emission index (TEI) emitted during print of the target object by the L-PBF platform. The feedback control system additionally includes a controller communicatively coupled to the sensing system. The feedback control signal is configured to determine an error based on a comparison between a control setpoint and the operative TEI, generate a control signal based on the error, and adaptively adjust a power of the laser during the print of the target object based on the control signal to maintain the control setpoint.
Methods and systems for distributing electrical energy to tissue which minimize Joule heating, thermal effects, and/or thermal damage, without sacrificing efficacy of treatment, are described. The methods and systems are particularly suitable to electrical energy-based therapies employing multiple electrodes, such as arrays of electrodes.
A61B 18/12 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par chauffage en faisant passer des courants à travers les tissus à chauffer, p. ex. des courants à haute fréquence
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux
A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures
A61N 1/32 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents
Various embodiments of a smart non-pneumatic tire and methods for generating a mean vibration characteristic of the smart non-pneumatic tire are described. In one embodiment, a method for measuring the mean vibration characteristic includes receiving tire-road contact acceleration data from an accelerometer that is secured near a tire-surface contact region, where the tire-road contact acceleration data includes data captured by the accelerometer over a duration of time while a tread along an outer periphery of a sector of the tire contacts a surface. The method further includes receiving velocity data for the tire and load data for the tire over the duration of time. The method further includes generating a mean vibration characteristic based on the above-mentioned data. The method also includes changing a stiffness of spokes of the tire based on the generated mean vibration characteristic in some cases.
In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, the disclosure, in one aspect, relates to methods of additive manufacture of emulsion compositions. In various aspects, the present disclosure relates to composite materials incorporating microstructures formed by inclusion compositions, and methods of their manufacture. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
B29C 64/118 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux utilisant un matériau filamentaire mis en fusion, p. ex. modélisation par dépôt de fil en fusion [FDM]
B29K 21/00 - Utilisation de caoutchouc non spécifié ou élastomères non spécifiés comme matière de moulage
B29K 75/00 - Utilisation de polyurées ou de polyuréthanes comme matière de moulage
B29K 83/00 - Utilisation de polymères contenant dans la chaîne principale uniquement du silicium avec ou sans soufre, azote, oxygène ou carbone comme matière de moulage
B33Y 30/00 - Appareils pour la fabrication additiveLeurs parties constitutives ou accessoires à cet effet
B33Y 70/10 - Composites de différents types de matériaux, p. ex. mélanges de céramiques et de polymères ou mélanges de métaux et de biomatériaux
C09D 11/102 - Encres d’imprimerie à base de résines artificielles contenant des composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone
Various examples are provided related to structured document access. In some examples, a structured documentation access service identifies a structured documentation request, processes structured documentation or electronic documents according to user selected options specified in the request, and generates a user interface to include subsection files, subsection summaries, object data including image-based objects and text-based objects, a result of an experiment defined by the request, or any combination thereof.
(1-a-b-c-d...n)abc.n233(1), where the subscript "a" represents the molar fraction of element M2, "b" represents the molar fraction of element M3, "c" represents the molar fraction of element M4, and "n" represents molar fraction of element MN (in the metal oxide of formula (1)); and where the sum of a+b+c+d+..,+n is less than 1; where M1 represents a base element derived from a metal oxide that has a density of less than or equal to 7.0 grams per cubic centimeter, while M2, M3, M4,.. MN each represent a different element derived from the plurality of metal oxides each of which have a density greater than 7.0 g/cm3.
C01F 17/241 - Composés ne contenant que des métaux des terres rares comme l'élément métallique le seul anion étant oxyde ou hydroxyde contenant plusieurs métaux des terres rares, p. ex. NdPrO3 ou LaNdPrO3
C04B 35/01 - Produits céramiques mis en forme, caractérisés par leur compositionCompositions céramiquesTraitement de poudres de composés inorganiques préalablement à la fabrication de produits céramiques à base d'oxydes
C04B 35/622 - Procédés de mise en formeTraitement de poudres de composés inorganiques préalablement à la fabrication de produits céramiques
C23C 18/12 - Revêtement chimique par décomposition soit de composés liquides, soit de solutions des composés constituant le revêtement, ne laissant pas de produits de réaction du matériau de la surface dans le revêtementDépôt par contact par décomposition thermique caractérisée par le dépôt sur des matériaux inorganiques, autres que des matériaux métalliques
Provided herein are devices, systems, and methods for monitoring lesion or treated area in a tissue during focal ablation or cell membrane disruption therapy.
A61B 5/0538 - Mesure de l'impédance ou de la conductivité électrique d'une partie du corps invasive, p. ex. en utilisant un cathéter
A61B 5/01 - Mesure de la température de parties du corps
G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
55.
TREATMENT PLANNING SYSTEM FOR IMMUNOTHERAPY ENHANCEMENT VIA NON-THERMAL ABLATION
Described herein are methods and systems of performing immunotherapy on a subject and/or determining if a subject will be responsive to ablation immunotherapy.
A61B 18/12 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par chauffage en faisant passer des courants à travers les tissus à chauffer, p. ex. des courants à haute fréquence
A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
56.
