RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY (République de Corée)
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Bae, Yoe Sik
Yun, Nam Joo
Cho, Hyeon Jin
Choi, Soo Hyuk
Yoon, Hye Rim
Choi, Hee Won
Seo, Eun Jin
Abrégé
The present invention relates to a WKYMVm peptide analog comprising an amino acid sequence of Trp (W)-Lys (K)-Tyr (Y)-Met (M)-Val (V)-D-Met (m), in which at least one amino acid residue selected from the group consisting of Lys (K), Tyr (Y), and Met (M) in the amino acid sequence is substituted with a β3-amino acid residue or a peptoid residue, and a use thereof. The WKYMVm peptide analogs of the present invention has effects of increasing stability by increasing in vivo degradation half-life and of promoting activation of innate immune responses by neutrophils through activation of formyl peptide receptors, and thus can be effectively used in preventing or treating a disease that is be prevented or treated by formyl peptide receptors, especially an infectious disease or inflammatory disease.
Industry-Academic Cooperation Foundation, Yonsei University (République de Corée)
Inventeur(s)
Kim, Baek Gil
Cho, Nam Hoon
Jang, Yeonsue
Kang, Suki
Abrégé
The present invention provides an endoscopic pipette and an observation system, the endoscopic pipette is configured to remove a culture medium accommodated in a culture vessel, in which spheroids are cultured, and observe the spheroids in the culture vessel, and the endoscopic pipette includes a tip unit configured to be inserted into the culture vessel to extract the culture medium, an accommodation unit configured to accommodate the culture medium extracted by the tip unit, a camera unit provided between the tip unit and the accommodation unit, disposed adjacent to the tip unit, and configured to capture an image of an interior of the culture vessel, and a power unit provided in a partial space of the accommodation unit and configured to provide power to the camera unit.
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Hong, Jinkee
Abrégé
The present disclosure relates to a cell obtaining method for creating NFT based on a cell image. The cell obtaining method includes the steps of separating a cell from a biological sample, obtaining a stem cell by treating the cell with a dedifferentiation inducer, differentiating the stem cell, acquiring an image of the differentiated cell; and converting the image of the differentiated cell into an NFT image, and creates the NFT using a vital image in a simple and easy way through non-invasive and non-medical procedures.
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Kim, Hye Ryun
Lee, In Suk
Ha, Sang Jun
Cha, Jun Ha
Koh, Yoon Woo
Abrégé
KLRB1KLRB1 mRNA or a protein encoded by the mRNA or CD161+ tissue-resident memory T cells as a marker for predicting a response to immunotherapy in HPV-induced cancer.
G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer
C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
C12Q 1/6881 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour le typage de tissu ou de cellule, p. ex. sondes d’antigène leucocytaire humain [HLA]
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
5.
DNA CLOCKS CAPABLE OF LONG-TERM TIMEKEEPING COMPRISING A COMPOSITION FOR MEASURING OR PREDICTING THE DURATION OF CELLULAR EVENTS IN CELLS
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Kim, Hyongbum
Park, Ji-Hye
Lee, Hanahrae
Abrégé
Disclosed are a DNA clock capable of recording long periods of time, comprising a composition for measuring or estimating elapsed time in cells, and a method of measuring or estimating elapsed time in cells using the composition.
C12Q 1/6897 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques faisant intervenir des gènes rapporteurs liés de façon fonctionnelle à des promoteurs
C12Q 1/6811 - Méthodes de sélection pour la production ou l’élaboration d’oligonucléotides spécifiques cibles ou de molécules de liaison
C12Q 1/6874 - Méthodes de séquençage faisant intervenir des réseaux d’acides nucléiques, p. ex. séquençage par hybridation [SBH]
Industry-Academic Cooperation Foundation, Yonsei University (République de Corée)
Inventeur(s)
Kang, Seok-Gu
Sung, Hak-Joon
Baek, Sewoom
Abrégé
This application relates to a tumor tissue model in which tumor tissue isolated from a patient can be cultured. The tumor tissue model uses tumor tissue isolated from a patient, and thus the tumor tissue can be cultured while maintaining the extracellular matrix of tumor cells. Since the tumor tissue is cultured in an environment similar to the actual environment inside the body, the tumor tissue model can be used for patient-tailored drug screening, drug response evaluation, radiation reactivity evaluation, tumor-related research, clinical evaluation, animal replacement tests, disease modeling, etc.
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Kim, Je Min
Lee, Ju Hee
Kim, Ji Hee
Lee, Yun Na
Park, Chang Ook
Oh, In Rok
Choi, Ye Seul
Abrégé
The present invention relates to a method by which a processor of a Demodex folliculorum prediction device provides information about Demodex folliculorum, and provides a method for providing information about Demodex folliculorum, and a device based thereon, the method comprising the steps of: receiving a face image of an individual; acquiring, as one or more patches, regions of interest in the face from the received face image; inputting the face image and each of the patches into a plurality of first density prediction models trained to input the face image and each of the patches so as to predict the density probability of Demodex folliculorum, thereby making a first prediction about the density probability of Demodex folliculorum for the face image and each of the patches; and inputting the density probability of Demodex folliculorum for the face image and each of the patches into a single second density prediction model trained to input the density probability of a plurality of Demodex folliculorums so as to predict the density probability of Demodex folliculorum for an individual, thereby making a second prediction about the density probability of the final Demodex folliculorum.
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
G16H 30/20 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le maniement d’images médicales, p. ex. DICOM, HL7 ou PACS
G06N 20/20 - Techniques d’ensemble en apprentissage automatique
8.
MANAGEMENT SYSTEM FOR GENERATING AND DISTRIBUTING CELL IMAGE-BASED NFT
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Hong, Jinkee
Abrégé
The present disclosure relates to a management system for generating and distributing a cell image-based NFT including a cell image generation unit that generates an image from a collected cell, an NFT issuance unit that converts the cell image into an NFT image and stores and manages the NFT image, and an NFT transaction unit that brokers an online transaction for the issued NFT, and a service providing method thereof, and may assign an asset value to a vital image to meet the demand for owning the image.
G06V 20/69 - Objets microscopiques, p. ex. cellules biologiques ou pièces cellulaires
G06F 21/10 - Protection de programmes ou contenus distribués, p. ex. vente ou concession de licence de matériel soumis à droit de reproduction
H04L 9/32 - Dispositions pour les communications secrètes ou protégéesProtocoles réseaux de sécurité comprenant des moyens pour vérifier l'identité ou l'autorisation d'un utilisateur du système
9.
COMPOSITION FOR FIXATIVE EXCHANGE OF PFA-FIXED OR FFPE-TREATED BIOLOGICAL SAMPLES, AND METHOD THEREFOR
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Sohn, Chang Ho
Park, Han Eol
Lee, Yu Tak
Abrégé
The present invention relates to a composition for fixative exchange, comprising an organic catalyst and a platinum-based cross-linking agent. The composition of the present invention allows site-selective binding without interfering with Watson-Crick base pairs of nucleic acids and allows nucleic acids having reacted with a fixative to be restored to the state before reacting with the fixative, thereby enabling reverse transcription efficiency to be maximized, and thus can be effectively used in the field of diagnosing diseases or discovering a target material for new drug development through transcriptome analysis or multi-omics analysis from a single cell or a single nucleus.
Industry-Academic Cooperation Foundation, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Cho, Seung Woo
Jin, Yoon Hee
Choi, Yi Sun
Park, Eun Ju
Abrégé
A composition comprising a decellularized uterine tissue-derived extracellular matrix and a use thereof and, more specifically, a hydrogel composition for three-dimensional culturing an endometrial organoid, a preparation method therefor, and a use thereof are described. The hydrogel composition comprising a decellularized uterine tissue-derived extracellular matrix can be utilized to fabricate an endometrial organoid highly similar to in vivo uterine tissues and organs through the properties, components, and physical properties of the decellularized uterine tissue-derived extracellular matrix, and such endometrial organoids can be advantageously used for in-vivo implantation and in drug tests for various uterus-related diseases.
C12N 5/071 - Cellules ou tissus de vertébrés, p. ex. cellules humaines ou tissus humains
C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p. ex. lignées cellulairesTissusLeur culture ou conservationMilieux de culture à cet effet
11.
MANUFACTURING METHOD FOR EUGENOL-INCORPORATED FRAGRANCE MICROCAPSULE COMPOSED OF POLYHYDROALKANOATES
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Park, Moo Suk
Lee, Sang Guk
Kim, Hey Soo
Abrégé
Provided herein are a method for providing information on recovery from acute kidney injury and a kit therefor, the method including the steps of: measuring a level of at least one amino acid of glutamine, glutamic acid, arginine, and tryptophan at a predetermined time with respect to a biological sample isolated from an individual; and determining whether there is a possibility of recovery from acute kidney injury (AKI) for the individual within a predetermined period of time on the basis of the measured level of amino acids.
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
G01N 33/70 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir la créatine ou la créatinine
13.
SMALL DNA CLOCKS COMPRISING A COMPOSITION FOR MEASURING OR PREDICTING THE DURATION OF CELLULAR EVENTS IN CELLS
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Kim, Hyongbum
Park, Ji-Hye
Lee, Hanahrae
Abrégé
Please enter in the present application the English translation of the abstract of the Korean language application that was filed in the USPTO on Jun. 12, 2024, as contained in the English translation of the application in Appendix B of the Translator Certificate filed herewith, and as separately filed herewith in .docx format (728_Patent_Application_ABSTRACT.docx).
C12N 15/11 - Fragments d'ADN ou d'ARNLeurs formes modifiées
C12Q 1/44 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une hydrolase une estérase
14.
GLUCOSE MONITORING SENSOR OF VOLTAGE MEASUREMENT TYPE INCLUDING A SUPERCAPACITOR AND A CONTINUOUS MEASUREMENT METHOD OF GLUCOSE USING THE SAME
Industry-Academic Cooperation Foundation, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Park, Jin Woo
Kil, Hye Jun
Abrégé
A voltage measurement type glucose sensor comprises a microneedle array including a flat part and a plurality of microneedles located on one surface of the flat part; an enzyme layer located on a surface of the plurality of microneedles and including glucose oxidase; a supercapacitor located on the other side of the flat part; and a wireless communication module electrically connected to the supercapacitor, and a glucose measurement method using the same. The glucose sensor is self-driving without the need to apply separate external power, improving the lifespan of the device and enabling close monitoring of accurate glucose levels in real time,
A61B 5/145 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 5/1486 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang en utilisant des procédés chimiques ou électrochimiques, p. ex. par des moyens polarographiques en utilisant des électrodes enzymatiques, p. ex. avec oxydase immobilisée
15.
NOVEL GENE THAT REGULATES BLOOD-BRAIN BARRIER PASSAGE OF CRYPTOCOCCUS NEOFORMANS AND USE THEREOF
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
AMTIXBIO CO., LTD. (République de Corée)
Inventeur(s)
Bahn, Yong Sun
Yu, Seong Ryong
Lee, Kyung Tae
Lee, Jong Seung
Abrégé
The present invention relates to a method for screening for an inhibitor against the blood-brain barrier passage of Cryptococcus neoformans, a method for screening for an antifungal agent, and an antifungal composition. The screening method of the present invention uses a novel gene that regulates the blood-brain barrier passage of Cryptococcus neoformans, and thus can effectively screen for an inhibitor against blood-brain barrier passage and an antifungal agent.
