The present invention relates to the use of botulinum toxin for the treatment of hyperpigmentation conditions. The use comprises the intradermal injection of botulinum toxin in the skin of a patient affected with the hyperpigmentation condition at a specified depth, volume and dose, thereby specifically targeting the epidermal and upper dermal layers. For example, the intradermal injection of botulinum toxin according to the present invention may be used in the treatment of melasma.
A61K 8/99 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des produits de constitution indéterminée ou leurs dérivés à base de micro-organismes autres que des algues ou des champignons, p.ex. à base de protozoaires ou de bactéries
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61Q 19/02 - Préparations pour les soins de la peau pour décolorer ou blanchir la peau chimiquement
2.
CROSS-LINKING POLYSACCHARIDE WITH FIBROIN AND USES OF THE OBTAINED MATERIAL
The invention proposes a method for preparing a cross-linked material, comprising forming amide bonds that conjugate one or more fibroin moieties with one or more polysaccharide moieties. The invention further relates to a cross-linked material obtainable from such method and to an injectable composition comprising the obtained cross-linked material. The cross-linked material can be a hydrogel and/or a super-volumizer and can be used in cosmetic and pharmaceutical applications.
The present invention relates to a dermal filler composition based on crosslinked hyaluronic acid, wherein the hyaluronic acid is crosslinked with a high molecular weight polyethylene glycol diglycidyl ether (PEGDE) crosslinker having an average number of —CH2—CH2—O— repetitive units of 8 to 90. Furthermore, the present invention relates to a method for preparing said dermal filler composition and its use for cosmetic purposes.
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Ultrasonic imaging apparatus, not for medical purposes;
computer hardware for visualizing tissue in the fields of
aesthetics and dermatology; downloadable fact sheets in the
field of aesthetics and dermatology; downloadable medical
software for visualizing tissue in the fields of aesthetics
and dermatology; recorded medical software for visualizing
tissue in the fields of aesthetics and dermatology; user
interfaces, namely touchscreens for electrotechnical and
electronic devices. Devices, apparatus and instruments for aesthetic tissue
treatment; aesthetic tissue treatment apparatus using
ultrasound; cosmetic apparatus using ultrasound for
performing aesthetic tissue treatment procedures; medical
instruments and apparatus; medical ultrasound instruments
and apparatus; medical instruments and apparatus for use in
treating dermatological disorders; medical devices for
non-surgical cosmetic treatments; ultrasonic imaging
apparatus for medical purposes; medical imaging apparatus. Aesthetician services; cosmetic treatment; cosmetic skin
care and tissue treatment services; non-invasive cosmetic
ultrasound procedures, namely for skin tightening, skin
firming, skin sculpting, and skin lifting; providing
information about health and wellness, namely, aesthetics
and dermatology; medical and cosmetic ultrasound imaging
services; medical services; medical skin care services;
medical services, namely ultrasound treatment; medical
services, namely dermatological treatment; non-invasive
medical ultrasound procedures, namely for skin tightening,
skin firming, skin sculpting, and skin lifting; providing
medical information in the field of medical skin care
services; providing medical advice in the field of medical
ultrasound imaging services.
5.
A ROCKING SHAKER FOR TREATING AT LEAST ONE FLUID SAMPLE
A rocking shaker (110) for treating at least one fluid sample is disclosed. The rocking shaker (110) comprises: i. at least one mechanical frame (112), the mechanical frame (112) comprising at least one tilting axle (114); ii. at least one mounting platform (128) being tiltably mounted on the tilting axle (114), the mounting platform (128) being configured for receiving at least one sample holder; iii. at least one actuator (136), the actuator (136) being configured for periodically tilting the mounting platform (128) about the tilting axle (114) over an angular orientation range; and iv. at least one driving circuit (220) for electrically driving the actuator (136), the driving circuit (220) comprising at least one switch-off device (222), the switch-off device (222) being configured for automatically bringing the mounting platform (128) in a predetermined switch-off orientation when the rocking shaker (110) is switched off.
The invention pertains to a method for directly determining the biological activity of a Neurotoxin polypeptide in cells, comprising the steps of: a) incubating cells susceptible to Neurotoxin intoxication with a Neurotoxin polypeptide for a time and under conditions which allow for the Neurotoxin polypeptide to exert its biological activity; b) fixing the cells and, optionally, permeabilizing the cells with a detergent; c) contacting the cells with at least a first capture antibody specifically binding to the non-cleaved and Neurotoxin-cleaved substrate and with at least a second capture antibody specifically binding to the cleavage site of the Neurotoxin-cleaved substrate, under conditions which allow for binding of the capture antibodies to the substrates; d) contacting the cells with at least a first detection antibody specifically binding to the first capture antibody, under conditions which allow for binding of the first detection antibody to the first capture antibody, thus forming first detection complexes, and at least a second detection antibody specifically binding to the second capture antibody, under conditions which allow for binding of the second detection antibody to the second capture antibody, thus forming second detection complexes; e) determining the amount of the first and second detection complexes of step d), and f) calculating the amount of substrate cleaved by the Neurotoxin polypeptide in the cells by means of the second detection complexes, thereby determining the biological activity of the Neurotoxin polypeptide in the cells. The invention further provides for a kit for carrying out the method of the invention.
G01N 33/50 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique
The present invention concerns a composition comprising (a) botulinum toxin and (b) non-crosslinked hyaluronic acid and its use of the treatment or prevention of dystonia, spasticity and/or wrinkles. Further, the present invention relates to a method for cosmetically smoothing or preventing wrinkles comprising the step of administering the present composition.
The present invention relates to a syringe barrel having an interior surface coated with a silicone film having a thickness in the range of 5 nm to 100 nm. It further relates to a method for manufacturing said syringe barrel comprising the step of reducing an initial thickness of a pre-formed silicone film on the interior surface of a syringe barrel to a thickness within the range of about 5 nm to about 100 nm by exposing the syringe barrel to an organic solvent or by subjecting the syringe barrel to mechanical treatment. Furthermore, the present invention relates to a syringe comprising the syringe barrel of the invention, a kit comprising said syringe, and cosmetic and therapeutic uses of said syringe.
A61M 5/315 - Pistons; Tiges de piston; Guidage, blocage, ou limitation des mouvements de la tige; Accessoires disposés sur la tige pour faciliter le dosage
10.
INJECTABLE GEL COMPRISING BOTULINUM TOXIN AND USES THEREOF
The present invention relates to a composition comprising (A) a cross-linked material comprising one or more fibroin moieties and one or more polysaccharide moieties covalently conjugated with each other, (B) botulinum toxin. Furthermore, the present invention relates to therapeutic and aesthetic uses of such composition.
The present invention generally relates to the use of botulinum toxin for lower face and neck rejuvenation by injection of highly concentrated botulinum toxin into platysma, more specifically into platysma bands and the platysma muscle at the jawline. Specifically, the botulinum toxin is injected in the platysma bands and the platysma muscle at the jawline at a dose of 3 U to 5 U and a volume of 0.04 ml to 0.06 ml per injection point. Furthermore, the present invention relates to a method for lower face and neck rejuvenation comprising injection of botulinum toxin in platysma bands and in the platysma muscle at the jawline at a dose of 3 U to 5 U and a volume of 0.04 ml to 0.06 ml per injection point.
The present invention generally relates to the use of botulinum toxin for neck rejuvenation by injection of highly concentrated botulinum toxin into the platysma muscle. Specifically, the botulinum toxin is injected in at least one platysma band of a subject at a concentration of more than 100 U/ml. Furthermore, the present invention relates to a method for neck rejuvenation involving injection of botulinum toxin at high concentration.
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Ultrasonic imaging apparatus, not for medical purposes; Computer hardware for visualizing tissue in the fields of aesthetics and dermatology; downloadable fact sheets in the field of aesthetics and dermatology; downloadable medical software for visualizing tissue in the fields of aesthetics and dermatology; recorded medical software for visualizing tissue in the fields of aesthetics and dermatology; user interfaces, namely touchscreens for electrotechnical and electronic devices. Devices, apparatus and instruments for aesthetic tissue treatment; Aesthetic tissue treatment apparatus using ultrasound; Cosmetic apparatus using ultrasound for performing aesthetic tissue treatment procedures; Medical instruments and apparatus; Medical ultrasound instruments and apparatus; Medical instruments and apparatus for use in treating dermatological disorders; Medical devices for non-surgical cosmetic treatments; Ultrasonic imaging apparatus for medical purposes; Medical imaging apparatus. Aesthetician services; Cosmetic treatment; Cosmetic skin care and tissue treatment services; Non-invasive cosmetic ultrasound procedures, namely for skin tightening, skin firming, skin sculpting, and skin lifting; Providing information about health and wellness, namely, aesthetics and dermatology; Medical and cosmetic ultrasound imaging services; Medical services; Medical skin care services; Medical services, namely ultrasound treatment; Medical services, namely dermatological treatment; Non-invasive medical ultrasound procedures, namely for skin tightening, skin firming, skin sculpting, and skin lifting; Providing medical information in the field of medical skin care services; Providing medical advice in the field of medical ultrasound imaging services.
Shaving apparatus, electric and non-electric; depilation
appliances, electric and non-electric. Heating appartus for waxing and depilation; heating
apparatus for warming wax, and spatulas with integrated
heating apparatus for applying wax to the skin.
