A tissue holder cap for covering a tissue holder includes a cover having a perimeter, the cover having an outer surface and an inner surface opposite from the outer surface. The cover includes a central portion having an opening configured for receiving a central post of the tissue holder, a first latch extending from the perimeter of the cover, and a second latch extending from the perimeter of the cover, circumferentially spaced apart from the first latch. The cover also includes a first protrusion configured to engage the post of the tissue holder. When the first protrusion engages with the post, each of the first latch and the second latch automatically aligns with one or more of a plurality of tabs on located on a circumferential sidewall of the tissue holder to thereby securely fasten the tissue holder cap onto the tissue holder.
Disclosed are nucleic acid oligomers, including amplification oligomers, detection probes, and combinations thereof, for detection of one or more gastrointestinal pathogens expressing shiga toxin (stx). Also disclosed are methods of specific nucleic acid amplification and detection, including multiplex assays, using the disclosed oligomers, as well as corresponding reaction mixtures and kits.
C12Q 1/689 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les bactéries
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
Produits et services
Diagnostic reagents for scientific purposes; diagnostic
preparations for research laboratory use; buffer solutions
for scientific purposes. Diagnostic kits comprised of assays for testing of bodily
fluids for use in disease detection; diagnostic kits
comprising primarily diagnostic agents, preparations and
substances for medical purposes; diagnostic kits comprised
of medical diagnostic reagents; medical diagnostic reagents
and assays for testing of body fluids; diagnostic agents,
preparations and substances for medical purposes. Scientific apparatus for diagnostic testing of biological
samples, other than for medical purposes; research
laboratory analyzers for measuring, testing and analyzing
blood and other bodily fluids; diagnostic apparatus for the
detection of pathogens, not for medical purposes;
downloadable medical software for processing biological
samples; diagnostic apparatus for research laboratory use
for processing samples. Scientific apparatus for diagnostic testing of biological
samples, for medical purposes; diagnostic instruments for
medical purposes used for analyzing body fluids; medical
diagnostic apparatus for testing pathogens; medical
diagnostic apparatus for testing of biological samples
incorporating recorded software for processing the
biological samples; medical diagnostic apparatus for testing
biological samples incorporating recorded operating system
software.
4.
COMPOSITIONS AND METHODS FOR DETECTING GASTROINTESTINAL PATHOGENS
Disclosed are nucleic acid oligomers, including amplification oligomers and detection probes, for detection of Yersinia enterocolitica, Vibrio spp., Shiga Toxin Expressing E. coli (STEC) O157, and Plesiomonas shigelloides target nucleic acid. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligomers, as well as corresponding formulations, reaction mixtures, and kits. Methods of synthesizing the nucleic acid oligomers are also disclosed.
C12Q 1/04 - Détermination de la présence ou du type de micro-organismeEmploi de milieux sélectifs pour tester des antibiotiques ou des bactéricidesCompositions à cet effet contenant un indicateur chimique
C12Q 1/689 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les bactéries
Clostridium difficileClostridium difficile target nucleic acid. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligomers, as well as corresponding formulations, reaction mixtures, and kits. Methods of synthesizing the nucleic acid oligomers are also disclosed.
C12Q 1/6837 - Couplage enzymatique ou biochimique d’acides nucléiques à une phase solide utilisant des réseaux de sondes ou des puces à sondes
C12Q 1/686 - Réaction en chaine par polymérase [PCR]
C12Q 1/689 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les bactéries
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
Produits et services
Diagnostic reagents for scientific purposes; buffer
solutions for scientific purposes; diagnostic preparations
for research laboratory use. Diagnostic kits comprised of assays for testing of bodily
fluids for use in disease detection; diagnostic kits
comprising primarily diagnostic agents, preparations and
substances for medical purposes; diagnostic kits comprised
of medical diagnostic reagents; medical diagnostic reagents
and assays for testing of body fluids; diagnostic agents,
preparations and substances for medical purposes. Scientific apparatus for diagnostic testing of biological
samples, other than for medical purposes; research
laboratory analyzers for measuring, testing and analyzing
blood and other bodily fluids; diagnostic apparatus for
research laboratory use for processing samples; diagnostic
apparatus for the detection of pathogens, not for medical
purposes; downloadable medical software for processing
biological samples. Scientific apparatus for diagnostic testing of biological
samples, for medical purposes; diagnostic instruments for
medical purposes used for analyzing body fluids; medical
diagnostic apparatus for testing pathogens; medical
diagnostic apparatus for testing of biological samples
incorporating recorded software for processing the
biological samples; medical diagnostic apparatus for testing
biological samples incorporating recorded operating system
software.
7.
SYSTEMS AND METHODS FOR CORRELATING REGIONS OF INTEREST IN MULTIPLE IMAGING MODALITIES
Methods and systems for identifying a region of interest in breast tissue utilize artificial intelligence to confirm that a target lesion identified during imaging the breast tissue using a first imaging modality (e.g. x-ray imaging) has been identified using a second imaging modality (e.g. ultrasound imaging). A computing system operating a lesion matching engine utilizes a machine learning classifier algorithm trained on cases of x-ray images and corresponding ultrasound images in which lesions were identified for further analysis. The lesion matching engine analyzes a target lesion identified with x-ray imaging and a potential lesion identified with ultrasound imaging to determine a likelihood that the target lesion is the same as the potential lesion. A confidence level indicator for the lesion match is presented on a display of a computing device to aid a healthcare provider in locating a lesion in breast tissue.
G06V 10/75 - Organisation de procédés de l’appariement, p. ex. comparaisons simultanées ou séquentielles des caractéristiques d’images ou de vidéosApproches-approximative-fine, p. ex. approches multi-échellesAppariement de motifs d’image ou de vidéoMesures de proximité dans les espaces de caractéristiques utilisant l’analyse de contexteSélection des dictionnaires
A method for processing breast tissue image data includes processing the image data to generate a set of image slices collectively depicting the patient's breast; for each image slice, applying one or more filters associated with a plurality of multi-level feature modules, each configured to represent and recognize an assigned characteristic or feature of a high-dimensional object; generating at each multi-level feature module a feature map depicting regions of the image slice having the assigned feature; combining the feature maps generated from the plurality of multi-level feature modules into a combined image object map indicating a probability that the high-dimensional object is present at a particular location of the image slice; and creating a 2D synthesized image identifying one or more high-dimensional objects based at least in part on object maps generated for a plurality of image slices.
A61B 6/50 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations spécialement adaptés à des parties du corps spécifiquesAppareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations spécialement adaptés à des applications cliniques spécifiques
A61B 6/02 - Agencements pour établir un diagnostic dans des plans différents successifsDiagnostic stéréoscopique utilisant des radiations
G06T 17/10 - Description de volumes, p. ex. de cylindres, de cubes ou utilisant la GSC [géométrie solide constructive]
G06V 10/80 - Fusion, c.-à-d. combinaison des données de diverses sources au niveau du capteur, du prétraitement, de l’extraction des caractéristiques ou de la classification
G06V 30/24 - Reconnaissance de caractères caractérisée par la méthode de traitement ou de reconnaissance
9.
BREAST COMPRESSION AND IMAGING SYSTEMS AND METHODS
A compression paddle with a plurality of markers is advanced towards a patient's breast which has been positioned on a support platform for an imaging procedure. An initial position of the compression paddle is detected relative to the support platform when a portion of the breast is contacted. An initial marker is identified which is associated with a feature of the breast when the compression paddle is in the initial position. A compression target marker is based at least in part on the initial position and the initial marker.
A61B 6/04 - Mise en position des patientsLits inclinables ou similaires
A61B 6/46 - Agencements pour l’interface avec l’opérateur ou avec le patient
A61B 6/50 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations spécialement adaptés à des parties du corps spécifiquesAppareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations spécialement adaptés à des applications cliniques spécifiques
10.
SYSTEMS AND METHODS FOR AUTOMATED PREPARATION OF BIOLOGICAL SPECIMENS
An automated system for processing a sample contained in a liquid sample container includes an automated tool head configured to rotate about a first axis, and to translate along a second axis different than the first axis, a pipettor carried by the tool head, the pipettor having a pipette tip engaging member configured to releasably engage pipette tips, and a supplemental container holder configured for holding a supplemental container, the tool head configured to automatically position the pipette tip engaging member into a position in which an engaged pipette tip is inserted into a sample container held in the sample container holder, and into a position in which an engaged pipette tip is inserted into a supplemental container held in the supplemental container holder, through one or both of rotation of the tool head about the first axis and translation of the tool head along the second axis.
G01N 1/28 - Préparation d'échantillons pour l'analyse
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
An actuating mechanism is configured to operate circularly arranged flow control valves of a fluidic device. A valve actuator piston is operably engageable with each of the valves for selectively opening or closing the associated valve and is spring biased into a first (open or closed) position. Each piston includes a cam follower surface. A rotary cam is rotatable about the center of the circular arrangement of valves and comprises an axially-extending cam rod that is rotatable about the center and a cam disposed on an outer end of the cam rod. Rotation of the cam rod about the center to a rotational position of a selected one of the valve actuator pistons causes the cam to engage the cam follower surface of the selected piston and move the selected piston against the spring bias from the first position to the second position.
