Abrégé

The present invention relates to exosomes comprising an miRNA pool based on the inhibition of TGF-β signaling involved in cancer growth and metastasis. The exosomes, which are derived from tripartite motif containing 40 (TRIM40) transformed cells treated with staurosporine, comprise a pool of miRNAs that inhibit the expression of ECM- and EMT-related genes, the miRNAs include miR-1343-3p (which inhibits the expression of TGBR1 and TGFBR2), miR-4285 (which inhibits the expression of the TGFB1 gene), and miR-194-3p (which inhibits the TGF-beta signaling pathway), which inhibit the TGF-beta signaling pathway in cancer cells, thereby comprehensively blocking the expression of EMT- and ECM-related genes by surpassing a one-dimensional method of loading one specific miRNA or a small molecule that exhibits anticancer activity so as to inhibit TGF-beta signaling pathways when the miRNAs are absorbed and delivered into cancer cells, and thus the cancer microenvironment is modulated such that strong anticancer responses can be induced in preclinical settings.

Classes IPC  ?

• A61K 35/13 - Cellules tumorales, quel que soit le tissu d’origine
• A61K 31/7105 - Acides ribonucléiques naturels, c.-à-d. contenant uniquement des riboses liés à l'adénine, la guanine, la cytosine ou l'uracile et ayant des liaisons 3'-5' phosphodiester
• A61P 35/00 - Agents anticancéreux
• A61P 35/04 - Agents anticancéreux spécifiques pour le traitement des métastases
• A23L 33/10 - Modification de la qualité nutritive des alimentsProduits diététiquesLeur préparation ou leur traitement en utilisant des additifs
• A23L 33/13 - Acides nucléiques ou leurs dérivés

Abrégé

An embodiment of the present invention provides a technology for configuring a switch-capacitor direct current boosting device together with a thermoelectric element, thereby allowing the connection of a capacitor to vary in each of: a case in which the capacitor stores electricity due to the production of electricity by the thermoelectric element, and a case in which an electric device operates due to the discharge of electricity from the capacitor. A wearable device capable of switch-capacitor direct current boosting for efficient use of a wearable thermoelectric power generating element according to an embodiment of the present invention comprises: a thermoelectric element for generating electricity by contacting a user's body surface; an energy storage module connected to the thermoelectric element and having multiple capacitors for storing the electricity generated by the thermoelectric element; a switch module having multiple switch units and allowing one capacitor among the multiple capacitors and another capacitor to be connected in series or in parallel with each other; and a device unit for receiving electricity from the multiple capacitors when each of the multiple capacitors is connected in series by operation of the switch units.

Classes IPC  ?

• H02J 7/00 - Circuits pour la charge ou la dépolarisation des batteries ou pour alimenter des charges par des batteries
• H10N 10/80 - Détails de structure
• G06F 1/16 - Détails ou dispositions de structure

Abrégé

The present specification provides a method for providing information about colorectal cancer, and a kit and a drug screening method that are based thereon, the information provision method comprising the steps of: measuring the level of mRNA of an IgA maturation (IGAM) marker gene for a biological sample isolated from an individual, or the level of protein encoded by the mRNA; and determining the prognosis of colorectal cancer of the individual on the basis of the measured level of mRNA for the marker gene or the measured level of protein encoded by the mRNA.

Classes IPC  ?

• G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer
• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer

Abrégé

The present invention relates to a decellularized cancer tissue-derived extracellular matrix scaffold and a use thereof. The decellularized cancer tissue-derived extracellular matrix according to the present invention contains a large amount of a malignant tumor-related extracellular matrix and proliferation and metastasis components that are more distinct than existing mouse-derived scaffolds or decellularized normal tissue-derived scaffolds, thereby achieving a better cancer tissue-specific microenvironment. A cancer organoid cultured using the decellularized cancer tissue-derived extracellular matrix was found to have improved cancer-specific markers, proliferative capacity, size, and secretion of inflammatory cytokines, and better achieve a configuration and phenotype of cancer tissues at a level similar to the actual configuration and phenotype, and thus can be effectively used in disease modeling, drug screening, new drug toxicity evaluation, personalized drug selection, and the like.

Classes IPC  ?

• C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p. ex. lignées cellulairesTissusLeur culture ou conservationMilieux de culture à cet effet
• C12N 5/09 - Cellules tumorales
• G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique

Abrégé

One embodiment of the present invention provides a technique for using a wearable device worn on a finger of a user to measure the blood pressure of the user and use same to determine whether the user is a glaucoma suspect. A wearable device for monitoring glaucoma suspect, according to one embodiment of the present invention, comprises: a housing having a ring shape and having an inner space; a sensor unit coupled to the housing and contacting the skin of a user to measure pulse waves of the user; a communication unit for receiving and processing a signal of the sensor unit to generate a transmission signal which is a transmitted signal; and an analysis unit for receiving and analyzing the transmission signal.

Classes IPC  ?

• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• A61B 5/021 - Mesure de la pression dans le cœur ou dans les vaisseaux sanguins
• A61B 5/024 - Mesure du pouls ou des pulsations cardiaques
• A61B 5/02 - Détection, mesure ou enregistrement en vue de l'évaluation du système cardio-vasculaire, p. ex. mesure du pouls, du rythme cardiaque, de la pression sanguine ou du débit sanguin

Abrégé

The present invention comprises a method for providing information about demodex mites and a device based on the method, the method comprising the steps of: extracting a first feature of the demodex mites by inputting a face image of an individual to a trained first prediction model; generating a saliency map from the first feature; acquiring regions of interest in the face as one or more patches; extracting a second feature of the demodex mites by inputting the one or more patches to a second prediction model; and predicting a final density probability of the demodex mites for the individual by inputting the first feature and the second feature to a third prediction model trained to predict the density probability of the demodex mites for the individual.

Classes IPC  ?

• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
• G16H 50/50 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour la simulation ou la modélisation des troubles médicaux
• G16H 30/20 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le maniement d’images médicales, p. ex. DICOM, HL7 ou PACS

Abrégé

The present disclosure relates to a thermal runaway of lithium-ion battery detection and control device including: sensor modules for detecting and monitoring hydrogen concentrations of battery cells and each having a palladium-based nano sensor and a communication unit; and a battery cell controller for turning on and off charging/discharging switches of the battery cells according to the hydrogen concentrations detected through the sensor modules and variations in the hydrogen concentrations according to time, wherein the palladium-based nano sensor detects the hydrogen concentration between 20 and 400 ppm.

Classes IPC  ?

• G01N 27/12 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant l'impédance en recherchant la résistance d'un corps solide dépendant de l'absorption d'un fluideRecherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant l'impédance en recherchant la résistance d'un corps solide dépendant de la réaction avec un fluide
• B82Y 15/00 - Nanotechnologie pour l’interaction, la détection ou l'actionnement, p. ex. points quantiques comme marqueurs en dosages protéiques ou moteurs moléculaires
• G01N 33/00 - Recherche ou analyse des matériaux par des méthodes spécifiques non couvertes par les groupes
• H01M 10/42 - Procédés ou dispositions pour assurer le fonctionnement ou l'entretien des éléments secondaires ou des demi-éléments secondaires
• H01M 10/44 - Méthodes pour charger ou décharger

Abrégé

One of the most important technical problems to be solved in the present specification is that of providing a prime editor capable of exhibiting an actual therapeutic effect by selecting a prime editor exhibiting an effect of correcting c.4957dupA mutation of an EYS gene of actual human retinal cells from among numerous theoretically designable prime editors and specifying a configuration thereof. In order to solve this technical problem, the present specification provides a prime editor and a component thereof, wherein the prime editor is screened through a high-throughput screening method, is verified in actual human retinal cells, and can actually correct the c.4957dupA mutation of the EYS gene. The prime editor disclosed in the present specification acts on human retinal cells including the c.4957dupA mutation in the EYS gene, thereby being able to correct the EYS gene to a normal state. Therefore, the prime editor can be used as a therapeutic agent for retinitis pigmentosa caused by the c.4957dupA mutation in the EYS gene.

Classes IPC  ?

• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
• C12N 9/22 - Ribonucléases
• C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
• A61K 31/7088 - Composés ayant au moins trois nucléosides ou nucléotides
• A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
• A61P 27/02 - Agents ophtalmiques

Abrégé

The present disclosure relates to a method for isolating, maintaining, proliferating and differentiating monoclonal cells derived from human salivary gland epithelial stem cells or progenitor cells, and a production method for extracellular vesicles for treating salivary gland diseases. More specifically, conditions for isolating monoclonal salivary gland epithelial cells through an optimized subfractionation culturing method from a small amount of major salivary gland or minor salivary gland tissue obtained during surgery or biopsy processes have been established, and culture medium conditions for enabling long-term culture of salivary gland epithelial stem cells or progenitor cells in 2D have been established. Such high-purity monoclonal cells derived from human salivary gland epithelial stem cells or precursor cells are expected to be utilized not only as cell therapy products for fundamental treatment of salivary gland dysfunction and as candidates for extracellular vesicles, but also widely throughout salivary gland studies such as disease modeling, pathology research, drug screening, toxicity evaluation, and genetic manipulation.

Classes IPC  ?

• A61K 35/38 - EstomacIntestinCellules caliciformesMuqueuse oraleSalive
• C12N 5/071 - Cellules ou tissus de vertébrés, p. ex. cellules humaines ou tissus humains

Abrégé

The present invention relates to the discovery of an agent for measuring the expression level of a protein that induces the acquisition of metastatic ability by tumor cells, or a gene encoding the same, and a method for preventing or treating metastatic cancer by controlling the expression of the protein or gene. The present invention provides effective biomarkers for metastatic cancer that are capable of significantly improving the patient's survival rate when detected early, and provides a method capable of predicting with high reliability the likelihood that primary cancer will progress to metastatic cancer. Thus, the present invention may be useful for efficient prevention or treatment of metastatic cancer by inhibiting the expression of these factors.

Classes IPC  ?

• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
• G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer

Abrégé

Embodiments include a biogas production device including a conductive support-based dynamic biofilm with improved biogas productivity by using, as a support, a conductive support having a surface on which a dynamic biofilm of an electroactive microbial community is formed, and a biogas production method using the device. The biogas production device comprises: a reaction tank for producing an organic wastewater mixture by mixing organic wastewater and anaerobic microbial community formation to produce biogas; a dynamic biofilm module for filtering the organic wastewater mixture transferred from the reaction tank using a porous conductive support having a dynamic biofilm formed on a surface thereof; and a storage tank for measuring and storing an amount of biogas produced in the reaction tank.