17.
HIGH DOSE AND LOW VOLUME BOTULINUM TOXIN TREATMENT OF FACIAL WRINKLES
The present invention relates the use of botulinum toxin for the treatment of facial wrinkles, wherein botulinum toxin is administered at high doses (e.g., 50 U to 200 U) using small injection volumes (e.g., 0.05 ml to 0.35 ml). Furthermore, the present invention relates to a method for the treatment of facial wrinkles (e.g., glabellar frown lines) by injecting small volumes of a highly concentrated botulinum toxin solution into a target facial area of a subject.
The present invention relates to a plunger (20) and a finger grip (30) for a syringe assembly (100), methods for manufacturing them, to a syringe assembly (100), to a kit comprising parts of a syringe assembly (100), and to the use of a syringe assembly (100) or of a kit, wherein the syringe assembly (100) comprises a syringe barrel (10), a finger grip (30) having flanges (31, 32), and a plunger (20) having a plunger rod (21) and a plunger head (22). The plunger (20) comprises a grip pad (23) made by injection molding and attached to a proximal facing surface (24) of the plunger head. The finger grip (20) comprises a grip pad (35) also made by injection molding and attached to a distal facing surface of at least one flange (31, 32) of the finger grip (30).
A liquid composition for improving the facial contour and shape of the human or animal face by injection, the liquid composition comprising water and at least one of the following components A, B and C:
A liquid composition for improving the facial contour and shape of the human or animal face by injection, the liquid composition comprising water and at least one of the following components A, B and C:
at least one component A, which leads to an osmotic concentration in the range from 500 to 5000 mOsm in the liquid composition,
A liquid composition for improving the facial contour and shape of the human or animal face by injection, the liquid composition comprising water and at least one of the following components A, B and C:
at least one component A, which leads to an osmotic concentration in the range from 500 to 5000 mOsm in the liquid composition,
at least one high viscosity component B, which leads to a viscosity of the liquid composition in the range from 10 to 1500 mPas,
A liquid composition for improving the facial contour and shape of the human or animal face by injection, the liquid composition comprising water and at least one of the following components A, B and C:
at least one component A, which leads to an osmotic concentration in the range from 500 to 5000 mOsm in the liquid composition,
at least one high viscosity component B, which leads to a viscosity of the liquid composition in the range from 10 to 1500 mPas,
at least one micro-particles component C, comprising micro-particles with an average particle size not larger than 0.25 mm, preferably in the range of 0.001 mm to 0.25 mm, and optionally comprising
A liquid composition for improving the facial contour and shape of the human or animal face by injection, the liquid composition comprising water and at least one of the following components A, B and C:
at least one component A, which leads to an osmotic concentration in the range from 500 to 5000 mOsm in the liquid composition,
at least one high viscosity component B, which leads to a viscosity of the liquid composition in the range from 10 to 1500 mPas,
at least one micro-particles component C, comprising micro-particles with an average particle size not larger than 0.25 mm, preferably in the range of 0.001 mm to 0.25 mm, and optionally comprising
a local anesthetic compound D.
A61Q 19/08 - Préparations contre le vieillissement
A61K 8/96 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des produits de constitution indéterminée ou leurs dérivés
This invention relates to improved uses of botulinum neurotoxins in the treatment of sialorrhea or diseases or conditions relating to increased saliva production. In particular are botulinum neurotoxins disclosed which are administered into parotid and submandibular glands in a dose ratio between 1.45 to 1 and 1.7 to 1.
The present invention generally relates to the use of botulinum toxin for the reduction of skin pore size and/or sebum production using specific dosing regimens and injection schemes. Specifically, the botulinum toxin is administered by intradermal injection into the skin of a subject at a concentration of 11 U/ml to 19 U/ml and at a volume of 0.07 ml to 0.12 ml per injection point. Furthermore, the present invention relates to a method for the reduction of skin pore size and/or sebum production using said specific dosing regimens and injection schemes.
The present invention relates to a liquid formulation comprising (i) botulinum toxin, (ii) human serum albumin (HSA), and optionally (iii) a tonicity agent and/or (iv) a buffering agent. In one aspect, the liquid formulation is characterized by a very low iron ion concentration. In another aspect, liquid formulation is characterized by the absence or very low concentration of tryptophan and/or N-acetyl-tryptophan. According to the present invention, the liquid formulation can be prepared by a method comprising the steps of contacting human serum albumin with a chelating agent to obtain a mixture and removing the chelating agent from the mixture. Furthermore, the present invention relates to the use of the liquid formulation in the treatment of therapeutic indications and cosmetic conditions.
The present invention relates to a liquid botulinum toxin formulation comprising: (i) botulinum toxin, (ii) a stabilizing protein such as human serum albumin, (iii) a chelating agent (e.g., EDTA) or phosphate, and optionally (iv) a salt of calcium, magnesium or zinc, (v) a tonicity agent and/or (vi) a buffering agent. In addition, the present invention relates to the use of the liquid botulinum toxin formulation for therapeutic and cosmetic treatments.
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
On-line advertisements; provision of space on web-sites for
advertising goods and services; on-line advertising on a
computer network. Providing electronic publications; electronic text
publishing services; creation [writing] of educational
content for podcasts; electronic publication of texts and
printed matter, other than publicity texts, on the internet;
education services relating to pharmacy; medical education
services; training services for medical visitors; providing
online electronic publications, not downloadable, conducting
of instructional seminars; providing continuing medical
education courses; on-line publishing services; arranging
and conducting of conferences; arranging and conducting of
congresses; arrangement of conventions for educational
purposes; organisation of seminars; arranging and conducting
of colloquiums; arranging and conducting of workshops;
arranging, conducting and organisation of seminars;
arranging of lectures; creation [writing] of podcasts.
Administration of a customer loyalty program which provides discounts on dermatological and aesthetics goods or services; Arranging and conducting incentive reward programs to promote the sale of dermatological and aesthetics good or services
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
Online advertising; advertising; provision of an on-line
marketplace for buyers and sellers of goods and services;
on-line advertising on a computer network. Training in the area of pharmacy; training in the medical
field; vocational training and further education; vocational
training services; vocational training services for medical
personnel; vocational training services in the area of
cosmetics; provision of online publications; carrying out
further education seminars; providing electronic
publications [non-downloadable]; publication of printed
matter; publication of printed matter in the medical field;
providing non-downloadable online electronic publications;
providing on-line publications [non-downloadable];
organization of conferences for educational purposes;
publication of electronic publications, printed matter and
printed publications and providing non-downloadable online
publications; arranging, conducting and organization of
workshops; arranging, conducting and organization of
colloquiums; organization of congresses; organization of
seminars; education services, namely, conducting of
presentations; arranging, conducting and organization of
seminars; publication and provision of books; publication,
rental and leasing of printed matter; publication and
provision of non-downloadable online publications and
electronic publications; publication of magazines and
providing on-line non-downloadable magazines.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
41 - Éducation, divertissements, activités sportives et culturelles
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Pharmaceuticals; medical products; Medicines for human purposes; Pre-filled syringes for medical and pharmaceutical purposes; Pharmaceutical and medical preparations for dermatological purposes and Pharmaceutical skin care preparation and Medicated preparations for nourishing the skin; Injectable pharmaceuticals; Dermatological preparations, Pharmaceutical preparations and Medical preparations, for use in the following fields: Skin rejuvenation. publishing and issuing of scientific papers; Conducting of seminars and congresses, Congresses, Arranging of lecture colloquiums and Arranging of workshops; Training of doctors; all the aforesaid services featuring the following fields: Esthetics, beauty and medicine. Skin treatment services; Consultancy and information in relation to the following fields: Pharmaceutical and medical products; Consultancy and information, in relation to the following fields: Medical equipment and Medical instruments; Counselling services in relation to the following fields: Esthetics, Beauty and Medicine.
41 - Éducation, divertissements, activités sportives et culturelles
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Paper, cardboard; printed matter, namely, scientific
publications, periodical publications, and circulars,
pamphlets, handbooks, curriculum, information cards, and
photographs, namely, handbooks, exercise books, notebooks,
reference books, books; paper; writing stationery; all the
aforesaid goods in the field of aesthetics, beauty and
medicine. Advertising; promotion services; all the aforesaid services
in the fields of aesthetics, beauty and medicine. Publication and editing of scientific papers; conducting of
seminars, congresses, arranging of congresses, lecture
colloquiums and workshops; training courses for doctors; all
the aforesaid services in the fields of aesthetics, beauty
and medicine. Skin treatment services; consultancy and information
services relating to pharmaceutical and medical products;
consultancy and information services relating to medical
devices and instruments; consultations in the field of
aesthetics, beauty and medicine.
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
(1) Online advertising; advertising; provision of an on-line marketplace for buyers and sellers of goods and services; on-line advertising on a computer network.