MULTI-AGENT COOPERATIVE PERCEPTION THROUGH PROBABILISTIC CLASSIFICATION MAP FUSION
Multi-agent cooperative perception concepts are described. An example method can include generating a first probabilistic classification map comprising a first probability that a state of a location in an external environment around a vehicle at a first time corresponds to at least one defined class. The method can also include obtaining a second probabilistic classification map comprising a second probability that the state of the location at a second time corresponds to the defined class(es). The method can also include calculating a third probability that the state of the location at a third time corresponds to the defined class(es) based on the first probability, the second probability, a difference in time between the first time and the third time, and a difference in time between the second time and the third time. The method can also include performing an operation associated with the vehicle based on the third probability.
G06V 20/58 - Reconnaissance d’objets en mouvement ou d’obstacles, p. ex. véhicules ou piétonsReconnaissance des objets de la circulation, p. ex. signalisation routière, feux de signalisation ou routes
G06V 10/82 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant les réseaux neuronaux
G06V 10/25 - Détermination d’une région d’intérêt [ROI] ou d’un volume d’intérêt [VOI]
57.
BACTERIAL STRAINS THAT ENHANCE CROP LEGUME PLANT GROWTH
Disclosed herein are compositions containing Pseudomonas strains referred to herein as Bullseye and Pancake and/or extracts from Pseudomonas strain cultures and methods of making and using the same. Also disclosed herein are methods for increasing crop legume plant growth using the disclosed compositions. The compositions are effective as well as environmentally benign and are not detrimental to human or animal health. Also disclosed are methods for extracting plant growth promoting rhizobacteria (PGPR) from nodules of a soybean plant.
Provided are modified bacteria and derivatives thereof that express nucleotide sequence encoding an antigen of a viral family selected from the group comprising Retroviridae (e.g., HIV, including a HIV Fusion Peptide antigen), Orthomyxoviridae, Paramyxoviridae, Arenaviridae, 5 Filoviridae, and/or Coronaviridae (e.g., an SARS-CoV, SARS-CoV-2 Fusion Peptide, and/or PEDV). In some embodiments, the bacterium has a reduced genome and induces an enhanced immune response against the viral antigen of interest when administered to a subject. In some embodiments, the viral (e.g., SARS-CoV, 10 SARS-CoV-2, PEDV, and/or HIV) antigen is expressed on a surface of a bacterium. Also provided are method for producing antibodies against viral antigens, vaccine compositions, methods for vaccinating subjects, methods for treating viral infections in subjects, and expression vectors for expressing viral antigens including but not limited to coronavirus (e.g., SARS-CoV, SARS-CoV-2, and/or PEDV) antigens and/or HIV antigens on the surface of reduced 15 genome bacteria.
Cancer is a significant cause of mortality and morbidity worldwide. One of the principal impediments to the broad success of conventional chemotherapy is poor delivery to and transport within the tumor microenvironment (TME), caused by irregular and leaky vasculature, the lack of functional lymphatics, and underscored by the overproduction of extracellular matrix (ECM) proteins such as collagen. Described herein are engineered Salmonella Typhimurium (S. Typhimurium) bacteria and uses thereof. In some embodiments, the engineered S. Typhimurium bacteria comprises an exogenous collagenase. Also described in exemplary embodiments herein methods of using the engineered S. Typhimurium bacteria, such as part of a,cancer therapy.
This disclosure is related to llama-derived nanobodies of which the corresponding sequences are provided, corresponding to the variable domain (VHH) of llama heavy chain antibodies recognizing epitopes of the Spike protein of SARS-COV-2, some of them, directed to the receptor binding domain, RBD. The nanobodies disclosed herein have important scientific significance and application prospects, they can be labeled or fused with fluorochromes and enzymes to be used as reagents for immunodetection of the virus. Most importantly, the disclosed nanobodies can be used in the development of a bio-drug for the prevention and clinical treatment of infection and diseases caused by SARS-COV-2.
The embodiments described herein are directed to various non-linear electrical devices in which charge flow is confined to two dimensions, so the charge flow occurs in what is called a two-dimensional system (2DS) or a two-dimensional electron system (2DES). A 2DS or 2DES can either exist in a natively two-dimensional material, such as graphene, potentially sandwiched between other materials, or in a quantum well sandwiched in semiconductor layers (e.g., a semiconductor heterostructure). A 2DS or 2DES can also be contained in certain threedimensional materials that enforce a predominantly two-dimensional charge flow. The devices exploit the non-linearity in current-voltage characteristics due to electron-electron interactions, either in the electronic ballistic or hydrodynamic transport regimes. The strength of the nonlinearity depends on the device geometry imposed on the 2DS or 2DES.
H01L 29/778 - Transistors à effet de champ avec un canal à gaz de porteurs de charge à deux dimensions, p.ex. transistors à effet de champ à haute mobilité électronique HEMT
B82Y 10/00 - Nanotechnologie pour le traitement, le stockage ou la transmission d’informations, p. ex. calcul quantique ou logique à un électron
H01L 29/06 - Corps semi-conducteurs caractérisés par les formes, les dimensions relatives, ou les dispositions des régions semi-conductrices
In one aspect, the disclosure relates to azide-containing poly(ether imide) polymers (PEIs; N3-PEI-N3) synthesized via a heterogenous diazotizationazidation reaction. In one aspect, the azide-containing PEIs can be solution-cast into films and then thermally crosslinked. In a further aspect, the crosslinked PEIs (X-PEIs) exhibit superior thermal and mechanical properties. In a still further aspect, X-PEIs display outstanding resistance to classical solvents for conventional PEI, including THF, DCM, chloroform, DMF, and NMP. In another aspect, with an initial number average molecular weight (Mn) of 8.9 kDa, the disclosed azide-containing PEIs have a high crosslinking density and thus possess desirable thermal, mechanical, and solvent resistance properties.