Classes IPC  ?

• C02F 3/28 - Procédés de digestion anaérobies
• C02F 3/00 - Traitement biologique de l'eau, des eaux résiduaires ou des eaux d'égout
• C12P 3/00 - Préparation d'éléments ou de composés inorganiques à l'exception du dioxyde de carbone

Abrégé

The present invention provides a composition for differential diagnosis of urothelial papilloma, and an information provision method using same. By using the composition and the information provision method of the present invention, urothelial papilloma can be distinguished from low-grade urothelial carcinoma, which had been difficult to distinguish by tumor morphological shape in a conventional histopathological examination.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
• C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique

Abrégé

The present invention relates to a WKYMVm peptide analog comprising an amino acid sequence of Trp (W)-Lys (K)-Tyr (Y)-Met (M)-Val (V)-D-Met (m), in which at least one amino acid residue selected from the group consisting of Lys (K), Tyr (Y), and Met (M) in the amino acid sequence is substituted with a β3-amino acid residue or a peptoid residue, and a use thereof. The WKYMVm peptide analogs of the present invention has effects of increasing stability by increasing in vivo degradation half-life and of promoting activation of innate immune responses by neutrophils through activation of formyl peptide receptors, and thus can be effectively used in preventing or treating a disease that is be prevented or treated by formyl peptide receptors, especially an infectious disease or inflammatory disease.

Classes IPC  ?

• A61K 38/08 - Peptides ayant de 5 à 11 amino-acides
• C07K 7/02 - Peptides linéaires contenant au moins une liaison peptidique anormale

Abrégé

The present invention provides an endoscopic pipette and an observation system, the endoscopic pipette is configured to remove a culture medium accommodated in a culture vessel, in which spheroids are cultured, and observe the spheroids in the culture vessel, and the endoscopic pipette includes a tip unit configured to be inserted into the culture vessel to extract the culture medium, an accommodation unit configured to accommodate the culture medium extracted by the tip unit, a camera unit provided between the tip unit and the accommodation unit, disposed adjacent to the tip unit, and configured to capture an image of an interior of the culture vessel, and a power unit provided in a partial space of the accommodation unit and configured to provide power to the camera unit.

Classes IPC  ?

• B01L 3/02 - BurettesPipettes

Abrégé

The present disclosure relates to a cell obtaining method for creating NFT based on a cell image. The cell obtaining method includes the steps of separating a cell from a biological sample, obtaining a stem cell by treating the cell with a dedifferentiation inducer, differentiating the stem cell, acquiring an image of the differentiated cell; and converting the image of the differentiated cell into an NFT image, and creates the NFT using a vital image in a simple and easy way through non-invasive and non-medical procedures.

Classes IPC  ?

• C12N 5/077 - Cellules mésenchymateuses, p. ex. cellules osseuses, cellules de cartilage, cellules stromales médulaires, cellules adipeuses ou cellules musculaires
• C12N 5/0793 - Neurones

Abrégé

KLRB1KLRB1 mRNA or a protein encoded by the mRNA or CD161+ tissue-resident memory T cells as a marker for predicting a response to immunotherapy in HPV-induced cancer.

Classes IPC  ?

• G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer
• C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
• C12Q 1/6881 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour le typage de tissu ou de cellule, p. ex. sondes d’antigène leucocytaire humain [HLA]
• A61P 35/00 - Agents anticancéreux
• C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps

Abrégé

Disclosed are a DNA clock capable of recording long periods of time, comprising a composition for measuring or estimating elapsed time in cells, and a method of measuring or estimating elapsed time in cells using the composition.

Classes IPC  ?

• C12Q 1/6897 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques faisant intervenir des gènes rapporteurs liés de façon fonctionnelle à des promoteurs
• C12Q 1/6811 - Méthodes de sélection pour la production ou l’élaboration d’oligonucléotides spécifiques cibles ou de molécules de liaison
• C12Q 1/6874 - Méthodes de séquençage faisant intervenir des réseaux d’acides nucléiques, p. ex. séquençage par hybridation [SBH]

Abrégé

This application relates to a tumor tissue model in which tumor tissue isolated from a patient can be cultured. The tumor tissue model uses tumor tissue isolated from a patient, and thus the tumor tissue can be cultured while maintaining the extracellular matrix of tumor cells. Since the tumor tissue is cultured in an environment similar to the actual environment inside the body, the tumor tissue model can be used for patient-tailored drug screening, drug response evaluation, radiation reactivity evaluation, tumor-related research, clinical evaluation, animal replacement tests, disease modeling, etc.

Classes IPC  ?

• C12N 5/09 - Cellules tumorales

Abrégé

The present invention relates to a method by which a processor of a Demodex folliculorum prediction device provides information about Demodex folliculorum, and provides a method for providing information about Demodex folliculorum, and a device based thereon, the method comprising the steps of: receiving a face image of an individual; acquiring, as one or more patches, regions of interest in the face from the received face image; inputting the face image and each of the patches into a plurality of first density prediction models trained to input the face image and each of the patches so as to predict the density probability of Demodex folliculorum, thereby making a first prediction about the density probability of Demodex folliculorum for the face image and each of the patches; and inputting the density probability of Demodex folliculorum for the face image and each of the patches into a single second density prediction model trained to input the density probability of a plurality of Demodex folliculorums so as to predict the density probability of Demodex folliculorum for an individual, thereby making a second prediction about the density probability of the final Demodex folliculorum.

Classes IPC  ?

• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
• G16H 30/20 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le maniement d’images médicales, p. ex. DICOM, HL7 ou PACS
• G06N 20/20 - Techniques d’ensemble en apprentissage automatique

Abrégé

The present disclosure relates to a management system for generating and distributing a cell image-based NFT including a cell image generation unit that generates an image from a collected cell, an NFT issuance unit that converts the cell image into an NFT image and stores and manages the NFT image, and an NFT transaction unit that brokers an online transaction for the issued NFT, and a service providing method thereof, and may assign an asset value to a vital image to meet the demand for owning the image.

Classes IPC  ?

• G06V 20/69 - Objets microscopiques, p. ex. cellules biologiques ou pièces cellulaires
• G06F 21/10 - Protection de programmes ou contenus distribués, p. ex. vente ou concession de licence de matériel soumis à droit de reproduction
• H04L 9/32 - Dispositions pour les communications secrètes ou protégéesProtocoles réseaux de sécurité comprenant des moyens pour vérifier l'identité ou l'autorisation d'un utilisateur du système

Abrégé

The present invention relates to a composition for fixative exchange, comprising an organic catalyst and a platinum-based cross-linking agent. The composition of the present invention allows site-selective binding without interfering with Watson-Crick base pairs of nucleic acids and allows nucleic acids having reacted with a fixative to be restored to the state before reacting with the fixative, thereby enabling reverse transcription efficiency to be maximized, and thus can be effectively used in the field of diagnosing diseases or discovering a target material for new drug development through transcriptome analysis or multi-omics analysis from a single cell or a single nucleus.

Classes IPC  ?

• C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p. ex. pour test de réaction en chaîne par polymérase [PCR]
• C12Q 1/6869 - Méthodes de séquençage
• G01N 1/36 - Enrobage ou montage analogue d'échantillons

Abrégé

A composition comprising a decellularized uterine tissue-derived extracellular matrix and a use thereof and, more specifically, a hydrogel composition for three-dimensional culturing an endometrial organoid, a preparation method therefor, and a use thereof are described. The hydrogel composition comprising a decellularized uterine tissue-derived extracellular matrix can be utilized to fabricate an endometrial organoid highly similar to in vivo uterine tissues and organs through the properties, components, and physical properties of the decellularized uterine tissue-derived extracellular matrix, and such endometrial organoids can be advantageously used for in-vivo implantation and in drug tests for various uterus-related diseases.

Classes IPC  ?

• C12N 5/071 - Cellules ou tissus de vertébrés, p. ex. cellules humaines ou tissus humains
• C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p. ex. lignées cellulairesTissusLeur culture ou conservationMilieux de culture à cet effet

Abrégé

122) multiple emulsion.

Classes IPC  ?

• C11B 9/00 - Huiles essentiellesParfums
• B01J 13/02 - Fabrication de microcapsules ou de microbilles
• C08L 67/04 - Polyesters dérivés des acides hydroxycarboxyliques, p. ex. lactones

Abrégé

Provided herein are a method for providing information on recovery from acute kidney injury and a kit therefor, the method including the steps of: measuring a level of at least one amino acid of glutamine, glutamic acid, arginine, and tryptophan at a predetermined time with respect to a biological sample isolated from an individual; and determining whether there is a possibility of recovery from acute kidney injury (AKI) for the individual within a predetermined period of time on the basis of the measured level of amino acids.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
• G01N 33/70 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir la créatine ou la créatinine

Abrégé

A voltage measurement type glucose sensor comprises a microneedle array including a flat part and a plurality of microneedles located on one surface of the flat part; an enzyme layer located on a surface of the plurality of microneedles and including glucose oxidase; a supercapacitor located on the other side of the flat part; and a wireless communication module electrically connected to the supercapacitor, and a glucose measurement method using the same. The glucose sensor is self-driving without the need to apply separate external power, improving the lifespan of the device and enabling close monitoring of accurate glucose levels in real time,

Classes IPC  ?

• A61B 5/145 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang
• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• A61B 5/1486 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang en utilisant des procédés chimiques ou électrochimiques, p. ex. par des moyens polarographiques en utilisant des électrodes enzymatiques, p. ex. avec oxydase immobilisée

Abrégé

Please enter in the present application the English translation of the abstract of the Korean language application that was filed in the USPTO on Jun. 12, 2024, as contained in the English translation of the application in Appendix B of the Translator Certificate filed herewith, and as separately filed herewith in .docx format (728_Patent_Application_ABSTRACT.docx).

Classes IPC  ?

• C12N 9/78 - Hydrolases (3.) agissant sur les liaisons carbone-azote autres que les liaisons peptidiques (3.5)
• C12N 9/22 - Ribonucléases
• C12N 15/11 - Fragments d'ADN ou d'ARNLeurs formes modifiées
• C12Q 1/44 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une hydrolase une estérase

Abrégé

The present invention relates to a method for screening for an inhibitor against the blood-brain barrier passage of Cryptococcus neoformans, a method for screening for an antifungal agent, and an antifungal composition. The screening method of the present invention uses a novel gene that regulates the blood-brain barrier passage of Cryptococcus neoformans, and thus can effectively screen for an inhibitor against blood-brain barrier passage and an antifungal agent.