(2) Training in the area of pharmacy; training in the medical field; vocational training and further education; vocational training services; vocational training services for medical personnel; vocational training services in the area of cosmetics; provision of online publications; carrying out further education seminars; providing electronic publications [non-downloadable]; publication of printed matter; publication of printed matter in the medical field; providing non-downloadable online electronic publications; providing on-line publications [non-downloadable]; organization of conferences for educational purposes; publication of electronic publications, printed matter and printed publications and providing non-downloadable online publications; arranging, conducting and organization of workshops; arranging, conducting and organization of colloquiums; organization of congresses; organization of seminars; education services, namely, conducting of presentations; arranging, conducting and organization of seminars; publication and provision of books; publication, rental and leasing of printed matter; publication and provision of non-downloadable online publications and electronic publications; publication of magazines and providing on-line non-downloadable magazines.
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
online advertising services; advertising services; provision of an on-line marketplace for buyers and sellers of goods and services; on-line advertising on a computer network training in the area of pharmacy; training in the medical field; vocational training and further vocational education in the field of aesthetics, beauty, and medicine; vocational training services in the field of aesthetics, beauty, and medicine; vocational training services for medical personnel in the field of aesthetics, beauty, and medicine; vocational training services in the area of cosmetics; provision of online non-downloadable publications in the nature of books, journals, scientific articles, magazines, brochures, pamphlets in the field of aesthetics, beauty and medicine; carrying out further continuing professional education seminars in the field of aesthetics, beauty, and medicine; providing electronic publications, non-downloadable, in the nature of books, journals, scientific articles, magazines, brochures, pamphlets in the field of aesthetics, beauty, and medicine; publication of printed matter; publication of printed matter in the medical field; providing non-downloadable online electronic publications in the nature of books, journals, scientific articles, magazines, brochures, pamphlets in the field of aesthetics, beauty, and medicine; providing on-line publications, non-downloadable, in the nature of books, journals, scientific articles, magazines, brochures, pamphlets in the field of aesthetics, beauty, and medicine; organization and conducting of conferences for educational purposes in the field of aesthetics, beauty, and medicine; publication of electronic publications, printed matter and printed publications and providing non-downloadable online publications in the nature of books, journals, scientific articles, magazines, brochures, pamphlets in the field of aesthetics, beauty, and medicine; arranging, conducting and organization of workshops in the field of aesthetics, beauty, and medicine; arranging, conducting and organization of colloquiums in the field of aesthetics, beauty, and medicine; organization of congresses in the field of aesthetics, beauty, and medicine; organization and conducting of seminars in the field of aesthetics, beauty, and medicine; education services, namely, conducting of presentations in the field of aesthetics, beauty, and medicine; arranging, conducting and organization of seminars in the field of aesthetics, beauty, and medicine; publication of books and provision of online non-downloadable e-books in the field of aesthetics, beauty, and medicine; publication, rental and leasing of printed matter in the nature of books; publication of printed matter and provision of non-downloadable online publications and electronic publications in the nature of books, journals, scientific articles, magazines, brochures, pamphlets in the field of aesthetics, beauty, and medicine; publication of magazines and providing on-line non-downloadable magazines in the field of aesthetics, beauty, and medicine
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Pharmaceutical preparations; pharmaceutical products for use
in the aesthetic field and the treatment of diseases;
medical preparations; medical products; medicine for human
purposes; pharmaceuticals; pre-filied syringes for medical
purposes (pharmaceuticals); nervines. Medical instruments and devices; hypodermic needles; medical
syringes; systems for injecting medical or pharmaceutical
fluids; one-dose injectable devices of medical or
pharmaceutical fluids; receptacles for applying medicine.
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
On-line advertisements by means of online advertising services; provision of space on web-sites for advertising goods and services; on-line advertising on a computer network Providing online non-downloadable electronic publications in the nature of brochures in the field of medicine and healthcare; electronic text publishing services, namely, publication of text and graphic works of others on the internet featuring information on medicine and healthcare; creation, namely scriptwriting of educational content for podcasts for non-advertising purposes; electronic publication of texts and printed matter, other than publicity texts, on the internet, namely, publication of text and graphic works of others on the internet featuring information on medicine and healthcare; education services, namely, providing continuing professional education courses relating to pharmacy; providing medical education services in the nature of continuing medical education courses; training services for medical visitors in the field of medicine and healthcare; providing online electronic publications, in the nature of articles in the field of medicine and healthcare, not downloadable, conducting of instructional seminars in the field of medicine and healthcare; providing continuing medical education courses; on-line electronic publishing services of books and periodicals; arranging and conducting of conferences in the field of medicine and healthcare; arranging and conducting of congresses in the field of medicine and healthcare; arrangement and conducting of conventions for educational purposes in the field of medicine and healthcare; organization of seminars in the field of medicine and healthcare; arranging and conducting of colloquiums in the field of medicine and healthcare; arranging and conducting of workshops in the field of medicine and healthcare; arranging, conducting and organization of seminars in the field of medicine and healthcare; arranging and conducting of lectures in the field of medicine and healthcare; creation, namely, scriptwriting of podcasts for non-advertising purposes
41 - Éducation, divertissements, activités sportives et culturelles
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
(1) Paper, cardboard; printed matter, namely, scientific publications, periodical publications, and circulars, pamphlets, handbooks, curriculum, information cards, and photographs, namely, handbooks, exercise books, notebooks, reference books, books; paper; writing stationery; all the aforesaid goods in the field of aesthetics, beauty and medicine. (1) Advertising; promotion services; all the aforesaid services in the fields of aesthetics, beauty and medicine.
(2) Publication and editing of scientific papers; conducting of seminars, congresses, arranging of congresses, lecture colloquiums and workshops; training courses for doctors; all the aforesaid services in the fields of aesthetics, beauty and medicine.
(3) Skin treatment services; consultancy and information services relating to pharmaceutical and medical products; consultancy and information services relating to medical devices and instruments; consultations in the field of aesthetics, beauty and medicine.
41 - Éducation, divertissements, activités sportives et culturelles
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
paper, cardboard; printed matter, namely, scientific publications in the nature of books, journals, scientific articles, magazines, brochures, pamphlets, periodical publications in the field of aesthetics, beauty and medicine, and circulars charts, pamphlets, handbooks, curriculum, information cards, and photographs, namely, handbooks, exercise books, notebooks, reference books, books, all in the field of aesthetics, beauty and medicine; paper; writing stationery paper and envelopes; all the aforesaid goods in the field of aesthetics, beauty and medicine advertising services; sales promotion services; all the aforesaid services in the fields of aesthetics, beauty, and medicine publication and editing of scientific newspapers; conducting of seminars and congresses, and arranging of congresses, lecture colloquiums and workshops in the field of aesthetics, beauty, and medicine; training courses for doctors in the field of in the field of aesthetics, beauty, and medicine; all the aforesaid services in the fields of aesthetics, beauty and medicine cosmetic skin care treatment services; medical consultancy and information services relating to pharmaceutical and medical products; medical consultancy and information services relating to medical devices and instruments; consultations in the field of medical aesthetics, beauty and medicine
35.
INJECTABLE COMPOSITION FOR SKIN AND SOFT TISSUE AUGMENTATION
The present invention relates to the synergistic effect of calcium hydroxyapatite particles and hyaluronic acid on the bio-stimulation. The invention refers to an injectable composition comprising one or more types of calcium hydroxyapatite particles and hyaluronic acid and to a method for preparing such injectable composition. Furthermore, it relates to a cosmetic method for improving appearance of the skin and/or contour of a subject by means of the injectable composition. Moreover, the invention refers to the injectable composition for use in a method of treating a pathologic condition associated with pathologic deterioration of connective tissue.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Pharmaceutical products for use in dermatology in the aesthetic field; pharmaceutical products for relaxing muscles; pharmaceutical products for the treatment of wrinkles and facial fines and for the treatment of cerebral and neurological disorders, diseases and conditions; medical products for use in dermatology in the aesthetic field, namely, medicated dermatological preparations and substances; medical products for relaxing muscles, namely, muscle relaxants; medical products in the nature of botulinum toxin for the treatment of wrinkles and facial lines and the treatment of cerebral and neurological disorders, disease and conditions; medicaments for human medical use for the treatment of cerebral and neurological disorders, diseases and conditions; prefilled syringes sold filled with botulinum toxin for medical and pharmaceutical use in dermatology in the aesthetic field, for relaxing muscles, for the treatment of wrinkles and facial lines and for the treatment of cerebral and neurological disorders, diseases and conditions Medical apparatus and instruments for medical use in dermatological procedures; hypodermic needles; hypodermic needles for injections; syringes for medical purposes; systems for injections consisting of hypodermic needles for injections; syringes for medical purposes and injection devices for pharmaceuticals in the nature of botulinum toxin; injection equipment for single doses, namely, needles for injections; containers for the administration of medicines, namely, containers for botulinum toxin
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
(1) Pharmaceutical preparations; pharmaceutical products for use in the aesthetic field and the treatment of diseases; medical preparations; medical products; medicine for human purposes; pharmaceuticals; pre-filied syringes for medical purposes (pharmaceuticals); nervines.
(2) Medical instruments and devices; hypodermic needles; medical syringes; systems for injecting medical or pharmaceutical fluids; one-dose injectable devices of medical or pharmaceutical fluids; receptacles for applying medicine.
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Books; printed matter; printed instructional and teaching material; instructional and teaching material (except apparatus); paper and stationery; printed publications; periodical publications; magazines [periodicals]; newspapers. Online advertising; advertising; provision of an on-line marketplace for buyers and sellers of goods and services; on-line advertising on a computer network. Training in the area of pharmacy; training in the medical field; vocational training and further education; vocational training services; vocational training services for medical personnel; vocational training services in the area of cosmetics; provision of online publications; carrying out further education seminars; providing electronic publications [non-downloadable]; publication of printed matter; publication of printed matter in the medical field; providing non-downloadable online electronic publications; providing on-line publications [non-downloadable]; organization of conferences for educational purposes; publication of electronic publications, printed matter and printed publications and providing non-downloadable online publications; arranging, conducting and organization of workshops; arranging, conducting and organization of colloquiums; organization of congresses; organization of seminars; education services, namely, conducting of presentations; arranging, conducting and organization of seminars; publication and provision of books; publication, rental and leasing of printed matter; publication and provision of non-downloadable online publications and electronic publications; publication of magazines and providing on-line non-downloadable magazines. Research in the medical field; research and development services; medical research; medical and pharmaceutical research services; pharmaceutical research and development; scientific research and development; scientific and technological services.
39.
SYRINGE BARREL WITH VARYING SILICONE LAYER THICKNESSES, SYRINGE COMPRISING SAME AND USES THEREOF
The present invention relates to a syringe barrel having an interior surface coated with a silicone film having a thickness in the range of 5 nm to 100 nm. It further relates to a method for manufacturing said syringe barrel comprising the step of reducing an initial thickness of a pre-formed silicone film on the interior surface of a syringe barrel to a thickness within the range of about 5 nm to about 100 nm by exposing the syringe barrel to an organic solvent or by subjecting the syringe barrel to mechanical treatment. Furthermore, the present invention relates to a syringe comprising the syringe barrel of the invention, a kit comprising said syringe, and cosmetic and therapeutic uses of said syringe.
B05C 9/14 - Appareillages ou installations pour appliquer des liquides ou d'autres matériaux fluides aux surfaces par des moyens non prévus dans l'un des groupes , ou dans lesquels le moyen pour déposer le liquide ou autre matériau fluide n'est pas important pour appliquer un liquide ou autre matériau fluide et exécuter une opération auxiliaire l'opération auxiliaire nécessitant un chauffage
B05D 5/08 - Procédés pour appliquer des liquides ou d'autres matériaux fluides aux surfaces pour obtenir des effets, finis ou des structures de surface particuliers pour obtenir une surface antifriction ou anti-adhésive
C03C 17/30 - Traitement de surface du verre, p.ex. du verre dévitrifié, autre que sous forme de fibres ou de filaments, par revêtement par des matières organiques avec des composés contenant du silicium
B05D 3/12 - Traitement préalable des surfaces sur lesquelles des liquides ou d'autres matériaux fluides doivent être appliqués; Traitement ultérieur des revêtements appliqués, p.ex. traitement intermédiaire d'un revêtement déjà appliqué, pour préparer les applications ultérieures de liquides ou d'autres matériaux fluides par des moyens mécaniques
40.
HYALURONIC ACID DERMAL FILLERS CROSSLINKED WITH POLYETHYLENE GLYCOL DIGLYCIDYL ETHER, METHOD FOR MAKING SAME AND USES THEREOF
222-O- repetitive units of 8 to 90. Furthermore, the present invention relates to a method for preparing said dermal filler composition and its use for cosmetic purposes.
A process for producing a composition comprising a crosslinked hydrogel is proposed. The process comprises providing a container body (2), wherein the container body (2) has a body inner wall (21) and a body outer wall (22), wherein the body inner (21) wall is configured to be tempered, filling of a fluid (7) comprising at least a mixture of a polymer and water into the container body (2), and agitating the fluid. For crosslinking of the fluid (7), a container insert (3) is provided, the container insert (3) having an insert outer wall (32) which is configured to be tempered and a container assembly (1) is formed by inserting the container insert (3) into the container body (2) so that the insert outer wall (32) of the container insert (3) and the body inner wall (21) of the container body (2) are separated by a gap (9) of constant width and define a volume (6) for receiving the fluid (7). Crosslinking of the fluid (7) is then performed while tempering the insert outer wall (32) and the body inner wall (21) to form a crosslinked hydrogel.
The invention proposes a method for preparing a cross-linked material, comprising forming amide bonds that conjugate one or more fibroin moieties with one or more polysaccharide moieties. The invention further relates to a cross-linked material obtainable from such method and to an injectable composition comprising the obtained cross-linked material. The cross-linked material can be a hydrogel and/or a super-volumizer and can be used in cosmetic and pharmaceutical applications.
The invention proposes a method for preparing a cross-linked material, comprising forming amide bonds that conjugate one or more fibroin moieties with one or more polysaccharide moieties. The invention further relates to a cross-linked material obtainable from such method and to an injectable composition comprising the obtained cross-linked material. The cross-linked material can be a hydrogel and/or a super-volumizer and can be used in cosmetic and pharmaceutical applications.
The present invention relates to methods for reducing facial lines or wrinkles of the skin or of removing facial asymmetries by administering a composition containing the neurotoxic component of a Clostridium botulinum toxin complex, wherein the composition may be devoid of any other protein of the Clostridium botulinum toxin complex and wherein the composition is administered at short intervals and/or in high doses.
The present invention relates to methods for treating diseases and disorders by administering a composition containing the neurotoxic component of a Clostridium botulinum toxin complex, wherein the composition may be devoid of any other protein of the Clostridium botulinum toxin complex and wherein the composition is administered at short intervals and/or in high doses.
The present invention relates a botulinum toxin prefilled syringe system with desirable injection force characteristics, in particular low gliding force and low break loose force, comprising a syringe barrel of glass containing a liquid botulinum toxin composition, a plunger stopper and a closure device such as a tip cap or a needle shield. In addition, the present invention relates to a kit comprising the botulinum toxin prefilled syringe system, and optionally instructions for use, and to the use of the botulinum toxin prefilled syringe system in therapeutic and cosmetic applications.
A61M 5/315 - Pistons; Tiges de piston; Guidage, blocage, ou limitation des mouvements de la tige; Accessoires disposés sur la tige pour faciliter le dosage
A61M 5/48 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaire; Accessoires à cet effet, p.ex. dispositifs de remplissage ou de nettoyage, appuis-bras avec des moyens pour faire varier, pour réguler, pour indiquer ou pour limiter la pression d'injection
09 - Appareils et instruments scientifiques et électriques
16 - Papier, carton et produits en ces matières
35 - Publicité; Affaires commerciales
41 - Éducation, divertissements, activités sportives et culturelles
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Downloadable mobile applications for administering reward and customer loyalty program accounts Printed educational materials in the field of dermatology, medical aesthetics, and neurology; Printed materials, namely, written articles in the field of dermatology, medical aesthetics, and neurology; Printed training materials in the field of dermatology, medical aesthetics, and neurology Advertising, marketing and promotion services in the field of dermatological, medical aesthetic, and neurological products; Arranging and conducting incentive reward programs to promote the sale of dermatological, medical aesthetic, and neurological products; Business administration of patient reimbursement programs; Marketing services in the nature of promotion of third-party goods and services by brand ambassadors; Providing consumer information in the field of dermatology, medical aesthetics and neurology On-line video journals, namely, vlogs featuring nondownloadable videos in the field of dermatology, medical aesthetics and neurology; Providing a website featuring blogs and non-downloadable publications in the nature of articles and brochures in the field(s) of dermatology, medical aesthetics and neurology; Providing a website featuring non-downloadable photographs in the field of dermatology, medical aesthetics and neurology Providing a website featuring information in the field of medical aesthetics, neurological, and dermatological health; Providing health information; Providing health information in the field of dermatology, medical aesthetics and neurology
51.
NOVEL USES OF BOTULINUM NEUROTOXIN FOR THE TREATMENT OF TREMOR
This invention relates to novel uses of botulinum neurotoxin in treating a tremor, in particular to a botulinum neurotoxin for use in treating a tremor of the upper limb comprising the administration of a botulinum neurotoxin to at least one muscle of the forearm/wrist, elbow and shoulder, wherein the botulinum neurotoxin is administered to at least one muscle of the forearm/wrist selected from the group of M. extensor carpi ulnaris (ECU), M. extensor carpi radialis (ECR), M. pronator quadratus (PQ) and M. supinator in a dosage in the range of 2 to 6 U and wherein the botulinum neurotoxin is administered to at least one muscle of the elbow in a dosage of about 20 U and to at least one muscle of the shoulder in a dosage of about 15 U.
The present invention relates to a prefilled plastic container, such as a plastic syringe, comprising an aqueous botulinum toxin formulation. The aqueous botulinum toxin formulation in the prefilled plastic container is stable for a prolonged time period. Furthermore, the present invention relates to a kit comprising the prefilled plastic container, and to the use of the prefilled plastic container for therapeutic and cosmetic purposes.
A61K 38/48 - Hydrolases (3) agissant sur des liaisons peptidiques (3.4)
A61Q 19/08 - Préparations contre le vieillissement
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 8/64 - Protéines; Peptides; Leurs dérivés ou produits de dégradation
A61K 47/26 - Hydrates de carbone, p.ex. polyols ou sucres alcoolisés, sucres aminés, acides nucléiques, mono-, di- ou oligosaccharides; Leurs dérivés, p.ex. polysorbates, esters d’acide gras de sorbitan ou glycyrrhizine
A61M 5/315 - Pistons; Tiges de piston; Guidage, blocage, ou limitation des mouvements de la tige; Accessoires disposés sur la tige pour faciliter le dosage
A61M 5/24 - Seringues à ampoules, c. à d. seringues à aiguille utilisables avec des ampoules ou des cartouches échangeables, p.ex. automatiques
A61M 5/32 - Seringues - Parties constitutives - Parties constitutives des aiguilles relatives au raccordement de celles-ci à la seringue ou au manchon; Accessoires pour introduire l'aiguille dans le corps ou l'y maintenir; Dispositifs pour la protection des aiguilles
53.
PLUNGER AND FINGER GRIP FOR A SYRINGE ASSEMBLY, METHOD FOR MAKING THEM, SYRINGE ASSEMBLY, KIT AND USE OF THE SAME
The present invention relates to a plunger (20) and a finger grip (30) for a syringe assembly (100), methods for manufacturing them, to a syringe assembly (100), to a kit comprising parts of a syringe assembly (100), and to the use of a syringe assembly (100) or of a kit, wherein the syringe assembly (100) comprises a syringe barrel (10), a finger grip (30) having flanges (31, 32), and a plunger (20) having a plunger rod (21) and a plunger head (22). The plunger (20) comprises a grip pad (23) made by injection molding and attached to a proximal facing surface (24) of the plunger head. The finger grip (20) comprises a grip pad (35) also made by injection molding and attached to a distal facing surface of at least one flange (31, 32) of the finger grip (30).
The present invention relates to a plunger (20) and a finger grip (30) for a syringe assembly (100), methods for manufacturing them, to a syringe assembly (100), to a kit comprising parts of a syringe assembly (100), and to the use of a syringe assembly (100) or of a kit, wherein the syringe assembly (100) comprises a syringe barrel (10), a finger grip (30) having flanges (31, 32), and a plunger (20) having a plunger rod (21) and a plunger head (22). The plunger (20) comprises a grip pad (23) made by injection molding and attached to a proximal facing surface (24) of the plunger head. The finger grip (20) comprises a grip pad (35) also made by injection molding and attached to a distal facing surface of at least one flange (31, 32) of the finger grip (30).
The present invention relates to a modified hyaluronic acid derivative, wherein the —CH2—OH group of at least one N-acetyl-D-glucosamine unit is modified into an aldehyde group having the structure —CH2—O—CH2—CHO, methods for preparing same and applications thereof.
The present invention relates the use of botulinum toxin for the treatment of facial wrinkles, wherein botulinum toxin is administered at high doses (e.g., 50 U to 200 U) using small injection volumes (e.g., 0.05 ml to 0.35 ml). Furthermore, the present invention relates to a method for the treatment of facial wrinkles (e.g., glabellar frown lines) by injecting small volumes of a highly concentrated botulinum toxin solution into a target facial area of a subject.
The present invention relates the use of botulinum toxin for the treatment of facial wrinkles, wherein botulinum toxin is administered at high doses (e.g., 50 U to 200 U) using small injection volumes (e.g., 0.05 ml to 0.35 ml). Furthermore, the present invention relates to a method for the treatment of facial wrinkles (e.g., glabellar frown lines) by injecting small volumes of a highly concentrated botulinum toxin solution into a target facial area of a subject.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Pharmaceutical preparations; pharmaceutical preparations for
dermatological use; pharmaceutical preparations for skin
care; pharmaceutical preparations for treament of skin
problems.
The present invention relates to a vial that is at least partially filled with an aqueous formulation of a neurotoxin, preferably botulinum toxin, to the manufacture of the vial and to the use thereof. The aqueous formulation of a neurotoxin is stable in the vial for a prolonged period of time.
A61J 1/14 - Récipients spécialement adaptés à des fins médicales ou pharmaceutiques - Détails; Accessoires à cet effet
B65B 3/00 - Emballage de matériaux plastiques, de semi-liquides, de liquides ou de liquides et solides mélangés, dans des réceptacles ou récipients individuels, p.ex. dans des sacs ou sachets, boîtes, cartons, bidons ou pots
B65B 31/02 - Remplissage, fermeture, ou remplissage et fermeture, de réceptacles dans des chambres maintenues en dépression ou en surpression ou contenant une atmosphère spéciale, p.ex. du gaz inerte
03 - Produits cosmétiques et préparations de toilette; préparations pour blanchir, nettoyer, polir et abraser.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
16 - Papier, carton et produits en ces matières
35 - Publicité; Affaires commerciales
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Cosmetics. Pharmaceutical preparations; sanitary preparations for
medical use; medical preparations; dermatological
preparations; dermatological pharmaceutical products;
pre-filled syringes for medical purposes; filled syringes
for medical purposes [containing pharmaceuticals];
injectable dermal fillers. Medical instruments; medical apparatus and devices; medical
apparatus and instruments; medical syringes; injection
syringes; syringes for injections; syringes for medical use. Books; newspapers; periodicals; magazines; pamphlets;
publications (printed -); instructional materials; teaching
materials; stationery; printed matter. Advertising; advertising, marketing and promotion services;
loyalty, incentive and bonus program services. Publication of periodicals; publication of newspapers;
publication of books; publication of printed matter in
electronic form; arranging conferences; arranging of
seminars; arranging and conducting of congresses; arranging
and conducting of colloquiums; arranging of workshops and
seminars; medical training and teaching; training services
for medical visitors; education services relating to
medicine. Scientific and technological services; product research and
development services.
The present invention relates to a prefilled glass container, such as a prefilled glass syringe, comprising an aqueous botulinum toxin formulation. The aqueous botulinum toxin formulation in the prefilled container is stable at low to ambient temperature for a prolonged time period. Furthermore, the present invention relates to a kit comprising the botulinum toxin prefilled container, and to the use of the botulinum toxin prefilled container in therapeutic and cosmetic applications.
A61K 38/48 - Hydrolases (3) agissant sur des liaisons peptidiques (3.4)
A61Q 19/08 - Préparations contre le vieillissement
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61M 5/315 - Pistons; Tiges de piston; Guidage, blocage, ou limitation des mouvements de la tige; Accessoires disposés sur la tige pour faciliter le dosage
A61K 47/26 - Hydrates de carbone, p.ex. polyols ou sucres alcoolisés, sucres aminés, acides nucléiques, mono-, di- ou oligosaccharides; Leurs dérivés, p.ex. polysorbates, esters d’acide gras de sorbitan ou glycyrrhizine
A61K 47/42 - Protéines; Polypeptides; Leurs produits de dégradation; Leurs dérivés p.ex. albumine, gélatine ou zéine
A61K 8/64 - Protéines; Peptides; Leurs dérivés ou produits de dégradation
62.
METHOD FOR DYNAMIC FILTRATION OF A CROSS-LINKED HYDROGEL
The present invention relates to a method for dynamic filtration of a cross-linked biopolymer-based hydrogel to remove unwanted molecules from the gel. In particular, the invention relates to dynamic filtration of a hyaluronic acid hydrogel using a dynamic filtration construction with rotating and semipermeable filter discs.
A61K 31/167 - Amides, p.ex. acides hydroxamiques ayant des cycles aromatiques, p.ex. colchicine, aténolol, progabide ayant l'atome d'azote d'un groupe carboxamide lié directement au cycle aromatique, p.ex. lidocaïne, paracétamol
C08B 37/08 - Chitine; Sulfate de chondroïtine; Acide hyaluronique; Leurs dérivés
B01D 69/02 - Membranes semi-perméables destinées aux procédés ou aux appareils de séparation, caractérisées par leur forme, leur structure ou leurs propriétés; Procédés spécialement adaptés à leur fabrication caractérisées par leurs propriétés
B01D 63/16 - Modules rotatifs, vibrants ou à mouvement alternatif
63.
FATTY ACID-GRAFTED HYALURONIC ACID, DERMAL FILLER FORMULATIONS COMPRISING SAME, PROCESS FOR PREPARATION AND USE THEREOF
The present invention relates to fatty acid-grafted hyaluronic acid (FA-g-HA), and a sterile microsphere-based dermal filler formulation and a sterile crosslinked hyaluronic acid-based dermal filler formulation each comprising the FA-g-HA. The present invention further relates to processes for the preparation of the FA-g-HA and the dermal filler formulations comprising the FA-g-HA, and their use in cosmetic applications.
The present invention relates to the synergistic effect of calcium hydroxyapatite particles and hyaluronic acid on the bio-stimulation. The invention refers to an injectable composition comprising one or more types of calcium hydroxyapatite particles and hyaluronic acid and to a method for preparing such injectable composition. Furthermore, it relates to a cosmetic method for improving appearance of the skin and/or contour of a subject by means of the injectable composition. Moreover, the invention refers to the injectable composition for use in a method of treating a pathologic condition associated with pathologic deterioration of connective tissue.
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Dermatology services; Services for the care of the skin; Medical services for treatment of the skin; Human hygiene and beauty care; Consultation services relating to skin care; Cosmetic body care services.
66.
PROCESS FOR PRODUCING A COMPOSITION COMPRISING A CROSSLINKED HYDROGEL
A process for producing a composition comprising a crosslinked hydrogel is proposed. The process comprises providing a container body (2), wherein the container body (2) has a body inner wall (21) and a body outer wall (22), wherein the body inner (21) wall is configured to be tempered, filling of a fluid (7) comprising at least a mixture of a polymer and water into the container body (2), and agitating the fluid. For crosslinking of the fluid (7), a container insert (3) is provided, the container insert (3) having an insert outer wall (32) which is configured to be tempered and a container assembly (1) is formed by inserting the container insert (3) into the container body (2) so that the insert outer wall (32) of the container insert (3) and the body inner wall (21) of the container body (2) are separated by a gap (9) of constant width and define a volume (6) for receiving the fluid (7). Crosslinking of the fluid (7) is then performed while tempering the insert outer wall (32) and the body inner wall (21) to form a crosslinked hydrogel.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
(1) Pharmaceutical preparations, namely injectable pharmaceutical solutions for intradermal or subcutaneous application for facial and body sculpting, skin tightening and smoothing; dermatological preparations, namely injectable preparations made of solutions of hyaluronic acid for medical and aesthetic purposes, dermatological pharmaceutical products, namely medicated skin care preparations for treating, reducing, and preventing lines, pores, and loss of skin firmness; pre-filled syringes with a dermal injectable filling for smoothing wrinkles and to provide volumization of the injected area for medical purposes, pre-filled syringes with hyaluronic acid for medical use; injectable dermal fillers
(2) Medical instruments, namely injection instruments without needles, injection syringes, syringes for injections, syringes for medical use
03 - Produits cosmétiques et préparations de toilette; préparations pour blanchir, nettoyer, polir et abraser.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
16 - Papier, carton et produits en ces matières
35 - Publicité; Affaires commerciales
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Cosmetics Pharmaceutical preparations for use in aesthetic surgery and dermatology and for use in soft tissue augmentation of the jawline contour; medical preparations namely, for biocompatible injections consisting of dermal fillers for use as treatment alternatives to plastic surgery and internal augmentation; medicated dermatological preparations and substances; dermatological pharmaceutical products; Syringes sold filled with dermal fillers; injectable dermal fillers Medical syringes; injection syringes; syringes for injections; Disposable hypodermic syringes for medical use Printed books in the field of pharmaceuticals, dermatology, aesthetics, skincare, and augmentation; Printed newspapers; Printed periodicals in the field of pharmaceuticals, dermatology, aesthetics, skincare, and augmentation; Printed magazines in the field of pharmaceuticals, dermatology, aesthetics, skincare, and augmentation; Printed pamphlets in the field of pharmaceuticals, dermatology, aesthetics, skincare, and augmentation; Printed publications, namely, books, hand-outs, workbooks in the field of pharmaceuticals, dermatology, aesthetics, skincare, and augmentation; Printed instructional and teaching materials in the field of pharmaceuticals, dermatology, aesthetics, skincare, and augmentation; Printed instructional and teaching materials in the field of dermatology, aesthetics, skincare, and augmentation; stationery; printed matter, namely, printed lessons on treatments in the field of pharmaceuticals, dermatology, aesthetics, skincare, and augmentation; printed reports featuring treatment methods in the field of pharmaceuticals, dermatology, aesthetics, skincare, and augmentation; printed newsletters about pharmaceuticals, dermatology, aesthetics, skincare, and augmentation Advertising services; advertising, marketing and promotion services; Administration of a customer loyalty program which provides discounts on dermatological and aesthetics goods or services; Arranging and conducting incentive reward programs to promote the sale of dermatological and aesthetics good or services Publication of periodicals; publication of newspapers; publication of books; Publication of electronic newspapers accessible via a global computer network; Arranging and conducting of conferences in the field of pharmaceuticals, aesthetics, dermatology, medicine or cosmetics; Arranging and conducting of seminars in the field of pharmaceuticals, aesthetics, dermatology, medicine or cosmetics; Arranging and conducting of congresses in the field of pharmaceuticals, aesthetics, dermatology, medicine or cosmetics; Arranging and conducting of colloquiums in the field of pharmaceuticals, aesthetics, dermatology, medicine or cosmetics; Arranging and conducting of seminars and workshops in the field of pharmaceuticals, aesthetics, dermatology, medicine or cosmetics; medical training and teaching; Providing continuing medical education courses, training services in the field of aesthetics and dermatology; Education services, namely, providing classes, seminars, workshops relating to aesthetics and dermatology Scientific and technological services, namely, scientific analysis, testing, research and product design in the field of aesthetics and medicine; product research and development services for others in the field aesthetics and dermatology
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Pharmaceuticals, namely, pharmaceutical preparations for scars, skin care, skin wounds, and the treatment of damaged skin and tissue; chemical products for medicinal purposes and health care, namely, chemical reagents for medical purposes and chemical preparations for scars, skin care, skin wounds, and the treatment of damaged skin and tissue; pharmaceutical drugs, namely, pharmaceuticals for the treatment of scars, skin care, skin wounds, and the treatment of damaged skin and tissue
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Chemical substances, materials and preparations for
industrial purposes in raw material in the form of powders,
liquids or pastes; chemical products as ingredients in form
of powders, liquids or pastes for manufacturing processes. Pharmaceutical preparations. Scientific and technological services; development and
testing of chemical manufacturing processes.
71.
Means and methods for the determination of the biological activity of BoNT/E in cells
The present invention pertains to a polyclonal or monoclonal antibody specifically binding to BoNT/E-cleaved SNAP-25. Further, the invention provides a method for directly determining the biological activity of BoNT/E in cells, comprising the steps of: a) incubating cells susceptible to BoNT/E intoxication with BoNT/E for a time and under conditions which allow for the BoNT/E to exert its biological activity; b) fixing the cells and, optionally, permeabilizing the cells with a detergent; c) contacting the cells with at least a first capture antibody specifically binding to non-cleaved and BoNT/E-cleaved SNAP-25, and with at least a second capture antibody specifically binding to BoNT/E-cleaved SNAP-25, wherein the second capture antibody is an antibody of the invention, under conditions which allow for binding of said capture antibodies to the indicated substrates; d) contacting the cells with at least a first detection antibody specifically binding to the first capture antibody, under conditions which allow for binding of said first detection antibody to said first capture antibody, thus forming first detection complexes, and with at least a second detection antibody specifically binding to the second capture antibody, under conditions which allow for binding of said second detection antibody to said second capture antibody, thus forming second detection complexes, and wherein the first detection antibody is different from the second detection antibody; e) determining the amount of the first and second detection complexes of step d); and f) calculating the amount of SNAP-25 cleaved by BoNT/E in said cells by means of the second detection complexes, thereby determining the biological activity of BoNT/E in said cells. Furthermore, the invention relates to a kit for carrying out the method of the invention.
G01N 33/50 - Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique
C07K 16/18 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains
C07K 16/12 - Immunoglobulines, p.ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant de bactéries
G01N 33/573 - Tests immunologiques; Tests faisant intervenir la formation de liaisons biospécifiques; Matériaux à cet effet pour enzymes ou isoenzymes
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
(1) Chemical substances and proteins, namely incobotulinumtoxin and Clostridium botulinum Hall A; materials and preparations for industrial purposes in raw material in the form of powders, liquids or pastes, namely incobotulinumtoxin and Clostridium botulinum Hall A; chemical products as ingredients in form of powders, liquids or pastes for manufacturing processes, namely incobotulinumtoxin and Clostridium botulinum Hall A.
(2) Pharmaceutical preparations, namely incobotulinumtoxinA for medical and aesthetic use. (1) Scientific and technological research in the field of medical and aesthetic treatment made with incobotulinumtoxinA; development and testing of chemical manufacturing processes for medical and aesthetic treatments made with incobotulinumtoxinA.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Chemical substances, materials and preparations for industrial purposes in raw material in the form of powders, liquids or pastes for the purification of pharmaceuticals in the field of dermatology, neurology and aesthetics; chemical products as ingredients in form of powders, liquids or pastes for manufacturing processes for the purification of pharmaceuticals in the field of dermatology, neurology and aesthetics Pharmaceutical preparations for use in the field of dermatology, neurology and aesthetics Scientific and technological services, namely, development and testing of the effectiveness of chemical manufacturing processes
74.
Dermal filler based on crosslinked hyaluronic acid, calcium phosphate material particles and carboxymethyl cellulose, a process for preparing same and uses thereof
The present invention relates to a dermal filler composition based on crosslinked hyaluronic acid, calcium phosphate material particles and carboxymethyl cellulose. The present invention further provides a process for preparing said dermal filler composition, and its use in cosmetic treatments such as for improvement of skin quality.
A61K 31/167 - Amides, p.ex. acides hydroxamiques ayant des cycles aromatiques, p.ex. colchicine, aténolol, progabide ayant l'atome d'azote d'un groupe carboxamide lié directement au cycle aromatique, p.ex. lidocaïne, paracétamol
The present invention relates to a porous material having a scaffold comprising: one or more fibroin moieties A and one or more polysaccharide moieties B, wherein A and B are directly conjugated with another without an interconnecting linker structure. Moreover, the present invention refers to a method for preparing a porous material. The present invention further relates to an injectable composition comprising a particulate porous material according to the invention and to cosmetic and therapeutic uses thereof such as facial and body re-shaping as well as regenerating tissue.
The invention relates to novel recombinant single-chain precursor botulinum neurotoxins serotype A comprising at least one additional domain and least one amino acid modification of the heavy chain of the neurotoxin. The novel recombinant single-chain precursor botulinum neurotoxins further comprises at least one cleavage site for a protease selected from the group consisting of thrombin, HRV3C, Tobacco Etch Vims protease, enterokinase and factor Xa. The invention further relates to novel recombinant botulinum neurotoxins serotype A exhibiting an increased duration of effect.
A61K 38/48 - Hydrolases (3) agissant sur des liaisons peptidiques (3.4)
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 47/32 - Composés macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone, p.ex. carbomères
A61K 47/10 - Alcools; Phénols; Leurs sels, p.ex. glycérol; Polyéthylène glycols [PEG]; Poloxamères; Alkyléthers de PEG/POE
A61K 47/36 - Polysaccharides; Leurs dérivés, p.ex. gommes, amidon, alginate, dextrine, acide hyaluronique, chitosane, inuline, agar-agar ou pectine
03 - Produits cosmétiques et préparations de toilette; préparations pour blanchir, nettoyer, polir et abraser.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
16 - Papier, carton et produits en ces matières
35 - Publicité; Affaires commerciales
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Cosmetics. Pharmaceutical preparations; Sanitary preparations for medical use; Medical preparations; Dermatological preparations; Dermatological pharmaceutical products; Pre-filled syringes for medical purposes; Filled syringes for medical purposes [containing pharmaceuticals]; Injectable dermal fillers. Medical instruments; Medical apparatus and devices; Medical apparatus and instruments; Medical syringes; Injection syringes; Syringes for injections; Syringes for medical use. Books; Newspapers; Periodicals; Magazines; Pamphlets; Publications (Printed -); Instructional materials; Teaching materials; Stationery; Printed matter. Advertising; Advertising, marketing and promotion services; Loyalty, incentive and bonus program services. Publication of periodicals; Publication of newspapers; Publication of books; Publication of printed matter in electronic form; Arranging conferences; Arranging of seminars; Arranging and conducting of congresses; Arranging and conducting of colloquiums; Arranging of workshops and seminars; Medical training and teaching; Training services for medical visitors; Education services relating to medicine. Science and technology services; Research and development services.
Administration of a customer loyalty program which provides discounts on dermatological and aesthetics goods or services; Arranging and conducting incentive reward programs to promote the sale of dermatological and aesthetics good or services
80.
NOVEL RECOMBINANT BOTULINUM TOXIN WITH INCREASED DURATION OF EFFECT
This invention relates to novel recombinant clostridial neurotoxins exhibiting an increased duration of effect and to methods for the manufacture of such recombinant clostridial neurotoxins. These novel recombinant clostridial neurotoxins comprise at least one domain wherein said domain comprises an amino acid sequence consisting of at least 50 amino acid residues, wherein said amino acid sequence consists of at least one proline and at least one alanine residue. The invention relates also to novel recombinant clostridial neurotoxins comprising at least one domain wherein said domain comprises an amino acid sequence consisting of at least 50 amino acid residues, wherein said domain comprises a plurality of specific amino acid repeats consisting of proline, alanine and tyrosine residues, or proline, alanine and glutamine residues, or proline, alanine and threonine residues.
This invention relates to improved uses of botulinum neurotoxins in the treatment of sialorrhea or diseases or conditions relating to increased saliva production. In particular are botulinum neurotoxins disclosed which are administered into parotid and submandibular glands in a dose ratio between 1.45 to 1 and 1.7 to 1.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
16 - Papier, carton et produits en ces matières
35 - Publicité; Affaires commerciales
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
(1) Pharmaceutical products, namely botulinum toxin, injectable dermal filler, pharmaceutical preparations, namely biodegradable implants for use in guided tissue regeneration, injectable dermal filler implants, topical ultrasound gel for medical and therapeutic use, medical products for dermatology, namely pre-filled syringes with dermal fillers, all aforesaid in the field of aesthetic, beauty and medicine.
(2) Medical instruments and apparatus, namely injection instruments without needles, injection needles, syringes for medical purposes and for injections, medical ultrasound apparatus, all aforesaid in the field of aesthetic, beauty and medicine.
(3) Paper cardboard; Printed matter, namely medical publications, periodical publications, as well as newsletters, brochures, manuals, curricula, informational cards, photographs, and brochures in the field of neuroscience, pharmaceuticals, dermatological and aesthetic dermatology, instructional and teaching material (except apparatus), namely manuals, exercise books, notebooks, memo books, reference books, and books, paper and writing stationery, all aforesaid in the field of aesthetic, beauty and medicine. (1) Advertising, namely administration of a discount program for enabling participants to obtain discounts on goods and services through use of a discount membership card and promotional coupon and voucher programs, administration of customer incentive programs by setting goals, monitoring progress and providing rewards, discounts and rebates, sales and promotional incentive schemes and promotional services, namely provision of bonus incentive rewards to customers, promoting the sale of goods and services through promotional contests and the distribution of related printed material, all aforesaid in the field of aesthetic, beauty and medicine.
(2) Publishing and issuing scientific papers in relation to medical technology; arranging of seminars, conference, congresses, talks colloquiums and workshops in the field of medicine and aesthetics; scientific training and further training for doctors, further training events for doctors, namely training for handling scientific instruments and apparatus for research in laboratories, practical training in the field of medicine and aesthetics, arranging and conducting classes, workshops and training in the field of medicine and aesthetics, organization of conferences, seminars, working groups, research groups and conventions in the field of aesthetic, beauty and medicine.
(3) Services in the field of science and technology and research and development related thereto, namely scientific and technological research in the field of medical treatment made with botulinum toxin, injectable dermal filler and ultrasounds, development and testing of manufacturing processes for treatments made with botulinum toxin, injectable dermal filler and ultrasounds, all aforesaid in the field of aesthetic, beauty and medicine.
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Books, printed matter, printed instructional and teaching
material; instructional and teaching material [except
apparatus]; paper and stationery, printed periodical
publications; periodical publications; magazines
[periodicals]; newspapers. Online advertisement; advertisement; advertisement services
for goods and services via websites; advertisement,
including online-advertisement via a computer network. Training in the area of pharmacy; training in the medical
field; vocational training and further education; vocational
training services; vocational training services for medical
personnel; vocational training services in the area of
cosmetics; provision of online publications; carrying out
further education seminars; electronic publications (terms
considered too vague by the International Bureau - rule 13
(2) (b) of the Regulations); issuance and publication of
printed matter; issuance of medical publications; issuance
of online publications; issuance of publications;
organization and implementation of congresses; organization
and hosting of congresses; organization of seminars and
congresses in the field of medicine; publications
[publication and issuance]; organization and implementation
of workshops; organization and management of colloquiums;
organization of seminars; organization of presentations;
organization, implementation and carrying out of seminars;
publication and issuance of books; publication and issuance
of printed matter; publication and issuance of publications;
publication and issuance of magazines. Research in the medical field; research and development
services (term considered too vague in the opinion of the
International Bureau - Rule 13 (2) (b) of the Regulations);
medical research; medical and pharmaceutical research
services; pharmaceutical research and development;
scientific research and development; scientific and
technological services.
84.
NOVEL USES OF BOTULINUM NEUROTOXIN FOR THE TREATMENT OF TREMOR
This invention relates to novel uses of botulinum neurotoxin in treating a tremor, in particular to a botulinum neurotoxin for use in treating a tremor of the upper limb comprising the administration of a botulinum neurotoxin to at least one muscle of the forearm/wrist, elbow and shoulder, wherein the botulinum neurotoxin is administered to at least one muscle of the forearm/wrist selected from the group of M. extensor carpi ulnaris (ECU), M. extensor carpi radialis (ECR), M. pronator quadratus (PQ) and M. supinator in a dosage in the range of 2 to 6 U and wherein the botulinum neurotoxin is administered to at least one muscle of the elbow in a dosage of about 20 U and to at least one muscle of the shoulder in a dosage of about 15 U.
This invention relates to novel uses of botulinum neurotoxin in treating a tremor, in particular to a botulinum neurotoxin for use in treating a tremor of the upper limb comprising the administration of a botulinum neurotoxin to at least one muscle of the forearm/wrist, elbow and shoulder, wherein the botulinum neurotoxin is administered to at least one muscle of the forearm/wrist selected from the group of M. extensor carpi ulnaris (ECU), M. extensor carpi radialis (ECR), M. pronator quadratus (PQ) and M. supinator in a dosage in the range of 2 to 6 U and wherein the botulinum neurotoxin is administered to at least one muscle of the elbow in a dosage of about 20 U and to at least one muscle of the shoulder in a dosage of about 15 U.
The present invention relates to a modified hyaluronic acid derivative, wherein the -CH2-OH group of at least one N-acetyl-D-glucosamine unit is modified into an aldehyde group having the structure -CH2-O-CH2-CHO, methods for preparing same and applications thereof.
03 - Produits cosmétiques et préparations de toilette; préparations pour blanchir, nettoyer, polir et abraser.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Cosmetics; shampoos. Dietary supplements and dietetic preparations; medicinal
hair growth preparations; dietetic foods adapted for medical
purposes; nutritional supplements; dietetic food
preparations adapted for medical use; medical preparations;
pharmaceutical preparations and substances; pharmaceutical
preparations.
03 - Produits cosmétiques et préparations de toilette; préparations pour blanchir, nettoyer, polir et abraser.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Cosmetics; shampoos. Dietary supplements and dietetic preparations; medicinal
hair growth preparations; dietetic foods adapted for medical
purposes; nutritional supplements; dietetic food
preparations adapted for medical use; medical preparations;
pharmaceutical preparations; pharmaceutical preparations and
substances.
90.
Mixing nozzle, application device, kit and method using the mixing nozzle or application device
The present invention generally relates to a mixing nozzle (12) for mixing at least two liquid compositions such as a first liquid composition and a second liquid composition. The mixing nozzle (10) is configured to be coupled to a body (11) of a multi-component application device (10), in particular to a body (11) of a two-component syringe assembly, for injection of a liquid composition, which body (11) is configured to separately store said at least two solutions. The present invention further relates to a multi-component application device (10) comprising said mixing nozzle (12) and to a kit comprising said mixing nozzle (12) or said application device (10). Furthermore, the present invention relates to a method using said application device or said kit, for example for replacing or filling a biological tissue or increasing the volume of a biological tissue.
03 - Produits cosmétiques et préparations de toilette; préparations pour blanchir, nettoyer, polir et abraser.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Cosmetics; salves [non medicated]; beauty masks; skin
lotions; face creams for cosmetic use; balms, other than for
medical purposes; moisturizing creams; hydrating creams for
cosmetic use, serum for cosmetic purposes. Pharmaceutical preparations; pharmaceuticals; pharmaceutical
drugs; injectable dermal fillers. Medical consultations; beauty consultations; consultancy in
the field of body and beauty care; beauty consultancy; human
hygiene and beauty care; application of cosmetic products to
the face; medical analysis services relating to the
treatment of persons; information services relating to
health care; consultancy and information services relating
to pharmaceutical products; services for the care of the
skin; providing information about beauty; medical
counseling; advisory services relating to beauty treatment;
consultancy services relating to beauty; advisory services
relating to medical services.
03 - Produits cosmétiques et préparations de toilette; préparations pour blanchir, nettoyer, polir et abraser.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
(1) Cosmetics; shampoos.
(2) Medical preparations, namely medicinal hair growth preparations, medicinal preparations for the treatment of hair loss, for stimulating hair growth, for improving hair health and beauty, and for improving nails health and beauty; pharmaceutical preparations for the treatment of hair loss, for stimulating hair growth, for improving hair health and beauty, and for improving nails health and beauty.
03 - Produits cosmétiques et préparations de toilette; préparations pour blanchir, nettoyer, polir et abraser.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Cosmetics; shampoos Dietary supplements and dietetic preparations adapted for medical purposes; medicinal hair growth preparations; dietetic foods adapted for medical purposes; nutritional supplements; dietetic food preparations adapted for medical use; medical preparations for hair and nail growth; pharmaceutical preparations for hair and nail growth; pharmaceutical preparations and substances for hair and nail growth
94.
Recombinant clostridial neurotoxins with increased duration of effect
This invention relates to novel recombinant clostridial neurotoxins exhibiting increased duration of effect and to methods for the manufacture of such recombinant clostridial neurotoxins. These novel recombinant clostridial neurotoxins comprise a random coil domain, and the methods comprise the steps of inserting a nucleic acid sequence coding for a random coil domain into a nucleic acid sequence coding for a parental clostridial neurotoxin and expression of the recombinant nucleic acid sequence comprising the random coil domain-coding sequence in a host cell. The invention further relates to novel recombinant single-chain precursor clostridial neurotoxins used in such methods, nucleic acid sequences encoding such recombinant single-chain precursor clostridial neurotoxins, and pharmaceutical compositions comprising the recombinant clostridial neurotoxin with increased duration of effect.
A61K 38/16 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés
C07K 14/33 - Peptides ayant plus de 20 amino-acides; Gastrines; Somatostatines; Mélanotropines; Leurs dérivés provenant de bactéries provenant de Clostridium (G)
C12N 15/52 - Gènes codant pour des enzymes ou des proenzymes
C12N 15/70 - Vecteurs ou systèmes d'expression spécialement adaptés à E. coli
A61K 38/00 - Préparations médicinales contenant des peptides
95.
Recombinant botulinum neurotoxins with increased duration of effect
This invention relates to novel recombinant botulinum neurotoxins serotype A exhibiting both (i) an increased duration of effect and (ii) a high specific biological activity. These novel recombinant botulinum neurotoxins comprise at least two additional domains consisting of proline, alanine and an additional amino acid residue and at least one amino acid modification which is located at the alpha-exosite or at the beta-exosite of the light chain of the neurotoxin. The invention further relates to novel recombinant single-chain precursor botulinum neurotoxins and compositions comprising the recombinant botulinum neurotoxin with an increased duration of effect and a high specific biological activity.
The present invention relates to a prefilled glass container, such as a prefilled glass syringe, comprising an aqueous botulinum toxin formulation. The aqueous botulinum toxin formulation in the prefilled container is stable at low to ambient temperature for a prolonged time period. Furthermore, the present invention relates to a kit comprising the botulinum toxin prefilled container, and to the use of the botulinum toxin prefilled container in therapeutic and cosmetic applications.
A61Q 19/08 - Préparations contre le vieillissement
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61M 5/315 - Pistons; Tiges de piston; Guidage, blocage, ou limitation des mouvements de la tige; Accessoires disposés sur la tige pour faciliter le dosage
A61K 47/26 - Hydrates de carbone, p.ex. polyols ou sucres alcoolisés, sucres aminés, acides nucléiques, mono-, di- ou oligosaccharides; Leurs dérivés, p.ex. polysorbates, esters d’acide gras de sorbitan ou glycyrrhizine
A61K 47/42 - Protéines; Polypeptides; Leurs produits de dégradation; Leurs dérivés p.ex. albumine, gélatine ou zéine
The present invention relates to a vial that is at least partially filled with an aqueous formulation of a neurotoxin, preferably botulinum toxin, to the manufacture of the vial and to the use thereof.The aqueous formulation of a neurotoxin is stable in the vial for a prolonged period of time.
A61J 1/14 - Récipients spécialement adaptés à des fins médicales ou pharmaceutiques - Détails; Accessoires à cet effet
B32B 27/08 - Produits stratifiés composés essentiellement de résine synthétique comme seul composant ou composant principal d'une couche adjacente à une autre couche d'une substance spécifique d'une résine synthétique d'une sorte différente
B32B 27/32 - Produits stratifiés composés essentiellement de résine synthétique comprenant des polyoléfines
This invention relates to novel uses of botulinum neurotoxin in treating a disease or condition associated with lipoedema, in particular uses of botulinum neurotoxin in treating pain associated with lipoedema.
Medical and veterinary apparatus and instruments; Clothing, headgear and footwear for medical personnel and patients.; Clothing, headgear and footwear, braces and supports, for medical purposes; Prosthetics and artificial implants; Mobility aids; Physical therapy equipment; Orthopaedic soles; Orthopaedic detachable insoles. Inner soles; Insoles [for shoes and boots]; Parts of clothing, footwear and headgear.
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Books in the field of medicine and aesthetic dermatology; printed matter, namely, newsletters, magazines, pamphlets, and written articles in the field of medicine and aesthetics dermatology; printed instructional and teaching material in the field of medicine and aesthetic dermatology; copy paper and stationery; printed periodicals in the field of medicine and aesthetic dermatology; magazines featuring medicine and aesthetic dermatology; newspapers; all the foregoing excluding the fields of toxicology, toxic substances and hazardous waste Online advertising services for others; advertising services in the field of medicine, cosmetic surgery, beauty, and aesthetic dermatology; advertising services for goods and services via websites; advertising, namely, online-advertisements via a global computer network; all the foregoing excluding the fields of toxicology, toxic substances and hazardous waste Training seminars in the field of pharmaceuticals; medical training and teaching; vocational education services in the field of medicine and aesthetic dermatology; vocational education in the field of medicine for medical personnel; vocational education services in the field of cosmetics; providing online, non-downloadable publications in the nature of newsletters, magazines, pamphlets, specialized journals, and articles in the field of medicine and aesthetic dermatology; providing non-downloadable electronic publications in the nature of blogs and articles in the field of medicine and aesthetic dermatology; arranging, conducting, and organization of educational seminars, classes, workshops, and colloquiums in the field of aesthetic dermatology; organization of educational seminars and classes in the field of medicine; publishing and issuing of scientific papers in the field of medicine; publication of printed matter, books, and magazines; providing online non-downloadable electronic publications in the nature of newsletters, magazines, pamphlets, and articles in the field of medicine, cosmetic surgery, beauty, and aesthetic dermatology; all the foregoing excluding the fields of toxicology, toxic substances and hazardous waste Scientific research in the medical field; medical research and development of pharmaceuticals and cosmetics; medical research; medical and pharmaceutical research services; pharmaceutical research and development; scientific research and development; computer technological services, namely, providing a website featuring an on-line, non-downloadable, software application for connecting users to databases which provide scientific and technical information on aesthetic dermatology and medicine, excluding databases in the fields of toxicology, toxic substances and hazardous waste; all the foregoing excluding the fields of toxicology, toxic substances and hazardous waste