Solid-infused surfaces and articles having solid-infused surfaces are provided. The solid-infused surface includes (a) a substrate with a roughened surface having multi-scale surface roughness and a plurality of substrate asperities, and (b) a low surface-energy polymer coating a portion of the roughened surface forming the solid-infused surface having a fraction of the substrate asperities exposed on the solid-infused surface. The surfaces can be useful, in particular, for promoting condensation heat transfer performance. The articles and surfaces can include electronic components, optical components, or even pipes and other conduits for transporting certain fluids. Methods of making and methods of using the solid-infused surfaces are also provided.
Described in certain example embodiments herein are methods of and compositions for treating a Snordl l6 deficiency disease or symptom thereof with conjugated linoleic acid (CLA) or a formulation thereof. In some embodiments, the Snordl l6 deficiency disease is Prader-Willi Syndrome. Described in certain example embodiments herein are methods of and compositions for treating Nhlh2 associated hypogonadism with CLA or a formulation thereof.
A61K 31/201 - Acides carboxyliques, p. ex. acide valproïque ayant un groupe carboxyle lié à une chaîne acyclique d'au moins sept atomes de carbone, p. ex. acides stéarique, palmitique ou arachidique ayant une ou deux doubles liaisons, p. ex. acides oléique ou linoléique
Methods, systems, and apparatus, including computer programs encoded on computer storage media, for training and deploying machine-learned communication over multi-input-multi-output (MIMO) channels. One of the methods includes: determining a transmitter and a receiver, at least one of which implements a machine-learning network; determining a MIMO channel model; determining first information; using the transmitter to process the first information and generate first RF signals representing inputs to the MIMO channel model; determining second RF signals representing outputs of the MIMO channel model, each second RF signal representing aggregated reception of the first RF signals altered by transmission through the MIMO channel model; using the receiver to process the second RF signals and generate second information as a reconstruction of the first information; calculating a measure of distance between the second and first information; and updating the machine-learning network based on the measure of distance between the second and first information.
H04B 7/0452 - Systèmes MIMO à plusieurs utilisateurs
G06N 3/006 - Vie artificielle, c.-à-d. agencements informatiques simulant la vie fondés sur des formes de vie individuelles ou collectives simulées et virtuelles, p. ex. simulations sociales ou optimisation par essaims particulaires [PSO]
G06N 3/044 - Réseaux récurrents, p. ex. réseaux de Hopfield
H04B 7/06 - Systèmes de diversitéSystèmes à plusieurs antennes, c.-à-d. émission ou réception utilisant plusieurs antennes utilisant plusieurs antennes indépendantes espacées à la station d'émission
66.
SMALL-SCALE SOLID-STATE ADDITIVE MANUFACTURING TOOLS AND DESIGNS
An apparatus may include a modular tool positioned in a spaced apart relationship with a rotatable head holding a feed rod for additive manufacturing, the modular tool comprising: a first portion having a first aperture that slidably allows the feed rod to pass through, a second portion coupled with the first portion, the second portion having a second aperture aligned with the first aperture, the second aperture slidably allows the feed rod to pass through, the second portion having a melting point that is less than the melting point of the first portion, a bearing coupled with at least one of the first portion or the second portion.
B23K 20/12 - Soudage non électrique par percussion ou par une autre forme de pression, avec ou sans chauffage, p. ex. revêtement ou placage la chaleur étant produite par frictionSoudage par friction
B22F 12/00 - Appareils ou dispositifs spécialement adaptés à la fabrication additiveMoyens auxiliaires pour la fabrication additiveCombinaisons d’appareils ou de dispositifs pour la fabrication additive avec d’autres appareils ou dispositifs de traitement ou de fabrication
B33Y 30/00 - Appareils pour la fabrication additiveLeurs parties constitutives ou accessoires à cet effet
A system and method for additive manufacturing are described. A system includes an additive manufacturing tooling head configured to deposit a heated material to form a workpiece, a tooling controller configured direct the tooling head through a sequence of additive manufacturing process actions, and a chamber comprising a build surface to support the workpiece during the sequence of additive manufacturing process actions. At least one thermal medium is positioned within the chamber. The tooling controller is further configured to determine a thermal gradient between the workpiece and the portion of the heated material based on the temperature of the workpiece and the temperature of the portion of the heated material to be deposited, and control the at least one thermal medium contained within the chamber over time based at least in part on a predetermined thermal gradient range.
Methods of making high-strength aluminum and high-strength aluminum articles made therefrom are provided. The methods include high strain rate severe plastic deformation (SPD) process applied to aluminum alloys containing aluminum and one or more of copper, magnesium, and zinc and being substantially free of chromium, zirconium, and manganese.
C22F 1/047 - Modification de la structure physique des métaux ou alliages non ferreux par traitement thermique ou par travail à chaud ou à froid de l'aluminium ou de ses alliages d'alliages avec le magnésium comme second constituant majeur
B23K 20/12 - Soudage non électrique par percussion ou par une autre forme de pression, avec ou sans chauffage, p. ex. revêtement ou placage la chaleur étant produite par frictionSoudage par friction
C22C 21/16 - Alliages à base d'aluminium avec le cuivre comme second constituant majeur avec du magnésium
70.