Classes IPC  ?

• C12Q 1/6851 - Amplification quantitative

Abrégé

Provided are: a peptide targeting Fusobacteria, comprising a peptide consisting of an amino acid sequence selected from the group consisting of SEQ ID NOs: 77 to 83; a composition for diagnosing cancer, comprising same; and a drug delivery composition. The peptide targeting Fusobacteria accurately targets Fusobacteria, which are harmful bacteria in various diseases, including cancer, and thus can be effectively used in cancer diagnosis and drug delivery.

Classes IPC  ?

• G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer
• C12N 7/00 - Virus, p. ex. bactériophagesCompositions les contenantLeur préparation ou purification
• G01N 33/569 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour micro-organismes, p. ex. protozoaires, bactéries, virus

Abrégé

Provided in one embodiment of the present invention is a polymer micelle having a micelle structure composed of an amphiphilic material with both a hydrophilic group and a hydrophobic group, wherein the hydrophilic group includes a polyglycerol functional group, and the hydrophobic group includes a phenol group having a hydrophobic substituent bonded to the end thereof and modified to be hydrophobic.

Classes IPC  ?

• C07C 41/03 - Préparation d'éthers à partir d'oxiranes par réaction d'un cycle oxirane avec un groupe hydroxyle
• C07C 43/23 - Éthers une liaison sur l'oxygène de la fonction éther étant sur un atome de carbone d'un cycle aromatique à six chaînons contenant des groupes hydroxyle ou O-métal

Abrégé

The present invention relates to a system for reducing noise of a CBCT image and a method therefor, wherein the system can reduce noise of a CBCT image by applying the difference between the CBCT image and a CT image to artificial intelligence learning by using CYCLE GAN so as to convert CBCT image data such that it has the same standards as CT image data and provide same, the CBCT image data having low quality and more noise than the CT image data.

Classes IPC  ?

• A61B 6/00 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations
• A61B 6/03 - Tomographie informatisée
• A61B 6/58 - Leur essai, réglage ou étalonnage
• G06T 7/10 - DécoupageDétection de bords

Abrégé

In an embodiment, gas emitted during DRI processing and melting is collected and blown in refining, and gas emitted from the refining is collected and used in DRI processing, so that it is possible to circulate gas input to and emitted from each process in a DRI-Smelter-BOF (Basic Oxygen Furnace) scheme and achieve process optimization.

Classes IPC  ?

• C21C 7/068 - Décarburation
• C21B 13/00 - Fabrication de fer spongieux ou d'acier liquide par des procédés directs
• C21B 13/12 - Fabrication de fer spongieux ou d'acier liquide par des procédés directs dans des fours électriques

Abrégé

An embodiment provides a method and a system device for refining molten iron, wherein hydrogen reduction DRI is utilized to collect CO2 gas generated during melting and further reduction and use the gas in decarbonization refining, so as to optimize processes and achieve carbon neutrality. In addition, it is possible to predict the end point of the decarbonization refining by measuring the amount of CO gas generated in decarbonization refining.

Classes IPC  ?

• C21B 13/00 - Fabrication de fer spongieux ou d'acier liquide par des procédés directs
• C21B 13/12 - Fabrication de fer spongieux ou d'acier liquide par des procédés directs dans des fours électriques

Abrégé

Provided is a Mott-piezo memristor of an ABO3/CO composition, which has maximized piezo characteristics by using a method, such as doping, with various elements, an ABO3 material having a perovskite structure exhibiting Mott-transition characteristics, and inserting a CO interlayer. The Mott-piezo memristor may comprise: a bottom electrode; a top electrode arranged to face the bottom electrode; and a plurality of Mott layers and a plurality of piezoelectric layers, which are arranged between the bottom electrode and the top electrode, wherein the plurality of piezoelectric layers are arranged between the plurality of Mott layers

Classes IPC  ?

• H10N 70/00 - Dispositifs à l’état solide n’ayant pas de barrières de potentiel, spécialement adaptés au redressement, à l'amplification, à la production d'oscillations ou à la commutation
• G06N 3/065 - Moyens analogiques
• H10N 70/20 - Dispositifs de commutation multistables, p. ex. memristors

Abrégé

Present disclosure provides an apparatus for manufacturing an artificial tissue, comprising: a hydrogel accommodating structure which accommodates hydrogel including cells and has a bottom plate, a container and a cover; and a standing wave adding means for adding a standing wave to the hydrogel accommodated in the hydrogel accommodating structure, wherein cells in the hydrogel are aligned by the adding of a standing wave, and the position of the cells in the hydrogel is controlled by adjusting at least one of the attenuation coefficient of the container and the reflection coefficient of the cover.

Classes IPC  ?

• C12M 1/42 - Appareils pour le traitement de micro-organismes ou d'enzymes au moyen d'énergie électrique ou ondulatoire, p. ex. magnétisme, ondes sonores
• B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
• C12M 1/12 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens de stérilisation, filtration ou dialyse
• C12M 3/00 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus

Abrégé

The present invention relates to a composition for preventing or treating inflammatory or autoimmune skin disease. The composition of the present invention may be useful as a fundamental therapeutic composition that is able to efficiently ameliorate skin tissue damage caused by inflammation while having a minimized impact on systemic immune activity by specifically inhibiting the activity of skin-specific T cells. The present invention also provides a screening method capable of quickly and highly reliably identifying promising therapeutic candidates that are able to alleviate various autoimmune and inflammatory damages occurring in skin tissue by inhibiting the activity of skin-specific T cells.

Classes IPC  ?

• A61K 31/517 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime condensées en ortho ou en péri avec des systèmes carbocycliques, p. ex. quinazoline, périmidine
• A61K 8/49 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant des composés hétérocycliques
• A61P 17/00 - Médicaments pour le traitement des troubles dermatologiques
• A61Q 17/00 - Préparations protectricesPréparations employées en contact direct avec la peau pour protéger des influences extérieures, p. ex. des rayons du soleil, des rayons X ou d'autres rayons nuisibles, des matériaux corrosifs, des bactéries ou des piqûres d'insectes
• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

Provided is a self-powered pressure sensor which may show excellent pressure sensitivity by significantly improving transfer efficiency of charges generated by triboelectrification, the sensor including: a first electrode; a first triboelectrification unit positioned on the first electrode; a second triboelectrification unit including a pattern on which a microstructure is repeatedly positioned, the microstructure being reversibly in contact with or separated from the first triboelectrification unit by a physical external force, and having at least one surface in contact with the first triboelectrification unit to induce a change in a contact area; and a second electrode positioned inside the second triboelectrification unit and conformally positioned on a surface of the microstructure, wherein the first electrode and the second electrode are geometrically asymmetric to each other.

Classes IPC  ?

• H02N 1/04 - Générateurs à friction
• A61B 5/024 - Mesure du pouls ou des pulsations cardiaques
• A61B 5/0245 - Mesure du pouls ou des pulsations cardiaques utilisant des capteurs engendrant des signaux électriques
• G01H 17/00 - Mesure des vibrations mécaniques ou des ondes ultrasonores, sonores ou infrasonores non prévue dans les autres groupes de la présente sous-classe

Abrégé

The present invention pertains to: an engineered cell comprising a chloroplast-containing cell and a conductor inserted into the cell, wherein the conductor is inserted so as to contact or penetrate the thylakoid membrane of the chloroplast, whereby the engineered cell is engineered so that photosynthetic electrons can be extracted out of the cell by light; a metal catalyst using the engineered cell; and a hydrogen production method using the engineered cell. By using the metal catalyst according to the present invention, oxygen generated during photosynthesis can be catalyzed and self-regulated at a low concentration and protons can be catalyzed to provide a hydrogen production system and method that enable sustained hydrogen production. In addition, the present invention has the effect of providing an artificial photosynthesis system which can convert sunlight into fuel by consuming only CO2 and water as electron sources and is especially superior in terms of cost efficiency and the immediate availability of the produced fuel.

Classes IPC  ?

• C12P 3/00 - Préparation d'éléments ou de composés inorganiques à l'exception du dioxyde de carbone
• C12N 1/12 - Algues unicellulairesLeurs milieux de culture
• C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie

Abrégé

The present invention relates to an autoimmune disease animal model and a method for preparing the same. The animal model of the present invention efficiently generates an autoantibody that causes autoimmune disease, by introducing an autoantigen-encoding gene through the Cre-LoxP system, which enables stable and continuous expression of the autoantigen at a desired time by treatment of Cre recombinase. Contrary to the conventional method that fails to effectively produce autoantibody due to leaky expression and immune tolerance, or requires repeated administration over several weeks, the present invention achieves sustainable expression of an effective amount of autoantigen by only one TAT-Cre recombinase treatment, thus may be utilized as an outstanding animal model reproducing various symptoms and molecular mechanisms of autoimmune diseases.

Classes IPC  ?

• A01K 67/027 - Nouvelles races ou races modifiées de vertébrés
• C07K 14/72 - RécepteursAntigènes de surface cellulaireDéterminants de surface cellulaire pour des hormones
• C12N 15/85 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules animales

Abrégé

An embodiment of the present invention provides a method for mechanochemical decomposition of polyvinyl chloride (PVC) using ball milling, the method comprising the steps of: ball milling PVC and a dechlorinating agent to obtain dechlorinated PVC; ball milling the dechlorinated PVC and an epoxidizing agent to obtain epoxidized PVC; and hydrolyzing the epoxidized PVC.

Classes IPC  ?

• C08J 11/26 - Récupération ou traitement des résidus des polymères par coupure des chaînes moléculaires des polymères ou rupture des liaisons de réticulation par voie chimique, p. ex. dévulcanisation par traitement avec une substance organique par traitement avec des composés organiques contenant de l'oxygène contenant des groupes acide carboxylique, leurs anhydrides ou esters
• C08F 216/06 - Alcool polyvinylique
• C08F 236/04 - Copolymères de composés contenant plusieurs radicaux aliphatiques non saturés et l'un au moins contenant plusieurs liaisons doubles carbone-carbone le radical ne contenant que deux doubles liaisons carbone-carbone conjuguées

Abrégé

A pyrimidine derivative, a method for preparing the pyrimidine derivative, and a pharmaceutical composition comprising the pyrimidine derivative are disclosed. Also disclosed is a method for preventing or treating cancer which includes administering the pyrimidine derivative or a composition containing the pyrimidine derivative to a subject in need of cancer treatment or prevention. The pyrimidine derivative exhibits a high inhibitory ability against EGFR mutation and HER2 mutation, and thus can be effectively used in treatment of cancer in which EGFR mutation and HER2 mutation have occurred

Classes IPC  ?

