The present invention provides a method for determining whether a mature cotton fiber includes Giza 94 (G94) variety of G. barbadense. The method comprises providing a mature cotton fiber from a manufactured article; extracting DNA from the mature cotton fiber; amplifying a portion of said DNA with a PCR-based technique using a primer set comprising SEQ ID NO: 1 and SEQ ID NO: 2, thereby producing one or more amplicons, generating a variable amplicon length polymorphism profile (VALP) from the amplicons, and comparing the generated VALP with a G94 variable amplicon length polymorphism profile, thereby determining whether the mature cotton fiber incudes G94.
C12Q 1/6895 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les plantes, les champignons ou les algues
3.
Methods and Systems of Producing Single Stranded DNA via PCR Using Biotin-Labeled Primers
The present invention provides methods of producing single-stranded DNA (ssDNA) from a double-stranded DNA (dsDNA) template. The method includes selecting either the (+)-strand or the (−)-strand of a dsDNA template as a target ssDNA, wherein if the target ssDNA is the (+)-strand of the dsDNA template, a biotin label is added onto the reverse primer, and wherein if the target ssDNA is the (−)-strand of the dsDNA template, a biotin label is added onto the forward primer. Next PCR is performed to produce biotinylated dsDNA fragments. Once the PCR is terminated, the biotinylated dsDNA fragments are purified. Next the target ssDNA is separated from the biotinylated dsDNA by immobilizing the biotinylated dsDNA onto a surface and precipitating the target ssDNA.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
mRNA production platform and in vivo transcription, namely, biochemicals for in vitro and in vivo scientific use; Biological preparations for use in industry and science; nucleic acid for laboratory use Nucleic acid sequences for medical purposes; nucleic acid sequences and chemical reagents for medical and veterinary purposes; Biological preparations for the treatment of cancer Custom manufacturing of DNA expression vectors, namely plasmids, viruses and biological constructs designed for gene expression in cells, for others; custom biological manufacturing services for others, namely, manufacturing of pharmaceuticals using biological organisms in the manufacturing process, namely, nucleic acids, DNA, RNA, and mRNA; custom manufacture of pharmaceuticals using biological organisms in the manufacturing process, namely, DNA and mRNA for others as components of in vitro diagnostic tests and for preclinical nucleic acid-based drug development in the fields of adoptive cell therapies as CAR T and TCR T therapies, anti-viral and cancer DNA vaccines, RNA therapies, clustered regularly interspaced short palindromic repeats (CRISPR) based therapies, and gene therapies Scientific research; biotechnology research and development; biological research; biomedical research; research and development services in the field of DNA based medications and therapies; DNA expression vector design and development for others; biotech and clinical research and development of DNA based medications and therapies
5.
SYSTEM AND METHOD FOR ON-SITE AUTHENTICATION OF NUCLEIC ACID TAGGANTS USING NUCLEIC ACID LATERAL FLOW DEVICE
A system and method for interrogating objects containing a nucleic acid taggant including a sample collection device for obtaining a sample containing a nucleic acid taggant from an object. The at least one taggent includes at least one predetermined nucleic acid sequence. A reagent contacts the sample. A polymerase chain reaction (PCR) device for device for receiving the sample and amplifying the at least one nucleic acid sequence contained in the sample to produce a PCR sample solution. A Nucleic Acid Lateral Flow (NALF) device has a sample receiving end for receiving the PCR sample solution and having an indication end. The indication end includes a first test area and at least one control area. The first test area provides a visual indication upon the detection of a first predetermined nucleic acid sequence carried in the PCR sample solution.
The present invention provides a method for determining whether a mature cotton fiber includes Giza 94 (G94) variety of G. barbadense. The method comprises providing a mature cotton fiber from a manufactured article; extracting DNA from the mature cotton fiber; amplifying a portion of said DNA with a PCR-based technique using a primer set comprising SEQ ID NO: 1 and SEQ ID NO: 2, thereby producing one or more amplicons, generating a variable amplicon length polymorphism profile (VALP) from the amplicons, and comparing the generated VALP with a G94 variable amplicon length polymorphism profile, thereby determining whether the mature cotton fiber incudes G94.
C12Q 1/6895 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les plantes, les champignons ou les algues
C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p. ex. pour test de réaction en chaîne par polymérase [PCR]
C07H 21/04 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p. ex. acides nucléiques avec le désoxyribosyle comme radical saccharide
7.