NUCLEAR REACTOR CORE WITH ROTATING FUEL MODULES AND RELATED SYSTEMS
Nuclear reactor cores and related systems are described herein. An example nuclear reactor core includes a plurality of fuel modules, where each of the plurality of fuel modules includes nuclear fuel; at least one fuel-module actuator mechanically coupled to at least one of the plurality of fuel modules, where the at least one fuel-module actuator is configured to rotate the at least one of the plurality of fuel modules; and at least one neutron source configured to emit neutrons and trigger a fission chain reaction in the at least one of the plurality of fuel modules.
G21C 7/30 - Commande de la réaction nucléaire par déplacement du combustible du réacteur ou des éléments combustibles
G21C 3/40 - Combinaison structurelle d'un élément combustible avec un élément thermo-électrique pour la production directe d'énergie électrique à partir de la chaleur de fission
Various aspects of an implant for plantar plate repair and a surgical method of plantar plate repair using the implant are described. In one example, the implant includes a female component and a male component. The female component includes an open barrel having an outer surface and an inner surface, a flange cap at one end of the open barrel, and a recessed tiedown bar that extends between openings through the flange cap. The openings through the flange cap extending into the open barrel of the female component. The male impant includes an open barrel portion, a pair of fingers extending from one end of the open barrel portion, and a flange cap at another end of the open barrel portion. The male implant also includes an opening through the flange cap, extending into the open barrel portion of the male implant.
Real-time vehicle radar interference mitigation concepts are described. In one embodiment, a method to mitigate interference for a vehicle radar includes detecting a target object in a vicinity of a vehicle. The detection of the target object generates an intended signal. The method further includes detecting an interference signal in the vicinity of the vehicle and receiving a return signal that includes the intended signal and the interference signal. The method further includes transforming the return signal to a frequency-time domain return signal using a short-time Fourier transform, determining a reconstructed interference signal in a frequency-time domain, transforming the reconstructed interference signal to a time domain, and removing the interference signal in the time domain from the return signal to isolate the intended signal based on the reconstructed interference signal in the time domain. The method further includes employing a parallel and computational efficient structure to deliver real-time output.
The present disclosure concerns processes and the combinations thereof for the enrichment and/or isolation of valuable metals from municipal solid waste incineration (MSWI) ash. Included are processes of size separation, froth floatation, magnetic separation, specific gravity separation, chemical separation, as well as the removal of lime. BY utilizing two or more, circuits of treatment are also provided that allow for fractionation of enriched valuable metals(s) from which purification thereof can be readily achieved.
Aspects of a transient control scheme for a multiphase power converter are described. In one example, a power converter system includes a multiphase power converter that includes a plurality of converter phases, with each converter phase comprising a switching transistor and an inductor coupled between an input power source and a load. The power converter system also includes a controller configured to distribute an on-time signal to each converter phase during operation of the multiphase power converter. The controller includes circuitry configured to enable an on-time signal phase overlap between non-subsequent phases of the multiphase power converter when a load current increase is detected during a transient state of the multiphase power converter. The on-time signal phase overlap refers to a simultaneous on-state of two or more switching transistors of the non-subsequent phases during a duration of time within the transient state.
H02M 1/14 - Dispositions de réduction des ondulations d'une entrée ou d'une sortie en courant continu
H02M 3/158 - Transformation d'une puissance d'entrée en courant continu en une puissance de sortie en courant continu sans transformation intermédiaire en courant alternatif par convertisseurs statiques utilisant des tubes à décharge avec électrode de commande ou des dispositifs à semi-conducteurs avec électrode de commande utilisant des dispositifs du type triode ou transistor exigeant l'application continue d'un signal de commande utilisant uniquement des dispositifs à semi-conducteurs avec commande automatique de la tension ou du courant de sortie, p. ex. régulateurs à commutation comprenant plusieurs dispositifs à semi-conducteurs comme dispositifs de commande finale pour une charge unique
Various examples are provided related to a block cipher adaptation of the Galois Extension Fields (GEF) combination technique. In one example, a GEF-based block encryption includes forming an output from a PRNG into a key matrix, where the key matrix is formatted as an invertible square matrix; applying a GEF operation to the key matrix to map elements to a closed subset in a higher-order GEF space; mapping plaintext to a plaintext matrix; applying a GEF operation to the plaintext matrix to map elements to the higher-order GEF space; combining the plaintext matrix and the key matrix to produce a vector of ciphertext in the higher-order GEF space; reducing the vector to a reduced vector of ciphertext using an inverse of the GEF operation; and during the reducing, applying a ceiling operation to bijectively map elements in the reduced vector to a closed subset. Another example includes GEF-based block decryption.
H04L 9/06 - Dispositions pour les communications secrètes ou protégéesProtocoles réseaux de sécurité l'appareil de chiffrement utilisant des registres à décalage ou des mémoires pour le codage par blocs, p. ex. système DES
A device may include a substrate of a first conductivity type, the first conductivity type being one of a n-type conductivity and a p-type conductivity, the substrate having a base surface. A device may include a first terminal coupled with the base surface of the substrate, a first semiconductor region disposed over the substrate, the substrate positioned between the first semiconductor region and the first terminal, the first semiconductor region including a top surface, which defines a plurality of trenches having sidewalls, the plurality of trenches separated by a plurality of pillars, the first semiconductor region formed of a first material with the first conductivity type, a second semiconductor region disposed over the sidewalls of the first semiconductor region to form a superjunction with the first semiconductor region, the second semiconductor region formed of a second material different from the first material and having a second conductivity type.