• C07D 239/48 - Deux atomes d'azote
• A61K 31/505 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime
• A61K 31/506 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime non condensées et contenant d'autres hétérocycles
• A61K 31/5377 - 1,4-Oxazines, p. ex. morpholine non condensées et contenant d'autres hétérocycles, p. ex. timolol
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
• C07D 401/12 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
• C07D 401/14 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant au moins trois hétérocycles
• C07D 403/12 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
• C07D 417/12 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre et d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons

Abrégé

The present invention relates to a conversion device for converting a treatment beam for treating a lesion of a subject, comprising: a collimator unit to which the treatment beam is incident and which has a plurality of slits; and a scattering unit that scatters the treatment beam that has passed through the collimator unit.

Classes IPC  ?

• A61N 5/10 - RadiothérapieTraitement aux rayons gammaTraitement par irradiation de particules

Abrégé

A system for determining a sputum type using a respiratory sound according to an embodiment may comprise a data collection unit that collects respiratory sound data from a patient who has undergone tracheostomy; an image conversion unit that receives the respiratory sound data collected by the data collection unit and converts the received respiratory sound data into a spectrogram image; and a sputum type determination unit that determines a sputum type of the patient who has undergone tracheostomy using a deep learning model based on a pattern difference between the spectrogram images converted by the image conversion unit.

Classes IPC  ?

• A61B 5/08 - Dispositifs de mesure pour examiner les organes respiratoires
• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus

Abrégé

The present invention relates to a pharmaceutical composition for preventing or treating liver disease comprising STC-1 or a derivative thereof as an active ingredient. The STC-1 protein according to the present invention reduces the expression of liver fibrosis markers ALT and Lect2 and reduces the area of fibrotic tissue, in animal models of liver fibrosis, indicating that it has excellent effects on the prevention and treatment of liver fibrosis and, furthermore, cirrhosis.

Classes IPC  ?

• A61K 38/22 - Hormones
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61P 1/16 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif des troubles de la vésicule biliaire ou du foie, p. ex. protecteurs hépatiques, cholagogues, cholélitholytiques

Abrégé

The present invention provides an antibacterial composition including two or more strains selected from the group consisting of Anaerostipes hadrus, Collinsella aerofaciens, Blautia wexlerae and Bifidobacterium longum strains that inhibit the activity of antibiotic-resistant bacteria.

Classes IPC  ?

• A61K 35/745 - Bifidobactéries
• A61P 31/04 - Agents antibactériens

Abrégé

The present invention relates to a composition for prevention or treatment of inflammatory or autoimmune skin diseases. The composition of the present invention may be useful as a fundamental therapeutic composition that is able to efficiently ameliorate skin tissue damage caused by inflammation while having a minimized impact on systemic immune activity by specifically inhibiting the activity of skin-specific T cells. In addition, the composition of the present invention may be efficiently delivered to the stratum corneum of the skin, so that it is able to exert a lesion-specific and intensive immune control effect as a composition for topical application to the skin. Moreover, it shows little toxicity to normal skin tissue, and thus is suitable even for long-term administration for the treatment of atopic dermatitis, a chronic disease. The present invention also provides, based on the newly identified correlation between skin-specific T cells and PIK3CD protein, a screening method capable of quickly and highly reliably identifying promising therapeutic candidates that are able to alleviate various autoimmune and inflammatory damages occurring in skin tissue.

Classes IPC  ?

• A61K 31/52 - Purines, p. ex. adénine
• A61P 17/00 - Médicaments pour le traitement des troubles dermatologiques
• A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]
• G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique

Abrégé

The present invention relates to a nucleic acid construct that can express and inhibit a gene simultaneously. The nucleic acid construct that can express and inhibit a gene simultaneously, according to the present invention, comprises both mRNA and siRNA in a single construct, and thus, mRNA and siRNA are introduced simultaneously into the same cell. Accordingly, a protein to be expressed may be expressed normally while expression of a particular gene may be specifically inhibited. The mRNA-siRNA nucleic acid construct activates an immune system by expressing a target protein in an antigen-presenting cell, and at the same time, overcomes interference of immune escape by blocking the activity of an immune checkpoint protein, and thus is expected to be remarkably useful in the fields of immunotherapy, especially in the field of cancer immunotherapy.

Classes IPC  ?

• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
• A61P 35/00 - Agents anticancéreux

Abrégé

The present invention relates to nanoparticles comprising a decellularized spleen extracellular matrix and use thereof and, in particular, to: nanoparticles having a uniform size, which are obtained by producing hydrogel from a decellularized spleen extracellular matrix, and then freeze-milling the hydrogel; a method for producing same; use thereof; and the like. The nanoparticles comprising a decellularized spleen extracellular matrix, according to the present invention, have many excellent advantages such as an immunity-enhancing effect, biocompatibility, safety, biodegradability, and usability, and thus can be used as a novel adjuvant for enhancing vaccine immunity.

Classes IPC  ?

• A61K 39/39 - Préparations médicinales contenant des antigènes ou des anticorps caractérisées par les additifs immunostimulants, p. ex. par les adjuvants chimiques
• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps

Abrégé

The present invention provides a pharmaceutical composition, an antibacterial composition, a probiotic composition, and a food additive composition, which are for treating or preventing inflammatory diseases, and contain, as an active ingredient, any one from among a Lactobacillus animalis strain and a Limosilactobacillus reuteri strain, which have an ability to adjust uric acid concentration, mixed strains (accession number: KCTC 15190BP) of the Lactobacillus animalis and Limosilactobacillus reuteri strains, a culture medium of the Lactobacillus animalis strain, a culture medium of the Limosilactobacillus reuteri strain, and a culture medium of the mixed strains (accession number: KCTC 15190BP).

Classes IPC  ?

• C12N 1/20 - BactériesLeurs milieux de culture
• A61K 35/747 - Lactobacilles, p. ex. L. acidophilus ou L. brevis
• A61P 31/04 - Agents antibactériens
• A01N 63/20 - BactériesSubstances produites par des bactéries ou obtenues à partir de celles-ci
• A01P 1/00 - DésinfectantsComposés antimicrobiens ou leurs mélanges
• A23L 33/135 - Bactéries ou leurs dérivés, p. ex. probiotiques
• C12R 1/225 - Lactobacillus

Abrégé

A multiple and broadband stealth structure comprises a radar absorption unit that absorbs broadband microwave, a low-frequency transmission filter unit that is stacked on an upper portion of the radar absorption unit, and an infrared radiation unit that is combined with the low-frequency transmission filter unit to selectively emit infrared ray, thereby selectively controlling the infrared emissivity of the surface to emit infrared radiation only through an atmospheric absorption window with a low infrared transmittance and to avoid the infrared detection system.

Classes IPC  ?

• F41H 3/00 - Camouflage, c.-à-d. moyens ou procédés de dissimulation ou de simulation
• B64D 7/00 - Agencement à bord aéronefs des équipements militaires, p. ex. des armes, des accessoires d'armement ou des blindages de protectionAdaptations des installations d'armement aux aéronefs

Abrégé

A hydrogel including phenol derivative-modified cellulose, a use thereof, and a preparation method therefor are described. Physical properties of the hydrogel can be modulated by adjusting concentrations of and oxidation conditions for the phenol derivative-modified cellulose. In addition, the hydrogel of the present invention can find applications in various fields due to its properties, such as hemostasis, blood coagulation acceleration, tissue adhesion, cell culture, cell transplantation, drug delivery, etc.

Classes IPC  ?

• A61L 24/00 - Adhésifs ou ciments chirurgicauxAdhésifs pour dispositifs de colostomie
• A61K 9/06 - OnguentsExcipients pour ceux-ci
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
• A61K 47/18 - AminesAmidesUréesComposés d’ammonium quaternaireAcides aminésOligopeptides ayant jusqu’à cinq acides aminés
• A61K 47/38 - CelluloseSes dérivés
• A61L 24/08 - Polysaccharides
• A61L 27/20 - Polysaccharides
• A61L 27/38 - Cellules animales
• A61L 27/52 - Hydrogels ou hydrocolloïdes
• C08B 15/06 - Dérivés contenant des éléments autres que carbone, hydrogène, oxygène, halogènes ou soufre contenant de l'azote
• C08B 15/10 - Réticulation de la cellulose
• C08J 3/075 - Gels macromoléculaires
• C08J 3/24 - Réticulation, p. ex. vulcanisation, de macromolécules
• C08L 1/08 - Dérivés de la cellulose

Abrégé

A heat flux sensor according to an embodiment of the present disclosure includes: a thermogalvanic cell; a first electrode and a second electrode which are respectively disposed on a first surface and a second surface of the thermogalvanic cell; and a processor configured to estimate heat flux by measuring a voltage, generated by a temperature difference between the first surface and the second surface, by using the first electrode and the second electrode, wherein core body temperature may be estimated based on the heat flux, estimated by the heat flux sensor, and a skin surface temperature of an object.

Classes IPC  ?

• G01K 13/20 - Thermomètres médicaux par contact pour les humains ou les animaux
• G01K 7/02 - Mesure de la température basée sur l'utilisation d'éléments électriques ou magnétiques directement sensibles à la chaleur utilisant des éléments thermo-électriques, p. ex. des thermocouples
• G01K 17/00 - Mesure d'une quantité de chaleur

Abrégé

Disclosed are a transparent electrode for a solar cell and a method of manufacturing the same. The transparent electrode for a solar cell has a low Young's modulus, excellent elasticity, self-healing properties, an average visible-light transmittance sufficient to implement bifacial properties, and excellent power conversion efficiency (PCE). In addition, the method of manufacturing the transparent electrode for a solar cell does not require an additional deposition process, so the electrode-manufacturing time can be reduced, and the electrode-manufacturing process can be performed separately from other solar-cell-manufacturing processes, which is advantageous for mass production and large-area application.