METHODS FOR GENETIC ANALYSIS OF TEXTILES COMPRISING G. BARBADENSE
The present invention provides a method for determining whether a mature cotton fiber includes Giza 94 (G94) variety of G. barbadense. The method comprises providing a mature cotton fiber from a manufactured article; extracting DNA from the mature cotton fiber; amplifying a portion of said DNA with a PCR-based technique using a primer set comprising SEQ ID NO: 1 and SEQ ID NO: 2, thereby producing one or more amplicons, generating a variable amplicon length polymorphism profile (VALP) from the amplicons, and comparing the generated VALP with a G94 variable amplicon length polymorphism profile, thereby determining whether the mature cotton fiber incudes G94.
C12Q 1/6895 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les plantes, les champignons ou les algues
C07H 21/04 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p. ex. acides nucléiques avec le désoxyribosyle comme radical saccharide
C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p. ex. pour test de réaction en chaîne par polymérase [PCR]
The present invention relates generally to PCR-based in vitro diagnostics and methods of treatment for SARS-CoV-2, the virus that causes COVID- 19, and more specifically, to compositions and methods for the detection of wildtype and variants of SARS-CoV-2 in a patient specimen and methods of treating SARS-CoV-2 based on said detection.
C12Q 1/6827 - Tests d’hybridation pour la détection de mutation ou de polymorphisme
C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
A61P 31/14 - Antiviraux pour le traitement des virus ARN
C12Q 1/686 - Réaction en chaine par polymérase [PCR]
05 - Produits pharmaceutiques, vétérinaires et hygièniques
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Medical diagnostic assays for testing for Covid-19/SARS-CoV-2; Medical diagmostic assays for testing for viruses Platform as a service (PaaS) featuring computer software platforms to review and analyze COVID-19/ SARS-CoV-2 medical diagnostic surveillance testing results and to track, manage, and analyze data related to employee, customer, and passenger health status Medical diagmostic testing, namely, Covid-19/SARS-CoV-2 Surveillance testing; viral surveillance testing; Medical diagmostic testing consulting services in the fields of COVID-19/SARS-CoV-2 surveillance testing; Medical diagmostic testing consulting services in the fields of viral surveillance testing
Methods for marking cellulosic products, including cellulosic fibers such as lyocell and cellulosic films, including methods for marking such products with a detectable nucleic acid marker to identify and validate the origin or authenticity of the products or items manufactured using such products. Detectably-marked cellulosic products marked with nucleic acid markers for authentication, validation and tracking are also provided.
D21H 21/44 - Éléments de sécurité latents, c.-à-d. pouvant être détectés ou devenant apparents uniquement par utilisation de méthodes ou de dispositifs particuliers de vérification ou d'altération
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
D01F 2/08 - Composition de la solution ou du bain de filage
D21H 13/08 - Fibres cellulosiques synthétiques à partir de cellulose régénérée
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
DNA analysis services for product authentication and
validation of source; product authentication services using
DNA analysis for verifying and validating the source of a
wide variety of industrial, textile, consumer and military
goods in wholesale and retail supply chains by using
embedded or coated biologics and taggants; DNA analysis
services for source authentication of textiles in the retail
supply chain.
Towels, beach towels, bath towels, all of the aforementioned goods treated with a molecular and/or biologic taggant for product tracking, authentication and/or validation of source
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
DNA analysis services for product authentication and validation of source; product authentication services using DNA analysis for verifying and validating the source of a wide variety of industrial, textile, consumer and military goods in wholesale and retail supply chains by using embedded or coated biologics and taggants; DNA analysis services for source authentication of textiles in the retail supply chain.
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
DNA analysis services for product authentication and validation of source; product authentication services using DNA analysis for verifying and validating the source of a wide variety of industrial, textile, consumer and military goods in wholesale and retail supply chains by using embedded or coated biologics and taggants; DNA analysis services for source authentication of textiles in the retail supply chain
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
DNA analysis services for product authentication and product source verification; product authentication services using DNA analysis for the purpose of verifying the source of a wide variety of industrial, textile, consumer and military goods in wholesale and retail supply chains using embedded or coated biologics and/or taggants; DNA analysis services for the authentication of textiles, pharmaceutical packaging and pharmaceutical tablets or capsules; DNA forensic analysis services
09 - Appareils et instruments scientifiques et électriques
Produits et services
Biologically encoded liquid taggants for use in passive labeling and tracing of objects for the purpose of linking marked objects to its owner; biologically encoded liquid marking taggants for the purpose of linking marked objects to its owner; biologically encoded marking inks incorporating nucleic acids for tagging and identifying objects and linking them to its owner; kit comprising a biologically encoded liquid marking substance and a unique DNA identifier for the purpose of linking marked objects to its owner; biologically encoded liquid taggants for application to coatings in the nature of paints for use in source identification of marked objects
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Biologics in the nature of nucleic acids and proteins for addition to polymers used in manufacturing of consumer, military and industrial goods and products for authentication, tracking and tracing such goods and products. Laboratory services, namely, authentication for the purposes of validation, tracking and tracing of goods and products as they move through the stream of commerce from initial shipment to delivery, based on embedded or coated biologics on a wide variety of industrial, consumer and military goods and products.
