The present invention is in the field of enzyme and microorganism comprising such a modified enzyme to produce flavors, in particular raspberry ketone or zingerone. The enzymes of the invention are used for producing p-coumaric acid (PCA) from a tyrosine substrate, in particular from L-tyrosine. The invention also relates to microorganisms expressing such enzymes with Tyrosine Ammonia Lyase for producing flavors.
C12N 15/78 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes procaryotes autres que E. coli, p. ex. Lactobacillus, Micromonospora pour Pseudomonas
C07K 14/195 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de bactéries
The present invention relates to the field involved in the production of phenylbutanone or phenylbutanone derivative compounds, such as frambinone or zingerone, and in particular strains genetically modified to express a benzalacetone reductase.
C12N 15/52 - Gènes codant pour des enzymes ou des proenzymes
C12N 15/78 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes procaryotes autres que E. coli, p. ex. Lactobacillus, Micromonospora pour Pseudomonas
The present invention relates to the field of the production of phenylpropanoid compounds, especially that of genetically modified strains for the production of phenylpropanoid compounds. In particular, the invention relates to a genetically modified strain of Pseudomonas putida comprising a mutated AroF-I gene encoding 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP), and to the use thereof for the synthesis of phenylpropanoid compounds, in particular coumaric acid or frambinone.
C12N 15/78 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes procaryotes autres que E. coli, p. ex. Lactobacillus, Micromonospora pour Pseudomonas
C12P 17/06 - Préparation de composés hétérocycliques comportant O, N, S, Se ou Te comme uniques hétéro-atomes du cycle l'oxygène comme unique hétéro-atome du cycle contenant un hétérocycle à six chaînons, p. ex. fluorescéine
C12P 19/32 - Nucléotides avec un système cyclique condensé, contenant un cycle à six chaînons, comportant deux atomes d'azote dans le même cycle, p. ex. nucléotides puriques, dinucléotide de la nicotinamide-adénine
The present invention is in the field of genetically modified enzyme and microorganism comprising such a modified enzyme for the production of raspberry ketone or zingerone. The modified enzyme is a polyketide synthase (PKS) issued or derived from a wild type PKS. The modified PKS has the capability to produce vanillylidene acetone from feruloyl-CoA and/or 4-hydroxybenzalacetone from 4-coumaroyl-CoA in a more effective way as compared to wild type BAS or wild type PmPKS, in particular in recombinant bacteria strains.
The present invention relates to the field involved in the production of phenylbutanone or phenylbutanone derivative compounds, such as frambinone or zingerone, and in particular strains genetically modified to express a benzalacetone reductase.
C12N 9/02 - Oxydoréductases (1.), p. ex. luciférase
C12N 15/78 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes procaryotes autres que E. coli, p. ex. Lactobacillus, Micromonospora pour Pseudomonas
The present invention relates to the field of the production of phenylpropanoid compounds, especially that of genetically modified strains for the production of phenylpropanoid compounds. In particular, the invention relates to a genetically modified strain of Pseudomonas putida comprising a mutated AroF-I gene encoding 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP), and to the use thereof for the synthesis of phenylpropanoid compounds, in particular coumaric acid or frambinone.
09 - Appareils et instruments scientifiques et électriques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Bioinformatics software; Computer-aided design (CAD) software; Data processing equipment; Scientific apparatus and instruments. Analysis in the field of molecular biology; Writing of computer programs for biotechnological applications; Stem cell research; Design, development and programming of computer software; Software design for others; Computer software design; Scientific research; Technical research projects and studies; Research and development of new products for others; Maintenance of computer software; Maintenance and updating of computer software; Computer programming; Computer system design; Technical assessments relating to design; Laboratory analysis in the field of bacteriology; Scientific research and analysis; DNA screening for scientific research purposes.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Chemicals for use in industry and science; Chemical preparations for use in photography; Chemicals for use in agriculture; Chemicals used in horticulture; Chemicals used in forestry; Unprocessed plastics; Fertilizers; Fire extinguishing compositions; Metal tempering preparations; Chemical substances for preserving foodstuffs; Tanning substances; Salt for preserving, other than for foodstuffs; Chemical reagents, other than for medical or veterinary purposes; Decolorants for industrial purposes. Pharmaceuticals; Veterinary preparations; Sanitary preparations for medical purposes; Disinfectant soap; Medicated soap; Medicated dentifrices; Medicated shampoos; Dietetic foods adapted for medical purposes; Dietetic food adapted for veterinary use; Disinfectants; Antibacterial handwashes; Preparations for destroying noxious animals; Fungicides; Weedicides; Chemical preparations for pharmaceutical purposes; Parasiticides. Technical assessments relating to design; Scientific research; Technical research projects and studies; Design of computers for others; Development of computers; Computer software design; Software development; Research and development of new products for others; Conducting technical project studies; Architecture; Design of interior decor; Installation of computer software; Maintenance of computer software; Updating of computer software; Rental of computer software; Computer programming; Computer system analysis; Computer system design; Consultancy in the design and development of computer hardware; Digitization of documents; Software as a service [SaaS]; Cloud computing; Information technology [IT] consultancy; Server hosting.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
31 - Produits agricoles; animaux vivants
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Chemicals for use in industry and science; Chemical reagents for molecular biology, other than for medical or veterinary use; Bacterial substances for scientific use; Bacterial preparations for use in horticulture; Bacterial preparations for use in forestry; Bacterial preparations for use in agriculture; Bacterial substances for industrial use; Living microorganisms, other than for medical or veterinary use; Enzymes for use in fermentation; Fermentation extracts for industrial purposes; Chemicals for use in fermenting; Yeast for scientific purposes; Enzyme substrates for scientific purposes. Agricultural and aquacultural crops, horticulture and forestry products; Plants; Natural plants; Trees; Trees and forestry products; Unsawn timber. Analysis in the field of molecular biology; Research relating to molecular sciences; Research and development in the field of biotechnology; Information on the subject of scientific research in the field of biochemistry and biotechnology; Structural and functional analysis of genomes; Biotechnological research relating to enzymatic synthesis; Technical assessments relating to design; Scientific research; Computer aided scientific research services; Software design and development; Research, development, design and upgrading of computer software; Design, maintenance, development and updating of computer software; Research and development of new products for others; Computer programming; Consultancy in the design and development of computer hardware.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Chemicals used in industry, science and photography, as well as in agriculture, horticulture and forestry; Chemical reagents, other than for medical or veterinary purposes. Dietary supplements for humans and animals; Chemical preparations for medical or pharmaceutical purposes; Veterinary preparations; Pharmaceutical preparations. Engineering evaluations and appraisals in the fields of science and technology; Scientific and technical research; Design and development of computer hardware and software; Research and development for others; Technical project studies.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Chemicals used in industry, science and photography, as well as in agriculture, horticulture and forestry; Chemical reagents, other than for medical or veterinary purposes. Pharmaceutical preparations; Veterinary preparations; Dietary supplements for humans and animals; Chemical preparations for medical or pharmaceutical purposes. Engineering evaluations and appraisals in the fields of science and technology; Scientific and technical research; Design and development of computer hardware and software; Research and development for others; Technical project studies.