F16K 31/524 - Moyens mécaniques d'actionnement à manivelle, excentrique ou came à came
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
12.
SYSTEMS AND METHODS FOR LATERAL TREATMENTS OF THE BREAST
An adapter for securing a biopsy guidance module to a breast imaging system includes an adapter body which includes a first side and an opposite second side. An armature extends from the first side of the body. A latch mechanism is disposed proximate an end of the armature distal from the first side of the body. The latch mechanism includes an adapter latch and an actuator. The adapter latch is configured to engage an interface on the breast imaging system. The actuator is engaged with the adapter latch to move the adapter latch from an unlocked position to a locked position. In the locked position, the adapter latch is releasably engaged with the interface. A keeper is disposed on the second side of the body. The keeper is configured to receive a module latch from the biopsy guidance module.
A61B 6/50 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations spécialement adaptés à des parties du corps spécifiquesAppareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations spécialement adaptés à des applications cliniques spécifiques
A61B 6/00 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations
A61B 6/04 - Mise en position des patientsLits inclinables ou similaires
A61B 10/02 - Instruments pour prélever des échantillons cellulaires ou pour la biopsie
A61B 90/11 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures pour la chirurgie stéréotaxique, p. ex. système stéréotaxique à cadre avec des guides pour aiguilles ou instruments, p. ex. des glissières courbes ou des articulations à rotule
A61B 90/17 - Fixateurs pour parties du corps, p. ex. clamps crâniensDétails de construction des fixateurs, p. ex. broches pour tissus mous, p. ex. supports mammaires
An imaging system that is configured to automatically obtain and provide two and three-dimensional digital images of various types of objects (e.g., tissue specimens, animals, electrical devices, etc.) for use in analysis thereof in a manner free of manual repositioning of the objects between images and free of movement of an electromagnetic radiation source and detector within or relative to a cabinet housing of the system.
A61B 6/00 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations
An actuator for actuating valves of a fluidic device includes an actuator piston for each valve that is movable between first and second positions corresponding to open and closed positions of the engaged valve. At least one camshaft is supported for rotation and includes at least one cam lobe. An actuator lever is associated with each cam lobe and with each piston and includes a pivot connection enabling the lever to pivot, a piston engagement at which the lever is engaged with the associated piston so that pivoting of the lever in a first direction moves the piston from its first position to its second position, and a cam follower disposed between the pivot connection and the piston engagement, the cam follower being engaged by an associated cam lobe as the camshaft rotates to cause the lever to pivot.
F16K 31/04 - Moyens de fonctionnementDispositifs de retour à la position de repos électriquesMoyens de fonctionnementDispositifs de retour à la position de repos magnétiques utilisant un moteur
F16K 31/524 - Moyens mécaniques d'actionnement à manivelle, excentrique ou came à came
G01N 1/20 - Dispositifs pour prélever des échantillons à l'état liquide ou fluide pour matériau coulant ou s'éboulant
Provided is a method for amplifying a nucleic acid which is suspected to be present in a sample in a low copy number comprises the following steps: i. providing a first reaction mixture in a reaction chamber wherein the first reaction mixture comprises a first portion of the sample; ii. subjecting the first reaction mixture in the reaction chamber to conditions allowing a pre-amplification of the nucleic acid in order to obtain a first pre-amplification mixture; iii. providing a second reaction mixture in the reaction chamber wherein the second reaction mixture comprises a subset of the first pre-amplification mixture and a second portion of the sample; iv. subjecting the second reaction mixture to conditions allowing a pre-amplification of the nucleic acid in order to obtain a second pre-amplification mixture; v. optionally, repeating steps iii) and iv) a number N additional times in order to obtain an (N+2) pre-amplification mixture; vi. subjecting the second pre-amplification mixture obtained in step (iv) or the (N+2) pre-amplification mixture obtained in step (v) to conditions allowing an amplification of the nucleic acid in order to obtain an amplification mixture, wherein the sample has a total sample volume which exceeds a volume capacity of the reaction chamber.
C12Q 1/6848 - Réactions d’amplification d’acides nucléiques caracterisées par les moyens d’empêcher la contamination ou d’augmenter la spécificité ou la sensibilité d’une réaction d’amplification
C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique
16.
Manufacturing a Fluid Cartridge having a Lysis Chamber
A method of manufacturing a fluidic cartridge includes providing a cartridge body with a sample chamber having an open first end and a sample exit port at a second end and one or more chambers that are that are fluidly connected or connectable with the sample chamber. First and second porous membranes are provided and the second membrane is affixed within the sample chamber covering the sample exit port. Non-magnetic beads and at least one magnetic element are introduced into the sample chamber. The first membrane is then affixed within the sample chamber, overlapping the open first end of the sample chamber. An internal wall of the sample chamber and the affixed first and second membranes define a lysis chamber. Pores of the first and second membranes are sized to retain the non-magnetic beads and the magnetic element within the lysis chamber.
C12M 3/06 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus avec des moyens de filtration, d'ultrafiltration, d'osmose inverse ou de dialyse
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
17.
SYSTEM AND METHODS FOR LAB AUTOMATION DATA SHARING
A method for sharing system information data in a network of two or more analyzers for performing assays is provided. The system information data includes operating information for the analyzers in the network. The method includes: sending a system information metadata packet to at least a first analyzer in the network, wherein the system information metadata packet is associated with system information data on a second analyzer in the network and comprises one or more attributes of a system information data packet containing the associated system information data; receiving a request from the first analyzer to send the system information data packet; and in response to the request from the first analyzer to send the system information data packet, sending the system information data packet containing the associated system information data to the first analyzer.
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
G16H 10/40 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données relatives aux analyses de laboratoire, p. ex. pour des analyses d’échantillon de patient
A method of processing a sample includes verifying that an identifier of a first carrier detected at a first position on a host conveyor assembly is associated with a first sample on which a first assay is scheduled to be performed with a first instrument. The method includes diverting the first carrier from the host conveyor assembly to a first intermediate conveyor assembly. The method includes transporting the first carrier to a first processing position within the first instrument. The method includes verifying that an identifier of the first carrier detected at the first processing position is associated with the first sample. The method includes transferring at least a portion of the first sample from a first processing receptacle coupled to the first carrier to a first assay receptacle. The method includes performing the first assay by subjecting the portion of the first sample to nucleic acid amplification reaction conditions.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p. ex. pour test de réaction en chaîne par polymérase [PCR]
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
A method for lysing cells in a fluid sample includes providing the sample to a sample chamber of a fluidic cartridge and securing a cap to an open end of the sample chamber. The cap includes a deformable wall defining a chamber containing lytic agents and enclosed by a frangible membrane. The lytic agents include non-magnetic beads and at least one magnetic element, and the size of the magnetic element is greater than the size of any of the non-magnetic beads. A force is applied to a top end of the deformable wall, thereby collapsing the chamber such that the lytic agents rupture the frangible membrane and are released into the sample chamber. The fluid sample and the lytic agents are subjected to a magnetic field causing the magnetic element to agitate the non-magnetic beads to lyse cells within the fluid sample.
A fluidic cartridge includes a sample chamber having an open top end and a sample exit port and a lysis chamber within the sample chamber. The lysis chamber is defined by an inner wall of the sample chamber, a first porous membrane affixed within the sample chamber, the first porous membrane overlapping the open top end, and a second porous membrane spaced apart from the first porous membrane affixed within the sample chamber, the second porous membrane overlapping the sample exit port. At least one magnetic element and a plurality of non-magnetic beads are contained within the lysis chamber, and the pores of the first and the second porous membranes are sized to retain the magnetic element and the non-magnetic beads within the lysis chamber.
Capture mixtures and activated capture mixtures are provided that are useful for nucleic acid separation and purification are provided. The mixtures comprise lithium lauryl sulfate, lithium hydroxide, a zwitterionic sulfonic acid buffering agent, and optionally, proteinase K, capture probes comprising a first specific binding partner (SBP), and a second specific binding partner immobilized to a solid support. Related combinations, methods, uses, and kits, are also provided.
A method for lysing cells in a fluid sample includes positioning an electromagnet within a predetermined distance from a sample chamber of a microfluidic device which contains the fluid sample and lytic agents including non-magnetic beads and at least one magnetic element. A magnetic field generated by the electromagnet is targeted at the sample and the lytic agents contained in the sample chamber. The electromagnet is spatially separated from the sample chamber and held stationary while generating the magnetic field, and the polarity of the magnetic field is reversed, thereby causing the magnetic element to move in a random manner within the sample chamber to agitate the non-magnetic beads to lyse cells contained within the fluid sample and release nucleic acids from the lysed cells.
Examples of the present disclosure describe systems and methods for using AI to identify regions of interest (ROI) in medical images. In aspects, medical reports and images may be provided to a second environment. The second environment may use the medical report data/medical images to train a natural language processing (NLP)-based algorithm to identify the location in images of ROI described in the medical report data. The output of the NLP-based algorithm may be stored in an ROI repository in the second environment. After the NLP-based algorithm has been trained, a request to train a user-specific model may be received in a first environment. Data objects for the requested user-specific model may be provided to the second environment, which uses the ROI repository to train the model. The trained model may be provided to the first environment, where the trained user-specific model/algorithm may be tested and stored.
