Abrégé

A vibratory stimulation apparatus and a vibratory stimulation method are provided. The vibratory stimulation apparatus includes at least one vibration generator configured to apply a vibration to an agonist muscle of a body of a user to thereby apply a stimulation to an antagonist muscle that forms a pair with the agonist muscle. The vibratory stimulation method includes applying a vibration to an agonist muscle of the body of a user to thereby apply the stimulation to an antagonist muscle that forms a pair with the agonist muscle.

Classes IPC  ?

• A61H 23/00 - Massage par percussion ou vibration, p. ex. en utilisant une vibration ultrasoniqueMassage par succion-vibrationMassage avec des membranes mobiles
• A61H 23/02 - Massage par percussion ou vibration, p. ex. en utilisant une vibration ultrasoniqueMassage par succion-vibrationMassage avec des membranes mobiles à entraînement électrique ou magnétique

Abrégé

Provided is a diamond laminate that exhibits an excellent electron emission capability and can form an electrode reaction field with an excellent reducing property. The laminate of the present disclosure includes an electron excitation layer (1) having a diamond crystal structure in which some carbon atoms are substituted with nitrogen atoms, and a conductive layer (2) having a diamond crystal structure in which some carbon atoms are substituted with boron atoms. The nitrogen atom concentration in the layer (1) is preferably 5×1018 atoms/cm3 or greater, and the boron atom concentration in the layer (2) is preferably 1×1019 atoms/cm3 or greater. The thickness of the layer (1) is preferably from 1 nm to 100 μm, and the thickness of the layer (2) is preferably 1 μm or greater.

Classes IPC  ?

• C25B 11/043 - Carbone, p. ex. diamant ou graphène
• C25B 1/23 - Oxyde de carbone ou gaz de synthèse

Abrégé

[Problem] To provide a gas concentration device capable of continuously supplying oxygen-enriched air having a high oxygen concentration by enabling an adsorbent to demonstrate adsorption capacity with high efficiency. [Solution] An adsorption rotor including an adsorbent that preferentially adsorbs oxygen over nitrogen is divided into at least a treatment zone, a regeneration zone, and a purge zone and is configured such that the zones rotate in sequence in the stated order. Raw material air is passed through the treatment zone so that oxygen is adsorbed on the adsorbent. The air that has passed through the treatment zone is sent to a supply destination or is discharged to the atmosphere. Heated air that has passed through a regeneration heater is passed through the regeneration zone to desorb oxygen adsorbed on the adsorbent, and part of the air that has passed through the regeneration zone is taken out as oxygen-enriched air. The rest is returned to the inlet side of the regeneration heater for regeneration circulation. Air is passed through the purge zone to purge the oxygen-enriched air remaining in the adsorption rotor.

Classes IPC  ?

• C01B 13/02 - Préparation de l'oxygène
• B01D 53/06 - Séparation de gaz ou de vapeursRécupération de vapeurs de solvants volatils dans les gazÉpuration chimique ou biologique des gaz résiduaires, p. ex. gaz d'échappement des moteurs à combustion, fumées, vapeurs, gaz de combustion ou aérosols par adsorption, p. ex. chromatographie préparatoire en phase gazeuse avec adsorbants mobiles
• B01D 53/62 - Oxydes de carbone
• C01B 32/50 - Anhydride carbonique

Abrégé

The present invention provides a method of detecting a biomarker for detecting hepatocytes with bile ductular proliferation, the method including: detecting laminin γ2 single chain or a nucleic acid encoding the same as the biomarker in a specimen.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

A cell quality evaluation device comprising: a reception unit that receives a cell image; a contour extraction unit that extracts the contour of a cell included in the cell image received by the reception unit; a force information derivation unit that derives force information for the cell on the basis of the contour of the cell extracted by the contour extraction unit; a shape information derivation unit that derives shape information for the cell on the basis of the contour of the cell extracted by the contour extraction unit; and a quality evaluation unit that evaluates the quality of the cell on the basis of the shape information for the cell derived by the shape information derivation unit and the force information for the cell derived by the force information derivation unit.

Classes IPC  ?

• C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
• G01N 33/48 - Matériau biologique, p. ex. sang, urineHémocytomètres
• G01N 33/483 - Analyse physique de matériau biologique

Abrégé

The present invention addresses the problem of providing a prophylactic and/or therapeutic agent for hypertensive disorders of pregnancy, which has a physical property or a molecular weight that inhibits the passage through the placental barrier, has a pharmacological activity that mimics the original physiological function of the placenta and therefore has fewer adverse side effects, is safe for a mother body and a fetus, is stable for a long period, and can exert the efficacy thereof in vivo for a long period.　The present invention is a prophylactic/therapeutic agent for pregnancy-induced hypertension, which contains aminopeptidase A (APA) as an active ingredient, the prophylactic/therapeutic agent being characterized in that the APA is bound to an immunoglobulin Fc region through a peptide linker.

Classes IPC  ?

• A61K 47/68 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un anticorps, une immunoglobuline ou son fragment, p. ex. un fragment Fc
• A61K 38/48 - Hydrolases (3) agissant sur des liaisons peptidiques (3.4)
• A61K 47/65 - Séquences de liaison, liants ou bras-espaceurs peptidiques, p. ex. séquences de liaison peptidiques vulnérable aux protéases
• A61P 9/12 - Antihypertenseurs
• C07K 7/06 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 5 à 11 amino-acides
• C07K 7/08 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 12 à 20 amino-acides
• C07K 16/00 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux
• C07K 19/00 - Peptides hybrides
• C12N 9/50 - Protéinases
• C12N 15/13 - Immunoglobulines
• C12N 15/57 - Hydrolases (3) agissant sur les liaisons peptidiques (3.4)
• C12N 15/62 - Séquences d'ADN codant pour des protéines de fusion

Abrégé

The objective of the present invention is to provide an amide-modified cellulose ether produced by a simple method, and an amide-modified cellulose ether using an aromatic amide.　Provided is a cellulose derivative having a repeating unit represented by formula (1), wherein the total average degree of substitution of a protecting group for a hydroxyl group, a group represented by specific formula (1-a), and a group represented by specific formula (1-b) is 1.5 or more.

Classes IPC  ?

• C08B 11/15 - Alkyl ou cycloalkyléthers à radicaux hydrocarbonés substitués à groupes azotés à groupes carbamoyle

Abrégé

The objective of the present invention is to provide an amide-modified cellulose ether produced by a simple method, and an amide-modified cellulose ether using an aromatic amide.　Provided is a cellulose derivative having a repeating unit represented by formula (1), wherein the total average degree of substitution of a protecting group for a hydroxyl group, a group represented by specific formula (1-a), and a group represented by specific formula (1-b) is 1.5 or more.

Classes IPC  ?

• C08B 13/00 - Préparation d'éthers-esters cellulosiques
• C08B 11/15 - Alkyl ou cycloalkyléthers à radicaux hydrocarbonés substitués à groupes azotés à groupes carbamoyle

Abrégé

Provided is a polynucleotide comprising at least one sequence encoding a fusion protein comprising (a) an antigen-presenting MHC molecule, which can be presented outside the membrane of a cell or an extracellular vesicle; (b) at least one T-cell stimulatory cytokine or subunit thereof, which can be presented outside the membrane of a cell or an extracellular vesicle; (c) a T-cell costimulatory molecule, which can be presented outside the membrane of a cell or an extracellular vesicle; (d) an antigen-presenting MHC molecule and at least one T-cell stimulatory cytokine or subunit thereof, which can be presented outside the membrane of a cell or an extracellular vesicle; or (e) an antigen-presenting MHC molecule, at least one T-cell stimulatory cytokine p or subunit thereof, and a T-cell costimulatory molecule, which can be presented outside the membrane of a cell or an extracellular vesicle.

Classes IPC  ?

• C07K 14/74 - Complexe majeur d'histocompatibilité [MHC]
• A61K 38/00 - Préparations médicinales contenant des peptides
• A61P 35/00 - Agents anticancéreux
• C07K 14/495 - Facteur de croissance transformant [TGF]
• C07K 14/54 - Interleukines [IL]
• C07K 14/55 - IL-2
• C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire

Abrégé

An object of the present disclosure is to provide a method for producing a polysaccharide nanofiber-blended polysaccharide composition whose mechanical physical properties are reinforced by a polysaccharide nanofiber, and is easily carried out. A method for producing a polysaccharide nanofiber-blended polysaccharide composition is also provided which includes a step of mixing a sol containing a polysaccharide nanofiber (A), a polysaccharide (B), and a solvent (C) capable of dissolving the polysaccharide (B), and a step of drying the resultant mixture to obtain a dry mixture.

Classes IPC  ?

• C08L 1/12 - Acétate de cellulose
• C08J 5/04 - Renforcement des composés macromoléculaires avec des matériaux fibreux en vrac ou en nappes
• C08L 3/02 - AmidonSes produits de dégradation, p. ex. dextrine
• C08L 5/00 - Compositions contenant des polysaccharides ou leurs dérivés non prévus dans les groupes ou
• C08L 5/08 - ChitineSulfate de chondroïtineAcide hyaluroniqueLeurs dérivés

Abrégé

The present invention provides a reduction device that can be inexpensively and easily produced, that has a wide reaction field, that can achieve a reduction reaction even with low energy light rays of visible light, and that has a long catalyst life.　A reduction device according to the present disclosure is characterized by comprising diamond particles. The diamond particles are preferably contained in the form of a diamond particle dispersion. The diamond particles preferably include nanodiamond particles having a particle size of not more than 1 μm. The diamond particles preferably include detonation method nanodiamond particles.

Classes IPC  ?

• B01J 19/12 - Procédés utilisant l'application directe de l'énergie ondulatoire ou électrique, ou un rayonnement particulaireAppareils à cet usage utilisant des radiations électromagnétiques
• B01J 21/18 - Carbone
• B01J 35/39 - Propriétés photocatalytiques
• C01B 3/04 - Production d'hydrogène ou de mélanges gazeux contenant de l'hydrogène par décomposition de composés inorganiques, p. ex. de l'ammoniac
• C01B 32/40 - Oxyde de carbone

Abrégé

Provided is a semiconductor catalyst that exhibits an effect of promoting a reduction reaction by visible light irradiation and has excellent durability.　A semiconductor catalyst according to the present disclosure comprises a thin film that contains nitrogen-containing diamond particles in the surface direction and the height direction.　The semiconductor catalyst can be manufactured, for example, by performing step 1, and then performing step 2 at least once. Step 1: a step for immobilizing, on a substrate having a positive or negative charge, nitrogen-containing diamond particles which have a positive or negative charge and have a charge opposite to the charge of the substrate, Step 2: a step for laminating, on the immobilized nitrogen-containing diamond particles, nitrogen-containing diamond particles which have a positive or negative charge and have a charge opposite to the charge of the immobilized nitrogen-containing diamond particles.

Classes IPC  ?

• B01J 21/18 - Carbone
• B01J 27/24 - Composés de l'azote
• B01J 35/39 - Propriétés photocatalytiques
• B01J 35/54 - Bâtonnets ou plaquettes
• B01J 37/02 - Imprégnation, revêtement ou précipitation
• C01B 3/04 - Production d'hydrogène ou de mélanges gazeux contenant de l'hydrogène par décomposition de composés inorganiques, p. ex. de l'ammoniac
• C01B 32/26 - Préparation
• C25B 1/04 - Hydrogène ou oxygène par électrolyse de l'eau
• C25B 1/55 - Photo-électrolyse
• C25B 9/00 - Cellules ou assemblages de cellulesÉléments de structure des cellulesAssemblages d'éléments de structure, p. ex. assemblages d'électrode-diaphragmeCaractéristiques des cellules relatives aux procédés
• C25B 9/50 - Cellules ou assemblages de cellules comprenant des photo-électrodesAssemblages de leurs éléments de structure
• C25B 11/043 - Carbone, p. ex. diamant ou graphène
• C25B 11/049 - Photo-catalyseurs
• C25B 11/052 - Électrodes comportant un substrat et un ou plusieurs revêtements électro-catalytiques
• C25B 11/083 - Diamant
• C25B 11/087 - Composé photo-catalytique

Abrégé

The present invention accurately infers the presence or absence of a disease. An information processing device (1A) comprises: an image acquisition unit (11) that acquires an image that has captured therein a target site of a subject to which a radiopharmaceutical has been administered; a variation index calculation unit (51) that calculates, on the basis of the image, a variation index (23) indicating the degree of variation in radiation dose at the target site, the radiation dose being emitted from the radiopharmaceutical accumulated in the target site of the subject; and an inference unit (12) that infers a disease at the target site of the subject on the basis of the calculated variation index (23).

Classes IPC  ?

• G01T 1/161 - Applications au domaine de la médecine nucléaire, p. ex. comptage in vivo
• G06T 7/00 - Analyse d'image

Abrégé

A fuel cell system includes a fuel cell, an electric power recovery device, and a control device that controls the fuel cell and the electric power recovery device. In a state where supplying of the liquid fuel to the fuel cell is stopped, the control device charges post-stop electric power generated by the fuel cell using the liquid fuel that has been already supplied, thereby recovering the post-stop electric power into the electric power recovery device, and thereafter stopping an electrode reaction in an electrode structure of the fuel cell.

Classes IPC  ?

• H01M 8/04858 - Variables électriques
• H01M 8/04223 - Dispositions auxiliaires, p. ex. pour la commande de la pression ou pour la circulation des fluides pendant le démarrage ou l’arrêtDépolarisation ou activation, p. ex. purgeMoyens pour court-circuiter les éléments à combustible défectueux
• H01M 8/04228 - Dispositions auxiliaires, p. ex. pour la commande de la pression ou pour la circulation des fluides pendant le démarrage ou l’arrêtDépolarisation ou activation, p. ex. purgeMoyens pour court-circuiter les éléments à combustible défectueux pendant l’arrêt
• H01M 8/04303 - Procédés de commande des éléments à combustible ou des systèmes d’éléments à combustible appliqués pendant des périodes spécifiques appliqués pendant l’arrêt
• H01M 8/04537 - Variables électriques
• H01M 8/04746 - PressionDébit
• H01M 8/04955 - Extinction ou arrêt des éléments à combustible
• H01M 16/00 - Combinaisons structurelles de différents types de générateurs électrochimiques

Abrégé

[Problem] The purpose of the present invention is to provide a nickel substrate for obtaining a large diameter diamond substrate, and to provide a method for manufacturing a diamond substrate using the nickel substrate. [Solution] This nickel substrate is to be used for the heteroepitaxial growth of a diamond layer, and is characterized in that the nickel substrate is formed of single crystals, and has a (111) crystal surface on the surface thereof.

Classes IPC  ?

• C30B 29/04 - Diamant
• C23C 16/02 - Pré-traitement du matériau à revêtir
• C23C 16/27 - Le diamant uniquement
• H01L 21/205 - Dépôt de matériaux semi-conducteurs sur un substrat, p. ex. croissance épitaxiale en utilisant la réduction ou la décomposition d'un composé gazeux donnant un condensat solide, c.-à-d. un dépôt chimique

Abrégé

The present invention provides a composition for regulating carbohydrate metabolism, the composition containing, as an active ingredient, an agent for controlling the amount of D-amino acid in the living body of a subject. Moreover, the present invention provides a method for assessing carbohydrate metabolism conditions of a subject by monitoring the amount of D-amino acid in the living body of the subject.

Classes IPC  ?

• A61K 31/198 - Alpha-amino-acides, p. ex. alanine ou acide édétique [EDTA]
• A61K 31/519 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime condensées en ortho ou en péri avec des hétérocycles
• A61P 3/10 - Médicaments pour le traitement des troubles du métabolisme de l'homéostase du glucose de l'hyperglycémie, p. ex. antidiabétiques

Abrégé

A kneading state detection device includes an acquisition unit that, when an extrusion molding machine that kneads a raw material or kneads a raw material and an additive is in operation, acquires an output of an AE sensor installed on a housing of the extrusion molding machine, and a determination unit that determines a kneading state of the raw material, based on a comparison between a change in intensity of the output of the AE sensor acquired by the acquisition unit and a threshold.

Classes IPC  ?

• B29B 7/72 - Mesure, commande ou régulation
• B29B 7/48 - MélangeMalaxage continu, avec dispositifs mécaniques de mélange ou de malaxage avec dispositifs de mélange ou de malaxage mobiles rotatifs avec plus d'un arbre à dispositifs à engrènement, p. ex. à vis qui s'engrènent
• G01N 29/14 - Recherche ou analyse des matériaux par l'emploi d'ondes ultrasonores, sonores ou infrasonoresVisualisation de l'intérieur d'objets par transmission d'ondes ultrasonores ou sonores à travers l'objet utilisant des techniques d'émission acoustique
• G01N 29/44 - Traitement du signal de réponse détecté
• G01N 29/46 - Traitement du signal de réponse détecté par analyse spectrale, p. ex. par analyse de Fourier

Abrégé

There is provided a cellulose derivative that has a high amount of a chelate adsorption group introduced, has high hydrophilicity, and is capable of efficiently recovering boron. There is provided a cellulose derivative that has a high amount of a chelate adsorption group introduced, has high hydrophilicity, and is capable of efficiently recovering boron. The cellulose derivative of the present disclosure has a repeating unit represented by the following formula (1-1). In the following formula (I-1), Ra is the same as or different from each other, and is a hydroxyl group or a group represented by the following formula (a). In the following formula (a), R1 represents a hydrogen atom or a methyl group. R2 represents a hydrogen atom or a hydrocarbon group optionally having a hydroxyl group. R3 represents a hydrogen atom or a hydrocarbon group. Note that at least one of all R3 contained in the cellulose derivative is the group represented by the following formula (a). There is provided a cellulose derivative that has a high amount of a chelate adsorption group introduced, has high hydrophilicity, and is capable of efficiently recovering boron. The cellulose derivative of the present disclosure has a repeating unit represented by the following formula (1-1). In the following formula (I-1), Ra is the same as or different from each other, and is a hydroxyl group or a group represented by the following formula (a). In the following formula (a), R1 represents a hydrogen atom or a methyl group. R2 represents a hydrogen atom or a hydrocarbon group optionally having a hydroxyl group. R3 represents a hydrogen atom or a hydrocarbon group. Note that at least one of all R3 contained in the cellulose derivative is the group represented by the following formula (a).

Classes IPC  ?

• B01J 20/24 - Composés macromoléculaires d'origine naturelle, p. ex. acides humiques ou leurs dérivés
• B01J 20/28 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtrationAbsorbants ou adsorbants pour la chromatographieProcédés pour leur préparation, régénération ou réactivation caractérisées par leur forme ou leurs propriétés physiques

Abrégé

Provided is a technology that enables liquid plasma treatment of a substrate surface at low power.　A plasma treatment device (10) comprises: a chamber (20) that stores a liquid Lq; a substrate holder (50) that holds a substrate Wf while the substrate is disposed in the liquid; a gas chamber (60) which accommodates a gas Ga, which has an opening (64) in an area opposing the substrate, and in which at least the opening is disposed inside the liquid of the chamber and is spaced apart from the substrate; a microwave generation device (80) that generates microwaves; a waveguide (82) that has a prescribed area (84) disposed inside the gas chamber and that transmits, to the prescribed area, the microwaves generated by the microwave generation device; and an antenna (90) that is disposed in the prescribed area of the waveguide and that induces plasma by projecting the microwaves into the gas chamber.

Classes IPC  ?

• H05H 1/30 - Torches à plasma utilisant des champs électromagnétiques appliqués, p. ex. de l'énergie à haute fréquence ou sous forme de micro-ondes
• H01L 21/304 - Traitement mécanique, p. ex. meulage, polissage, coupe
• H05H 1/24 - Production du plasma

Abrégé

A track generation device generates a track of a fluid discharge unit that discharges a fluid for applying the fluid to a surface of an object along a target application track. The track generation device includes a storage unit and a track generation unit. The storage unit stores a time-series model indicating a relationship between the track of the fluid discharge unit and an application track of the fluid in consideration of behavior of the fluid due to a viscosity, and the relationship is learned based on an actual track of the fluid discharge unit and an actual application track of the fluid. The track generation unit is configured to generate the track of the fluid discharge unit corresponding to the target application track using the time-series model upon reception of the target application track.

Classes IPC  ?

• B05C 11/10 - Stockage, débit ou réglage du liquide ou d'un autre matériau fluideRécupération de l'excès de liquide ou d'un autre matériau fluide
• B05C 5/02 - Appareillages dans lesquels un liquide ou autre matériau fluide est projeté, versé ou répandu sur la surface de l'ouvrage à partir d'un dispositif de sortie en contact, ou presque en contact, avec l'ouvrage

Abrégé

An acetabulum-reinforcing implant (1) according to one embodiment comprises: a dome section (2) which includes a vertical frame and a horizontal frame which intersect one another and curve along a spherical surface which corresponds to the acetabulum (92); a flat pallet section (3) which is screwed to the ilium (91) and is folded upward from the vertical frame; and a hook section (4) which engages the obturator foramen and extends downward from the vertical frame. When the acetabulum-reinforcing implant (1) is attached to the pelvis (9), the hook section (4) is inclined relative to the vertical frame toward the front of the pelvis (9) and twists increasingly more toward the front of the pelvis (9) relative to the vertical frame in the medial direction of the pelvis (9), in a manner such that the pallet section (3) intersects the mediolateral direction of the pelvis (9) and a vertical axis (1A), which is a projection of the center line (21a) of the vertical frame (21) onto a plane extending along the pallet section (3), is parallel to the pelvic plane.

Classes IPC  ?

• A61F 2/34 - Coques acétabulaires

Abrégé

The present invention provides a novel substance that suitably functions as an Met agonist. The present invention provides an artificial protein that includes an antibody Fc region, where an amino acid represented by SEQ ID NO: 1 is inserted into the Fc region (in SEQ ID NO: 1, X1, X2, X3, X4, X5, X6, X7, X8, X9, X10, and X11each independently represents an amino acid, and n1 and n2 are each independently an integer from 0 to 6).　(X1n1n1YX3X4FYYNYX 5X6X7WX8X9X10X11(X2n2n2 (SEQ ID NO: 1)

Classes IPC  ?

• C07K 19/00 - Peptides hybrides
• A61K 38/00 - Préparations médicinales contenant des peptides
• A61K 47/68 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un anticorps, une immunoglobuline ou son fragment, p. ex. un fragment Fc
• A61P 1/16 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif des troubles de la vésicule biliaire ou du foie, p. ex. protecteurs hépatiques, cholagogues, cholélitholytiques
• A61P 3/06 - Antihyperlipémiants
• A61P 9/00 - Médicaments pour le traitement des troubles du système cardiovasculaire
• A61P 9/10 - Médicaments pour le traitement des troubles du système cardiovasculaire des maladies ischémiques ou athéroscléreuses, p. ex. médicaments antiangineux, vasodilatateurs coronariens, médicaments pour le traitement de l'infarctus du myocarde, de la rétinopathie, de l'insuffisance cérébro-vasculaire, de l'artériosclérose rénale
• A61P 9/14 - VasoprotecteursAntihémorroïdauxMédicaments pour le traitement des varicesStabilisateurs capillaires
• A61P 11/00 - Médicaments pour le traitement des troubles du système respiratoire
• A61P 11/06 - Antiasthmatiques
• A61P 13/12 - Médicaments pour le traitement des troubles du système urinaire des reins
• A61P 17/00 - Médicaments pour le traitement des troubles dermatologiques
• A61P 21/00 - Médicaments pour le traitement des troubles du système musculaire ou neuromusculaire
• A61P 37/06 - Immunosuppresseurs, p. ex. médicaments pour le traitement du rejet de greffe
• C07K 7/08 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 12 à 20 amino-acides
• C07K 16/00 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux

Abrégé

This method for producing a fiber-reinforced composite material includes: a fiber dispersion process of providing a fiber-dispersed resin by kneading a resin 10a with fibers 10b to disperse the fibers 10b in the resin 10a; and a molecular weight reduction process in which, while transporting the fiber-dispersed resin along an outer peripheral surface of a screw body 37 provided with a passage 88 inside, the fiber-dispersed resin passes from an inlet 91 of the passage 88 to an outlet 92 of the passage 88 and a shear force is applied to the fiber-dispersed resin by restricting the transport of the fiber-dispersed resin with a barrier unit 82 disposed between the inlet 91 and the outlet 92 of the passage 88 on the outer peripheral surface.

Classes IPC  ?

• B29B 7/90 - Charges ou agents de renforcements
• B29B 7/42 - MélangeMalaxage continu, avec dispositifs mécaniques de mélange ou de malaxage avec dispositifs de mélange ou de malaxage mobiles rotatifs avec un seul arbre à vis ou à vis sans fin
• B29C 70/06 - Façonnage de matières composites, c.-à-d. de matières plastiques comprenant des renforcements, des matières de remplissage ou des parties préformées, p. ex. des inserts comprenant uniquement des renforcements, p. ex. matières plastiques auto-renforçantes des renforcements fibreux uniquement

Abrégé

A production device for melt-blown non-woven fabric, with which a high molecular weight polymer can be reduced in molecular weight by applying a shear force to the high molecular weight polymer without adding an additive such as a peroxide that promotes thermal decomposition reaction, and a low molecular weight polymer can be efficiently produced. The low molecular weight polymer and the melt-blown non-woven fabric are produced using a continuous high shearing device that applies a shear force to the high molecular weight polymer serving as a raw material by rotation of a screw body 37 to reduce the molecular weight of the high molecular weight polymer so as to obtain a low molecular weight polymer, and cools the low molecular weight polymer by passing the low molecular weight polymer through a passage 88 arranged in the axial direction inside the screw body 37.

Classes IPC  ?

• D04H 1/56 - Non-tissés formés uniquement ou principalement de fibres coupées ou autres fibres similaires relativement courtes à partir de voiles ou couches composés de fibres ne possédant pas des propriétés cohésives réelles ou potentielles par soudage des fibres ensembles, p. ex. par fusion partielle ou dissolution en association avec la formation de la fibre, p. ex. suivant immédiatement l'extrusion des fibres en brin
• B29C 48/88 - Traitement thermique de l’écoulement de matière extrudée, p. ex. refroidissement
• B29C 48/86 - Traitement thermique de la matière à mouler par extrusion ou des pièces ou des couches préformées, p. ex. par chauffage ou refroidissement dans la zone de la filière
• B29C 48/30 - Filières ou matrices d’extrusion
• B29C 48/05 - Moulage par extrusion, c.-à-d. en exprimant la matière à mouler dans une matrice ou une filière qui lui donne la forme désiréeAppareils à cet effet caractérisées par la forme à l’extrusion de la matière extrudée filamentaire, p. ex. fils
• B29C 48/285 - Alimentation de l’extrudeuse en matière d’extrusion
• B29B 7/48 - MélangeMalaxage continu, avec dispositifs mécaniques de mélange ou de malaxage avec dispositifs de mélange ou de malaxage mobiles rotatifs avec plus d'un arbre à dispositifs à engrènement, p. ex. à vis qui s'engrènent
• B29B 7/72 - Mesure, commande ou régulation
• B29B 7/82 - Chauffage ou refroidissement
• D04H 1/4291 - Famille des oléfines

Abrégé

The present invention relates to a BODIPY compound, and a temperature-sensitive fluorescent sensor of cell organelles comprising same. A BODIPY compound according to one aspect can quickly detect minute temperature changes with high sensitivity and accurately target various cell organelles, and has no cytotoxicity. That is, the BODIPY compound according to one aspect can visualize the temperature for each cell organelle and is expected to be useful as a temperature-sensitive fluorescent sensor of cell organelles.

Classes IPC  ?

• C07F 5/02 - Composés du bore
• G01K 11/20 - Mesure de la température basée sur les variations physiques ou chimiques, n'entrant pas dans les groupes , , ou utilisant des matériaux thermo-luminescents
• G01K 11/16 - Mesure de la température basée sur les variations physiques ou chimiques, n'entrant pas dans les groupes , , ou utilisant le changement de couleur, de translucidité ou de réflectance de matériaux organiques

Abrégé

Provided are a novel complex having the effect of efficiently adsorbing and collecting arsenic(V) dissolved in water, and a novel arsenic adsorbent. The complex has a structure in which metal particles including zero-valent and/or trivalent iron are supported on a microfibrous cellulose surface. The metal particles of the complex contain at least one type of metal oxide, hydroxide or oxyhydroxide selected from zirconium and titanium, together with zero-valent and/or trivalent iron. The molar ratio [iron/(zirconium + titanium)] of iron (elementary iron equivalent) and the metal oxide, hydroxide and oxyhydroxide (elementary metal equivalent; total amount when containing two or more compounds) is preferably 1 to 100. The arsenic adsorbent contains the complex.

Classes IPC  ?

• B01J 20/02 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtrationAbsorbants ou adsorbants pour la chromatographieProcédés pour leur préparation, régénération ou réactivation contenant une substance inorganique
• B01J 20/30 - Procédés de préparation, de régénération ou de réactivation
• C02F 1/28 - Traitement de l'eau, des eaux résiduaires ou des eaux d'égout par absorption ou adsorption

Abrégé

Provided are: a novel complex capable of efficiently adsorbing and collecting arsenic (V) dissolved in water; and a novel arsenic adsorbent.　This complex contains iron (III)-containing particles supported on microfibrous cellulose. At least a portion of the iron (III)-containing particles has an aspect ratio of 2 or more.　The iron (III)-containing particles preferably contain at least one iron compound selected from iron oxides, iron hydroxides, and iron oxyhydroxides.　This arsenic adsorbent contains the complex.

Classes IPC  ?

• B01J 20/02 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtrationAbsorbants ou adsorbants pour la chromatographieProcédés pour leur préparation, régénération ou réactivation contenant une substance inorganique
• B01J 20/30 - Procédés de préparation, de régénération ou de réactivation
• C02F 1/28 - Traitement de l'eau, des eaux résiduaires ou des eaux d'égout par absorption ou adsorption

Abrégé

The present invention provides a novel complex having the effect of efficiently adsorbing and collecting arsenic(V) dissolved in water, and a novel arsenic adsorbent.　A complex according to the present disclosure has a structure in which metal particles including zero-valent and/or trivalent iron are supported on a microfibrous cellulose surface.　The metal particles of the complex contain at least one type of metal oxide, hydroxide, or oxyhydroxide selected from zirconium and titanium, together with zero-valent and/or trivalent iron. The molar ratio [iron/(zirconium + titanium)] of the iron (elementary iron equivalent) and the metal oxide, hydroxide, or oxyhydroxide (elementary metal equivalent; total amount when containing two or more compounds) is preferably 1-100.　An arsenic adsorbent according to the present disclosure contains the complex.

Classes IPC  ?

• B01J 20/02 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtrationAbsorbants ou adsorbants pour la chromatographieProcédés pour leur préparation, régénération ou réactivation contenant une substance inorganique
• B01J 20/30 - Procédés de préparation, de régénération ou de réactivation
• C02F 1/28 - Traitement de l'eau, des eaux résiduaires ou des eaux d'égout par absorption ou adsorption

Abrégé

Provided are [0] extracellular vesicles that present at least one cytokine extramembranously; [1] extracellular vesicles that present at least one target factor extramembranously; or [2] extracellular vesicles that present at least one target factor and at least one cytokine extramembranously.

Classes IPC  ?

• C12N 5/071 - Cellules ou tissus de vertébrés, p. ex. cellules humaines ou tissus humains
• A61K 35/12 - Substances provenant de mammifèresCompositions comprenant des tissus ou des cellules non spécifiésCompositions comprenant des cellules souches non embryonnairesCellules génétiquement modifiées
• A61P 7/06 - Antianémiques
• A61P 35/00 - Agents anticancéreux
• A61P 43/00 - Médicaments pour des utilisations spécifiques, non prévus dans les groupes
• C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
• C07K 14/52 - CytokinesLymphokinesInterférons
• C07K 14/705 - RécepteursAntigènes de surface cellulaireDéterminants de surface cellulaire
• C07K 19/00 - Peptides hybrides
• C12N 5/0735 - Cellules souches embryonnairesCellules germinales embryonnaires
• C12N 5/074 - Cellules souches adultes
• C12N 5/10 - Cellules modifiées par l'introduction de matériel génétique étranger, p. ex. cellules transformées par des virus
• C12N 15/12 - Gènes codant pour des protéines animales
• C12N 15/19 - InterféronsLymphokinesCytokines
• C12N 15/62 - Séquences d'ADN codant pour des protéines de fusion
• C12N 15/85 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules animales

Abrégé

Provided are a novel complex capable of efficiently adsorbing and collecting arsenic(V) dissolved in water, and a novel arsenic adsorbent. This complex contains iron(III)-containing particles supported on microfibrous cellulose, and at least a portion of the iron(III)-containing particles has an aspect ratio of two or more. The iron(III)-containing particles preferably contain at least one iron compound selected from iron oxides, iron hydroxides, and iron oxyhydroxides. The arsenic adsorbent contains the complex.

Classes IPC  ?

• B01J 20/02 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtrationAbsorbants ou adsorbants pour la chromatographieProcédés pour leur préparation, régénération ou réactivation contenant une substance inorganique
• B01J 20/30 - Procédés de préparation, de régénération ou de réactivation
• C02F 1/28 - Traitement de l'eau, des eaux résiduaires ou des eaux d'égout par absorption ou adsorption

Abrégé

A fuel flow groove formed in a fuel electrode current collector of a fuel electrode of a fuel cell includes a plurality of flow groove portions disposed in parallel, and a plurality of return groove portions connecting an end portion of one side edge portion or an end portion of the other side edge portion of the flow groove portions of two adjacent groups. Each of the return groove portions has an inner wall surface portion facing the end portion of the flow groove portions in the return groove portions. The inner wall surface portion has a curved surface shape in which a distance facing each other from the inner wall surface portion to the end portion of the flow groove portions, gradually decreases toward both end portions of the inner side wall surface portion in a direction orthogonal to an extending direction of the flow groove portions.

Classes IPC  ?

• H01M 8/026 - CollecteursSéparateurs, p. ex. séparateurs bipolairesInterconnecteurs caractérisés par la configuration des canaux, p. ex. par le champ d’écoulement du réactif ou du réfrigérant caractérisés par les rainures, p. ex. leur pas ou leur profondeur
• H01M 8/04082 - Dispositions pour la commande des paramètres des réactifs, p. ex. de la pression ou de la concentration
• H01M 8/0265 - CollecteursSéparateurs, p. ex. séparateurs bipolairesInterconnecteurs caractérisés par la configuration des canaux, p. ex. par le champ d’écoulement du réactif ou du réfrigérant les canaux des réactifs ou du réfrigérant ayant des sections transversales variables

Abrégé

The present disclosure provides an adsorbent which is produced using a low environmental load material as a raw material and adsorbs selenious acid selectively and efficiently. A selenious acid adsorbent according to the present disclosure includes a cellulose derivative (I) having a repeating unit represented by Formula (I). In Formula (I), each Ra represents a hydrogen atom, a group represented by Formula (a-1), or a group represented by Formula (a-2), and at least one of all the Ras included in the cellulose derivative is a group represented by Formula (a-1) or a group represented by Formula (a-2): The present disclosure provides an adsorbent which is produced using a low environmental load material as a raw material and adsorbs selenious acid selectively and efficiently. A selenious acid adsorbent according to the present disclosure includes a cellulose derivative (I) having a repeating unit represented by Formula (I). In Formula (I), each Ra represents a hydrogen atom, a group represented by Formula (a-1), or a group represented by Formula (a-2), and at least one of all the Ras included in the cellulose derivative is a group represented by Formula (a-1) or a group represented by Formula (a-2):

Classes IPC  ?

• B01J 20/24 - Composés macromoléculaires d'origine naturelle, p. ex. acides humiques ou leurs dérivés
• C02F 1/28 - Traitement de l'eau, des eaux résiduaires ou des eaux d'égout par absorption ou adsorption
• B01J 20/30 - Procédés de préparation, de régénération ou de réactivation

Abrégé

Provided is a method for simply and efficiently recovering an ionic liquid from a liquid mixture including the ionic liquid and an organic acid.　This method for recovering an ionic liquid from a liquid mixture including the ionic liquid and an organic acid is characterized in that the ionic liquid is water soluble, water and an organic solvent (excluding organic acids) are blended into the liquid mixture, and the organic acid is separated by extraction.

Classes IPC  ?

• C07D 233/58 - Composés hétérocycliques contenant des cycles diazole-1, 3 ou diazole-1, 3 hydrogéné, non condensés avec d'autres cycles comportant deux liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques avec uniquement des atomes d'hydrogène ou des radicaux ne contenant que des atomes d'hydrogène et de carbone, liés aux atomes de carbone du cycle avec uniquement des atomes d'hydrogène ou des radicaux ne contenant que des atomes d'hydrogène et de carbone, liés aux atomes d'azote du cycle
• C08B 3/06 - Acétate de cellulose
• C08B 3/22 - Traitement de post-estérification, y compris la purification

Abrégé

The present invention provides a method for easily and efficiently recovering an ionic liquid from a liquid mixture that contains the ionic liquid and an organic acid.　This method for recovering an ionic liquid is characterized by subjecting a liquid mixture (A) that contains an ionic liquid, an organic acid and a solvent (excluding an organic acid) to distillation.

Classes IPC  ?

• C07D 233/58 - Composés hétérocycliques contenant des cycles diazole-1, 3 ou diazole-1, 3 hydrogéné, non condensés avec d'autres cycles comportant deux liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques avec uniquement des atomes d'hydrogène ou des radicaux ne contenant que des atomes d'hydrogène et de carbone, liés aux atomes de carbone du cycle avec uniquement des atomes d'hydrogène ou des radicaux ne contenant que des atomes d'hydrogène et de carbone, liés aux atomes d'azote du cycle
• C08B 3/06 - Acétate de cellulose
• C08B 3/22 - Traitement de post-estérification, y compris la purification

Abrégé

Provided is a method for simply and efficiently recovering an ionic liquid from a liquid mixture including the ionic liquid and an organic acid.　This method for recovering an ionic liquid from a liquid mixture including the ionic liquid and an organic acid is characterized in that a solvent (excluding organic acids) is mixed into the liquid mixture and distillation is performed. The solvent is preferably a polar solvent. The HSP value (MPA)0.5 at 25°C of the polar solvent is preferably 15 or higher.

Classes IPC  ?

• C07D 233/58 - Composés hétérocycliques contenant des cycles diazole-1, 3 ou diazole-1, 3 hydrogéné, non condensés avec d'autres cycles comportant deux liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques avec uniquement des atomes d'hydrogène ou des radicaux ne contenant que des atomes d'hydrogène et de carbone, liés aux atomes de carbone du cycle avec uniquement des atomes d'hydrogène ou des radicaux ne contenant que des atomes d'hydrogène et de carbone, liés aux atomes d'azote du cycle
• C08B 3/06 - Acétate de cellulose
• C08B 3/22 - Traitement de post-estérification, y compris la purification

Abrégé

Provided is a method for simply and efficiently recovering an ionic liquid from a liquid mixture including the ionic liquid and an organic acid.　This method for recovering an ionic liquid from a liquid mixture including the ionic liquid and an organic acid is characterized in that the ionic liquid is water-soluble, at least one of water and an organic solvent (excluding organic acids) is blended into the liquid mixture, and the organic acid is separated by extraction.

Classes IPC  ?

• C07D 233/58 - Composés hétérocycliques contenant des cycles diazole-1, 3 ou diazole-1, 3 hydrogéné, non condensés avec d'autres cycles comportant deux liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques avec uniquement des atomes d'hydrogène ou des radicaux ne contenant que des atomes d'hydrogène et de carbone, liés aux atomes de carbone du cycle avec uniquement des atomes d'hydrogène ou des radicaux ne contenant que des atomes d'hydrogène et de carbone, liés aux atomes d'azote du cycle
• C08B 3/06 - Acétate de cellulose
• C08B 3/22 - Traitement de post-estérification, y compris la purification

Abrégé

The present disclosure provides a cellulose derivative which has excellent storage stability and can selectively adsorb a valuable metal and a toxic metal. The cellulose derivative of the present disclosure has a repeating unit represented by Formula (I) below. In Formula (I) below. Ras are identical or different and are a hydrogen atom or a group represented by Formula (a) below. In Formula (a) below, ring Z represents a heterocycle containing a nitrogen atom as a heteroatom, and R1 represents a single bond or an alkylene group having from 1 to 10 carbons. Four R2s are identical or different, and each represent an alkyl group having from 1 to 10 carbons. At least one of all the Ras included in the cellulose derivative is a group represented by Formula (a) below. The present disclosure provides a cellulose derivative which has excellent storage stability and can selectively adsorb a valuable metal and a toxic metal. The cellulose derivative of the present disclosure has a repeating unit represented by Formula (I) below. In Formula (I) below. Ras are identical or different and are a hydrogen atom or a group represented by Formula (a) below. In Formula (a) below, ring Z represents a heterocycle containing a nitrogen atom as a heteroatom, and R1 represents a single bond or an alkylene group having from 1 to 10 carbons. Four R2s are identical or different, and each represent an alkyl group having from 1 to 10 carbons. At least one of all the Ras included in the cellulose derivative is a group represented by Formula (a) below. The present disclosure provides a cellulose derivative which has excellent storage stability and can selectively adsorb a valuable metal and a toxic metal. The cellulose derivative of the present disclosure has a repeating unit represented by Formula (I) below. In Formula (I) below. Ras are identical or different and are a hydrogen atom or a group represented by Formula (a) below. In Formula (a) below, ring Z represents a heterocycle containing a nitrogen atom as a heteroatom, and R1 represents a single bond or an alkylene group having from 1 to 10 carbons. Four R2s are identical or different, and each represent an alkyl group having from 1 to 10 carbons. At least one of all the Ras included in the cellulose derivative is a group represented by Formula (a) below.

Classes IPC  ?

• B01J 20/24 - Composés macromoléculaires d'origine naturelle, p. ex. acides humiques ou leurs dérivés
• C02F 1/28 - Traitement de l'eau, des eaux résiduaires ou des eaux d'égout par absorption ou adsorption

Abrégé

A fuel cell includes a discharge structure that discharges water generated in a cathode electrode in association with an electrode reaction in the MEA to the outside. The discharge structure includes a discharge path through which air that is an oxidant flows, a passage that communicably connects an oxidant supply flow path and the discharge path and that moves water generated in the cathode electrode to the discharge path, and a discharge portion that discharges the generated water moved to the discharge path to the outside.

Classes IPC  ?

• H01M 8/04291 - Dispositions de gestion de l’eau dans les systèmes d’éléments à combustible à électrolyte solide
• H01M 8/0258 - CollecteursSéparateurs, p. ex. séparateurs bipolairesInterconnecteurs caractérisés par la configuration des canaux, p. ex. par le champ d’écoulement du réactif ou du réfrigérant
• H01M 8/04186 - Dispositions pour la commande des paramètres des réactifs, p. ex. de la pression ou de la concentration des réactifs chargés en liquide ou en électrolyte
• H01M 8/1009 - Éléments à combustible avec électrolytes solides avec un des réactifs liquide, solide ou chargé en liquide

Abrégé

[Problem] To provide a malaria vaccine which has an excellent preventative effect against infection and excellent effect of inhibiting malaria transmission, as compared to conventional malaria vaccines. [Solution] It was found that using, as a prime, a recombinant vaccinia virus which includes a gene that codes a CSP amino acid sequence and a gene that codes an s25 amino acid sequence, and using, as a boost, a recombinant adeno-associated virus which includes a gene that codes a CSP amino acid sequence and a gene that codes an s25 amino acid sequence results in a malaria vaccine which has an excellent preventative effect against infection and excellent effect of inhibiting malaria transmission.

Classes IPC  ?

• A61K 39/015 - Antigènes d'Hemosporidia, p. ex. antigènes de Plasmodium
• A61K 39/23 - Parvoviridae, p. ex. virus de l'aleucémie féline
• A61K 39/285 - Virus de la vaccine ou virus de la variole
• A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
• A61P 33/06 - Antipaludéens
• A61P 37/04 - Immunostimulants
• A61P 43/00 - Médicaments pour des utilisations spécifiques, non prévus dans les groupes
• C12N 7/01 - Virus, p. ex. bactériophages, modifiés par l'introduction de matériel génétique étranger
• C12N 15/30 - Gènes codant pour des protéines protozoaires, p. ex. Plasmodium, Trypanosoma, Eiméria
• C12N 15/863 - Vecteurs poxviraux, p. ex. virus de la vaccine
• C12N 15/864 - Vecteurs parvoviraux
• A61K 35/76 - VirusParticules sous-viralesBactériophages

Abrégé

A method for manufacturing diamond substrate of using source gas containing hydrocarbon gas and hydrogen gas to form diamond crystal on an underlying substrate by CVD method, to form a diamond crystal layer having nitrogen-vacancy centers in at least part of the diamond crystal, nitrogen or nitride gas is mixed in the source gas, wherein the source gas is: 0.005 volume % or more and 6.000 volume % or less of the hydrocarbon gas; 93.500 volume % or more and less than 99.995 volume % of the hydrogen gas; and 5.0×10−5 volume % or more and 5.0×10−1 volume % or less of the nitrogen gas or the nitride gas, and the diamond crystal layer having the nitrogen-vacancy centers is formed. A method for manufacturing a diamond substrate to form an underlying substrate, a diamond crystal having a dense nitrogen-vacancy centers (NVCs) with an orientation of NV axis by performing the CVD.

Classes IPC  ?

• C30B 29/04 - Diamant
• C23C 16/02 - Pré-traitement du matériau à revêtir
• C23C 16/27 - Le diamant uniquement
• C30B 25/18 - Croissance d'une couche épitaxiale caractérisée par le substrat
• H01F 1/40 - Aimants ou corps magnétiques, caractérisés par les matériaux magnétiques appropriésEmploi de matériaux spécifiés pour leurs propriétés magnétiques en matériaux inorganiques en matériaux semi-conducteurs magnétiques, p. ex. CdCr2S4
• C30B 25/20 - Croissance d'une couche épitaxiale caractérisée par le substrat le substrat étant dans le même matériau que la couche épitaxiale

Abrégé

To provide extracellular vesicles capable of satisfactorily activating, etc., antigen-specific T cells. Provided are said antigen-presenting extracellular vesicles that present an antigen-presenting MHC molecule and a T-cell-stimulating cytokine extramembranously.

Classes IPC  ?

• C12N 15/62 - Séquences d'ADN codant pour des protéines de fusion
• C07K 14/74 - Complexe majeur d'histocompatibilité [MHC]
• C12N 5/0783 - Cellules TCellules NKProgéniteurs de cellules T ou NK
• C07K 14/55 - IL-2
• C07K 14/54 - Interleukines [IL]
• C07K 14/52 - CytokinesLymphokinesInterférons
• C07K 14/495 - Facteur de croissance transformant [TGF]
• A61P 37/08 - Agents antiallergiques
• A61P 37/06 - Immunosuppresseurs, p. ex. médicaments pour le traitement du rejet de greffe
• A61P 35/00 - Agents anticancéreux

Abrégé

The present invention provides a novel semiconductor device for high breakdown voltage having no drift layer. The semiconductor device includes a first semiconductor layer of a first conductivity type which is either a p-type or an n-type conductivity type, a source portion arranged so as to be in contact with the first semiconductor layer and configured as a semiconductor portion of a second conductivity type different from the first conductivity type, a source electrode arranged in ohmic contact with the source portion, a gate electrode arranged on at least one selected from surfaces of the first semiconductor layer via a gate insulating film interposed therebetween and capable of forming by an applied electric field, an inversion layer in a region of the first semiconductor layer near the surface of the first semiconductor layer contacting the gate insulating film, a second semiconductor layer of the first conductivity type arranged so as to be in contact with the inversion layer, and a drain electrode separated from the inversion layer and arranged in Schottky contact with the second semiconductor layer.

Classes IPC  ?

• H01L 29/78 - Transistors à effet de champ l'effet de champ étant produit par une porte isolée
• H01L 29/16 - Corps semi-conducteurs caractérisés par les matériaux dont ils sont constitués comprenant, mis à part les matériaux de dopage ou autres impuretés, seulement des éléments du groupe IV de la classification périodique, sous forme non combinée
• H01L 29/41 - Electrodes caractérisées par leur forme, leurs dimensions relatives ou leur disposition relative

Abrégé

The present invention provides a diamond laminate which has excellent electron emission ability and is capable of forming an electrode reaction field that has excellent reductiveness.　A laminate according to the present disclosure comprises: an electron excitation layer (1) that has a diamond crystal structure in which some carbon atoms are substituted by nitrogen atoms; and a conductive layer (2) that has a diamond crystal structure in which some carbon atoms are substituted by boron atoms.　It is preferable that the nitrogen atom concentration in the layer (1) is 5 × 1018atoms/cm3or more; and it is preferable that the boron atom concentration in the layer (2) is 1 × 1019atoms/cm3 or more.　It is preferable that the thickness of the layer (1) is 1 nm to 100 µm; and it is preferable that the thickness of the layer (2) is 1 µm or more.

Classes IPC  ?

• C25B 11/083 - Diamant
• B32B 9/00 - Produits stratifiés composés essentiellement d'une substance particulière non couverte par les groupes
• C01B 32/25 - Diamant
• C25B 1/23 - Oxyde de carbone ou gaz de synthèse
• C25B 1/55 - Photo-électrolyse
• C25B 9/00 - Cellules ou assemblages de cellulesÉléments de structure des cellulesAssemblages d'éléments de structure, p. ex. assemblages d'électrode-diaphragmeCaractéristiques des cellules relatives aux procédés
• C25B 11/065 - Carbone
• C25B 11/087 - Composé photo-catalytique

Abrégé

A magnetostrictive vibrational power generator that obtains power using the magnetostriction effect produced in a magnetostriction element 13, and is obtained by comprising: a beam member 10 that has one end configured as a free end and the other end configured as a fixed end, and is integrally provided with a rod-shaped magnetostriction element 13 and a frame 12 to which the magnetostriction element 13 is mounted; magnets 14a, b that impart a magnetic bias to the magnetostriction element 13; a coil 15 that is wound around the magnetostriction element 13 so as to be penetrated by the magnetic flux produced by the magnetostriction element 13 to which the magnetic bias has been applied; and a rotational tab member 20 that is positioned near the beam member 10, and is obtained by arranging, at prescribed intervals on an outer circumferential section of a rotational body 21, a plurality of tab sections 23 which pull the free end of the frame 12 such that the magnetostriction element 13 sags.

Classes IPC  ?

• H02N 2/18 - Machines électriques en général utilisant l'effet piézo-électrique, l'électrostriction ou la magnétostriction fournissant une sortie électrique à partir d'une entrée mécanique, p. ex. générateurs
• H10N 35/00 - Dispositifs magnétostrictifs

Abrégé

The invention provides a polynucleotide including at least one of (a) a sequence encoding a fusion protein including an antigen-presenting MHC molecule capable of being presented extramembranously of an extracellular vesicle; (b) a sequence encoding a fusion protein including a T cell stimulating cytokine or a subunit thereof capable of being presented extramembranously of an extracellular vesicle; (c) a sequence encoding a fusion protein including a T cell co-stimulatory molecule capable of being presented extramembranously of an extracellular vesicle; (d) a sequence encoding a fusion protein including an antigen-presenting MHC molecule and a T cell stimulating cytokine or a subunit thereof capable of being presented extramembranously of an extracellular vesicle; and (e) a sequence encoding a fusion protein including an antigen-presenting MHC molecule, a T cell stimulating cytokine or a subunit thereof, and a T cell co-stimulatory molecule capable of being presented extramembranously of an extracellular vesicle.

Classes IPC  ?

• C07K 14/55 - IL-2
• C12N 15/85 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules animales
• C12N 5/0783 - Cellules TCellules NKProgéniteurs de cellules T ou NK
• C07K 14/74 - Complexe majeur d'histocompatibilité [MHC]
• C07K 14/705 - RécepteursAntigènes de surface cellulaireDéterminants de surface cellulaire
• C07K 14/485 - Facteur de croissance de l'épiderme [EGF], c.-à-d. urogastrone
• C07K 14/54 - Interleukines [IL]
• C07K 14/495 - Facteur de croissance transformant [TGF]
• A61K 35/15 - Cellules de la lignée des myéloïdes, p. ex. granulocytes, basophiles, éosinophiles, neutrophiles, leucocytes, monocytes, macrophages ou mastocytesCellules précurseurs myéloïdesCellules présentatrices d’antigène, p. ex. cellules dendritiques

Abrégé

Provided is a water-insoluble crosslinked structure having an excellent metal-scavenging effect.　In this crosslinked structure, one linear polymer having a plurality of pendant groups represented by formula (a) and another linear polymer having a plurality of pendant groups represented by formula (a) are crosslinked as a result of some of the pendant groups in the one linear polymer and some of the pendant groups in the other linear polymer bonding to each other via a crosslinking agent. In the formula, the ring Z denotes a heterocyclic ring that contains a nitrogen atom as a heteroatom, and R1denotes a single bond or an alkylene group having 1-10 carbon atoms. Q+ denotes a counter cation.

Classes IPC  ?

• C08G 81/00 - Composés macromoléculaires obtenus par l'interréaction de polymères en l'absence de monomères, p. ex. polymères séquencés
• B01J 20/24 - Composés macromoléculaires d'origine naturelle, p. ex. acides humiques ou leurs dérivés
• B01J 20/26 - Composés macromoléculaires synthétiques
• C02F 1/28 - Traitement de l'eau, des eaux résiduaires ou des eaux d'égout par absorption ou adsorption
• C08B 3/14 - Préparation d'esters cellulosiques d'acides organiques dans lesquels le reste d'acide organique contient des substituants, p. ex. NH2, Cl
• C08F 8/30 - Introduction d'atomes d'azote ou de groupes contenant de l'azote
• C08F 8/34 - Introduction d'atomes de soufre ou de groupes contenant du soufre
• C08F 16/06 - Alcool polyvinylique
• C08G 59/02 - Polycondensats contenant plusieurs groupes époxyde par molécule
• C08G 79/00 - Composés macromoléculaires obtenus par des réactions créant dans la chaîne principale de la macromolécule une liaison contenant des atomes autres que le silicium, le soufre, l'azote, l'oxygène et le carbone, avec ou sans ces derniers éléments

Abrégé

Provided is a water-insoluble crosslinked structure having an exceptional metal scavenging effect.　In the crosslinked structure according to the present disclosure, one linear polymer having a plurality of pendant groups represented by formula (a) and another linear polymer having a plurality of pendant groups represented by formula (a) are crosslinked by binding some of the pendant groups of the one linear polymer and some of the pendant groups of the other linear polymer to one another using a cross-linking agent. In the formula, ring Z represents a heterocycle including a nitrogen atom as a heteroatom, and R1represents a single bond or a C1-10 alkylene group. Q+ represents a counter cation.

Classes IPC  ?

• C08G 81/00 - Composés macromoléculaires obtenus par l'interréaction de polymères en l'absence de monomères, p. ex. polymères séquencés
• B01J 20/24 - Composés macromoléculaires d'origine naturelle, p. ex. acides humiques ou leurs dérivés
• B01J 20/26 - Composés macromoléculaires synthétiques
• C02F 1/28 - Traitement de l'eau, des eaux résiduaires ou des eaux d'égout par absorption ou adsorption
• C08B 3/14 - Préparation d'esters cellulosiques d'acides organiques dans lesquels le reste d'acide organique contient des substituants, p. ex. NH2, Cl
• C08F 8/14 - Estérification
• C08F 8/30 - Introduction d'atomes d'azote ou de groupes contenant de l'azote
• C08F 8/34 - Introduction d'atomes de soufre ou de groupes contenant du soufre
• C08F 16/06 - Alcool polyvinylique
• C08G 59/02 - Polycondensats contenant plusieurs groupes époxyde par molécule
• C08G 79/00 - Composés macromoléculaires obtenus par des réactions créant dans la chaîne principale de la macromolécule une liaison contenant des atomes autres que le silicium, le soufre, l'azote, l'oxygène et le carbone, avec ou sans ces derniers éléments

Abrégé

This method for producing a fiber-reinforced composite material comprises: a fiber dispersion step for providing a fiber-dispersed resin by kneading a resin 10a with a fiber 10b to disperse the fiber 10b in the resin 10a; and a molecular weight reduction step in which, while transporting the fiber-dispersed resin along an outer peripheral surface of a screw body 37 provided with a passage 88 in the interior, the fiber-dispersed resin is passed from an entrance 91 to the passage 88 to an outlet 92 of the passage 88 and in combination therewith a shear force is applied to the fiber-dispersed resin by restricting the transport of the fiber-dispersed resin with a barrier element 82 disposed between the inlet 91 of the passage 88 at the outer peripheral surface and the outlet 92.

Classes IPC  ?

• B29B 7/38 - MélangeMalaxage continu, avec dispositifs mécaniques de mélange ou de malaxage avec dispositifs de mélange ou de malaxage mobiles rotatifs
• B29B 7/90 - Charges ou agents de renforcements
• B29C 48/375 - Plastificateurs, homogénéisateurs ou dispositifs d’alimentation à plusieurs étages
• B29C 48/51 - Vis avec des passages pour l'écoulement interne, p. ex. pour la matière fondue
• B29C 48/74 - Moyens de dérivation, c.-à-d. qu’une partie de la matière fondue est dirigée dans les étapes aval de l’extrudeuse
• B29K 105/12 - Présentation, forme ou état de la matière moulée contenant des agents de renforcement, charges ou inserts de longueur réduite, p. ex. filaments coupés, fibres coupées ou crins

Abrégé

Provided is a polynucleotide from which a cell or extracellular vesicle capable of satisfactorily activating antigen-specific T cells can be produced.　Provided is a polynucleotide containing at least one sequence selected from the group consisting of: (a) a sequence encoding a fusion protein (A) including an antigen-presenting MHC molecule and capable of presenting the antigen-presenting MHC molecule on the outside of the membrane of a cell or extracellular vesicle; (b) a sequence encoding a fusion protein (B) including at least one T cell stimulating cytokine or a subunit thereof and capable of presenting the T cell stimulating cytokine on the outside of the membrane of a cell or extracellular vesicle; (c) a sequence encoding a fusion protein (C) including a T cell co-stimulatory molecule and capable of presenting the T cell co-stimulatory molecule on the outside of the membrane of a cell or extracellular vesicle; (d) a sequence encoding a fusion protein (D) including an antigen-presenting MHC molecule and at least one T cell stimulating cytokine or a subunit thereof and capable of presenting the antigen and the T cell stimulating cytokine on the outside of the membrane of a cell or extracellular vesicle; and (e) a sequence encoding a fusion protein (E) including an antigen-presenting MHC molecule, at least one T cell stimulating cytokine or a subunit thereof, and a T cell co-stimulatory molecule and capable of presenting the antigen, the T cell stimulating cytokine, and the T cell co-stimulatory molecule on the outside of the membrane of a cell or extracellular vesicle.

Classes IPC  ?

• C12N 15/62 - Séquences d'ADN codant pour des protéines de fusion
• A61K 31/7088 - Composés ayant au moins trois nucléosides ou nucléotides
• A61K 36/06 - Champignons, p. ex. levures
• A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
• A61P 31/00 - Agents anti-infectieux, c.-à-d. antibiotiques, antiseptiques, chimiothérapeutiques
• A61P 35/00 - Agents anticancéreux
• A61P 37/02 - Immunomodulateurs
• A61P 37/08 - Agents antiallergiques
• C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
• C07K 14/495 - Facteur de croissance transformant [TGF]
• C07K 14/54 - Interleukines [IL]
• C07K 14/55 - IL-2
• C07K 14/74 - Complexe majeur d'histocompatibilité [MHC]
• C07K 19/00 - Peptides hybrides
• C12N 15/12 - Gènes codant pour des protéines animales
• C12N 15/19 - InterféronsLymphokinesCytokines
• C12N 15/24 - Interleukines
• C12N 15/26 - Interleukine-2
• C12N 15/63 - Introduction de matériel génétique étranger utilisant des vecteursVecteurs Utilisation d'hôtes pour ceux-ciRégulation de l'expression

Abrégé

A polyrotaxane of high heat resistance contains a linear molecule, a cyclic molecule enclosing the linear molecule such that the cyclic molecule is skewered with the linear molecule, and 5 blocking groups disposed at both ends of the linear molecule. The cyclic molecule contains an aromatic ring having, on a side chain, a phenolic hydroxyl group. The polyrotaxane can be produced by dissolving, in a methanol-containing solvent, a linear molecule and a cyclic 10 molecule containing an aromatic ring having, on a side chain, a phenolic hydroxyl group, to yield a pseudo polyrotaxane in which the cyclic molecule encloses the linear molecule such that the cyclic molecule is skewered with the linear molecule; and dissolving the pseudo polyrotaxane and a blocking group 15 material in a solvent, to dispose blocking groups at both ends of the linear molecule.

Classes IPC  ?

• C08G 65/26 - Composés macromoléculaires obtenus par des réactions créant une liaison éther dans la chaîne principale de la macromolécule à partir d'éthers cycliques par ouverture d'un hétérocycle à partir d'éthers cycliques et d'autres composés

Abrégé

Provided is a cellulose derivative which has a high amount of chelate adsorption groups introduced, has high hydrophilicity, and is capable of efficiently recovering boron.　This cellulose derivative has a repeating unit represented by formula (I-1) below. In formula (I-1), Ra's are the same or different and are each a hydroxyl group, or a group represented by formula (a) below. In formula (a), R1represents a hydrogen atom or a methyl group. R2represents a hydrogen atom, or a hydrocarbon group which may have a hydroxyl group. R3represents a hydrogen atom or a hydrocarbon group. In addition, at least one of all Ra's contained in the cellulose derivative is a group represented by formula (a) below.

Classes IPC  ?

• C08B 3/14 - Préparation d'esters cellulosiques d'acides organiques dans lesquels le reste d'acide organique contient des substituants, p. ex. NH2, Cl
• C02F 1/28 - Traitement de l'eau, des eaux résiduaires ou des eaux d'égout par absorption ou adsorption
• C08F 8/30 - Introduction d'atomes d'azote ou de groupes contenant de l'azote

Abrégé

The present invention relates to a cyber-physical system for optimizing a simulation model for chemical mechanical polishing based on actual measurement data of chemical mechanical polishing. The chemical mechanical polishing system includes a polishing apparatus (1) for polishing the workpiece (W) and an arithmetic system (47). The arithmetic system (47) includes a simulation model including at least a physical model configured to output an estimated polishing physical quantity including an estimated polishing rate of the workpiece (W). The arithmetic system (47) is configured to: input polishing conditions for the workpiece (W) into the simulation model; output the estimated polishing physical quantity of the workpiece (W) from the simulation model; and determine model parameters of the simulation model that bring the estimated polishing physical quantity closer to a measured polishing physical quantity of the workpiece (W).

Classes IPC  ?

• B24B 37/005 - Moyens de commande pour machines ou dispositifs de rodage
• B24B 53/017 - Dispositifs ou moyens pour dresser, nettoyer ou remettre en état les outils de rodage
• H01L 21/304 - Traitement mécanique, p. ex. meulage, polissage, coupe

Abrégé

A vibration power generation device that further improves power generation efficiency includes a vibration exciting body in which vibration is caused by a flowing fluid, a vibrated body that is oscillatable and connected to the vibration exciting body, and a power generator to generate electricity by oscillation of the vibrated body. The vibration exciting body is in proximity to a wall surface, and vibration is caused in the vibration exciting body by a fluid flowing along the wall surface.

Classes IPC  ?

• H02N 2/18 - Machines électriques en général utilisant l'effet piézo-électrique, l'électrostriction ou la magnétostriction fournissant une sortie électrique à partir d'une entrée mécanique, p. ex. générateurs

Abrégé

The present invention provides a method for detecting a biomarker for detecting hepatocytes with bile ductular proliferation, said method comprising a step for detecting laminin γ2 single chain or a nucleic acid encoding the same as the biomarker in a specimen.

Classes IPC  ?

• C12Q 1/6813 - Tests d’hybridation
• C12Q 1/686 - Réaction en chaine par polymérase [PCR]
• G01N 33/48 - Matériau biologique, p. ex. sang, urineHémocytomètres
• G01N 33/53 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet
• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides

Abrégé

The purpose of the present disclosure is to provide a polysaccharide nanofiber-blended polysaccharide composition production method which can be implemented easily and by which it is possible to obtain a polysaccharide nanofiber-blended polysaccharide composition that has mechanical properties that are strengthened by polysaccharide nanofibers.　One aspect of an embodiment of the present disclosure is a polysaccharide nanofiber-blended polysaccharide composition production method comprising: a step for obtaining a mixture by mixing a sol containing polysaccharide nanofibers (A), a polysaccharide (B), and a solvent (C) capable of dissolving the polysaccharide (B); and a step for obtaining a dried mixture by drying the mixture.

Classes IPC  ?

• C08L 1/02 - CelluloseCellulose modifiée
• B29C 70/12 - Façonnage de matières composites, c.-à-d. de matières plastiques comprenant des renforcements, des matières de remplissage ou des parties préformées, p. ex. des inserts comprenant uniquement des renforcements, p. ex. matières plastiques auto-renforçantes des renforcements fibreux uniquement caractérisées par la structure des renforcements fibreux utilisant des fibres courtes, p. ex. sous forme d'un mat
• C08B 11/02 - Alkyl ou cycloalkyléthers
• C08B 11/08 - Alkyl ou cycloalkyléthers à radicaux hydrocarbonés substitués à radicaux hydrocarbonés hydroxylésLeurs esters, éthers ou acétals
• C08B 11/12 - Alkyl ou cycloalkyléthers à radicaux hydrocarbonés substitués substitués par des radicaux acide substitués par des radicaux carboxyliques
• C08B 30/00 - Préparation de l'amidon, de l'amidon dégradé ou modifié par un traitement non chimique, de l'amylose ou de l'amylopectine
• C08B 37/00 - Préparation des polysaccharides non prévus dans les groupes Leurs dérivés
• C08B 37/08 - ChitineSulfate de chondroïtineAcide hyaluroniqueLeurs dérivés
• C08L 3/02 - AmidonSes produits de dégradation, p. ex. dextrine
• D01F 2/28 - Filaments, ou similaires, artificiels, à un seul composant, formés de cellulose ou de dérivés de la celluloseLeur fabrication à partir de dérivés de la cellulose à partir d'esters ou d'éthers organiques de cellulose, p. ex. à partir d'acétate de cellulose

Abrégé

A magnetostrictive power generation element (1) comprises: a magnetostrictive body unit (2) at least partially having a magnetostrictive body; a magnet for applying a magnetic bias to the magnetostrictive body; a coil; and a bobbin (5) having a hollow portion (5b) and housing at least a part of the magnetostrictive body in the hollow portion (5b). The bobbin (5) has a wound portion (5c), around which the coil is wound, on the outer periphery of a region in which the hollow portion (5b) is provided.

Classes IPC  ?

• H02N 2/18 - Machines électriques en général utilisant l'effet piézo-électrique, l'électrostriction ou la magnétostriction fournissant une sortie électrique à partir d'une entrée mécanique, p. ex. générateurs
• H01F 5/02 - Bobines d'induction enroulées sur des supports non magnétiques, p. ex. mandrins

Abrégé

Provided are a fine particle adsorption material and removal method that enable sufficient removal of fine particles from a solvent having a low water content. This fine particle adsorption material is for adsorbing and removing fine particles from a solvent containing the fine particles. The material has a graft chain that is a negatively charged group. A polymer material that serves as a base material for the fine particle adsorption material is an aliphatic hydrocarbon, or an aliphatic hydrocarbon containing fluorine or chlorine. This method for removing fine particles from a solvent comprises bringing said fine particle adsorption material into contact with the solvent, and thereby causing the fine particles in the solvent to be adsorbed by the fine particle adsorption material and to be removed from the solvent.

Classes IPC  ?

• B01D 15/00 - Procédés de séparation comportant le traitement de liquides par des adsorbants ou des absorbants solidesAppareillages pour ces procédés
• B01D 15/04 - Procédés de séparation comportant le traitement de liquides par des adsorbants ou des absorbants solidesAppareillages pour ces procédés par des substances échangeuses d'ions comme adsorbants
• B01J 39/05 - Procédés utilisant des échangeurs organiques sous forme fortement acide
• B01J 39/20 - Composés macromoléculaires obtenus par des réactions ne faisant intervenir que des liaisons carbone-carbone non saturées
• B01J 47/12 - Procédés d'échange d'ions en généralAppareillage à cet effet caractérisés par l'emploi d'une substance échangeur d'ions sous forme de rubans, de filaments, de fibres ou de feuilles, p. ex. sous forme de membranes
• B01J 47/127 - Procédés d'échange d'ions en généralAppareillage à cet effet caractérisés par l'emploi d'une substance échangeur d'ions sous forme de rubans, de filaments, de fibres ou de feuilles, p. ex. sous forme de membranes sous forme de filaments ou de fibres
• B01J 20/26 - Composés macromoléculaires synthétiques

Abrégé

A fuel cell system having a direct liquid fuel cell that uses a liquid containing a formic acid or an alcohol as a fuel includes: a fuel tank that stores the fuel to be supplied to the fuel cell; a fuel supply device that supplies the fuel in the fuel tank to the fuel cell; and a bubbling device that blows an inert gas into the fuel stored in the fuel tank.

Classes IPC  ?

• H01M 8/04 - Dispositions auxiliaires, p. ex. pour la commande de la pression ou pour la circulation des fluides
• H01M 8/04186 - Dispositions pour la commande des paramètres des réactifs, p. ex. de la pression ou de la concentration des réactifs chargés en liquide ou en électrolyte
• H01M 8/04746 - PressionDébit
• H01M 8/0668 - Élimination du monoxyde de carbone ou du dioxyde de carbone
• H01M 8/1011 - Éléments à combustible à alcool direct, p. ex. éléments à combustible à méthanol direct

Abrégé

The present invention provides a composition for regulating carbohydrate metabolism, the composition containing, as an active ingredient, an agent for controlling the amount of D-amino acid in the living body of a subject. Moreover, the present invention provides a method for assessing carbohydrate metabolism conditions of a subject by monitoring the amount of D-amino acid in the living body of the subject.

Classes IPC  ?

• A61K 45/00 - Préparations médicinales contenant des ingrédients actifs non prévus dans les groupes
• A61P 3/08 - Médicaments pour le traitement des troubles du métabolisme de l'homéostase du glucose
• A61P 3/10 - Médicaments pour le traitement des troubles du métabolisme de l'homéostase du glucose de l'hyperglycémie, p. ex. antidiabétiques
• A61P 9/12 - Antihypertenseurs
• A61K 31/519 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime condensées en ortho ou en péri avec des hétérocycles
• A23L 33/175 - Acides aminés

Abrégé

A kneading state detection device (50) comprises: an AE wave acquisition unit (71) (acquisition unit) that acquires, when a twin-screw extruder (30) (extruder) for kneading a raw material or kneading a raw material with an additive is in operation, an AE output (M(t)) of an AE sensor (20) installed in a housing (32) of the twin-screw extruder (30); and a kneading state determination unit (72) (determination unit) that determines the kneading state of the raw material on the basis of a comparison between a change in the intensity of the AE output (M(t)) of the AE sensor (20) acquired by the AE wave acquisition unit (71) and a threshold value (Th).

Classes IPC  ?

• G01N 29/14 - Recherche ou analyse des matériaux par l'emploi d'ondes ultrasonores, sonores ou infrasonoresVisualisation de l'intérieur d'objets par transmission d'ondes ultrasonores ou sonores à travers l'objet utilisant des techniques d'émission acoustique
• B29B 7/22 - Éléments constitutifs, détails ou accessoiresOpérations auxiliaires
• B29B 7/58 - Éléments constitutifs, détails ou accessoiresOpérations auxiliaires
• B29C 48/40 - Moyens pour plastifier ou homogénéiser la matière à mouler ou pour la forcer dans la filière ou la matrice utilisant des vis entourées par un fourreau coopérant, p. ex. des extrudeuses à vis simple utilisant au moins deux vis parallèles, p. ex. extrudeuses à vis doubles
• B29C 48/92 - Mesure, commande ou régulation

Abrégé

Provided is a method that enables industrially efficient production of an esterified polysaccharide product. A method for producing an esterified polysaccharide product, the method including reacting a polysaccharide-containing biomass, a basic ionic liquid with a pKa of a conjugate acid of an anion from 2 to 19 as a calculated value in a vacuum, and an esterifying agent using a kneader equipped with a shear force application mechanism. A cation constituting the basic ionic liquid is preferably one selected from the group consisting of an imidazolium cation, a pyridinium cation, and a tetraalkylammonium cation.

Classes IPC  ?

• C08B 3/06 - Acétate de cellulose
• B29C 48/40 - Moyens pour plastifier ou homogénéiser la matière à mouler ou pour la forcer dans la filière ou la matrice utilisant des vis entourées par un fourreau coopérant, p. ex. des extrudeuses à vis simple utilisant au moins deux vis parallèles, p. ex. extrudeuses à vis doubles

Abrégé

A production method for a low molecular weight polymer suitable for a melt-blown non-woven fabric and a production device for melt-blown non-woven fabric, with which a high molecular weight polymer can be reduced in molecular weight by applying a shear force to the high molecular weight polymer without adding an additive. The low molecular weight polymer and the melt-blown non-woven fabric are produced using a continuous high shearing device that applies a shear force to the high molecular weight polymer serving as a raw material by rotation of a screw body to reduce the molecular weight of the high molecular weight polymer so as to obtain a low molecular weight polymer, and cools the low molecular weight polymer by passing the low molecular weight polymer through a passage arranged in the axial direction inside the screw body.

Classes IPC  ?

• D04H 1/56 - Non-tissés formés uniquement ou principalement de fibres coupées ou autres fibres similaires relativement courtes à partir de voiles ou couches composés de fibres ne possédant pas des propriétés cohésives réelles ou potentielles par soudage des fibres ensembles, p. ex. par fusion partielle ou dissolution en association avec la formation de la fibre, p. ex. suivant immédiatement l'extrusion des fibres en brin
• B29C 48/88 - Traitement thermique de l’écoulement de matière extrudée, p. ex. refroidissement
• B29C 48/86 - Traitement thermique de la matière à mouler par extrusion ou des pièces ou des couches préformées, p. ex. par chauffage ou refroidissement dans la zone de la filière
• B29C 48/30 - Filières ou matrices d’extrusion
• B29C 48/05 - Moulage par extrusion, c.-à-d. en exprimant la matière à mouler dans une matrice ou une filière qui lui donne la forme désiréeAppareils à cet effet caractérisées par la forme à l’extrusion de la matière extrudée filamentaire, p. ex. fils
• B29C 48/285 - Alimentation de l’extrudeuse en matière d’extrusion
• B29B 7/48 - MélangeMalaxage continu, avec dispositifs mécaniques de mélange ou de malaxage avec dispositifs de mélange ou de malaxage mobiles rotatifs avec plus d'un arbre à dispositifs à engrènement, p. ex. à vis qui s'engrènent
• B29B 7/72 - Mesure, commande ou régulation
• B29B 7/82 - Chauffage ou refroidissement
• D04H 1/4291 - Famille des oléfines

Abrégé

A signal acquisition unit of an abnormality detection device for a twin-screw extrusion molding machine, when the twin-screw extrusion molding machine that melts and kneads a fed resin raw material is in operation, acquires an AE output of an AE sensor installed on a surface of a housing of the twin-screw extrusion molding machine. A determination unit determines whether an abnormality occurs in the twin-screw extrusion molding machine, based on a relationship between the AE output and a first threshold and a second threshold.

Classes IPC  ?

• B29C 48/92 - Mesure, commande ou régulation
• G01M 99/00 - Matière non prévue dans les autres groupes de la présente sous-classe

Abrégé

A fuel cell system (1) comprises: a fuel cell (10); a power recovery device (30); and a control device (20) that controls the fuel cell (10) and the power recovery device (30). In a state in which the supply of liquid fuel to the fuel cell (10) has been stopped, by carrying out charging with post-stoppage power generated by the fuel cell (10) using liquid fuel that was already supplied, the control device (20) causes the power recovery device (30) to recover the post-stoppage power, and after the same has been recovered, the control device stops electrode reactions in an electrode structure of the fuel cell (10).

Classes IPC  ?

• H01M 8/04228 - Dispositions auxiliaires, p. ex. pour la commande de la pression ou pour la circulation des fluides pendant le démarrage ou l’arrêtDépolarisation ou activation, p. ex. purgeMoyens pour court-circuiter les éléments à combustible défectueux pendant l’arrêt
• H01M 8/04 - Dispositions auxiliaires, p. ex. pour la commande de la pression ou pour la circulation des fluides
• H01M 8/04303 - Procédés de commande des éléments à combustible ou des systèmes d’éléments à combustible appliqués pendant des périodes spécifiques appliqués pendant l’arrêt
• H01M 8/0438 - PressionPression ambianteDébit
• H01M 8/04537 - Variables électriques
• H01M 8/04858 - Variables électriques
• H01M 8/10 - Éléments à combustible avec électrolytes solides

Abrégé

Provided are a fine particle production apparatus and a fine particle production method that can control the particle sizes of fine particles, and efficiently produce a large amount of fine particles having good particle size uniformity. The present invention comprises: a raw material supply unit which supplies raw materials for fine particle production into thermal plasma flame; a plasma torch in which the thermal plasma flame is generated, and which evaporates the raw material supplied by the raw material supply unit by means of the thermal plasma flame to form a mixture in a gas phase state; and a plasma generation unit which generates thermal plasma flame inside the plasma torch. The plasma generation unit includes: a first coil which surrounds the plasma torch, a second coil which is installed below the first coil in the longitudinal direction of the plasma torch and surrounds the circumference of the plasma torch; a first power supply unit which supplies an amplitude-modulated first high-frequency current to the first coil; and a second power supply unit which supplies an amplitude-modulated second high-frequency current to the second coil. The degree of modulation of the first high-frequency current is smaller than the degree of modulation of the second high-frequency current.

Classes IPC  ?

• B22F 9/14 - Fabrication des poudres métalliques ou de leurs suspensionsAppareils ou dispositifs spécialement adaptés à cet effet par des procédés physiques en utilisant des décharges électriques
• B22F 9/12 - Fabrication des poudres métalliques ou de leurs suspensionsAppareils ou dispositifs spécialement adaptés à cet effet par des procédés physiques à partir d'un produit gazeux
• H05H 1/42 - Torches à plasma utilisant un arc avec des dispositions pour l'introduction de matériaux dans le plasma, p. ex. de la poudre ou du liquide

Abrégé

Described herein are sulfonamide derivatives of Formula (I) capable of inhibiting RNA dependent RNA polymerase (RdRP) activity of cancer cells. Also described are pharmaceutical compositions comprising these compounds and the uses thereof in the prophylaxis and/or treatment of cancers, including intractable solid cancers and stem cells cancer. The pharmaceutical composition may further comprise at least one of an hormonal therapeutic agent, a chemotherapeutic agent, an immunotherapeutic agent, a pharmaceutical agent inhibiting the action of cell growth factor and a pharmaceutical agent inhibiting the action of cell growth factor receptor.

Classes IPC  ?

• A61K 31/47 - QuinoléinesIsoquinoléines
• A61P 35/00 - Agents anticancéreux
• C07D 215/20 - Atomes d'oxygène

Abrégé

A purpose of the present invention is to provide a cellulose nanofiber composition which, in a dried state, has excellent redispersibility. The cellulose nanofiber composition comprises modified cellulose nanofibers having an ionic functional group and a betaine compound having a molecular weight of 600 or less. The betaine compound is contained in an amount of preferably 5-1,000 parts by mass per 100 parts by mass of the modified cellulose nanofibers.

Classes IPC  ?

• C08L 1/08 - Dérivés de la cellulose
• C08B 15/04 - Carboxycellulose, p. ex. préparée par oxydation avec du peroxyde d'azote
• C08J 3/03 - Production de solutions, dispersions, latex ou gel par d'autres procédés que ceux utilisant les techniques de polymérisation en solution, en émulsion ou en suspension dans un milieux aqueux
• C08J 3/16 - Pulvérisation ou granulation par coagulation de dispersions
• C08K 5/19 - Composés d'ammonium quaternaire

Abrégé

This atomic force microscope (10) comprises a cantilever (11) provided with a downwardly protruding probe (12), a sample holding part (18) that holds a sample (99) such that the sample faces the cantilever (11), a drive unit (17) that drives at least one from among the cantilever (11) and sample holding part (18) such that the sample (99) moves in relation to the probe (12), and a control unit (for example, a PC (15)) that controls the drive unit (17) such that the surface of the sample (99) is scanned by the probe (12). In first direction scanning in which the sample (99) is moved from one end side to the other end side in relation to the probe (12), the control unit brings the sample (99) and probe (12) together to a first distance and scans the sample (99) at a first speed. In second direction scanning in which the sample (99) is moved from the other end side to the one end side in relation to the probe (12), the control unit moves the sample (99) and probe (12) apart to a second distance further than the first distance and scans the sample (99) at a second speed faster than the first speed.

Classes IPC  ?

• G01Q 10/04 - Balayage ou positionnement fin
• G01Q 60/32 - Mode vibrant

Abrégé

Provided is a composition for promoting secretion of extracellular vesicles, which comprises a compound having a structure of the formula I (wherein each substituent is as defined in the specification), a racemate thereof or a stereoisomer thereof, or a salt thereof, or a compound having a structure of the formula II (wherein each substituent is as defined in the specification), or a stereoisomer thereof, or a salt thereof, or, cucurbitacin, or a stereoisomer thereof, or a salt thereof.

Classes IPC  ?

• C12N 5/0775 - Cellules souches mésenchymateusesCellules souches dérivées du tissu adipeux

Abrégé

An object of the present invention is to provide a method for producing a polysaccharide derivative in which the use of a reagent such as an acid catalyst is not needed and a reaction can be smoothly progressed without causing any side reactions. A method for producing a polysaccharide derivative of the present invention includes a step of dissolving a raw material including a polysaccharide in at least one ionic liquid having an anion which is a non-carboxylate anion and reacting the raw material with an acyl group donor, a conjugate acid of the anion having a pKa of 4 or higher in vacuum.

Classes IPC  ?

• C08B 3/10 - Préparation d'esters cellulosiques d'acides organiques d'acides organiques monobasiques à 3, ou plus, atomes de carbone à 5, ou plus, atomes de carbone

Abrégé

A method for causing a qualitative change in muscle fibers of a human or animal individual, includes the oral administration of a feed incorporating fermentation product dissolving solutions of thermophilic bacteria or Bacillus hisashn NITE BP-863 obtained by aeration treatment of a high-temperature fermentation product containing complex bacteria ATCC PTA-1773 as an active ingredient to the human or animal individual.

Classes IPC  ?

• A61K 35/742 - Bactéries sporulées, p. ex. Bacillus coagulans, Bacillus subtilis, clostridium ou Lactobacillus sporogenes
• A61P 21/00 - Médicaments pour le traitement des troubles du système musculaire ou neuromusculaire

Abrégé

A fine particle manufacturing apparatus and a fine particle manufacturing method are provided. The apparatus includes a raw material supply part supplying a raw material; a plasma torch in which the thermal plasma flame is generated and the raw material supplied by the raw material supply part is vaporized by using the thermal plasma flame to form a mixture in a gas phase state; and a plasma generation part generating the thermal plasma flame inside the plasma torch. The plasma generation part includes a first coil encircling the plasma torch; a second coil encircling the plasma torch and disposed below the first coil; a first power supply part supplying a high-frequency electric current to the first coil; and a second power supply part supplying an amplitude-modulated high-frequency electric current to the second coil. The first coil and the second coil are arranged in the longitudinal direction of the plasma torch.

Classes IPC  ?

• H05H 1/30 - Torches à plasma utilisant des champs électromagnétiques appliqués, p. ex. de l'énergie à haute fréquence ou sous forme de micro-ondes
• B01J 19/08 - Procédés utilisant l'application directe de l'énergie ondulatoire ou électrique, ou un rayonnement particulaireAppareils à cet usage
• C01B 33/021 - Préparation

Abrégé

The invention provides a composition for suppressing secretion of extracellular vesicle, which comprises a compound having a structure of the formula II (wherein, each substituent is as defined in the specification), or a pharmaceutically acceptable salt thereof, or a compound having a structure of the formula I (wherein, each substituent is as defined in the specification), or a metal complex thereof, or a pharmaceutically acceptable salt thereof.

Classes IPC  ?

• A61K 31/409 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p. ex. sulpiride, succinimide, tolmétine, buflomédil ayant quatre de ces cycles, p. ex. dérivés de la porphine, bilirubine, biliverdine
• A61P 35/00 - Agents anticancéreux
• A61K 31/404 - Indoles, p. ex. pindolol

Abrégé

This fuel battery comprises a discharge structure (F) which externally discharges produced water that is produced at a cathode electrode by an electrode reaction in an MEA (40). The discharge structure (F) is provided with: a discharge path (28) through which air that is an oxidant is to flow; a passage (29) which connects the discharge path (28) with an oxidant supply passage (21) so as to enable communication therebetween and which moves, to the discharge path (28), the produced water that has been produced at the cathode electrode; and a discharge unit (20c) which externally discharges the produced water that has been moved to the discharge path (28).

Classes IPC  ?

• H01M 8/0258 - CollecteursSéparateurs, p. ex. séparateurs bipolairesInterconnecteurs caractérisés par la configuration des canaux, p. ex. par le champ d’écoulement du réactif ou du réfrigérant
• H01M 8/0263 - CollecteursSéparateurs, p. ex. séparateurs bipolairesInterconnecteurs caractérisés par la configuration des canaux, p. ex. par le champ d’écoulement du réactif ou du réfrigérant comprenant des chemins zigzagants ou en serpentins
• H01M 8/04 - Dispositions auxiliaires, p. ex. pour la commande de la pression ou pour la circulation des fluides
• H01M 8/04746 - PressionDébit
• H01M 8/10 - Éléments à combustible avec électrolytes solides
• H01M 8/1009 - Éléments à combustible avec électrolytes solides avec un des réactifs liquide, solide ou chargé en liquide

Abrégé

Provided is an adsorbing material which is produced using a low environmental load material as a raw material, and adsorbs selenious acid selectively and efficiently.　A selenious acid-adsorbing material according to the present disclosure contains a cellulose derivative (I) having a repeating unit represented by formula (I). In the formula, Rais a hydrogen atom, a group represented by formula (a-1), or a group represented by formula (a-2). Moreover, at least one among all of Ra's contained in the cellulose derivative is a group represented by formula (a-1) or a group represented by formula (a-2).

Classes IPC  ?

• C02F 1/28 - Traitement de l'eau, des eaux résiduaires ou des eaux d'égout par absorption ou adsorption
• B01J 20/26 - Composés macromoléculaires synthétiques
• B01J 20/30 - Procédés de préparation, de régénération ou de réactivation

Abrégé

[Problem] To provide a mold, a molding system, and a mold manufacturing method which make it possible to easily and effectively spread mold release components of a mold release agent onto an inner surface of a mold without degrading the mold release agent, even with oil-based mold release agents, and which can achieve high manufacturing efficiency. [Solution] A pair of molds for molding a molded product in a gap therebetween is caused to be provided with a liquid path portion and a liquid infiltration layer configured by melting and solidifying metal powders, and a mold release agent is caused to be infiltrated into the gap. Specifically, the liquid infiltration layer is caused to be a thin layer having, at a high density, a liquid infiltration tube which is communicated with the molded surface and has a minute diameter. The liquid path portion is caused to have a 3D mesh structure having a meshed thin shaft, and is arranged along the liquid infiltration layer. The mold release agent is distributed while being in contact with the 3D mesh structure, thereby exerting such an advantageous effect that the mold release agent is not heated unevenly, and deterioration thereof is suppressed. When a form is adopted in which melting and solidifying are not performed with an axial direction of the thin shaft horizontal, this is preferable because easy melting and solidifying are achieved without breaking the thin shaft.

Classes IPC  ?

• B22D 17/20 - AccessoiresCoulée sous pression ou moulage par injection, c.-à-d. moulage en introduisant le métal dans le moule sous haute pression Parties constitutives
• B22D 17/22 - Moules métalliquesPlaques de moulesSupports de moulesÉquipement de refroidissement des moulesAccessoires pour l'extraction et l'éjection des pièces hors du moule
• B22F 3/105 - Frittage seul en utilisant un courant électrique, un rayonnement laser ou un plasma
• B22F 3/16 - Compactage et frittage par des opérations successives ou répétées
• B33Y 10/00 - Procédés de fabrication additive
• B29C 33/58 - Application d'agents de démoulage

Abrégé

Provided is a cellulose derivative that has excellent storage stability and that can selectively adsorb valuable metals and toxic metals.　The cellulose derivative according to the present invention has a repeating unit represented by formula (I). In formula (I), Ras are identical or different from each other, and each represent a hydrogen atom or a group represented by formula (a). In formula (a), ring Z represents a heterocyclic ring including a nitrogen atom as a heteroatom, and R1represents a single bond or an alkylene group having 1-10 carbon atoms. The four R2s are identical or different from each other, and each represent an alkyl group having 1-10 carbon atoms. It should be noted that, of all Ras included in the cellulose derivative, at least one is a group represented by formula (a).

Classes IPC  ?

• B01J 20/24 - Composés macromoléculaires d'origine naturelle, p. ex. acides humiques ou leurs dérivés
• B01J 20/30 - Procédés de préparation, de régénération ou de réactivation
• C02F 1/28 - Traitement de l'eau, des eaux résiduaires ou des eaux d'égout par absorption ou adsorption
• C08B 3/14 - Préparation d'esters cellulosiques d'acides organiques dans lesquels le reste d'acide organique contient des substituants, p. ex. NH2, Cl

Abrégé

The present invention provides: a marker for determining critical stage kidney disease by using an indicator value based on the amount of D-alanine in the blood or the amount of D-alanine and L-alanine therein; a blood analysis method which uses said marker for patients undergoing surgery or intensive care; and a blood analysis system for determining critical stage kidney disease in patients undergoing surgery or intensive care.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
• G01N 33/70 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir la créatine ou la créatinine

Abrégé

A power generation element and an actuator for vibration power generation is provided that can be mass-produced at low cost while achieving increase in electromotive force. A power generation element includes a main series magnetic circuit having a frame yoke made of magnetic material and provided with a fixed portion that is one end and a free portion that is the other end across a U-shaped bent portion, a main magnet that applies a magnetic bias to the frame yoke, and a first gap formed at a position in contact with the free portion; and an auxiliary series magnetic circuit having an auxiliary yoke made of magnetic material and attached to the frame yoke, an auxiliary magnet that gives a magnetic bias to the auxiliary yoke, a second gap formed at a position facing the first gap across the free portion, the frame yoke, the main magnet, and the first gap. The amount of change in a main magnetic flux passing in a coil wound around the frame yoke increases when the free portion vibrates due to application of an external force and a magnetic resistance of the first gap and a magnetic resistance of the second gap increase or decrease reciprocally.

Classes IPC  ?

• H10N 35/00 - Dispositifs magnétostrictifs

Abrégé

[Problem] To provide a novel semiconductor device for high-voltage purposes having no drift layer. [Solution] The semiconductor device of the present invention comprises: a first semiconductor layer of a first conductivity type which is either p-type or n-type; a source portion comprising a semiconductor portion of a second conductivity type which is disposed in contact with the first semiconductor layer, the second conductivity type being different from the first conductivity type; a source electrode disposed in ohmic contact with the source portion; a gate electrode disposed in one of surfaces of the first semiconductor layer with a gate insulating film therebetween, and capable of forming, by means of an applied electric field, an inversion layer in a region of the first semiconductor layer in the vicinity of the surface thereof contacting the gate insulating film; a second semiconductor layer of the first conductivity type disposed in contact with the inversion layer; and a drain electrode spaced apart from the inversion layer and disposed in Schottky contact with the second semiconductor layer.

Classes IPC  ?

• H01L 29/78 - Transistors à effet de champ l'effet de champ étant produit par une porte isolée
• H01L 29/16 - Corps semi-conducteurs caractérisés par les matériaux dont ils sont constitués comprenant, mis à part les matériaux de dopage ou autres impuretés, seulement des éléments du groupe IV de la classification périodique, sous forme non combinée

Abrégé

Provided are a fine particle manufacturing apparatus and a fine particle manufacturing method, which manufacture smaller fine particles. The fine particle manufacturing apparatus has: a raw material supply unit that supplies raw materials for producing fine particles into a thermal plasma flame; a plasma torch in which the thermal plasma flame is generated and the raw materials supplied by the raw material supply unit is evaporated by the thermal plasma flame to form a mixture in a gaseous state; a plasma generation unit that generates the thermal plasma flame inside the plasma torch; and a gas supply unit that supplies quenched gas to the thermal plasma flame, wherein the gas supply unit supplies the quenched gas with time modulation of the supply amount of the quenched gas.

Classes IPC  ?

• B01J 19/08 - Procédés utilisant l'application directe de l'énergie ondulatoire ou électrique, ou un rayonnement particulaireAppareils à cet usage
• B01J 2/04 - Procédés ou dispositifs pour la granulation de substances, en généralTraitement de matériaux particulaires leur permettant de s'écouler librement, en général, p. ex. en les rendant hydrophobes par division du produit liquide en gouttelettes, p. ex. par pulvérisation, et solidification des gouttelettes en milieu gazeux
• B22F 9/14 - Fabrication des poudres métalliques ou de leurs suspensionsAppareils ou dispositifs spécialement adaptés à cet effet par des procédés physiques en utilisant des décharges électriques
• C01B 33/027 - Préparation par décomposition ou réduction de composés de silicium gazeux ou vaporisés autres que la silice ou un matériau contenant de la silice
• H05H 1/30 - Torches à plasma utilisant des champs électromagnétiques appliqués, p. ex. de l'énergie à haute fréquence ou sous forme de micro-ondes

Abrégé

The present invention relates to a cyber-physical system which optimizes a simulation model for chemical-mechanical polishing, on the basis of actual measurement data of chemical-mechanical polishing. The chemical-mechanical polishing system is provided with a polishing device (1) which polishes a workpiece (W), and a computation system (47). The computation system (47) has a simulation model which includes at least a physical model which outputs estimated polishing physical quantities including an estimated polishing rate of the workpiece (W). The computation system (47) inputs polishing conditions of the workpiece (W) into the simulation model and outputs the estimated polishing physical quantities of the work piece (W) from the simulation model, and determines model parameters of the simulation model which approximate the estimated polishing physical quantities to the actually measured polishing physical quantities of the workpiece (W).

Classes IPC  ?

• B24B 37/005 - Moyens de commande pour machines ou dispositifs de rodage
• B24B 53/017 - Dispositifs ou moyens pour dresser, nettoyer ou remettre en état les outils de rodage
• H01L 21/304 - Traitement mécanique, p. ex. meulage, polissage, coupe

Abrégé

[Problem] To provide a polyrotaxane having high heat resistance. [Solution] A polyrotaxane having a straight-chain molecule, a ring molecule encircling the straight-chain molecule in a skewered manner, and a blocking group disposed at both terminals of the straight-chain molecule, the polyrotaxane being characterized in that the ring molecule includes an aromatic ring having a phenol hydroxyl group in a side chain. The polyrotaxane can be manufactured via a manufacturing method that includes: a step for dissolving, in a solvent including methanol, a straight-chain molecule and a ring molecule that includes an aromatic ring having a phenol hydroxyl group in a side chain and obtaining a pseudo-polyrotaxane in which a ring molecule encircles the straight-chain molecule in a skewered manner; and a step for dissolving, in a solvent, the pseudo-polyrotaxane and a blocking group material and disposing the blocking group on both terminals of the straight-chain molecule.

Classes IPC  ?

• C07C 39/15 - Composés comportant au moins un groupe hydroxyle ou O-métal lié à un atome de carbone d'un cycle aromatique à six chaînons polycycliques sans autre insaturation que celle des cycles aromatiques tous les groupes hydroxyle étant liés à des cycles non condensés
• C08G 65/332 - Polymères modifiés par post-traitement chimique avec des composés organiques contenant de l'oxygène contenant des groupes carboxyle, ou leurs halogénures ou esters
• C08G 65/333 - Polymères modifiés par post-traitement chimique avec des composés organiques contenant de l'azote
• C07C 37/00 - Préparation de composés comportant des groupes hydroxyle ou O-métal liés à un atome de carbone d'un cycle aromatique à six chaînons

Abrégé

Provided is a laser cleaving method which, in processing of sapphire having a thickness of not less than several millimeters, reduces working time etc. and achieves high-quality parting. A laser light source 103 emits a laser beam 3 at a wavelength for which a sapphire plate 1 has a light absorbance of not less than 1% but less than 50%, and thermal stress which has been generated by the emission of the laser beam 3 is used to carry out cleavage by causing a crack to develop inside the sapphire plate 1, starting from a minute defect that is provided in the sapphire plate 1. The laser light source 103 emits a laser beam 3 which has a laser output power of not less than 60 W.

Classes IPC  ?

• B28D 5/00 - Travail mécanique des pierres fines, pierres précieuses, cristaux, p. ex. des matériaux pour semi-conducteursAppareillages ou dispositifs à cet effet
• B23K 26/50 - Travail par transmission du faisceau laser à travers ou dans la pièce à travailler
• B23K 26/60 - Traitement préliminaire
• B26F 3/06 - Séparation par la chaleur

Abrégé

To provide extracellular vesicles capable of satisfactorily activating, etc., antigen-specific T cells. Provided are said antigen-presenting extracellular vesicles that present an antigen-presenting MHC molecule and a T-cell-stimulating cytokine extramembranously.

Classes IPC  ?

• A61K 35/15 - Cellules de la lignée des myéloïdes, p. ex. granulocytes, basophiles, éosinophiles, neutrophiles, leucocytes, monocytes, macrophages ou mastocytesCellules précurseurs myéloïdesCellules présentatrices d’antigène, p. ex. cellules dendritiques
• C12N 5/0783 - Cellules TCellules NKProgéniteurs de cellules T ou NK
• A61K 38/19 - CytokinesLymphokinesInterférons
• A61P 35/00 - Agents anticancéreux
• A61P 37/06 - Immunosuppresseurs, p. ex. médicaments pour le traitement du rejet de greffe
• A61P 37/08 - Agents antiallergiques
• C07K 14/52 - CytokinesLymphokinesInterférons
• C07K 14/74 - Complexe majeur d'histocompatibilité [MHC]
• C07K 19/00 - Peptides hybrides
• C12N 5/10 - Cellules modifiées par l'introduction de matériel génétique étranger, p. ex. cellules transformées par des virus
• C12N 15/12 - Gènes codant pour des protéines animales
• C12N 15/19 - InterféronsLymphokinesCytokines
• C12N 15/62 - Séquences d'ADN codant pour des protéines de fusion
• C12N 15/63 - Introduction de matériel génétique étranger utilisant des vecteursVecteurs Utilisation d'hôtes pour ceux-ciRégulation de l'expression

Abrégé

To provide extracellular vesicles capable of satisfactorily activating, etc., antigen-specific T cells.　Provided are said antigen-presenting extracellular vesicles that present an antigen-presenting MHC molecule and a T-cell-stimulating cytokine extramembranously.

Classes IPC  ?

• A61P 35/00 - Agents anticancéreux
• A61P 37/06 - Immunosuppresseurs, p. ex. médicaments pour le traitement du rejet de greffe
• A61P 37/08 - Agents antiallergiques
• C07K 14/52 - CytokinesLymphokinesInterférons
• C07K 14/74 - Complexe majeur d'histocompatibilité [MHC]
• C07K 19/00 - Peptides hybrides
• C12N 5/0783 - Cellules TCellules NKProgéniteurs de cellules T ou NK
• C12N 5/10 - Cellules modifiées par l'introduction de matériel génétique étranger, p. ex. cellules transformées par des virus
• C12N 15/12 - Gènes codant pour des protéines animales
• C12N 15/19 - InterféronsLymphokinesCytokines
• C12N 15/62 - Séquences d'ADN codant pour des protéines de fusion
• C12N 15/63 - Introduction de matériel génétique étranger utilisant des vecteursVecteurs Utilisation d'hôtes pour ceux-ciRégulation de l'expression
• A61K 38/19 - CytokinesLymphokinesInterférons
• A61K 35/15 - Cellules de la lignée des myéloïdes, p. ex. granulocytes, basophiles, éosinophiles, neutrophiles, leucocytes, monocytes, macrophages ou mastocytesCellules précurseurs myéloïdesCellules présentatrices d’antigène, p. ex. cellules dendritiques

Abrégé

To provide a polynucleotide that makes it possible to produce extracellular vesicles capable of satisfactorily activating, etc., antigen-specific T cells.　Provided is a polynucleotide including at least one sequence selected from the group consisting of (a) a sequence encoding a fusion protein (A) including an antigen-presenting MHC molecule and capable of presenting the antigen-presenting MHC molecule extramembranously of an extracellular vesicle; (b) a sequence encoding a fusion protein (B) including at least one T cell stimulating cytokine or a subunit thereof and capable of presenting the T cell stimulating cytokine extramembranously of an extracellular vesicle; (c) a sequence encoding a fusion protein (C) including a T cell co-stimulatory molecule and capable of presenting the T cell co-stimulatory molecule extramembranously of an extracellular vesicle; (d) a sequence encoding a fusion protein (D) including an antigen-presenting MHC molecule and at least one T cell stimulating cytokine or a subunit thereof and capable of presenting the antigen and the T cell stimulating cytokine extramembranously of an extracellular vesicle; (e) a sequence encoding a fusion protein (E) including an antigen-presenting MHC molecule, at least one T cell stimulating cytokine or a subunit thereof, and a T cell co-stimulatory molecule and capable of presenting the antigen, the T cell stimulating cytokine, and the T cell co-stimulatory molecule extramembranously of an extracellular vesicle.

Classes IPC  ?

• C12N 15/62 - Séquences d'ADN codant pour des protéines de fusion
• A61K 35/15 - Cellules de la lignée des myéloïdes, p. ex. granulocytes, basophiles, éosinophiles, neutrophiles, leucocytes, monocytes, macrophages ou mastocytesCellules précurseurs myéloïdesCellules présentatrices d’antigène, p. ex. cellules dendritiques
• A61K 38/19 - CytokinesLymphokinesInterférons
• A61P 35/00 - Agents anticancéreux
• A61P 37/06 - Immunosuppresseurs, p. ex. médicaments pour le traitement du rejet de greffe
• A61P 37/08 - Agents antiallergiques
• C07K 14/52 - CytokinesLymphokinesInterférons
• C07K 14/74 - Complexe majeur d'histocompatibilité [MHC]
• C07K 19/00 - Peptides hybrides
• C12N 5/0783 - Cellules TCellules NKProgéniteurs de cellules T ou NK
• C12N 5/10 - Cellules modifiées par l'introduction de matériel génétique étranger, p. ex. cellules transformées par des virus
• C12N 15/12 - Gènes codant pour des protéines animales
• C12N 15/19 - InterféronsLymphokinesCytokines
• C12N 15/63 - Introduction de matériel génétique étranger utilisant des vecteursVecteurs Utilisation d'hôtes pour ceux-ciRégulation de l'expression

Abrégé

The present invention pertains to a pharmaceutical composition for the prevention or treatment of kidney disease, a kidney inflammation inhibitor, an inflammatory cell death inhibitor for the kidneys, or a food for the prevention or improvement of kidney disease, that include D-alanine or a derivative thereof. In addition, the present invention pertains to the use of D-alanine or a derivative thereof, for the production of a pharmaceutical composition for the prevention or treatment of kidney disease.

Classes IPC  ?

• A61K 31/198 - Alpha-amino-acides, p. ex. alanine ou acide édétique [EDTA]
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61P 13/12 - Médicaments pour le traitement des troubles du système urinaire des reins

Abrégé

The present invention provides a method for producing a silyl etherified product of a polysaccharide, said method using no highly corrosive reagent, while generating no highly corrosive by-product, no salt that is hard to process, and the like. A method for producing a silyl etherified product of a polysaccharide, said method comprising a step wherein a polysaccharide is reacted with a hydrosilane compound or a carboxylic acid silyl ester in dimethyl sulfoxide in the presence of a quaternary ammonium salt having anions that correspond to an acid having an acid dissociation constant pKa of from 12 to 19, thereby silyl etherifying a hydroxyl group of the polysaccharide. The reaction between the polysaccharide and the hydrosilane compound may be carried out in a carbon dioxide atmosphere.

Classes IPC  ?

• C08B 11/00 - Préparation d'éthers cellulosiques

Abrégé

It is an object of the present invention to obtain a novel composite material excellent in terms of flexibility and thermoformability from a lignocellulosic biomass as a raw material. It is an object of the present invention to obtain a novel composite material excellent in terms of flexibility and thermoformability from a lignocellulosic biomass as a raw material. A composite material, in which some hydroxy groups of a lignocellulosic biomass are esterified, which is characterized in that the esterified portion has short-chain acyl groups containing 2 to 4 carbon atoms and long-chain acyl groups containing 3 to 18 carbon atoms.

Classes IPC  ?

• C08H 8/00 - Composés macromoléculaires dérivés de matériaux lignocellulosiques
• C08L 97/02 - Matériau lignocellulosique, p. ex. bois, paille ou bagasse

Abrégé

Provided are: a method which is for producing a low-molecular-weight polymer suitable for a melt-blown non-woven fabric, and by which a low-molecular-weight polymer can be efficiently produced by applying a shearing force to a high-molecular-weight polymer without adding an additive such as a peroxide which promotes a pyrolysis reaction, to thereby reduce the molecular weight of the high-molecular-weight polymer; and a device for producing a melt-blown non-woven fabric. A low-molecular-weight polymer and a melt-blown non-woven fabric are produced by using a continuous high-shearing processing device which applies a shearing force to a high-molecular-weight polymer as a raw material through the rotation of a screw main body 37 and thereby reduces the molecular weight thereof to produce a low-molecular-weight polymer, and which cools the low-molecular-weight polymer by allowing the low-molecular-weight polymer to pass through a passage 88 provided in the axial direction inside the screw main body 37.

Classes IPC  ?

• C08J 3/00 - Procédés pour le traitement de substances macromoléculaires ou la formation de mélanges
• D04H 1/4291 - Famille des oléfines
• D04H 1/54 - Non-tissés formés uniquement ou principalement de fibres coupées ou autres fibres similaires relativement courtes à partir de voiles ou couches composés de fibres ne possédant pas des propriétés cohésives réelles ou potentielles par soudage des fibres ensembles, p. ex. par fusion partielle ou dissolution
• B29C 48/05 - Moulage par extrusion, c.-à-d. en exprimant la matière à mouler dans une matrice ou une filière qui lui donne la forme désiréeAppareils à cet effet caractérisées par la forme à l’extrusion de la matière extrudée filamentaire, p. ex. fils

Abrégé

−1 volume % or less of the nitrogen gas or the nitride gas, and the diamond crystal layer having the nitrogen-vacancy centers is formed. A method for manufacturing a diamond substrate to form an underlying substrate, a diamond crystal having a dense nitrogen-vacancy centers (NVCs) with an orientation of NV axis by performing the CVD.

Classes IPC  ?

• C30B 29/04 - Diamant
• C23C 16/02 - Pré-traitement du matériau à revêtir
• C23C 16/27 - Le diamant uniquement
• C30B 25/18 - Croissance d'une couche épitaxiale caractérisée par le substrat
• H01F 1/40 - Aimants ou corps magnétiques, caractérisés par les matériaux magnétiques appropriésEmploi de matériaux spécifiés pour leurs propriétés magnétiques en matériaux inorganiques en matériaux semi-conducteurs magnétiques, p. ex. CdCr2S4
• C30B 25/20 - Croissance d'une couche épitaxiale caractérisée par le substrat le substrat étant dans le même matériau que la couche épitaxiale
• H01F 10/10 - Pellicules magnétiques minces, p. ex. de structure à un domaine caractérisées par les couches magnétiques caractérisées par la composition
• C01B 32/25 - Diamant

Abrégé

This fuel cell system includes a direct liquid fuel cell that uses, as a fuel, a liquid containing formic acid or alcohol. The fuel cell system includes: a fuel tank for storing a fuel that is supplied to the fuel cell; a fuel supply device that supplies the fuel in the fuel tank to the fuel cell; and a bubbling device that blows an inert gas into the fuel stored in the fuel tank.

Classes IPC  ?

• H01M 8/04 - Dispositions auxiliaires, p. ex. pour la commande de la pression ou pour la circulation des fluides
• H01M 8/04186 - Dispositions pour la commande des paramètres des réactifs, p. ex. de la pression ou de la concentration des réactifs chargés en liquide ou en électrolyte
• H01M 8/043 - Procédés de commande des éléments à combustible ou des systèmes d’éléments à combustible appliqués pendant des périodes spécifiques
• H01M 8/04701 - Température
• H01M 8/04746 - PressionDébit
• H01M 8/04791 - ConcentrationDensité
• H01M 8/10 - Éléments à combustible avec électrolytes solides
• H01M 8/1009 - Éléments à combustible avec électrolytes solides avec un des réactifs liquide, solide ou chargé en liquide
• H01M 8/1011 - Éléments à combustible à alcool direct, p. ex. éléments à combustible à méthanol direct

Abrégé

This fuel cell system has a direct-liquid-type fuel cell that uses a liquid including formic acid or an alcohol as fuel, wherein the fuel cell has a fuel electrode, an air electrode, and an electrolyte film, and the fuel electrode has a fuel inlet port through which fuel is supplied and a fuel outlet port through which fuel is discharged. The fuel cell system includes: a fuel-supply and cleaning device that supplies fuel toward the fuel inlet port or supplies a cleaning fluid toward the fuel inlet port to clean the fuel electrode; and a control device that performs switching between the cleaning of the fuel electrode and the fuel supply carried out by the fuel-supply and cleaning device.

Classes IPC  ?

• H01M 8/008 - Élimination ou recyclage des éléments à combustible
• H01M 8/04 - Dispositions auxiliaires, p. ex. pour la commande de la pression ou pour la circulation des fluides
• H01M 8/043 - Procédés de commande des éléments à combustible ou des systèmes d’éléments à combustible appliqués pendant des périodes spécifiques
• H01M 8/04537 - Variables électriques
• H01M 8/04746 - PressionDébit
• H01M 8/04858 - Variables électriques
• H01M 8/10 - Éléments à combustible avec électrolytes solides
• H01M 8/1011 - Éléments à combustible à alcool direct, p. ex. éléments à combustible à méthanol direct

Abrégé

This fuel cell system includes: a direct liquid fuel cell which includes a fuel electrode that generates carbon dioxide when fuel is oxidized, and an air electrode that reduces oxygen; and fuel discharge piping for discharging fuel waste liquid containing carbon dioxide generated by the fuel electrode. The fuel discharge piping includes a carbon dioxide removing unit that removes cardon dioxide.

Classes IPC  ?

• H01M 8/04 - Dispositions auxiliaires, p. ex. pour la commande de la pression ou pour la circulation des fluides
• H01M 8/0668 - Élimination du monoxyde de carbone ou du dioxyde de carbone
• H01M 8/10 - Éléments à combustible avec électrolytes solides
• H01M 8/1011 - Éléments à combustible à alcool direct, p. ex. éléments à combustible à méthanol direct

Abrégé

In the present invention, a fuel distribution groove formed in a fuel electrode current collector of a fuel electrode comprises: a plurality of distribution groove portions that are arranged in parallel to each other; and a plurality of folded-back groove portions, each of which connects between ends of one-side edges of two adjacent sets of the distribution groove portions or ends of the other-side edges thereof. Each of the folded-back groove portions has an inner wall surface that faces ends of distribution groove portions corresponding to the folded-back groove portion, and the inner wall surface has a curved surface shape in which the distance to the respective ends of the opposing distribution groove portions gradually decreases, in a direction orthogonal to the direction in which the distribution groove portions extend, toward both end of the inner wall surface.

Classes IPC  ?

• H01M 8/0258 - CollecteursSéparateurs, p. ex. séparateurs bipolairesInterconnecteurs caractérisés par la configuration des canaux, p. ex. par le champ d’écoulement du réactif ou du réfrigérant
• H01M 8/026 - CollecteursSéparateurs, p. ex. séparateurs bipolairesInterconnecteurs caractérisés par la configuration des canaux, p. ex. par le champ d’écoulement du réactif ou du réfrigérant caractérisés par les rainures, p. ex. leur pas ou leur profondeur
• H01M 8/10 - Éléments à combustible avec électrolytes solides
• H01M 8/1011 - Éléments à combustible à alcool direct, p. ex. éléments à combustible à méthanol direct

Abrégé

In order to provide a method by which luminescent nanocarbons that exhibit strong luminescence within a long wavelength region of from 500 nm to 620 nm when excited by light that has a wavelength shorter than the emission wavelength are able to be produced, a method for producing luminescent nanocarbons according to the present invention is provided with a reaction step wherein a starting material solution is reacted to form luminescent nanocarbons. With respect to this method for producing luminescent nanocarbons, the starting material solution contains: at least one compound that is selected from the group consisting of benzene compounds having a hydroxy group, aliphatic hydroxy acids and aliphatic dicarboxylic acids; and at least one compound selected from among o-phenylenediamine and 1, 5-naphthalenediamine.

Classes IPC  ?

• C09K 11/08 - Substances luminescentes, p. ex. électroluminescentes, chimiluminescentes contenant des substances inorganiques luminescentes
• C09K 11/65 - Substances luminescentes, p. ex. électroluminescentes, chimiluminescentes contenant des substances inorganiques luminescentes contenant du carbone
• B82Y 40/00 - Fabrication ou traitement des nanostructures
• C01B 32/15 - Matières carbonées nanométriques

Abrégé

The present invention provides a resin composition which enables an aliphatic polycarbonate to exhibit the mechanical properties thereof with good reproducibility, and which is formed into a molded body that has a good balance among mechanical properties such as strength, elongation and fracture toughness.　A resin composition according to the present invention contains an aliphatic polycarbonate and a polylactic acid; and with respect to the aliphatic polycarbonate, the area ratio of the region where the molecular weight is 20,000 or less to the entire molecular weight region in the molecular weight distribution curve of the aliphatic polycarbonate as obtained by size exclusion chromatography is from 1% to 30%.

Classes IPC  ?

• C08G 64/02 - Polycarbonates aliphatiques
• C08G 64/34 - Procédés généraux de préparation utilisant du dioxyde de carbone et de éthers cycliques
• C08L 67/04 - Polyesters dérivés des acides hydroxycarboxyliques, p. ex. lactones
• C08L 69/00 - Compositions contenant des polycarbonatesCompositions contenant des dérivés des polycarbonates
• C08J 5/00 - Fabrication d'objets ou de matériaux façonnés contenant des substances macromoléculaires

Abrégé

According to the present invention, a signal acquisition unit (51a) (acquisition unit) of an abnormality detection device (50a) of a dual-axis extrusion molder (30) (extrusion molder) acquires an AE output (M(t)) of an AE sensor (20) installed on the surface of a housing (32) of the dual-axis extrusion molder (30) when the dual-axis extrusion molder (30) (extrusion molder) is in an operating state which melts and kneads an input resin raw material. In addition, a determination unit (53a) determines the occurrence of an abnormality in the dual-axis extrusion molder (30) on the basis of the relationship between the AE output (M(t)), a first threshold value (Th1), and a second threshold value (Th2).

Classes IPC  ?

• B29C 48/57 - Vis pourvues d’éléments de malaxage de type disque, p. ex. avec des éléments de forme ovale
• B29C 48/68 - Fourreaux ou cylindres
• B29C 48/92 - Mesure, commande ou régulation
• B29C 48/96 - Dispositifs de sécurité

Abrégé

Provided is a cancer biomarker that comprises placental leucine aminopeptidase in urine. Also provided is a method for judging the onset of ovarian cancer, said method comprising a step for measuring the amount of placental leucine aminopeptidase or the activity of placental leucine aminopeptidase in the urine of a subject.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
• C12N 9/64 - Protéinases provenant de tissu animal, p. ex. rennine
• C12Q 1/37 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une hydrolase faisant intervenir une peptidase ou une protéinase
• G01N 33/493 - Analyse physique de matériau biologique de matériau biologique liquide d'urine