A configurable microreactor for testing and education is described. The microreactor includes a reactor core comprising a plurality of fuel rods, a plurality of guide tubes, and a plurality of rotating control drums configured to control operation of the microreactor. Further, the microreactor includes a testing cavity disposed in an area within the reactor configured to store an item therein for experimentation; a plurality of beam ports; a moveable particle filter ring; a moveable spectrum shifter; and at least one sensor. A computing device is directed to receive measurements from the at least one sensor and perform a physics-based analysis of the microreactor using one or more machine learning (ML) routines.
G09B 23/20 - Modèles à usage scientifique, médical ou mathématique, p. ex. dispositif en vraie grandeur pour la démonstration pour la physique pour la physique ou la technologie nucléaire
Multi-chip module packaging technologies for GaN and other devices are described. The power module packaging technology described can be applied to all types of medium-voltage devices, such as silicon (Si), silicon carbide (SiC), gallium nitride (GaN), or the latest gallium oxide (Ga2O3) devices. In one example, a power module includes a first substrate, a second substrate, a sintered-silver semiconductor die pillar, the pillar being positioned between the first substrate and the second substrate, a terminal on a first side of the power module, and a terminal on a second side of the power module.
H01L 23/498 - Connexions électriques sur des substrats isolants
H01L 21/48 - Fabrication ou traitement de parties, p. ex. de conteneurs, avant l'assemblage des dispositifs, en utilisant des procédés non couverts par l'un uniquement des groupes ou
H01L 23/00 - Détails de dispositifs à semi-conducteurs ou d'autres dispositifs à l'état solide
H01L 23/373 - Refroidissement facilité par l'emploi de matériaux particuliers pour le dispositif
H01L 25/00 - Ensembles consistant en une pluralité de dispositifs à semi-conducteurs ou d'autres dispositifs à l'état solide
H01L 25/07 - Ensembles consistant en une pluralité de dispositifs à semi-conducteurs ou d'autres dispositifs à l'état solide les dispositifs étant tous d'un type prévu dans une seule des sous-classes , , , , ou , p. ex. ensembles de diodes redresseuses les dispositifs n'ayant pas de conteneurs séparés les dispositifs étant d'un type prévu dans la sous-classe
79.
HIGH-VISCOSITY RESINS IN MASK PROJECTION STEREOLITHOGRAPHY
A method for fabricating an item using a high-viscosity photoresin is described that includes providing tooling that comprises an extruder and a light source: depositing. by the extruder of the tooling. a first non-patterned layer of the high-viscosity photoresin: selectively photocuring. by the light source of the tooling. the first non-patterned layer into a first predetermined layer shape: depositing. by the extruder of the tooling. a second nonpatterned layer of the high-viscosity photoresin: and selectively photocuring. by the light source of the tooling. the second non-patterned layer into a second predetermined layer shape.
B29C 64/129 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux utilisant des couches de liquide à solidification sélective caractérisés par la source d'énergie à cet effet, p. ex. par irradiation globale combinée avec un masque
A medical system for ablating a tissue site with real-time monitoring during an electroporation treatment procedure. A pulse generator generates a pre-treatment (PT) test signal prior to the treatment procedure and intra-treatment (IT) test signals during the treatment procedure. A treatment control module determines impedance values from the PT test signal and IT test signals and determines a progress of electroporation and an end point of treatment in real-time based on the determined impedance values while the treatment progresses.
A61B 18/12 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par chauffage en faisant passer des courants à travers les tissus à chauffer, p. ex. des courants à haute fréquence
A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
A61B 18/18 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par application de radiations électromagnétiques, p. ex. de micro-ondes
A61B 34/10 - Planification, simulation ou modélisation assistées par ordinateur d’opérations chirurgicales
C12N 13/00 - Traitement de micro-organismes ou d'enzymes par énergie électrique ou ondulatoire, p. ex. par magnétisme, par des ondes sonores
81.
A NOVEL PROCESS AND FLOTATION CHEMISTRY FOR VALUABLE METAL RECOVERY FROM MUNICIPAL SOLID WASTE INCINERATION (MSWI) ASH
The present disclosure concerns processes and the combinations thereof for the enrichment and/or isolation of valuable metals from municipal solid waste incineration (MSWI) ash. Included are processes of size separation, froth floatation, magnetic separation, specific gravity separation, chemical separation, as well as the removal of lime. BY utilizing two or more, circuits of treatment are also provided that allow for fractionation of enriched valuable metals(s) from which purification thereof can be readily achieved.