Classes IPC  ?

• H01G 9/20 - Dispositifs photosensibles
• H01G 9/00 - Condensateurs électrolytiques, redresseurs électrolytiques, détecteurs électrolytiques, dispositifs de commutation électrolytiques, dispositifs électrolytiques photosensibles ou sensibles à la températureProcédés pour leur fabrication
• H01G 9/042 - Électrodes caractérisées par le matériau

Abrégé

The present disclosure relates to a color change dye prepared by impregnating hollow silica with a dye having a cationic dye and an anionic dye prepared using ion pairing, a sensor for detecting gas containing the above dye and a method for preparing the same, and more specifically to, a sensor that increases sensitivity and stability by increasing the area where the dye touches the gas and protecting the dye itself, since cationic dyes and anionic dyes are ion-paired to increase humidity resistance and react only with a trace amount of acetone. and the ion-paired dyes are then impregnated into hollow silica, and a method for preparing the same.

Classes IPC  ?

• G01N 21/29 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en utilisant la détection visuelle
• G01N 33/00 - Recherche ou analyse des matériaux par des méthodes spécifiques non couvertes par les groupes

Abrégé

A memory device accessed by circuits operating based on a first supply voltage. The memory device includes a cell array electrically connected to a plurality of word lines and a plurality of bit lines; a row driver configured to select one word line of the plurality of word lines based on a row address; a precharge circuit configured to precharge the plurality of bit lines based on the first supply voltage; a column driver configured to select at least one bit line of the plurality of bit lines based on a column address; and a read circuit configured to read data stored in the cell array through the at least one bit line. The cell array, the row driver, the column driver, and the read circuit operate based on a second supply voltage, which is higher than the first supply voltage.

Classes IPC  ?

• G11C 11/419 - Circuits de lecture-écriture [R-W]
• G11C 11/418 - Circuits d'adressage

Abrégé

The present invention relates to a facial image-based method for providing information about a headache, and an apparatus using same, wherein the facial image-based method, which is implemented by a processor, comprises the steps of: receiving facial image data from a user device; determining landmark-identified facial image data with the facial image data as input, by using a landmark identification model configured to output the landmark-identified facial image data with the facial image data as input; and determining user headache data with the landmark-identified facial image data as input, by using a headache determination model configured to output the user headache data with the landmark-identified facial image data as input.

Classes IPC  ?

• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
• G16H 50/50 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour la simulation ou la modélisation des troubles médicaux
• G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p. ex. l’édition

Abrégé

A composition and method according to the present invention may be very effectively used to diagnose malignant gastric cancer and predict the prognosis of gastric cancer.

Classes IPC  ?

• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
• G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer

Abrégé

A wearable electronic device is provided. The wearable electronic device includes a housing, a printed circuit board disposed inside the housing and including wireless communication circuitry and a ground part, and an antenna disposed inside the housing and electrically connected to the wireless communication circuitry, wherein the antenna includes a conductive pattern, a feeding member electrically connected to the wireless communication circuitry through a feeding point and configured to electrically connect a first point of the conductive pattern and a first point of the ground part, a short-circuit member configured to electrically connect a second point of the conductive pattern and a second point of the ground part, and a capacitive loading member disposed between the feeding member and the short-circuit member having a first part operatively coupled to a third point of the conductive pattern and a second part electrically connected to a third point of the ground part.

Classes IPC  ?

• H01Q 7/00 - Cadres ayant une distribution du courant sensiblement uniforme et un diagramme de rayonnement directif perpendiculaire au plan du cadre
• H01Q 1/22 - SupportsMoyens de montage par association structurale avec d'autres équipements ou objets
• H01Q 1/27 - Adaptation pour l'utilisation dans ou sur les corps mobiles
• H01Q 5/25 - Systèmes à ultralarge bande, p. ex. systèmes à résonnance multipleSystèmes à impulsions

Abrégé

Proposed are a phlegm suction alarm issuing apparatus and a method for a tracheostomy patient which monitor and analyze a respiratory sound of the tracheostomy patient in real time, then check congestion of phlegm, and issue a phlegm suction alarm.

Classes IPC  ?

• A61M 16/04 - Tubes trachéaux
• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• A61B 5/08 - Dispositifs de mesure pour examiner les organes respiratoires

Abrégé

This vest-type speaker device comprises: a communication unit; at least one speaker positioned corresponding to the user's lung; a memory; and a processor for controlling the operation of a battery, wherein the processor is configured to receive a control signal based on user condition information from an external electronic device through the communication unit, and output sound waves and vibrations through the at least one speaker on the basis of the control signal.

Classes IPC  ?

• A61H 23/02 - Massage par percussion ou vibration, p. ex. en utilisant une vibration ultrasoniqueMassage par succion-vibrationMassage avec des membranes mobiles à entraînement électrique ou magnétique
• A61M 16/00 - Dispositifs pour agir sur le système respiratoire des patients par un traitement au gaz, p. ex. ventilateursTubes trachéaux
• H04R 1/32 - Dispositions pour obtenir la fréquence désirée ou les caractéristiques directionnelles pour obtenir la caractéristique directionnelle désirée uniquement
• G06N 3/08 - Méthodes d'apprentissage
• A61B 6/00 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations
• A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiquesMesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p. ex. formation d'images par résonance magnétique
• A61B 6/03 - Tomographie informatisée

Abrégé

The present invention relates to a forearm fixing apparatus for a therapeutic robot for restoring and maintaining the range of motion of joints of an upper extremity, comprising: a fixing unit in which the forearm of a user is fixed to one surface thereof; a handle that is provided to be inclined on one surface of the fixing unit and gripped by a hand of the user; a plurality of frames provided at intervals on the other surface of the fixing unit; and a connector that is detachably coupled to any one of the plurality of frames and provided on a robot arm.

Classes IPC  ?

• A61H 1/02 - Appareils d'exercice extenseurs ou de ployage
• B25J 18/00 - Bras

Abrégé

The present invention relates to a method for prevention, alleviation, or treatment of cancer patients, especially epithelial mesenchymal transition (EMP)-subtype cancer patients. If PHGDH, SHMT and MTHFD2 inhibitors are co-administered to patients with cancer in which the expression level of a glutaminase (GLS) gene or a protein encoded thereby has increased, 1C metabolism is more effectively inhibited such that there is a synergistic effect on the inhibition of cancer cell proliferation in patients with refractory cancer that is difficult to treat because of recurrence, metastasis, and anticancer drug resistance, thereby enabling cancer to be very effectively treated. In addition, the expression level of the GLS gene or protein encoded thereby is measured so that information related to customized treatment methods from initial stages is provided to each patient and the success of treatment can be increased.

Classes IPC  ?

• A61K 31/501 - PyridazinesPyridazines hydrogénées non condensées et contenant d'autres hétérocycles
• A61K 31/496 - Pipérazines non condensées contenant d'autres hétérocycles, p. ex. rifampine, thiothixène ou sparfloxacine
• A61P 35/00 - Agents anticancéreux
• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer

Abrégé

The present invention relates to a composition for treating inflammatory diseases comprising germanium telluride nanosheets coated with polyvinylpyrrolidone, and the nanosheets have excellent anti-inflammatory and thus are excellent in treating inflammatory bowel disease and psoriasis.

Classes IPC  ?

• A61K 33/24 - Métaux lourdsLeurs composés
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 9/28 - DragéesPilules ou comprimés avec revêtements
• A61K 9/51 - Nanocapsules
• A61K 33/00 - Préparations médicinales contenant des ingrédients actifs inorganiques
• A61K 33/04 - Soufre, sélénium ou tellureLeurs composés
• A61P 1/04 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif des ulcères, des gastrites ou des œsophagites par reflux, p. ex. antiacides, antisécrétoires, protecteurs de la muqueuse
• A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]
• A61P 37/00 - Médicaments pour le traitement des troubles immunologiques ou allergiques

Abrégé

The present invention relates to a gas turbine blade having a shelf squealer tip, the gas turbine blade including an airfoil-shaped blade housing, and a squealer tip extending from an edge portion of a tip surface that is an end surface of the blade housing, in which the squealer tip is formed only on a part of the edge portion of the tip surface. According to the present invention, it is possible to maximize film-cooling performance on the tip surface and additionally reduce an aerodynamic loss by suppressing high-temperature main flow reattachment and swirl flow generation on the tip surface.

Classes IPC  ?

• F01D 5/20 - Extrémités de pales spécialement façonnées en vue d'obturer l'espace entre ces extrémités et le stator
• F01D 5/14 - Forme ou structure
• F01D 5/18 - Aubes creusesDispositifs de chauffage, de protection contre l'échauffement ou de refroidissement des aubes

Abrégé

Provided is a gold-doped nickel nanocluster having a specific number of gold atoms, nickel atoms, and organothiol-based ligands. The gold atoms, the nickel atoms, and the organothiol-based ligands are bonded in a specific structure, a method for manufacturing the same, an electrode for converting carbon dioxide including the same, and a method for converting carbon dioxide using the same.

Classes IPC  ?

• C25B 11/095 - Électrodes comportant des électro-catalyseurs sur un substrat ou un support caractérisées par le matériau électro-catalytique formé d’au moins un élément catalytique et d’au moins un composé catalytiqueÉlectrodes comportant des électro-catalyseurs sur un substrat ou un support caractérisées par le matériau électro-catalytique formé de plusieurs éléments catalytiques ou composés catalytiques au moins un des composés est de type organique
• C25B 3/26 - Réduction du dioxyde de carbone

Abrégé

The present invention relates to a pharmaceutical composition for preventing and treating a cancer disease, including lung cancer, caused by abnormal cell growth containing a novel trisubstituted pyrimidine derivative with inhibitory activity against protein kinases, including EGFR, and a pharmaceutically acceptable salt thereof as active ingredients. The novel compound of the present invention has strong inhibitory activity against protein kinases. Particularly, the novel compound of the present invention has potent inhibitory effects against various drug-resistant EGFR mutants (including exon 19 deletion-T790M-C797S-EGFR, L858R-T790M-C797S-EGFR, exon 19 deletion-T790M-EGFR, and L858R-T790M-EGFR) and is useful as a prophylactic and therapeutic agent for cancer diseases caused by these EGFR mutants.

Classes IPC  ?

