A61K 31/4725 - Isoquinoléines non condensées, p. ex. papavérine contenant d'autres hétérocycles
A61K 31/195 - Acides carboxyliques, p. ex. acide valproïque ayant un groupe amino
A61K 31/4409 - Pyridines non condenséesLeurs dérivés hydrogénés substituées uniquement en position 4, p. ex. isoniazide, iproniazide
A61K 31/4436 - Pyridines non condenséesLeurs dérivés hydrogénés contenant d'autres systèmes hétérocycliques contenant un hétérocycle avec le soufre comme hétéro-atome du cycle
A61K 31/445 - Pipéridines non condensées, p. ex. pipérocaïne
A61K 31/4709 - Quinoléines non condensées contenant d'autres hétérocycles
A61P 25/04 - Analgésiques centraux, p. ex. opioïdes
C07D 213/68 - Un atome d'oxygène lié en position 4
C07D 213/74 - Radicaux amino ou imino substitués par des radicaux hydrocarbonés ou par des radicaux hydrocarbonés substitués
C07D 401/04 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
C07D 401/12 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 409/12 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
An extrusion device for manufacturing a hollow structure by coaxial extrusion of a plurality of media. The extrusion device has a plurality of mountings, each for a nozzle for extruding one of the media. The mountings extend in an axial direction along a central axis and are arranged coaxially, for coaxial arrangement of the nozzles in one another. At least two of the mountings follow one another in a radial direction and are mounted against one another in the radial direction by use of a bearing such that the at least two mountings can be displaced relative to one another in the axial direction in order to adjust the relative axial positions of the respective nozzles.
B29C 48/09 - Objets dont la section transversale comporte des cavités partiellement ou entièrement fermées, p. ex. tuyaux ou canaux
B29C 48/21 - Articles comprenant au moins deux composants, p. ex. couches coextrudées les composants étant des couches les couches étant jointes à leurs surfaces
B29C 48/25 - Éléments constitutifs, détails ou accessoiresOpérations auxiliaires
B29C 48/335 - Filières d’extrusion à orifices annulaires multiples disposés coaxialement, p. ex. pour fabriquer des objets tubulaires multicouches
The invention provides an apparatus and a method for generating a perfusion image, as well as a method for training an artificial neural network for use therein. The method comprises at least steps of: receiving (S100) at least one non-contrast medical diagnostic image. NCMDI (1-i), acquired from organic tissue: generating (S200), using an artificial neural network. ANN (2), trained and configured to receive input data (10) based on at least one of the received at least one non-contrast medical diagnostic image, NCMDI (1-i), based on the input data (10), at least a perfusion image (3) for the organic tissue shown in the at least one non-contrast medical diagnostic image, NCMDI (1-i); and outputting (S300) at least the generated perfusion image (3).
G01R 33/563 - Amélioration ou correction de l'image, p. ex. par des techniques de soustraction ou d'établissement de moyenne de matériaux en mouvement, p. ex. angiographie à écoulement contrasté
G06V 10/82 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant les réseaux neuronaux
G16H 30/20 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le maniement d’images médicales, p. ex. DICOM, HL7 ou PACS
4.
METHOD FOR CONDITIONING AND HYDROLYSIS OF AN EXTRUDED MEMBRANE
A method (500) for conditioning or hydrolysis of an extruded membrane is disclosed. The method (500) comprising ion exchange processes in divided electrochemical cells using a cation exchanger membrane. The method (500) includes extruding the perfluorosulfonyl fluoride membranes from perfluorosulfonyl fluoride granulate. The method (500) also includes using a pretreatment technique to increase the ionic conductivity of the extruded perfluorosulfonyl fluoride membranes before using the perfluorosulfonic acid membranes in electrolysis cells. The method (500) also includes applying a milder pretreatment technique by activating S—F bonds to execute nucleophilic exchange of the fluoride group in a reaction. The method (500) also includes hydrolyzing sulfonyl fluoride groups to sulfonic acid using triethylsilanol.
A computer-implemented method identifies an operation parameter of an industrial process as a candidate for modification so that the process can continue even of the material at the input of the process changes. In simulation instances, the computer receives representations of the material and of operation parameters and provides a representation of the would-be product. The computer classifies the instances into first and second quality classes. The computer continues by clustering—separated by parameters—the instances according to parameter attributes and according to the first and second quality classes. The computer repeats the simulation with variations that are related to significant differences, and identifies the candidate for modification.
This application provides methods and apparatuses for encoding image or video related data into a bitstream. The present disclosure may be applied in the field of artificial intelligence (AI)-based video or picture compression technologies, and in particular, to the field of neural network-based video compression technologies. A neural network (generalized difference) is applied to a signal and a predicted signal during the encoding to obtain a generalized residual. During the decoding another neural network (generalized sum) may be applied to a reconstructed generalized residual and the predicted signal to obtain a reconstructed signal.
H04N 19/20 - Procédés ou dispositions pour le codage, le décodage, la compression ou la décompression de signaux vidéo numériques utilisant le codage d'objets vidéo
H04N 19/587 - Procédés ou dispositions pour le codage, le décodage, la compression ou la décompression de signaux vidéo numériques utilisant le codage prédictif mettant en œuvre un sous-échantillonnage ou une interpolation temporels, p. ex. décimation ou interpolation subséquente d’images dans une séquence vidéo
7.
Method for Manufacturing a Component by Means of Layered Construction
The invention relates to a method for producing a component by means of layered construction, by combining a plurality of crystallites of a metallic material to form a single crystal. The single crystal is formed by thermomechanically activated successive anisotropic plastic deformation. The metallic material is heated during the construction of a new layer, with the result that the metallic material is melted in a linear region. The linear region is moved in order to construct the new layer.
C30B 13/06 - Croissance des monocristaux par fusion de zoneAffinage par fusion de zone la zone fondue ne s'étendant pas à toute la section transversale
B22F 10/28 - Fusion sur lit de poudre, p. ex. fusion sélective par laser [FSL] ou fusion par faisceau d’électrons [EBM]
The application describes a T-cell expressing a chimeric antigen receptor (‘CAR T-cell’) containing superparamagnetic iron-based particles (‘loaded CAR T-cell’) for use in treating a tumor. Said loaded CAR T-cell exhibits a reduced cytokine release upon binding to a cell of the tumor expressing an antigen being recognized by the CAR of the CAR T-cell, compared to a CAR T-cell not containing superparamagnetic iron-based particles (‘unloaded CAR T-cell’) under the same conditions. Furthermore, an in vitro method of generating a CAR T-cell containing superparamagnetic iron-based particles is described, whereby such loaded CAR T-cells are generated.
A61K 51/12 - Préparations contenant des substances radioactives utilisées pour la thérapie ou pour l'examen in vivo caractérisées par un aspect physique particulier, p. ex. émulsion, microcapsules, liposomes
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
Large-signal inductance measuring device for performing a measuring operation for measuring an inductance at an electrical energy supply line arrangement operated with a DC voltage, the large-signal inductance measuring device including: a disconnecting switch for electrically disconnecting the first conductor of the energy supply line arrangement; a first series circuit including a first capacitive arrangement and a first diode arrangement; a first measuring device for measuring a first change in voltage after the first conductor is disconnected; a second series circuit including a second capacitive arrangement and a second diode arrangement; a second measuring device for measuring a second change in voltage after the first conductor is disconnected; a third measuring device for measuring a third current on the first conductor before the first conductor is disconnected; and an evaluation device for evaluating the measured first change in voltage, the measured second change in voltage, and the measured third current.
G01R 27/26 - Mesure de l'inductance ou de la capacitanceMesure du facteur de qualité, p. ex. en utilisant la méthode par résonanceMesure de facteur de pertesMesure des constantes diélectriques
10.
METHOD FOR UPDATING RISK ANALYSIS PARAMETERS OF A TECHNICAL SYSTEM
A computer-based method for updating risk analysis parameters of a proactive risk analysis of a technical system, such as of an FMEA analysis for example. The method uses incident report data obtained during posterior operation of the technical system, compares these incident report data with data of the proactive risk analysis, and updates the said risk analysis parameters in function of said comparison.
An apparatus comprising a six-port circuit, a delay device, and a computing device, wherein the delay device is adapted to divide an input signal into a first input signal and a second input signal, to delay the first input signal by a first delay time, wherein, for example, a first delayed input signal is obtained, to delay the second input signal by a second delay time, wherein, for example, a second delayed input signal is obtained, the second delay time being different from the first delay time, wherein the delay device is adapted to output the first delayed input signal to a first input of the six-port circuit, and to output the second delayed input signal to a second input of the six-port circuit, wherein the computing device is adapted to determine a first quantity characterizing a frequency of the input signal in dependence on at least one output signal of the six-port circuit.
G01R 23/02 - Dispositions pour procéder à la mesure de fréquences, p. ex. taux de répétition d'impulsionsDispositions pour procéder à la mesure de la période d'un courant ou d'une tension
12.
IMMOBILIZATION AND MAGNETIC EXTRACTION OF PATHOGENS AND PATHOGEN COMPONENTS
Immobilization and magnetic extraction of pathogens and pathogen components The application describes a method for reducing the concentration of pathogens and/or pathogen components in an aqueous or body fluid sample. Specifically, the method relates to incubating the sample with superparamagnetic iron-based particles attached to a target binding peptide and immobilising the superparamagnetic iron-based particles with a magnetic field and thereby separating the pathogen-bound and/or pathogen component-bound superparamagnetic iron-based particles from the sample. Furthermore, the application relates to a method for identifying pathogens in an aqueous or body fluid sample a use of superparamagnetic iron-based particles for reducing the concentration of pathogens and/or pathogen components in an aqueous or body fluid sample. In addition, a use of superparamagnetic iron-based particles for identifying pathogens in an aqueous or body fluid sample is disclosed. Finally, superparamagnetic ironoxide nanoparticles (SPION's) are disclosed, wherein the SPIONs are linked to a target binding peptide. wherein the target is a pathogen, and/or a pathogen component.
G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
C02F 1/48 - Traitement de l'eau, des eaux résiduaires ou des eaux d'égout au moyen de champs magnétiques ou électriques
G01N 33/569 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour micro-organismes, p. ex. protozoaires, bactéries, virus
13.
Switchable Dense Motion Vector Field Interpolation
A sparse motion field exchanges motion information between encoder and decoder. Side information indicates a suitable interpolation approach for interpolating the motion vectors of the dense motion field different from the signaled sparse motion field motion vectors. The side information is provided on a segment basis. The segments are derived at the encoder side and the decoder side similarly, based on the reference images and the sparse motion field.
Brandenburgische Technische Universität Cottbus-Senftenberg (Allemagne)
Inventeur(s)
Müller, Ralf R.
Rosenberger, Hans
Reichenbach, Marc
Abrégé
An apparatus computing a matrix vector product of a given matrix, wherein the given matrix is represented by S submatrices, with S□1, with each submatrix representing a vertical slice of the given matrix, and with each submatrix approximated by the product of P further matrices, with P□1. Each further matrix is a sparse matrix and includes in each row a certain number of elements unequal to zero. The apparatus has S processing chains, wherein each processing chain is to receive an arbitrary vector and comprises P processing blocks. Each processing block is to multiply a block input vector and an associated further matrix by shifting the elements of the block input vector according to the values of the elements in the associated further matrix which are unequal to zero, and by combining the shifted elements of the block input vector to obtain respective elements of a block output vector.
G06F 5/01 - Procédés ou dispositions pour la conversion de données, sans modification de l'ordre ou du contenu des données maniées pour le décalage, p. ex. la justification, le changement d'échelle, la normalisation
15.