A62D 3/33 - Procédés pour rendre les substances chimiques nuisibles inoffensives ou moins nuisibles en effectuant un changement chimique dans les substances par réaction avec des agents chimiques par fixation chimique de la substance nuisible, p. ex. par chélation ou complexation
A62D 3/30 - Procédés pour rendre les substances chimiques nuisibles inoffensives ou moins nuisibles en effectuant un changement chimique dans les substances par réaction avec des agents chimiques
A method for forming an optical fiber having at least one of a microresonator and a coupler integrated therein is described. The method includes providing an optical fiber having a light guiding core. modifying at least one region of the optical fiber using a laser, immersing the optical fiber having the at least one region as modified inside an etchant that selectively etches the at least one region as modified to generate at least one of a microresonator and a coupler integrated in the optical fiber, and removing the optical fiber from the etchant. The optical fiber as removed from the etchant may include the at least one of the microresonator and the coupler. The method may further include heating the optical fiber using, for example, a CO2 laser or other heating apparatus, to smoothen surface irregularities of at least one of the microresonator and the coupler.
G02B 6/293 - Moyens de couplage optique ayant des bus de données, c.-à-d. plusieurs guides d'ondes interconnectés et assurant un système bidirectionnel par nature en mélangeant et divisant les signaux avec des moyens de sélection de la longueur d'onde
83.
METHODS AND APPARATUS FOR EVAPORATION BASED LIQUID TRANSPORT
This disclosure provides an apparatus, including a first plate having a first transport surface and a second plate having a second transport surface. The second plate is positioned at an acute angle with respect to the first plate such that a first transport surface of the first plate faces the second transport surface of the second plate. The first transport surface and the second transport surface are hydrophobic. The apparatus also includes one or more liquid droplets positioned between and in contact with the first transport surface and the second transport surface. During evaporation, the liquid droplet will automatically move towards the cusp of the first plate and the second plate.
Planar, double-side cooled half-bridge power modules using sintered-silver interposers and all sintered-silver joints are described. Thermo-mechanical simulations showed that use of the sintered-silver interposers reduce the thermo-mechanical stresses at vulnerable interfaces as compared to using solid copper interposers. The porous sintered-silver interposers are also easily deformable under a low load, which improves the yield of module interconnections in the presence of imperfections caused by variations in die thickness, interposer height, and substrate distortion. Results on the electrical performance of the modules validate the fabrication approach for the modules, for making high power-density converters with reliable operations at high junction temperatures.
H01L 23/498 - Connexions électriques sur des substrats isolants
H01L 23/00 - Détails de dispositifs à semi-conducteurs ou d'autres dispositifs à l'état solide
H01L 23/528 - Configuration de la structure d'interconnexion
H01L 29/16 - Corps semi-conducteurs caractérisés par les matériaux dont ils sont constitués comprenant, mis à part les matériaux de dopage ou autres impuretés, seulement des éléments du groupe IV de la classification périodique, sous forme non combinée
85.
METHODS AND COMPOSITIONS FOR CALIBRATED LABEL-FREE SURFACE-ENHANCED RAMAN SPECTROSCOPY
In one aspect, the disclosure relates to methods of label-free surface-enhanced Raman spectroscopy (SERS) comprising plasmonically enhanced electronic Raman scattering (ERS) signals from metal nanostructures as an internal calibration standard to improve multivariate analysis of living biological systems, and the uses of the methods therein. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
Adapting user interface designs for specific tasks performed by different users is a challenging yet important problem. Automatically adapting visualization designs to users and contexts (e.g., tasks, display devices, environments, etc.) can theoretically improve human-computer interaction to acquire insights from complex datasets. However, effectiveness of any specific visualization is moderated by individual differences in knowledge, skills, and abilities for different contexts. A modeling framework called Personalized Recommender System for Information visualization Methods via Extended matrix completion (PRIME) is described for recommending the optimal visualization designs for individual users in different contexts.
Various embodiments of a system and method for enriching a concentration of components of interest in an air flow are described. The system includes an apparatus for enriching a concentration of components of interest in an air flow. The apparatus includes a chamber and a tube having a tube wall made of a selectively permeable material positioned within the chamber. A first end of the tube is connected to the inlet port of the chamber and a second end of the tube is connected to the outlet port of the chamber. The selectively permeable material has a lower permeability to components of interest than to inert gases, and the selectively permeable material is non-reactive with components of interest. The apparatus is configured to receive a sample stream and the chamber is maintained at a chamber pressure that is different than a stream pressure of the sample stream.
B01D 53/22 - Séparation de gaz ou de vapeursRécupération de vapeurs de solvants volatils dans les gazÉpuration chimique ou biologique des gaz résiduaires, p. ex. gaz d'échappement des moteurs à combustion, fumées, vapeurs, gaz de combustion ou aérosols par diffusion
Computation pipeline-dataset exploration, visualization, and recommendation concepts are described. For example, a method can include learning first visualization latent-space features of different datasets represented in a first two-dimensional latent space and second visualization latent-space features of different computation pipelines represented in a second two-dimensional latent space. The method can also include modeling dataset-pipeline interactions between the different datasets and the different computation pipelines based on the first visualization latent-space features and the second visualization latent-space features. The method can also include learning relationships between the first visualization latent-space features and the second visualization latent-space features based on modeling the dataset-pipeline interactions. In another example, the method can further include generating a visual representation of the relationships and the dataset-pipeline interactions. The visual representation can include latitude and longitude data indicative of the relationships and altitude data indicative of the dataset-pipeline interactions.
