Produits et services

Antiseptics; chemico-pharmaceutical preparations; anaesthetics; pharmaceutical preparations; vaccines; anti-inflammatory preparations; pharmaceuticals for the treatment of infectious diseases; pharmaceutical preparations to be inhaled for the prevention and treatment of respiratory diseases and disorders; pharmaceuticals for the treatment of cancer; balsamic preparations for medical purposes; drugs for medical purposes; biological preparations for medical purposes; medicines for human purposes; diagnostic reagents for medical purposes; pharmaceuticals for the treatment of viral diseases; diagnostic preparations for medical purposes. Testing apparatus for medical purposes; medical apparatus and instruments. Retail or wholesale services for medical supplies; retail or wholesale services for medicines; retail or wholesale services for pharmaceutical preparations; marketing; sales promotion for others. Drug development; pharmaceutical research; clinical trials.

Abrégé

The present application relates to a compound as represented by formula I, an isomer, an isotope marker or a pharmaceutically acceptable salt thereof, and the uses thereof as an ATR kinase inhibitor and for treating cancers, wherein each group is as defined herein.

Classes IPC  ?

• C07D 487/06 - Systèmes condensés en péri
• C07D 498/04 - Systèmes condensés en ortho
• C07D 471/16 - Systèmes condensés en péri
• A61K 31/55 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à sept chaînons, p. ex. azélastine, pentylènetétrazole
• A61P 35/00 - Agents anticancéreux

Abrégé

The present invention relates to a compound as represented by formula I, a pharmaceutically acceptable salt, an isomer, or an isotope marker thereof. The compound can be used as an LSD1 inhibitor, and can also be used for preventing or treating tumors such as hematological neoplasms and small cell lung cancer.

Classes IPC  ?

• C07D 401/04 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
• C07D 471/04 - Systèmes condensés en ortho
• C07D 519/00 - Composés hétérocycliques contenant plusieurs systèmes de plusieurs hétérocycles déterminants condensés entre eux ou condensés avec un système carbocyclique commun non prévus dans les groupes ou
• C07D 487/04 - Systèmes condensés en ortho
• A61P 35/00 - Agents anticancéreux
• A61K 31/437 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à cinq chaînons ayant l'azote comme hétéro-atome du cycle, p. ex. indolizine, bêta-carboline

Produits et services

Retail or wholesale services for medical supplies; retail or wholesale services for medicines; retail or wholesale services for pharmaceutical preparations; marketing; sales promotion for others. Antiseptics; chemico-pharmaceutical preparations; anaesthetics; pharmaceutical preparations; vaccines; anti-inflammatory preparations; pharmaceuticals for the treatment of infectious diseases; pharmaceutical preparations to be inhaled for the prevention and treatment of respiratory diseases and disorders; pharmaceuticals for the treatment of cancer; balsamic preparations for medical purposes; drugs for medical purposes; biological preparations for medical purposes; medicines for human purposes; diagnostic reagents for medical purposes; pharmaceuticals for the treatment of viral diseases; diagnostic preparations for medical purposes. Testing apparatus for medical purposes; medical apparatus and instruments. Drug development; pharmaceutical research; clinical trials.

Produits et services

Medical genetic characteristics test reagents; antiseptics; bath preparations for medical purposes; chemico-pharmaceutical preparations; anaesthetics; pharmaceutical preparations; vaccines; medicine cases, portable, filled; lotions for pharmaceutical purposes; liniments; nutritive substances for microorganisms; sedatives; styptic preparations; chemical preparations for pharmaceutical purposes; medicinal drinks; medicated soap; medicines in form of tablet form; medicinal oil solutions; prepared Chinese medicines; tonics [medicines]; immunostimulants; liquid medicines; adhesive patches for medical purposes; blood products; anti-inflammatory preparations; pharmaceuticals for the treatment of infectious diseases; pharmaceutical preparations to be inhaled for the prevention and treatment of respiratory diseases and disorders; slimming pills; injectable medicinal solutions; medicinal ointments; biochemical medicines; pharmaceuticals for the treatment of cancer; pharmaceutical preparations for the treatment of hypercholesteremia; nutraceutical preparations for therapeutic or medical purposes; tinctures for medical purposes; active pharmaceutical ingredient; bacteriological preparations for medical purposes; pharmaceutical preparations for the treatment of hyperlipidemia; oral care preparations, medicated; reagents for use in medical genetic testing; medicinal alcohol; balsamic preparations for medical purposes; capsules for medicines; vitamin preparations; disinfectants; drugs for medical purposes; medicinal tea; suppositories; biological preparations for medical purposes; medicines for human purposes; chemical reagents for medical or veterinary purposes; diagnostic reagents for medical purposes; pharmaceuticals for the treatment of viral diseases; medical immunoassay reagents; chemical preparations for the diagnosis of pregnancy; pharmaceutical preparations for skin care; diagnostic preparations for medical purposes; antibiotics; dietetic foods adapted for medical purposes; nutritional supplements; food for babies; dietetic beverages adapted for medical purposes; infant formula; depuratives; medicines for veterinary purposes; pesticides; biocides; bandages for dressings; babies' diapers; dressings, medical; wadding for medical purposes; pants, absorbent, for incontinence; medicinal health kit; eyepatches for medical purposes; adhesive tapes for medical purposes; tissues impregnated with pharmaceutical lotions; disinfectant wipes; surgical glues; dental abrasives; teeth filling material; dental mastics; alloys of precious metals for dental purposes; diapers for pets. Retail or wholesale services for medical supplies; retail or wholesale services for sanitary preparations; retail or wholesale services for medicines; retail or wholesale services for pharmaceutical preparations. Grinding; processing of medicinal materials; services of a dental technician; processing of chemical reagents. Drug development; pharmaceutical product evaluation; pharmaceutical research; conducting early evaluations in the field of new pharmaceuticals; scientific research and development; scientific investigations for medical purposes; technological research; pharmaceutical research; chemical research; cosmetic research; biochemical research and analysis; biological research; clinical trials; bacteriological research; biological cloning services; DNA screening for scientific research purposes; bacteriological research and analysis; material testing.

