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2025
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Invention
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Gene-drive in dna viruses.
In various embodiments methods of utilizing gene drive constructs in ... |
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Invention
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Inhibitors of cd38. The present disclosure provides compounds of Formula I and I*, tautomers of c... |
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Invention
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Cas enabled targeted transposition. Provided herein are polypeptides and associated methods for e... |
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2024
|
Invention
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Methods of inducing ketosis in non-human mammals.
The disclosure provides methods of inducing ke... |
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Invention
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Therapeutic targeting of hypdh/prodh2 and prodh1 to suppress 4-hydroxyproline and proline catabol... |
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Invention
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Synthesis of 3-hydroxybutyryl 3-hydroxybutyrate and related compounds.
In various embodiments me... |
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Invention
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Kibra peptides and uses thereof. inter aliainter alia, are C-terminal KIBRA peptides that are use... |
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2023
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Invention
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Epigenetic clock. Provided herein are methods and compositions for an epigenetic clock comprising... |
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Invention
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Suppressors of site iq electron leak and uses thereof. Described herein, inter alia, are suppress... |
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Invention
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Smart cell drug delivery. In some embodiments, a smart cell drug delivery (SmaCD) system is provi... |
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Invention
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Treatment of a senescence-associated ocular disease or disorder using a bcl-xl selective inhibito... |
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Invention
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Novel ketone ester compounds.
Ester compounds are provided herein that when administered to a ma... |
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Invention
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Novel ketone ester compounds. e.g., inter aliainter alia, in the treatment and/or prophylaxis of ... |
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Invention
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Formulations for extending lifespan and healthspan.
Described herein are compositions for delayi... |
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2022
|
Invention
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25-hydroxycholesterol (25hc), cryab aggregation inhibitor to amelioriate vascular stiffness.
Met... |
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Invention
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25-hydroxycholesterol (25hc), cryab aggregation inhibitor to amelioriate vascular stiffness. ,e.g... |
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|
Invention
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Use of exogenous ketone esters to induce weight loss in mammals.
In various embodiments method a... |
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Invention
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Use of exogenous ketone esters to induce weight loss in mammals. In various embodiments method an... |
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2021
|
Invention
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Synergistic modulators of alpha-dicarbonyl detoxification and their use for inducing weight loss ... |
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Invention
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N-propargylglycine: a unique inhibitor of proline dehydrogenase with brain-enhancing mitohormesis... |
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Invention
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Heteroaryl amide inhibitors of cd38. Disclosed are heteroaryl amide inhibitors of CD38 and method... |
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|
Invention
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Dihomo-gamma linolenic acid (dgla) is a novel senolytic.
Methods are provided that relate to the... |
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Invention
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Dihomo-gamma linolenic acid (dgla) is a novel senolytic. Methods are provided that relate to the ... |
|
|
Invention
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Treatment of viral pathologies with exogenous ketones.
Provided herein are methods for the treat... |
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Invention
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Treatment of viral pathologies with exogenous ketones. Provided herein are methods for the treatm... |
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2020
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Invention
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Treating cardiovascular disease by selectively eliminating senescent cells. Methods are provided ... |
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Invention
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Treating liver disease by selectively eliminating senescent cells. Methods are provided herein fo... |
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Invention
|
Treating cognitive decline and other neurodegenerative conditions by selectively removing senesce... |
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|
Invention
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Use of a heterocyclic bcl-2 inhibitor for removing senescent cells and treating senescence-associ... |
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|
Invention
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Methods and compositions for altering senescence associated secretory phenotype.
Disclosed herei... |
|
|
Invention
|
Methods and compositions for altering senescence associated secretory phenotype. Disclosed herein... |
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|
Invention
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Use of a heterocyclic bcl-xl inhibitor and related analogs for removing senescent cells in the tr... |
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Invention
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P16ink4a inhibitor for preventing or treating huntington's disease.
A p16INK4a inhibitor, a comp... |
|
|
Invention
|
25-hydroxycholesterol (25hc), cryab aggregation inhibitor, is a novel senolytic.
Methods and com... |
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|
Invention
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25-hydroxycholesterol (25hc), cryab aggregation inhibitor, is a novel senolytic. Methods and comp... |
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|
Invention
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Ink4a inhibitor for preventing or treating huntington's disease. The present invention relates pl... |
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Invention
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Substituted [1,2,3]triazolo[4,5-d]pyrimidines that lower stress-induced p-tau. In certain embodim... |
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|
Invention
|
Methods of inducing autophagy using coumarin derivatives and related compounds.
In various embod... |
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Invention
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Methods of inducing autophagy using coumarin derivatives and related compounds. e.g inter alia in... |
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2019
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Invention
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S3qels to protect against intestinal permeability.
In various embodiments methods for the treatm... |
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Invention
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Nicotinamide riboside compositions for healthspan extension.
Described herein are methods and co... |
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|
Invention
|
Gene-drive in dna viruses. In various embodiments methods of utilizing gene drive constructs in a... |
|
|
Invention
|
Synthesis of 3-hydroxybutyryl 3-hydroxybutyrate and related compounds. In various embodiments met... |
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2018
|
Invention
|
Biomarker for senescent cells.
Various biological markers that function as indicators of the lev... |
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Invention
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Treatment of lung diseases using pharmaceutical agents that eliminate senescent cells.
This inve... |
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Invention
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Biomarkers for detecting senescent cells. The present invention provides a method of detecting se... |
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2014
|
Invention
|
App specific bace inhibitors (asbis) and uses thereof. In certain embodiments APP-specific BACE i... |