18.
ALKALINE ACTIVATION FOR IMMOBILIZATION OF DNA TAGGANTS
The invention provides methods for stably binding and immobilizing deoxyribonucleic acid onto objects and substrates. The method includes exposing the deoxyribonucleic acid to alkaline conditions, and contacting the deoxyribonucleic acid to the object or substrate. The alkaline conditions are produced by mixing the deoxyribonucleic acid with an alkaline solution having a pH of about 9.0 or higher, and contacting the deoxyribonucleic acid to the substrate. The immobilized DNA can be used as a taggant and can be used in combination with other detectable taggants, such as optical reporters. Methods for authentication of a DNA marked object are also provided.
C07H 21/04 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p. ex. acides nucléiques avec le désoxyribosyle comme radical saccharide
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
Methods for incorporating and/or immobilizing security markers by exposure to an electromagnetic pulse, such as for instance a LASER pulse, to produce a marked object that can be authenticated only by using proprietary biological, chemical or physical analysis, the method includes: exposing a surface of the object to be marked to an electromagnetic pulse to activate the surface or a coating on the surface, and exposing the surface to a detectable marker molecule and thereby immobilizing the detectable marker molecule, such as a biological marker molecule, e.g. DNA on the surface of the object. The method of marking the object may include exposing a photo-polymerizable monomer on at least a portion of the surface of an object to be marked to a LASER pulse to initiate a reaction to cross link the photo-polymerizable monomer binding, trapping or encapsulating a detectable marker on the surface of the object.
C12Q 1/00 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions
B01J 13/18 - Polymérisation in situ où tous les réactifs sont présents dans la même phase
20.
DNA MARKING OF PREVIOUSLY UNDISTINGUISHED ITEMS FOR TRACEABILITY
The invention provides a method of marking an item with a DNA marker for authenticating or tracking, wherein the method includes providing an item for marking; and affixing to the item, or embedding into the item a medium comprising a DNA marker; wherein the DNA marker encodes information unique to said item. The affixing can be by printing, molding, varnishing, stamping, painting, writing, coating or by labeling.
A method of marking an inventory item includes providing an activatable smoke generator and a reservoir for holding a smoke fluid and adapted to provide a flow of smoke fluid to the generator. The reservoir contains a smoke fluid including a carrier nucleic acid having a uniquely identifiable sequence, and upon activation of the smoke generator, marker smoke is generated and targeted to flow over the inventory item. The method further includes activating the smoke generator to produce the marker smoke including the carrier nucleic acid so as to cause the marker smoke to flow over the inventory item and thereby to detectably mark the inventory item with carrier nucleic acid.
G08B 15/02 - Identification, mise en alarme ou mise hors d'état de nuire des cambrioleurs, des voleurs ou autres intrus, p. ex. en employant des explosifs avec de la fumée, du gaz, ou de la poudre, ou un liquide coloré ou parfumé
22.
SECURITY SYSTEM AND METHOD OF MARKING AN INVENTORY ITEM AND/OR PERSON IN THE VICINITY
A method of marking an inventory item includes providing an activatable smoke generator and a reservoir for holding a smoke fluid and adapted to provide a flow of smoke fluid to the generator. The reservoir contains a smoke fluid including a carrier nucleic acid having a uniquely identifiable sequence, and upon activation of the smoke generator, marker smoke is generated and targeted to flow over the inventory item. The method further includes activating the smoke generator to produce the marker smoke including the carrier nucleic acid so as to cause the marker smoke to flow over the inventory item and thereby to detectably mark the inventory item with carrier nucleic acid.
G08B 15/02 - Identification, mise en alarme ou mise hors d'état de nuire des cambrioleurs, des voleurs ou autres intrus, p. ex. en employant des explosifs avec de la fumée, du gaz, ou de la poudre, ou un liquide coloré ou parfumé
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
23.