• C07D 401/12 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 9/20 - Pilules, pastilles ou comprimés
• A61K 9/48 - Préparations en capsules, p. ex. de gélatine, de chocolat
• A61K 31/506 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime non condensées et contenant d'autres hétérocycles
• A61K 31/53 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec trois azote comme seuls hétéro-atomes d'un cycle, p. ex. chlorazanil, mélamine
• A61K 31/5377 - 1,4-Oxazines, p. ex. morpholine non condensées et contenant d'autres hétérocycles, p. ex. timolol
• A61K 31/541 - Thiazines non condensées contenant d'autres hétérocycles
• A61K 31/55 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à sept chaînons, p. ex. azélastine, pentylènetétrazole
• A61K 31/551 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à sept chaînons, p. ex. azélastine, pentylènetétrazole ayant deux atomes d'azote comme hétéro-atomes d'un cycle, p. ex. clozapine, dilazèpe
• A61K 31/675 - Composés du phosphore ayant l'azote comme hétéro-atome d'un cycle, p. ex. phosphate de pyridoxal
• A61K 47/02 - Composés inorganiques
• A61K 47/26 - Hydrates de carbone, p. ex. polyols ou sucres alcoolisés, sucres aminés, acides nucléiques, mono-, di- ou oligosaccharidesLeurs dérivés, p. ex. polysorbates, esters d’acide gras de sorbitan ou glycyrrhizine
• C07D 239/48 - Deux atomes d'azote
• C07D 401/14 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant au moins trois hétérocycles
• C07D 405/14 - Composés hétérocycliques contenant à la fois un ou plusieurs hétérocycles comportant des atomes d'oxygène comme uniques hétéro-atomes du cycle et un ou plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle contenant au moins trois hétérocycles
• C07D 417/14 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre et d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant au moins trois hétérocycles
• C07F 9/6558 - Composés hétérocycliques, p. ex. contenant du phosphore comme hétéro-atome du cycle contenant au moins deux hétérocycles différents ou différemment substitués ni condensés entre eux ni condensés avec un carbocycle commun ou un système carbocyclique commun

Abrégé

The present application relates to a vector for delivering an active agent to the nervous system. In one embodiment of the present application, a vector for delivering an active agent in which one or more TTR ligands are conjugated to the surface of an adeno-associated virus is provided.

Classes IPC  ?

• A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
• A61K 47/69 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament le conjugué étant caractérisé par sa forme physique ou sa forme galénique, p. ex. émulsion, particule, complexe d’inclusion, stent ou kit
• C12N 15/86 - Vecteurs viraux

Abrégé

The present invention is applicable as a biomarker for allergic rhinitis, enabling easy distinction from normal people by detecting has-let-7a-5p, which is a micro RNA present in exosomes, by using nasal washing fluid that can be non-invasively obtained. Furthermore, the present invention can also be used as a therapeutic agent for allergic rhinitis due to use of the mechanism of suppressing mucus hypersecretion when let-7a-5p is overexpressed.

Classes IPC  ?

• C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique

Abrégé

The present disclosure is to control signals by using a metasurface in a wireless communication system. An operating method of a communication apparatus may comprise the steps of: generating at least one codeword by encoding information bits; generating modulation symbols on the basis of the at least one codeword; mapping the modulation symbols to at least one layer; and transmitting signals including the modulation signals mapped to the at least one layer. The signals may include a first signal transmitted to a first apparatus located in a first direction and a second signal transmitted to a second apparatus located in a second direction, and the first signal and the second signal may be transmitted in the first direction and the second direction by outputting the first signal and the second signal toward a plurality of unit cells and independently applying phase change patterns, which are generated by the plurality of unit cells, to the first signal and the second signal, respectively.

Classes IPC  ?

• H04B 7/145 - Systèmes relais passifs
• H04B 7/0413 - Systèmes MIMO
• H01Q 3/30 - Dispositifs pour changer ou faire varier l'orientation ou la forme du diagramme de directivité des ondes rayonnées par une antenne ou un système d'antenne faisant varier la phase relative ou l’amplitude relative et l’énergie d’excitation entre plusieurs éléments rayonnants actifsDispositifs pour changer ou faire varier l'orientation ou la forme du diagramme de directivité des ondes rayonnées par une antenne ou un système d'antenne faisant varier la distribution de l’énergie à travers une ouverture rayonnante faisant varier la phase
• H01Q 15/14 - Surfaces réfléchissantesStructures équivalentes
• H01Q 21/24 - Combinaisons d'unités d'antennes polarisées dans des directions différentes pour émettre ou recevoir des ondes polarisées circulairement ou elliptiquement ou des ondes polarisées linéairement dans n'importe quelle direction

Abrégé

Disclosed are a server for predicting incidence of a moyamoya disease through learning of a fundus image, and a method thereof. The server according to an embodiment of the present disclosure labels input fundus images as a moyamoya disease patient with the moyamoya disease and a normal patient without the moyamoya disease, learns the incidence prediction model by recognizing fundus images labeled as the moyamoya disease patient and fundus images labeled as the normal patient into the incidence prediction model, and predicts the incidence probability of the moyamoya disease by inputting the new fundus image into the learned incidence prediction model when a new fundus image is input.

Classes IPC  ?

• G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
• G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p. ex. pour des dossiers électroniques de patients
• G16H 30/20 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le maniement d’images médicales, p. ex. DICOM, HL7 ou PACS
• G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p. ex. l’édition
• G16H 50/70 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour extraire des données médicales, p. ex. pour analyser les cas antérieurs d’autres patients

Abrégé

This method for determining prosthetic options for an implant comprises the steps of: obtaining an implant image comprising an implant fixture region; identifying an implant manufacturer on the basis of the implant image by using a first machine learning model; estimating detailed specifications of an implant fixture on the basis of the implant fixture region by using a second machine learning model, and identifying an implant model corresponding to the detailed specifications; and determining a prosthetic option corresponding to the diameter of the upper portion of the implant fixture with reference to a database.

Classes IPC  ?

• A61C 13/00 - Prothèses dentairesLeurs procédés de fabrication
• G06N 20/00 - Apprentissage automatique
• A61C 9/00 - Méthodes de prise d'empreintes spécialement conçues pour les prothèses dentairesPorte-empreintes à cet effet
• G06N 3/08 - Méthodes d'apprentissage
• G06T 1/00 - Traitement de données d'image, d'application générale
• G06T 17/00 - Modélisation tridimensionnelle [3D] pour infographie
• G16H 50/50 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour la simulation ou la modélisation des troubles médicaux
• G16H 30/00 - TIC spécialement adaptées au maniement ou au traitement d’images médicales
• A61C 8/00 - Moyens destinés à être fixés à l'os de la mâchoire pour consolider les dents naturelles ou pour y assujettir des prothèses dentairesImplants dentairesOutils pour l'implantation

Abrégé

A display device includes a display panel, a first auxetic structure including a first pattern that defines a plurality of first openings, overlapping the display panel, and having a negative Poisson's ratio, a second auxetic structure including a second pattern that defines a plurality of second openings, overlapping the first auxetic structure, and having a negative Poisson's ratio, and a support layer disposed below the display panel and supporting the display panel.

Classes IPC  ?

• H05K 5/02 - Enveloppes, coffrets ou tiroirs pour appareils électriques Détails

Abrégé

The present invention relates to a composition for diagnosing endometriosis, the composition comprising an agent for measuring the level of miRNA as an active ingredient. The present invention was developed in an effort to overcome the conventional diagnostic difficulties and treatment limitations associated with endometriosis. As a result, during the search for new diagnostic targets in endometrial cells isolated from healthy controls and patients with endometriosis, a difference in the expression of miRNA within exosomes was identified. It was found that the expression of miRNA within exosomes isolated from patients with endometriosis significantly increased or decreased compared to healthy controls, leading to the completion of the present invention. The composition can be advantageously utilized as a diagnostic and therapeutic agent for endometriosis.

Classes IPC  ?

• C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique
• A61K 31/7105 - Acides ribonucléiques naturels, c.-à-d. contenant uniquement des riboses liés à l'adénine, la guanine, la cytosine ou l'uracile et ayant des liaisons 3'-5' phosphodiester
• A61P 15/02 - Médicaments pour le traitement des troubles génitaux ou sexuelsContraceptifs pour les pathologies du vagin

Abrégé

2522O).

Classes IPC  ?

• A61K 6/77 - Verre
• A61K 6/80 - Préparations pour la fabrication de dents artificielles, l’obturation ou le recouvrage des dents

Abrégé

The present invention relates to a composition for preventing, ameliorating and treating skin damage, comprising, as an active ingredient, (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate or a pharmaceutically acceptable salt thereof. When the composition of the present invention is administered, collagen synthesis in the dermal layer of the skin is promoted and thus it is possible to more effectively treat and ameliorate skin damage caused by particulate matter.

Classes IPC  ?

• A61K 8/49 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant des composés hétérocycliques
• A61Q 19/00 - Préparations pour les soins de la peau
• A61Q 19/08 - Préparations contre le vieillissement
• A23L 33/10 - Modification de la qualité nutritive des alimentsProduits diététiquesLeur préparation ou leur traitement en utilisant des additifs
• A61K 31/366 - Lactones ayant des cycles à six chaînons, p. ex. delta-lactones
• A61P 17/00 - Médicaments pour le traitement des troubles dermatologiques

Abrégé

Provided herein are novel reprogrammed smooth muscle cells (rSMCs) and methods of making and using the cells for the treatment of ischemia. The rSMCs are produced by culturing a fibroblast with an all-trans-retinoic acid (ATRA) under conditions that produce the rSMC from the fibroblast, wherein the fibroblasts are genetically modified to overexpress myocardin. The rSMCs offer advantages over currently available regenerative vascular therapies by promoting vascular perfusion in a recipient subject. In particular, the rSMCs can increase neovascularization of both small and large vessels.

Classes IPC  ?