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Kim, Han Sang
Kim, Kyung-A
Ahn, Joong Bae
Paik, Soon Myung
Yong, Dong Eun
Lee, Hyukmin
Abrégé
Provided are: a peptide targeting Fusobacteria, comprising a peptide consisting of an amino acid sequence selected from the group consisting of SEQ ID NOs: 77 to 83; a composition for diagnosing cancer, comprising same; and a drug delivery composition. The peptide targeting Fusobacteria accurately targets Fusobacteria, which are harmful bacteria in various diseases, including cancer, and thus can be effectively used in cancer diagnosis and drug delivery.
G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer
C12N 7/00 - Virus, p. ex. bactériophagesCompositions les contenantLeur préparation ou purification
G01N 33/569 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour micro-organismes, p. ex. protozoaires, bactéries, virus
17.
ORGANIC MATERIAL FOR SEMICONDUCTOR CMP, AND SLURRY COMPOSITION COMPRISING SAME
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Kim, Byeong-Su
Abrégé
Provided in one embodiment of the present invention is a polymer micelle having a micelle structure composed of an amphiphilic material with both a hydrophilic group and a hydrophobic group, wherein the hydrophilic group includes a polyglycerol functional group, and the hydrophobic group includes a phenol group having a hydrophobic substituent bonded to the end thereof and modified to be hydrophobic.
C07C 41/03 - Préparation d'éthers à partir d'oxiranes par réaction d'un cycle oxirane avec un groupe hydroxyle
C07C 43/23 - Éthers une liaison sur l'oxygène de la fonction éther étant sur un atome de carbone d'un cycle aromatique à six chaînons contenant des groupes hydroxyle ou O-métal
18.
SYSTEM FOR REDUCING NOISE OF CBCT IMAGE AND METHOD THEREFOR
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Lee, Joon Sang
Choi, Yoon Jeong
Ryu, Susie
Kim, Jun Hong
Abrégé
The present invention relates to a system for reducing noise of a CBCT image and a method therefor, wherein the system can reduce noise of a CBCT image by applying the difference between the CBCT image and a CT image to artificial intelligence learning by using CYCLE GAN so as to convert CBCT image data such that it has the same standards as CT image data and provide same, the CBCT image data having low quality and more noise than the CT image data.
A61B 6/00 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations
Industry-Academic Cooperation Foundation, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Park, Gyo Khang
Sohn, Il
Abrégé
In an embodiment, gas emitted during DRI processing and melting is collected and blown in refining, and gas emitted from the refining is collected and used in DRI processing, so that it is possible to circulate gas input to and emitted from each process in a DRI-Smelter-BOF (Basic Oxygen Furnace) scheme and achieve process optimization.
Industry-Academic Cooperation Foundation, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Park, Gyo Khang
Sohn, Il
Abrégé
An embodiment provides a method and a system device for refining molten iron, wherein hydrogen reduction DRI is utilized to collect CO2 gas generated during melting and further reduction and use the gas in decarbonization refining, so as to optimize processes and achieve carbon neutrality. In addition, it is possible to predict the end point of the decarbonization refining by measuring the amount of CO gas generated in decarbonization refining.
Industry-Academic Cooperation Foundation, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Park, Hyung Ho
Kim, Min Jae
Kim, Dong Eun
Kim, Geon Woo
Abrégé
Provided is a Mott-piezo memristor of an ABO3/CO composition, which has maximized piezo characteristics by using a method, such as doping, with various elements, an ABO3 material having a perovskite structure exhibiting Mott-transition characteristics, and inserting a CO interlayer. The Mott-piezo memristor may comprise: a bottom electrode; a top electrode arranged to face the bottom electrode; and a plurality of Mott layers and a plurality of piezoelectric layers, which are arranged between the bottom electrode and the top electrode, wherein the plurality of piezoelectric layers are arranged between the plurality of Mott layers
H10N 70/00 - Dispositifs à l’état solide n’ayant pas de barrières de potentiel, spécialement adaptés au redressement, à l'amplification, à la production d'oscillations ou à la commutation
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Lee, Hyungsuk
Cho, Seung-Woo
Kang, Byungjun
Shin, Jisoo
Rhyou, Chanryeol
Abrégé
Present disclosure provides an apparatus for manufacturing an artificial tissue, comprising:
a hydrogel accommodating structure which accommodates hydrogel including cells and has a bottom plate, a container and a cover; and a standing wave adding means for adding a standing wave to the hydrogel accommodated in the hydrogel accommodating structure, wherein cells in the hydrogel are aligned by the adding of a standing wave, and the position of the cells in the hydrogel is controlled by adjusting at least one of the attenuation coefficient of the container and the reflection coefficient of the cover.
C12M 1/42 - Appareils pour le traitement de micro-organismes ou d'enzymes au moyen d'énergie électrique ou ondulatoire, p. ex. magnétisme, ondes sonores
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
C12M 1/12 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens de stérilisation, filtration ou dialyse
C12M 3/00 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus
23.
COMPOSITION FOR PREVENTION OR TREATMENT OF ATOPIC DERMATITIS COMPRISING AKT SIGNALING PATHWAY INHIBITOR AS ACTIVE INGREDIENT
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Park, Chang Ook
Kim, Yu Ri
Kim, Su Min
Kim, Hye Li
Zhang, Kelun
Abrégé
The present invention relates to a composition for preventing or treating inflammatory or autoimmune skin disease. The composition of the present invention may be useful as a fundamental therapeutic composition that is able to efficiently ameliorate skin tissue damage caused by inflammation while having a minimized impact on systemic immune activity by specifically inhibiting the activity of skin-specific T cells. The present invention also provides a screening method capable of quickly and highly reliably identifying promising therapeutic candidates that are able to alleviate various autoimmune and inflammatory damages occurring in skin tissue by inhibiting the activity of skin-specific T cells.
A61K 31/517 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime condensées en ortho ou en péri avec des systèmes carbocycliques, p. ex. quinazoline, périmidine
A61K 8/49 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant des composés hétérocycliques
A61P 17/00 - Médicaments pour le traitement des troubles dermatologiques
A61Q 17/00 - Préparations protectricesPréparations employées en contact direct avec la peau pour protéger des influences extérieures, p. ex. des rayons du soleil, des rayons X ou d'autres rayons nuisibles, des matériaux corrosifs, des bactéries ou des piqûres d'insectes
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
24.
HIGHLY SENSITIVE SELF-POWERED PRESSURE SENSOR AND THE USE OF THE SAME
Industry-Academic Cooperation Foundation, Yonsei University (République de Corée)
Inventeur(s)
Park, Jin-Woo
Lee, Soyeon
Abrégé
Provided is a self-powered pressure sensor which may show excellent pressure sensitivity by significantly improving transfer efficiency of charges generated by triboelectrification, the sensor including: a first electrode; a first triboelectrification unit positioned on the first electrode; a second triboelectrification unit including a pattern on which a microstructure is repeatedly positioned, the microstructure being reversibly in contact with or separated from the first triboelectrification unit by a physical external force, and having at least one surface in contact with the first triboelectrification unit to induce a change in a contact area; and a second electrode positioned inside the second triboelectrification unit and conformally positioned on a surface of the microstructure, wherein the first electrode and the second electrode are geometrically asymmetric to each other.
A61B 5/024 - Mesure du pouls ou des pulsations cardiaques
A61B 5/0245 - Mesure du pouls ou des pulsations cardiaques utilisant des capteurs engendrant des signaux électriques
G01H 17/00 - Mesure des vibrations mécaniques ou des ondes ultrasonores, sonores ou infrasonores non prévue dans les autres groupes de la présente sous-classe
25.
PHOTOBIOLOGICAL HYDROGEN PRODUCTION METHOD BASED ON CELL ENGINEERING
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Ahn, Hyun Seo
Ryu, Won Hyoung
Gwon, Hyo Jin
Yun, Jae Hyoung
Abrégé
The present invention pertains to: an engineered cell comprising a chloroplast-containing cell and a conductor inserted into the cell, wherein the conductor is inserted so as to contact or penetrate the thylakoid membrane of the chloroplast, whereby the engineered cell is engineered so that photosynthetic electrons can be extracted out of the cell by light; a metal catalyst using the engineered cell; and a hydrogen production method using the engineered cell. By using the metal catalyst according to the present invention, oxygen generated during photosynthesis can be catalyzed and self-regulated at a low concentration and protons can be catalyzed to provide a hydrogen production system and method that enable sustained hydrogen production. In addition, the present invention has the effect of providing an artificial photosynthesis system which can convert sunlight into fuel by consuming only CO2 and water as electron sources and is especially superior in terms of cost efficiency and the immediate availability of the produced fuel.
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Lee, Eun Jig
Kim, Daham
Abrégé
The present invention relates to an autoimmune disease animal model and a method for preparing the same. The animal model of the present invention efficiently generates an autoantibody that causes autoimmune disease, by introducing an autoantigen-encoding gene through the Cre-LoxP system, which enables stable and continuous expression of the autoantigen at a desired time by treatment of Cre recombinase. Contrary to the conventional method that fails to effectively produce autoantibody due to leaky expression and immune tolerance, or requires repeated administration over several weeks, the present invention achieves sustainable expression of an effective amount of autoantigen by only one TAT-Cre recombinase treatment, thus may be utilized as an outstanding animal model reproducing various symptoms and molecular mechanisms of autoimmune diseases.
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Kim, Byeong-Su
Abrégé
An embodiment of the present invention provides a method for mechanochemical decomposition of polyvinyl chloride (PVC) using ball milling, the method comprising the steps of: ball milling PVC and a dechlorinating agent to obtain dechlorinated PVC; ball milling the dechlorinated PVC and an epoxidizing agent to obtain epoxidized PVC; and hydrolyzing the epoxidized PVC.
C08J 11/26 - Récupération ou traitement des résidus des polymères par coupure des chaînes moléculaires des polymères ou rupture des liaisons de réticulation par voie chimique, p. ex. dévulcanisation par traitement avec une substance organique par traitement avec des composés organiques contenant de l'oxygène contenant des groupes acide carboxylique, leurs anhydrides ou esters
C08F 236/04 - Copolymères de composés contenant plusieurs radicaux aliphatiques non saturés et l'un au moins contenant plusieurs liaisons doubles carbone-carbone le radical ne contenant que deux doubles liaisons carbone-carbone conjuguées
28.