G06V 10/22 - Prétraitement de l’image par la sélection d’une région spécifique contenant ou référençant une formeLocalisation ou traitement de régions spécifiques visant à guider la détection ou la reconnaissance
G06F 18/21 - Conception ou mise en place de systèmes ou de techniquesExtraction de caractéristiques dans l'espace des caractéristiquesSéparation aveugle de sources
G06F 18/214 - Génération de motifs d'entraînementProcédés de Bootstrapping, p. ex. ”bagging” ou ”boosting”
G06F 21/62 - Protection de l’accès à des données via une plate-forme, p. ex. par clés ou règles de contrôle de l’accès
G06F 40/40 - Traitement ou traduction du langage naturel
A method for processing a fluid sample in a fluidic cartridge with a chamber expander secured with respect to one of two or more wells of uniform height to expand a volumetric capacity of the one well by the volumetric capacity of the chamber expander, the two or more wells being fluidly connected or connectable. The method includes dispensing fluid sample into an opening defined by a mouth of the chamber expander, the amount of fluid sample completely filling the well and at least partially filling the chamber expander, and coupling a cap to the mouth of the chamber expander to close the opening.
A hybrid image based on different tissue specimen images is generated to compensate for blood and other fluids that interfere with imaging. Specimen is deposited into tray with fluid. X-ray and camera imaging devices acquire images of specimen and fluid. X-ray and optical images are processed for generation of hybrid image. Transparency modifications allow for multiple and different images to contribute to depiction of specimen edges or boundaries that would otherwise appear less clear in x-ray image due to interfering fluid. Transparency modifications in hybrid image also provide for sufficiently high transparency in certain optical image portions that would otherwise be opaque so that objects of interest depicted in x-ray image but not optical image are visible.
A61B 10/02 - Instruments pour prélever des échantillons cellulaires ou pour la biopsie
A61B 10/00 - Instruments pour le prélèvement d'échantillons corporels à des fins de diagnostic Autres procédés ou instruments pour le diagnostic, p. ex. pour le diagnostic de vaccination ou la détermination du sexe ou de la période d'ovulationInstruments pour gratter la gorge
A cartridge for detecting an analyte by exposing a reaction mixture to an excitation optical signal and detecting an emission optical signal from the reaction mixture includes a cartridge body, a film affixed to a first portion of a surface of the cartridge body; and a thermally-conductive laminate seal affixed to a second portion of the surface. The cartridge body includes one or more reaction chambers, each having a wall that permits an optical signal to pass through the wall. The laminate seal covers an open end of the reaction chamber and includes a plastic layer affixed to the second portion of the surface of the cartridge body and a conductive layer affixed to the plastic layer opposite a surface of the plastic affixed to the second portion of the surface.
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
G01N 21/77 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé en observant l'effet sur un réactif chimique
A method of automated sample processing includes aspirating a portion of a first sample from a first sample containing receptacle. The method includes dispensing the first sample portion into a first processing receptacle. The method includes transporting a first carrier coupled to the first processing receptacle containing the first sample from a position inside the first instrument to a host conveyor assembly using a first intermediate conveyor assembly. The method includes transporting the first carrier from the host conveyor assembly to a first processing position within a second instrument using a second intermediate conveyor assembly. The method includes aspirating a portion of the first sample from the first processing containing receptacle. The method includes dispensing the portion of the first sample into a first assay receptacle. The method includes performing a first assay on the portion of the first sample in the first assay receptacle using the second instrument.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p. ex. pour test de réaction en chaîne par polymérase [PCR]
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
A cap for dispensing lytic agents into a sample well of a fluidic cartridge includes a deformable wall defining a chamber. A lower sleeve situated beneath the deformable wall defines a recess that is open to the chamber. A frangible membrane affixed to an end of the lower sleeve encloses the recess and the chamber. Lytic agents comprising non-magnetic beads and a magnetic element are contained within the chamber and the recess. A method for lysing cells contained in a sample includes providing sample to the sample well, inserting the cap into the well, applying a force to the deformable wall so the lytic agents rupture the frangible membrane and are released into the well, and subjecting the sample and the lytic agents to a magnetic field causing the magnetic element to agitate the non-magnetic beads to lyse cells contained within the sample.
A method of transporting a carrier coupled to a receptacle to a processing position within an instrument. The method includes a step of transporting the carrier coupled to the receptacle from a first carrier position outside the instrument to a second carrier position located on a spur conveyor, where the first carrier position is laterally offset from the second carrier position. The method includes a step of grasping the carrier coupled to the receptacle at the second carrier position with a gripper of the spur conveyor. The method includes a step of moving the gripper, while the gripper is grasping the carrier coupled to the receptacle, along a first linear path defined by the spur conveyor to transport the carrier coupled to the receptacle from the second carrier position to the processing position within the instrument.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p. ex. pour test de réaction en chaîne par polymérase [PCR]
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
Provided are compositions, kits, and methods that can be used to selectively amplify a first target nucleic acid that is distinguishable from a second target nucleic acid, where the two target nucleic acids have both common and different sequence domains. Structured primers useful in the amplification method include 5′ and 3′ target-hybridizing sequences separated from each other by a joining region that does not hybridize to the target nucleic acid. Polymerase-based extension of the structured primer depends on specific hybridization of the 5′ sequence of the primer, thereby facilitating hybridization and extension of the 3′ sequence of the primer.
An instrument for applying thermal energy to a reaction chamber of a test platform includes first and second heaters disposed in a spaced-apart configuration to receive the reaction chamber in a position so that the first and second heaters contact different parts of the reaction chamber. Each heater is configured to apply thermal energy to the reaction chamber by conductive heat transfer through a part of the reaction chamber contacted by the respective heater. A first controller is configured to control thermal energy generated by the first heater, and a second controller is configured to control thermal energy generated by the second heater. The first and second controllers control thermal energy generated by the first and second heaters, respectively, independently of each other to achieve a common temperature profile for the first heater and the second heater.
G01N 1/44 - Traitement d'échantillons mettant en œuvre un rayonnement, p. ex. de la chaleur
H05B 1/02 - Dispositions de commutation automatique spécialement adaptées aux appareils de chauffage
H10N 10/10 - Dispositifs thermoélectriques comportant une jonction de matériaux différents, c.-à-d. dispositifs présentant l'effet Seebeck ou l'effet Peltier fonctionnant exclusivement par les effets Peltier ou Seebeck
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
Produits et services
Scientific apparatus for diagnostic testing of biological samples, other than for medical purposes; research laboratory analyzers for measuring, testing and analyzing blood and other bodily fluids; diagnostic apparatus for the detection of pathogens, not for medical purposes; downloadable medical software for processing biological samples; diagnostic apparatus for research laboratory use for processing samples; Diagnostic apparatus for research laboratory use for processing fluids or fluidized samples Scientific apparatus for diagnostic testing of biological samples, for medical purposes; diagnostic instruments for medical purposes used for analyzing body fluids; medical diagnostic apparatus for testing pathogens; medical diagnostic apparatus for testing of biological samples incorporating recorded software for processing the biological samples; medical diagnostic apparatus for testing biological samples incorporating recorded operating system software; Medical diagnostic apparatus for testing fluids or fluidized samples incorporating recorded software for operating diagnostic apparatus
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
Produits et services
Scientific apparatus for diagnostic testing of biological samples, other than for medical purposes; research laboratory analyzers for measuring, testing and analyzing blood and other bodily fluids; diagnostic apparatus for the detection of pathogens, not for medical purposes; downloadable medical software for processing biological samples; diagnostic apparatus for research laboratory use for processing samples; Diagnostic apparatus for research laboratory use for processing fluids or fluidized samples Scientific apparatus for diagnostic testing of biological samples, for medical purposes; diagnostic instruments for medical purposes used for analyzing body fluids; medical diagnostic apparatus for testing pathogens; medical diagnostic apparatus for testing of biological samples incorporating recorded software for processing the biological samples; medical diagnostic apparatus for testing biological samples incorporating recorded operating system software; Medical diagnostic apparatus for testing fluids or fluidized samples incorporating recorded software for operating diagnostic apparatus
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
Produits et services
(1) Diagnostic reagents for scientific purposes; diagnostic preparations for research laboratory use; buffer solutions for scientific purposes.
(2) Diagnostic kits comprised of assays for testing of bodily fluids for use in disease detection; diagnostic kits comprising primarily diagnostic agents, preparations and substances for medical purposes; diagnostic kits comprised of medical diagnostic reagents; medical diagnostic reagents and assays for testing of body fluids; diagnostic agents, preparations and substances for medical purposes.
(3) Scientific apparatus for diagnostic testing of biological samples, other than for medical purposes; research laboratory analyzers for measuring, testing and analyzing blood and other bodily fluids; diagnostic apparatus for the detection of pathogens, not for medical purposes; downloadable medical software for processing biological samples; diagnostic apparatus for research laboratory use for processing samples.