• C12N 5/077 - Cellules mésenchymateuses, p. ex. cellules osseuses, cellules de cartilage, cellules stromales médulaires, cellules adipeuses ou cellules musculaires
• C12N 5/10 - Cellules modifiées par l'introduction de matériel génétique étranger, p. ex. cellules transformées par des virus
• A61K 35/44 - VaisseauxCellules de muscles vasculaires lissesCellules endothélialesCellules progénitrices endothéliales
• A61K 35/34 - MusclesCellules musculaires lissesCœurCellules souches cardiaquesMyoblastesMyocytesCardiomyocytes
• C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p. ex. lignées cellulairesTissusLeur culture ou conservationMilieux de culture à cet effet
• C12N 5/071 - Cellules ou tissus de vertébrés, p. ex. cellules humaines ou tissus humains

Abrégé

The disclosed embodiment provides an OTFS system capable of improving transmission efficiency while maintaining high compatibility with respect to an OFDM system and performance gains of channel estimation and compensation of an existing OTFS system, and a transmission and reception method thereof, the OTFS system comprising: a sample compression precoder that receives an application of a QAM symbol of a size L x M (where L and N are natural numbers), and compresses and transforms the QAM symbol into a delay-Doppler (hereinafter, DD) symbol having a size M x N (which are natural numbers in which M < L) in a DD domain; a two-dimensional domain transform module that transforms the DD symbol into a time frequency (hereinafter, TF) symbol having a size M x N in a TF domain; and a modulator that transmits a transmission signal in a time domain, which is acquired by modulating the TF symbol.

Classes IPC  ?

• H04L 27/26 - Systèmes utilisant des codes à fréquences multiples
• H04L 27/36 - Circuits de modulationCircuits émetteurs
• H04L 27/01 - Égaliseurs
• H04L 25/03 - Réseaux de mise en forme pour émetteur ou récepteur, p. ex. réseaux de mise en forme adaptatifs

Abrégé

The present invention relates to a dual capsule for fecal microbiota transplantation and a manufacturing method therefor. When being orally administered, the dual capsule for fecal microbiota transplantation of the present invention makes it possible to suppress multi-drug resistant bacteria within the body and can be utilized for the prevention or treatment of infections of multi-drug resistant bacteria.

Classes IPC  ?

• A61K 9/50 - Microcapsules
• A61K 35/74 - Bactéries
• A61P 31/04 - Agents antibactériens
• A61P 43/00 - Médicaments pour des utilisations spécifiques, non prévus dans les groupes

Abrégé

Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related deaths worldwide, but lacks effective prognostic indicators. Methionyl-tRNA synthetase 1 (MARS1), which is an important enzyme in translation initiation for delivering Met to initiator tRNA, is associated with cancer development and progression. MARS1 expression was found to significantly increase in PDAC compared to normal pancreatic duct tissue. In addition, the high expression of MARS1 was found to be associated with poor prognosis in PDAC patients. This suggests that MARS1 is involved in pancreatic carcinogenesis and has potential as a novel prognostic indicator for PDAC.

Classes IPC  ?

• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
• G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer

Abrégé

The present invention relates to a precise measurement apparatus and method of skin moisture and, more specifically, to a precise measurement apparatus and method of skin moisture that is not affected by pressure applied to the apparatus. The precise measurement apparatus of skin moisture, according to an aspect of the present invention, may comprise: a main body that is open toward a to-be-measured object and has a hollow portion; a contact portion that is slidably movably mounted on the main body and has a window for being in contact with the to-be-measured object; and a connection portion that connects the main body and the contact portion and includes an elastic member provided so as to be compressed, when the contact portion slides into the main body.

Classes IPC  ?

• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• A61B 5/0507 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiquesMesure utilisant des micro-ondes ou des ondes radio utilisant des micro-ondes ou des ondes térahertz

Abrégé

Provided are a porous nanosheet and a method for manufacturing the same, and a porous nanosheet which may include holes on the surface while maintaining a two-dimensional nanosheet form and may significantly improve catalyst efficiency and economic feasibility while minimizing platinum usage by introducing a platinum single atom to the holes, and a method for manufacturing the same are provided.

Classes IPC  ?

• C25B 11/091 - Électrodes comportant des électro-catalyseurs sur un substrat ou un support caractérisées par le matériau électro-catalytique formé d’au moins un élément catalytique et d’au moins un composé catalytiqueÉlectrodes comportant des électro-catalyseurs sur un substrat ou un support caractérisées par le matériau électro-catalytique formé de plusieurs éléments catalytiques ou composés catalytiques
• C25B 1/04 - Hydrogène ou oxygène par électrolyse de l'eau
• C25B 11/031 - Électrodes poreuses

Abrégé

A semiconductor memory device includes a source layer, a semiconductor layer including a semiconductor protrusion structure, and a drain layer arranged in a first horizontal direction on a substrate, a cell capacitor extending in the first horizontal direction on the substrate and including a lower electrode layer, a capacitor dielectric film, and an upper electrode layer connected to the drain layer, a bit line extending in a vertical direction on the substrate and connected to the source layer, and a gate structure covering the semiconductor protrusion structure and including a gate dielectric film on the semiconductor protrusion structure and a gate electrode film on the gate dielectric film. A value of a first thickness of an end portion of the semiconductor protrusion structure facing the drain layer is greater than a value of a second thickness of another end portion of the semiconductor protrusion structure facing the source layer.

Classes IPC  ?

• H10B 12/00 - Mémoires dynamiques à accès aléatoire [DRAM]

Abrégé

The present invention relates to a method for manufacturing a photosensitive polymer film comprising a polymer material and a photosensitizer, and to a method for promoting cell proliferation and a method for separating cells, which comprise a step of irradiating the photosensitive polymer film with light. According to the photosensitive polymer film according to the present invention, all processes of cell culture, growth promotion, and cell sheet separation and delivery thereof are performed on a single photosensitive polymer film at once by controlling only the density and irradiation time of light energy, resulting in low costs, a simple procedure, and less time.

Classes IPC  ?

• C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p. ex. lignées cellulairesTissusLeur culture ou conservationMilieux de culture à cet effet
• C12N 5/077 - Cellules mésenchymateuses, p. ex. cellules osseuses, cellules de cartilage, cellules stromales médulaires, cellules adipeuses ou cellules musculaires

Abrégé

An audio signal processing method, which is executed by a processor electronically communicating with a deep neural network within a computing system, may comprise: acquiring, by the processor, an input signal before encoding and an output signal after quantization and decoding; calculating, by the processor, a perceptual global loss for a frame corresponding to the input and the output signals; acquiring, by the processor, a plurality of subframes corresponding to the input and output signals by applying a windowing function to the frame of the input and output signals; calculating, by the processor, perceptual local losses for the plurality of subframes corresponding to the input and output signals; and acquiring, by the processor, multi-time scale perceptual loss based on the perceptual global and local losses.

Classes IPC  ?

• G10L 19/005 - Correction d’erreurs induites par le canal de transmission, lorsqu’elles sont liées à l’algorithme de codage

Abrégé

Provided are a method of providing information on a rib fracture, and a device for providing information on a rib fracture by using same. The method of providing information on a rib fracture, implemented by a processor, comprises the steps of: receiving a chest medical image of a subject; extracting the chest medical image patch by patch; determining, by using a convolutional neural network model pretrained to determine rib fracture probability by using a patch as an input, rib fracture probability by using the patch as an input; generating a class activation map (CAM) patch by patch; and reconstructing the entire class activation map generated patch by patch, to correspond to the entire chest medical image.

Classes IPC  ?

• A61B 6/00 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations
• A61B 6/03 - Tomographie informatisée
• A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiquesMesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p. ex. formation d'images par résonance magnétique
• G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
• G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p. ex. l’édition
• G06N 3/08 - Méthodes d'apprentissage

Abrégé

The present disclosure relates to a method for discovering factors determining adhesion dependence of cells and a method for preventing or treating cancer, specifically metastatic cancer by regulating the expression of the factors. The present disclosure suggests a completely new inhibitory target for cancer metastasis, which allows remarkable blocking of the production of circulating tumor cells from primary cancer tissues and, ultimately, provision of an effective anticancer composition capable of significantly reducing the mortality rate of cancer.

Classes IPC  ?

• A61K 31/65 - Tétracyclines
• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
• G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique

Abrégé

The present specification provides a polyimide resin composition which exhibits excellent transparency and mechanical properties while being capable of repeated self-healing, by comprising a multi-component polyimide combination, and a film comprising same. The film according to the present disclosure exhibits self-healing properties that can self-heal damage, such as cracks or shape deformation, that occurs at room temperature, wherein the self-healing is repeated. Thus, the lifespan of the film can be extended and reuse thereof is possible. The present disclosure can be used as an adhesive or a coating agent in electrical and electronic materials, and the like, and for example, can be effectively used as a cover window for covering the surface of a mobile, a display, or the like.

Classes IPC  ?

• C08G 73/10 - PolyimidesPolyester-imidesPolyamide-imidesPolyamide-acides ou précurseurs similaires de polyimides
• C08L 79/08 - PolyimidesPolyester-imidesPolyamide-imidesPolyamide-acides ou précurseurs similaires de polyimides
• C08J 5/18 - Fabrication de bandes ou de feuilles

Abrégé

The present invention relates to a pharmaceutical composition for inhibiting cancer metastasis and, preferably, to a pharmaceutical composition for inhibiting invasion or metastasis by invasive colon cancer. The composition of the present invention, in invasive colon cancer especially that with a poor prognosis, is non-toxic to cancer cells and has the effect of only inhibiting invasion, and thus can minimize human toxicity, which can be an inevitable side effect of anticancer agents, and can effectively prevent only invasion or metastasis, which is fatal with respect to prognosis, and thus can extend the survival of cancer patients.

Classes IPC  ?

• A61K 31/50 - PyridazinesPyridazines hydrogénées
• A61K 31/497 - Pyrazines non condensées contenant d'autres hétérocycles
• A61K 31/4985 - Pyrazines ou pipérazines condensées en ortho ou en péri avec des systèmes hétérocycliques
• A61K 31/496 - Pipérazines non condensées contenant d'autres hétérocycles, p. ex. rifampine, thiothixène ou sparfloxacine
• A61K 31/506 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime non condensées et contenant d'autres hétérocycles
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
• A61P 35/00 - Agents anticancéreux
• A61P 35/04 - Agents anticancéreux spécifiques pour le traitement des métastases
• A23L 33/10 - Modification de la qualité nutritive des alimentsProduits diététiquesLeur préparation ou leur traitement en utilisant des additifs

Abrégé

The present invention relates to a human implant for inducing body vessel regeneration and a method of treating lymphedema or ischemic disease using same. A structure according to the present invention provides appropriate physical strength and mechanical support, and thus not only prevents body vessels, such as lymph vessels or blood vessels, from being re-damaged during regeneration, but also promotes the flow of body fluids through capillary action by using a simple rod structure having concave and convex portions (e.g., H-shaped steel) or lumens (e.g., tubular shape), thereby structurally and functionally mimicking in-vivo body vessel tissues. In addition, the structure of the present invention decomposes at an appropriate point in time after the completion of body vessel regeneration after being implanted in a lesion, and thus can be useful as an efficient treatment for various pathological conditions caused by blocked lymphatic fluid flow or reduced blood flow.