Produits et services

Sales promotion services for third parties; commercial administration of the licensing of the goods and services of others; presentation of goods on communication media, for retail purposes. Medicinal materials processing; processing of chemical reagents.

Produits et services

Sales promotion services for third parties; business assistance, advisory and consulting services in the field of commercial administration of the licensing of the goods and services of others; presentation of goods on all forms of media communications stations, systems, networks, and services for the purpose of promoting the goods and services of others Medicinal materials processing, comprising slicing, steaming and soaking of medicinal materials; processing of chemical reagents used for preparation, production and application guidance of polymerace chain reaction (PCR) agents for testing of samples such as serum, sputum and secretions as well as for preparation, production and application guidance of biochemical agents used in testing of samples such as blood and body fluids

Abrégé

A pharmaceutical composition for treating gout and its application in preparation of medicines for treating gout are provided. The said pharmaceutical composition comprises effective amount of febuxostat or its pharmaceutical salts or its solvates and a uric acid eliminant.

Classes IPC  ?

• A61K 31/425 - Thiazoles
• A61K 9/20 - Pilules, pastilles ou comprimés
• A61K 9/48 - Préparations en capsules, p. ex. de gélatine, de chocolat
• A61K 9/16 - AgglomérésGranulésMicrobilles
• A61K 9/08 - Solutions
• A61P 19/06 - Agents antigoutte, p. ex. agents antihyperuricémiants ou uricosuriques

Produits et services

Medical paste; chemico-pharmaceutical preparations; medicines for human purposes; dressings (medical); tissue paper impregnated with disinfectants; teeth filling material; medicinal drinks; adhesive tapes for medical purposes; dietetic food preparations adapted for medical purposes; solutions for contact lenses. Dental apparatus; hearing aids for the deaf; contraceptives, non-chemical; surgical implants; orthopedic articles; suture materials; furniture especially made for medical purposes; medical apparatus and instruments. Processing of medicinal materials; processing and handling of chemical reagents.

Produits et services

(1) Surgical and topical anaesthetics; analgesics; antipyretics; non-steroidal anti-inflammatory medicines; medicines used to treat gout; medicines used to treat disease modifying agents in rheumatoid disorders;antiallergics; medicine used in anaphylaxis; antidotes to counteract poisons; anticonvulsants; anti-epileptics; anti-infectives; anti-migraine medicine; anti-neoplastic; immunosuppressives used in palliative care; pharmaceutical preparations for the treatment of the central nervous system, namely, encephalitis, epilepsy, Alzheimer's, cerebral palsy, Parkinson's disease; herbal supplements and pharmaceutical preparations for the treatment of cardiovascular diseases; pharmaceutical preparations for use in dermatology, namely, dermatitis, skin pigmentation diseases, sexually transmitted diseases; pharmaceutical preparations for the treatment of genitourinary diseases, namely, urological diseases, infertility, sexually transmitted diseases, inflammatory pelvic diseases; pharmaceutical preparations for the treatment of gastrointestinal diseases; hormones for humans, namely, human growth hormones, hormone replacement therapy preparations; contraceptives, namely, condoms, diaphragms, foams, oral, sponges, spermicides; opthalmological preparations; medicine acting on the respiratory tract; vitamins; minerals; PCR reagent used to test sputum; PCR reagent used in the hepatis; PCR reagent used in respiratory disease; PCR reagent used in venereal disease; PCR reagent used in bacterial disease; chemical preparations used to test blood; chemical preparations used to test sputum; pharmaceutical preparations for the treatment of blood disorders, the treatment of cancer, headaches, headaches, immunologic diseases, namely, autoimmune diseases, immunologic deficiency syndromes, infectious diseases, namely, respiratory infections, eye infections, inflammatory diseases, namely, inflammatory bowel diseases, inflammatory connective tissue diseases, psychiatric diseases, namely, mood disorders, anxiety disorders, cognitive disorders, the musculoskeletal system, namely, connective tissue disorders, bone diseases, spinal diseases, back pain, fractures, sprains, cartilage injuries, the respiratory system; pharmaceutical preparations for use in gastroenterology.