Bone Morphogenetic Protein-8B (BMP8B) as marker and therapeutic target for liver fibrosis or liver cancer
The present invention refers to BMP8B-inhibitor for use in a method of preventing and/or treating liver fibrosis and/or liver cancer, wherein the inhibitor is an oligonucleotide, an antibody or fragment thereof, a small molecule or a combination thereof. Further, the invention is directed to a method for diagnosing liver fibrosis and/or liver cancer and a kit for diagnosing fibrosis and/or cancer. The method and the kit can be used to identify a subject in need for a BMP8B-inhibitor to prevent and/or treat liver fibrosis and/or liver cancer.
C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
Provided herein is the use of a soluble form of a member of the CD83 family of proteins (sCD83) for wound healing, including hard-to-heal wounds of elderly, diabetic, or patients under immunosuppressant medication. Further provided is the therapeutic use of the sCD83 for the systemic promotion of hair growth, after physical stress/medication, disease and/or depilation by application of systemic sCD83, and cosmetic methods for skin and hair care comprising the topical application of sCD83.
A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
A61K 8/64 - ProtéinesPeptidesLeurs dérivés ou produits de dégradation
A61Q 7/00 - Préparations pour modifier la pousse des cheveux ou des poils
A61P 17/02 - Médicaments pour le traitement des troubles dermatologiques pour traiter les blessures, les ulcères, les brûlures, les cicatrices, les cheloïdes, ou similaires
17.
Crystal Growing Unit for Producing a Single Crystal
The invention relates to a crystal growing unit comprising a crucible for producing and/or enlarging a single crystal. The crystal growing unit has a first thermal insulation with a first thermal conductivity and a second thermal insulation with a second thermal conductivity. The crucible has a crucible base, a crucible side wall and a crucible cover. The crucible side wall is indirectly or directly surrounded by the first thermal insulation. The second thermal insulation is arranged indirectly or directly above the crucible cover. The second thermal conductivity is greater than the first thermal conductivity.
C30B 35/00 - Appareillages non prévus ailleurs, spécialement adaptés à la croissance, à la production ou au post-traitement de monocristaux ou de matériaux polycristallins homogènes de structure déterminée
18.
PARTICLE DISPERSION AND PROCESS FOR FORMING A PARTICLE DISPERSION
The present invention relates to a process for producing a particle dispersion comprising the steps of: a) providing a dispersion consisting of a solvent and solid core particles, b) providing a solution of a soluble, interfacially-active polymer having a molecular weight of more than 5 kDa, c) mixing said dispersion of solid core particles with said polymer solution, d) removing free polymer from the obtained mixture; wherein in step a) the solvent is selected from an organic solvent, a mixture of at least two organic solvents or a mixture of at least one organic solvent with water; wherein in step c), the amount of the soluble, interfacially-active polymer mixed with said dispersion of solid core particles exceeds the amount of polymer required to coat the surface of each of the solid core particles with a monolayer of the polymer; wherein step d) is repeated until the requirement described by the following formula is fulfilled:
The present invention relates to a process for producing a particle dispersion comprising the steps of: a) providing a dispersion consisting of a solvent and solid core particles, b) providing a solution of a soluble, interfacially-active polymer having a molecular weight of more than 5 kDa, c) mixing said dispersion of solid core particles with said polymer solution, d) removing free polymer from the obtained mixture; wherein in step a) the solvent is selected from an organic solvent, a mixture of at least two organic solvents or a mixture of at least one organic solvent with water; wherein in step c), the amount of the soluble, interfacially-active polymer mixed with said dispersion of solid core particles exceeds the amount of polymer required to coat the surface of each of the solid core particles with a monolayer of the polymer; wherein step d) is repeated until the requirement described by the following formula is fulfilled:
(STdisp−18 mN/m)/(STsolv−18 mN/m)>0.90,
The present invention relates to a process for producing a particle dispersion comprising the steps of: a) providing a dispersion consisting of a solvent and solid core particles, b) providing a solution of a soluble, interfacially-active polymer having a molecular weight of more than 5 kDa, c) mixing said dispersion of solid core particles with said polymer solution, d) removing free polymer from the obtained mixture; wherein in step a) the solvent is selected from an organic solvent, a mixture of at least two organic solvents or a mixture of at least one organic solvent with water; wherein in step c), the amount of the soluble, interfacially-active polymer mixed with said dispersion of solid core particles exceeds the amount of polymer required to coat the surface of each of the solid core particles with a monolayer of the polymer; wherein step d) is repeated until the requirement described by the following formula is fulfilled:
(STdisp−18 mN/m)/(STsolv−18 mN/m)>0.90,
with STdisp being the surface tension of the modified particle dispersion in [mN/m] and STsolv being the surface tension of the pure solvent or solvent mixture in [mN/m]; and wherein the solvent or solvent mixture contained in the dispersion of solid core particles is miscible with the solvent or solvent mixture contained in the polymer solution. The present invention also relates to a particle dispersion exhibiting a homogenous drying pattern as well as a film made thereof and the use of the non-aqueous particle dispersion.
A measuring system comprises a stand having a base plate and a vertical column fastened thereto, a stand carriage that is movable along the vertical column and having a counter bearing for placing the object, a runner that is fastened to the stand carriage and is movable relative thereto in a guided manner and has an indenter for penetrating the object, having at least one force generation actuator, at least one motion generation actuator, wherein the indenter is coupled to the stand carriage via the actuators. The measuring system further comprises a metrology frame which is fastened to the counter bearing and is supported laterally on the vertical column, a displacement measuring unit for measuring a displacement of the stand carriage and/or the runner with the indenter. The measuring system comprises a force measuring circuit and a displacement measuring circuit both being are largely configured separately from one another.
G01N 3/42 - Recherche de la dureté ou de la dureté au rebondissement en effectuant des empreintes sous une charge permanente par des dispositifs de pénétration, p. ex. sphère, pyramide
G01N 3/62 - Fabrication, étalonnage ou réparation des dispositifs utilisés dans les recherches couvertes par les sous-groupes précédents
20.
ELECTRODE STRUCTURE FOR GUIDING A CHARGED PARTICLE BEAM
An electrode structure for guiding and, for example, for splitting a beam of charged particles, for example an electron beam, along a longitudinal path has multipole electrode arrangements that are spaced apart from one another along the longitudinal path and that have DC voltage electrodes. The electrode arrangements are configured to generate static multipole fields centered around the path in transverse planes oriented perpendicular to the longitudinal path, wherein the field strengths of the static multipole fields in the transverse planes each have a local minimum at the location of the path and increase as the distance from the location of the path increases. Field directions of the static multipole fields vary periodically with a period length along the path so that the particles propagating along the path are subjected to an inhomogeneous alternating electric field due to their intrinsic movement and experience a transverse return force towards the longitudinal path on average over time.
A logic gate device comprising a probe structure having an interface contact, a first logic input for receiving a first light pulse having a first carrier-envelope phase that encodes an input state of the first logic input and a second logic input for receiving a second light pulse having a second carrier-envelope phase that encodes an input state of the second logic input. The probe structure is arranged to be irradiated by the first light pulse to generate a first current component within the probe structure that depends on the first carrier-envelope phase and to be irradiated by the second light pulse to generate a second current component within the probe structure that depends on the second carrier-envelope phase. The interface contact is arranged to output a sum current that comprises the first and second current component, wherein the sum current encodes a logic output state of a logic output.
The invention relates to dendritic cells, the NFκB signaling pathway of which has been manipulated by RNA transfection, to the manufacture thereof and to use thereof.
C12N 15/85 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules animales
A61K 35/12 - Substances provenant de mammifèresCompositions comprenant des tissus ou des cellules non spécifiésCompositions comprenant des cellules souches non embryonnairesCellules génétiquement modifiées
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
A61K 31/4409 - Pyridines non condenséesLeurs dérivés hydrogénés substituées uniquement en position 4, p. ex. isoniazide, iproniazide
A61K 31/4436 - Pyridines non condenséesLeurs dérivés hydrogénés contenant d'autres systèmes hétérocycliques contenant un hétérocycle avec le soufre comme hétéro-atome du cycle
A61K 31/444 - Pyridines non condenséesLeurs dérivés hydrogénés contenant d'autres systèmes hétérocycliques contenant un cycle à six chaînons avec l'azote comme hétéro-atome du cycle, p. ex. amrinone
A61K 31/4725 - Isoquinoléines non condensées, p. ex. papavérine contenant d'autres hétérocycles
A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]
C07D 213/73 - Radicaux amino ou imino non substitués
C07D 213/74 - Radicaux amino ou imino substitués par des radicaux hydrocarbonés ou par des radicaux hydrocarbonés substitués
C07D 401/04 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
C07D 401/12 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 409/12 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
SUPRAPARTICLE AND ADDITIVE FOR THE OPTICAL INDICATION OF HYDROGEN GAS, METHOD FOR PREPARING THE SUPRAPARTICLE(S) OR THE ADDITIVE, AND USE OF THE SUPRAPARTICLE(S) OR THE ADDITIVE
The present invention relates to a supraparticle for optically indicating hydrogen gas or elemental hydrogen. The supraparticle comprises: - a particle superstructure consisting of nanoparticles; and - substances embedded into the particle superstructure. The nanoparticles are selected from the group consisting of SiO2 nanoparticles, metal oxide nanoparticles, polymer nanoparticles, and mixtures thereof. Furthermore, the substances embedded into the particle superstructure comprise: - at least one catalytically active substance for catalyzing a dissociation of hydrogen; and - at least one redox dye. The present invention additionally relates to an additive for optically indicating hydrogen gas, the additive containing or consisting of a plurality of the supraparticles. The present invention further relates to a method for producing the supraparticle(s) or the additive and to the use of the supraparticle(s) or the additive.
G01N 21/78 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé en observant l'effet sur un réactif chimique produisant un changement de couleur
25.
METHOD FOR MANUFACTURING HIGH-FREQUENCY FUNCTIONAL STRUCTURES
The invention relates to a method of manufacturing technical radio frequency functional structures comprising the steps of providing a base body determining the shape of the functional structure and applying an electrically conductive layer to the shape-determining base body by means of wetting the base body with a dispersion containing microparticles and/or nanoparticles.
H01P 11/00 - Appareils ou procédés spécialement adaptés à la fabrication de guides d'ondes, résonateurs, lignes ou autres dispositifs du type guide d'ondes
B05D 1/18 - Procédés pour appliquer des liquides ou d'autres matériaux fluides aux surfaces par immersion
B05D 1/02 - Procédés pour appliquer des liquides ou d'autres matériaux fluides aux surfaces réalisés par pulvérisation
B05D 1/26 - Procédés pour appliquer des liquides ou d'autres matériaux fluides aux surfaces par application de liquides ou d'autres matériaux fluides, à partir d'un orifice en contact ou presque en contact avec la surface
B05D 3/02 - Traitement préalable des surfaces sur lesquelles des liquides ou d'autres matériaux fluides doivent être appliquésTraitement ultérieur des revêtements appliqués, p. ex. traitement intermédiaire d'un revêtement déjà appliqué, pour préparer les applications ultérieures de liquides ou d'autres matériaux fluides par cuisson
B05D 3/06 - Traitement préalable des surfaces sur lesquelles des liquides ou d'autres matériaux fluides doivent être appliquésTraitement ultérieur des revêtements appliqués, p. ex. traitement intermédiaire d'un revêtement déjà appliqué, pour préparer les applications ultérieures de liquides ou d'autres matériaux fluides par exposition à des rayonnements
The present disclosure relates to an apparatus and a method for providing a plurality of motion vectors related to an image coded in a bitstream, comprising obtaining a set of sample positions within the image, obtaining respective motion vectors associated with the set of sample positions, deriving an additional motion vector based on information coded in the bitstream, determining an additional sample position located within a triangle, which is formed by three sample positions of the set of sample positions, based on the respective motion vectors associated with the three sample positions, the triangle not including any other sample position of the set, adding the additional sample position to the set of sample positions, and associating the derived additional motion vector with the additional sample position. Such method and apparatus provide for an efficient motion flow compression and reconstruction enabling to recover some sample positions without signaling them in the bitstream.