(4) Scientific apparatus for diagnostic testing of biological samples, for medical purposes; diagnostic instruments for medical purposes used for analyzing body fluids; medical diagnostic apparatus for testing pathogens; medical diagnostic apparatus for testing of biological samples incorporating recorded software for processing the biological samples; medical diagnostic apparatus for testing biological samples incorporating recorded operating system software.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
Produits et services
(1) Diagnostic reagents for scientific purposes; buffer solutions for scientific purposes; diagnostic preparations for research laboratory use.
(2) Diagnostic kits comprised of assays for testing of bodily fluids for use in disease detection; diagnostic kits comprising primarily diagnostic agents, preparations and substances for medical purposes; diagnostic kits comprised of medical diagnostic reagents; medical diagnostic reagents and assays for testing of body fluids; diagnostic agents, preparations and substances for medical purposes.
(3) Scientific apparatus for diagnostic testing of biological samples, other than for medical purposes; research laboratory analyzers for measuring, testing and analyzing blood and other bodily fluids; diagnostic apparatus for research laboratory use for processing samples; diagnostic apparatus for the detection of pathogens, not for medical purposes; downloadable medical software for processing biological samples.
(4) Scientific apparatus for diagnostic testing of biological samples, for medical purposes; diagnostic instruments for medical purposes used for analyzing body fluids; medical diagnostic apparatus for testing pathogens; medical diagnostic apparatus for testing of biological samples incorporating recorded software for processing the biological samples; medical diagnostic apparatus for testing biological samples incorporating recorded operating system software.
36.
Instrument with a detector that contacts a cartridge within the instrument
An instrument includes a first chassis and a second chassis that includes a cartridge support cradle configured to hold a cartridge with a sample chamber between the first and second chassis. An actuator coupled to one or both of the first and second chassis is configured to effect automated relative movement between the first and second chassis to vary a distance therebetween. A detector mounted within the upper chassis includes a plunger rod movable between first and second positions and a sensor for detecting when the plunger rod is in the second position. As the first and second chassis are moved relatively toward each other by the actuator, if the fluidic cartridge is situated on the cartridge support cradle, and a cap closes the sample chamber, the plunger rod will contact the cap and move from the first position to the second position.
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
Disclosed are compositions and methods for performing nucleic-acid-based assays to determine the presence or absence of a target nucleic acid in a biological sample. The disclosed methods include the use of one or more oligomers that specifically hybridize to a nucleolin nucleic acid to assess the cellularity of the biological sample. Also disclosed are related composition and methods for assessing the cellularity of a biological sample for use in a molecular diagnostic assay.
C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
C12Q 1/6816 - Tests d’hybridation caractérisés par les moyens de détection
C12Q 1/6848 - Réactions d’amplification d’acides nucléiques caracterisées par les moyens d’empêcher la contamination ou d’augmenter la spécificité ou la sensibilité d’une réaction d’amplification
38.
THERMAL MODULE WITH OPTICAL FIBERS EXTENDING THERETHROUGH
An assembly includes first and second thermal modules. Each thermal module includes at least one thermal assembly comprising a thermal element in thermal contact with an associated thermal block. Each thermal block has an exposed contact surface, and each contact surface of the second thermal module is situated in aligned opposition with respect to an associated contact surface of the first thermal module. A thermal module actuator is configured to effect automated relative movement between the first thermal module and the second thermal module to vary a distance between the contact surface of each thermal assembly of the second thermal module and the associated contact surface of each thermal assembly of the first thermal module. An optical fiber is associated with a through hole extending through the thermal block of each thermal assembly of the first thermal module to transmit an optical signal through each thermal block of the first thermal module.
A system for visualizing and guiding a surgical device having a first imaging device of a first type and has a first image output. The first imaging device is positioned to image an area being subject to surgery. A second imaging device of a second type has a second image output. The second imaging device is positioned to image an area being subject to surgery. A computer is coupled to receive the first and second image outputs and a computer software program, resident in the computer receives and displays information received from the surgical device and/or for guiding the operation of the surgical device and for generating a graphic user interface including selectable menu and submenu items. The surgical device is coupled to the computer.
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 8/00 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores
A61B 8/12 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores dans des cavités ou des conduits du corps, p. ex. en utilisant des cathéters
A61B 34/00 - Chirurgie assistée par ordinateurManipulateurs ou robots spécialement adaptés à l’utilisation en chirurgie
A61B 34/20 - Systèmes de navigation chirurgicaleDispositifs pour le suivi ou le guidage d'instruments chirurgicaux, p. ex. pour la stéréotaxie sans cadre
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures
40.
Enzyme Formulations and Reaction Mixtures for Nucleic Acid Amplification
Disclosed is a kit for performing an amplification reaction to identify a target sequence in a sample containing a detergent. The kits and compositions include a first sealed container comprising a lyophilized formulation and a second sealed container which includes an aqueous solution. The lyophilized formulation includes amplification oligomers configured to amplify the target sequence, a polymerase, dNTPs, a cyclodextrin, a chelating agent, a lyoprotectant and a surfactant. The aqueous solution includes a buffering agent and an inorganic salt.
C12N 9/12 - Transférases (2.) transférant des groupes contenant du phosphore, p. ex. kinases (2.7)
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p. ex. pour test de réaction en chaîne par polymérase [PCR]
C12Q 1/686 - Réaction en chaine par polymérase [PCR]
41.
SYSTEMS AND METHODS FOR MEASURING THICKNESS OF FOAM COMPRESSIVE ELEMENTS
A method of imaging a breast of a patient with a breast imaging system includes supporting the breast on a breast support platform. A compressive force is applied to the breast with a breast immobilization element including a rigid substrate, a foam compressive element secured below the rigid substrate, and a force sensor. The foam compressive element is in contact with the breast during application of the compressive force. A force signal is detected at the force sensor based on the applied compressive force. A compressed thickness of the breast proximate the force sensor is determined based at least in part on the detected force signal at the force sensor. An automatic exposure control is set based at least in part on the determined thickness of the breast proximate the force sensor.
A61B 6/50 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations spécialement adaptés à des parties du corps spécifiquesAppareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations spécialement adaptés à des applications cliniques spécifiques
A61B 6/00 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations
A61B 6/04 - Mise en position des patientsLits inclinables ou similaires
42.
COMPOSITIONS AND METHODS FOR AMPLIFYING, DETECTING OR QUANTIFYING HUMAN CYTOMEGALOVIRUS
Oligomer nucleotides, compositions, methods, kits, and uses are provided for detecting or quantifying a Human Cytomegalovirus virus 1 (CMV (human herpesvirus 5, HHV5) nucleic acid, e.g., using nucleic acid amplification and hybridization assays. Multiphase amplification of a CMV target sequence is also described. The oligomer nucleotides, compositions, methods, kits, and uses can be used to amplify and/or detect the UL56 gene of CMV.
C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
A fluidic cartridge includes a cartridge body defining two or more fluidly connected wells, and at least one of the wells comprises an expansion well. A first coupling structure at least partially surrounds the expansion well, and a chamber expander is attached to the cartridge body. The chamber expander includes a base with a second coupling structure located on a bottom side of the base and configured to be operatively coupled to the first coupling structure to form a hermetic seal between the chamber expander and the cartridge body. An expansion chamber extends from the base to expand the capacity of the expansion well by at least the capacity of the expansion chamber. A mouth defines an opening into an interior space of the expansion chamber, and a cap is configured to be coupled to the mouth to close the opening.
Mycoplasma genitaliumgenitaliumgenitaliumgenitalium. Advantageously, the disclosed technique reduces the incidence of false-positive identification of macrolide resistance.
C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique
C12Q 1/689 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les bactéries
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
Produits et services
Automated laboratory equipment for handling and processing biological samples for laboratory use; Computer software for the operation of automated laboratory equipment for handling and processing biological samples; computer software for the organization and transport of biological samples Automated laboratory equipment for handling and processing biological samples for medical use
Disclosed are methods for diagnosing Bacterial Vaginosis in a subject comprising performing an assay for the detection of any one or more of Lactobacillus sp., Atopobium vaginae, and Gardnerella vaginalis in a subject sample. Also disclosed are compositions and methods for detecting Lactobacillus sp., Atopobium vaginae, and/or Gardnerella vaginalis nucleic acid in a sample.
C12Q 1/689 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les bactéries
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
Produits et services
Electronic publications, namely instrument manuals and guides for operating diagnostic instruments recorded on computer media; downloadable software for operating diagnostic instruments; diagnostic instrument, and parts thereof, for scientific or research use, and downloadable operating software for diagnostic instrument use therewith Diagnostic instrument, and parts thereof, for clinical or medical use, namely, automated in vitro diagnostic specimen analyzer instrument for the detection of analytes
49.
SPECIMEN RADIOGRAPHY SYSTEM COMPRISING CABINET AND A SPECIMEN DRAWER POSITIONABLE BY A CONTROLLER IN THE CABINET
A specimen radiography system may include a controller and a cabinet. The cabinet may include an x-ray source, an x-ray detector, and a specimen drawer disposed between the x-ray source and the x-ray detector. The specimen drawer may be automatically positionable along a vertical axis between the x-ray source and the x-ray detector.