USE OF PERTURBANTS TO FACILITATE INCORPORATION AND RECOVERY OF TAGGANTS FROM POLYMERIZED COATINGS
The invention provides methods for increasing the recoverability of taggants from an object. The methods include the steps of incorporating a taggant into a solution; mixing the solution including the taggant with a perturbant to form a first perturbant taggant solution; mixing the first perturbant taggant solution with a polymer to form a second perturbant taggant polymer solution; and applying the second perturbant taggant polymer solution to at least a portion of the object to form a taggant-coated object. Methods for authentication of a taggant marked object are also provided.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
G09F 3/00 - Étiquettes, fiches ou moyens analogues d'identification ou d'indicationSceauxTimbres-poste ou timbres analogues
24.
Method for a continuous rapid thermal cycle system
Disclosed herein is an efficient, high speed production scale synthesis method for high molecular weight organic substances, such as DNA. The invention includes a method of conducting a polymerase chain reaction which comprises transporting a liquid through polymeric tubing disposed through a first reaction cycle region and at least a second reaction cycle region, each of which regions comprises at least a first and a second temperature zone, the temperature in each zone of said at least second region being substantially identical to the corresponding first and second zones in said first region, wherein said liquid is an aqueous solution comprising polymerase chain reaction reactants and a surface absorbing polymer.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
C12P 19/34 - Polynucléotides, p. ex. acides nucléiques, oligoribonucléotides
25.
METHODS FOR GENETIC ANALYSIS OF TEXTILES MADE OF GOSSYPIUM BARBADENSE AND GOSSYPIUM HIRSUTUM COTTON
Methods for distinguishing between cotton species by analyzing a sample of mature cotton fibers from raw cotton materials or from textile goods are disclosed. DNA is extracted from the mature cotton fiber sample and subjected to PCR techniques which enable the identification of the species of cotton utilized in the textile or cotton material of interest.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
C12P 19/34 - Polynucléotides, p. ex. acides nucléiques, oligoribonucléotides
26.
METHODS FOR GENOTYPING MATURE COTTON FIBERS AND TEXTILES
Methods for distinguishing between cotton cultivars of a specific species by analyzing a sample of mature cotton fibers from raw cotton materials or from textile goods are disclosed. DNA is extracted from the mature cotton fiber sample and subjected to PCR techniques which enable the identification of the cultivar of a particular cotton species utilized in the textile or cotton material of interest.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
C12P 19/34 - Polynucléotides, p. ex. acides nucléiques, oligoribonucléotides
27.
METHOD FOR A CONTINUOUS RAPID THERMAL CYCLE SYSTEM
An efficient, high speed production scale synthesis method for high molecular weight organic substances such as DNA by methods which require multiple temperature environments. In a Polymerase Chain Reaction operation, a substantially ho-mogeneous liquid of the reactants is conveyed by tubing through a minimum of two temperature zones in the presence of a sufficient amount of a surface absorbing polymer to both condition the tubing and protect the catalyzing enzyme so as to increase production, efficiency and minimize down time needed to regenerate the system for further use. In particular, a block copolymer of ethylene oxide and propylene oxide is used.
09 - Appareils et instruments scientifiques et électriques
13 - Armes à feu; explosifs
45 - Services juridiques; services de sécurité; services personnels pour individus
Produits et services
Security products for protection against assault, and intrusion; security control apparatus and instruments; security monitoring apparatus for the detection of intruders; security devices for premises; personal security apparatus including personal alarms; security marking equipment. Apparatus for personal defence and for defending premises, including devices for marking attackers and intruders. Advisory services relating to the security of premises and of personal security; advisory services relating to security; provision of security monitoring services; security services for buildings; forensic services for criminal investigations.
09 - Appareils et instruments scientifiques et électriques
13 - Armes à feu; explosifs
45 - Services juridiques; services de sécurité; services personnels pour individus
Produits et services
Security products for protection against assault, and intrusion; security control apparatus and instruments; security monitoring apparatus for the detection of intruders; security devices for premises; personal security apparatus including personal alarms; security marking equipment. Apparatus for personal defence and for defending premises, including devices for marking attackers and intruders. Advisory services relating to the security of premises and of personal security; advisory services relating to security; provision of security monitoring services; security services for buildings; forensic services for criminal investigations.
30.
SYSTEM AND METHOD FOR AUTHENTICATING MULTIPLE COMPONENTS ASSOCIATED WITH A PARTICULAR PRODUCT
A method for authenticating a product where the product is composed of a plurality of components is described. The method for authenticating the product comprises providing a liquid compound, e.g. paint, that comprises at least one invisible market, e.g. nucleic acid, in which the compound is associated with a first entity. The method then proceeds to apply the compound to the surface of the product at the juncture of at least two components. The method also comprises associating the application of the compound to the at least two components with the first entity.