PYRIMIDINE DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING CANCER COMPRISING SAME AS ACTIVE INGREDIENT
KOREA RESERARCH INSTITUTE OF CHEMICAL TECHNOLOGY (République de Corée)
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Lee, Kwangho
Duggirala, Krishna Babu
Choi, Gil Don
Chae, Chong Hak
Jung, Myoung Eun
Lee, Yujin
Cho, Byoung Chul
Abrégé
A pyrimidine derivative, a method for preparing the pyrimidine derivative, and a pharmaceutical composition comprising the pyrimidine derivative are disclosed. Also disclosed is a method for preventing or treating cancer which includes administering the pyrimidine derivative or a composition containing the pyrimidine derivative to a subject in need of cancer treatment or prevention. The pyrimidine derivative exhibits a high inhibitory ability against EGFR mutation and HER2 mutation, and thus can be effectively used in treatment of cancer in which EGFR mutation and HER2 mutation have occurred
A61K 31/505 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime
A61K 31/506 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime non condensées et contenant d'autres hétérocycles
A61K 31/5377 - 1,4-Oxazines, p. ex. morpholine non condensées et contenant d'autres hétérocycles, p. ex. timolol
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
C07D 401/12 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 401/14 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant au moins trois hétérocycles
C07D 403/12 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 417/12 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre et d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
29.
CONVERSION DEVICE FOR CONVERTING TREATMENT BEAM FOR TREATING LESION OF SUBJECT
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
SAMSUNG LIFE PUBLIC WELFARE FOUNDATION (République de Corée)
Inventeur(s)
Lim, Young Kyung
Kim, Myeong Soo
Park, Kyeong Yun
Kim, Do Hyeon
Kim, Sang Soo
Kim, Hak Soo
Jeong, Jong Hwi
Lee, Se Byeong
Shin, Dong Ho
Kim, Joo Young
Kim, Tae Hyun
Moon, Seong Ho
Suh, Yang-Gun
Kim, Hojin
Jo, Kwanghyun
Abrégé
The present invention relates to a conversion device for converting a treatment beam for treating a lesion of a subject, comprising: a collimator unit to which the treatment beam is incident and which has a plurality of slits; and a scattering unit that scatters the treatment beam that has passed through the collimator unit.
Industry-Academic Cooperation Foundation, YONSEI UNIVERSITY (République de Corée)
THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION (République de Corée)
Inventeur(s)
Kim, Jong Baeg
Koh, Dae Yeon
Jung, Yo Han
Han, Hyun Jun
Joo, Young Hoon
Kim, Hyun Bum
Abrégé
A system for determining a sputum type using a respiratory sound according to an embodiment may comprise a data collection unit that collects respiratory sound data from a patient who has undergone tracheostomy; an image conversion unit that receives the respiratory sound data collected by the data collection unit and converts the received respiratory sound data into a spectrogram image; and a sputum type determination unit that determines a sputum type of the patient who has undergone tracheostomy using a deep learning model based on a pattern difference between the spectrogram images converted by the image conversion unit.
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Ku, Cheol Ryong
Oh, Ju Hun
Kang, Chan Woo
Wang, Eun Kyung
Hong, Zhenyu
Lee, Yong Ho
Abrégé
The present invention relates to a pharmaceutical composition for preventing or treating liver disease comprising STC-1 or a derivative thereof as an active ingredient. The STC-1 protein according to the present invention reduces the expression of liver fibrosis markers ALT and Lect2 and reduces the area of fibrotic tissue, in animal models of liver fibrosis, indicating that it has excellent effects on the prevention and treatment of liver fibrosis and, furthermore, cirrhosis.
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61P 1/16 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif des troubles de la vésicule biliaire ou du foie, p. ex. protecteurs hépatiques, cholagogues, cholélitholytiques
32.
MICROBIOME-BASED COMPOSITION FOR PREVENTING AND TREATING MULTIDRUG-RESISTANT BACTERIAL INFECTIONS
INDUSTRY ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Yoon, Sang Sun
Choi, Jun Yong
Yoon, Mi Young
Jeong, Uk Jin
Abrégé
The present invention provides an antibacterial composition including two or more strains selected from the group consisting of Anaerostipes hadrus, Collinsella aerofaciens, Blautia wexlerae and Bifidobacterium longum strains that inhibit the activity of antibiotic-resistant bacteria.
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Park, Chang Ook
Kim, Yu Ri
Kim, Su Min
Kim, Hye Li
Zhang, Kelun
Kim, Hyun Soo
Abrégé
The present invention relates to a composition for prevention or treatment of inflammatory or autoimmune skin diseases. The composition of the present invention may be useful as a fundamental therapeutic composition that is able to efficiently ameliorate skin tissue damage caused by inflammation while having a minimized impact on systemic immune activity by specifically inhibiting the activity of skin-specific T cells. In addition, the composition of the present invention may be efficiently delivered to the stratum corneum of the skin, so that it is able to exert a lesion-specific and intensive immune control effect as a composition for topical application to the skin. Moreover, it shows little toxicity to normal skin tissue, and thus is suitable even for long-term administration for the treatment of atopic dermatitis, a chronic disease. The present invention also provides, based on the newly identified correlation between skin-specific T cells and PIK3CD protein, a screening method capable of quickly and highly reliably identifying promising therapeutic candidates that are able to alleviate various autoimmune and inflammatory damages occurring in skin tissue.
A61P 17/00 - Médicaments pour le traitement des troubles dermatologiques
A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
34.
NUCLEIC ACID CONSTRUCT ENABLING EXPRESSION AND INHIBITION OF GENE SIMULTANEOUSLY
INDUSTRY-ACADEMIC COOPERATION FOUNDATION (République de Corée)
EWHA UNIVERSITY - INDUSTRY (République de Corée)
Inventeur(s)
Lee, Kyuri
Lee, Hyuk Jin
Abrégé
The present invention relates to a nucleic acid construct that can express and inhibit a gene simultaneously. The nucleic acid construct that can express and inhibit a gene simultaneously, according to the present invention, comprises both mRNA and siRNA in a single construct, and thus, mRNA and siRNA are introduced simultaneously into the same cell. Accordingly, a protein to be expressed may be expressed normally while expression of a particular gene may be specifically inhibited. The mRNA-siRNA nucleic acid construct activates an immune system by expressing a target protein in an antigen-presenting cell, and at the same time, overcomes interference of immune escape by blocking the activity of an immune checkpoint protein, and thus is expected to be remarkably useful in the fields of immunotherapy, especially in the field of cancer immunotherapy.
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
CELLARTGEN INC. (République de Corée)
Inventeur(s)
Cho, Seung Woo
Lee, Mi Jeong
Song, Yong Seok
Hwang, Yong Soon
Abrégé
The present invention relates to nanoparticles comprising a decellularized spleen extracellular matrix and use thereof and, in particular, to: nanoparticles having a uniform size, which are obtained by producing hydrogel from a decellularized spleen extracellular matrix, and then freeze-milling the hydrogel; a method for producing same; use thereof; and the like. The nanoparticles comprising a decellularized spleen extracellular matrix, according to the present invention, have many excellent advantages such as an immunity-enhancing effect, biocompatibility, safety, biodegradability, and usability, and thus can be used as a novel adjuvant for enhancing vaccine immunity.
A61K 39/39 - Préparations médicinales contenant des antigènes ou des anticorps caractérisées par les additifs immunostimulants, p. ex. par les adjuvants chimiques
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
36.
LACTOBACILLUS STRAINS, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME FOR PREVENTING OR TREATING INFLAMMATORY DISEASES
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Yoon, Mi Young
Abrégé
The present invention provides a pharmaceutical composition, an antibacterial composition, a probiotic composition, and a food additive composition, which are for treating or preventing inflammatory diseases, and contain, as an active ingredient, any one from among a Lactobacillus animalis strain and a Limosilactobacillus reuteri strain, which have an ability to adjust uric acid concentration, mixed strains (accession number: KCTC 15190BP) of the Lactobacillus animalis and Limosilactobacillus reuteri strains, a culture medium of the Lactobacillus animalis strain, a culture medium of the Limosilactobacillus reuteri strain, and a culture medium of the mixed strains (accession number: KCTC 15190BP).
Industry-academic Cooperation Foundation, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Cho, Hyung Hee
Lee, Nam Kyu
Lim, Joon Soo
Chang, In Joong
Bae, Hyung Mo
Nam, Ju Yeong
Abrégé
A multiple and broadband stealth structure comprises a radar absorption unit that absorbs broadband microwave, a low-frequency transmission filter unit that is stacked on an upper portion of the radar absorption unit, and an infrared radiation unit that is combined with the low-frequency transmission filter unit to selectively emit infrared ray, thereby selectively controlling the infrared emissivity of the surface to emit infrared radiation only through an atmospheric absorption window with a low infrared transmittance and to avoid the infrared detection system.
F41H 3/00 - Camouflage, c.-à-d. moyens ou procédés de dissimulation ou de simulation
B64D 7/00 - Agencement à bord aéronefs des équipements militaires, p. ex. des armes, des accessoires d'armement ou des blindages de protectionAdaptations des installations d'armement aux aéronefs
38.
HYDROGEL INCLUDING PHENOL DERIVATIVE-MODIFIED CELLULOSE AND USE THEREOF
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Cho, Seung Woo
Choi, Yi Sun
Jeon, Ji Hoon
Abrégé
A hydrogel including phenol derivative-modified cellulose, a use thereof, and a preparation method therefor are described. Physical properties of the hydrogel can be modulated by adjusting concentrations of and oxidation conditions for the phenol derivative-modified cellulose. In addition, the hydrogel of the present invention can find applications in various fields due to its properties, such as hemostasis, blood coagulation acceleration, tissue adhesion, cell culture, cell transplantation, drug delivery, etc.
SAMSUNG ELECTRONICS CO., LTD. (République de Corée)
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Lee, Ho Taik
Kim, Woochul
Kim, Jiyong
Kwon, Bok Soon
Kim, Sang Kyu
Kim, Sungho
Park, Gimin
Woo, Seungjai
Lee, So Young
Rhee, Hong Soon
Abrégé
A heat flux sensor according to an embodiment of the present disclosure includes: a thermogalvanic cell; a first electrode and a second electrode which are respectively disposed on a first surface and a second surface of the thermogalvanic cell; and a processor configured to estimate heat flux by measuring a voltage, generated by a temperature difference between the first surface and the second surface, by using the first electrode and the second electrode, wherein core body temperature may be estimated based on the heat flux, estimated by the heat flux sensor, and a skin surface temperature of an object.
G01K 13/20 - Thermomètres médicaux par contact pour les humains ou les animaux
G01K 7/02 - Mesure de la température basée sur l'utilisation d'éléments électriques ou magnétiques directement sensibles à la chaleur utilisant des éléments thermo-électriques, p. ex. des thermocouples
Industry-Academic Cooperation Foundation, Yonsei University (République de Corée)
Inventeur(s)
Lee, Yeong Hee
Kang, Ri Ra
Ryu, Kyoung Han
Lee, Byung Hong
Lee, Sang Il
Yun, In Sik
Park, Jang Ung
Abrégé
Disclosed are a transparent electrode for a solar cell and a method of manufacturing the same. The transparent electrode for a solar cell has a low Young's modulus, excellent elasticity, self-healing properties, an average visible-light transmittance sufficient to implement bifacial properties, and excellent power conversion efficiency (PCE). In addition, the method of manufacturing the transparent electrode for a solar cell does not require an additional deposition process, so the electrode-manufacturing time can be reduced, and the electrode-manufacturing process can be performed separately from other solar-cell-manufacturing processes, which is advantageous for mass production and large-area application.