Classes IPC  ?

• A61L 27/18 - Matériaux macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone
• A61L 27/58 - Matériaux au moins partiellement résorbables par le corps

Abrégé

The present disclosure relates to a 5G or 6G communication system for supporting a higher data transmission rate beyond a 4G communication system such as LTE. The present disclosure provides a method for performing self-interference cancellation by a base station. The method of the present disclosure may comprise the steps of: acquiring adjacent resource block (RB)-related information for estimation of a self-interference (SI) coefficient; generating information on a reference signal pattern for each RB on the basis of the adjacent RB-related information; transmitting, to the terminal, information on the reference signal pattern for each RB; generating a downlink (DL) reference signal on the basis of the information on the reference signal pattern for each RB, and transmitting the DL reference signal to the terminal; receiving an SI signal associated with the DL reference signal; estimating the SI coefficient on the basis of the DL reference signal and the SI signal associated with the DL reference signal; and performing cancellation of the SI signal from a received UL signal on the basis of the SI coefficient.

Classes IPC  ?

• H04L 5/14 - Fonctionnement à double voie utilisant le même type de signal, c.-à-d. duplex
• H04L 5/00 - Dispositions destinées à permettre l'usage multiple de la voie de transmission
• H04L 25/02 - Systèmes à bande de base Détails
• H04W 72/04 - Affectation de ressources sans fil

Abrégé

The present invention relates to a non-invasive blood viscosity measurement method and system based on oxygen saturation and blood flow. The method and system for measuring blood viscosity in a non-invasive manner on the basis of oxygen saturation and blood flow is used to facilitate easy and rapid calculation of blood viscosity, thus enabling the immediate acquisition of blood viscosity data.

Classes IPC  ?

• A61B 5/02 - Détection, mesure ou enregistrement en vue de l'évaluation du système cardio-vasculaire, p. ex. mesure du pouls, du rythme cardiaque, de la pression sanguine ou du débit sanguin
• A61B 5/1455 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang en utilisant des capteurs optiques, p. ex. des oxymètres à photométrie spectrale
• A61B 5/145 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang
• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus

Abrégé

The disclosed embodiment provides an apparatus and method for measuring eye movement, that can accurately measure eye movement by determining the eye position at high speed and high resolution even with a low-cost camera by using a phase mask and rolling shutter method instead of a lens, and can perform early diagnosis of neurological diseases, etc. based on the measured eye movement.

Classes IPC  ?

• G06T 7/246 - Analyse du mouvement utilisant des procédés basés sur les caractéristiques, p. ex. le suivi des coins ou des segments
• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• A61B 5/16 - Dispositifs pour la psychotechnieTest des temps de réaction
• G06T 7/00 - Analyse d'image
• G06T 7/73 - Détermination de la position ou de l'orientation des objets ou des caméras utilisant des procédés basés sur les caractéristiques
• H04N 23/56 - Caméras ou modules de caméras comprenant des capteurs d'images électroniquesLeur commande munis de moyens d'éclairage
• H04N 25/531 - Commande du temps d'intégration en commandant des obturateurs déroulants dans un capteur SSIS CMOS
• A61B 3/14 - Dispositions spécialement adaptées à la photographie de l'œil

Abrégé

Provided are perovskite quantum dots showing an independent photoreaction to light stimulation in different wavelength bands from each other, a method for preparing the perovskite quantum dots, and an anti-counterfeiting ink including the perovskite quantum dots.

Classes IPC  ?

• C09K 11/77 - Substances luminescentes, p. ex. électroluminescentes, chimiluminescentes contenant des substances inorganiques luminescentes contenant des métaux des terres rares
• C09K 11/61 - Substances luminescentes, p. ex. électroluminescentes, chimiluminescentes contenant des substances inorganiques luminescentes contenant du fluor, du chlore, du brome, de l'iode ou des halogènes non spécifiés
• C09K 11/66 - Substances luminescentes, p. ex. électroluminescentes, chimiluminescentes contenant des substances inorganiques luminescentes contenant du germanium, de l'étain ou du plomb

Abrégé

A composition according to the present invention, when used alone, is capable of inhibiting the growth of anticancer drug-resistant cancer by overcoming anticancer drug resistance or enhancing anticancer drug sensitivity, and when co-administered with an anticancer drug, may be used very effectively for the prevention, alleviation or treatment of various cancers, especially anticancer drug-resistant cancer.

Classes IPC  ?

• A61K 31/4525 - Pipéridines non condensées, p. ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un cycle à cinq chaînons avec l'oxygène comme hétéro-atome du cycle
• A61K 31/282 - Composés du platine
• A61K 31/4545 - Pipéridines non condensées, p. ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un cycle à six chaînons avec l'azote comme hétéro-atome du cycle, p. ex. pipampérone, anabasine
• A61K 33/243 - PlatineSes composés
• A61P 35/00 - Agents anticancéreux
• G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique

Abrégé

The present invention relates to GPCR ligand collagen peptides produced through microbial fermentation, and in particular, to a method of preparing collagen peptides obtained by culturing a microorganism, peptides prepared by the method, and a composition including the peptide as an active ingredient; and a composition for improving intestinal function, relieving inflammation, and/or promoting wound healing, and a method of preparing the composition.

Classes IPC  ?

• A61K 38/39 - Peptides du tissu connectif, p. ex. collagène, élastine, laminine, fibronectine, vitronectine, globuline insoluble à froid [CIG]
• A61P 17/02 - Médicaments pour le traitement des troubles dermatologiques pour traiter les blessures, les ulcères, les brûlures, les cicatrices, les cheloïdes, ou similaires
• A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]

Abrégé

Provided is a biphasic electrolyte solution including: an aqueous electrolyte solution layer including a kosmotropic metal salt and water; and a nonaqueous electrolyte solution layer including a second metal salt and a nonaqueous organic solvent, and the biphasic electrolyte solution may provide a battery which satisfies both excellent battery performance and life characteristics.

Classes IPC  ?

• H01M 10/0567 - Matériaux liquides caracterisés par les additifs
• H01M 10/052 - Accumulateurs au lithium
• H01M 10/0568 - Matériaux liquides caracterisés par les solutés
• H01M 10/0569 - Matériaux liquides caracterisés par les solvants

Abrégé

An electronic device may include: a first temperature sensor configured to measure a first temperature of a skin surface when a user comes into contact with a main body of the electronic device; a first heating element spaced apart from the first temperature sensor by a first predetermined distance; a second temperature sensor spaced apart from the first heating element by a second predetermined distance and configured to measure a second temperature inside the main body; and a processor configured to: estimate heat flux based on the first temperature and the second temperature; estimate a blood perfusion rate of the user based on a temperature of the first heating element and the first temperature, and estimate a core body temperature of a user based on the first temperature, the estimated heat flux, and the estimated blood perfusion rate.

Classes IPC  ?

• A61B 5/01 - Mesure de la température de parties du corps
• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus

Abrégé

The present specification provides a method for predicting the prognosis of endometrial cancer and a kit using same, the method comprising the steps of: detecting whether MSH2 or MSH6 is deficient in a biological sample isolated from an endometrial cancer patient; measuring a nectin-4 expression rate in the biological sample isolated from an endometrial cancer patient; and predicting an endometrial cancer prognosis of the endometrial cancer patient on the basis of the detected MSH2 or MSH6 deficiency and the measured nectin-4 expression rate. According to the present invention, when the nectin-4 expression rate is 3% or more in an MSH2- or MSH6-deficient patient group, there is the effect of predicting that the prognosis of endometrial cancer is poor.

Classes IPC  ?

• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
• G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer

Abrégé

A semiconductor memory device including a semiconductor layer including a source area, a channel area, and a drain area arranged in a first horizontal direction on a substrate, a cell capacitor extending in the first horizontal direction on the substrate and including a lower electrode layer, a capacitor dielectric film, and an upper electrode layer connected to the source area, a bit line extending in a vertical direction on the substrate and connected to the drain area, and a gate structure covering the channel area, and the gate structure including a gate dielectric film on the channel area and a gate electrode film on the gate dielectric film, wherein in the vertical direction, a first thickness of an end of the channel area facing the source area is greater than a second thickness of another end of the channel area facing the drain area may be provided.

Classes IPC  ?

• H10B 12/00 - Mémoires dynamiques à accès aléatoire [DRAM]

Abrégé

Provided in the present specification are a method for diagnosing endometrial cancer using a nectin-4 expression rate, and a kit using same, the method comprising the steps of: measuring a nectin-4 expression rate in a biological sample isolated from an individual; and determining, on the basis of the measured nectin-4 expression rate, whether the individual has endometrial cancer. The present invention has the effect of providing a novel biomarker for the diagnosis, prediction, and evaluation of endometrial cancer.

Classes IPC  ?

• G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer
• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer

Abrégé

The present invention relates to a method for predicting the response to immunotherapeutic agents, comprising a step of measuring, in cancer cells or cancer tissue, the expression level of a dexamethasone-induced ras-related protein 1 (Dexras 1) gene or a protein encoded thereby. According to the present invention, research has been carried for prediction of the response to immunotherapeutic agents and, particularly, research has been carried out for prediction of the response to immunotherapeutic agents, highly reliable therapeutic agents and effective diagnosis of stem cell-like gastric cancer, which has the poorest prognosis and for which discovery of an effective treatment and diagnosis is difficult. As a result, it has been identified that in refractory carcinoma, the expression of Dexras 1 is high and, when an immunotherapeutic agent is injected, resistance to the immunotherapeutic agent is exhibited. In addition, changes in the expression level of Dexras 1 in cancer samples are measured such that immunotherapeutic agents for refractory cancer, such as stem cell-like gastric cancer that is difficult to be treated, are provided and refractory cancer can be diagnosed, and the response to anticancer immunotherapeutic agents for effective immunotherapy can be predicted such that the present invention has been completed. Therefore, the present invention is expected to be widely used in the development of novel therapeutic agents for refractory cancer.

Classes IPC  ?

• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
• G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer
• A01K 67/027 - Nouvelles races ou races modifiées de vertébrés
• C12N 15/85 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules animales