Embodiments of the present invention include methods of targeting acidosis (low pH) within the tumor microenvironment (TME) through the use of cathodic electrochemical reactions (CER). Low pH is oncogenic by supporting immunosuppression. Electrochemical reactions create local pH effects when a current passes through an electrolytic substrate such as biological tissue. Electrolysis has been used with electroporation (destabilization of the lipid bilayer via an applied electric potential) to increase cell death areas. However, the regulated increase of pH through only the cathode electrode has been ignored as a possible method to alleviate TME acidosis, which could provide substantial immunotherapeutic benefits. Here, ex vivo modeling shows that CERs can intentionally elevate pH to an anti-tumor level and that increased alkalinity promotes activation of naive macrophages. Embodiments of the invention include pairing CER treatment protocols with existing electric field-based cancer therapies or use as a stand-alone therapy.
A61B 18/12 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par chauffage en faisant passer des courants à travers les tissus à chauffer, p. ex. des courants à haute fréquence
Peach production in temperate regions is often threatened by spring frost during late winter or early spring. Currently, effective methods to mitigate frost damage are largely lacking. Plant growth regulators (PGR) to enhance cold hardiness or to delay budburst and bloom date until the risk of frost damage has passed or diminished are considered to hold high potential in ameliorating frost damage due to their high efficiency, relatively low cost, and ease of implementation. However, proper PGRs that can delay bloom effectively and safely are yet to be identified. Disclosed herein is a method for delaying flowering of deciduous fruit trees that involves applying to the tree an effective amount of a jasmonate inhibitor, such as diethyldithiocarbamate (DIECA).
A01G 7/06 - Traitement des arbres ou des plantes en cours de croissance, p. ex. pour prévenir la décomposition du bois, pour teinter les fleurs ou le bois, pour prolonger la vie des plantes
A01G 22/05 - Légumes-fruits, p. ex. fraises, tomates ou concombres
Methods, systems, and apparatus, including computer programs encoded on computer storage media, for training and deploying machine-learned identification of radio frequency (RF) signals. One of the methods includes: determining an RF signal configured to be transmitted through an RF band of a communication medium; determining first classification information that is associated with the RF signal, and that includes a representation of a characteristic of the RF signal or a characteristic of an environment in which the RF signal is communicated; using at least one machine-learning network to process the RF signal and generate second classification information as a prediction of the first classification information; calculating a measure of distance between (i) the second classification information that was generated by the at least one machine-learning network, and (ii) the first classification information associated with the RF signal; and updating the at least one machine-learning network based on the measure of distance.
An apparatus may include a microfluidic chip including at least one microfluidic channel and a first at least one electrical interconnect. An apparatus may include a circuit board having at least one interface interconnect and a second at least one electrical interconnect electrically coupled with the first at least one electrical interconnect of the microfluidic chip. An apparatus may include a cartridge enclosing the microfluidic chip and the circuit board, the cartridge including at least one opening allowing access to the at least one microfluidic channel on the microfluidic chip and the at least one interface interconnect.
Power systems including converters that exhibit reduced common mode voltage emissions are described. In one example, a power converter system includes an input and an output, a multi-level switch bridge coupled between the input and the output, an input capacitor branch coupled across the input, an output capacitor branch coupled across the output, and a controller configured to generate switching control signals for the multi-level buck-boost switch bridge. The multi-level switch bridge also includes a plurality of inductors in one example. In one case, a quadrangular or quadrangle control mode can be relied upon to switch the multi-level switch bridge, to minimize the ripple in the inductors, achieve zero voltage switching, reduce common mode electromagnetic interference emission by the converter, and for other benefits.
H02M 3/335 - Transformation d'une puissance d'entrée en courant continu en une puissance de sortie en courant continu avec transformation intermédiaire en courant alternatif par convertisseurs statiques utilisant des tubes à décharge avec électrode de commande ou des dispositifs à semi-conducteurs avec électrodes de commande pour produire le courant alternatif intermédiaire utilisant des dispositifs du type triode ou transistor exigeant l'application continue d'un signal de commande utilisant uniquement des dispositifs à semi-conducteurs
H02M 1/08 - Circuits spécialement adaptés à la production d'une tension de commande pour les dispositifs à semi-conducteurs incorporés dans des convertisseurs statiques
94.
SWITCHING-CYCLE VOLTAGE DEVIATION CONTROL FOR MODULAR MULTILEVEL CONVERTERS
Aspects of switching-cycle voltage deviation control for modular multilevel converters (MMCs) are described. In one example, an upper switching action of an upper power cell is determined within a time duration of a switching cycle for an MMC. In addition, a lower switching action of a lower power cell is determined within the time duration of the switching cycle for the MMC. In addition, a delay is generated between the upper switching action and the lower switching action to reduce capacitor voltage deviation between the upper power cell and the lower power cell during the switching cycle. The upper power cell is located in an upper arm of a phase leg of the MMC, while the lower power cell is located in a lower arm of the phase leg of the MMC.