H01G 9/00 - Condensateurs électrolytiques, redresseurs électrolytiques, détecteurs électrolytiques, dispositifs de commutation électrolytiques, dispositifs électrolytiques photosensibles ou sensibles à la températureProcédés pour leur fabrication
H01G 9/042 - Électrodes caractérisées par le matériau
41.
COLOR CHANGE SENSOR USING HOLLOW SILICA AND ION-PAIRING DYE CAPABLE OF DETECTING TRACE AMOUNTS OF ACETONE GAS
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Lee, Wooyoung
Kim, Jung Hyun
Shin, Kyusik
Park, Jae Jung
Kim, Youngno
Kim, Gaeun
Lee, Jihyun
Abrégé
The present disclosure relates to a color change dye prepared by impregnating hollow silica with a dye having a cationic dye and an anionic dye prepared using ion pairing, a sensor for detecting gas containing the above dye and a method for preparing the same, and more specifically to, a sensor that increases sensitivity and stability by increasing the area where the dye touches the gas and protecting the dye itself, since cationic dyes and anionic dyes are ion-paired to increase humidity resistance and react only with a trace amount of acetone. and the ion-paired dyes are then impregnated into hollow silica, and a method for preparing the same.
G01N 21/29 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en utilisant la détection visuelle
G01N 33/00 - Recherche ou analyse des matériaux par des méthodes spécifiques non couvertes par les groupes
42.
MEMORY DEVICE USING A PLURALITY OF SUPPLY VOLTAGES AND OPERATING METHOD THEREOF
Samsung Electronics Co., Ltd. (République de Corée)
Industry-Academic Cooperation Foundation, Yonsei University (République de Corée)
Inventeur(s)
Choi, Taemin
Kim, Taehyun
Jung, Seongook
Abrégé
A memory device accessed by circuits operating based on a first supply voltage. The memory device includes a cell array electrically connected to a plurality of word lines and a plurality of bit lines; a row driver configured to select one word line of the plurality of word lines based on a row address; a precharge circuit configured to precharge the plurality of bit lines based on the first supply voltage; a column driver configured to select at least one bit line of the plurality of bit lines based on a column address; and a read circuit configured to read data stored in the cell array through the at least one bit line. The cell array, the row driver, the column driver, and the read circuit operate based on a second supply voltage, which is higher than the first supply voltage.
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Lee, Won Woo
Chu, Min Kyung
Abrégé
The present invention relates to a facial image-based method for providing information about a headache, and an apparatus using same, wherein the facial image-based method, which is implemented by a processor, comprises the steps of: receiving facial image data from a user device; determining landmark-identified facial image data with the facial image data as input, by using a landmark identification model configured to output the landmark-identified facial image data with the facial image data as input; and determining user headache data with the landmark-identified facial image data as input, by using a headache determination model configured to output the user headache data with the landmark-identified facial image data as input.
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
G16H 50/50 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour la simulation ou la modélisation des troubles médicaux
G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p. ex. l’édition
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Cheong, Jae-Ho
Kim, Jae-Woo
Yoon, Bo Kyung
Abrégé
A composition and method according to the present invention may be very effectively used to diagnose malignant gastric cancer and predict the prognosis of gastric cancer.
C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer
45.
ANTENNA AND WEARABLE ELECTRONIC DEVICE INCLUDING SAME ANTENNA
Samsung Electronics Co., Ltd. (République de Corée)
INDUSTRY-ACADEMIC COOPERATION FOUNDATION YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Nam, Yongsik
Woo, Taehyun
Yoon, Youngjoong
Kim, Donghyun
Park, Chanyeong
Do, Myeounghyeoun
Han, Taegyeong
Abrégé
A wearable electronic device is provided. The wearable electronic device includes a housing, a printed circuit board disposed inside the housing and including wireless communication circuitry and a ground part, and an antenna disposed inside the housing and electrically connected to the wireless communication circuitry, wherein the antenna includes a conductive pattern, a feeding member electrically connected to the wireless communication circuitry through a feeding point and configured to electrically connect a first point of the conductive pattern and a first point of the ground part, a short-circuit member configured to electrically connect a second point of the conductive pattern and a second point of the ground part, and a capacitive loading member disposed between the feeding member and the short-circuit member having a first part operatively coupled to a third point of the conductive pattern and a second part electrically connected to a third point of the ground part.
THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY- ACADEMIC COOPERATION FOUNDATION (République de Corée)
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Joo, Young Hoon
Kim, Hyun Bum
Kim, Jong Baeg
Jung, Yo Han
Koh, Dae Yeon
Kim, Min Hyeong
Han, Hyun Jun
Abrégé
Proposed are a phlegm suction alarm issuing apparatus and a method for a tracheostomy patient which monitor and analyze a respiratory sound of the tracheostomy patient in real time, then check congestion of phlegm, and issue a phlegm suction alarm.
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 5/08 - Dispositifs de mesure pour examiner les organes respiratoires
47.
VEST-TYPE SPEAKER, SPEAKER CONTROL DEVICE, CONTROL METHOD, AND SYSTEM FOR REMOVING BRONCHIAL SPUTUM OF PATIENT WITH LUNG DISEASE BY USING VIBRATION AND SOUND WAVE
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Park, Incheol
Abrégé
This vest-type speaker device comprises: a communication unit; at least one speaker positioned corresponding to the user's lung; a memory; and a processor for controlling the operation of a battery, wherein the processor is configured to receive a control signal based on user condition information from an external electronic device through the communication unit, and output sound waves and vibrations through the at least one speaker on the basis of the control signal.
A61H 23/02 - Massage par percussion ou vibration, p. ex. en utilisant une vibration ultrasoniqueMassage par succion-vibrationMassage avec des membranes mobiles à entraînement électrique ou magnétique
A61M 16/00 - Dispositifs pour agir sur le système respiratoire des patients par un traitement au gaz, p. ex. ventilateursTubes trachéaux
H04R 1/32 - Dispositions pour obtenir la fréquence désirée ou les caractéristiques directionnelles pour obtenir la caractéristique directionnelle désirée uniquement
A61B 6/00 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations
A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiquesMesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p. ex. formation d'images par résonance magnétique
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Lim, Joonryul
Chun, Yong Min
Abrégé
The present invention relates to a forearm fixing apparatus for a therapeutic robot for restoring and maintaining the range of motion of joints of an upper extremity, comprising: a fixing unit in which the forearm of a user is fixed to one surface thereof; a handle that is provided to be inclined on one surface of the fixing unit and gripped by a hand of the user; a plurality of frames provided at intervals on the other surface of the fixing unit; and a connector that is detachably coupled to any one of the plurality of frames and provided on a robot arm.
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Cheong, Jae-Ho
Kim, Jae-Woo
Fang, Sungsoon
Yoon, Bo Kyung
Kim, Hyeonhui
Abrégé
The present invention relates to a method for prevention, alleviation, or treatment of cancer patients, especially epithelial mesenchymal transition (EMP)-subtype cancer patients. If PHGDH, SHMT and MTHFD2 inhibitors are co-administered to patients with cancer in which the expression level of a glutaminase (GLS) gene or a protein encoded thereby has increased, 1C metabolism is more effectively inhibited such that there is a synergistic effect on the inhibition of cancer cell proliferation in patients with refractory cancer that is difficult to treat because of recurrence, metastasis, and anticancer drug resistance, thereby enabling cancer to be very effectively treated. In addition, the expression level of the GLS gene or protein encoded thereby is measured so that information related to customized treatment methods from initial stages is provided to each patient and the success of treatment can be increased.
C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
50.
PHARMACEUTICAL COMPOSITION FOR TREATING INFLAMMATORY DISEASES COMPRISING GERMANIUM TELLURIDE NANOSHEETS COATED WITH POLYVINYLPYRROLIDONE
Industry-Academic Cooperation Foundation (République de Corée)
Inventeur(s)
Yoo, Kyung-Hwa
Song, Jun Ho
Park, Yong-Beom
Lee, Sun-Mi
Min, Chin Hee
Yoon, Taejun
Abrégé
The present invention relates to a composition for treating inflammatory diseases comprising germanium telluride nanosheets coated with polyvinylpyrrolidone, and the nanosheets have excellent anti-inflammatory and thus are excellent in treating inflammatory bowel disease and psoriasis.
A61K 33/00 - Préparations médicinales contenant des ingrédients actifs inorganiques
A61K 33/04 - Soufre, sélénium ou tellureLeurs composés
A61P 1/04 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif des ulcères, des gastrites ou des œsophagites par reflux, p. ex. antiacides, antisécrétoires, protecteurs de la muqueuse
A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]
A61P 37/00 - Médicaments pour le traitement des troubles immunologiques ou allergiques
51.
PYRIMIDINE DERIVATIVE HAVING PROTEIN KINASE INHIBITORY ACTIVITY, AND THERAPEUTIC PHARMACEUTICAL COMPOSITION COMPRISING SAME
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Sim, Tae Bo
Cho, Byoung Chul
Cho, Han Na
Sengupta, Sandip
Malla Reddy, Gannarapu
Kim, Young Hoon
Abrégé
The present invention relates to a pharmaceutical composition for preventing and treating a cancer disease, including lung cancer, caused by abnormal cell growth containing a novel trisubstituted pyrimidine derivative with inhibitory activity against protein kinases, including EGFR, and a pharmaceutically acceptable salt thereof as active ingredients. The novel compound of the present invention has strong inhibitory activity against protein kinases. Particularly, the novel compound of the present invention has potent inhibitory effects against various drug-resistant EGFR mutants (including exon 19 deletion-T790M-C797S-EGFR, L858R-T790M-C797S-EGFR, exon 19 deletion-T790M-EGFR, and L858R-T790M-EGFR) and is useful as a prophylactic and therapeutic agent for cancer diseases caused by these EGFR mutants.
C07D 401/12 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 9/48 - Préparations en capsules, p. ex. de gélatine, de chocolat
A61K 31/506 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime non condensées et contenant d'autres hétérocycles
A61K 31/53 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec trois azote comme seuls hétéro-atomes d'un cycle, p. ex. chlorazanil, mélamine
A61K 31/5377 - 1,4-Oxazines, p. ex. morpholine non condensées et contenant d'autres hétérocycles, p. ex. timolol
A61K 31/541 - Thiazines non condensées contenant d'autres hétérocycles
A61K 31/55 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à sept chaînons, p. ex. azélastine, pentylènetétrazole
A61K 31/551 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à sept chaînons, p. ex. azélastine, pentylènetétrazole ayant deux atomes d'azote comme hétéro-atomes d'un cycle, p. ex. clozapine, dilazèpe
A61K 31/675 - Composés du phosphore ayant l'azote comme hétéro-atome d'un cycle, p. ex. phosphate de pyridoxal
A61K 47/26 - Hydrates de carbone, p. ex. polyols ou sucres alcoolisés, sucres aminés, acides nucléiques, mono-, di- ou oligosaccharidesLeurs dérivés, p. ex. polysorbates, esters d’acide gras de sorbitan ou glycyrrhizine
C07D 401/14 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant au moins trois hétérocycles
C07D 405/14 - Composés hétérocycliques contenant à la fois un ou plusieurs hétérocycles comportant des atomes d'oxygène comme uniques hétéro-atomes du cycle et un ou plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle contenant au moins trois hétérocycles
C07D 417/14 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre et d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant au moins trois hétérocycles
C07F 9/6558 - Composés hétérocycliques, p. ex. contenant du phosphore comme hétéro-atome du cycle contenant au moins deux hétérocycles différents ou différemment substitués ni condensés entre eux ni condensés avec un carbocycle commun ou un système carbocyclique commun
52.