A61B 6/02 - Agencements pour établir un diagnostic dans des plans différents successifsDiagnostic stéréoscopique utilisant des radiations
A61B 6/00 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations
A61B 6/40 - Agencements pour générer des radiations spécialement adaptés au diagnostic par radiations
A61B 6/42 - Agencements pour détecter des radiations spécialement adaptés au diagnostic par radiations
A61B 6/46 - Agencements pour l’interface avec l’opérateur ou avec le patient
A61B 6/50 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations spécialement adaptés à des parties du corps spécifiquesAppareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations spécialement adaptés à des applications cliniques spécifiques
G01N 23/04 - Recherche ou analyse des matériaux par l'utilisation de rayonnement [ondes ou particules], p. ex. rayons X ou neutrons, non couvertes par les groupes , ou en transmettant la radiation à travers le matériau et formant des images des matériaux
G01N 23/044 - Recherche ou analyse des matériaux par l'utilisation de rayonnement [ondes ou particules], p. ex. rayons X ou neutrons, non couvertes par les groupes , ou en transmettant la radiation à travers le matériau et formant des images des matériaux en utilisant la laminographie ou la tomosynthèse
G01N 23/06 - Recherche ou analyse des matériaux par l'utilisation de rayonnement [ondes ou particules], p. ex. rayons X ou neutrons, non couvertes par les groupes , ou en transmettant la radiation à travers le matériau et mesurant l'absorption
G01N 23/083 - Recherche ou analyse des matériaux par l'utilisation de rayonnement [ondes ou particules], p. ex. rayons X ou neutrons, non couvertes par les groupes , ou en transmettant la radiation à travers le matériau et mesurant l'absorption le rayonnement consistant en rayons X
G01N 23/087 - Recherche ou analyse des matériaux par l'utilisation de rayonnement [ondes ou particules], p. ex. rayons X ou neutrons, non couvertes par les groupes , ou en transmettant la radiation à travers le matériau et mesurant l'absorption le rayonnement consistant en rayons X en utilisant des rayons X polyénergétiques
G01N 23/18 - Recherche de la présence de défauts ou de matériaux étrangers
G21K 7/00 - Microscopes à rayons gamma ou à rayons X
50.
LYSIS IN A FLUIDIC CARTRIDGE BY MAGNETIC AGITATION OF LYSIS ELEMENTS AND WITH INTERNAL CONTROL
A fluid sample is dispensed into a sample chamber of a fluidic cartridge, the sample chamber containing non-magnetic beads and a magnetic element. A portion of the non-magnetic beads and magnetic element have an internal control reagent containing an internal control deposited thereon for validating an assay result and/or to validate the effectiveness of a cell lysis procedure. The magnetic element is exposed to a magnetic field, thereby causing movement of the magnetic element, which causes movement of the non-magnetic beads. Movement of the non-magnetic beads causes cells contained within the fluid sample to lyse and release nucleic acids. The internal control reagent dissolves in the presence of the fluid sample, thereby releasing the internal control into the fluid sample, and the movement of the magnetic element and the non-magnetic beads causes the internal control to be distributed within the fluid sample.
A fluid sample is dispensed into a sample chamber of a fluidic cartridge, the sample chamber containing non-magnetic beads, a magnetic element, and an internal control reagent contained within an internal control pellet including an internal control for validating an assay result and/or to validate the effectiveness of a cell lysis procedure. The magnetic element is exposed to a magnetic field, thereby causing movement of the magnetic element, which causes movement of the non-magnetic beads. Movement of the non-magnetic beads causes cells contained within the fluid sample to lyse and release nucleic acids. The internal control reagent dissolves in the presence of the fluid sample or movement of the non-magnetic beads disintegrates the internal control pellet, thereby releasing the internal control into the fluid sample. Movement of the magnetic element and the non-magnetic beads causes the internal control to be distributed within the fluid sample.
A cryogenic probe includes a body having an active region configured to be inserted within a treatment region of a patient. The active region is defined by one or more internal passages configured to receive a flow of cryogenic fluid. The cryogenic probe body comprises one or more echogenic features on an exterior surface of the cryogenic probe body. The echogenic features are positioned to visually identify at least a portion of the active region under imaging. Disclosed devices, systems, and methods relate to cryoablation and imaging of treatment regions and cryogenic probes.
A61B 18/02 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par refroidissement, p. ex. techniques cryogéniques
A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
A61B 34/20 - Systèmes de navigation chirurgicaleDispositifs pour le suivi ou le guidage d'instruments chirurgicaux, p. ex. pour la stéréotaxie sans cadre
A curved compression element, such as a breast compression paddle, and imaging systems and methods for use with curved compression elements. A system may include a radiation source, a detector, and a curved compression element. Operations are performed that include receiving image data from the detector; accessing a correction map for the at least one compression paddle; correcting the image data based on the correction map to generate a corrected image data; and generating an image of the breast based on the corrected image data. The breast compression element generally has no sharp edges, but rather has smooth edges and transitions between surfaces. The breast compression paddle also includes a flexible material that spans a portion of a curved bottom surface of the breast compression paddle to define a gap. The flexible material may be a thin-film material such as a shrink wrap.
A61B 6/50 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations spécialement adaptés à des parties du corps spécifiquesAppareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations spécialement adaptés à des applications cliniques spécifiques
A61B 6/00 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations
A61B 6/04 - Mise en position des patientsLits inclinables ou similaires
A lysis vessel for performing cell lysis includes a laterally extending member and a sleeve having a bottom end defining an open bottom end of the vessel. A first porous membrane is affixed to a top or bottom surface of the laterally extending member and covers a vent in the member. A second porous membrane is affixed to the bottom end of the sleeve and covers the open bottom end. The bottom surface of the laterally extending member, an inner surface of the sleeve, and the first and second porous membranes define a lysis chamber. A plurality of non-magnetic beads are contained within the lysis chamber, and at least one magnetic element is contained within the lysis chamber. The first and the second porous membranes are sized to retain the plurality of non-magnetic beads and the at least one magnetic element within the lysis chamber.
Systems and methods of adaptively controlling filament current in an x-ray tube of an imaging system include the x-ray tube having a filament being calibrated. Calibration data from the calibration of the x-ray tube is stored at the imaging system, the calibration data including a filament current value that determines a tube current value for a tube voltage value at a plurality of stations. A resistance value of the filament over a period of time is monitored. A change in the resistance value of the filament over the period of time is determined, and the filament current value of at least one of the plurality of stations is adjusted based on the changed resistance value.
H05G 1/34 - Commande du courant anodique, du courant de chauffage ou de la tension de chauffage de tube à rayons X
A61B 6/50 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations spécialement adaptés à des parties du corps spécifiquesAppareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations spécialement adaptés à des applications cliniques spécifiques
The invention pertains to a carrier support for holding a carrier, wherein the carrier is configured to hold a plurality of receptacles, wherein the carrier support is configured to be moveable between a first position and a second position, and wherein the carrier support comprises a carrier locking mechanism configured to lock the carrier with respect to the carrier support when the carrier support is moved to the second position and to release the carrier when the carrier support is moved to the first position to permit the carrier to be moved with respect to the carrier support when the carrier support is in the first position. The carrier locking mechanism comprises a pivoting latch configured to pivot with respect to the carrier support between a first position not engaged with a portion of the carrier and a second position engaged with a portion of the carrier, and a slide latch configured to translate linearly with respect to the carrier support between a first position not engaged with a portion of the carrier and a second position engaged with a portion of the carrier.
B65G 47/74 - Dispositifs d'alimentation, de transfert ou de déchargement de genres ou types particuliers
G01N 35/02 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet en utilisant une série de récipients à échantillons déplacés par un transporteur passant devant un ou plusieurs postes de traitement ou d'analyse
59.
Systems and methods for capacitive fluid level detection, and handling containers
A fluid container holder includes a body having a receptacle configured to receive a container. The body has a conductive outer surface for connection to an electrical ground or voltage source, and the holder is not formed solely of an electrically conductive metal. A fluid container handling assembly includes a drawer having a holder supporting a fluid container, and a frame supporting the holder. The frame is movable between a first position providing access to the holder and a second position positioning the holder within the instrument. The assembly also includes a first lock securing the holder to the frame when the frame is at the first frame position and unlocking the holder from the frame when the frame is at the second frame position. The assembly also includes a holder transporter configured to move the holder between a first holder position and a second holder position within the instrument.
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p. ex. pour test de réaction en chaîne par polymérase [PCR]
C12Q 1/686 - Réaction en chaine par polymérase [PCR]
G01F 23/263 - Indication ou mesure du niveau des liquides ou des matériaux solides fluents, p. ex. indication en fonction du volume ou indication au moyen d'un signal d'alarme en mesurant des variables physiques autres que les dimensions linéaires, la pression ou le poids, selon le niveau à mesurer, p. ex. par la différence de transfert de chaleur de vapeur ou d'eau en mesurant les variations de capacité ou l'inductance de condensateurs ou de bobines produites par la présence d'un liquide ou d'un matériau solide fluent dans des champs électriques ou électromagnétiques en mesurant les variations de capacité de condensateurs
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
A lysis capsule for performing a cell lysis procedure includes a hollow body having an open first end and an open second end, a first porous membrane covering the open first end, and a second porous membrane covering the open second end, and the hollow body defines a lysis chamber between the first and second porous membranes. A plurality of non-magnetic beads and at least one magnetic element are disposed within the lysis chamber, and the pores of the first and second porous membranes are sized to retain the non-magnetic beads and the magnetic element within the lysis chamber. An internal control may be contained within the lysis chamber to validate an assay result and/or to validate the effectiveness of the cell lysis procedure. The lysis capsule may be disposed within a sample chamber of a fluidic cartridge.