H02M 7/483 - Convertisseurs munis de sorties pouvant chacune avoir plus de deux niveaux de tension
H02M 1/00 - Détails d'appareils pour transformation
H02M 7/5395 - Transformation d'une puissance d'entrée en courant continu en une puissance de sortie en courant alternatif sans possibilité de réversibilité par convertisseurs statiques utilisant des tubes à décharge avec électrode de commande ou des dispositifs à semi-conducteurs avec électrode de commande utilisant des dispositifs du type triode ou transistor exigeant l'application continue d'un signal de commande utilisant uniquement des dispositifs à semi-conducteurs, p. ex. onduleurs à impulsions à un seul commutateur avec commande automatique de la forme d'onde ou de la fréquence de sortie par modulation de largeur d'impulsions
A semiconductor device includes a semiconductor region having at least one two-dimensional carrier channel of a first conductivity type, the first conductivity type being one of a n-type and a p-type conductivity, the at least one two-dimensional channel having a net charge, the semiconductor region including a first semiconductor region coupled with a drain terminal and a second semiconductor region coupled with a source terminal; and a third semiconductor region of a second conductivity type electrically coupled with a gate terminal, having a gate region and a net charge region, the net charge region disposed over the first semiconductor region and having a net charge in a depletion region that is substantially equal to the net charge of the at least one two-dimensional channel in the first semiconductor region when the semiconductor device is in an off-state.
H01L 29/778 - Transistors à effet de champ avec un canal à gaz de porteurs de charge à deux dimensions, p.ex. transistors à effet de champ à haute mobilité électronique HEMT
H01L 29/20 - Corps semi-conducteurs caractérisés par les matériaux dont ils sont constitués comprenant, à part les matériaux de dopage ou autres impuretés, uniquement des composés AIIIBV
H01L 29/205 - Corps semi-conducteurs caractérisés par les matériaux dont ils sont constitués comprenant, à part les matériaux de dopage ou autres impuretés, uniquement des composés AIIIBV comprenant plusieurs composés dans différentes régions semi-conductrices
96.
COMPOSITIONS AND METHODS OF TREATING A PI3K MEDIATED DISEASE
Described herein are compositions and formulations to treat and/or prevent a PI3K mediated disease or a symptom thereof in a subject in need thereof. In some embodiments, such compositions include engineered peptides capable of targeting PI3K or Connexin 43. Also described herein are methods of treating and/or preventing PI3K mediated disease or a symptom thereof. In some embodiments, the PI3K mediated disease is a cancer.
A61K 38/00 - Préparations médicinales contenant des peptides
A61K 31/495 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec deux azote comme seuls hétéro-atomes d'un cycle, p. ex. pipérazine
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
One or more processors control processing of radio frequency (RF) signals using a machine-learning network. The one or more processors receive as input, to a radio communications apparatus, a first representation of an RF signal, which is processed using one or more radio stages, providing a second representation of the RF signal. Observations about, and metrics of, the second representation of the RF signal are obtained. Past observations and metrics are accessed from storage. Using the observations, metrics and past observations and metrics, parameters of a machine-learning network, which implements policies to process RF signals, are adjusted by controlling the radio stages. In response to the adjustments, actions performed by one or more controllers of the radio stages are updated. A representation of a subsequent input RF signal is processed using the radio stages that are controlled based on actions including the updated one or more actions.
This disclosure provides semiconductor device including a first transistor with a first gate terminal, a first source terminal, and the first drain terminal, the first transistor being a depletion mode transistor and including a plurality of two-dimensional carrier channels of a conductivity type being one of a n-type or a p-type conductivity. The semiconductor device also includes a second transistor with a second gate terminal, a second source terminal, and a second drain terminal, the second transistor being an enhancement mode transistor, a gate-source interconnect forming an electrical connection between the first gate terminal and the second source terminal, and a drain-source interconnect forming an electrical connection between the first source terminal and the second drain terminal. The first transistor and the second transistor are fabricated on the same wafer or substrate.
H01L 29/778 - Transistors à effet de champ avec un canal à gaz de porteurs de charge à deux dimensions, p.ex. transistors à effet de champ à haute mobilité électronique HEMT
H01L 27/06 - Dispositifs consistant en une pluralité de composants semi-conducteurs ou d'autres composants à l'état solide formés dans ou sur un substrat commun comprenant des éléments de circuit passif intégrés avec au moins une barrière de potentiel ou une barrière de surface le substrat étant un corps semi-conducteur comprenant une pluralité de composants individuels dans une configuration non répétitive
H01L 27/088 - Dispositifs consistant en une pluralité de composants semi-conducteurs ou d'autres composants à l'état solide formés dans ou sur un substrat commun comprenant des éléments de circuit passif intégrés avec au moins une barrière de potentiel ou une barrière de surface le substrat étant un corps semi-conducteur comprenant uniquement des composants semi-conducteurs d'un seul type comprenant uniquement des composants à effet de champ les composants étant des transistors à effet de champ à porte isolée
H01L 29/20 - Corps semi-conducteurs caractérisés par les matériaux dont ils sont constitués comprenant, à part les matériaux de dopage ou autres impuretés, uniquement des composés AIIIBV
99.
Device and method for electroporation based treatment
The present invention relates to medical devices and methods for treating a lesion such as a vascular stenosis using non-thermal irreversible electroporation (NTIRE). Embodiments of the present invention provide a balloon catheter type NTIRE device for treating a target lesion comprising a plurality of electrodes positioned along the balloon that are electrically independent from each other so as to be individually selectable in order to more precisely treat an asymmetrical lesion in which the lesion extends only partially around the vessel.
A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures
100.
SYSTEMS AND METHODS FOR EXECUTING COMPUTE FUNCTIONS
Systems and methods for executing compute functions are disclosed. A processing circuit may be configured to: receive a first task from a first application, wherein the first task identifies a first compute function and a second compute function; determine a first order of execution of the first compute function and the second compute function based on first information in the first task; and execute the first compute function and the second compute function according to the first order.