Gold-Doped Nickel Nanocluster, Preparation Method Therefor, and Use Thereof
Industry-Academic Cooperation Foundation, Yonsei University (République de Corée)
Inventeur(s)
Lee, Dongil
Choi, Woojun
Jo, Yongsung
Abrégé
Provided is a gold-doped nickel nanocluster having a specific number of gold atoms, nickel atoms, and organothiol-based ligands. The gold atoms, the nickel atoms, and the organothiol-based ligands are bonded in a specific structure, a method for manufacturing the same, an electrode for converting carbon dioxide including the same, and a method for converting carbon dioxide using the same.
C25B 11/095 - Électrodes comportant des électro-catalyseurs sur un substrat ou un support caractérisées par le matériau électro-catalytique formé d’au moins un élément catalytique et d’au moins un composé catalytiqueÉlectrodes comportant des électro-catalyseurs sur un substrat ou un support caractérisées par le matériau électro-catalytique formé de plusieurs éléments catalytiques ou composés catalytiques au moins un des composés est de type organique
AGENCY FOR DEFENSE DEVELOPMENT (République de Corée)
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Kim, Jeong-Woo
Cho, Hyung-Hee
Lee, Joo-Hyoung
Bang, Min-Ho
Kim, Jeong-Ju
Choi, Seung-Yeong
Kim, Tae-Hyun
Park, Hee-Seung
Abrégé
The present invention relates to a gas turbine blade having a shelf squealer tip, the gas turbine blade including an airfoil-shaped blade housing, and a squealer tip extending from an edge portion of a tip surface that is an end surface of the blade housing, in which the squealer tip is formed only on a part of the edge portion of the tip surface. According to the present invention, it is possible to maximize film-cooling performance on the tip surface and additionally reduce an aerodynamic loss by suppressing high-temperature main flow reattachment and swirl flow generation on the tip surface.
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Lee, Jae Young
Ham, Sang Woo
Bae, Hee Sook
Cho, Gyu Bon
Jang, Jae Hyung
Kim, Yun Ha
Lee, Dong Soo
Abrégé
The present application relates to a vector for delivering an active agent to the nervous system. In one embodiment of the present application, a vector for delivering an active agent in which one or more TTR ligands are conjugated to the surface of an adeno-associated virus is provided.
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
A61K 47/69 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament le conjugué étant caractérisé par sa forme physique ou sa forme galénique, p. ex. émulsion, particule, complexe d’inclusion, stent ou kit
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Ryu, Ji-Hwan
Chung, Youn Wook
Jeong, Daeun
Abrégé
The present invention is applicable as a biomarker for allergic rhinitis, enabling easy distinction from normal people by detecting has-let-7a-5p, which is a micro RNA present in exosomes, by using nasal washing fluid that can be non-invasively obtained. Furthermore, the present invention can also be used as a therapeutic agent for allergic rhinitis due to use of the mechanism of suppressing mucus hypersecretion when let-7a-5p is overexpressed.
C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique
56.
APPARATUS AND METHOD FOR CONTROLLING SIGNALS BY USING METASURFACE IN WIRELESS COMMUNICATION SYSTEM
INDUSTRY -ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Chung, Jaehoon
Min, Byung-Wook
Kim, Sung Eun
Abrégé
The present disclosure is to control signals by using a metasurface in a wireless communication system. An operating method of a communication apparatus may comprise the steps of: generating at least one codeword by encoding information bits; generating modulation symbols on the basis of the at least one codeword; mapping the modulation symbols to at least one layer; and transmitting signals including the modulation signals mapped to the at least one layer. The signals may include a first signal transmitted to a first apparatus located in a first direction and a second signal transmitted to a second apparatus located in a second direction, and the first signal and the second signal may be transmitted in the first direction and the second direction by outputting the first signal and the second signal toward a plurality of unit cells and independently applying phase change patterns, which are generated by the plurality of unit cells, to the first signal and the second signal, respectively.
H01Q 3/30 - Dispositifs pour changer ou faire varier l'orientation ou la forme du diagramme de directivité des ondes rayonnées par une antenne ou un système d'antenne faisant varier la phase relative ou l’amplitude relative et l’énergie d’excitation entre plusieurs éléments rayonnants actifsDispositifs pour changer ou faire varier l'orientation ou la forme du diagramme de directivité des ondes rayonnées par une antenne ou un système d'antenne faisant varier la distribution de l’énergie à travers une ouverture rayonnante faisant varier la phase
H01Q 21/24 - Combinaisons d'unités d'antennes polarisées dans des directions différentes pour émettre ou recevoir des ondes polarisées circulairement ou elliptiquement ou des ondes polarisées linéairement dans n'importe quelle direction
57.
SERVER AND METHOD FOR PREDICTING INCIDENCE OF MOYAMOYA DISEASE THROUGH LEARNING OF FUNDUS IMAGE
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Park, Yu Rang
Hong, Jae Seong
Shim, Kyu Won
Yoon, Sang Chul
Abrégé
Disclosed are a server for predicting incidence of a moyamoya disease through learning of a fundus image, and a method thereof. The server according to an embodiment of the present disclosure labels input fundus images as a moyamoya disease patient with the moyamoya disease and a normal patient without the moyamoya disease, learns the incidence prediction model by recognizing fundus images labeled as the moyamoya disease patient and fundus images labeled as the normal patient into the incidence prediction model, and predicts the incidence probability of the moyamoya disease by inputting the new fundus image into the learned incidence prediction model when a new fundus image is input.
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p. ex. pour des dossiers électroniques de patients
G16H 30/20 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le maniement d’images médicales, p. ex. DICOM, HL7 ou PACS
G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p. ex. l’édition
G16H 50/70 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour extraire des données médicales, p. ex. pour analyser les cas antérieurs d’autres patients
58.
DEVICE AND METHOD FOR DETERMINING PROSTHETIC OPTIONS FOR IMPLANT BY USING MACHINE LEARNING MODEL
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Kim, Jong Eun
Park, Ji Hyun
Abrégé
This method for determining prosthetic options for an implant comprises the steps of: obtaining an implant image comprising an implant fixture region; identifying an implant manufacturer on the basis of the implant image by using a first machine learning model; estimating detailed specifications of an implant fixture on the basis of the implant fixture region by using a second machine learning model, and identifying an implant model corresponding to the detailed specifications; and determining a prosthetic option corresponding to the diameter of the upper portion of the implant fixture with reference to a database.
G06T 1/00 - Traitement de données d'image, d'application générale
G06T 17/00 - Modélisation tridimensionnelle [3D] pour infographie
G16H 50/50 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour la simulation ou la modélisation des troubles médicaux
G16H 30/00 - TIC spécialement adaptées au maniement ou au traitement d’images médicales
A61C 8/00 - Moyens destinés à être fixés à l'os de la mâchoire pour consolider les dents naturelles ou pour y assujettir des prothèses dentairesImplants dentairesOutils pour l'implantation
Industry-Academic Cooperation Foundation, Yonsei University (République de Corée)
Inventeur(s)
Kim, Taewoong
Ahn, Jong Hyun
Park, Boik
Kim, Beom Jin
Shin, Heechang
Abrégé
A display device includes a display panel, a first auxetic structure including a first pattern that defines a plurality of first openings, overlapping the display panel, and having a negative Poisson's ratio, a second auxetic structure including a second pattern that defines a plurality of second openings, overlapping the first auxetic structure, and having a negative Poisson's ratio, and a support layer disposed below the display panel and supporting the display panel.
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Cho, Si Hyun
Im, Wooseok
Lee, Jae Hoon
Lee, Inha
Kim, Sehee
Abrégé
The present invention relates to a composition for diagnosing endometriosis, the composition comprising an agent for measuring the level of miRNA as an active ingredient. The present invention was developed in an effort to overcome the conventional diagnostic difficulties and treatment limitations associated with endometriosis. As a result, during the search for new diagnostic targets in endometrial cells isolated from healthy controls and patients with endometriosis, a difference in the expression of miRNA within exosomes was identified. It was found that the expression of miRNA within exosomes isolated from patients with endometriosis significantly increased or decreased compared to healthy controls, leading to the completion of the present invention. The composition can be advantageously utilized as a diagnostic and therapeutic agent for endometriosis.
C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique
A61K 31/7105 - Acides ribonucléiques naturels, c.-à-d. contenant uniquement des riboses liés à l'adénine, la guanine, la cytosine ou l'uracile et ayant des liaisons 3'-5' phosphodiester
A61P 15/02 - Médicaments pour le traitement des troubles génitaux ou sexuelsContraceptifs pour les pathologies du vagin
61.
DENTAL COMPOSITE RESIN COMPOSITION HAVING ANTIBACTERIAL EFFECTS, AND METHOD FOR PREPARING SAME
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Lee, Jinu
Yoon, Sei Mee
Oh, Sang Ho
Kim, Ji Young
Abrégé
The present invention relates to a composition for preventing, ameliorating and treating skin damage, comprising, as an active ingredient, (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate or a pharmaceutically acceptable salt thereof. When the composition of the present invention is administered, collagen synthesis in the dermal layer of the skin is promoted and thus it is possible to more effectively treat and ameliorate skin damage caused by particulate matter.
A61K 8/49 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant des composés hétérocycliques
A61Q 19/00 - Préparations pour les soins de la peau
A61Q 19/08 - Préparations contre le vieillissement
A23L 33/10 - Modification de la qualité nutritive des alimentsProduits diététiquesLeur préparation ou leur traitement en utilisant des additifs
A61K 31/366 - Lactones ayant des cycles à six chaînons, p. ex. delta-lactones
A61P 17/00 - Médicaments pour le traitement des troubles dermatologiques
63.
COMPRESSION AND RECOVERY-BASED OTFS SYSTEM FOR IMPROVING TRANSMISSION EFFICIENCY, AND TRANSMISSION AND RECEPTION METHOD THEREOF
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Choi, Soo Yong
An, Cheol Kyun
Abrégé
The disclosed embodiment provides an OTFS system capable of improving transmission efficiency while maintaining high compatibility with respect to an OFDM system and performance gains of channel estimation and compensation of an existing OTFS system, and a transmission and reception method thereof, the OTFS system comprising: a sample compression precoder that receives an application of a QAM symbol of a size L x M (where L and N are natural numbers), and compresses and transforms the QAM symbol into a delay-Doppler (hereinafter, DD) symbol having a size M x N (which are natural numbers in which M < L) in a DD domain; a two-dimensional domain transform module that transforms the DD symbol into a time frequency (hereinafter, TF) symbol having a size M x N in a TF domain; and a modulator that transmits a transmission signal in a time domain, which is acquired by modulating the TF symbol.