H04N 19/137 - Mouvement dans une unité de codage, p. ex. différence moyenne de champs, de trames ou de blocs
H04N 19/167 - Position dans une image vidéo, p. ex. région d'intérêt [ROI]
H04N 19/132 - Échantillonnage, masquage ou troncature d’unités de codage, p. ex. ré-échantillonnage adaptatif, saut de trames, interpolation de trames ou masquage de coefficients haute fréquence de transformée
27.
INHIBITION OF TMEM16A BY BENZBROMARONE OR NICLOSAMIDE FOR TREATING POLYCYSTIC KIDNEY DISEASE AND/OR POLYCYSTIC LIVER DISEASE
The present invention relates to a compound for use in a method of treating a pathological condition selected from polycystic kidney disease, polycystic liver disease, and a combination thereof. The present invention further relates to a composition for use in a method of treating a pathological condition selected from polycystic kidney disease, polycystic liver disease, and a combination thereof.
A61K 31/343 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant des cycles à cinq chaînons avec un oxygène comme seul hétéro-atome d'un cycle, p. ex. isosorbide condensés avec un carbocycle, p. ex. coumarane, bufaralol, béfunolol, clobenfurol, amiodarone
A61K 31/167 - Amides, p. ex. acides hydroxamiques ayant des cycles aromatiques, p. ex. colchicine, aténolol, progabide ayant l'atome d'azote d'un groupe carboxamide lié directement au cycle aromatique, p. ex. lidocaïne, paracétamol
A61K 31/55 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à sept chaînons, p. ex. azélastine, pentylènetétrazole
A61K 31/436 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à six chaînons ayant l'oxygène comme hétéro-atome du cycle, p. ex. rapamycine
A61P 13/12 - Médicaments pour le traitement des troubles du système urinaire des reins
A61P 1/16 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif des troubles de la vésicule biliaire ou du foie, p. ex. protecteurs hépatiques, cholagogues, cholélitholytiques
An electron source (2) for generating an electron beam (8) having a cathode (1) and an anode (4) in the form of a graphene layer (6, 12) epitaxially grown on a silicon carbide substrate (5). The invention is suitable for monolithic preparation of a miniaturized source of a high-energy focused electron beam, including its use as an on-chip X-ray source. All components can be prepared from or on a single silicon carbide chip.
The invention refers to a composite wavelength converter (1) for an LED (100), comprising a substrate (10) and an epitaxial film (20) formed by liquid phase epitaxy on the top and bottom of the substrate (10). Furthermore, the invention refers to a method of preparation of a composite wavelength converter (1) for an LED (100). Furthermore, the invention refers to a white LED light source comprising an LED (100) and an inventive composite wavelength converter (1) mounted on a light emitting surface of the LED (100).
H01L 33/50 - DISPOSITIFS À SEMI-CONDUCTEURS NON COUVERTS PAR LA CLASSE - Détails caractérisés par les éléments du boîtier des corps semi-conducteurs Éléments de conversion de la longueur d'onde
C30B 19/04 - Croissance d'une couche épitaxiale à partir de la phase liquide en utilisant des solvants fondus, p. ex. des fondants le solvant étant un constituant du cristal
C30B 19/12 - Croissance d'une couche épitaxiale à partir de la phase liquide caractérisée par le substrat
C30B 29/28 - Oxydes complexes de formule A3Me5O12, dans laquelle A est un métal des terres rares et Me est Fe, Ga, Sc, Cr, Co ou Al, p. ex. grenats
C30B 31/04 - Procédés de diffusion ou de dopage des monocristaux ou des matériaux polycristallins homogènes de structure déterminéeAppareillages à cet effet par contact avec la substance de diffusion à l'état liquide
A method for providing transmit symbols to be transmitted by a transmitter to one or more receivers of a wireless MIMO communication system is described. The method includes receiving data to be transmitted to the one or more receivers, and obtaining the transmit symbols to be transmitted by multiplying a data vector including the data to be transmitted by a matrix, like a precoding matrix. The matrix is approximated by a plurality of matrices whose elements are positive or negative integer powers of two so that multiplying the data vector by the matrix includes a series of sub-multiplications, each of the sub-multiplications being realized only by bit shifts and additions.
The present invention relates to a powder for the preparation of three-dimensional objects comprising, or consisting of, supraparticles (8,9,10) comprising at least a first population of first primary particles, wherein the first primary particles are thermoplastic polymeric particles, wherein the first primary particles have a volume-averaged median particle diameter of from 10 to 2000 nm; wherein the primary particles are agglomerated and/or partially sintered together to form the supraparticles, and/or wherein the supraparticles have a volume-averaged median particle diameter of from 2.5 to 100 pm. The invention also relates to a method for preparing in a powder for the preparation of three-dimensional objects comprising a1) providing an at least first population of first primary particles in a first dispersion medium, thereby forming a first dispersion (1); and/or a2) providing an at least second population of second primary particles in a second dispersion medium, thereby forming a second dispersion (2); and/or a3) mixing the first dispersion and the second dispersion, thereby forming a mixture (3) of the first and second dispersion; and b) atomizing (5) the first, second or mixture of the first and second dispersion thereby forming droplets of the first, second or mixture of the first and second dispersion; and c) removing all dispersion media, preferably evaporating all dispersion media by spray drying (7), thereby obtaining supraparticles (8,9,10).
B29C 64/153 - Procédés de fabrication additive n’utilisant que des matériaux solides utilisant des couches de poudre avec jonction sélective, p. ex. par frittage ou fusion laser sélectif
B22F 1/052 - Poudres métalliques caractérisées par la dimension ou la surface spécifique des particules caractérisées par un mélange de particules de dimensions différentes ou par la distribution granulométrique des particules
B22F 1/10 - Poudres métalliques contenant des agents lubrifiants ou liantsPoudres métalliques contenant des matières organiques
The invention relates to a welding electrode for resistance welding, formed by a welding tool made of a metal, the welding tool having a contact surface that comes into contact with the workpiece to be welded. In order to avoid adhesion between the contact surface and a workpiece made, in particular of aluminum, it is suggested in the invention that the contact surface is made of diamond doped with boron.
B23K 11/30 - Caractéristiques relatives aux électrodes
B23K 11/18 - Soudage par résistance tenant compte des propriétés du métal à souder de métaux non ferreux
B23K 35/22 - Baguettes, électrodes, matériaux ou environnements utilisés pour le brasage, le soudage ou le découpage caractérisés par la composition ou la nature du matériau
The invention relates to a device for electrolysis comprising a substrate (1, 6) on which an anode formed of a first diamond layer (3) and a cathode formed of a second diamond layer (4) are provided, wherein the first (3) and second diamond layers (4) are each made of diamond doped with boron.
C25C 1/00 - Production, récupération ou affinage électrolytique des métaux par électrolyse de solutions
C02F 1/461 - Traitement de l'eau, des eaux résiduaires ou des eaux d'égout par des procédés électrochimiques par électrolyse
C02F 1/467 - Traitement de l'eau, des eaux résiduaires ou des eaux d'égout par des procédés électrochimiques par électrolyse par désinfection électrochimique
34.
Method and measuring arrangement for determining a rheological property of a fluid
In order to determine a rheological property of a fluid, the fluid is conveyed with a constant volume flow rate through a nozzle and the fluid strand thereby generated is deposited on a substrate. A relative movement takes place between the nozzle and the substrate at a forward feed velocity value. A contour of the liquid strand between the nozzle and the substrate is optically measured, and an extensional viscosity as a rheological property is deduced from knowledge of the volume flow rate, the forward feed velocity value and the contour of the fluid strand.
G01N 11/04 - Recherche des propriétés d'écoulement des matériaux, p. ex. la viscosité, la plasticitéAnalyse des matériaux en déterminant les propriétés d'écoulement en mesurant l'écoulement du matériau à travers un passage étroit, p. ex. un tube, une ouverture
G01N 11/08 - Recherche des propriétés d'écoulement des matériaux, p. ex. la viscosité, la plasticitéAnalyse des matériaux en déterminant les propriétés d'écoulement en mesurant l'écoulement du matériau à travers un passage étroit, p. ex. un tube, une ouverture en mesurant la pression nécessaire à la production d'un écoulement connu
G01N 11/00 - Recherche des propriétés d'écoulement des matériaux, p. ex. la viscosité, la plasticitéAnalyse des matériaux en déterminant les propriétés d'écoulement
35.
Apparatus for determining spatial positions of multiple audio sources
An apparatus determines a spatial position of an audio source in multi moving audio sources scenarios. The apparatus receives audio signal versions as local sound waves. The apparatus determines first and second probabilities for a direction of arrival of the audio signal version based on the audio signal versions received within a first time interval; determines third and fourth probabilities for the direction of arrival of the audio signal version based on the audio signal versions received within a second time interval; determines a first probability difference between the first and third probabilities; determines a second probability difference between the second and fourth probabilities; combines the third probability and the first probability difference to obtain an updated third probability; combines the fourth probability with the second probability difference to obtain an updated fourth probability; and determines the spatial position based on the updated third and fourth probabilities.
H04R 1/40 - Dispositions pour obtenir la fréquence désirée ou les caractéristiques directionnelles pour obtenir la caractéristique directionnelle désirée uniquement en combinant plusieurs transducteurs identiques
G01S 15/46 - Détermination indirecte des données relatives à la position
The invention relates to a device and a method for analyzing optoacoustic data, an optoacoustic system for generating and analyzing optoacoustic data and a computer program. The device for analyzing optoacoustic data according to a first aspect of the invention comprises a data processing unit configured to determine a spatial distribution of at least one first value, which relates to concentration of collagen in a tissue comprising at least one of a muscle tissue, connective tissue, organ, tendon and/or pathogenic (fibrotic) tissue, based on optoacoustic data relating to acoustic waves generated in the tissue in response to irradiating the tissue with time-varying electromagnetic radiation at two or more different irradiation wavelengths, derive at least one second value from the spatial distribution of the at least one first value, the at least one second value corresponding to or being derived from at least one distribution parameter characterizing the spatial distribution of the at least one first value within a region of interest of the spatial distribution of the at least one first value, and provide the at least one second value and/or diagnostic information derived from the at least one second value for further use, in particular for displaying the at least one second value and/or diagnostic information on a display unit.
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61K 31/573 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes substitués en position 17 bêta par une chaîne à deux atomes de carbone, p. ex. prégnane ou progestérone substitués en position 21, p. ex. cortisone, dexaméthasone, prednisone ou aldostérone
37.
METHOD OF CLASSIFYING A SAMPLE BASED ON DETERMINATION OF FGFR
The present invention relates to a method of classifying a sample of a patient that suffers from or being at risk of developing urothelial or bladder cancer, said method comprising the steps of: a) determining in said sample from said patient, the presence or absence of alteration in an FGFR gene and/or the expression level of at least one gene encoding for a receptor selected from the group consisting of FGFR1, FGFR2, FGFR3 or FGFR4, and b) classifying the sample of said patient from the outcome of step a) into one of at least two classifications, said classifications comprising good and poor prognosis for treatment with an anti-cancer agent.