Systems and corresponding methods transfer liquid sample from a first container having a cap with a sample collection swab coupled thereto to a second container having a cap without such sample collection swap coupled thereto. Other systems and corresponding methods remove a cap having no sample collection swab coupled thereto from a first container and remove a cap having a sample collection swab coupled thereto from a second container containing a liquid sample. The cap with the sample collection swab coupled thereto is then secured to the first container and the cap having no sample collection swap coupled thereto is then secured to the second container.
A magnetic resonant imaging (MRI) review workstation includes a control processor, and a display integrated or otherwise operatively coupled with the control processor, wherein the control processor is configured to receive and analyze magnetic resonant imaging information pertaining to an imaged volume of tissue, and to cause to be displayed on the display output information that reflects or is otherwise indicative of an absorption rate of a contrast agent in the volume of tissue.
G01R 33/56 - Amélioration ou correction de l'image, p. ex. par des techniques de soustraction ou d'établissement de moyenne
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiquesMesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p. ex. formation d'images par résonance magnétique
G01R 33/50 - Systèmes d'imagerie RMN basés sur la détermination des temps de relaxation
63.
FLUIDIC CARTRIDGE AND APPARATUSES FOR PROCESSING FLUIDIC CARTRIDGES
Controlling a syringe pump having an elastomeric stopper and a syringe plunger connected to the stopper includes operating a motor coupled to the plunger to move the syringe plunger and the stopper toward a bottom wall of a syringe barrel, monitoring a motor demand signal of the motor, detecting an inflection in the motor demand signal that indicates that the stopper has contacted the bottom wall of the syringe barrel, after detecting the inflection, continuing to operate the motor until the motor stalls, after detecting the inflection and until the motor stalls, counting encoder steps of an encoder coupled to the motor, operating the motor in a reverse direction for the counted number of encoder steps, continuing to operate the motor in the opposite direction to move the stopper to a predefined distance away from the bottom wall of the syringe to draw a predefined volume of fluid into the syringe barrel.
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
F04B 13/00 - Pompes spécialement modifiées pour débiter des quantités fixes ou prédéterminées
F04B 17/03 - Pompes caractérisées par leur combinaison avec des machines motrices ou moteurs particuliers qui les entraînent ou par leur adaptation à ceux-ci entraînées par des moteurs électriques
64.
METHODS AND COMPOSITIONS FOR AMPLIFYING AND/OR DETECTING ROTAVIRUS NUCLEIC ACIDS
Disclosed are nucleic acid oligomers, including amplification oligomers and detection probes, for detection of rotavirus target nucleic acid. Also disclosed are methods of specific nucleic acid amplification and detection using the disclosed oligomers, as well as corresponding formulations, reaction mixtures, and kits. Methods of synthesizing the nucleic acid oligomers are also disclosed.
C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
65.
Methods and Compositions for Detecting Candida Species
Disclosed are methods utilizing specific amplification of Candida sp. target nucleic acid for detecting the presence or absence of Candida sp. in a sample. Also disclosed are corresponding oligomers, including amplification oligomers, capture probes and detection probes, and combinations thereof, as well as corresponding reaction mixtures and kits.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p. ex. pour test de réaction en chaîne par polymérase [PCR]
C12Q 1/6876 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes
C12Q 1/6888 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes
C12Q 1/6895 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les plantes, les champignons ou les algues
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
66.
WASH SOLUTION AND METHOD TO REMEDIATE LUBRICANT CONTAMINATION
A wash solution is provided for use in removing a carbomer-based lubricant from a cytological specimen sample suspended in a collection preservative solution. The wash solution includes a tris-based alkaline buffer prepared in 20% methanol. The wash solution may include one or more compounds such as guanidine, one or more basic amino acids, or an arginine-rich protein such as protamine. The compounds interrupt the association between the carbomer-based lubricant and cell surface proteins.
A method is provided for processing a cytological specimen such as a Pap sample suspended in a collection preservative solution that is contaminated with a lubricant. The method includes the steps of adding one or more salts to the specimen in the collection preservative solution; and after adding the salt, preparing a microscope slide comprising cells from the specimen. The salts may be NaCl or CytoLyt® salts.
The invention pertains to a mechanism for performing capacitive level sensing of fluid within a fluid container supported on a movable carrier. The mechanism comprises a conductive probe configured for capacitive level sensing by detecting a signal or change of signal when the probe, or a conductive tip removably attached to the probe, contacts the surface of the fluid within the container. The signal or change of signal is based on electrical capacitance between the probe or conductive tip and a grounded, conductive structure adjacent to or contacting the container. The mechanism further comprises a probe position sensor for monitoring a vertical position of the probe and recording the vertical probe position at which the signal or detectable change of signal is detected. The mechanism further comprises a movable grounding element, configured for selective movement relative to a container positioned by the movable carrier at a level-sensing location with respect to the probe until the grounding element is in close proximity to or in contact with a portion of the container.
69.
ON-BOARD LYSIS, INTERNAL CONTROL, AND VOLUMETRIC EXPANSION IN A FLUIDIC CARTRIDGE
A fluidic cartridge chamber contains non-magnetic beads and a magnetic element. Motion imparted to the magnetic element by a varying magnetic field imparts motion the non-magnetic beads, thereby lysing cells of a fluid sample within the chamber. An internal control is provided within the chamber to validate an assay result and/or to validate the effectiveness of cell lysis. The internal control may be in a non-liquid form deposited on a portion of the chamber, the non-magnetic beads, and/or the magnetic element and dissolves when contacted by a fluid sample. The internal control may be provided in a pellet form that dissolves when contacted by a fluid sample or is disrupted when exposed to lysing forces of the non-magnetic beads. A fluidic cartridge includes wells that are fluidly connected, and one well comprises an expansion well to which a chamber expander is attached to expand a volumetric capacity of the expansion well.
A system and method for heating abiological sample includes, or employs, a housing defining a filter chamber with a fluid inlet and outlet and a filter assembly within the chamber. The filter assembly includes filter media and a conductive mesh and fluid sample flowing through the chamber passes through both the filter media and the mesh. The conductive mesh is inductively heated by an induction coil disposed outside the chamber adjacent to a wall of the housing. The filter chamber may be part of a fluid cartridge including one or more chambers for containing fluid sample and other process fluids or functional connections for connecting external receptacles containing fluid sample and other process fluids. A fluid flow network includes fluid channels and flow control valves for selectively controlling fluid flow within the cartridge and through the filter assembly within the chamber.
Methods, systems, reaction mixtures, kits, apparatuses, and systems for monitoring nucleic acid amplification reaction mixtures for abnormalities. Exemplary methods include determining fluorescence-based values from fluorophore-containing nucleic acid amplification reaction mixtures and determining whether those values satisfy predetermined values or indicate abnormalities.
Methods, systems, and computer readable media monitor for the introduction of one or more liquids into a reaction chamber. Exemplary methods include determining fluorescence-based values from fluorophore-containing nucleic acid amplification reaction mixtures and determining whether those values satisfy predetermined thresholds and/or ranges or otherwise indicate abnormalities.
C12Q 1/6848 - Réactions d’amplification d’acides nucléiques caracterisées par les moyens d’empêcher la contamination ou d’augmenter la spécificité ou la sensibilité d’une réaction d’amplification
73.
METHODS AND OLIGONUCLEOTIDE COMBINATIONS FOR DETECTING THE PRESENCE OF MONKEYPOX VIRUS (MPXV) IN A SAMPLE
The present invention is directed to a method for detecting the presence or absence of monkeypox virus (MPXV) in a biological sample, the method comprising: a) contacting the sample or nucleic acid extracted from said sample with reagents and an oligonucleotide combination capable of amplifying a target region of a monkeypox viral genome, wherein said oligonucleotide combination is selected from the group consisting of: i) a B7R oligonucleotide primer set specific for amplifying a target sequence in the B7R gene of the MPXV genome generating an MPXV amplification product comprising the sequence of SEQ ID NO:65; and ii) a G2R oligonucleotide primer set specific for amplifying a target sequence in the G2R gene of the MPXV genome generating an MPXV amplification product comprising the sequence of SEQ ID NO:63; b) performing an in vitro nucleic acid amplification reaction, wherein any MPXV nucleic acid present in the sample is used as a template to generate the MPXV amplification product corresponding to the oligonucleotide combination of i) or ii); and c) detecting the presence or absence of the MPXV amplification product generated in step b), wherein the presence of the MPXV amplification product is indicative of the presence of MPXV in the biological sample. The present invention also provides oligonucleotides which can be used in the method of the invention as primers and probes.