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Yong, Dong Eun
Choi, Jun Yong
Han, Chang Ku
Abrégé
The present invention relates to a dual capsule for fecal microbiota transplantation and a manufacturing method therefor. When being orally administered, the dual capsule for fecal microbiota transplantation of the present invention makes it possible to suppress multi-drug resistant bacteria within the body and can be utilized for the prevention or treatment of infections of multi-drug resistant bacteria.
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
BICBIO INC. (République de Corée)
Inventeur(s)
Jang, Sung Ill
Lee, Dong Ki
Cho, Jae Hee
Nahm, Ji Hae
Lee, Namseok
Han, Eun-Joo
Jung, Seunghwan
Abrégé
Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related deaths worldwide, but lacks effective prognostic indicators. Methionyl-tRNA synthetase 1 (MARS1), which is an important enzyme in translation initiation for delivering Met to initiator tRNA, is associated with cancer development and progression. MARS1 expression was found to significantly increase in PDAC compared to normal pancreatic duct tissue. In addition, the high expression of MARS1 was found to be associated with poor prognosis in PDAC patients. This suggests that MARS1 is involved in pancreatic carcinogenesis and has potential as a novel prognostic indicator for PDAC.
C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer
66.
REPROGRAMMED SMOOTH MUSCLE CELLS AND METHODS RELATED THERETO
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Yoon, Young-Sup
Kim, Kyung Hee
Han, Ji Woong
Jung, Cholomi
Lee, Shin-Jeong
Abrégé
Provided herein are novel reprogrammed smooth muscle cells (rSMCs) and methods of making and using the cells for the treatment of ischemia. The rSMCs are produced by culturing a fibroblast with an all-trans-retinoic acid (ATRA) under conditions that produce the rSMC from the fibroblast, wherein the fibroblasts are genetically modified to overexpress myocardin. The rSMCs offer advantages over currently available regenerative vascular therapies by promoting vascular perfusion in a recipient subject. In particular, the rSMCs can increase neovascularization of both small and large vessels.
C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p. ex. lignées cellulairesTissusLeur culture ou conservationMilieux de culture à cet effet
C12N 5/071 - Cellules ou tissus de vertébrés, p. ex. cellules humaines ou tissus humains
67.
PRECISE MEASUREMENT APPARATUS AND METHOD OF SKIN MOISTURE
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Oh, Seung Jae
Maeng, In Hee
Abrégé
The present invention relates to a precise measurement apparatus and method of skin moisture and, more specifically, to a precise measurement apparatus and method of skin moisture that is not affected by pressure applied to the apparatus. The precise measurement apparatus of skin moisture, according to an aspect of the present invention, may comprise: a main body that is open toward a to-be-measured object and has a hollow portion; a contact portion that is slidably movably mounted on the main body and has a window for being in contact with the to-be-measured object; and a connection portion that connects the main body and the contact portion and includes an elastic member provided so as to be compressed, when the contact portion slides into the main body.
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 5/0507 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiquesMesure utilisant des micro-ondes ou des ondes radio utilisant des micro-ondes ou des ondes térahertz
Industry-Academic Cooperation Foundation, Yonsei University (République de Corée)
Inventeur(s)
Hwang, Seong-Ju
Lee, Jihyeong
Abrégé
Provided are a porous nanosheet and a method for manufacturing the same, and a porous nanosheet which may include holes on the surface while maintaining a two-dimensional nanosheet form and may significantly improve catalyst efficiency and economic feasibility while minimizing platinum usage by introducing a platinum single atom to the holes, and a method for manufacturing the same are provided.
C25B 11/091 - Électrodes comportant des électro-catalyseurs sur un substrat ou un support caractérisées par le matériau électro-catalytique formé d’au moins un élément catalytique et d’au moins un composé catalytiqueÉlectrodes comportant des électro-catalyseurs sur un substrat ou un support caractérisées par le matériau électro-catalytique formé de plusieurs éléments catalytiques ou composés catalytiques
C25B 1/04 - Hydrogène ou oxygène par électrolyse de l'eau
Samsung Electronics Co., Ltd. (République de Corée)
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Yong, Jaecheon
Ko, Daehong
Abrégé
A semiconductor memory device includes a source layer, a semiconductor layer including a semiconductor protrusion structure, and a drain layer arranged in a first horizontal direction on a substrate, a cell capacitor extending in the first horizontal direction on the substrate and including a lower electrode layer, a capacitor dielectric film, and an upper electrode layer connected to the drain layer, a bit line extending in a vertical direction on the substrate and connected to the source layer, and a gate structure covering the semiconductor protrusion structure and including a gate dielectric film on the semiconductor protrusion structure and a gate electrode film on the gate dielectric film. A value of a first thickness of an end portion of the semiconductor protrusion structure facing the drain layer is greater than a value of a second thickness of another end portion of the semiconductor protrusion structure facing the source layer.
H10B 12/00 - Mémoires dynamiques à accès aléatoire [DRAM]
70.
ALL-IN-ONE CELL CONTROL TECHNIQUE BASED ON PHOTOSENSITIVE POLYMER FILM CAPABLE OF ENTIRE PROCESS OF CELL CULTURE, GROWTH PROMOTION, AND CELL SHEET SEPARATION AND DELIVERY
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Park, Jong-Chul
Koo, Min-Ah
Lee, Mi Hee
Hong, Seung Hee
Go, Eunjeong
Abrégé
The present invention relates to a method for manufacturing a photosensitive polymer film comprising a polymer material and a photosensitizer, and to a method for promoting cell proliferation and a method for separating cells, which comprise a step of irradiating the photosensitive polymer film with light. According to the photosensitive polymer film according to the present invention, all processes of cell culture, growth promotion, and cell sheet separation and delivery thereof are performed on a single photosensitive polymer film at once by controlling only the density and irradiation time of light energy, resulting in low costs, a simple procedure, and less time.
C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p. ex. lignées cellulairesTissusLeur culture ou conservationMilieux de culture à cet effet
C12N 5/077 - Cellules mésenchymateuses, p. ex. cellules osseuses, cellules de cartilage, cellules stromales médulaires, cellules adipeuses ou cellules musculaires
71.
AUDIO SIGNAL PROCESSING APPARATUS AND METHOD FOR DEEP NEURAL NETWORK-BASED AUDIO ENCODER AND DECODER
ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE (République de Corée)
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Sung, Jong Mo
Beack, Seung Kwon
Park, Young Cheol
Byun, Joon
Shin, Seung Min
Abrégé
An audio signal processing method, which is executed by a processor electronically communicating with a deep neural network within a computing system, may comprise: acquiring, by the processor, an input signal before encoding and an output signal after quantization and decoding; calculating, by the processor, a perceptual global loss for a frame corresponding to the input and the output signals; acquiring, by the processor, a plurality of subframes corresponding to the input and output signals by applying a windowing function to the frame of the input and output signals; calculating, by the processor, perceptual local losses for the plurality of subframes corresponding to the input and output signals; and acquiring, by the processor, multi-time scale perceptual loss based on the perceptual global and local losses.
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Kim, Sung Jun
Yoon, Young No
Abrégé
Provided are a method of providing information on a rib fracture, and a device for providing information on a rib fracture by using same. The method of providing information on a rib fracture, implemented by a processor, comprises the steps of: receiving a chest medical image of a subject; extracting the chest medical image patch by patch; determining, by using a convolutional neural network model pretrained to determine rib fracture probability by using a patch as an input, rib fracture probability by using the patch as an input; generating a class activation map (CAM) patch by patch; and reconstructing the entire class activation map generated patch by patch, to correspond to the entire chest medical image.
A61B 6/00 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations
A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiquesMesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p. ex. formation d'images par résonance magnétique
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p. ex. l’édition
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Park, Hyun Woo
Huh, Hyunbin
Abrégé
The present disclosure relates to a method for discovering factors determining adhesion dependence of cells and a method for preventing or treating cancer, specifically metastatic cancer by regulating the expression of the factors. The present disclosure suggests a completely new inhibitory target for cancer metastasis, which allows remarkable blocking of the production of circulating tumor cells from primary cancer tissues and, ultimately, provision of an effective anticancer composition capable of significantly reducing the mortality rate of cancer.
C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
74.
MULTI-COMPONENT POLYIMIDE COMPOSITION CAPABLE OF SELF-HEALING AND FILM AND METHOD FOR MANUFACTURING SAME
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (République de Corée)
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Jung, Yong Chae
Kim, Young Nam
Han, Haksoo
Lee, Ju Heon
Abrégé
The present specification provides a polyimide resin composition which exhibits excellent transparency and mechanical properties while being capable of repeated self-healing, by comprising a multi-component polyimide combination, and a film comprising same. The film according to the present disclosure exhibits self-healing properties that can self-heal damage, such as cracks or shape deformation, that occurs at room temperature, wherein the self-healing is repeated. Thus, the lifespan of the film can be extended and reuse thereof is possible. The present disclosure can be used as an adhesive or a coating agent in electrical and electronic materials, and the like, and for example, can be effectively used as a cover window for covering the surface of a mobile, a display, or the like.
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Kim, Hyun Seok
Kim, Ju-Hwa
Lee, Hwanho
Kim, Tae Il
Abrégé
The present invention relates to a pharmaceutical composition for inhibiting cancer metastasis and, preferably, to a pharmaceutical composition for inhibiting invasion or metastasis by invasive colon cancer. The composition of the present invention, in invasive colon cancer especially that with a poor prognosis, is non-toxic to cancer cells and has the effect of only inhibiting invasion, and thus can minimize human toxicity, which can be an inevitable side effect of anticancer agents, and can effectively prevent only invasion or metastasis, which is fatal with respect to prognosis, and thus can extend the survival of cancer patients.
KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION (République de Corée)
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Baek, Wooyeol
Chung, Jae-Ho
Yoon, Eul-Sik
Jo, Han Saem
Park, Yongkyu
Shim, Kyu-Sik
Kim, Dohyun
Heo, Min
Abrégé
The present invention relates to a human implant for inducing body vessel regeneration and a method of treating lymphedema or ischemic disease using same. A structure according to the present invention provides appropriate physical strength and mechanical support, and thus not only prevents body vessels, such as lymph vessels or blood vessels, from being re-damaged during regeneration, but also promotes the flow of body fluids through capillary action by using a simple rod structure having concave and convex portions (e.g., H-shaped steel) or lumens (e.g., tubular shape), thereby structurally and functionally mimicking in-vivo body vessel tissues. In addition, the structure of the present invention decomposes at an appropriate point in time after the completion of body vessel regeneration after being implanted in a lesion, and thus can be useful as an efficient treatment for various pathological conditions caused by blocked lymphatic fluid flow or reduced blood flow.