C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
C12Q 1/686 - Réaction en chaine par polymérase [PCR]
The present invention relates to a method for determining in a subject's biological sample the relative proportions of papillary renal cell carcinoma (pRCC), clear cell renal cell carcinoma (ccRCC), and chromophobe renal cell carcinoma (chRCC), an array comprising capture molecules capable of specifically binding to RCC signature genes or coding sequences thereof or products encoded thereby, and the use of RCC signature genes for classifying a subject into a renal cell carcinoma (RCC) risk group and/or for determining in a subject's biological sample the relative proportions of pRCC, ccRCC, and chRCC.
C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
39.
Audio processing apparatus and method for localizing an audio source
The disclosure relates to an audio processing apparatus for localizing an audio source. The audio processing apparatus comprises a plurality of audio sensors, including a primary audio sensor and at least two secondary audio sensors, configured to detect an audio signal from a target audio source, wherein the primary audio sensor defines at least two pairs of audio sensors with the at least two secondary audio sensors; and processing circuitry configured to: determine for each pair of audio sensors a first set of likelihoods of spatial directions of the target audio source using a first localization scheme; determine a second set of likelihoods of spatial directions of the target audio source using a second localization scheme; and determine a third set of likelihoods of spatial directions of the target audio source on the basis of the first sets of likelihoods and the second set of likelihoods.
H04B 7/08 - Systèmes de diversitéSystèmes à plusieurs antennes, c.-à-d. émission ou réception utilisant plusieurs antennes utilisant plusieurs antennes indépendantes espacées à la station de réception
A method is provided for controlling a technical system using a first agent, where the first agent implements a first artificial neural network. A first input vector of the first neural network and a current state (ht) of the first neural network are converted together into a new state (ht+1) of the first neural network. From the new state (ht+1) of the first neural network a first output vector of the first neural network is generated. A second input vector representing an emotion is then fed to the first agent, with the vector being taken into consideration during the conversion of the neural network into the new state. and a second output vector (e1) representing an expected emotion of the new state (ht+1) of the first neural network is generated.
G05B 13/02 - Systèmes de commande adaptatifs, c.-à-d. systèmes se réglant eux-mêmes automatiquement pour obtenir un rendement optimal suivant un critère prédéterminé électriques
G06N 3/04 - Architecture, p. ex. topologie d'interconnexion
41.
WELDING ELECTRODE AND USE OF THE WELDING ELECTRODE
The invention relates to a welding electrode for resistance welding, formed by a welding tool made of a metal, said welding tool having a contact surface (1) that comes into contact with the workpiece (9) to be welded. In order to avoid adhesion between the contact surface (1) and a workpiece made, in particular from aluminium, it is suggested in the invention that the contact surface (1) is made of diamond doped with boron.
A method is provided for controlling a technical system using a first neural network of an agent. A first input vector and a current state (ht) of the first network are converted together into a new state (ht+1) of the first network, from which state a first output vector of the first network is generated. The first output vector of the first network is fed to a second neural network. A first output vector of the second network representing an expected reaction of the second network to the first output vector of the first network, is generated from the new state (wt+1) of the second network. The first output vector of the second network is compared to the first input vector of the first network, in order to train the first network.
The invention relates to a locating method for localizing at least one object using wave-based signals, wherein a wave field emanates from the object to be localized and the wave field emanating from the object is received by a number N of receivers, at least one measurement signal is formed in every receiver, said measurement signal being dependent on the spatial and temporal distribution of the wave field and the phase progression of said measurement signal being characteristically influenced by the signal propagation time from the object to the receiver, wherein, for position locating, phase values for each of the at least two measurement signals are taken as measured phase values, and wherein the current position (P(k)) of the object to be located at the time k is determined by a comparison of at least one linear combination of the measured phase values with at least one linear combination of the associated hypothetical phase values, which result from the transmitter-receiver distance(s), and using a recursive filter/estimator.
G01S 5/16 - Localisation par coordination de plusieurs déterminations de direction ou de ligne de positionLocalisation par coordination de plusieurs déterminations de distance utilisant des ondes électromagnétiques autres que les ondes radio
A61K 31/517 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime condensées en ortho ou en péri avec des systèmes carbocycliques, p. ex. quinazoline, périmidine
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
C07D 403/12 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 401/12 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
45.
SCD83 FOR WOUND HEALING, HAIR GROWTH, AND SKIN AND HAIR CARE
Provided herein is the use of a soluble form of a member of the CD83 family of proteins (sCD83) for wound healing, including hard-to-heal wounds of elderly-, diabetic-, or patients under immunosuppressant medication. Further provided is the therapeutic use of the sCD83 for the systemic promotion of hair growth, after physical stress/medication, disease and/or depilation by application of systemic sCD83, and cosmetic methods for skin and hair care comprising the topical application of sCD83.
A61K 8/64 - ProtéinesPeptidesLeurs dérivés ou produits de dégradation
A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
A61P 17/02 - Médicaments pour le traitement des troubles dermatologiques pour traiter les blessures, les ulcères, les brûlures, les cicatrices, les cheloïdes, ou similaires
A61P 17/14 - Médicaments pour le traitement des troubles dermatologiques pour le traitement de la calvitie ou de l'alopécie
A61Q 7/00 - Préparations pour modifier la pousse des cheveux ou des poils
A61Q 19/00 - Préparations pour les soins de la peau
46.
Methods for threshold password-hardened encryption and decryption
A Computer-implemented method is provided for encrypting data by a server in cooperation with a predetermined number of rate limiters. The method includes receiving, by the server, a user identification, and a password to be encrypted and creating a secret message, the secret message being a key suitable for use with a symmetric key encryption/decryption scheme. The method further includes generating, on the basis of a predetermined interactive cryptographic encryption protocol, a ciphertext which encrypts the user password, and the secret message using secret keys of the rate limiters of the subset, where the threshold is smaller than or equal to the number of rate limiters, and the protocol is adapted such that the server needs only to interact with a subset of the predetermined size of the number of rate limiters for decryption of the ciphertext to recover the secret message.
H04L 29/06 - Commande de la communication; Traitement de la communication caractérisés par un protocole
H04L 9/06 - Dispositions pour les communications secrètes ou protégéesProtocoles réseaux de sécurité l'appareil de chiffrement utilisant des registres à décalage ou des mémoires pour le codage par blocs, p. ex. système DES
The present invention relates to pharmaceutical compositions comprising heterocyclic diamidines and their use in the prophylaxis and/or treatment of diseases associated with fibrosis, in particular for the treatment of diseases such as systemic sclerosis (limited cutaneous scleroderma and diffuse cutaneous scleroderma), pulmonary fibrosis, hepatic cirrhosis, renal fibrosis, chronic graft-versus-host disease, Crohn's disease, arthrofibrosis, myelofibrosis, Dupuytren's disease and nephrogenic systemic fibrosis and tumours selected from mamma carcinoma, endometrial adenocarcinoma, ovarian serous tumor, lung adenocarcinoma, lung squamous cell tumor, colorectal tumor and pancreatic tumor.
An EMI suppression component includes a piezoelectric element that is configured to provide a low impedance propagation path for electromagnetic disturbances at a resonance frequency of the piezoelectric element.
H02M 1/44 - Circuits ou dispositions pour corriger les interférences électromagnétiques dans les convertisseurs ou les onduleurs
H02M 3/335 - Transformation d'une puissance d'entrée en courant continu en une puissance de sortie en courant continu avec transformation intermédiaire en courant alternatif par convertisseurs statiques utilisant des tubes à décharge avec électrode de commande ou des dispositifs à semi-conducteurs avec électrodes de commande pour produire le courant alternatif intermédiaire utilisant des dispositifs du type triode ou transistor exigeant l'application continue d'un signal de commande utilisant uniquement des dispositifs à semi-conducteurs
In a method for producing a capacitor, a dielectric structure is generated in a trench of a semiconductor substrate. The dielectric structure includes a plurality of adjacent dielectric layers having opposing material tensions.
H01L 29/92 - Condensateurs avec barrière de potentiel ou barrière de surface
H01L 21/78 - Fabrication ou traitement de dispositifs consistant en une pluralité de composants à l'état solide ou de circuits intégrés formés dans ou sur un substrat commun avec une division ultérieure du substrat en plusieurs dispositifs individuels
H01L 29/66 - Types de dispositifs semi-conducteurs
H01L 29/94 - Dispositifs à métal-isolant-semi-conducteur, p.ex. MOS
H01L 27/06 - Dispositifs consistant en une pluralité de composants semi-conducteurs ou d'autres composants à l'état solide formés dans ou sur un substrat commun comprenant des éléments de circuit passif intégrés avec au moins une barrière de potentiel ou une barrière de surface le substrat étant un corps semi-conducteur comprenant une pluralité de composants individuels dans une configuration non répétitive
Embodiments provide a terminal point of a communication system, wherein a control signal is emitted in the communication system for coordinating the participants of the communication system, wherein the control signal is transferred distributed in correspondence with a frequency hop-based occupancy of resources of the frequency band, indicated by a control signal hopping pattern, wherein the terminal point has a receiver, wherein a receive bandwidth of the receiver is smaller at least by the factor 3 than a bandwidth of the frequency hop-based occupancy of resources of the frequency band, indicated by the control signal hopping pattern, wherein the terminal point is configured to receive a reference signal, the reference signal having information on the control signal, wherein the terminal point is configured to receive the control signal based on the information on the control signal.
Embodiments provide a controller for a participant of a communication system wirelessly communicates in a frequency band used for communication by a plurality of communication systems, wherein the controller is configured to identify a network-specific channel access pattern, wherein the network-specific channel access pattern indicates a frequency hop-based and/or time hop-based occupancy of resources of the frequency band that is usable for the communication of the communication system, wherein the controller is configured to identify a relative channel access pattern, wherein the relative channel access pattern indicates, from the usable frequency hop-based and/or time hop-based occupancy of resources of the network-specific channel access pattern, an occupancy of resources that is to be used for the transfer of data of the participant.
H04W 48/12 - Distribution d'informations relatives aux restrictions d'accès ou aux accès, p. ex. distribution de données d'exploration utilisant un canal de commande descendant
H04W 72/0446 - Ressources du domaine temporel, p. ex. créneaux ou trames
H04W 72/0453 - Ressources du domaine fréquentiel, p. ex. porteuses dans des AMDF [FDMA]
A data receiver configured to receive a signal having at least two partial data packets, the data receiver being configured to estimate a state of a transmission channel, to obtain first channel state information, to demodulate a first set of received symbols from different data packets, to obtain a first set of received encoded bits, wherein the data receiver is configured to decode the first set of received encoded bits to determine, a first set of estimated encoded bits which corresponds more likely to a first set of transmitted encoded bits than the received encoded bits, and to map the first set of estimated bits to estimated transmission symbols using a mapping rule matching a transmitter-side mapping rule to obtain a first set of estimated transmission symbols, and to determine second channel state information using the first set of estimated transmission symbols.
A61K 31/381 - Composés hétérocycliques ayant le soufre comme hétéro-atome d'un cycle ayant des cycles à cinq chaînons
C07C 275/26 - Dérivés d'urée, c.-à-d. composés contenant l'un des groupes les atomes d'azote ne faisant pas partie de groupes nitro ou nitroso ayant des atomes d'azote de groupes urée liés à des atomes de carbone de cycles autres que des cycles aromatiques à six chaînons
C07D 401/12 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07C 275/24 - Dérivés d'urée, c.-à-d. composés contenant l'un des groupes les atomes d'azote ne faisant pas partie de groupes nitro ou nitroso ayant des atomes d'azote de groupes urée liés à des atomes de carbone acycliques d'un squelette carboné non saturé contenant des cycles aromatiques à six chaînons
C07D 207/452 - Composés hétérocycliques contenant des cycles à cinq chaînons, non condensés avec d'autres cycles, ne comportant qu'un atome d'azote comme unique hétéro-atome du cycle avec uniquement des atomes d'hydrogène ou de carbone liés directement à l'atome d'azote du cycle comportant trois liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques comportant deux atomes d'oxygène liés directement en positions 2 et 5 par une double liaison avec uniquement des atomes d'hydrogène ou des radicaux ne contenant que des atomes d'hydrogène et de carbone, liés directement aux autres atomes de carbone du cycle, p. ex. maléimide avec des radicaux hydrocarbonés, substitués par des hétéro-atomes, liés directement à l'atome d'azote du cycle
C07D 233/16 - Radicaux substitués par des atomes d'azote
C07D 409/12 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 333/20 - Radicaux substitués par des hétéro-atomes, autres que les halogènes, liés par des liaisons simples par des atomes d'azote
C07D 295/125 - Composés hétérocycliques contenant des cycles polyméthylène imine d'au moins cinq chaînons, des cycles aza-3 bicyclo [3.2.2] nonane, piperazine, morpholine ou thiomorpholine, ne comportant que des atomes d'hydrogène liés directement aux atomes de carbone du cycle avec des radicaux hydrocarbonés substitués liés aux atomes d'azote du cycle substitués par des atomes d'azote liés par des liaisons simples ou doubles avec les atomes d'azote du cycle et les atomes d'azote substituants liés à la même chaîne carbonée, qui n'est pas interrompue par des cycles carbocycliques
C07D 333/58 - Radicaux substitués par des atomes d'azote
Aspects of the present disclosure include conformationally restricted analogs of catecholamine type compounds (e.g., isoprenaline, adrenaline, noradrenaline) which activate β2AR with high selectivity over β1AR. The subject beta-2 selective adrenergic receptor agonist compounds may serve as bronchiodilators and find use in the treatment of a variety of bronchoconstrictive diseases and conditions. Also provided are compositions and methods for treating preterm labor. A method of treating acute asthma including administration of a subject compound to a subject in need thereof is provided. The subject method can provide for reduced undesirable side effects associated with non-selective β-adrenergic receptor agonism, such as inotropic and chronotropic effects that leads to elevated blood pressure. The compounds can also be used to prevent or treat heart failure. Kits and compositions for practicing the subject methods are also provided.
A61K 31/337 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant des cycles à quatre chaînons, p. ex. taxol
55.
Transmitter and receiver and corresponding methods
A transmitter is configured to transmit at least one signal with a pilot sequence having a plurality of pilot symbols, wherein the transmitter has a signal generator, wherein the signal generator provides the pilot sequence, wherein the signal generator provides the pilot sequence such that the pilot sequence has at least two symbol groups each having at least two pilot symbols, and the symbol groups, when evaluating a signal received by a receiver as a result of the transmission of the signal with respect to a phase, the symbol groups generate phase errors that depend on a temporal off-set between a reference point in time of the transmission of the signal by the transmitter and a value assumed and/or estimated for the evaluation for the reference point in time, said phase errors essentially mutually compensating each other across the symbol groups in the evaluation.
The present invention relates to a method for manufacturing an electronic or electrical system, the method comprising the layer-free production of at least one physical structure (101, 102) which is designed to guide electromagnetic waves, using at least one additively operating apparatus, wherein the layer-free production of the spatial, layer-free structure comprises the simultaneous or sequential application and/or removal of one or more materials in the spatial arrangement, as a result of which the electronic or electrical system is partially or completely formed. The invention further relates to a system which is manufactured in accordance with the method.
B29C 70/88 - Façonnage de matières composites, c.-à-d. de matières plastiques comprenant des renforcements, des matières de remplissage ou des parties préformées, p. ex. des inserts caractérisées principalement par des propriétés spécifiques, p. ex. électriquement conductrices ou renforcées localement
B29C 64/112 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux utilisant des gouttelettes individuelles, p. ex. de buses de jet
H05K 3/12 - Appareils ou procédés pour la fabrication de circuits imprimés dans lesquels le matériau conducteur est appliqué au support isolant de manière à former le parcours conducteur recherché utilisant la technique de l'impression pour appliquer le matériau conducteur
57.
METHODS FOR SCREENING AND IDENTIFYING AGENTS THAT INHIBIT OR MODULATE THE NUCLEAR EGRESS COMPLEX OF HERPESVIRUSES
The present invention generally provides for a novel NEC-targeted strategy for the development of antiherpesviral drugs as well as for a novel antiviral strategy targeting the viral-cellular nuclear egress complex (NEC) for a small molecule-based therapy or prophylaxis to control infections with human cytomegalovirus or other pathogenic viruses of the group of the Herpesviridae. Methods for screening agents / compounds /small molecules modulating/ inhibiting the nuclear egress complex of Herpesviridae are provided as well. Specifically novel drug targets of the viral nuclear egress complex of viruses of the Herpesviridae are provided.
Embodiments relate to a controller for a participant of a communications system, wherein the communications system communicates wirelessly in a frequency band which is used for communication by a plurality of communications systems, wherein the controller is designed to determine a network-specific channel access pattern, wherein the network-specific channel access pattern specifies a frequency- and/or time-hop-based allocation of resources of the frequency band which can be used for the communication of the communications system, wherein the controller is designed to determine a relative channel access pattern, wherein the relative channel access pattern specifies an allocation of resources, to be used for a transmission of data of the participant, from the usable frequency- and/or time-hop-based allocation of resources of the network-specific channel access pattern.
Embodiments relate to a controller for a participant of a communications system, wherein the communications system wirelessly communicates in a frequency band which is used by a plurality of communications systems for communication, wherein the controller is designed to determine a channel access pattern, wherein the channel access pattern specifies a frequency- and/or time-hop-based allocation of the frequency band which can be used for the communication of the communications system, wherein the controller is designed to determine the channel access pattern according to individual information of the communications system and according to a status of a number sequence generator for generating a number sequence or a number of a number sequence.
H04W 72/23 - Canaux de commande ou signalisation pour la gestion des ressources dans le sens descendant de la liaison sans fil, c.-à-d. en direction du terminal
60.
CD33-, CD16- and CD123-specific single chain triplebody
The present invention relates to a nucleic acid molecule encoding a chain myeloid capable of specifically binding to CD33, CD16 and CD123, wherein said nucleic molecule comprises: (a) a nucleic add molecule encoding a protein represented by SEQ ID NO:1; (b) a nucleic acid molecule represented by SEQ ID NO:2; (c) the nucleic add molecule of (b), wherein each thymine is replaced by urea; (d) a nucleic acid molecule encoding a protein having at least 98% sequence identity to the protein of (a); or (e) a nucleic add molecule that is degenerate with respect to the nucleic acid molecule of (b) or (c). The present invention further relates to a vector comprising the nucleic acid molecule of the invention, a host cell transformed or transfected with the nucleic acid molecule or the vector of the invention, as well as to a method for the production of a single chain myeloid capable of specifically binding to CD33, CD16 and CD123. Furthermore, the present invention also relates to a single chain myeloid capable of specifically binding to CD33, CD16 and CD123 encoded by the nucleic acid molecule of the invention, as well as to a composition comprising the nucleic acid molecule, the vector, the host cell and/or the single chain myeloid of the invention. Also, encompassed by the present invention are the nucleic acid molecule, the vector, the single chain myeloid and/or the composition of the invention for use in the treatment of acute myeloid leukaemia and/or myelodysplastic syndrome, as well as a method of treating acute myeloid leukaemia and/or myelodysplastic syndrome.
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
61.
Apparatus and method for calibrating measuring instruments
A method and apparatus is provided for implementing a parametric down-conversion (PDC)-based calibration comprising calibrating a measuring instrument; disposing a pinhole at a position of a light-emitting sample for which the measuring instrument needs to be calibrated; irradiating a nonlinear crystal with a light source; setting the nonlinear crystal by ensuring a phase-matching wavelength of the nonlinear crystal is set at one boundary of a desired bandwidth; acquiring one or more PDC spectrums by the measuring instrument; obtaining peak values and their corresponding wavelengths from each acquired spectrum; and obtaining a response function based on the peak values and corresponding wavelengths.
G01N 21/27 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en utilisant la détection photo-électrique
Embodiments represent a data receiver, wherein the data receiver is designed for receiving a signal, wherein the signal has at least two separate sub-data-packets, wherein the at least two separate sub-data-packets have symbols mapping coded bits resulting from a coding of a data bit string carried out for the at least two separate sub-data-packets together and introducing a redundancy, wherein the data receiver is designed to estimate a channel status of a transmission channel of the signal based on the received signal, in order to obtain first channel status information, wherein the data receiver is designed to demodulate a first set of received symbols from different sub-data-packets using the first channel status information, wherein the first set of received symbols is an actual partial quantity of the received symbols of the at least two sub-data-packets in order to obtain a first set of received coded bits, wherein the first set of received coded bits permits an inference of a first set of coded bits corresponding to the first set of received coded bits on the transmission side, with the utilisation of the transmission-side redundancy-generating coding, wherein the data receiver is designed to decode the first set of received coded bits, to determine a first set of estimated coded bits, with the utilisation of the transmission-side redundancy-generating coding, which corresponds to a first set of transmitted coded bits with a higher level of probability than the received coded bits, and to map the first set of estimated bits as estimated transmission symbols using a mapping rule corresponding to a transmission-side mapping rule in order to obtain a first set of estimated transmission symbols, wherein the data receiver is designed to determine second channel status information using the first set of estimated transmission symbols.
Embodiments provide a transfer method for wirelessly transferring data in a communication system (e.g. a sensor network or telemetry system). The data includes core data and extension data, wherein the core data is encoded and distributed in an interleaved manner to a plurality of core sub-data packets, wherein the extension data is encoded and distributed in an interleaved manner to a plurality of extension sub-data packets, wherein at least a part of the core data contained in the core sub-data packets is needed for receiving the extension data or extension data packets.
H04B 1/7143 - Dispositions pour la production de séquences de sauts
H04L 1/00 - Dispositions pour détecter ou empêcher les erreurs dans l'information reçue
H03M 13/27 - Codage, décodage ou conversion de code pour détecter ou corriger des erreursHypothèses de base sur la théorie du codageLimites de codageMéthodes d'évaluation de la probabilité d'erreurModèles de canauxSimulation ou test des codes utilisant des techniques d'entrelaçage
H03M 13/37 - Méthodes ou techniques de décodage non spécifiques à un type particulier de codage prévu dans les groupes
H03M 13/33 - Synchronisation basée sur le codage ou le décodage d'erreurs
64.
Variable sub-packet lengths for telegram splitting in networks with low power consumption
Embodiments provide a transfer method for transferring data of variable length using a fixedly specified number of sub-data packets to which the data of variable length is distributed.
A particulate material and a process for the production thereof are provided, which particulate material comprises zeolitic particles having a crystalline structure, which contain as the main component a zeolite material having a zeolitic framework structure formed from Si, O and optionally Al, and/or a zeolite-like material having a zeolitic framework structure which is formed not only from Si, O and optionally Al, wherein the zeolitic particles are in the form of essentially spherical particles with nanometer dimensions.
B01J 37/00 - Procédés de préparation des catalyseurs, en généralProcédés d'activation des catalyseurs, en général
B01J 35/10 - Catalyseurs caractérisés par leur forme ou leurs propriétés physiques, en général solides caractérisés par leurs propriétés de surface ou leur porosité
B01J 35/02 - Catalyseurs caractérisés par leur forme ou leurs propriétés physiques, en général solides
C01B 39/40 - Type ZSM-5 utilisant au moins un agent structurant organique
B01J 29/03 - Catalyseurs contenant des tamis moléculaires n'ayant pas de propriétés d'échangeurs de base
C01B 39/04 - Zéolites aluminosilicates cristallinesLeurs composés isomorphesLeur préparation directeLeur préparation à partir d'un mélange réactionnel contenant une zéolite cristalline d'un autre type, ou à partir de réactants préformésLeur post-traitement utilisant au moins un agent structurant organique, p. ex. un composé d'ammonium quaternaire ionique ou un composé aminé
B01J 20/28 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtrationAbsorbants ou adsorbants pour la chromatographieProcédés pour leur préparation, régénération ou réactivation caractérisées par leur forme ou leurs propriétés physiques
B01J 20/30 - Procédés de préparation, de régénération ou de réactivation
C07C 275/26 - Dérivés d'urée, c.-à-d. composés contenant l'un des groupes les atomes d'azote ne faisant pas partie de groupes nitro ou nitroso ayant des atomes d'azote de groupes urée liés à des atomes de carbone de cycles autres que des cycles aromatiques à six chaînons
A61K 31/381 - Composés hétérocycliques ayant le soufre comme hétéro-atome d'un cycle ayant des cycles à cinq chaînons
C07D 401/12 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07C 275/24 - Dérivés d'urée, c.-à-d. composés contenant l'un des groupes les atomes d'azote ne faisant pas partie de groupes nitro ou nitroso ayant des atomes d'azote de groupes urée liés à des atomes de carbone acycliques d'un squelette carboné non saturé contenant des cycles aromatiques à six chaînons
C07D 207/452 - Composés hétérocycliques contenant des cycles à cinq chaînons, non condensés avec d'autres cycles, ne comportant qu'un atome d'azote comme unique hétéro-atome du cycle avec uniquement des atomes d'hydrogène ou de carbone liés directement à l'atome d'azote du cycle comportant trois liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques comportant deux atomes d'oxygène liés directement en positions 2 et 5 par une double liaison avec uniquement des atomes d'hydrogène ou des radicaux ne contenant que des atomes d'hydrogène et de carbone, liés directement aux autres atomes de carbone du cycle, p. ex. maléimide avec des radicaux hydrocarbonés, substitués par des hétéro-atomes, liés directement à l'atome d'azote du cycle
C07D 233/16 - Radicaux substitués par des atomes d'azote
C07D 409/12 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 333/20 - Radicaux substitués par des hétéro-atomes, autres que les halogènes, liés par des liaisons simples par des atomes d'azote
C07D 295/125 - Composés hétérocycliques contenant des cycles polyméthylène imine d'au moins cinq chaînons, des cycles aza-3 bicyclo [3.2.2] nonane, piperazine, morpholine ou thiomorpholine, ne comportant que des atomes d'hydrogène liés directement aux atomes de carbone du cycle avec des radicaux hydrocarbonés substitués liés aux atomes d'azote du cycle substitués par des atomes d'azote liés par des liaisons simples ou doubles avec les atomes d'azote du cycle et les atomes d'azote substituants liés à la même chaîne carbonée, qui n'est pas interrompue par des cycles carbocycliques
C07D 333/58 - Radicaux substitués par des atomes d'azote
A data transmitter is provided, having: a generator for generating transmission data packets, configured to split a first data packet into at least three transmission data packets, each of the transmission packets being shorter than the first data packet, the generator being configured to channel-encode the at least three transmission packets such that only a portion thereof is required for decoding the first data packet; a transmission element for transmitting data packets, configured to transmit the at least three transmission packets in a frequency channel via a communications channel with a time gap; a monitor element for monitoring the frequency channel, configured to recognize an interference or transmission of a further data transmitter in the frequency channel; the transmission element being configured not to transmit via the communications channel a packet, waiting for transmission, of the at least three transmission packets if an interference or transmission from a further data transmitter is recognized by the monitor element at the time of transmitting the transmission data packet.
What is described is an Radio Frequency Identification (RFID) tag configured for communicating with an Radio Frequency Identification (RFID) reader, wherein the RFID tag is configured to receive a query command from the RFID reader, to measure a duration of a TRcal signal comprised by the query command, and to determine an individual Backscatter Link Frequency for communicating with the RFID reader based on the measured duration of the TRcal signal. The invention also refers to an RFID reader and to a corresponding method.
G06K 19/077 - Détails de structure, p. ex. montage de circuits dans le support
G06K 7/10 - Méthodes ou dispositions pour la lecture de supports d'enregistrement par radiation électromagnétique, p. ex. lecture optiqueMéthodes ou dispositions pour la lecture de supports d'enregistrement par radiation corpusculaire
69.
Method and apparatus for the detection of bacteria
The present invention relates to a fast, simple and very sensitive method for the detection of bacteria, comprising the steps of providing one or more suspensions each comprising at least one species of labeled test bacteriophages which specifically bind to a bacterial species to be detected; adding a sample to be tested for the presence of at least one bacterial species to be detected to the one or more suspensions; filtering the reaction mixture; detecting bacteria-bacteriophages-complexes on the surface of the filter in the retentate, provided that at least one bacterial species to be detected is present, wherein the complexes consist of bacteria of the at least one bacterial species to be detected and test bacteriophages of the at least one species of test bacteriophages bound thereto; detecting unbound test bacteriophages in the filtrate; processor-aided processing of received detection signals and output of detection results.
C12Q 1/04 - Détermination de la présence ou du type de micro-organismeEmploi de milieux sélectifs pour tester des antibiotiques ou des bactéricidesCompositions à cet effet contenant un indicateur chimique
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
G01N 33/569 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour micro-organismes, p. ex. protozoaires, bactéries, virus
70.
TRANSMITTER AND RECEIVER AND CORRESPONDING METHODS
The invention relates to a transmitter (1) which is configured in such a way that it transmits signals having a respective pilot sequence with multiple pilot sequence symbols, wherein the transmitter (1) has a signal generator (2), wherein the signal generator (2) is configured in such a way that it provides the pilot sequence based on a basic sequence having multiple basic sequence symbols, wherein the signal generator (2) provides the pilot sequence symbols based on the basic sequence symbol that is successively repeated (R-1) times, and wherein R is a natural number greater than or equal to two, wherein the basic sequence is configured in such a way that a correlation of the pilot sequence with a transmission signal formed by the pilot sequence has a primary maximum that is as narrow as possible and/or secondary maximums that are as small as possible.
The invention relates to a transmitter (1) which is configured in such a way that it transmits at least one signal having a pilot sequence with multiple pilot symbols, wherein the transmitter (1) has a signal generator (2), wherein the signal generator (2) provides the pilot sequence, wherein the signal generator (2) provides the pilot sequence in such a way that the pilot sequence has at least two symbol groups with a respective at least two pilot symbols, and wherein, with an evaluation of a signal received by a receiver (10) after the transmission of the signal, in relation to a phase of a time offset between a reference time of the transmission of the signal by the transmitter (1) and a value that is assumed and/or estimated for the reference time for the evaluation, the symbol groups generate corresponding phase errors, which, during the evaluation, together substantially offset one another across the symbol groups.
The present invention is directed to compounds, tautomers, stereoisomers, and chemically modified compounds thereof, and their use in preventing and/or treating tumors of metastasis and/or cartilage defect, and to a pharmaceutical composition comprising such compound.
A61K 31/4184 - 1,3-Diazoles condensés avec des carbocycles, p. ex. benzimidazoles
A61P 35/04 - Agents anticancéreux spécifiques pour le traitement des métastases
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
A61K 31/138 - Aryloxyalkylamines, p. ex. propranolol, tamoxifène, phénoxybenzamine
A61K 31/341 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant des cycles à cinq chaînons avec un oxygène comme seul hétéro-atome d'un cycle, p. ex. isosorbide non condensés avec un autre cycle, p. ex. ranitidine, furosémide, bufétolol, muscarine
A61K 31/496 - Pipérazines non condensées contenant d'autres hétérocycles, p. ex. rifampine, thiothixène ou sparfloxacine
A61K 31/497 - Pyrazines non condensées contenant d'autres hétérocycles
A61K 31/505 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime
A61K 31/513 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime ayant des groupes oxo liés directement à l'hétérocycle, p. ex. cytosine
A61K 31/519 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime condensées en ortho ou en péri avec des hétérocycles
A61K 31/53 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec trois azote comme seuls hétéro-atomes d'un cycle, p. ex. chlorazanil, mélamine
A61K 31/435 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle
A61K 31/381 - Composés hétérocycliques ayant le soufre comme hétéro-atome d'un cycle ayant des cycles à cinq chaînons
A61K 31/4985 - Pyrazines ou pipérazines condensées en ortho ou en péri avec des systèmes hétérocycliques
A61K 31/517 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime condensées en ortho ou en péri avec des systèmes carbocycliques, p. ex. quinazoline, périmidine
A61K 31/197 - Acides carboxyliques, p. ex. acide valproïque ayant un groupe amino les groupes amino et carboxyle étant liés à la même chaîne carbone acyclique, p. ex. acide gamma-aminobutyrique [GABA], bêta-alanine, acide epsilon-aminocaproïque ou acide pantothénique
A61K 31/40 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p. ex. sulpiride, succinimide, tolmétine, buflomédil
A61K 31/4025 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p. ex. sulpiride, succinimide, tolmétine, buflomédil non condensés et contenant d'autres hétérocycles, p. ex. cromakalim
A61K 31/4152 - 1,2-Diazoles ayant des groupes oxo liés directement à l'hétérocycle, p. ex. antipyrine, phénylbutazone, sulfinpyrazone
A61K 31/4402 - Pyridines non condenséesLeurs dérivés hydrogénés substituées uniquement en position 2, p. ex. phéniramine, bisacodyl
A61K 31/4453 - Pipéridines non condensées, p. ex. pipérocaïne substituées uniquement en position 1, p. ex. propipocaïne, dipérodone
A61K 31/5377 - 1,4-Oxazines, p. ex. morpholine non condensées et contenant d'autres hétérocycles, p. ex. timolol
A61K 31/55 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à sept chaînons, p. ex. azélastine, pentylènetétrazole
73.
A CD33-, CD16- AND CD123-SPECIFIC SINGLE CHAIN TRIPLEBODY
The present invention relates to a nucleic acid molecule encoding a single chain triplebody capable of specifically binding to CD33, CD16 and CD123, wherein said nucleic acid molecule comprises: (a) a nucleic acid molecule encoding a protein represented by SEQ ID NO:1; (b) a nucleic acid molecule represented by SEQ ID NO:2; (c) the nucleic acid molecule of (b), wherein each thymine is replaced by uracil; (d) a nucleic acid molecule encoding a protein having at least 98% sequence identity to the protein of (a); or (e) a nucleic acid molecule that is degenerate with respect to the nucleic acid molecule of (b) or (c). The present invention further relates to a vector comprising the nucleic acid molecule of the invention, a host cell transformed or transfected with the nucleic acid molecule or the vector of the invention, as well as to a method for the production of a single chain triplebody capable of specifically binding to CD33, CD16 and CD123. Furthermore, the present invention also relates to a single chain triplebody capable of specifically binding to CD33, CD16 and CD123 encoded by the nucleic acid molecule of the invention, as well as to a composition comprising the nucleic acid molecule, the vector, the host cell and/or the single chain triplebody of the invention. Also encompassed by the present invention are the nucleic acid molecule, the vector, the single chain triplebody and/or the composition of the invention for use in the treatment of acute myeloid leukaemia and/or myelodysplastic syndrome, as well as a method of treating acute myeloid leukaemia and/or myelodysplastic syndrome.
A61P 35/02 - Agents anticancéreux spécifiques pour le traitement de la leucémie
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
Exemplary embodiments provide a transmission method for transmitting data of variable length using a fixedly predefined number of data sub-packets, into which the data of variable length is split.
Exemplary embodiments provide a transmission method for the wireless transmission of data in a communications system (e.g. a sensor network or telemetry system). The method comprises the step of transmitting the data using at least two time hopping patterns and/or frequency hopping patterns, wherein a second pattern of the at least two patterns is a time- and/or frequency-shifted version of a first pattern of the at least two patterns.
Exemplary embodiments provide a transmission method for the wireless transmission of data in a communications system (e.g. a sensor network or telemetry system). The data comprises core data and additional data, the core data being split in encoded and interleaved form into a plurality of core data sub-packets and the additional data being split in encoded and interleaved form into a plurality of additional data sub-packets, wherein at least some of the core data contained in the core data sub-packets is required for the receipt of the additional data or additional data packets.
H03M 13/27 - Codage, décodage ou conversion de code pour détecter ou corriger des erreursHypothèses de base sur la théorie du codageLimites de codageMéthodes d'évaluation de la probabilité d'erreurModèles de canauxSimulation ou test des codes utilisant des techniques d'entrelaçage
H04L 1/00 - Dispositions pour détecter ou empêcher les erreurs dans l'information reçue
77.
APPARATUS AND METHOD FOR CALIBRATING MEASURING INSTRUMENTS
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN E.V. (Allemagne)
Inventeur(s)
Manceau, Mathieu
Boyd, Robert W.
Leuchs, Gerd
Chekhova, Maria V.
Lemieux, Samuel
Abrégé
A method and apparatus is provided for implementing a parametric down-conversion (PDC)-based calibration comprising calibrating a measuring instrument; disposing a pinhole at a position of a light-emitting sample for which the measuring instrument needs to be calibrated; irradiating a nonlinear crystal with a light source; setting the nonlinear crystal by ensuring a phase-matching wavelength of the nonlinear crystal is set at one boundary of a desired bandwidth; acquiring one or more PDC spectrums by the measuring instrument; obtaining peak values and their corresponding wavelengths from each acquired spectrum; and obtaining a response function based on the peak values and corresponding wavelengths.
Embodiments relate to a data receiver with a device for receiving sub-data packets, a device for ascertaining a phase difference, and a device for ascertaining a distance difference. The device for receiving sub-data packets is designed to receive at least two sub-data packets from a data transmitter and to combine the at least two sub-data packets in order to obtain a data packet which is transmitted in a divided state into the at least two sub-data packets by the data transmitter. Each of the at least two sub-data packets is shorter than the data packet. The device for receiving sub-data packets is designed to receive the at least two sub-data packets on at least two different carrier frequencies. The device for ascertaining a phase difference is designed to ascertain a phase difference between the at least two sub-data packets, said phase difference being caused by the at least two different carrier frequencies and the path delay. The device for ascertaining a distance difference between the data receiver and the data transmitter is designed to ascertain the distance difference on the basis of the ascertained phase difference between the at least two sub-data packets.
G01S 13/84 - Systèmes utilisant la reradiation d'ondes radio, p. ex. du type radar secondaireSystèmes analogues dans lesquels des signaux de type continu sont transmis pour la détermination de distance par mesure de phase
G01S 17/08 - Systèmes déterminant les données relatives à la position d'une cible pour mesurer la distance uniquement
H04W 64/00 - Localisation d'utilisateurs ou de terminaux pour la gestion du réseau, p. ex. gestion de la mobilité
A topologically-protected traveling-wave amplifier includes resonators arranged in a two-dimensional array defining a periphery including a first edge. An output line is coupled to an output resonator disposed along the first edge spaced from an input resonator coupled to an output line. A synthetic gauge field generator associated with the resonators provides a topologically-protected edge state corresponding to propagation along the periphery in a propagation direction from the input resonator along the first edge to the output resonator. A parametric driving element creates pairs of photons in the edge state and amplifies a signal propagating along the first edge in the propagation direction. A signal incident from the input line propagates in the propagation direction along the first edge while being amplified and is detected at the output line as an amplified signal. A signal incident from the output line is attenuated before emerging at the input resonator.
H03F 1/56 - Modifications des impédances d'entrée ou de sortie, non prévues ailleurs
H03F 7/02 - Amplificateurs paramétriques utilisant un élément à inductance variableAmplificateurs paramétriques utilisant un élément à perméabilité variable
H03F 3/20 - Amplificateurs de puissance, p. ex. amplificateurs de classe B, amplificateur de classe C
H03F 3/213 - Amplificateurs de puissance, p. ex. amplificateurs de classe B, amplificateur de classe C comportant uniquement des dispositifs à semi-conducteurs dans des circuits intégrés
H03F 3/189 - Amplificateurs à haute fréquence, p. ex. amplificateurs radiofréquence
H03F 19/00 - Amplificateurs utilisant les effets de supraconductivité
The invention relates to a circulatory assistance device (22) for a heart of a living being, comprising a cuff for periodically applying pressure to the heart (10) by means of at least one dielectric elastomer membrane which, by means of a control device (30), can be controlled in synchronization with a cardiac beat in order to convey blood in pulses, wherein the cuff is designed to be pulled over the outside of the heart (10) and for this purpose has an inner shape that is adapted to the outer contour of the heart (10) at least in the region outside the ventricles, wherein the cuff is composed of an outer contraction layer (24) and an inner padding layer (26) which is filled with an incompressible liquid and has at least one outlet valve (28) which is closed in a normal state and opened in an emergency state.
A61M 60/148 - Pompes ou dispositifs de pompage implantables, c.-à-d. que le sang est pompé à l’intérieur du corps du patient implantables par, dans, à l’intérieur, en ligne, se ramifiant dans ou autour d’un vaisseau sanguin en ligne avec un vaisseau sanguin par résection ou techniques analogues, p. ex. dispositifs permanents d’assistance cardiaque endovasculaire
A61M 60/268 - Pompes pour le sang à déplacement positif comportant un élément de déplacement agissant directement sur le sang l’élément de déplacement étant souple, p. ex. membranes, diaphragmes ou vessies
A61M 60/424 - Détails concernant l’entraînement pour les pompes pour le sang à déplacement positif
81.
DIAGNOSIS, TREATMENT AND PREVENTION OF NEUROTENSIN RECEPTOR-RELATED CONDITIONS
The present invention describes a compound of formula (I) which can be used in the diagnosis, treatment or prevention of neurotensin receptor-related conditions such as tumors and hematological malignancies.
C07D 403/14 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant au moins trois hétérocycles
C07F 5/00 - Composés contenant des éléments des groupes 3 ou 13 du tableau périodique
82.
Apparatus and method for driving an array of loudspeakers
A local wave field synthesis apparatus, which includes a determination module for determining desired sound pressures and desired particle velocity vectors at a plurality of control points, a computation module for computing sound pressures and particle velocity vectors at the plurality of control points based on a set of filter parameters, an optimization module for computing an optimum set of filter parameters by jointly optimizing computed sound pressures towards the desired sound pressures and computed particle velocity vectors towards the desired particle velocity vectors, and a generator module for generating the drive signals based on the optimum set of filter parameters, wherein the plurality of control points are located on one or more contours around the one or more audio zones.
Embodiments provide a receiver comprising a receiving unit and a synchronization unit. The receiving unit is configured to receive a data packet comprising a pilot sequence. The synchronization unit is configured to separately correlate the pilot sequence with at least two partial reference sequences corresponding to a reference sequence for the pilot sequence of the data packet, in order to obtain a partial correlation result for each of the at least two partial reference sequences, wherein the synchronization unit is configured to non-coherently add the partial correlation results in order to obtain a coarse correlation result for the data packet.
A data transmitter generates transmission data packets, configured to split a first data packet into at least three transmission data packets that are each shorter than the first data packet. The transmission data packets are channel-encoded such that only a portion of the transmission data packets is required for decoding the first data packet. Means for transmitting data packets transmits the data packets in a frequency channel via a communications channel with a time gap, and means for monitoring the frequency channel recognizes an interference or transmission of a further data transmitter in the frequency channel. The means for transmitting is configured not to transmit, transmit only partly or at a later time via the communications channel a transmission data packet, waiting for transmission, if an interference or transmission from a further data transmitter is recognized by the means for monitoring at the time of transmitting the transmission data packet.
Embodiments provide a transmitter, configured to operate in a mobile communication system according to a mobile communication standard (e.g., 3GPP), wherein resources of the communication system are divided into resources elements. The transmitter is configured to transmit an additional telegram by separating the telegram into a plurality of data packets, each of the data packets being shorter than the telegram, and transmitting each of the data packets respectively in one of the resource elements.
The invention relates to a zeolitic material comprising zeolitic monocrystals, each of which has a pore system encompassing at least one micropore system and at least one macropore system, and to a method for producing a zeolitic material of said type. In said method, porous oxide particles are converted into the zeolitic material in the presence of an organic template and steam.
C01B 39/40 - Type ZSM-5 utilisant au moins un agent structurant organique
C01B 39/48 - Autres types caractérisés par leur diagramme de diffraction des rayons X et par leur composition définie utilisant au moins un agent structurant organique
B01J 29/40 - Zéolites aluminosilicates cristallinesLeurs composés isomorphes du type pentasil, p. ex. types ZSM-5, ZSM-8 ou ZSM-11
C01B 37/02 - Polymorphes de silice cristallins, p. ex. silicalites
C01B 39/04 - Zéolites aluminosilicates cristallinesLeurs composés isomorphesLeur préparation directeLeur préparation à partir d'un mélange réactionnel contenant une zéolite cristalline d'un autre type, ou à partir de réactants préformésLeur post-traitement utilisant au moins un agent structurant organique, p. ex. un composé d'ammonium quaternaire ionique ou un composé aminé
C01B 39/08 - Préparation de zéolites isomorphes caractérisée par les mesures prises pour le remplacement des atomes d'aluminium ou de silicium dans la charpente du réseau par des atomes d'autres éléments les atomes d'aluminium étant entièrement remplacés
C01B 39/12 - Préparation de zéolites isomorphes caractérisée par les mesures prises pour le remplacement des atomes d'aluminium ou de silicium dans la charpente du réseau par des atomes d'autres éléments les atomes de remplacement étant des atomes de bore
C01B 39/54 - Phosphates, p. ex. composés APO ou SAPO
C30B 7/10 - Croissance des monocristaux à partir de solutions en utilisant des solvants liquides à la température ordinaire, p. ex. à partir de solutions aqueuses par application d'une pression, p. ex. procédés hydrothermiques
An RFID reader includes a transmitter, a receiver, and an evaluator. The receiver receives signals from RFID tags within a given number of slots of a time frame with a given frame size and provides a number of successful slots and a number of collided slots. The evaluator sets a modified frame size based on an estimated number of RFID tags which is determined based on the frame size, the number of successful slots, and the number of collided slots. The invention also refers to a corresponding method.
G06K 7/10 - Méthodes ou dispositions pour la lecture de supports d'enregistrement par radiation électromagnétique, p. ex. lecture optiqueMéthodes ou dispositions pour la lecture de supports d'enregistrement par radiation corpusculaire
H04B 7/00 - Systèmes de transmission radio, c.-à-d. utilisant un champ de rayonnement
H04Q 5/22 - Dispositifs de sélection dans lesquels plusieurs postes d’abonnés sont connectés par la même ligne au central avec connexion indirecte, c.-à-d. à travers un centre de commutation subordonné le centre subordonné ne permettant pas une interconnexion d'abonnés reliés à ce centre
88.
Method and apparatus for motion correction and image enhancement for optical coherence tomography
Images of an object, such as OCT scans of a human eye, can include distortions and data gaps due to relative motion of the object and the image acquisition device. Methods and systems for correction of such distortions and data gaps are described herein. Motion-corrected data is arrived at by applying three-dimensional transforms to input three-dimensional data sets that represent at least partially overlapping regions of the imaged object. The three dimensional transforms are computed based on an objective function that accounts for similarity between the transformed three-dimensional data sets and the estimated motion of the object relative to an imaging instrument. Methods and systems described herein advantageously eliminate the need for postulated assumptions and reliance on landmarks and are capable of filling data gaps, thereby producing high quality, undistorted images of objects subject to movement during imaging. Multiple motion-corrected data sets can be merged or combined to produce a data set with improved image quality.
A61B 3/10 - Appareils pour l'examen optique des yeuxAppareils pour l'examen clinique des yeux du type à mesure objective, c.-à-d. instruments pour l'examen des yeux indépendamment des perceptions ou des réactions du patient
A61B 3/00 - Appareils pour l'examen optique des yeuxAppareils pour l'examen clinique des yeux
G06T 7/246 - Analyse du mouvement utilisant des procédés basés sur les caractéristiques, p. ex. le suivi des coins ou des segments
The invention relates to an electron beam splitter (1) comprising a multi-pole electrode arrangement with a high-frequency alternating current voltage (5), which extends along a specified path (6) from an inlet side (9) to an outlet side (10), wherein the electrode arrangement (5) generates on the inlet side (9) with a first number of electrodes (7) impacted by the voltage a first oscillating electric field (61), which forms on a transversal plane a single local confinement minimum (62) in a time-averaged manner, and wherein the electrode arrangement (5) generates at least on the outlet side (10) with a second number of voltage-impacted electrodes (7) a second oscillating electric field (65), which forms at least two local confinement minimums (66, 67) in a time averaged manner.
The invention relates to methods for the intra-amniotic administration of EDA agonists, in particular EDI200. Use of the methods described allow for the design of targeted therapeutic dosing and administration regimens in order to correct or alter abnormal phenotypes associated with ectodermal dysplasias, in particular, XLHED.
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
In a method for producing a capacitor, a dielectric structure is generated in a trench of a semiconductor substrate. The dielectric structure includes a plurality of adjacent dielectric layers having opposing material tensions.
H01L 21/283 - Dépôt de matériaux conducteurs ou isolants pour les électrodes
H01L 21/78 - Fabrication ou traitement de dispositifs consistant en une pluralité de composants à l'état solide ou de circuits intégrés formés dans ou sur un substrat commun avec une division ultérieure du substrat en plusieurs dispositifs individuels
H01L 29/66 - Types de dispositifs semi-conducteurs
H01L 29/94 - Dispositifs à métal-isolant-semi-conducteur, p.ex. MOS
H01L 27/06 - Dispositifs consistant en une pluralité de composants semi-conducteurs ou d'autres composants à l'état solide formés dans ou sur un substrat commun comprenant des éléments de circuit passif intégrés avec au moins une barrière de potentiel ou une barrière de surface le substrat étant un corps semi-conducteur comprenant une pluralité de composants individuels dans une configuration non répétitive
92.
Method and device for joining a plurality of individual digital images to form a total image
In a device and a corresponding method for joining a plurality of individual digital images to form a total image, a plurality of features is determined in a first individual image by means of a selection unit using a feature-based algorithm and then tracked in a second individual image by means of a tracking unit. A transformation matrix, with which the individual images are joined in an output unit to form the total image, is calculated from the determined feature correspondences in a transformation unit. The individual images can be joined in real time and with a high degree of accuracy by means of the feature-based algorithm in combination with a robust algorithm to calculate the transformation matrix.
The present invention relates to a method for in vitro detection and/or monitoring of a disease in a sample, based on measurement of enzymatic activity of proteases activated and secreted upon disease development, to modified peptides used for the enzymatic detection of the proteases, the use of the peptides, a kit comprising such peptides and the use of ADAM-protease activity as a surrogate marker for disease burden and activity in infectious, inflammatory, and malignant diseases, such as HIV infection and melanoma.
C12Q 1/37 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une hydrolase faisant intervenir une peptidase ou une protéinase
G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer
C07K 7/06 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 5 à 11 amino-acides
G01N 33/542 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec formation d'un complexe immunologique en phase liquide avec inhibition stérique ou modification du signal, p. ex. extinction de fluorescence
G01N 33/569 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour micro-organismes, p. ex. protozoaires, bactéries, virus
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
94.
Method and apparatus for spatially resolved diagnosis
A method and device for diagnosing an electrical condition of a spatially extended hardware component in a spatially resolved manner via interference between pulses fed into the component by a signal generator. The method includes: feeding at least two pulses into the component offset by a pulse interval; detecting the interfered pulses and echoes via an analysis unit; varying the pulse interval for the spatially resolved scanning of the hardware component along its length; repeating the steps until the component has been scanned at least in some sections; and analyzing the detected interfered pulses in the analysis unit. The device includes at least one signal generator connected to the component and to an analysis unit to generate the pulses, wherein local energy losses are mathematically determined over the length of the component on the basis of a plurality of interference voltage waveforms and voltage waveforms induced by the pulses.
G01R 31/00 - Dispositions pour tester les propriétés électriquesDispositions pour la localisation des pannes électriquesDispositions pour tests électriques caractérisées par ce qui est testé, non prévues ailleurs
G01R 31/02 - Essai des appareils, des lignes ou des composants électriques pour y déceler la présence de courts-circuits, de discontinuités, de fuites ou de connexions incorrectes de lignes
G01R 31/11 - Localisation de défauts dans les câbles, les lignes de transmission ou les réseaux en utilisant des méthodes de réflexion d'impulsion
G01R 31/08 - Localisation de défauts dans les câbles, les lignes de transmission ou les réseaux
The invention relates to a filter material which is used, in particular in filters or as a filter for treating and/or purifying gas, in particular for clean room environments. The filter material comprises at least one activated carbon, in particular with reactive and/or catalytic finishing and the activated carbon is present in the form of discrete activated carbon particles, preferably in a spherical and/or grain form. The activated carbon comprises and/or is provided with at least one metal component which contains at least one metal-containing ionic liquid (IL), containing in particular metal ions, preferably based on a metal compound.
B01J 20/22 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtrationAbsorbants ou adsorbants pour la chromatographieProcédés pour leur préparation, régénération ou réactivation contenant une substance organique
B01J 20/20 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtrationAbsorbants ou adsorbants pour la chromatographieProcédés pour leur préparation, régénération ou réactivation contenant une substance inorganique contenant du carbone libreCompositions absorbantes ou adsorbantes solides ou compositions facilitant la filtrationAbsorbants ou adsorbants pour la chromatographieProcédés pour leur préparation, régénération ou réactivation contenant une substance inorganique contenant du carbone obtenu par des procédés de carbonisation
B01D 53/02 - Séparation de gaz ou de vapeursRécupération de vapeurs de solvants volatils dans les gazÉpuration chimique ou biologique des gaz résiduaires, p. ex. gaz d'échappement des moteurs à combustion, fumées, vapeurs, gaz de combustion ou aérosols par adsorption, p. ex. chromatographie préparatoire en phase gazeuse
B01J 20/28 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtrationAbsorbants ou adsorbants pour la chromatographieProcédés pour leur préparation, régénération ou réactivation caractérisées par leur forme ou leurs propriétés physiques
B01D 53/04 - Séparation de gaz ou de vapeursRécupération de vapeurs de solvants volatils dans les gazÉpuration chimique ou biologique des gaz résiduaires, p. ex. gaz d'échappement des moteurs à combustion, fumées, vapeurs, gaz de combustion ou aérosols par adsorption, p. ex. chromatographie préparatoire en phase gazeuse avec adsorbants fixes
96.
METHOD FOR IN VITRO DETECTION AND MONITORING OF A DISEASE BY MEASURING DISEASE-ASSOCIATED PROTEASE ACTIVITY IN EXTRACELLULAR VESICLES
The present invention relates to a method for in vitro detection and/or monitoring of a disease in a sample, based on measurement of enzymatic activity of proteases activated and secreted upon disease development, to modified peptides used for the enzymatic detection of the proteases, the use of the peptides, a kit comprising such peptides and the use of ADAM-protease activity as a surrogate marker for disease burden and activity in infectious, inflammatory, and malignant diseases, such as HIV infection and melanoma.
C12Q 1/37 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une hydrolase faisant intervenir une peptidase ou une protéinase
G01N 33/542 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec formation d'un complexe immunologique en phase liquide avec inhibition stérique ou modification du signal, p. ex. extinction de fluorescence
G01N 33/569 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour micro-organismes, p. ex. protozoaires, bactéries, virus
G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
The invention relates to dendritic cells, the NFκB signaling pathway of which has been manipulated by RNA transfection, to the manufacture thereof and to use thereof.
C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p. ex. lignées cellulairesTissusLeur culture ou conservationMilieux de culture à cet effet
C12N 5/02 - Propagation de cellules individuelles ou de cellules en suspensionLeur conservationMilieux de culture à cet effet
C12N 15/85 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules animales
C12N 9/12 - Transférases (2.) transférant des groupes contenant du phosphore, p. ex. kinases (2.7)
A61K 35/12 - Substances provenant de mammifèresCompositions comprenant des tissus ou des cellules non spécifiésCompositions comprenant des cellules souches non embryonnairesCellules génétiquement modifiées
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
The invention relates to a tool for an ultrasonic welding device, wherein a contact face of a carrier body (1) produced from a metal facing a component to be welded is provided with a diamond coating (3). To improve the durability, it is proposed in accordance with the invention for the diamond coating to be produced by means of CVD methods and to have a thickness (D2) in the range from 0.5 to 20 μm.
In a device and a corresponding method for joining a plurality of individual digital images to form a total image, a plurality of features is determined in a first individual image by means of a selection unit using a feature-based algorithm and then tracked in a second individual image by means of a tracking unit. A transformation matrix, with which the individual images are joined in an output unit to form the total image, is calculated from the determined feature correspondences in a transformation unit. The individual images can be joined in real time and with a high degree of accuracy by means of the feature-based algorithm in combination with a robust algorithm to calculate the transformation matrix.
The present invention concerns a method and a device for determining mechanical stress load, and optionally interface effects, on particles dispersed in a fluid. According to the invention, fluid comprising dispersed particles such as biomolecules is fed into a sample space of a device comprising a jacket which encloses a sample chamber and at least two rolls arranged within said jacket such that said sample space is defined between said rolls, said rolls being independently rotatable with respect to each other, wherein said jacket has an inner surface which is essentially adapted to the outer surface of the rolls, rotational movement is imparted to at least one of the rolls of said device, and changes in the state of said particles are determined from which mechanical stress load acting on the particles can be determined.
brevets