C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
Methods, systems, and computer readable media monitor fluorescence signals from a nucleic acid amplification reaction for abnormal fluorescence detection. Exemplary methods include determining fluorescence-based values from fluorophore-containing nucleic acid amplification reaction mixtures and determining whether those values satisfy predetermined thresholds and/or ranges or otherwise indicate abnormalities.
The invention pertains to a carrier support for holding a carrier, wherein the carrier is configured to hold a plurality of receptacles, wherein the carrier support is configured to be moveable between a first position and a second position, and wherein the carrier support comprises a carrier locking mechanism configured to lock the carrier with respect to the carrier support when the carrier support is moved to the second position and to release the carrier when the carrier support is moved to the first position to permit the carrier to be moved with respect to the carrier support when the carrier support is in the first position. The carrier locking mechanism comprises a pivoting latch configured to pivot with respect to the carrier support between a first position not engaged with a portion of the carrier and a second position engaged with a portion of the carrier, and a slide latch configured to translate linearly with respect to the carrier support between a first position not engaged with a portion of the carrier and a second position engaged with a portion of the carrier.
G01N 35/02 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet en utilisant une série de récipients à échantillons déplacés par un transporteur passant devant un ou plusieurs postes de traitement ou d'analyse
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
A tissue sealing and cutting instrument includes a jaw actuation handle movably coupled to the instrument body handle and configured to move a pair of opposing jaws disposed on a shaft extending from the instrument body from an open position to an approximate position for clamping tissue therebetween. A cutting member is disposed in the shaft in a retracted position, wherein the cutting member may be advanced distally to cut tissue clamped between the jaws by a cutting member translation assembly that includes a rack and pinion assembly mounted in the instrument body, wherein a portion of the jaw actuation handle interferes with and prevents rotation of the pinion, and corresponding distal advancement the cutting member, unless the jaw actuation handle is moved sufficiently towards the instrument body handle to move the pair of opposing jaws into the approximate position.
Disclosed herein are methods and systems for x-ray imaging a breast and a breast implant in the breast simultaneously, comprising positioning the breast and the breast implant on a support platform of an x-ray imaging system, wherein an x-ray detector is disposed below the support platform. A high-energy x-ray is emitted through the breast and the breast implant, wherein the high-energy x-ray delivers a high-energy x-ray dose to the breast, and wherein the high-energy x-ray dose does not exceed a prescribed dose. The high-energy x-ray is received at the x-ray detector. The high-energy x-ray received at the x-ray detector is processed to obtain a high-energy x-ray image of the breast and the breast implant, wherein the high-energy x-ray image comprises a breast tissue feature within an area of the x-ray image defined by the breast implant.
A61B 6/02 - Agencements pour établir un diagnostic dans des plans différents successifsDiagnostic stéréoscopique utilisant des radiations
A61B 6/04 - Mise en position des patientsLits inclinables ou similaires
A61B 6/00 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations
A61B 6/50 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations spécialement adaptés à des parties du corps spécifiquesAppareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations spécialement adaptés à des applications cliniques spécifiques
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
Produits et services
Specimen collection kit comprised of a reagent for scientific research purposes, and also comprising a cup, absorbent pad, and bag for collecting and transporting a biological sample Specimen collection kit comprised of a reagent for medical purposes, and also comprising a cup, absorbent pad, and bag for collecting and transporting a biological sample Scientific research specimen collection devices in the nature of a cup, absorbent pad, bag for the collection of a biological sample; laboratory filters; microscope slides; Downloadable medical software for examining biological samples Medical specimen collection devices in the nature of a cup and bag for the collection of a biological sample
79.
WIDE ANGLE AUTOMATIC EXPOSURE CONTROL IN TOMOSYNTHESIS
The present application discloses a system and method to calculate the automatic exposure control (AEC) calibrated dosage for tomosynthesis sweeps. For example, reference images may be acquired, and corresponding reference detector count maps may be generated and stored for a plurality of projection angles using the tomosynthesis imaging system. The tomosynthesis imaging system may then acquire a scout image using a scout dosage, identify the densest region within the scout image, and calculated the average detector count values associated with the densest region. The AEC calibrated dosage can be calculated based on a ratio of the average reference detector count values, corresponding to the detector count values of pixels with a corresponding densest region of the reference image, and the calculated average detector count values.
A61B 6/02 - Agencements pour établir un diagnostic dans des plans différents successifsDiagnostic stéréoscopique utilisant des radiations
A61B 6/00 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations
A61B 6/04 - Mise en position des patientsLits inclinables ou similaires
A61B 6/50 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations spécialement adaptés à des parties du corps spécifiquesAppareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations spécialement adaptés à des applications cliniques spécifiques
Disclosed are methods for isolating an analyte from a sample. In some aspects, the methods are for selectively isolating a microbial cell analyte, such as a nucleic acid, from a sample containing or suspected of containing mammalian cells. The selective isolation method includes selective lysis of the mammalian cells and filtration of the resulting lysate through a filter that retains intact microbial cells, followed by on-filter lysis of the retained microbial cells to release the microbial cell analyte. The released analyte is then eluted from the filter. In other aspects, the methods utilize on-filter lysis of a sample containing intact cells (e.g., microbial cells) to release the analytes, followed by elution of the released analytes from the filter by passing an immiscible liquid through the filter. The isolated analytes may be analyzed using a suitable assay depending on the type of analyte molecule. Also disclosed are fluidic systems and lysis solutions that may be used for isolating an analyte according to the disclosed methods.
C12N 9/36 - Hydrolases (3.) agissant sur les composés glycosyliques (3.2) agissant sur les liaisons bêta-1, 4 de l'acide N-acétylmuramique avec l'acétylamino-2 déoxy-2-D-glucose, p. ex. lysozyme
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
Produits et services
(1) Automated test instruments for in vitro specimen processing for laboratory use; specimen transfer instruments for laboratory use.
(2) Automated test instruments for in vitro specimen processing for medical use; specimen transfer instruments for medical use.
Methods and systems providing guidance for operation of a biopsy needle based on ultrasonic imaging. Ultrasonic waves are emitted and detected by a ultrasonic transducer to generate image data. A biopsy needle is identified within the generated image data, and the biopsy needle may be in a pre-fire configuration. Based on the identification of the biopsy needle, the methods and systems may determine a predicted location of the biopsy needle based at least in part on biopsy needle properties. The predicted location of the biopsy needle may be the predicated location of the biopsy needle in its post-fire configuration. At least one indicator may be displayed indicating the determined predicted location.
A61B 34/20 - Systèmes de navigation chirurgicaleDispositifs pour le suivi ou le guidage d'instruments chirurgicaux, p. ex. pour la stéréotaxie sans cadre
A61B 8/00 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores
A61B 34/00 - Chirurgie assistée par ordinateurManipulateurs ou robots spécialement adaptés à l’utilisation en chirurgie
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures
G01S 7/52 - Détails des systèmes correspondant aux groupes , , de systèmes selon le groupe
G01S 15/89 - Systèmes sonar, spécialement adaptés à des applications spécifiques pour la cartographie ou la représentation
G16H 10/40 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données relatives aux analyses de laboratoire, p. ex. pour des analyses d’échantillon de patient
G16H 20/40 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des thérapies mécaniques, la radiothérapie ou des thérapies invasives, p. ex. la chirurgie, la thérapie laser, la dialyse ou l’acuponcture
G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p. ex. l’édition
G16H 40/63 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement local
A system includes two or more illuminators, each illuminator configured to provide excitation light. An excitation waveguide is coupled to each of the illuminators. Each of the excitation waveguides is configured to guide the excitation light from the coupled illuminator to a corresponding location, thereby illuminating at least a portion of the location with the excitation light. A combined-emission waveguide is configured to guide light emitted from the illuminated locations to detection optics. The detection optics include one or more lenses. The detection optics are configured to receive at least a portion of the emitted light provided from the combined-emission waveguide and direct at least a first portion of the received emitted light along a first detection path based on a first wavelength of the received emitted light.
Methods, apparatuses, and systems are provided for processing a biological sample. Exemplary methods comprise transferring a swab associated with an aliquot of the biological sample into a sample transport media. The methods can provide efficient transfer of a target material such as cells or nucleic acid into the sample transport media for extraction, amplification, and detection of the target material.
C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p. ex. pour test de réaction en chaîne par polymérase [PCR]
C12N 9/54 - Protéinases provenant de bactéries les bactéries étant du genre Bacillus
C12Q 1/37 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une hydrolase faisant intervenir une peptidase ou une protéinase
An implantable tissue marker device is provided to be placed in a soft tissue site through a surgical incision. The device can include a bioabsorbable body in the form of a spiral and defining a spheroid shape for the device, the spiral having a longitudinal axis, and turns of the spiral being spaced apart from each other in a direction along the longitudinal axis. A plurality of markers can be disposed on the body, the markers being visualizable by a radiographic imaging device. The turns of the spiral are sufficiently spaced apart to form gaps that allow soft tissue to infiltrate between the turns and to allow flexibility in the device along the longitudinal axis in the manner of a spring.
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux
A dual-energy X-ray absorptiometry (“DXA”) system includes an x-ray source assembly comprising a source carriage to move the x-ray source assembly along a scan path, the scan path comprising an active scan portion and a reference measurement portion. A detector assembly including a detector carriage to move the detector assembly with the source assembly and to collect scan data at active scan portions. A support structure supporting the source and detector assemblies. A calibration controller coupled a calibration element having a known x-ray attenuation value and configured position the calibration element between the source and detector assemblies during the reference measurement portion and to remove the calibration element from between the source and detector assemblies during the active scan portion. A processing unit operable to compare the reference measurement against an expected reference value to identify a variance and to selectively trigger an action in response to the variance.
A61B 6/00 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations
A61B 6/02 - Agencements pour établir un diagnostic dans des plans différents successifsDiagnostic stéréoscopique utilisant des radiations
Systems and methods for improving radiographic scanning. In an example, the technology relates to a system for performing radiographic scanning. The system includes a photon source configured to emit photons. The system also includes a photon counting detector for detecting photons emitted from the photon source after passing through a target. The photon counting detector comprising first pixels having a first size and second pixels having a second size, and the first size is greater than the second size.
G01T 1/29 - Mesure effectuée sur des faisceaux de radiations, p. ex. sur la position ou la section du faisceauMesure de la distribution spatiale de radiations
Systems and methods for risk-based breast cancer screening. The breast cancer screening techniques can identify and monitor women who may otherwise later be diagnosed with symptomatic and/or later-stage breast cancer. A personalized breast CAD and health-tracking system is provided that can differentiate pathological changes from normal changes in breast tomosynthesis images. A breast progression predictor can be a generative model that receives input breast images including past images captured at a past timepoint and current images captured at a current timepoint. The model uses the past images to generate predicted images for the current timepoint. Differences between the predicted images and the current images can be used to determine a likelihood of pathological change in the current images. When a pathological change is detected. The system can incorporate a broad spectrum of patient non-image information to further enhance and personalize the prediction of breast progression.
Systems and methods for risk-based breast cancer screening. The breast cancer screening techniques can identify and monitor women who may otherwise later be diagnosed with symptomatic and/or later-stage breast cancer. A personalized breast CAD and health-tracking system is provided that can differentiate pathological changes from normal changes in breast tomosynthesis images. A breast progression predictor can be a generative model that receives input breast images including past images captured at a past timepoint and current images captured at a current timepoint. The model uses the past images to generate predicted images for the current timepoint. Differences between the predicted images and the current images can be used to determine a likelihood of pathological change in the current images. When a pathological change is detected. The system can incorporate a broad spectrum of patient non-image information to further enhance and personalize the prediction of breast progression.
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
Disclosed are formulations, including both liquid and lyophilized formulations, comprising a far-red dye probe and a non-linear surfactant or foamban. Also disclosed are related methods for preparing a lyophilized far-red dye probe formulation as well as related kits and diagnostic products.
C12Q 1/6818 - Tests d’hybridation caractérisés par les moyens de détection impliquant l’interaction de plusieurs marqueurs, p. ex. transfert d’énergie de résonance
C09B 23/08 - Colorants méthiniques ou polyméthiniques, p. ex. du type cyanine caractérisés par la chaîne méthinique contenant un nombre impair de groupes CH plus de trois groupes CH, p. ex. polycarbocyanines
C12Q 1/6876 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
Produits et services
Diagnostic reagents for scientific purposes; buffer solutions for scientific purposes; diagnostic preparations for research laboratory use Diagnostic kits comprised of assays for testing of bodily fluids for use in disease detection; diagnostic kits comprising primarily diagnostic agents, preparations and substances for medical purposes; diagnostic kits comprised of medical diagnostic reagents; medical diagnostic reagents and assays for testing of body fluids; diagnostic agents, preparations and substances for medical purposes Scientific apparatus for diagnostic testing of biological samples, other than for medical purposes; research laboratory analyzers for measuring, testing and analyzing blood and other bodily fluids; diagnostic apparatus for research laboratory use for processing samples; diagnostic apparatus for the detection of pathogens, not for medical purposes; downloadable medical software for processing biological samples Scientific apparatus for diagnostic testing of biological samples, for medical purposes; diagnostic instruments for medical purposes used for analyzing body fluids; medical diagnostic apparatus for testing pathogens; medical diagnostic apparatus for testing of biological samples incorporating recorded software for processing the biological samples; medical diagnostic apparatus for testing biological samples incorporating recorded operating system software
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
Produits et services
Diagnostic reagents for scientific purposes; Diagnostic preparations for research laboratory use; buffer solutions for scientific purposes Diagnostic kits comprised of assays for testing of bodily fluids for use in disease detection; diagnostic kits comprising primarily diagnostic agents, preparations and substances for medical purposes; diagnostic kits comprised of medical diagnostic reagents; medical diagnostic reagents and assays for testing of body fluids; diagnostic agents, preparations and substances for medical purposes Scientific apparatus for diagnostic testing of biological samples, other than for medical purposes; research laboratory analyzers for measuring, testing and analyzing blood and other bodily fluids; diagnostic apparatus for the detection of pathogens, not for medical purposes; downloadable medical software for processing biological samples; diagnostic apparatus for research laboratory use for processing samples Scientific apparatus for diagnostic testing of biological samples, for medical purposes; diagnostic instruments for medical purposes used for analyzing body fluids; medical diagnostic apparatus for testing pathogens; medical diagnostic apparatus for testing of biological samples incorporating recorded software for processing the biological samples; medical diagnostic apparatus for testing biological samples incorporating recorded operating system software
A method of sample processing that includes a step of prompting, at a user interface of a sample processing instrument, a user to enter a user input based on first information transmitted from an RFID transponder disposed on a receptacle holder within the sample processing instrument. The user input indicates second information about the receptacle holder. The method of sample processing further includes a step of receiving, at the user interface of the sample processing instrument, the user input. The Method of sample processing further includes a step of processing, using the sample processing instrument, a sample based on the user input.
B01L 9/00 - Dispositifs de supportDispositifs de serrage
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
G01F 23/26 - Indication ou mesure du niveau des liquides ou des matériaux solides fluents, p. ex. indication en fonction du volume ou indication au moyen d'un signal d'alarme en mesurant des variables physiques autres que les dimensions linéaires, la pression ou le poids, selon le niveau à mesurer, p. ex. par la différence de transfert de chaleur de vapeur ou d'eau en mesurant les variations de capacité ou l'inductance de condensateurs ou de bobines produites par la présence d'un liquide ou d'un matériau solide fluent dans des champs électriques ou électromagnétiques
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
98.
SYSTEMS FOR DIFFERENTIAL MEASUREMENT OF A FLUID LEVEL IN A SAMPLE RECEPTACLE
Automated systems determine a level of fluid relative to a rim of a sample receptacle defining an open top of the sample receptacle. The systems utilize a distance sensor to measure the distance between the rim of the sample receptacle and the surface of a fluid sample contained in the sample receptacle, where at least one of the sensor and the sample receptacle is moved relative to the other to enable the sensor to obtain a sequence of discrete measurements of distances between the sensor and the rim of the sample receptacle and between the sensor and the surface of the fluid sample. A controller processes an output signal from the sensor to determine a level of the fluid relative to the rim of the sample receptacle. The derivative of the sequence of discrete measurements may be used to identify the rim and the fluid surface in the output signal.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
G01N 35/02 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet en utilisant une série de récipients à échantillons déplacés par un transporteur passant devant un ou plusieurs postes de traitement ou d'analyse
99.
X-RAY MAMMOGRAPHY AND/OR BREAST TOMOSYNTHESIS USING A COMPRESSION PADDLE
An x-ray breast imaging system comprising a compression paddle in which the compression paddle comprises a front wall and a bottom wall. The front wall is configured to be adjacent and face a chest wall of a patient during imaging and the bottom wall configured to be adjacent a length of a top of a compressed breast. The bottom wall extends away from the patient's chest wall, wherein the bottom wall comprises a first portion and a second portion such that the second portion is between the front wall and the first portion. The first portion is generally non-coplanar to the second portion, wherein the compression paddle is movable along a craniocaudal axis. The x-ray breast imaging system also comprises a non-rigid jacket releasably secured to the compression paddle, the non-rigid jacket positioned between the compression paddle and the patient.
A61B 6/04 - Mise en position des patientsLits inclinables ou similaires
A61B 6/02 - Agencements pour établir un diagnostic dans des plans différents successifsDiagnostic stéréoscopique utilisant des radiations
A61B 6/50 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations spécialement adaptés à des parties du corps spécifiquesAppareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations spécialement adaptés à des applications cliniques spécifiques
100.
HORIZONTALLY-DISPLACEABLE FOAM BREAST COMPRESSION PADDLE
A breast compression paddle includes a bracket, a rigid substrate, and a foam compressive element. The bracket removably secures the breast compression paddle to an imaging system. The rigid substrate is secured to the bracket and includes a first edge and a second edge disposed opposite the first edge. The foam compressive element is slidably secured to the rigid substrate.
A61B 6/04 - Mise en position des patientsLits inclinables ou similaires
A61B 6/00 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations
A61B 6/50 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations spécialement adaptés à des parties du corps spécifiquesAppareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations spécialement adaptés à des applications cliniques spécifiques