A61L 27/18 - Matériaux macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone
A61L 27/58 - Matériaux au moins partiellement résorbables par le corps
77.
METHOD AND DEVICE FOR PERFORMING SELF-INTERFERENCE CANCELLATION
SAMSUNG ELECTRONICS CO., LTD. (République de Corée)
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Lee, Kwonjong
Kim, Yonghwi
Chae, Chanbyoung
Abrégé
The present disclosure relates to a 5G or 6G communication system for supporting a higher data transmission rate beyond a 4G communication system such as LTE. The present disclosure provides a method for performing self-interference cancellation by a base station. The method of the present disclosure may comprise the steps of: acquiring adjacent resource block (RB)-related information for estimation of a self-interference (SI) coefficient; generating information on a reference signal pattern for each RB on the basis of the adjacent RB-related information; transmitting, to the terminal, information on the reference signal pattern for each RB; generating a downlink (DL) reference signal on the basis of the information on the reference signal pattern for each RB, and transmitting the DL reference signal to the terminal; receiving an SI signal associated with the DL reference signal; estimating the SI coefficient on the basis of the DL reference signal and the SI signal associated with the DL reference signal; and performing cancellation of the SI signal from a received UL signal on the basis of the SI coefficient.
NON-INVASIVE BLOOD VISCOSITY MEASUREMENT METHOD AND SYSTEM BASED ON OXYGEN SATURATION AND BLOOD FLOW FOR PREDIABETES PREDICTION AND DEHYDRATION MEASUREMENT
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Lee, Joon Sang
Abrégé
The present invention relates to a non-invasive blood viscosity measurement method and system based on oxygen saturation and blood flow. The method and system for measuring blood viscosity in a non-invasive manner on the basis of oxygen saturation and blood flow is used to facilitate easy and rapid calculation of blood viscosity, thus enabling the immediate acquisition of blood viscosity data.
A61B 5/02 - Détection, mesure ou enregistrement en vue de l'évaluation du système cardio-vasculaire, p. ex. mesure du pouls, du rythme cardiaque, de la pression sanguine ou du débit sanguin
A61B 5/1455 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang en utilisant des capteurs optiques, p. ex. des oxymètres à photométrie spectrale
A61B 5/145 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Lee, Seung Ah
Kim, Tae Young
Lee, Kyung Won
Baek, Nak Kyu
Jung, Jae Woo
Abrégé
The disclosed embodiment provides an apparatus and method for measuring eye movement, that can accurately measure eye movement by determining the eye position at high speed and high resolution even with a low-cost camera by using a phase mask and rolling shutter method instead of a lens, and can perform early diagnosis of neurological diseases, etc. based on the measured eye movement.
Industry-Academic Cooperation Foundation, Yonsei University (République de Corée)
Inventeur(s)
Kim, Jiwon
Lee, Jiyeon
Ryu, Jaehyeok
Kim, Dongjun
Oh, Seoyeah
Park, Jihyeon
Kim, Geonho
Yoon, Seoyoung
Park, Hyunbin
Abrégé
Provided are perovskite quantum dots showing an independent photoreaction to light stimulation in different wavelength bands from each other, a method for preparing the perovskite quantum dots, and an anti-counterfeiting ink including the perovskite quantum dots.
C09K 11/77 - Substances luminescentes, p. ex. électroluminescentes, chimiluminescentes contenant des substances inorganiques luminescentes contenant des métaux des terres rares
C09K 11/61 - Substances luminescentes, p. ex. électroluminescentes, chimiluminescentes contenant des substances inorganiques luminescentes contenant du fluor, du chlore, du brome, de l'iode ou des halogènes non spécifiés
C09K 11/66 - Substances luminescentes, p. ex. électroluminescentes, chimiluminescentes contenant des substances inorganiques luminescentes contenant du germanium, de l'étain ou du plomb
81.
COMPOSITION FOR TREATMENT OF ANTICANCER DRUG RESISTANCE
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Cheong, Jae-Ho
Kim, Jae-Woo
Yoon, Bo Kyung
Abrégé
A composition according to the present invention, when used alone, is capable of inhibiting the growth of anticancer drug-resistant cancer by overcoming anticancer drug resistance or enhancing anticancer drug sensitivity, and when co-administered with an anticancer drug, may be used very effectively for the prevention, alleviation or treatment of various cancers, especially anticancer drug-resistant cancer.
A61K 31/4525 - Pipéridines non condensées, p. ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un cycle à cinq chaînons avec l'oxygène comme hétéro-atome du cycle
A61K 31/4545 - Pipéridines non condensées, p. ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un cycle à six chaînons avec l'azote comme hétéro-atome du cycle, p. ex. pipampérone, anabasine
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
Industry-Academic Cooperation Foundation, Yonsei University (République de Corée)
Inventeur(s)
Lee, Dong Woo
Jin, Hyeon Su
Lee, Ji Young
Lee, Jae Eun
Abrégé
The present invention relates to GPCR ligand collagen peptides produced through microbial fermentation, and in particular, to a method of preparing collagen peptides obtained by culturing a microorganism, peptides prepared by the method, and a composition including the peptide as an active ingredient; and a composition for improving intestinal function, relieving inflammation, and/or promoting wound healing, and a method of preparing the composition.
A61K 38/39 - Peptides du tissu connectif, p. ex. collagène, élastine, laminine, fibronectine, vitronectine, globuline insoluble à froid [CIG]
A61P 17/02 - Médicaments pour le traitement des troubles dermatologiques pour traiter les blessures, les ulcères, les brûlures, les cicatrices, les cheloïdes, ou similaires
A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]
83.
Biphasic electrolyte solution comprising kosmotropic metal salt
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Lee, Sang-Young
Kim, Won-Yeong
Kim, Hong-I
Abrégé
Provided is a biphasic electrolyte solution including: an aqueous electrolyte solution layer including a kosmotropic metal salt and water; and a nonaqueous electrolyte solution layer including a second metal salt and a nonaqueous organic solvent, and the biphasic electrolyte solution may provide a battery which satisfies both excellent battery performance and life characteristics.
SAMSUNG ELECTRONICS CO., LTD. (République de Corée)
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Lee, Ho Taik
Kim, Woochul
Kwon, Bok Soon
Kim, Sang Kyu
Park, Gimin
Kim, Sungho
Kim, Jiyong
Woo, Seungjai
Lee, So Young
Rhee, Hong Soon
Abrégé
An electronic device may include: a first temperature sensor configured to measure a first temperature of a skin surface when a user comes into contact with a main body of the electronic device; a first heating element spaced apart from the first temperature sensor by a first predetermined distance; a second temperature sensor spaced apart from the first heating element by a second predetermined distance and configured to measure a second temperature inside the main body; and a processor configured to: estimate heat flux based on the first temperature and the second temperature; estimate a blood perfusion rate of the user based on a temperature of the first heating element and the first temperature, and estimate a core body temperature of a user based on the first temperature, the estimated heat flux, and the estimated blood perfusion rate.
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Kim, Jae Hoon
Choi, Jung A
Chung, Joon Yong
Kim, Hyo Sun
Abrégé
The present specification provides a method for predicting the prognosis of endometrial cancer and a kit using same, the method comprising the steps of: detecting whether MSH2 or MSH6 is deficient in a biological sample isolated from an endometrial cancer patient; measuring a nectin-4 expression rate in the biological sample isolated from an endometrial cancer patient; and predicting an endometrial cancer prognosis of the endometrial cancer patient on the basis of the detected MSH2 or MSH6 deficiency and the measured nectin-4 expression rate. According to the present invention, when the nectin-4 expression rate is 3% or more in an MSH2- or MSH6-deficient patient group, there is the effect of predicting that the prognosis of endometrial cancer is poor.
C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer
Samsung Electronics Co., Ltd. (République de Corée)
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Yong, Jaecheon
Ko, Daehong
Abrégé
A semiconductor memory device including a semiconductor layer including a source area, a channel area, and a drain area arranged in a first horizontal direction on a substrate, a cell capacitor extending in the first horizontal direction on the substrate and including a lower electrode layer, a capacitor dielectric film, and an upper electrode layer connected to the source area, a bit line extending in a vertical direction on the substrate and connected to the drain area, and a gate structure covering the channel area, and the gate structure including a gate dielectric film on the channel area and a gate electrode film on the gate dielectric film, wherein in the vertical direction, a first thickness of an end of the channel area facing the source area is greater than a second thickness of another end of the channel area facing the drain area may be provided.
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Kim, Jae Hoon
Choi, Jung A
Chung, Joon Yong
Park, Young Hoon
Abrégé
Provided in the present specification are a method for diagnosing endometrial cancer using a nectin-4 expression rate, and a kit using same, the method comprising the steps of: measuring a nectin-4 expression rate in a biological sample isolated from an individual; and determining, on the basis of the measured nectin-4 expression rate, whether the individual has endometrial cancer. The present invention has the effect of providing a novel biomarker for the diagnosis, prediction, and evaluation of endometrial cancer.
G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer
C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
88.
METHOD FOR PREDICTING RESPONSE TO ANTICANCER IMMUNOTHERAPEUTIC AGENTS
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Kim, Jae-Woo
Cheong, Jae-Ho
Fang, Sungsoon
Yoon, Bo Kyung
Chun, Kyu-Hye
Abrégé
The present invention relates to a method for predicting the response to immunotherapeutic agents, comprising a step of measuring, in cancer cells or cancer tissue, the expression level of a dexamethasone-induced ras-related protein 1 (Dexras 1) gene or a protein encoded thereby. According to the present invention, research has been carried for prediction of the response to immunotherapeutic agents and, particularly, research has been carried out for prediction of the response to immunotherapeutic agents, highly reliable therapeutic agents and effective diagnosis of stem cell-like gastric cancer, which has the poorest prognosis and for which discovery of an effective treatment and diagnosis is difficult. As a result, it has been identified that in refractory carcinoma, the expression of Dexras 1 is high and, when an immunotherapeutic agent is injected, resistance to the immunotherapeutic agent is exhibited. In addition, changes in the expression level of Dexras 1 in cancer samples are measured such that immunotherapeutic agents for refractory cancer, such as stem cell-like gastric cancer that is difficult to be treated, are provided and refractory cancer can be diagnosed, and the response to anticancer immunotherapeutic agents for effective immunotherapy can be predicted such that the present invention has been completed. Therefore, the present invention is expected to be widely used in the development of novel therapeutic agents for refractory cancer.
C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer
A01K 67/027 - Nouvelles races ou races modifiées de vertébrés
C12N 15/85 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules animales
89.
Apparatus and method of acquiring image by employing color separation lens array
SAMSUNG ELECTRONICS CO., LTD. (République de Corée)
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Lee, Sangyun
Kang, Moongi
Yun, Seokho
Kim, Jonghyun
Jeong, Kyeonghoon
Abrégé
An apparatus for acquiring images includes an image sensor and a signal processor. The image sensor may include a sensor substrate and a color separation lens array, wherein the sensor substrate includes a plurality of photo-sensing cells, and the color separation lens array may separate an incident light into a plurality of lights having different wavelengths and forms a phase distribution for condensing the plurality of lights having the different wavelengths on adjacent photo-sensing cells of the plurality of photo-sensing cells. The signal processor may perform deconvolution on sensing signals of the plurality of photo-sensing cells to obtain a sub-sampled image, perform demosaicing to restore a full resolution image having a full resolution from the sub-sampled image, and correct a color of the full resolution image using a point spread function (PSF) of the color separation lens array.
