Abrégé

The invention relates to xanthogenate-gold compounds and to pharmaceutical formulations of these complexes, and also to medicaments which comprise these formulations for treatment of tumour, virus and autoimmune disorders influenced by activated macrophages.

Classes IPC  ?

• A61K 31/265 - Esters, p. ex. nitroglycérine, sélénocyanates d'acides carbonique, thiocarboniques, thiocarboxyliques, p. ex. acide thio-acétique, acide xanthogénique, acide trithiocarbonique
• A61K 33/24 - Métaux lourdsLeurs composés
• A61P 19/02 - Médicaments pour le traitement des troubles du squelette des troubles articulaires, p. ex. arthrites, arthroses
• A61P 35/00 - Agents anticancéreux
• A61P 31/18 - Antiviraux pour le traitement des virus ARN du HIV

Abrégé

The invention relates to associations of xanthogenates and cyclodextrins, to pharmaceutical formulations thereof and to medicaments comprising these formulations for the treatment of Alzheimer's, viral diseases, tumour diseases, cardiovascular diseases and autoimmune diseases such as rheumatism, multiple sclerosis, Alopecia areata, lupus erythematodes, stroke, pulmonary edema, or for use as radioprotectors. The associations comprise a xanthogenate of the formula (I) where R1 represents an optionally substituted aryl or alkyl radical and R2 represents a metal atom, an optionally substituted alkyl, alkoxy, amino or ammonium group or halogen, and a cyclodextrin, where the cyclodextrin may be either a substituted or an unsubstituted alpha-, beta- or gamma-cyclodextrin. The invention furthermore relates to the use of the associations for chemical syntheses.

Classes IPC  ?

• C07C 327/36 - Esters d'acides dithiocarboxyliques
• C08B 37/00 - Préparation des polysaccharides non prévus dans les groupes Leurs dérivés
• A61K 31/265 - Esters, p. ex. nitroglycérine, sélénocyanates d'acides carbonique, thiocarboniques, thiocarboxyliques, p. ex. acide thio-acétique, acide xanthogénique, acide trithiocarbonique
• A61K 31/724 - Cyclodextrines
• A61P 31/12 - Antiviraux