G02B 27/10 - Systèmes divisant ou combinant des faisceaux
H04N 9/01 - Circuit de démodulation de signaux de composantes de couleur modulés spatialement par des filtres à bandes de couleur par séparation de phase
H04N 9/64 - Circuits pour le traitement de signaux de couleur
H04N 23/84 - Chaînes de traitement de la caméraLeurs composants pour le traitement de signaux de couleur
H04N 23/88 - Chaînes de traitement de la caméraLeurs composants pour le traitement de signaux de couleur pour l'équilibrage des couleurs, p. ex. circuits pour équilibrer le blanc ou commande de la température de couleur
H04N 25/13 - Agencement de matrices de filtres colorés [CFA]Mosaïques de filtres caractérisées par les caractéristiques spectrales des éléments filtrants
90.
EXOSOME-DERIVED BIOMARKER FOR DIAGNOSING COLON CANCER AND USE THEREOF
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Kim, Han Sang
Han, Yoon Dae
Seo, Yu Ra
Kim, Kyung A
Abrégé
The present specification provides a biomarker composition for diagnosing or predicting the prognosis of colon cancer and use thereof. A composition, a kit, and a method according to an embodiment enable diagnosis of colon cancer with high accuracy by using a sample containing exosomes, and accordingly, same can be useful in the field of colon cancer diagnosis.
G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer
C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
91.
METHOD AND DEVICE FOR DETERMINING WHETHER FACE IS FRONTAL FOR DYNAMIC SMILE ANALYSIS
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Kim, Jong Eun
Lee, Seulgi
Abrégé
A method and a device for determining whether a face is frontal for dynamic smile analysis are provided. The method comprises the steps of: extracting a plurality of landmarks within an image on the basis of a first algorithm based on artificial intelligence; calculating a plurality of parameters by using the plurality of facial landmarks; and determining whether a face in the image is in a frontal position, by using the plurality of parameters on the basis of a second algorithm based on artificial intelligence.
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Kim, Seong Taek
Abrégé
A sleep breathing disorder alleviation device and a sleep breathing disorder alleviation system according to the present invention, which are sleep breathing disorder alleviation devices for relieving a sleep breathing disorder by determining whether a user has a sleep breathing disorder, comprise: an oral unit that is mounted in the oral cavity of a user to move the mandible of the user depending on whether the user has a sleep breathing disorder; a control unit that receives information measured while the user is sleeping and controls the oral unit to relieve the sleep breathing disorder of the user according to the received information; and a sensing unit provided between the control unit and the nasal cavity of the user to sense information to determine whether the user has a sleep breathing disorder on the basis of the flow of air that the user breathes in and out while sleeping.
A61F 5/56 - Dispositifs pour prévenir le ronflement
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
G16H 40/40 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour la gestion d’équipement ou de dispositifs médicaux, p. ex. pour planifier la maintenance ou les mises à jour
G16H 40/60 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux
93.
BONE GRAFT MATERIAL AND BONE FORMATION METHOD USING SAME
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Park, Young Bum
Park, Jae Han
Choi, Hyun Min
Jung, Na Rae
Abrégé
The present invention relates to a bone graft material and a bone formation method using same and, more specifically, to a bone graft material and a bone formation method using same, wherein the bone graft material is designed such that, by impregnating a BMP-2 solution into a shield film that covers the upper surface of a bone defect and separates the bone defect from the outside so as to form a bone cover of the bone defect, a filler at the bottom of the shield film can sufficiently form bone in the cover.
A61L 27/44 - Matériaux composites, c.-à-d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent comportant une matrice macromoléculaire
A61L 27/42 - Matériaux composites, c.-à-d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent comportant une matrice inorganique
A61L 27/54 - Matériaux biologiquement actifs, p. ex. substances thérapeutiques
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Kim, Young Soo
Cho, Ill Hwan
Kim, Hye-Ju
Kim, Hye Yun
Abrégé
The present invention relates to methods for screening for a drug that interferes with or modulates binding between amyloid proteins and screening for a target domain of the drug. According to a method for screening for a candidate material for inhibiting or disaggregating amyloid protein aggregation, according to an aspect, the efficacy between previously known amyloid protein aggregation inhibitors or disaggregators can be compared, target domains of amyloid protein aggregation inhibitors or disaggregators can be analyzed, and furthermore, the mechanisms thereof can be verified. Thus, the method can be effectively used in the development of an inhibitor or disaggregator that specifically disaggregates the sequence of an amyloid protein, particularly Aβ protein.
SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION (République de Corée)
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Kim, Byung Soo
Jung, Mun Gyo
Kim, Young Soo
Lee, Song Min
Abrégé
The present invention may provide a pharmaceutical composition for the prevention or treatment of Alzheimer's disease, the composition containing: an amyloid-beta peptide or a nucleic acid encoding same; and rapamycin or a derivative thereof. The composition can generate antibodies against amyloid-beta to suppress the accumulation of amyloid-beta while inducing amyloid-beta-specific regulatory T cells to suppress inflammatory reactions in the brain affected by Alzheimer's disease. Therefore, the composition can be utilized as an Alzheimer's vaccine composition that is therapeutically excellent and preferably has few side effects.
A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
A61K 31/436 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à six chaînons ayant l'oxygène comme hétéro-atome du cycle, p. ex. rapamycine
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
96.
PYRIMIDINE DERIVATIVE HAVING PROTEIN KINASE INHIBITORY ACTIVITY, AND THERAPEUTIC PHARMACEUTICAL COMPOSITION COMPRISING SAME
INDUSTRAY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Lee, Koo
Chun, Kwangwoo
Lim, Sumin
Sim, Tae Bo
Sandip, Sengupta
Kim, Younghoon
Kim, Namkyoung
Jeon, Eunhye
Abrégé
The present invention relates to a pharmaceutical composition for preventing and treating cancers, including lung cancer, caused by abnormal cell growth, the composition containing, as active ingredients, a novel trisubstituted pyrimidine derivative having an inhibitory activity against protein kinases including EGFR, and a pharmaceutically acceptable salt thereof. The novel compound of the present invention has an excellent inhibitory activity against protein kinases. Particularly, the novel compound of the present invention has an excellent inhibitory effect on various drug-resistant EGFR mutants (EGFR mutants including exon 19 deletion-T790M-C797S-EGFR, L858R-T790M-C797S-EGFR, exon 19 deletion-C797S-EGFR, L858R-C797S-EGFR, exon 19 deletion-T790M-EGFR, L858R-T790M-EGFR, 19 deletion-EGFR and L858R-EGFR), and is useful as an agent for preventing and treating cancers caused by the EGFR mutants.
C07D 401/12 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
A61K 31/506 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime non condensées et contenant d'autres hétérocycles
A61K 31/541 - Thiazines non condensées contenant d'autres hétérocycles
A61K 31/5377 - 1,4-Oxazines, p. ex. morpholine non condensées et contenant d'autres hétérocycles, p. ex. timolol
A61K 31/55 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à sept chaînons, p. ex. azélastine, pentylènetétrazole
A61K 31/551 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à sept chaînons, p. ex. azélastine, pentylènetétrazole ayant deux atomes d'azote comme hétéro-atomes d'un cycle, p. ex. clozapine, dilazèpe
C07D 401/14 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant au moins trois hétérocycles
C07D 405/14 - Composés hétérocycliques contenant à la fois un ou plusieurs hétérocycles comportant des atomes d'oxygène comme uniques hétéro-atomes du cycle et un ou plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle contenant au moins trois hétérocycles
97.
DATA PROCESSING SYSTEM AND METHOD FOR ACCESSING HETEROGENEOUS MEMORY SYSTEM INCLUDING PROCESSING UNIT
SAMSUNG ELECTRONICS CO., LTD. (République de Corée)
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Jeong, Wonseb
Kal, Hongju
Ro, Won Woo
Lee, Seokmin
Ko, Gun
Abrégé
A data processing system and method for accessing a heterogeneous memory system including a processing unit are provided. The heterogeneous memory system includes a memory module and high bandwidth memory (HBM) including a processing-in-memory (PIM) circuit combined with a memory controller. The memory controller is configured to detect a data array required for an arithmetic operation from a memory module or the HBM by using a border index value when the arithmetic operation is performed by the PIM circuit of the HBM and generate a memory module command set and an HBM command set using physical address spaces respectively designated in the memory module and the HBM.
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Nam, Ki Taek
Park, Chang Ook
Jeong, Haengdueng
Abrégé
The present invention relates to a pharmaceutical composition for moisturizing the skin or treating diseases in which skin barrier are weakened, comprising an RhoA-activating factor as an active ingredient. The present invention relates to the development of a novel therapeutic agent that is effective for diseases, in which a skin barrier is disordered and weaken, such as atopic dermatitis and has no side effects, and thus can be effectively used for treating diseases in which a skin barrier is disordered since it has been identified that RAB25 gene is deficient in diseases in which a skin barrier is weaken, and skin is improved through the injection of an RhoA-activating factor.
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Cheong, Jae-Ho
Kim, Jae-Woo
Yoon, Bo Kyung
Abrégé
A composition according to the present invention is capable of inhibiting the growth of cancer cells and cancer stem cells, and also is capable of very effectively inhibiting the metastasis of cancer cells to other tissues. Thus, the composition may be very effectively used not only for the prevention, amelioration or treatment of cancer, but also for the inhibition of cancer metastasis.
A61K 31/4545 - Pipéridines non condensées, p. ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un cycle à six chaînons avec l'azote comme hétéro-atome du cycle, p. ex. pipampérone, anabasine
A61K 31/4525 - Pipéridines non condensées, p. ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un cycle à cinq chaînons avec l'oxygène comme hétéro-atome du cycle
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
100.
NOVEL ANTIBODY FOR PREVENTION OR TREATMENT OF FIBROTIC DISEASE
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (République de Corée)
Inventeur(s)
Yoon, Hogeun
Park, Soo-Yeon
Abrégé
The present invention relates to a method for prevention or treatment of fibrotic disease, wherein an antibody binding specifically to asporin protein involved in fibrosis is used for predicting the onset of fibrotic disease or for inhibiting the activity of the corresponding protein. The present invention provides an effective antibody that can be used for the diagnosis, prevention, and treatment of idiopathic pulmonary fibrosis, a condition for which efficient treatment methods have been absent because a clear pathogenic mechanism is not known therefor. In addition, the present invention can be advantageously used to effectively block fibrosis in various tissues by ultimately providing a fundamental inhibitory method for pathological fibrosis mechanisms.
C07K 16/18 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains
A61P 11/00 - Médicaments pour le traitement des troubles du système respiratoire
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps